Page last updated: 2024-10-21

urea and Sepsis

urea has been researched along with Sepsis in 78 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia."9.34Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial. ( Kakihana, Y; Matsuda, N; Morimatsu, H; Morishima, E; Nagano, T; Nishida, O; Ogura, H; Okajima, M; Taniguchi, T; Yamada, Y, 2020)
"Our aim was to compare the effects of intravenous, enteral, and enteral plus intravenous supplemented glutamine on plasma transferrin, nitrogen balance, and creatinine/height index in septic patients with malnutrition."9.19The effects of intravenous, enteral and combined administration of glutamine on malnutrition in sepsis: a randomized clinical trial. ( Erbabacan, E; Karaoren, G; Koksal, GM; Oz, H; Tunali, Y; Vehid, S, 2014)
"To evaluate the effect of enteral nutrition (EN) supplemented with l-glutamine on glycolytic parameters, inflammation, immune function, and oxidative stress in moderately ill intensive care patients with sepsis."9.16Enteral nutrition supplemented with L-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection. ( Campelo, MW; Cavalcante, AA; de Vasconcelos, MP; de Vasconcelos, PR; Ferreira, CM; Garcia, JH; Guimarães, SB, 2012)
"We aimed to evaluate whether the administration of riboflavin to septic animals reduces inflammation, oxidative stress, organ dysfunction, and mortality."8.12Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis. ( Alves-Filho, JC; Aragon, DC; Carlotti, APCP; Cunha, FQ; Ferreira, RG; Nascimento, DC; Pineros, AR; Ramalho, FS; Santos, JD; Vale, AHF, 2022)
"This study was performed to investigate the interrelationship between gluconeogenesis and ureagenesis during sepsis."7.68Interrelationship between hepatic ureagenesis and gluconeogenesis in early sepsis. ( Clemens, MG; Ohtake, Y, 1991)
"The kinetic interactions among glucose, alanine, and urea metabolism were studied in both normal volunteers and in patients with sepsis by means of a primed, constant infusion of stable isotopes."7.67Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers. ( Klein, S; Shaw, JH; Wolfe, RR, 1985)
"We report a case of junctional ectopic tachycardia, preceded by sepsis, in a 4-year-old girl, 31 months after open-heart surgery."5.43Efficacy of landiolol for the treatment of junctional ectopic tachycardia resulting from sepsis. ( Azuma, H; Oka, H; Sugimoto, M, 2016)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."5.37Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"Landiolol resulted in significantly more patients with sepsis-related tachyarrhythmia achieving a heart rate of 60-94 bpm at 24 h and significantly reduced the incidence of new-onset arrhythmia."5.34Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial. ( Kakihana, Y; Matsuda, N; Morimatsu, H; Morishima, E; Nagano, T; Nishida, O; Ogura, H; Okajima, M; Taniguchi, T; Yamada, Y, 2020)
"Our aim was to compare the effects of intravenous, enteral, and enteral plus intravenous supplemented glutamine on plasma transferrin, nitrogen balance, and creatinine/height index in septic patients with malnutrition."5.19The effects of intravenous, enteral and combined administration of glutamine on malnutrition in sepsis: a randomized clinical trial. ( Erbabacan, E; Karaoren, G; Koksal, GM; Oz, H; Tunali, Y; Vehid, S, 2014)
"To evaluate the effect of enteral nutrition (EN) supplemented with l-glutamine on glycolytic parameters, inflammation, immune function, and oxidative stress in moderately ill intensive care patients with sepsis."5.16Enteral nutrition supplemented with L-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection. ( Campelo, MW; Cavalcante, AA; de Vasconcelos, MP; de Vasconcelos, PR; Ferreira, CM; Garcia, JH; Guimarães, SB, 2012)
"The administration of branched-chain amino acids (BCAAs) has been proved useful in reducing both urea nitrogen production and muscle proteolysis in trauma patients with sepsis, but the optimum infusion rate to achieve these effects is still in question."5.07Leucine dose response in the reduction of urea production from septic proteolysis and in the stimulation of acute-phase proteins. ( Bruzzone, P; Chiarla, C; Goodarzi, S; Placko, R; Siegel, JH; Wiles, CE, 1991)
"We aimed to evaluate whether the administration of riboflavin to septic animals reduces inflammation, oxidative stress, organ dysfunction, and mortality."4.12Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis. ( Alves-Filho, JC; Aragon, DC; Carlotti, APCP; Cunha, FQ; Ferreira, RG; Nascimento, DC; Pineros, AR; Ramalho, FS; Santos, JD; Vale, AHF, 2022)
