Page last updated: 2024-10-20

taurine and Depression

taurine has been researched along with Depression in 27 studies

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" Acamprosate, although not approved in the United States, is used in alcoholism treatment in many other parts of the world."10.19Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. ( Kranzler, HR; Van Kirk, J, 2001)
"Data were collected during an 8-week randomized controlled trial of acamprosate for individuals with co-occurring bipolar disorder and alcohol dependence (n = 30)."9.16Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate. ( Brady, KT; Brown, DG; Chiuzan, C; DeSantis, SM; Prisciandaro, JJ; Tolliver, BK, 2012)
"This study was conducted to investigate the correlation between dietary taurine intake, nutrients intake, dietary attitudes, dietary behaviors, and life stress by depression in Korean female college students."7.91Relationship Among Dietary Taurine Intake, Dietary Attitudes, Dietary Behaviors, and Life Stress by Depression in Korean Female College Students. ( Chang, KJ; Kim, SH; Oh, EY; Park, SH, 2019)
"The purpose of this study was to investigate the dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students."7.76Dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students: a case-control study. ( Chang, KJ; Park, JY; You, JS, 2010)
" Acamprosate, although not approved in the United States, is used in alcoholism treatment in many other parts of the world."6.19Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. ( Kranzler, HR; Van Kirk, J, 2001)
"Taurine is an important amino acid required for brain development."5.91Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss. ( Cai, G; Fan, Z; Han, J; Li, X; Li, Y; Luo, D; Wang, R; Wu, S; Zhang, H; Zhang, L; Zhu, Y; Zhuo, L, 2023)
"Taurine has been known to be related to certain modifications of the immune system."5.32Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine. ( Baccichet, E; Carreira, I; Lima, L; Obregón, F; Peña, S; Urbina, M, 2003)
"Data were collected during an 8-week randomized controlled trial of acamprosate for individuals with co-occurring bipolar disorder and alcohol dependence (n = 30)."5.16Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate. ( Brady, KT; Brown, DG; Chiuzan, C; DeSantis, SM; Prisciandaro, JJ; Tolliver, BK, 2012)
"The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials."5.11Pharmacological relapse prevention of alcoholism: clinical predictors of outcome. ( Helwig, H; Jahn, H; Kiefer, F; Otte, C; Tarnaske, T; Wiedemann, K, 2005)
"We investigated the antidepressant effect of creatine (CRE) and taurine (TAU) mixtures on behavioural changes and biomarkers in stress-induced depression in Drosophila melanogaster and a mouse model."3.96Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. ( Hong, KB; Jo, K; Kim, S; Suh, HJ, 2020)
"The combination of acamprosate and escitalopram suppressed EtOH intake in both nonstressed and stressed mice; hence, this combination is potentially helpful for AUD individuals with or without comorbid depression to reduce alcohol use."3.83Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice. ( Aguiar, FS; Choi, DS; Hinton, DJ; Ho, AM; Jia, YF; Karpyak, VM; Qiu, Y; Weinshilboum, RM, 2016)
"Responder rates for the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and Mini-Mental State Examination (MMSE) were measured as improvement or absence of decline from baseline."2.72Vagus nerve stimulation in patients with Alzheimer's disease: Additional follow-up results of a pilot study through 1 year. ( Ben-Menachem, E; Blennow, K; C-son Silander, H; Ejnell, H; Jonsson, MA; Karlsson, M; Merrill, CA; Minthon, L; Nordlund, A; Rolstad, S; Sjögren, MJ; Warkentin, S, 2006)
" This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies."2.53Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions. ( Fu, W; Liu, J; Wang, Y, 2016)
"Taurine is an important amino acid required for brain development."1.91Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss. ( Cai, G; Fan, Z; Han, J; Li, X; Li, Y; Luo, D; Wang, R; Wu, S; Zhang, H; Zhang, L; Zhu, Y; Zhuo, L, 2023)
