Page last updated: 2024-08-21

quinazolines and Malaria

quinazolines has been researched along with Malaria in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (60.56)	18.7374
1990's	5 (7.04)	18.2507
2000's	12 (16.90)	29.6817
2010's	8 (11.27)	24.3611
2020's	3 (4.23)	2.80

Authors

Authors	Studies
Ashton, TD; Avery, VM; Boddey, JA; Bullen, HE; Cowman, AF; Duffy, S; Favuzza, P; Gancheva, MR; Gilson, PR; Lowes, KN; Ngo, A; Nguyen, N; Parkyn Schneider, M; Romeo, O; Sabroux, HJ; Sleebs, BE; Steel, RWJ; Wilson, DW	1
Arimondo, PB; Bozdech, Z; Claës, A; Dobrescu, I; Dziekan, JM; Halby, L; Hammam, E; Nardella, F; Preiser, P; Scherf, A	1
Abed, SN; Akrawi, SH; Aldhubiab, BE; Alwassil, OI; Attimarad, M; Bataineh, YA; Bhandary, S; Chandrashekharappa, S; Chopra, D; Deb, PK; Girish, MB; Gleiser, RM; Haroun, M; Khalil, HE; Mohanlall, V; Morsy, MA; Nair, AB; Palenge, R; Pottathil, S; Ramachandra, P; Sreeharsha, N; Tratrat, C; Venugopala, KN; Venugopala, R	1
Clardy, J; Clark, JA; Connelly, MC; Derbyshire, ER; Guiguemde, WA; Guy, RK; Magalhães, AD; Min, J	1
Huang, F; Jiang, H; Wang, Y; Xu, W; Zhang, J; Zhang, S	1
Angulo-Barturen, I; Avery, VM; Caron, J; Chen, P; Delves, MJ; Duffy, S; Ferrer, S; Fuchter, MJ; Gamo, FJ; Jiménez-Díaz, MB; Malmquist, NA; Menard, D; Nosten, F; Renia, L; Ruecker, A; Santos Martínez, M; Sanz, LM; Scherf, A; Sinden, RE; Sundriyal, S; Suwanarusk, R; Witkowski, B; Wittlin, S	1
Aguilar-Suárez, R; Correa-Basurto, J; Galindo-Sevilla, N; Hernández-Luis, F; Márquez-Navarro, A; Mendoza-Martínez, C; Montero-Cortes, MD; Nieto-Meneses, R; Nogueda-Torres, B; Rodriguez-Lezama, A; Rojas-Rojas, Á; Suárez-Contreras, E	1
Blackman, MJ; Borysov, OV; Domraceva, I; Jaudzems, K; Jirgensons, A; Kanepe-Lapsa, I; Leitans, J; Otikovs, M; Pantelejevs, T; Rasina, D; Recacha, R; Tars, K	1
Batra, S; Madapa, S; Mishra, A; Pandey, SK; Puri, SK; Srivastava, K; Tripathi, R; Tusi, Z	1
Ishih, A; Kobayashi, F; Miyase, T; Muregi, FW; Nagata, T; Ohori, K	1
Gudise, C; Smith, E; Wei, L; Zeng, Y; Zhang, Q; Zhu, S	1
Batra, S; Mishra, A; Puri, SK; Srivastava, K; Tripathi, R	1
ELDERFIELD, RC; WILLIAMSON, TA	1
Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B	1
ALDEN, BW; ENDICOTT, MM; SHERRILL, ML	1
Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S	1
Fuchter, MJ; Malmquist, NA; Mecheri, S; Moss, TA; Scherf, A	1
Deng, S; Hu, Y	1
Ishih, A; Miyase, T; Ohori, K; Terada, M	1
BASU, PC; DHATT, MS; SINGH, H	1