"The underlying pathophysiology of liver dysfunction in urea cycle disorders (UCDs) is still largely elusive."3.85Metabolically based liver damage pathophysiology in patients with urea cycle disorders - A new hypothesis. ( Garavelli, L; Ivanovski, A; Ivanovski, I; Ivanovski, P; Ješić, M, 2017)
"To validate the Mortality in Emergency Department Sepsis (MEDS) score, the Confusion, Urea nitrogen, Respiratory rate, Blood pressure, 65 years of age and older (CURB-65) score, and a modified Rapid Emergency Medicine Score (mREMS) in patients with suspected infection."3.74Performance of severity of illness scoring systems in emergency department patients with infection. ( Clardy, P; Donnino, MW; Howell, MD; Ngo, L; Shapiro, NI; Talmor, D, 2007)
"This study was performed to investigate the interrelationship between gluconeogenesis and ureagenesis during sepsis."3.68Interrelationship between hepatic ureagenesis and gluconeogenesis in early sepsis. ( Clemens, MG; Ohtake, Y, 1991)
" The following factors correlated with the severity of brain dysfunction: adult respiratory distress syndrome; fatal outcome; certain types of EEG abnormality; axonal peripheral neuropathy; elevated peripheral white blood cell count; elevated serum levels of alkaline phosphatase, bilirubin, creatinine, phosphate, potassium, and urea; reduced blood pressure and reduced serum albumin level."3.68The encephalopathy associated with septic illness. ( Archibald, YM; Austin, TW; Bolton, CF; Gonder, J; Wells, GA; Young, GB, 1990)
"The kinetic interactions among glucose, alanine, and urea metabolism were studied in both normal volunteers and in patients with sepsis by means of a primed, constant infusion of stable isotopes."3.67Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers. ( Klein, S; Shaw, JH; Wolfe, RR, 1985)
"Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury."1.51Urotensin receptors as a new target for CLP induced septic lung injury in mice. ( Akpinar, E; Cadirci, E; Cinar, I; Dincer, B; Gundogdu, B; Halici, Z; Ugan, RA, 2019)
"We report a case of junctional ectopic tachycardia, preceded by sepsis, in a 4-year-old girl, 31 months after open-heart surgery."1.43Efficacy of landiolol for the treatment of junctional ectopic tachycardia resulting from sepsis. ( Azuma, H; Oka, H; Sugimoto, M, 2016)
"Sepsis is the most common trigger for acute kidney injury (AKI) in critically ill patients."1.38A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. ( Bagshaw, SM; Bellomo, R; Bennett, M; Devarajan, P; Haase, M; Haase-Fielitz, A, 2012)
"FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0."1.37Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study. ( Bernardin, G; Brochard, L; Cohen, Y; Darmon, M; Das, V; Dellamonica, J; Gonzalez, F; Schlemmer, B; Schortgen, F; Vincent, F; Zeni, F, 2011)
"We examined the influence of graft infection on serum creatinine levels in kidney recipients."1.37Graft infection in kidney recipients and its relation to transplanted kidney function. ( Biernawska, J; Bohatyrewicz, R; Brykczyński, M; Ciechanowicz, A; Kaczmarczyk, M; Kotfis, K; Nikodemski, T; Różański, J; Zegan-Barańska, M; Ziętek, Z; Zukowski, M, 2011)
"Hyperammonemia is encountered frequently in acutely ill children presenting for emergency care with altered levels of consciousness (ALOC)."1.36Hyperammonemia in the pediatric emergency care setting. ( Dabnon, M; Fouad, HM; Galal, NM; Saied, A, 2010)
" The pharmacokinetic profile of cefuroxime exhibited both one and two compartmental distribution."1.35Effect of severity disease on the pharmacokinetics of cefuroxime in children with multiple organ system failure. ( Asseff, IL; Guillé, GP; Olguín, HJ; Pérez, AG; Quesada, AC; Saldaña, NG; Vieyra, AC, 2008)
"Early AA administration was not associated with any clinically significant adverse effects; it was associated with reduction in the incidence of sepsis and marginally effective in reducing time to regain birth weight."1.33Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison. ( Benadiba-Torch, A; Cuddy, A; Kotsopoulos, K; Shah, PS, 2006)
"Urea production was increased by alanine to a greater extent in the septic group compared to sham."1.29Hormone effects on hepatic substrate preference in sepsis. ( Clemens, MG; Paidas, CN, 1994)
"Urea- clones were also found in three of six other strains of P."1.26Unusual Enterobacteriaceae. "Proteus rettgeri" that "change" into Providencia stuartii. ( Brenner, DJ; Farmer, JJ; Hickman, FW; Rickenbach, DG; Schreiber, M, 1977)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199029 (37.18)18.7374
1990's9 (11.54)18.2507
2000's9 (11.54)29.6817
2010's22 (28.21)24.3611
2020's9 (11.54)2.80

