Page last updated: 2024-10-06

superpathway of neomycin biosynthesis

Proteins (10)

ProteinSynonymsTaxonomy
2-deoxy-scyllo-inosose synthaseDOI synthase; DOIS; EC 4.2.3.124Streptomyces fradiae
Paromamine 6'-oxidaseEC 1.1.3.43; 6'''-hydroxyneomycin C oxidase; 1.1.3.44; Neomycin biosynthesis protein 11; Neo-11; Neomycin biosynthesis protein QStreptomyces fradiae
2'-N-acetylparomamine deacetylaseEC 3.5.1.112; 2'''-acetyl-6'''-hydroxyneomycin C deacetylase; 3.5.1.113; Neomycin biosynthesis protein 16; Neo-16; Neomycin biosynthesis protein LStreptomyces fradiae
L-glutamine:2-deoxy-scyllo-inosose aminotransferaseL-glutamine:DOI aminotransferase; EC 2.6.1.100; Bifunctional L-glutamine:ketocyclitol aminotransferase I/II; L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase; L-glutamine:amino-DOI aminotransferase; 2.6.1.101Streptomyces fradiae
Neamine transaminase NeoNEC 2.6.1.93; Glutamate--6'-dehydroparomamine aminotransferase; Neomycin C transaminase; 2.6.1.95; Neomycin biosynthesis protein 18; Neo-18; Neomycin biosynthesis protein B; Neomycin biosynthesis protein NStreptomyces fradiae
2-deoxystreptamine N-acetyl-D-glucosaminyltransferaseEC 2.4.1.283; Neomycin biosynthesis protein 8; Neo-8; Neomycin biosynthesis protein DStreptomyces fradiae
2-deoxy-scyllo-inosamine dehydrogenaseDOIA dehydrogenase; EC 1.1.1.329Streptomyces fradiae
Putative phosphatase in neomycin pathway, NeoP Streptomyces fradiae
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferaseEC 2.4.1.285; Neomycin biosynthesis protein 15; Neo-15; Neomycin biosynthesis protein KStreptomyces fradiae
Putative neomycin production protein, NeoLStreptomyces fradiae

Compounds (25)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
NADH
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
2-deoxy-scyllo-inosamineRN given refers to (DL)-isomer; structure in first source.
2'-N-acetylparomaminestructure in first source
paromamineRN given refers to (D)-isomer
neaminefragment of NEOMYCIN B; structure in first source
neomycin CRN given refers to parent cpd
2-deoxyinososestructure given in first source; an early intermediate in the biosynthesis of 2-deoxystreptamine
alpha-Ketoglutarate
2-deoxystreptamineRN given refers to parent cpd; structure.
glutamate
Glucose-6-PhosphateAn ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
polyglutamineRN given for (D)-isomer
alpha-ketoglutaramatedeaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)