Page last updated: 2024-10-20
spermine and Sepsis
spermine has been researched along with Sepsis in 14 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the safety, tolerability, pharmacokinetics, and efficacy of kukoamine B (KB), an alkaloid compound with high affinity for both lipopolysaccharide (LPS) and oligodeoxynucle-otides containing CpG motifs (CpG DNA), in patients with sepsis-induced organ failure." | 9.69 | Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial. ( Chen, S; Dong, K; Du, B; Feng, Y; Hu, P; Hu, XY; Hu, Z; Jiang, W; Jin, C; Liu, H; Sun, Y; Wang, CY; Wang, D; Wang, H; Wang, T; Yao, X; Zang, B; Zhang, W; Zhao, Q; Zhou, J, 2023) |
| "To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients." | 9.51 | Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation. ( Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022) |
| " In this report, we developed microparticles based on polymerization of alpha-ketoglutarate (a Krebs cycle metabolite), with or without encapsulation of spermine (a polyamine metabolite), to modulate cell phenotype that are critical for resolution of inflammation." | 8.31 | Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models. ( Acharya, AP; de Ávila, C; Esrafili, A; Fryer, JD; Halim, M; Inamdar, S; Jaggarapu, MMCS; Lintecum, K; Mantri, S; Ng, ND; Schmitzer, E; Spiller, KL; Suresh, AP; Thumsi, A; Tylek, T; Xu, Y, 2023) |
| "To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism." | 7.80 | [Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014) |
| "To evaluate the safety, tolerability, pharmacokinetics, and efficacy of kukoamine B (KB), an alkaloid compound with high affinity for both lipopolysaccharide (LPS) and oligodeoxynucle-otides containing CpG motifs (CpG DNA), in patients with sepsis-induced organ failure." | 5.69 | Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial. ( Chen, S; Dong, K; Du, B; Feng, Y; Hu, P; Hu, XY; Hu, Z; Jiang, W; Jin, C; Liu, H; Sun, Y; Wang, CY; Wang, D; Wang, H; Wang, T; Yao, X; Zang, B; Zhang, W; Zhao, Q; Zhou, J, 2023) |
| "To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients." | 5.51 | Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation. ( Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022) |
| "It is thus a promising strategy to treat sepsis by discovering agents that neutralize LPS and CpG DNA simultaneously." | 5.37 | Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
| "The present drugs for treating sepsis act only against either LPS or CpG DNA." | 5.37 | Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
| " In this report, we developed microparticles based on polymerization of alpha-ketoglutarate (a Krebs cycle metabolite), with or without encapsulation of spermine (a polyamine metabolite), to modulate cell phenotype that are critical for resolution of inflammation." | 4.31 | Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models. ( Acharya, AP; de Ávila, C; Esrafili, A; Fryer, JD; Halim, M; Inamdar, S; Jaggarapu, MMCS; Lintecum, K; Mantri, S; Ng, ND; Schmitzer, E; Spiller, KL; Suresh, AP; Thumsi, A; Tylek, T; Xu, Y, 2023) |
| "To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism." | 3.80 | [Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014) |
| "It is thus a promising strategy to treat sepsis by discovering agents that neutralize LPS and CpG DNA simultaneously." | 1.37 | Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
| "The present drugs for treating sepsis act only against either LPS or CpG DNA." | 1.37 | Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
| "Sepsis, otherwise referred to as "blood poisoning" is a serious clinical problem, the incidence of which continues to rise in the US and worldwide despite advances in antimicrobial chemotherapy." | 1.36 | Development of small-molecule endotoxin sequestering agents. ( David, SA; Sil, D, 2010) |
| "1 cells, as well as TNF-alpha in human blood, is inhibited in a dose-dependent manner by 4e at concentrations orders of magnitude lower than toxic doses." | 1.33 | Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines. ( Cromer, JR; Datta, A; David, SA; Miller, KA; Suresh Kumar, EV; Wood, SJ, 2005) |
| "Sepsis was induced by cecal ligation and puncture (CLP); control rats were sham-operated." | 1.29 | Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats. ( Fischer, JE; Hasselgren, PO; Meyer, TA; Noguchi, Y; Ogle, CK; Tiao, G, 1996) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Miller, KA | 2 |
