Page last updated: 2024-10-20

taurine and Sepsis

taurine has been researched along with Sepsis in 32 studies

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"This study shows that catheter filling with a solution containing the antimicrobial taurolidine may significantly reduce the incidence of catheter-related sepsis."9.11Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. ( Betjes, MG; van Agteren, M, 2004)
"Although reports of decreased plasma taurine in trauma, sepsis and critical illness are available, very little is known about the relationships among changes in plasma taurine, other amino acid levels and metabolic variables."9.09The relationship between plasma taurine and other amino acid levels in human sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
" We investigated whether taurine, an endogenous antioxidant and vasodilator, could attenuate the deleterious effects of endotoxin in a mouse model of sepsis."7.74The effect of taurine on mesenteric blood flow and organ injury in sepsis. ( Akbiyik, F; Atilla, P; Balkanci, ZD; Cakar, N; Erdem, A; Guc, MO; Iskit, AB; Sevgili, AM, 2008)
"This study has been performed to characterize the relationship between changes in plasma taurine (TAU) and hemodynamic patterns in sepsis."7.70Taurine and pulmonary hemodynamics in sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
"Taurine is an intracellular free amino acid that has anti-inflammatory and antioxidant effects."5.72Mechanism of taurine reducing inflammation and organ injury in sepsis mice. ( Deng, S; Hao, Y; Li, R; Ma, Y; Qin, Q; Ran, C; Zhang, J; Zhang, Y; Zhu, L, 2022)
"The pathogenesis of sepsis is characterized by an overwhelming systemic inflammatory response that can lead to multiple organ failure."5.36Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. ( Cassol, OJ; Dal-Pizzol, F; Ferreira, GK; Gonçalves, CL; Petronilho, FC; Rezin, GT; Roesler, R; Scaini, G; Schwartsmann, G; Streck, EL, 2010)
"[35S]Taurine contents were significantly lower only in kidneys, spleen and gastrointestinal tract of septic rats."5.30Metabolism of cysteine is modified during the acute phase of sepsis in rats. ( Breuillé, D; Malmezat, T; Mirand, PP; Obled, C; Pouyet, C, 1998)
"The incidence and cost of treatment of catheter sepsis occurring in all patients receiving haemodialysis via a line were investigated over 6-month periods before and after introducing the taurolidine/citrate line-locking agent."5.13A new haemodialysis catheter-locking agent reduces infections in haemodialysis patients. ( Cahill, J; Gerrish, M; Little, J; Taylor, C, 2008)
"This study shows that catheter filling with a solution containing the antimicrobial taurolidine may significantly reduce the incidence of catheter-related sepsis."5.11Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. ( Betjes, MG; van Agteren, M, 2004)
"Although reports of decreased plasma taurine in trauma, sepsis and critical illness are available, very little is known about the relationships among changes in plasma taurine, other amino acid levels and metabolic variables."5.09The relationship between plasma taurine and other amino acid levels in human sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
" Taurolock (Bio-Implant HealthCare, Winsen, Germany), which contains taurolidine, is being marketed as a central venous catheter lock solution for decreasing the risk of catheter sepsis."4.84Taurolidine and catheter-related bloodstream infection: a systematic review of the literature. ( Bradshaw, JH; Puntis, JW, 2008)
