Leucine Biosynthesis

Proteins (8)

Protein	Synonyms	Taxonomy
2-isopropylmalate synthase	EC 2.3.3.13; Alpha-IPM synthase; Alpha-isopropylmalate synthase	Escherichia coli K-12
3-isopropylmalate dehydratase large subunit	EC 4.2.1.33; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase	Escherichia coli K-12
3-isopropylmalate dehydratase small subunit	EC 4.2.1.33; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase	Escherichia coli K-12
Branched-chain-amino-acid aminotransferase	BCAT; EC 2.6.1.42; Transaminase B	Escherichia coli K-12
3-isopropylmalate dehydrogenase	EC 1.1.1.85; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH	Escherichia coli K-12
Aromatic-amino-acid aminotransferase	ARAT; AROAT; EC 2.6.1.57; Beta-methylphenylalanine transaminase; 2.6.1.107	Escherichia coli K-12
Lysine exporter LysO	Lys outward permease	Escherichia coli K-12
D-malate dehydrogenase [decarboxylating]	EC 1.1.1.83; D-malate degradation protein A; D-malate oxidase	Escherichia coli K-12

Compound	Description
hydronium ion
Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acid	A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Coenzyme A
2-oxo-3-methylvalerate
alpha-ketoglutaric acid
alpha-isopropylmalate	structure
beta-isopropylmalate	RN given refers to (threo-(D)-isomer)
NAD	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
leucine	An essential branched-chain amino acid important for hemoglobin formation.
2-keto-4-methylvalerate
acetyl coenzyme a	Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.