| Suresh Kumar, EV | 1 |
| Wood, SJ | 2 |
| Cromer, JR | 2 |
| Datta, A | 1 |
| David, SA | 5 |
| Wang, H | 2 |
| Wang, T | 2 |
| Hu, X | 1 |
| Deng, C | 1 |
| Jiang, J | 1 |
| Qin, H | 1 |
| Dong, K | 2 |
| Chen, S | 2 |
| Jin, C | 2 |
| Zhao, Q | 2 |
| Du, B | 2 |
| Hu, P | 2 |
| Inamdar, S | 1 |
| Tylek, T | 1 |
| Thumsi, A | 1 |
| Suresh, AP | 1 |
| Jaggarapu, MMCS | 1 |
| Halim, M | 1 |
| Mantri, S | 1 |
| Esrafili, A | 1 |
| Ng, ND | 1 |
| Schmitzer, E | 1 |
| Lintecum, K | 1 |
| de Ávila, C | 1 |
| Fryer, JD | 1 |
| Xu, Y | 1 |
| Spiller, KL | 1 |
| Acharya, AP | 1 |
| Hu, XY | 1 |
| Zhang, W | 1 |
| Wang, D | 1 |
| Sun, Y | 1 |
| Hu, Z | 1 |
| Zang, B | 1 |
| Feng, Y | 1 |
| Zhou, J | 1 |
| Liu, H | 1 |
| Jiang, W | 1 |
| Wang, CY | 1 |
| Yao, X | 1 |
| Zhang, J | 2 |
| Qin, W | 2 |
| Lyu, W | 2 |
| Shen, W | 2 |
| Wang, X | 2 |
| Sun, B | 2 |
| Shrestha, A | 1 |
| Sil, D | 2 |
| Malladi, SS | 1 |
| Warshakoon, HJ | 1 |
| Liu, X | 2 |
| Zheng, X | 2 |
| Long, Y | 2 |
| Cao, H | 2 |
| Wang, N | 2 |
| Lu, Y | 2 |
| Zhao, K | 2 |
| Zhou, H | 2 |
| Zheng, J | 2 |
| Burns, MR | 1 |
| Nguyen, T | 1 |
| Shelton, JL | 1 |
| Wang, L | 1 |
| Cepinskas, G | 1 |
| Sandig, M | 1 |
| Scott, JA | 1 |
| North, ML | 1 |
| Inculet, R | 1 |
| Mehta, S | 1 |
| Noguchi, Y | 1 |
| Meyer, TA | 1 |
| Tiao, G | 1 |
| Ogle, CK | 1 |
| Fischer, JE | 1 |
| Hasselgren, PO | 1 |
| Silverstein, R | 1 |
| Amura, CR | 1 |
| Kielian, T | 1 |
| Morrison, DC | 1 |
Trials
2 trials available for spermine and Sepsis
| Article | Year |
|---|---|
Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Topics: Body Weight; Caffeic Acids; Computer Simulation; Dose-Response Relationship, Drug; Humans; Models, B | 2022 |
Safety, tolerability, pharmacokinetics, and efficacy of kukoamine B in patients with sepsis: A randomized phase IIa trial.
Topics: Caffeic Acids; Double-Blind Method; Humans; Sepsis; Spermine; Treatment Outcome; Vasoconstrictor Age | 2023 |
Other Studies
12 other studies available for spermine and Sepsis
| Article | Year |
|---|---|
Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines.
Topics: Amides; Animals; Cell Line; Cell Survival; Escherichia coli; Female; Hemolysis; Humans; In Vitro Tec | 2005 |
Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models.
Topics: Animals; Biocompatible Materials; Immunity, Innate; Inflammation; Ketoglutaric Acids; Mice; Phenotyp | 2023 |
[Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis].
Topics: Animals; Caffeic Acids; Disease Models, Animal; Interleukin-1beta; Lung; Male; Mice; Mice, Inbred IC | 2014 |
[Inhibitory effects of Kukoamine B on the inflammatory response of small intestine in lipopolysaccharide-induced septic mice and its potential mechanisms].
Topics: Animals; Caffeic Acids; Cytokines; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interl | 2015 |
Structure-activity relationships of lipopolysaccharide sequestration in N-alkylpolyamines.
Topics: Cell Line; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Endotoxins; Humans; Lipop | 2009 |
Development of small-molecule endotoxin sequestering agents.
Topics: Animals; Anti-Inflammatory Agents; Carbohydrate Conformation; Clinical Trials as Topic; Endotoxins; | 2010 |
Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii.
Topics: Animals; Biosensing Techniques; Caffeic Acids; Cell Line; CpG Islands; DNA, Bacterial; Drug Discover | 2011 |
Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment.
Topics: Animals; Caffeic Acids; CpG Islands; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Escher | 2011 |
Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants.
Topics: Amides; Animals; Anti-Bacterial Agents; Binding, Competitive; Cell Line; Cytokines; Disease Models, | 2005 |
Inducible NO synthase (iNOS) in human neutrophils but not pulmonary microvascular endothelial cells (PMVEC) mediates septic protein leak in vitro.
Topics: Albumins; Cell Survival; Cells, Cultured; Endothelium, Vascular; Free Radical Scavengers; Humans; Lu | 2007 |
Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Endotoxins; Intestinal Mucosa; Jejunum; Male; Ornithine D | 1996 |
Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria.
Topics: Animals; Cytokines; Fatty Acids, Monounsaturated; Female; Glycine; Gram-Negative Bacteria; Lipopolys | 1999 |