Authors

AuthorsStudies
Ferrario, M1
Pastorelli, R1
Brunelli, L1
Liu, S1
Zanella do Amaral Campos, PP1
Casoni, D1
Z'Graggen, WJ1
Jakob, SM1
Vale, AHF1
Nascimento, DC1
Pineros, AR1
Ferreira, RG1
Santos, JD1
Aragon, DC1
Cunha, FQ1
Ramalho, FS1
Alves-Filho, JC1
Carlotti, APCP1
Alves, GF1
Stoppa, I1
Aimaretti, E1
Monge, C1
Mastrocola, R1
Porchietto, E1
Einaudi, G1
Collotta, D1
Bertocchi, I1
Boggio, E1
Gigliotti, CL1
Clemente, N1
Aragno, M1
Fernandes, D1
Cifani, C1
Thiemermann, C1
Dianzani, C1
Dianzani, U1
Collino, M1
Zhai, B1
Ma, LS1
Shen, RQ1
Yu, J1
Tao, YN1
Xu, AP1
Shao, DC1
Ibrahim, YF1
Fadl, RR1
Ibrahim, S1
Gayyed, MF1
Bayoumi, A1
Refaie, M1
Kakihana, Y1
Nishida, O1
Taniguchi, T1
Okajima, M1
Morimatsu, H1
Ogura, H1
Yamada, Y1
Nagano, T1
Morishima, E1
Matsuda, N1
Morelli, A1
Whitehouse, T1
Rehberg, S1
Sivak, KV1
Stosman, KI1
Rassokha, TA1
Aleksandrov, AG1
Kuzmich, NN1
Orshanskaya, YR1
Savateeva-Lubimova, TN1
Lesiovskaya, EE1
Du, F1
Sun, W1
Morisseau, C1
Hammock, BD1
Bao, X1
Liu, Q1
Wang, C1
Zhang, T1
Yang, H1
Zhou, J1
Xiao, W1
Liu, Z1
Chen, G1
Parkhomenko, E1
De Fazio, A1
Tran, T1
Thai, J1
Blum, K1
Gupta, M1
Ivanovski, I1
Ješić, M1
Ivanovski, A1
Garavelli, L1
Ivanovski, P1
Mathieu, C1
Desrois, M1
Kober, F1
Lalevée, N1
Lan, C1
Fourny, N1
Iché-Torres, M1
Tran, TT1
Lê, LT1
Singer, M1
Mège, JL1
Bernard, M1
Leone, M1
Cadirci, E1
Ugan, RA1
Dincer, B1
Gundogdu, B1
Cinar, I1
Akpinar, E1
Halici, Z1
Schiffl, H1
Fischer, R1
Lang, SM1
Koksal, GM1
Erbabacan, E1
Tunali, Y1
Karaoren, G1
Vehid, S1
Oz, H1
Seki, Y1
Jesmin, S2
Shimojo, N2
Islam, MM1
Rahman, MA1
Khatun, T2
Sakuramoto, H1
Oki, M1
Sonobe, A1
Kamiyama, J1
Hagiya, K1
Kawano, S2
Mizutani, T2
Oka, H1
Sugimoto, M1
Azuma, H1
Gasanov, MD1
Schick, MA1
Baar, W1
Bruno, RR1
Wollborn, J1
Held, C1
Schneider, R1
Flemming, S1
Schlegel, N1
Roewer, N1
Neuhaus, W1
Wunder, C1
Bojic, S1
Kotur-Stevuljevic, J1
Kalezic, N1
Stevanovic, P1
Jelic-Ivanovic, Z1
Bilanovic, D1
Memon, L1
Damnjanovic, M1
Kalaba, Z1
Simic-Ogrizovic, S1
Matsuishi, Y1
Hideaki, S1
Mowa, CN1
Akhtar, S1
Zaedi, S1
Tsunoda, Y1
Kiwamoto, T1
Hizawa, N1
Inoue, Y1
Andrades, M1
Ritter, C1
de Oliveira, MR1
Streck, EL1
Fonseca Moreira, JC1
Dal-Pizzol, F1
Avila, TV1
Bastos Pereira, AL1
De Oliveira Christoff, A1
Da Silva Soley, B1
Queiroz Telles, JE1
Eler, GJ1
Bracht, A1
Roberto Zampronio, A1
Acco, A1
Legido-Quigley, C1
Cloarec, O1
Parker, DA1
Murphy, GM1
Holmes, E1
Lindon, JC1
Nicholson, JK1
Mitry, RR1
Vilca-Melendez, H1
Rela, M1
Dhawan, A1
Heaton, N1
Galal, NM1
Fouad, HM1
Saied, A1
Dabnon, M1
Bagshaw, SM2
Haase, M1
Haase-Fielitz, A1
Bennett, M2
Devarajan, P2
Bellomo, R2
Darmon, M1
Vincent, F1
Dellamonica, J1
Schortgen, F1
Gonzalez, F1
Das, V1
Zeni, F1
Brochard, L1
Bernardin, G1
Cohen, Y1
Schlemmer, B1
Zukowski, M1
Kotfis, K1
Biernawska, J1
Zegan-Barańska, M1
Kaczmarczyk, M1
Ciechanowicz, A1
Brykczyński, M1
Różański, J1
Ziętek, Z1
Nikodemski, T1
Bohatyrewicz, R1
Cavalcante, AA1
Campelo, MW1
de Vasconcelos, MP1
Ferreira, CM1
Guimarães, SB1
Garcia, JH1
de Vasconcelos, PR1
Saha, M1
Aich, T1
Das, C1