Ishih, A; Miyase, T; Suzuki, T; Terada, M; Watanabe, M	1
Ishih, A; Kobayashi, F; Miyase, T; Nagata, T; Terada, M	1
COATNEY, GR; COOPER, WC; CULWELL, WB; IMBODEN, CA; WHITE, WC	1
Ager, A; Gerena, L; Guan, J; Lin, AJ; O'Neil, M; Obaldia, N; Zhang, Q	1
Li, Q; Lin, AJ; Skillman, DS; Smith, K; Xie, LH; Zhang, J	1
Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K	1
Elsohly, MA; Gul, W	1
Cheng, CC; Roth, B	1
Chen, GD; Chen, L; Dai, ZR; Gong, JZ; Li, GY; Li, YT; Shen, DF; Xin, ZM; Zhang, XP	1
Li, FL; Shen, JH; Wang, QD; Wang, YL; Yao, WL; Zhang, HB; Zhang, ML	1
Chen, L; Dai, ZR; Gong, JZ; Li, GY; Xin, ZM; Zhang, XP	1
Zheng, KQ	1
Chen, L; Dai, ZR; Ma, ZM; Ni, ZG; Shen, DF; Zheng, KQ	1
Davidson, DE; Kinnamon, KE	1
Chen, L; Dai, ZR; Li, GY; Zhang, XP	1
Chen, L; Dai, ZR; Li, GY; Qian, YL; Zhang, XP	1
Chen, L; Dai, ZR; Shen, DF; Shu, KQ; Zhang, XJ; Zhang, XP	1
Chen, XH; Dai, ZR; Liu, JQ; Meng, XY; Yu, AZ; Zhang, XP	1
Chen, XH; Hu, YM; Ke, JX; Liao, YQ; Zhang, WJ	1
Chiba, T; Kim, HS; Miura, M; Oshima, Y; Takaya, Y; Takeshita, M; Tanitsu, M; Tasaka, H; Uwai, K; Wataya, Y	1
Fushiya, S; Murata, K; Oshima, Y; Takano, F	1
Hatakeyama, S; Hirai, S; Iwabuchi, Y; Kikuchi, H; Kim, HS; Ooi, H; Oshima, Y; Takaya, Y; Tasaka, H; Wataya, Y	1
Davoll, J; Elslager, EF; Jacob, P; Johnson, AM; Johnson, J; Werbel, LM	1
Schmidt, LH	3
Elslager, EF; Jacob, P; Johnson, J; Rane, L; Werbel, LM; Worth, DF	1
Rossan, RN; Schmidt, LH	1
Elslager, EF; Hutt, MP; Jacob, P; Johnson, J; Rane, L; Temporelli, B; Werbel, LM; Worth, DF	1
Ager, AL; Kinnamon, KE; Orchard, RW	1
Anderson, LC; McCormick, GJ; Willet, GP; Wise, DL	1
Buck, JM; D'Souza, L; Freisheim, JH; Hynes, JB	1
Ashton, WT; Hynes, JB	2
Chen, GD; Dai, ZR; Li, BS; Li, GY; Xin, ZM; Zhang, XP; Zhou, WC	1
Chen, L; Dai, ZR; Fu, DD; Guo, FC; Liao, ZH; Ma, DQ; Ma, ZM; Pang, XJ; Qian, YL	1
Deng, BZ; Hu, YM; Kuang, MS; Liu, FA; Wang, XX; Zhu, QP	1
Chen, L; Dai, ZR; Li, CJ; Qian, YL	1
McCormack, JJ; Richter, WE	1
Cruickshank, PA; Hymans, WE	1
Ashton, WT; Hynes, JB; Merriman, HG; Walker, FC	1
Huang, PC; Modest, EJ; Papathanasopoulos, N; Rosowsky, A	1
Canfield, CJ; Rozman, RS	1
Elslager, EF	1
Clarke, J; Davoll, J; Elslager, EF; Werbel, LM; Worth, DF	1
Bird, OD; Clarke, J; Davies, HJ; Davoll, J; Elslager, EF; Johnson, AM	1
Ashton, WT; Gratz, RF; Hynes, JB	1
Bird, OD; Clarke, J; Elslager, EF; Perricone, SC; Worth, DF	1
Burchall, JJ	1
Bayles, A; Olszewski, B; Thompson, PE	1
Modest, EJ; Rosowsky, A	1