" Incidence and type of sepsis were reviewed for 8 to 12 months pre- (when heparin was used) and 2 to 33 months postintroduction of the taurolidine catheter lock."3.78Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock. ( Brind, J; Chu, HP; Hill, S; Tomar, R, 2012)
" We investigated whether taurine, an endogenous antioxidant and vasodilator, could attenuate the deleterious effects of endotoxin in a mouse model of sepsis."3.74The effect of taurine on mesenteric blood flow and organ injury in sepsis. ( Akbiyik, F; Atilla, P; Balkanci, ZD; Cakar, N; Erdem, A; Guc, MO; Iskit, AB; Sevgili, AM, 2008)
"This study has been performed to characterize the relationship between changes in plasma taurine (TAU) and hemodynamic patterns in sepsis."3.70Taurine and pulmonary hemodynamics in sepsis. ( Boldrini, G; Castagneto, M; Chiarla, C; Giovannini, I; Siegel, JH, 2000)
"Taurolidine lock was also safe and effective in treating device colonization."1.91Taurolidine lock in the treatment of colonization and infection of totally implanted venous access devices in cancer patients. ( Bottos, P; Brescia, F; Da Ros, V; Fabiani, F; Moreal, C; Nadalini, E; Pittiruti, M; Scoppettuolo, G; Zanier, C, 2023)
"Taurine is an intracellular free amino acid that has anti-inflammatory and antioxidant effects."1.72Mechanism of taurine reducing inflammation and organ injury in sepsis mice. ( Deng, S; Hao, Y; Li, R; Ma, Y; Qin, Q; Ran, C; Zhang, J; Zhang, Y; Zhu, L, 2022)
"Taurine (Tau) is an abundant amino acid in polymorphonuclear leukocytes that react with hypochlorous acid to form taurine chloramine (TauCl) under inflammatory conditions."1.56Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats. ( Dal-Pizzol, F; Dall'igna, DM; Luz, JMD; Michels, M; Vuolo, F, 2020)
"Sepsis was induced by caecum ligation and puncture (CLP)."1.42Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model. ( Chen, J; Ding, C; Gu, G; Hu, D; Li, J; Liu, S; Ren, J; Wang, G; Wu, X; Wu, Y; Zhou, B, 2015)
"The pathogenesis of sepsis is characterized by an overwhelming systemic inflammatory response that can lead to multiple organ failure."1.36Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. ( Cassol, OJ; Dal-Pizzol, F; Ferreira, GK; Gonçalves, CL; Petronilho, FC; Rezin, GT; Roesler, R; Scaini, G; Schwartsmann, G; Streck, EL, 2010)
"After multiple trauma taurine decreased significantly in plasma in thirty-two patients as well as within the neutrophil and does not recover in sepsis."1.33Relationship of taurine and other amino acids in plasma and in neutrophils of septic trauma patients. ( Engel, JM; Hempelmann, G; Kärcher, B; Little, S; Löhr, T; Menges, T; Mühling, J; Weiss, S, 2006)
"[35S]Taurine contents were significantly lower only in kidneys, spleen and gastrointestinal tract of septic rats."1.30Metabolism of cysteine is modified during the acute phase of sepsis in rats. ( Breuillé, D; Malmezat, T; Mirand, PP; Obled, C; Pouyet, C, 1998)
"Taurolidine is an anti-infective agent with an unusually broad spectrum of effectivity against gram-positive and gram-negative bacteria, anaerobic organisms, and fungi."1.30[The influence of taurolidine on physiological and pathological blood coagulation and implications for its use]. ( Reinmüller, J, 1999)
" However, by increasing the dosage of taurolin, survival is prolonged and mortality reduced."1.26The in vitro and in vivo activity of taurolin against anaerobic pathogenic organisms. ( Brodhage, H; Browne, MK; Leslie, GB; Pfirrman, RW, 1977)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.13)18.7374
1990's3 (9.38)18.2507
2000's11 (34.38)29.6817
2010's8 (25.00)24.3611
2020's9 (28.13)2.80

