Page last updated: 2024-10-06

L-proline biosynthesis I

Proteins (5)

ProteinSynonymsTaxonomy
Glutamate 5-kinaseEC 2.7.2.11; Gamma-glutamyl kinase; GKEscherichia coli K-12
Delta-1-pyrroline-5-carboxylate synthaseP5CS; Aldehyde dehydrogenase family 18 member A1Homo sapiens (human)
Pyrroline-5-carboxylate reductase 1, mitochondrialP5C reductase 1; P5CR 1; EC 1.5.1.2Homo sapiens (human)
Gamma-glutamyl phosphate reductaseGPR; EC 1.2.1.41; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenaseEscherichia coli K-12
Pyrroline-5-carboxylate reductaseP5C reductase; P5CR; EC 1.5.1.2; PCA reductaseEscherichia coli K-12

Compounds (12)

CompoundDescription
hydronium ion
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
delta-1-pyrroline-5-carboxylate(L)-isomer is the biologically active form; RN given refers to cpd without isomeric designation; structure
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.