Reviews

4 review(s) available for quinazolines and Malaria

Article	Year
Recent patent reviews on small molecule-based antimalarial drugs. Recent patents on anti-infective drug discovery, 2007, Volume: 2, Issue:3 Topics: Aminoquinolines; Animals; Antigens, Protozoan; Antimalarials; Artemisinins; Biological Assay; Flavonoids; Hepatocyte Growth Factor; Humans; Malaria; Malaria Vaccines; Patents as Topic; Plant Extracts; Primaquine; Protease Inhibitors; Quinazolines; Triazines	2007
Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines. Progress in medicinal chemistry, 1982, Volume: 19 Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines	1982
New perspectives on the chemotherapy of malaria, filariasis, and leprosy. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1974, Volume: 18 Topics: Amodiaquine; Aniline Compounds; Antimalarials; Chloroquine; Cresols; Dapsone; Drug Resistance; Filariasis; Folic Acid Antagonists; Guanidines; Humans; Leprosy; Malaria; Phenethylamines; Plasmodium falciparum; Pyrrolidines; Quinazolines; Quinolines; Schiff Bases; Sulfones	1974
Synthesis and biological activity of tricyclic antifolate compounds with fixed geometry. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Humans; Leukemia L1210; Liver; Malaria; Mammary Neoplasms, Experimental; Mice; Mouth Neoplasms; Pyrimethamine; Quinazolines; Structure-Activity Relationship	1971

Trials

2 trial(s) available for quinazolines and Malaria

Article	Year
[Observation on the efficacy of combined use of some new antimalarials for the treatment of falciparum malaria in Hainan Province]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1989, Volume: 7, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Drug Therapy, Combination; Female; Humans; Malaria; Male; Naphthyridines; Plasmodium falciparum; Quinazolines; Quinolines	1989
Clinical testing of new antimalarial compounds. Bulletin of the World Health Organization, 1974, Volume: 50, Issue:3-4 Topics: Amino Acids; Antimalarials; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Guanidines; Humans; Malaria; Naphthoquinones; Phenanthrenes; Plasmodium falciparum; Pteridines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines; Xylenes	1974

Article

Year

[Observation on the efficacy of combined use of some new antimalarials for the treatment of falciparum malaria in Hainan Province].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1989, Volume: 7, Issue:2

Topics: Adolescent; Adult; Animals; Antimalarials; Drug Therapy, Combination; Female; Humans; Malaria; Male; Naphthyridines; Plasmodium falciparum; Quinazolines; Quinolines

1989

Clinical testing of new antimalarial compounds.

Bulletin of the World Health Organization, 1974, Volume: 50, Issue:3-4

Topics: Amino Acids; Antimalarials; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Guanidines; Humans; Malaria; Naphthoquinones; Phenanthrenes; Plasmodium falciparum; Pteridines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines; Xylenes