Authors

AuthorsStudies
van den Bosch, CH1
Jeremiasse, B1
van der Bruggen, JT1
Frakking, FNJ1
Loeffen, YGT1
van de Ven, CP1
van der Steeg, AFW1
Fiocco, MF1
van de Wetering, MD1
Wijnen, MHWA1
Vernon-Roberts, A1
Lopez, RN1
Frampton, CM1
Day, AS1
Ma, Y1
Zhang, Y1
Li, R1
Deng, S1
Qin, Q1
Ran, C1
Hao, Y1
Zhang, J1
Zhu, L1
Huang, J1
Ita, M1
Zhou, H1
Zhao, H1
Hassan, F1
Bai, Z1
O'Leary, DP1
Li, Y1
Redmond, HP1
Wang, JH1
Wang, J2
Supinski, GS1
Wang, L1
Schroder, EA1
Callahan, LAP1
Xu, D1
Liao, S1
Lv, Y1
Kong, L1
Dall'igna, DM1
Luz, JMD1
Vuolo, F1
Michels, M1
Dal-Pizzol, F2
Brescia, F1
Pittiruti, M1
Scoppettuolo, G1
Zanier, C1
Nadalini, E1
Bottos, P1
Moreal, C1
Da Ros, V1
Fabiani, F1
Chen, J2
Xue, X2
Cai, J1
Jia, L2
Sun, B1
Zhao, W2
Yang, HJ1
Xu, WX1
Cai, JQ1
Guo, RJ1
Cao, CC1
Klek, S2
Szczepanek, K2
Hermanowicz, A1
Galas, A1
Wu, Y1
Ren, J1
Zhou, B1
Ding, C1
Wang, G1
Gu, G1
Wu, X1
Liu, S1
Hu, D1
Li, J1
Olthof, ED1
Broekman, MM1
Wanten, GJ1
Bradshaw, JH1
Puntis, JW1
Taylor, C1
Cahill, J1
Gerrish, M1
Little, J1
Cassol, OJ1
Rezin, GT1
Petronilho, FC1
Scaini, G1
Gonçalves, CL1
Ferreira, GK1
Roesler, R1
Schwartsmann, G1
Streck, EL1
Chu, HP1
Brind, J1
Tomar, R1
Hill, S1
Xu, ZW1
Li, YS1
Manocha, S1
Feinstein, D1
Kumar, A2
Betjes, MG1
van Agteren, M1
Engel, JM1
Mühling, J1
Weiss, S1
Kärcher, B1
Löhr, T1
Menges, T1
Little, S1
Hempelmann, G1
Erdem, A1
Sevgili, AM1
Akbiyik, F1
Atilla, P1
Cakar, N1
Balkanci, ZD1
Iskit, AB1
Guc, MO1
Malmezat, T1
Breuillé, D1
Pouyet, C1
Mirand, PP1
Obled, C1
Reinmüller, J1
Hung, CR1
Hung, PC1
Chiarla, C2
Giovannini, I2
Siegel, JH2
Boldrini, G2
Castagneto, M2
Sodemann, K1
Polaschegg, HD1
Feldmer, B1
Quarello, F1
Forneris, G1
Btaiche, IF1
Khalidi, N1
Browne, MK1
Leslie, GB1
Pfirrman, RW1
Brodhage, H1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Randomized, Controlled Trial Evaluating the Efficacy of a Lock-therapy With a Solution of Taurolidine/Citrate (TauroLock) vs Standard Saline Solution for the Primary Prevention of Catheter-related Infections (CLI) in Adult Patients Wtih a Non[NCT02279121]162 participants (Actual)Interventional2014-11-30Completed
A Randomised Study of Taurolock for the Locking of Tunneled Central Venous Catheters in Children With Malignant Diseases.[NCT00735813]Phase 3129 participants (Actual)Interventional2008-04-30Completed
Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants[NCT00711763]1 participants (Actual)Observational2008-07-31Terminated (stopped due to failure to recruit more patients and lack of supporting personnel.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for taurine and Sepsis

ArticleYear
The efficacy of taurolidine containing lock solutions for the prevention of central-venous-catheter-related bloodstream infections: a systematic review and meta-analysis.
    The Journal of hospital infection, 2022, Volume: 123

    Topics: Catheter-Related Infections; Catheterization, Central Venous; Central Venous Catheters; Humans; Rand

2022
Meta-analysis of the efficacy of taurolidine in reducing catheter-related bloodstream infections for patients receiving parenteral nutrition.
    JPEN. Journal of parenteral and enteral nutrition, 2022, Volume: 46, Issue:7