"Taurine was found to inhibit the decrease of sucrose consumption and prevent the deficiency of spatial memory and anxiety in rats exposed to CUMS, suggesting a preventive effect of taurine on depression-like behavior."1.46Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats. ( Feng, Y; Hu, JM; Lin, SM; Ren, S; Tang, RY; Wu, GF; Xu, C; Yang, JC; Yang, QH; Zhou, JQ, 2017)
"A well-validated animal model of treatment resistant depression (congenital learned helpless rats = cLH) was investigated by hippocampal in vivo ¹H MRS with and without a 1-week course of electroconvulsive shocks (ECS), an animal model of ECT, and compared to wild type (WT) animals, while saline and clomipramine injections served as additional controls."1.38Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression. ( Biedermann, S; Ende, G; Gass, P; Hoyer, C; Sartorius, A; Vollmayr, B; Weber-Fahr, W; Zheng, L, 2012)
"Taurine has been shown to be elevated in plasma and lymphocytes of depressed patients, but the level normalises after successful drug therapy."1.38Taurine and glutathione levels in plasma before and after ECT treatment. ( Gerdin, G; Ollinger, K; Samuelsson, M; Vrethem, M, 2012)
"Comorbidity of alcohol abuse and dependence with bipolar disorders is high."1.38Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.). ( Preuss, UW, 2012)
"Taurine has been known to be related to certain modifications of the immune system."1.32Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine. ( Baccichet, E; Carreira, I; Lima, L; Obregón, F; Peña, S; Urbina, M, 2003)
"Lethargy and mental depression are early symptoms, followed by mild parkinsonism and progressive weight loss."1.26Familial fatal Parkinsonism with alveolar hypoventilation and mental depression. ( Ahmad, D; Barnett, HJ; Bratty, P; Hahn, A; Lloyd, KG; McGeer, EG; Perry, TL; Purdy, A, 1979)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's1 (3.70)18.2507
2000's5 (18.52)29.6817
2010's14 (51.85)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Zhu, Y1
Wang, R1
Fan, Z1
Luo, D1
Cai, G1
Li, X1
Han, J1
Zhuo, L1
Zhang, L1
Zhang, H1
Li, Y1
Wu, S1
Park, SH1
Oh, EY1
Kim, SH1
Chang, KJ2
Jangra, A1
Rajput, P1
Dwivedi, DK1
Lahkar, M1
Kim, S2
Hong, KB1
Suh, HJ1
Jo, K1
Wu, GF1
Ren, S1
Tang, RY1
Xu, C1
Zhou, JQ1
Lin, SM1
Feng, Y1
Yang, QH1
Hu, JM1
Yang, JC1
de Dios, I1
Rialp, G1
Franco, S1
Romero, M1
Ortega, M1
Nieto, Y1
Sekar, S1
Grandjean, J1
Garnell, JF1
Willems, R1
Duytschaever, H1
Seramani, S1
Su, H1
Ver Donck, L1
Bhakoo, KK1
Wang, Y1
Fu, W1
Liu, J1
Ho, AM1
Qiu, Y1
Jia, YF1
Aguiar, FS1
Hinton, DJ1
Karpyak, VM1
Weinshilboum, RM1
Choi, DS1
Park, JY1
You, JS1
Biedermann, S1
Weber-Fahr, W1
Zheng, L1
Hoyer, C1
Vollmayr, B1
Gass, P1
Ende, G1
Sartorius, A1
Prisciandaro, JJ1
DeSantis, SM1
Chiuzan, C1
Brown, DG1
Brady, KT1
Tolliver, BK1
Caletti, G1
Olguins, DB1
Pedrollo, EF1
Barros, HM1
Gomez, R1
Samuelsson, M1
Gerdin, G1
Ollinger, K1
Vrethem, M1
Iio, W1
Matsukawa, N1
Tsukahara, T1
Toyoda, A1
Preuss, UW1
Pałucha-Poniewiera, A1
Pilc, A1
Lima, L1
Obregón, F1
Urbina, M1
Carreira, I1
Baccichet, E1
Peña, S1
Kiefer, F1
Helwig, H1
Tarnaske, T1
Otte, C1
Jahn, H1
Wiedemann, K1
Merrill, CA1
Jonsson, MA1
Minthon, L1
Ejnell, H1
C-son Silander, H1
Blennow, K1
Karlsson, M1
Nordlund, A1
Rolstad, S1
Warkentin, S1
Ben-Menachem, E1
Sjögren, MJ1
Soyka, M1
Roesner, S1
Swift, RM1
Kranzler, HR1
Van Kirk, J1
Purdy, A1
Hahn, A1
Barnett, HJ1
Bratty, P1
Ahmad, D1
Lloyd, KG1
McGeer, EG1
Perry, TL2
Tachiki, KH1
Hendrie, HC1
Kellams, J1
Aprison, MH1
Bratty, PJ1
Hansen, S1
Kennedy, J1
Urquhart, N1
Dolman, CL1
Avery, MD1
Lupien, PJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]Phase 254 participants (Actual)Interventional2017-08-07Completed
Effect of Taurine on Glycemic, Lipid and Inflammatory Profile in Individuals With Type 2 Diabetes: a Randomized Clinical Trial[NCT04874012]Phase 294 participants (Anticipated)Interventional2021-06-12Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Prefrontal GABA+ Concentrations