1974

Other Studies

65 other study(ies) available for quinazolines and Malaria

Article	Year
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity. Bioorganic chemistry, 2021, Volume: 117 Topics: Amination; Aniline Compounds; Animals; Antimalarials; Female; Humans; Malaria; Mice; Plasmodium; Plasmodium falciparum; Quinazolines	2021
ACS infectious diseases, 2023, 06-09, Volume: 9, Issue:6 Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Malaria; Malaria, Falciparum; Plasmodium falciparum; Prokaryotic Initiation Factor-3; Quinazolines; Quinolines	2023
Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Molecules (Basel, Switzerland), 2020, Mar-13, Volume: 25, Issue:6 Topics: Animals; Anopheles; Computer Simulation; Crystallography, X-Ray; Insecticides; Larva; Malaria; Models, Molecular; Molecular Conformation; Mosquito Vectors; Quinazolines; Stereoisomerism	2020
Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3 Topics: Antimalarials; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	2014
Modulation of Anopheles stephensi gene expression by nitroquine, an antimalarial drug against Plasmodium yoelii infection in the mosquito. PloS one, 2014, Volume: 9, Issue:2 Topics: Animals; Anopheles; Antimalarials; Culicidae; Female; Insect Vectors; Malaria; Plasmodium yoelii; Quinazolines; Transcriptome	2014
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:2 Topics: Animals; Antimalarials; Azepines; Female; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Malaria; Malaria, Falciparum; Mice; Mice, SCID; Plasmodium berghei; Plasmodium falciparum; Quinazolines	2015
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents. European journal of medicinal chemistry, 2015, Volume: 96 Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Leishmania major; Malaria; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium vivax; Quinazolines; Structure-Activity Relationship; Trypanosoma cruzi; Vero Cells	2015
Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. Journal of medicinal chemistry, 2016, Jan-14, Volume: 59, Issue:1 Topics: 3T3 Cells; Animals; Antimalarials; Aspartic Acid Endopeptidases; Cell Survival; Crystallography, X-Ray; Malaria; Mice; Models, Molecular; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	2016
Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines. Bioorganic & medicinal chemistry, 2009, Jan-01, Volume: 17, Issue:1 Topics: Animals; Antimalarials; Inhibitory Concentration 50; Malaria; Plasmodium falciparum; Plasmodium yoelii; Quinazolines; Rats; Structure-Activity Relationship	2009
Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment. The Southeast Asian journal of tropical medicine and public health, 2008, Volume: 39, Issue:6 Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Interferon-gamma; Interleukin-4; Malaria; Male; Mice; Mice, Inbred BALB C; Parasitemia; Piperidines; Plasmodium berghei; Quinazolines	2008
Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents. Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13 Topics: Animals; Antimalarials; Drug Evaluation, Preclinical; Hydrangeaceae; Malaria; Mice; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	2009
Search for new pharmacophores for antimalarial activity. Part III: synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Animals; Antimalarials; Cell Survival; Chlorocebus aethiops; Female; Malaria; Male; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium yoelii; Quinazolines; Structure-Activity Relationship; Thiourea; Vero Cells	2009
Synthesis of bz-substituted quinazolines and antimalarials from them; a contribution to the chemistry of quinazoline. The Journal of organic chemistry, 1947, Volume: 12, Issue:3 Topics: Antimalarials; Humans; Malaria; Quinazolines	1947
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6 Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase	2010
Quinazoline derivatives; the synthesis of 4-(3'-diethylaminopropoxy)-6-chloroquinazoline (SN 12,254). Journal of the American Chemical Society, 1946, Volume: 68 Topics: Malaria; Quinazolines	1946
Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasmodium falciparum; Quinazolines	2012
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America, 2012, Oct-09, Volume: 109, Issue:41 Topics: Amino Acid Sequence; Animals; Antimalarials; Azepines; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Life Cycle Stages; Lysine; Malaria; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Sequence Homology, Amino Acid	2012
[Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1999, Volume: 17, Issue:5 Topics: Animals; Anopheles; Antimalarials; Cellular Structures; Ethanolamines; Malaria; Membranes; Parasitic Sensitivity Tests; Phospholipids; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Pyrimethamine; Quinazolines	1999
Different responses of three rodent Plasmodia species, Plasmodium yoelii 17XL, P. berghei NK65 and P. chabaudi AS on treatment with febrifugine and isofebrifugine mixture from Hydrangea macrophylla var. Otaksa leaf in ICR mice. Phytotherapy research : PTR, 2003, Volume: 17, Issue:6 Topics: Administration, Oral; Animals; Antimalarials; Hydrangea; Malaria; Male; Mice; Mice, Inbred ICR; Parasitic Sensitivity Tests; Phytotherapy; Piperidines; Plant Extracts; Plant Leaves; Plasmodium; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Quinazolines	2003
SCREENING OF POTENTIAL ANTIMALARIALS AGAINST P. GALLINACEUM IN CHICKS. IX. SOME DERIVATIVES OF 4-AMINOQUINAZOLINE, 4 (3)-QUINAZOLONE,4-AMINO-BENZ (H) QUINALDINE, BIGUANIDES AND CERTAIN INDIGENOUS DRUGS. Indian journal of physiology and pharmacology, 1964, Volume: 8 Topics: Animals; Antimalarials; Biguanides; Chickens; Guanidines; Heterocyclic Compounds; India; Malaria; Malaria, Avian; Pharmacology; Plasmodium; Poultry; Quinaldines; Quinazolines; Quinolines; Research; Toxicology	1964
Combination effects of chloroquine with the febrifugine and isofebrifugine mixture against a blood-induced infection with chloroquine-resistant Plasmodium berghei NK65 in ICR mice. Phytotherapy research : PTR, 2003, Volume: 17, Issue:10 Topics: Animals; Antimalarials; Chloroquine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Malaria; Male; Mice; Mice, Inbred ICR; Parasitic Sensitivity Tests; Phytotherapy; Piperidines; Plasmodium berghei; Quinazolines	2003
Cytokine and antibody production during the course of resolution in Plasmodium yoelii 17XL-infected BALB/c mice treated with febrifugine and isofebrifugine mixture from leaves of Hydrangea macrophylla var. Otaksa. Parasitology research, 2004, Volume: 94, Issue:3 Topics: Animals; Antibodies, Protozoan; Cytokines; Female; Hydrangea; Malaria; Mice; Mice, Inbred BALB C; Phytotherapy; Piperidines; Plant Leaves; Plasmodium yoelii; Quinazolines	2004
Studies in human malaria. XXV. Trial of febrifugine, an alkaloid obtained from Dichroa febrifuga lour., against the Chesson strain of Plasmodium vivax. Journal. National Malaria Society (U.S.), 1950, Volume: 9, Issue:2 Topics: Alkaloids; Malaria; Piperidines; Plants; Plasmodium vivax; Quinazolines	1950
Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:12 Topics: Animals; Antimalarials; Disease Models, Animal; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Pyrroles; Quinazolines	2005
New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Malaria; Maximum Tolerated Dose; Parasitemia; Plasmodium berghei; Prodrugs; Pyrroles; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Therapeutic Equivalency	2006
Exploration of a new type of antimalarial compounds based on febrifugine. Journal of medicinal chemistry, 2006, Jul-27, Volume: 49, Issue:15 Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Parasitic Sensitivity Tests; Piperidines; Plasmodium berghei; Plasmodium falciparum; Pyrimidinones; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Toxicity Tests, Acute	2006
[Antimalarial activities of 2,4-diamino-6-[(4-chlorobenzyl)-N-methyl-amino] quinazoline and its salts]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1982, Volume: 3, Issue:3 Topics: Animals; Antimalarials; Malaria; Mice; Quinazolines	1982
[Studies on antimalarials. VII. Synthesis of alpha-(alkylaminomethyl)-2-phenyl-4-quinazoline-methanols]. Yao xue xue bao = Acta pharmaceutica Sinica, 1984, Volume: 19, Issue:1 Topics: Animals; Antimalarials; Malaria; Mice; Quinazolines	1984
[Studies on antimalarials. XI. Synthesis and antimalarial activities of some 2,4-diamino-6-(N-substituted-p-chlorobenzylamino)quinazoline derivatives]. Yao xue xue bao = Acta pharmaceutica Sinica, 1984, Volume: 19, Issue:2 Topics: Animals; Antimalarials; Macaca mulatta; Malaria; Mice; Quinazolines	1984
[Studies on antimalarials. IX. Synthesis and antimalarial activity of 2,4-diamino-6-(N-(substituted benzyl)-N-(substituted aminomethyl)-amino) quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1983, Volume: 18, Issue:5 Topics: Animals; Antimalarials; Malaria; Mice; Quinazolines	1983
