Page last updated: 2024-12-05

1-naphthalenesulfonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1-Naphthalenesulfonic acid: A Versatile Building Block

**What it is:** 1-Naphthalenesulfonic acid (1-NSA) is an organic compound with the formula C₁₀H₇SO₃H. It is a white to light brown solid that is readily soluble in water. The molecule consists of a naphthalene ring (two fused benzene rings) with a sulfonic acid group (-SO₃H) attached at the 1-position.

**Importance in research:**

1-NSA is a crucial **building block** for various applications in research and industry, primarily due to its:

* **Versatility:** It serves as a starting material for the synthesis of a wide range of chemical compounds, including dyes, pharmaceuticals, and polymers.
* **Reactivity:** The sulfonic acid group makes it amenable to various chemical reactions, including:
* **Nucleophilic substitution:** The sulfonic acid group can be easily replaced with other functional groups.
* **Electrophilic aromatic substitution:** The naphthalene ring can be further functionalized with various electrophiles.
* **Dyeing properties:** 1-NSA is used as an intermediate in the production of azo dyes, which are widely used in the textile and paper industries.
* **Pharmaceutical applications:** It is used in the synthesis of sulfonamide drugs, which are used to treat bacterial infections.
* **Surfactant properties:** 1-NSA can be used to produce surfactants, which are compounds that reduce surface tension between liquids.

**Specific research applications:**

* **Organic synthesis:** 1-NSA serves as a starting material for the synthesis of a wide variety of organic compounds, including novel drug candidates and materials.
* **Catalysis:** Its sulfonic acid group makes it a potential catalyst for various organic reactions.
* **Materials science:** 1-NSA can be used to develop new materials with specific properties, such as conductivity and optical activity.
* **Environmental chemistry:** Studies focus on its potential use in wastewater treatment and environmental remediation.

**Overall, 1-naphthalenesulfonic acid is a versatile and important compound in various research fields. Its unique chemical properties make it a valuable tool for developing new technologies and solving important scientific challenges.**

Cross-References

ID SourceID
PubMed CID6812
CHEMBL ID1160029
CHEBI ID30895
SCHEMBL ID4323
MeSH IDM0398958

Synonyms (44)

Synonym
AC-18225
AKOS009031607
EN300-19780
.alpha.-naphthalenesulfonic acid
naphthalene-1-sulfonic acid
CHEBI:30895 ,
alpha-naphthalenesulfonic acid
1-naphthalenesulfonic acid
naphthalene-1-sulphonic acid
85-47-2
1-naphthalenesulfonic acid, >50%
68153-01-5
naphthalenesulphonic acid
naphthalenesulfonic acid
pszynbskgubxeh-uhfffaoysa-
inchi=1/c10h8o3s/c11-14(12,13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7h,(h,11,12,13)
naphthalene-1-sulfonic acid anion
CHEMBL1160029
A841338
1-naphthalenemonosulfonate
einecs 201-610-1
0sjh61wm2j ,
unii-0sjh61wm2j
25155-19-5
unii-vzw67vii75
vzw67vii75 ,
einecs 246-676-2
68412-23-7
FT-0631399
1-sulfonaphthalene
ht-907
1-naphthalenesulfonic acid [mi]
SCHEMBL4323
naphtalenesulfonic acid
naphthalene sulfonic acid
naphthalene-alpha-sulphonic acid
DTXSID7048033
1-naphthyl sulfonic acid
W-109309
mfcd00003987
CS-0238578
Q10395591
4-(5-carboxy-pyridin-2-yl)-piperazine-1-carboxylicacidtert-butylester
C13420
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
naphthalenesulfonic acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Choline O-acetyltransferaseHomo sapiens (human)Ki1,600.00000.10001.30003.0000AID52124
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
phosphatidylcholine biosynthetic processCholine O-acetyltransferaseHomo sapiens (human)
neurotransmitter transportCholine O-acetyltransferaseHomo sapiens (human)
neuromuscular synaptic transmissionCholine O-acetyltransferaseHomo sapiens (human)
acetylcholine biosynthetic processCholine O-acetyltransferaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
choline O-acetyltransferase activityCholine O-acetyltransferaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleusCholine O-acetyltransferaseHomo sapiens (human)
cytosolCholine O-acetyltransferaseHomo sapiens (human)
synapseCholine O-acetyltransferaseHomo sapiens (human)
cytoplasmCholine O-acetyltransferaseHomo sapiens (human)
neuron projectionCholine O-acetyltransferaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID52124Inhibition of choline acetyltransferase isolated from squid head ganglia1981Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
Interaction of aromatic dyes with the coenzyme A binding site of choline acetyltransferase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (40.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.47 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index54.06 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]