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine3.90
Gabapentin3.93
Placebo Oral Tablet3.73

Prefrontal Glx Concentrations

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Interventionmmol/kg (Mean)
N-Acetylcysteine21.59
Gabapentin21.69
Placebo Oral Tablet22.25

Reviews

4 reviews available for taurine and Depression

ArticleYear
Neurodevelopment in children with intrauterine growth restriction: adverse effects and interventions.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:4

    Topics: Adult; Antioxidants; Brain; Cerebral Palsy; Child; Cognition Disorders; Depression; Developmental Di

2016
New pharmacological approaches for the treatment of alcoholism.
    Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:17

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Carbamazepine; Depression; Disease Models, Ani

2006
The pharmacological treatment of alcohol dependence.
    Medicine and health, Rhode Island, 1997, Volume: 80, Issue:3

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Antidepressive Agents; Comorbidity; Depression; Disulfi

1997
Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:9

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Depression; Female; gamma-Glutamyltransferase; Humans;

2001

Trials

4 trials available for taurine and Depression

ArticleYear
Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate.
    Alcoholism, clinical and experimental research, 2012, Volume: 36, Issue:3

    Topics: Acamprosate; Adolescent; Adult; Aged; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Behavior, Ad

2012
Pharmacological relapse prevention of alcoholism: clinical predictors of outcome.
    European addiction research, 2005, Volume: 11, Issue:2

    Topics: Acamprosate; Adolescent; Adult; Aged; Alcohol Deterrents; Alcoholism; Anxiety Disorders; Depression;

2005
Vagus nerve stimulation in patients with Alzheimer's disease: Additional follow-up results of a pilot study through 1 year.
    The Journal of clinical psychiatry, 2006, Volume: 67, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cholinesterase Inhibi

2006
Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:9

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Depression; Female; gamma-Glutamyltransferase; Humans;

2001

Other Studies

20 other studies available for taurine and Depression

ArticleYear
Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
    Cellular and molecular neurobiology, 2023, Volume: 43, Issue:2

    Topics: Amino Acids; Animals; Dendritic Spines; Depression; Depressive Disorder, Major; Mice; Mice, Inbred C

2023
Relationship Among Dietary Taurine Intake, Dietary Attitudes, Dietary Behaviors, and Life Stress by Depression in Korean Female College Students.
    Advances in experimental medicine and biology, 2019, Volume: 1155

    Topics: Attitude; Case-Control Studies; Cross-Sectional Studies; Depression; Diet; Female; Humans; Republic

2019
Amelioration of Repeated Restraint Stress-Induced Behavioral Deficits and Hippocampal Anomalies with Taurine Treatment in Mice.
    Neurochemical research, 2020, Volume: 45, Issue:4

    Topics: Acetylcholinesterase; Animals; Anxiety; Behavior, Animal; Depression; Hippocampus; Interleukin-1beta