[Studies on antimalarials. X. Synthesis and antimalarial activity of derivatives of 2,4-diamino-6-N1,N2-disubstituted hydrazinoquinazoline]. Yao xue xue bao = Acta pharmaceutica Sinica, 1983, Volume: 18, Issue:9 Topics: Animals; Antimalarials; Malaria; Mice; Quinazolines	1983
Plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys. Experimental parasitology, 1980, Volume: 49, Issue:2 Topics: Animals; Drug Synergism; Drug Therapy, Combination; Haplorhini; Macaca mulatta; Malaria; Male; Monkey Diseases; Quinazolines	1980
[Studies on antimalarials. VII. Synthesis and antimalarial activities of some derivatives of 2, 4-dipiperidino- or 2, 4-dipyrrolidino- 6-(substituted) amino-quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1982, Volume: 17, Issue:11 Topics: Animals; Antimalarials; Malaria; Mice; Piperidines; Pyrrolidines; Quinazolines	1982
[Studies on antimalarials. III. Synthesis and antimalarial activities of some derivatives of 2,4-diamino-6-substituted piperazinyl quinazolines (author's transl)]. Yao xue xue bao = Acta pharmaceutica Sinica, 1981, Volume: 16, Issue:6 Topics: Animals; Antimalarials; Humans; Malaria; Mice; Middle Aged; Piperazines; Quinazolines	1981
[Studies on antimalarials. VI. Synthesis and antimalarial activities of some 2, 4-diamino-6-substituted amino sulfonyl quinazoline derivatives (author's transl)]. Yao xue xue bao = Acta pharmaceutica Sinica, 1981, Volume: 16, Issue:11 Topics: Animals; Antimalarials; Malaria; Mice; Quinazolines; Sulfonamides	1981
[Synthesis and biological activities of 2,4-diamino-5-fluoro-6-substituted benzylamino quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1994, Volume: 29, Issue:4 Topics: Animals; Antimalarials; Antineoplastic Agents; Leukemia L1210; Malaria; Mice; Plasmodium berghei; Quinazolines; Tumor Cells, Cultured	1994
Effects of nitroquine on ultrastructures and cytochrome oxidase of exoerythrocytic Plasmodium yoelii in rat liver. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:4 Topics: Animals; Antimalarials; Electron Transport Complex IV; Liver; Malaria; Microscopy, Electron; Plasmodium yoelii; Quinazolines; Rats; Rats, Wistar	1998
New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite. Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16 Topics: Animals; Antimalarials; Drugs, Chinese Herbal; Malaria; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Conformation; Piperidines; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Quinazolinones; Quinolizines	1999
Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Biochemical pharmacology, 1999, Nov-15, Volume: 58, Issue:10 Topics: Animals; Antimalarials; Drug Interactions; Enzyme Inhibitors; Malaria; Male; Mice; Mice, Inbred ICR; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Parasitemia; Piperidines; Plasmodium berghei; Quinazolines	1999
Potent antimalarial febrifugine analogues against the plasmodium malaria parasite. Journal of medicinal chemistry, 2002, Jun-06, Volume: 45, Issue:12 Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Piperidines; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	2002
Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. Journal of medicinal chemistry, 1978, Volume: 21, Issue:7 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Enterococcus faecalis; Folic Acid Antagonists; Malaria; Mice; Microbial Sensitivity Tests; Plasmodium berghei; Quinazolines; Staphylococcus aureus	1978
Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). III. Methods employed in the search for new blood schizonticidal drugs. The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:4 Topics: Animals; Antimalarials; Aotus trivirgatus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Female; Guanidines; Haplorhini; Hydroxamic Acids; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Pyridines; Pyrimidines; Quinazolines; Quinolines; Sulfones; Triazines	1978
Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. Journal of medicinal chemistry, 1978, Volume: 21, Issue:10 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Aotus trivirgatus; Bacteria; Chickens; Folic Acid Antagonists; Haplorhini; Malaria; Male; Mice; Microbial Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Structure-Activity Relationship	1978