    Topics: Catheter-Related Infections; Catheterization, Central Venous; Central Venous Catheters; Humans; Pare

2022
Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.
    Journal of pediatric gastroenterology and nutrition, 2008, Volume: 47, Issue:2

    Topics: Anti-Infective Agents; Catheterization, Central Venous; Equipment Contamination; Evidence-Based Medi

2008
Pathogenesis and treatment of parenteral nutrition-associated liver disease.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2012, Dec-15, Volume: 11, Issue:6

    Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Enteral Nutrition; Fat Emulsion

2012
Novel therapies for sepsis: antiendotoxin therapies.
    Expert opinion on investigational drugs, 2002, Volume: 11, Issue:12

    Topics: Acute-Phase Proteins; Antibodies, Monoclonal; Carrier Proteins; Endotoxins; Humans; Lipopolysacchari

2002
Prevention of hemodialysis catheter-related bloodstream infection using an antimicrobial lock.
    Blood purification, 2002, Volume: 20, Issue:1

    Topics: Anti-Infective Agents, Local; Catheters, Indwelling; Citric Acid; Equipment Contamination; Equipment

2002
Parenteral nutrition-associated liver complications in children.
    Pharmacotherapy, 2002, Volume: 22, Issue:2

    Topics: Alkaline Phosphatase; Anti-Bacterial Agents; Bilirubin; Carnitine; Child; Cholestasis; gamma-Glutamy

2002

Trials

4 trials available for taurine and Sepsis

ArticleYear
Taurolidine lock in home parenteral nutrition in adults: results from an open-label randomized controlled clinical trial.
    JPEN. Journal of parenteral and enteral nutrition, 2015, Volume: 39, Issue:3

    Topics: Adult; Anti-Infective Agents; Bacteremia; Catheter-Related Infections; Catheterization, Central Veno

2015
A new haemodialysis catheter-locking agent reduces infections in haemodialysis patients.
    Journal of renal care, 2008, Volume: 34, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Catheters, Indwelling; Chi-Square Dist

2008
Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6

    Topics: Anti-Infective Agents; Bacterial Infections; Catheterization, Central Venous; Catheters, Indwelling;

2004
Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6

    Topics: Anti-Infective Agents; Bacterial Infections; Catheterization, Central Venous; Catheters, Indwelling;

2004
Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6

    Topics: Anti-Infective Agents; Bacterial Infections; Catheterization, Central Venous; Catheters, Indwelling;

2004
Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6

    Topics: Anti-Infective Agents; Bacterial Infections; Catheterization, Central Venous; Catheters, Indwelling;

2004
The relationship between plasma taurine and other amino acid levels in human sepsis.
    The Journal of nutrition, 2000, Volume: 130, Issue:9

    Topics: Adult; Amino Acids; Female; Humans; Injury Severity Score; Male; Parenteral Nutrition, Total; Regres

2000

Other Studies

21 other studies available for taurine and Sepsis

ArticleYear
Mechanism of taurine reducing inflammation and organ injury in sepsis mice.
    Cellular immunology, 2022, Volume: 375

    Topics: Animals; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophils; Sepsis; Taurine;

2022
Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance.
    Proceedings of the National Academy of Sciences of the United States of America, 2022, 05-10, Volume: 119, Issue:19

    Topics: Animals; Autophagy; Mice; Phagocytosis; Sepsis; Taurine; Thiadiazines

2022
Taurine administration ablates sepsis induced diaphragm weakness.
    Respiratory physiology & neurobiology, 2020, Volume: 271

    Topics: Animals; Diaphragm; Mice; Muscle Weakness; Oxidative Stress; Sepsis; Taurine

2020
NMR-based metabolomics approach reveals effects of antioxidant nutrients in sepsis-induced changes in rat liver injury.
    The Journal of nutritional biochemistry, 2020, Volume: 85

    Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Glutathione; Liver Diseases; Magnetic

2020
Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats.
    Anais da Academia Brasileira de Ciencias, 2020, Volume: 92, Issue:4