2020
Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways.
    Scientific reports, 2020, 07-09, Volume: 10, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Catecholamines;

2020
Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats.
    Scientific reports, 2017, 07-10, Volume: 7, Issue:1

    Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dopamine; Fibroblast Growth Fact

2017
The role of chronic nutritional supplements consumption in a fulminant serotonin syndrome due to citalopram intoxication.
    Medicina intensiva, 2019, Volume: 43, Issue:9

    Topics: Adult; Alcohol Drinking; Antidepressive Agents, Second-Generation; Citalopram; Depression; Dietary S

2019
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy.
    Neuropharmacology, 2019, 03-01, Volume: 146

    Topics: Anhedonia; Animals; Choline; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists;

2019
Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:7

    Topics: Acamprosate; Alcohol Drinking; Animals; Anxiety; Citalopram; Depression; Drug Therapy, Combination;

2016
Dietary taurine intake, nutrients intake, dietary habits and life stress by depression in Korean female college students: a case-control study.
    Journal of biomedical science, 2010, Aug-24, Volume: 17 Suppl 1

    Topics: Asian People; Body Composition; Body Mass Index; Case-Control Studies; Depression; Diet; Energy Inta

2010
Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2012, Volume: 13, Issue:6

    Topics: Animals; Choline; Depression; Disease Models, Animal; Electroconvulsive Therapy; gamma-Aminobutyric

2012
Antidepressant effect of taurine in diabetic rats.
    Amino acids, 2012, Volume: 43, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Depression; Diabetes Mellitus, Experi

2012
Taurine and glutathione levels in plasma before and after ECT treatment.
    Psychiatry research, 2012, Jun-30, Volume: 198, Issue:1

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Depression; Electroconvulsive Therapy; Female; Gl

2012
The effects of oral taurine administration on behavior and hippocampal signal transduction in rats.
    Amino acids, 2012, Volume: 43, Issue:5

    Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Calcium-Calmodulin-Dependent

2012
Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).
    Alcoholism, clinical and experimental research, 2012, Volume: 36, Issue:6

    Topics: Alcohol Drinking; Alcoholism; Behavior, Addictive; Bipolar Disorder; Depression; Female; Humans; Mal

2012
Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Oct-01, Volume: 39, Issue:1

    Topics: Acamprosate; Animals; Antidepressive Agents; Benzamides; Depression; Disease Models, Animal; Dose-Re

2012
Taurine concentration in human blood peripheral lymphocytes: major depression and treatment with the antidepressant mirtazapine.
    Advances in experimental medicine and biology, 2003, Volume: 526

    Topics: Adolescent; Adult; Depression; Female; Humans; Lymphocytes; Male; Mianserin; Middle Aged; Mirtazapin

2003
Familial fatal Parkinsonism with alveolar hypoventilation and mental depression.
    Annals of neurology, 1979, Volume: 6, Issue:6

    Topics: Brain; Brain Chemistry; Depression; Dopa Decarboxylase; Dopamine; gamma-Aminobutyric Acid; Glutamate

1979
A rapid column chromatographic procedure for the routine measurement of taurine in plasma of normals and depressed patients.
    Clinica chimica acta; international journal of clinical chemistry, 1977, Mar-15, Volume: 75, Issue:3

    Topics: Adult; Animals; Autoanalysis; Chromatography, Ion Exchange; Depression; Humans; Rabbits; Reference V

1977
Hereditary mental depression and Parkinsonism with taurine deficiency.
    Archives of neurology, 1975, Volume: 32, Issue:2

    Topics: Age Factors; Aged; Antidepressive Agents; Body Weight; Brain; Depression; Electroconvulsive Therapy;

1975
Cholesterol metabolism and vitamin B6. II. Intestinal cholesterogenesis in vitamin B6 deficient rats.
    Lipids, 1970, Volume: 5, Issue:1

    Topics: Acetates; Animals; Bile Acids and Salts; Carbon Dioxide; Carbon Isotopes; Cholesterol; Depression; H

1970