Mukhopadhyay, M1
Patar, K1
Stuart-Clark, H1
Vorajee, N1
Zuma, S1
Van Niekerk, L1
Burch, V1
Raubenheimer, P1
Peter, JG1
Hackbarth, CJ1
Chen, DZ1
Lewis, JG1
Clark, K1
Mangold, JB1
Cramer, JA1
Margolis, PS1
Wang, W1
Koehn, J1
Wu, C1
Lopez, S1
Withers, G1
Gu, H1
Dunn, E1
Kulathila, R1
Pan, SH1
Porter, WL1
Jacobs, J1
Trias, J1
Patel, DV1
Weidmann, B1
White, RJ1
Yuan, Z1
Ruiz-Perez, B1
Cisneros, RL1
Matsumoto, T1
Miller, RJ1
Vasios, G1
Calias, P1
Onderdonk, AB1
BALS, M1
SERBANESCU, F1
CARUNTU, F1
TAINDEL, C1
JIPA, R1
PREDOVICIU, FM1
HULME, B1
KNIGHT, PR1
ELKINGTON, JS1
BLAINEY, JD1
DAWSON-EDWARDS, P1
Yoshida, Y1
Hongo, T1
Sakamoto, A1
Ogawa, R1
Struck, J1
Uhlein, M1
Morgenthaler, NG1
Fürst, W1
Höflich, C1
Bahrami, S1
Bergmann, A1
Volk, HD1
Redl, H1
Tang, J1
Cheung, PS1
Kotsopoulos, K1
Benadiba-Torch, A1
Cuddy, A1
Shah, PS1
Howell, MD1
Donnino, MW1
Talmor, D1
Clardy, P1
Ngo, L1
Shapiro, NI1
Olguín, HJ1
Asseff, IL1
Vieyra, AC1
Pérez, AG1
Saldaña, NG1
Quesada, AC1
Guillé, GP1
Gibson, DG1
Mickell, JJ1
Paidas, CN1
Clemens, MG2
Dahn, MS3
Lange, MP3
Berberoglu, ED1
Andrejko, KM1
Deutschman, CS1
Mayser, P1
Imkampe, A1
Winkeler, M1
Papavassilis, C1
Amyot, SL1
Leblanc, M1
Thibeault, Y1
Geadah, D1
Cardinal, J1
Shanson, DC1
Kensit, J1
Hince, C1
Farmer, JJ1
Hickman, FW1
Brenner, DJ1
Schreiber, M1
Rickenbach, DG1
McDougal, WS1
Wilmore, DW1
Pruitt, BA1
Bruzzone, P1
Siegel, JH1
Chiarla, C1
Wiles, CE1
Placko, R1
Goodarzi, S1
Ohtake, Y1
Young, GB1
Bolton, CF1
Austin, TW1
Archibald, YM1
Gonder, J1
Wells, GA1
Lehmkuhl, P1
Schultz, A1
Gebert, J1
Roth, E1
Jacobs, LA1
Hernández, G1
Celis, R1
Bavestrello, L1
Nercelles, P1
Barros, M1
González, R1
Toro, J1
Nelson, J1
Ormrod, DJ1
Miller, TE1
Shaw, JH1
Klein, S1
Wolfe, RR1
Cerra, FB1
Shronts, EP1
Konstantinides, NN1
Thoele, S1
Konstantinides, FN1
Teasley, K1
Lysne, J1
Fauser, U1
Douglas, RM1
Devitt, L1
Macartney, B1
Asbach, HW1
Stoeckel, H1
Schüler, HW1
Conradi, R1
Wiedemann, K1
Möhring, K1
Röhl, L1
Bottomley, JP1
Bradley, J1
Whitehouse, GH1
Vachon, F1
Carbon, C1
Josse, RG1
Malchow, H1
Seybold, D1
Lange, H1
Freund, J1
Rüger, K1
Preston, FE1
Malia, RG1
Sworn, MJ1
Blackburn, EK1
Ku, G1
Varghese, Z1
Fernando, ON1
Baillod, R1
Hopewell, JP1
Moorhead, JF1
Kinney, JM1
Gump, FE1
Long, CL1
Better, OS1
Garty, J1
Barzilai, A1
Erlik, D1
Abbott, GD1
Freake, R1
Marshall, VC1
Sforza, F1
Ciccu, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Controlled Trial of an Integrated Post-discharge Transitional Care Package for General Medical In-patients in Cape Town, South Africa[NCT01916876]0 participants (Actual)Interventional2015-03-31Withdrawn (stopped due to Funding shortage)
"Validation Study of the 4-question RACYDelirium Screening Tool in General Medical In-patients From a Developing Country Setting"[NCT01916889]1,093 participants (Actual)Interventional2013-09-30Completed
Effects of High vs. Standard Protein Intake in the Weight Gain and Renal Function Security in Newborn Extreme Premature[NCT02478086]Phase 252 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for urea and Sepsis