    Topics: Animals; Cell Survival; Cells, Cultured; Cytokines; Lymphocytes; Rats; Sepsis; Spleen; Taurine

2020
Taurolidine lock in the treatment of colonization and infection of totally implanted venous access devices in cancer patients.
    The journal of vascular access, 2023, Volume: 24, Issue:1

    Topics: Catheter-Related Infections; Catheterization, Central Venous; Central Venous Catheters; Humans; Neop

2023
Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway.
    Molecular medicine reports, 2021, Volume: 24, Issue:3

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Imidazoles; Lung; Male; Malondialdehyde; MAP Kin

2021
Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Acute Lung Injury; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Immune System; Inflammation; Ki-6

2018
Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model.
    Clinical and experimental immunology, 2015, Volume: 179, Issue:2

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cytokines; Gene Silencing; Glycine; Hepatocytes; Hy

2015
Do we know the benefits of a taurolidine lock in adult home parenteral nutrition patients with a low infection rate?
    JPEN. Journal of parenteral and enteral nutrition, 2015, Volume: 39, Issue:4

    Topics: Anti-Infective Agents; Catheter-Related Infections; Catheterization, Central Venous; Central Venous

2015
Response to Olthof et al.
    JPEN. Journal of parenteral and enteral nutrition, 2015, Volume: 39, Issue:4

    Topics: Anti-Infective Agents; Catheter-Related Infections; Catheterization, Central Venous; Central Venous

2015
Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis.
    Neurochemical research, 2010, Volume: 35, Issue:4

    Topics: Acetylcysteine; Animals; Bombesin; Brain; Creatine Kinase; Deferoxamine; Electron Transport; Male; P

2010
Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Anti-Infective Agents; Anticoagulants; Catheter-Related Infections; Catheterizati

2012
Relationship of taurine and other amino acids in plasma and in neutrophils of septic trauma patients.
    Amino acids, 2006, Volume: 30, Issue:1

    Topics: Adult; Amino Acids; Aspartic Acid; Glutamic Acid; Humans; Middle Aged; Neutrophils; Retrospective St

2006
The effect of taurine on mesenteric blood flow and organ injury in sepsis.
    Amino acids, 2008, Volume: 35, Issue:2

    Topics: Animals; Blood Flow Velocity; Disease Models, Animal; Endotoxins; Free Radicals; Glutathione; Inject

2008
Metabolism of cysteine is modified during the acute phase of sepsis in rats.
    The Journal of nutrition, 1998, Volume: 128, Issue:1

    Topics: Acute-Phase Reaction; Animals; Body Weight; Cysteine; Escherichia coli Infections; Glutathione; Male

1998
[The influence of taurolidine on physiological and pathological blood coagulation and implications for its use].
    Zentralblatt fur Chirurgie, 1999, Volume: 124 Suppl 4

    Topics: Anti-Infective Agents, Local; Bacterial Infections; Blood Coagulation; Gram-Negative Bacteria; Gram-

1999
Protective effects of several amino acid-nutrients on gastric hemorrhagic erosions in acid-irrigated stomachs of septic rats.
    The Chinese journal of physiology, 1999, Sep-30, Volume: 42, Issue:3

    Topics: Acids; Amino Acids; Animals; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric

1999
Taurine and pulmonary hemodynamics in sepsis.
    Amino acids, 2000, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Amino Acids; Atrial Function, Right; Blood Pressure; Female; Hemodynamics; Humans

2000
Two years' experience with Dialock and CLS (a new antimicrobial lock solution).
    Blood purification, 2001, Volume: 19, Issue:2

    Topics: Adult; Anti-Infective Agents; Anticoagulants; Catheterization, Central Venous; Catheters, Indwelling

2001
The in vitro and in vivo activity of taurolin against anaerobic pathogenic organisms.
    Surgery, gynecology & obstetrics, 1977, Volume: 145, Issue:6

    Topics: Animals; Bacterial Infections; Bacteroides; Bacteroides Infections; Clostridium Infections; Clostrid

1977