| Protein | Synonyms | Taxonomy |
|---|
| 2-deoxy-scyllo-inosose synthase | DOI synthase; DOIS; EC 4.2.3.124 | Streptomyces fradiae |
| Paromamine 6'-oxidase | EC 1.1.3.43; 6'''-hydroxyneomycin C oxidase; 1.1.3.44; Neomycin biosynthesis protein 11; Neo-11; Neomycin biosynthesis protein Q | Streptomyces fradiae |
| 2'-N-acetylparomamine deacetylase | EC 3.5.1.112; 2'''-acetyl-6'''-hydroxyneomycin C deacetylase; 3.5.1.113; Neomycin biosynthesis protein 16; Neo-16; Neomycin biosynthesis protein L | Streptomyces fradiae |
| L-glutamine:2-deoxy-scyllo-inosose aminotransferase | L-glutamine:DOI aminotransferase; EC 2.6.1.100; Bifunctional L-glutamine:ketocyclitol aminotransferase I/II; L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase; L-glutamine:amino-DOI aminotransferase; 2.6.1.101 | Streptomyces fradiae |
| Neamine transaminase NeoN | EC 2.6.1.93; Glutamate--6'-dehydroparomamine aminotransferase; Neomycin C transaminase; 2.6.1.95; Neomycin biosynthesis protein 18; Neo-18; Neomycin biosynthesis protein B; Neomycin biosynthesis protein N | Streptomyces fradiae |
| 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase | EC 2.4.1.283; Neomycin biosynthesis protein 8; Neo-8; Neomycin biosynthesis protein D | Streptomyces fradiae |
| 2-deoxy-scyllo-inosamine dehydrogenase | DOIA dehydrogenase; EC 1.1.1.329 | Streptomyces fradiae |
| Putative phosphatase in neomycin pathway, NeoP | | Streptomyces fradiae |
| UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase | EC 2.4.1.285; Neomycin biosynthesis protein 15; Neo-15; Neomycin biosynthesis protein K | Streptomyces fradiae |
| Putative neomycin production protein, NeoL | | Streptomyces fradiae |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| Cobalt | A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. |
| uridine diphosphate | A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. |
| NADH | |
| Copper | A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Orthophosphate | |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| 2-deoxy-scyllo-inosamine | RN given refers to (DL)-isomer; structure in first source. |
| 2'-N-acetylparomamine | structure in first source |
| paromamine | RN given refers to (D)-isomer |
| neamine | fragment of NEOMYCIN B; structure in first source |
| neomycin C | RN given refers to parent cpd |
| 2-deoxyinosose | structure given in first source; an early intermediate in the biosynthesis of 2-deoxystreptamine |
| alpha-Ketoglutarate | |
| 2-deoxystreptamine | RN given refers to parent cpd; structure. |
| glutamate | |
| Glucose-6-Phosphate | An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed) |
| polyglutamine | RN given for (D)-isomer |
| alpha-ketoglutaramate | deaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |