thyroxine and Autism
thyroxine has been researched along with Autism in 11 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe iodine deficiency during pregnancy can cause intellectual disability, presumably through inadequate placental transfer of maternal thyroid hormone to the fetus." | 7.96 | Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children. ( Bath, SC; Dineva, M; Fano, E; Guxens, M; Ibarluzea, JM; Korevaar, TIM; Levie, D; Llop, S; Murcia, M; Peeters, RP; Rayman, MP; Sunyer, J; Tiemeier, H, 2020) |
| "Transient gestational hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of autism." | 7.79 | Association of gestational maternal hypothyroxinemia and increased autism risk. ( Bongers-Schokking, JJ; de Rijke, YB; Ghassabian, A; Hofman, A; Jaddoe, VW; Román, GC; Tiemeier, H; Verhulst, FC, 2013) |
| "Expression of autism candidates, Gabrb3, Ube3a, Mecp2, and Slc25a12, was significantly increased in the hippocampus of male offspring of EtOH dams." | 5.39 | Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. ( Redei, EE; Shukla, PK; Tunc-Ozcan, E; Ullmann, TM, 2013) |
| "Severe iodine deficiency during pregnancy can cause intellectual disability, presumably through inadequate placental transfer of maternal thyroid hormone to the fetus." | 3.96 | Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children. ( Bath, SC; Dineva, M; Fano, E; Guxens, M; Ibarluzea, JM; Korevaar, TIM; Levie, D; Llop, S; Murcia, M; Peeters, RP; Rayman, MP; Sunyer, J; Tiemeier, H, 2020) |
| "Transient gestational hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of autism." | 3.79 | Association of gestational maternal hypothyroxinemia and increased autism risk. ( Bongers-Schokking, JJ; de Rijke, YB; Ghassabian, A; Hofman, A; Jaddoe, VW; Román, GC; Tiemeier, H; Verhulst, FC, 2013) |
| "Because autism may be a disease of early fetal brain development, maternal hypothyroxinemia (HT) in early pregnancy secondary to iodine deficiency (ID) may be related to etiology of autism." | 3.79 | Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. ( Hamza, RT; Hewedi, DH; Sallam, MT, 2013) |
| "Expression of autism candidates, Gabrb3, Ube3a, Mecp2, and Slc25a12, was significantly increased in the hippocampus of male offspring of EtOH dams." | 1.39 | Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. ( Redei, EE; Shukla, PK; Tunc-Ozcan, E; Ullmann, TM, 2013) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Levie, D | 2 |
| Bath, SC | 2 |
| Guxens, M | 2 |
| Korevaar, TIM | 2 |
| Dineva, M | 2 |
| Fano, E | 1 |
| Ibarluzea, JM | 2 |
| Llop, S | 1 |
| Murcia, M | 2 |
| Rayman, MP | 2 |
| Sunyer, J | 2 |
| Peeters, RP | 2 |
| Tiemeier, H | 4 |
| Dalmau-Bueno, A | 1 |
| Espada, M | 1 |
| Rebagliato, M | 1 |
| Tunc-Ozcan, E | 1 |
| Ullmann, TM | 1 |
| Shukla, PK | 1 |
| Redei, EE | 1 |
| Román, GC | 2 |
| Ghassabian, A | 2 |
| Bongers-Schokking, JJ | 2 |
| Jaddoe, VW | 2 |
| Hofman, A | 2 |
| de Rijke, YB | 2 |
| Verhulst, FC | 2 |
| Hamza, RT | 1 |
| Hewedi, DH | 1 |
| Sallam, MT | 1 |
| Chang, K | 1 |
| Shin, JI | 1 |
| Young, JG | 2 |
| Kyprie, RM | 2 |
| Ross, NT | 1 |
| Cohen, DJ | 2 |
| Abbassi, V | 1 |
| Linscheid, T | 1 |
| Coleman, M | 1 |
| Campbell, M | 1 |
| Small, AM | 1 |
| Hollander, CS | 1 |
| Korein, J | 1 |
| Cohen, IL | 1 |
| Kalmijn, M | 1 |
| Ferris, S | 1 |
Reviews
1 review available for thyroxine and Autism
| Article | Year |
|---|---|
Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: A Meta-Analysis of Individual Participant Data.
Topics: Adult; Autistic Disorder; Child; Child Development; Child, Preschool; Female; Gestational Age; Human | 2018 |
Trials
1 trial available for thyroxine and Autism
| Article | Year |
|---|---|
A controlled crossover study of triiodothyronine in autistic children.
Topics: Autistic Disorder; Brain; Child; Child Behavior; Child, Preschool; Clinical Trials as Topic; Cogniti | 1978 |
Other Studies
9 other studies available for thyroxine and Autism
| Article | Year |
|---|---|
Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child, Preschool; Creatinin | 2020 |
Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression.
Topics: Animals; Autistic Disorder; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Hippocampus; Male; Pr | 2013 |
Association of gestational maternal hypothyroxinemia and increased autism risk.
Topics: Adult; Autistic Disorder; Child; Child, Preschool; Female; Gestational Age; Humans; Hypothyroidism; | 2013 |
Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Egypt; Female; Humans; Intelligence Tests; I | 2013 |
Reply: To PMID 23943579.
Topics: Autistic Disorder; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Prenatal Expo | 2014 |
Association of gestational maternal hypothyroxinemia and increased autism risk: the role of brain-derived neurotrophic factor.
Topics: Autistic Disorder; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Prenatal Expo | 2014 |
Serum dopamine-beta-hydroxylase activity: clinical applications in child psychiatry.
Topics: Adolescent; Adult; Age Factors; Aphasia; Autistic Disorder; Child; Diseases in Twins; Dopamine beta- | 1980 |
Catecholamine-thyroid hormone interactions: III. Serum DBH activity and thyroxine in euthyroid subjects.
Topics: Adolescent; Adult; Aged; Autistic Disorder; Child; Dopamine beta-Hydroxylase; Female; Humans; Langua | 1982 |
Triiodothyronine (T3) concentration and therapy in autistic children.
Topics: Adolescent; Adult; Age Determination by Skeleton; Autistic Disorder; Child; Humans; Hyperthyroidism; | 1978 |