ArticleYear
Energy and tissue fuel in human injury and sepsis.
    Advances in experimental medicine and biology, 1972, Volume: 33, Issue:0

    Topics: Body Weight; Energy Metabolism; Female; Gluconeogenesis; Glucose; Humans; Liver; Male; Nitrogen; Oxi

1972

Trials

6 trials available for urea and Sepsis

ArticleYear
Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial.
    The Lancet. Respiratory medicine, 2020, Volume: 8, Issue:9

    Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Female; Humans; Male; Morpholines; Sepsis; Tachycardia

2020
The effects of intravenous, enteral and combined administration of glutamine on malnutrition in sepsis: a randomized clinical trial.
    Asia Pacific journal of clinical nutrition, 2014, Volume: 23, Issue:1

    Topics: Adult; Aged; Creatinine; Dietary Proteins; Dietary Supplements; Energy Intake; Enteral Nutrition; Fe

2014
Enteral nutrition supplemented with L-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection.
    Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Caseins; Dietary Supplements; Double-Blind Method; Enteral Nutrition

2012
Leucine dose response in the reduction of urea production from septic proteolysis and in the stimulation of acute-phase proteins.
    Surgery, 1991, Volume: 109, Issue:6

    Topics: Acute-Phase Proteins; Adult; Amino Acids, Branched-Chain; Energy Intake; Female; Humans; Leucine; Ma

1991
Insulinlike growth factor 1 production is inhibited in human sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1988, Volume: 123, Issue:11

    Topics: Adult; Amino Acids; Blood Glucose; Glucose; Growth Hormone; Humans; Insulin-Like Growth Factor I; Mi

1988
Enteral feeding in sepsis: a prospective, randomized, double-blind trial.
    Surgery, 1985, Volume: 98, Issue:4

    Topics: Adolescent; Adult; Aged; Amino Acids, Branched-Chain; Clinical Trials as Topic; Double-Blind Method;

1985

Other Studies

71 other studies available for urea and Sepsis

ArticleYear
Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.
    Scientific reports, 2021, 09-16, Volume: 11, Issue:1

    Topics: Ammonia; Animals; Cytokines; Female; Glucose; Lipid Metabolism; Male; Metabolome; Sepsis; Swine; Ure

2021
Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2022, Volume: 55

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antioxidants; Bayes Theorem; Chemokines; C

2022
ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Creatinine; Cytokines; Immune Checkpoint Proteins; Immunity; Immunomodulation; Inducible T-

2022
[Caspase-1/-11 participates in LPS-induced sepsis-associated acute kidney injury by cleaving GSDMD].
    Sheng li xue bao : [Acta physiologica Sinica], 2023, Feb-25, Volume: 75, Issue:1

    Topics: Acute Kidney Injury; Animals; Caspase 1; Caspases; Creatinine; Gasdermins; Lipopolysaccharides; Mice

2023
Protective effect of febuxostat in sepsis-induced liver and kidney injuries after cecal ligation and puncture with the impact of xanthine oxidase, interleukin 1
    Human & experimental toxicology, 2020, Volume: 39, Issue:7

    Topics: Acute Kidney Injury; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cecum; Creatinine;

2020
β-blockade in sepsis: regulation of persisting sepsis-related tachycardia.
    The Lancet. Respiratory medicine, 2020, Volume: 8, Issue:9

    Topics: Humans; Morpholines; Sepsis; Tachycardia; Urea

2020
The Effect of TLR4 Blockade on Some Indicators of Systemic Inflammatory Response to Proteus mirabilis LPS in Rats.
    Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:6

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Animals, Outbred Strains; Anti-Inflammatory Age

2020
Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis.
    European journal of medicinal chemistry, 2021, Nov-05, Volume: 223

    Topics: Animals; Binding Sites; Catalytic Domain; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Ep

2021
A Multi-Institutional Study of Struvite Stones: Patterns of Infection and Colonization.
    Journal of endourology, 2017, Volume: 31, Issue:5

    Topics: Adult; Enterococcus; Escherichia coli; Escherichia coli Infections; Female; Humans; Kidney Calculi;

2017
Metabolically based liver damage pathophysiology in patients with urea cycle disorders - A new hypothesis.
    World journal of gastroenterology, 2017, Nov-28, Volume: 23, Issue:44

    Topics: Ammonia; Central Nervous System; Citrullinemia; Enterobacter; Fatal Outcome; Hepatocytes; Humans; Hy

2017
Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study.
    Critical care medicine, 2018, Volume: 46, Issue:7

    Topics: Adrenergic beta-Antagonists; Animals; Female; Heart; Magnetic Resonance Imaging; Male; Morpholines;

2018
Urotensin receptors as a new target for CLP induced septic lung injury in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:2

    Topics: Acute Lung Injury; Animals; Cecum; Cytokines; Gene Expression; Glutathione; Ligation; Lung; Male; Ma

2019
Assessment of dialysis dose in critically ill maintenance dialysis patients.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2014, Volume: 18, Issue:5

    Topics: Aged; Aged, 80 and over; APACHE; Critical Illness; Dialysis Solutions; Female; Hospital Mortality; H

2014
Significant reversal of cardiac upregulated endothelin-1 system in a rat model of sepsis by landiolol hydrochloride.
    Life sciences, 2014, Nov-24, Volume: 118, Issue:2

    Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Endothelin-1; Hemodynamics; Interleukin-6; Male

2014
Efficacy of landiolol for the treatment of junctional ectopic tachycardia resulting from sepsis.
    Cardiology in the young, 2016, Volume: 26, Issue:1

    Topics: Anti-Arrhythmia Agents; Child, Preschool; Female; Humans; Morpholines; Sepsis; Tachycardia, Ectopic

