Page last updated: 2024-10-06

kanamycin biosynthesis

Proteins (10)

ProteinSynonymsTaxonomy
2-deoxy-scyllo-inosose synthaseDOI synthase; DOIS; EC 4.2.3.124Streptomyces kanamyceticus
L-glutamine:2-deoxy-scyllo-inosose aminotransferaseL-glutamine:DOI aminotransferase; EC 2.6.1.100; L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase; L-glutamine:amino-DOI aminotransferase; 2.6.1.101Streptomyces kanamyceticus
2'-dehydrokanamycin reductaseEC 1.1.1.355; Kanamycin biosynthesis protein KStreptomyces kanamyceticus
2-deoxystreptamine glucosyltransferaseEC 2.4.1.284; 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase; 2.4.1.283; Kanamycin biosynthesis protein FStreptomyces kanamyceticus
Alpha-D-kanosaminyltransferaseEC 2.4.1.301; 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase; Glycosyltransferase KanE; Kanamycin biosynthesis protein EStreptomyces kanamyceticus
Kanamycin B dioxygenaseEC 1.14.11.37; Kanamycin biosynthesis protein JStreptomyces kanamyceticus
2'-deamino-2'-hydroxyneamine transaminaseEC 2.6.1.94; Kanamycin biosynthesis protein B; Neamine transaminase KanB; 2.6.1.93Streptomyces kanamyceticus
2-deoxy-scyllo-inosamine dehydrogenaseDOIA dehydrogenase; EC 1.1.1.329Streptomyces kanamyceticus
KanIStreptomyces kanamyceticus
KanN Streptomyces kanamyceticus

Compounds (26)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Succinate
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
Ammonium
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
2-deoxy-scyllo-inosamineRN given refers to (DL)-isomer; structure in first source.
2'-N-acetylparomaminestructure in first source
paromamineRN given refers to (D)-isomer
neaminefragment of NEOMYCIN B; structure in first source
2-deoxyinososestructure given in first source; an early intermediate in the biosynthesis of 2-deoxystreptamine
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
2-deoxystreptamineRN given refers to parent cpd; structure.
glutamate
Glucose-6-PhosphateAn ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
polyglutamineRN given for (D)-isomer
alpha-ketoglutaramatedeaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure
Kanamycin A