2016
[Рformation of algorithms to determine the severity of endotoxemia in peritonitis].
    Khirurgiia, 2015, Issue:1

    Topics: Abdominal Cavity; Adult; Algorithms; Drainage; Endotoxemia; Female; Humans; Male; Malondialdehyde; P

2015
Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Blood Urea Nitrogen; Cell Line; Cell

2015
Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury.
    The Tohoku journal of experimental medicine, 2015, Volume: 237, Issue:2

    Topics: Abdomen; Acute Lung Injury; Acute-Phase Proteins; Aged; Creatinine; Critical Care; Disease Progressi

2015
Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1.
    Life sciences, 2016, Dec-01, Volume: 166

    Topics: Acute Lung Injury; Adrenergic beta-Antagonists; Animals; Down-Regulation; Endothelin-1; Lung; Male;

2016
Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration, and oxidative stress.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Deferoxamine; Disease Models, Animal; Kidney; Lung;

2011
Hepatic effects of flunixin-meglumin in LPS-induced sepsis.
    Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:6

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartate Amin

2010
First example of hepatocyte transplantation to alleviate ornithine transcarbamylase deficiency, monitored by NMR-based metabonomics.
    Bioanalysis, 2009, Volume: 1, Issue:9

    Topics: Ammonia; Hepatocytes; Humans; Infant; Infant, Newborn; Liver Transplantation; Magnetic Resonance Spe

2009
Hyperammonemia in the pediatric emergency care setting.
    Pediatric emergency care, 2010, Volume: 26, Issue:12

    Topics: Ammonia; Brain Damage, Chronic; Child; Child, Preschool; Consciousness Disorders; Critical Illness;

2010
A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:2

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Cohort Studies; Creatinine; Critical Illness; Disease

2012
Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study.
    Critical care (London, England), 2011, Jul-27, Volume: 15, Issue:4

    Topics: Acute Kidney Injury; Aged; Biomarkers; Cohort Studies; Critical Illness; Diuretics; Female; Hemodyna

2011
Graft infection in kidney recipients and its relation to transplanted kidney function.
    Transplantation proceedings, 2011, Volume: 43, Issue:8

    Topics: Adolescent; Adult; Child; Creatinine; Female; Humans; Infections; Kidney Diseases; Kidney Function T

2011
Medical image. Septicaemia with acute renal failure.
    The New Zealand medical journal, 2012, Apr-20, Volume: 125, Issue:1353

    Topics: Acute Kidney Injury; Adult; Fatal Outcome; Humans; Kidney Tubules; Male; Necrosis; Sepsis; Sweat; Ur

2012
Twelve-month outcomes of patients admitted to the acute general medical service at Groote Schuur Hospital.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2012, May-23, Volume: 102, Issue:6

    Topics: Activities of Daily Living; Adult; Age Factors; Aged; Confidence Intervals; Employment; Female; Foll

2012
Twelve-month outcomes of patients admitted to the acute general medical service at Groote Schuur Hospital.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2012, May-23, Volume: 102, Issue:6

    Topics: Activities of Daily Living; Adult; Age Factors; Aged; Confidence Intervals; Employment; Female; Foll

2012
Twelve-month outcomes of patients admitted to the acute general medical service at Groote Schuur Hospital.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2012, May-23, Volume: 102, Issue:6

    Topics: Activities of Daily Living; Adult; Age Factors; Aged; Confidence Intervals; Employment; Female; Foll

2012
Twelve-month outcomes of patients admitted to the acute general medical service at Groote Schuur Hospital.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2012, May-23, Volume: 102, Issue:6

    Topics: Activities of Daily Living; Adult; Age Factors; Aged; Confidence Intervals; Employment; Female; Foll

2012
Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study.
    Journal of critical care, 2013, Volume: 28, Issue:4

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Aged; APACHE; Area Under Curve; Biomarkers; Chi-Square Di

2013
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:9

    Topics: Amidohydrolases; Aminopeptidases; Animals; Bacteria; Biotransformation; Crystallography, X-Ray; DNA

2002
Protection against lethal intra-abdominal sepsis by 1-(3-dimethylaminopropyl)-3-ethylurea.
    The Journal of infectious diseases, 2003, Aug-01, Volume: 188, Issue:3

    Topics: Abdominal Abscess; Adjuvants, Immunologic; Animals; Carboxymethylcellulose Sodium; Cytokines; Diseas

2003
[ACUTE AZOTEMIAS DURING INFECTIOUS DISEASES].
    Medicina interna, 1964, Volume: 16

    Topics: Azotemia; Dysentery; Foodborne Diseases; Humans; Infections; Leptospirosis; Nitrogen; Sepsis; Tetanu

1964
EVALUATION OF SIMULTANEOUS SPLIT-COIL HAEMODIALYSIS WITH THE KOLFF TWIN-COIL ARTIFICIAL KIDNEY.
    Lancet (London, England), 1965, Apr-03, Volume: 1, Issue:7388

    Topics: Abortion, Septic; Acute Kidney Injury; Appendectomy; Blood; Cholecystectomy; Female; Hemorrhage; Hum

1965
Successful management of tachycardiac atrial fibrillation in a septic patient with landiolol.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Hemodynamics; Humans; Intraoperative Complication

2005
Release of the mitochondrial enzyme carbamoyl phosphate synthase under septic conditions.
    Shock (Augusta, Ga.), 2005, Volume: 23, Issue:6

    Topics: Animals; Arginine; Bilirubin; Blotting, Western; Carbamoyl-Phosphate Synthase (Ammonia); Electrophor

2005
A 77-year-old woman with sudden onset of blue discolouration of right third toe.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2006, Volume: 12, Issue:1

    Topics: Aged; Blue Toe Syndrome; Creatinine; Dyspnea; Fatal Outcome; Female; Heart Diseases; Humans; Renal I

2006
Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison.
    Journal of perinatology : official journal of the California Perinatal Association, 2006, Volume: 26, Issue:12

    Topics: Amino Acids; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Observation;

2006
Performance of severity of illness scoring systems in emergency department patients with infection.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2007, Volume: 14, Issue:8

    Topics: Adult; Aged; Area Under Curve; Blood Pressure Determination; Emergency Medicine; Emergency Service,

2007
Effect of severity disease on the pharmacokinetics of cefuroxime in children with multiple organ system failure.
    Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:2

    Topics: Adolescent; Alanine Transaminase; Algorithms; Area Under Curve; Aspartate Aminotransferases; Cefurox

2008
Abnormal splitting of the second heart sound in renal failure.
    British medical journal, 1967, Oct-28, Volume: 4, Issue:5572

    Topics: Adult; Bicarbonates; Blood Pressure; Glomerulonephritis; Heart; Hemoglobinometry; Humans; Hypertensi

1967
Urea nitrogen excretion in critically ill children.
    Pediatrics, 1982, Volume: 70, Issue:6

    Topics: Adolescent; Body Surface Area; Child; Child Nutritional Physiological Phenomena; Child, Preschool; D

1982
Hormone effects on hepatic substrate preference in sepsis.
    Shock (Augusta, Ga.), 1994, Volume: 1, Issue:2

    Topics: Alanine; Animals; Energy Metabolism; Gluconeogenesis; Hormones; Lactates; Lactic Acid; Liver; Male;

1994
Functional characteristics of the hypermetabolic isolated perfused liver.
    Shock (Augusta, Ga.), 1996, Volume: 6, Issue:1

    Topics: Adenine Nucleotides; Amino Acids; Animals; Energy Metabolism; Fibrinogen; Glucagon; Glucose; In Vitr

1996
Altered hepatic gene expression in fecal peritonitis: changes in transcription of gluconeogenic, beta-oxidative, and ureagenic genes.
    Shock (Augusta, Ga.), 1997, Volume: 7, Issue:3

    Topics: Administration, Cutaneous; Animals; Carnitine O-Palmitoyltransferase; Cecum; Feces; Gene Expression;

1997
Systemic and splanchnic metabolic response to exogenous human growth hormone.
    Surgery, 1998, Volume: 123, Issue:5

    Topics: APACHE; C-Peptide; C-Reactive Protein; Critical Illness; Energy Intake; Hemodynamics; Human Growth H

1998
Growth requirements and nitrogen metabolism of Malassezia furfur.
    Archives of dermatological research, 1998, Volume: 290, Issue:5

    Topics: Allantoin; Amino Acids; Ammonium Chloride; Ammonium Sulfate; Cell Division; Creatine; Creatinine; Cu

1998
Myoglobin clearance and removal during continuous venovenous hemofiltration.
    Intensive care medicine, 1999, Volume: 25, Issue:10

    Topics: Acrylic Resins; Acute Kidney Injury; Adult; Creatinine; Dehydration; Diabetes Mellitus, Type 2; Hemo

1999
Letter: Uraemia, gram-negative sepsis, and gentamicin assays.
    Lancet (London, England), 1975, Nov-01, Volume: 2, Issue:7940

    Topics: Biological Assay; Culture Media; Evaluation Studies as Topic; Gentamicins; Humans; Sepsis; Urea; Ure

1975
Unusual Enterobacteriaceae. "Proteus rettgeri" that "change" into Providencia stuartii.
    Journal of clinical microbiology, 1977, Volume: 6, Issue:4

    Topics: Aged; Ammonia; Bacteriological Techniques; Carbohydrate Metabolism; Humans; Lactose Factors; Male; P

1977
Glucose-dependent hepatic membrane transport in nonbacteremic and bacteremic thermally injured patients.
    The Journal of surgical research, 1977, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Amino Acids; Biological Transport; Burns; Coloring Agents; Glucose; Humans;

1977
Interrelationship between hepatic ureagenesis and gluconeogenesis in early sepsis.
    The American journal of physiology, 1991, Volume: 260, Issue:3 Pt 1

    Topics: Alanine; Ammonium Chloride; Animals; Gluconeogenesis; Glutamine; In Vitro Techniques; Kinetics; Lact

1991
The encephalopathy associated with septic illness.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1990, Volume: 13, Issue:6

    Topics: Alkaline Phosphatase; Bilirubin; Brain; Brain Diseases; Candida albicans; Creatinine; Electroencepha

1990
Risk factors of the multiple organ failure.
    Progress in clinical and biological research, 1989, Volume: 308

    Topics: Adolescent; Adult; Blood Coagulation Factors; Catecholamines; Creatinine; Female; Humans; Male; Midd

1989
[Evaluation of the efficiency of parenteral nutrition].
    Beitrage zu Infusionstherapie und klinische Ernahrung, 1986, Volume: 13

    Topics: Amino Acids; Blood Glucose; Blood Proteins; Energy Metabolism; Humans; Liver Diseases; Nitrogen; Par

1986
[Value of urea nitrogen in the urine as a discriminating parameter of clinical sepsis].
    Revista medica de Chile, 1987, Volume: 115, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Nitrogen; Sepsis; Ure

1987
Host immune status in uraemia. VI. Leucocytic response to bacterial infection in chronic renal failure.
    Nephron, 1985, Volume: 39, Issue:1

    Topics: Animals; Escherichia coli Infections; Female; Kidney Failure, Chronic; Leukocytes; Lung Diseases; Ma

1985
Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers.
    Surgery, 1985, Volume: 97, Issue:5

    Topics: Adult; Aged; Alanine; Blood Glucose; Candidiasis; Carbon Isotopes; Escherichia coli Infections; Fema

1985
[Successful treatment of Candida septicaemia and interstitial pneumonia].
    Deutsche medizinische Wochenschrift (1946), 1973, Jun-15, Volume: 98, Issue:24

    Topics: Adult; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Benzene Derivatives; Bronchopneumon

1973
Elevation of serum bilirubin and blood urea in pneumonia.
    Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:4

    Topics: Adult; Bilirubin; Creatinine; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Male;

1974
The treatment of hypercatabolic acute renal failure by adequate nutrition and haemodialysis.
    Acta anaesthesiologica Scandinavica, 1974, Volume: 18, Issue:4

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Child; Child, Preschool; Creatinine; Diuresis; Humans;

1974
Waldenstrom's macroglobulinaemia and amyloidosis with subcutaneous calcification and lymphographic appearances.
    The British journal of radiology, 1974, Volume: 47, Issue:556

    Topics: Amyloidosis; Biopsy; Bone Marrow Cells; Calcinosis; Calcium; Cardiomegaly; Cyclophosphamide; Hematoc

1974
[Reputedly nephrotoxic antibiotic therapy during severe infections].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Jul-10, Volume: 48, Issue:31

    Topics: Acute Kidney Injury; Adolescent; Adult; Amphotericin B; Anti-Bacterial Agents; Bacterial Infections;

1972
Editorial: Mid-trimester termination.
    British medical journal, 1974, Aug-17, Volume: 3, Issue:5928

    Topics: Abortion, Therapeutic; Female; Glucose; Humans; Hypernatremia; Hysterectomy; Oxytocin; Pregnancy; Pr

1974
Gram-positive septicaemia in rheumatoid arthritis.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:3

    Topics: Ampicillin; Arthritis, Rheumatoid; Fusidic Acid; Humans; Lincomycin; Male; Middle Aged; Penicillin R

1974
[Successful treatment of candida sepsis with the oral antimycotic Bay b 5097].
    Deutsche medizinische Wochenschrift (1946), 1972, Jun-16, Volume: 97, Issue:24

    Topics: Acute Kidney Injury; Antifungal Agents; Benzene Derivatives; Blood; Candidiasis; Creatinine; Eye Man

1972
Intravascular coagulation and E. coli septicaemia.
    Journal of clinical pathology, 1973, Volume: 26, Issue:2

    Topics: Anemia, Hemolytic; Autopsy; Blood Coagulation Tests; Blood Platelets; Disseminated Intravascular Coa

1973
Serum IgG and renal transplantation.
    British medical journal, 1973, Dec-22, Volume: 4, Issue:5894

    Topics: Adult; Azathioprine; Creatinine; Escherichia coli Infections; Female; Graft Rejection; Hematocrit; H

1973
Traumatic hepatorenal failure. Supportive treatment with simultaneous hemodialysis and exchange transfusion.
    Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 104, Issue:3

    Topics: Acute Kidney Injury; Adult; Bilirubin; Blast Injuries; Blood Urea Nitrogen; Calcium; Citrates; Excha

1972
Neonatal bacteriuria: a prospective study in 1,460 infants.
    British medical journal, 1972, Jan-29, Volume: 1, Issue:5795

    Topics: Bacteriuria; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Leukocyte Count; Male; Pros

1972
Urea as a culture medium enriching agent for the early detection of septicemia in renal failure.
    The American journal of medical technology, 1968, Volume: 34, Issue:1

    Topics: Blood Urea Nitrogen; Culture Media; Humans; Kidney Failure, Chronic; Sepsis; Urea

1968
[The ureic index: clinical guide to mannitol treatment in pediatric surgery].
    Il Policlinico. Sezione pratica, 1969, Volume: 76, Issue:3

    Topics: Acute Kidney Injury; Child; Child, Preschool; Female; Humans; Infant; Male; Mannitol; Postoperative

1969