Studies on the 2,4-diamino-6 substituted quinazolines. I. Antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (CI-679) as exhibited in rhesus monkeys infected with the Ro or Ro/PM strains of Plasmodium cynomolgi. The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:5 Topics: Animals; Anopheles; Drug Resistance, Microbial; Female; Haplorhini; Macaca mulatta; Malaria; Male; Plasmodium; Pyrimethamine; Quinazolines	1979
Studies on the 2,4-diamino-6-substituted quinazolines. II. Activities of selected derivatives against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmodium vivax in owl monkeys. The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:5 Topics: Animals; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance, Microbial; Female; Haplorhini; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinazolines	1979
Studies on the 2,4-diamino-6-substituted quinazolines. III. The capacity of sulfadiazine to enhance the activities of WR-158,122 and WR-159,412 against infections with various drug-susceptible and drug-resistant strains of Plasmodium falciparum and Plasmo The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:5 Topics: Animals; Aotus trivirgatus; Drug Combinations; Drug Resistance, Microbial; Female; Haplorhini; Malaria; Male; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinazolines; Sulfadiazine	1979
Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. Journal of medicinal chemistry, 1979, Volume: 22, Issue:10 Topics: Animals; Antimalarials; Bacteria; Chemical Phenomena; Chemistry; Chickens; Drug Resistance; Folic Acid Antagonists; Haplorhini; Malaria; Mice; Plasmodium; Quinazolines	1979
Plasmodium berghei: combining folic acid antagonists for potentiation against malaria infections in mice. Experimental parasitology, 1976, Volume: 40, Issue:1 Topics: Aminobenzoates; Animals; Antimalarials; Blood; Drug Combinations; Drug Synergism; Female; Folic Acid Antagonists; Malaria; Mice; Naphthalenesulfonates; Plasmodium berghei; Quinazolines; Sulfadiazine	1976
Sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid. Life sciences, 1976, Sep-15, Volume: 19, Issue:6 Topics: Animals; Antimalarials; Drug Implants; Glycolates; Lactates; Malaria; Mice; Plasmodium berghei; Polymers; Quinazolines	1976
Quinazolines as inhibitors of dihydrofolate reductase. 3. Analogs of pteroic and isopteroic acids. Journal of medicinal chemistry, 1975, Volume: 18, Issue:12 Topics: Animals; Enterococcus faecalis; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Malaria; Mice; Plasmodium berghei; Pterins; Quinazolines; Rats	1975
Synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists. Journal of medicinal chemistry, 1975, Volume: 18, Issue:3 Topics: Animals; Antimalarials; Chickens; Diamines; Folic Acid Antagonists; Liver; Malaria; Mice; Plasmodium berghei; Quinazolines; Rats	1975
[Synthesis and antimalarial as well as antitumor activities of 2,4-diamino-6-(N-methyl-substituted benzylamino) quinazolines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:2 Topics: Animals; Antimalarials; Antineoplastic Agents; Leukemia L1210; Malaria; Mice; Plasmodium berghei; Quinazolines	1989
[Action of nitroquine on tissue schizonts of Plasmodium cynomolgi]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:1 Topics: Animals; Antimalarials; Dapsone; Female; Macaca mulatta; Malaria; Male; Plasmodium; Quinazolines; Recurrence	1986
[Suppressive effect of 3 combinations of antimalarials against Plasmodium cynomolgi]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1987, Volume: 5, Issue:4 Topics: Animals; Antimalarials; Drug Therapy, Combination; Macaca mulatta; Malaria; Naphthyridines; Quinazolines; Quinolines	1987
Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds. Journal of medicinal chemistry, 1974, Volume: 17, Issue:9 Topics: Animals; Chagas Disease; Diamines; Enterococcus faecalis; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Malaria; Mice; Plasmodium berghei; Quinazolines; Rats; Trypanosoma cruzi	1974
Synthesis of 5-substituted quinazolines as potential antimalarial agents. Journal of medicinal chemistry, 1973, Volume: 16, Issue:11 Topics: Animals; Antimalarials; Folic Acid Antagonists; Liver; Malaria; Mice; Plasmodium berghei; Pyrimethamine; Quinazolines; Rats; Structure-Activity Relationship; Sulfides	1973
Antimalarials. 2. Alpha-di-n-butylaminomethyl-2-(p-chlorophenyl)-5-quinazolinemethanol. Journal of medicinal chemistry, 1974, Volume: 17, Issue:4 Topics: Animals; Antimalarials; Butylamines; Chickens; Chlorobenzenes; Malaria; Methanol; Methods; Mice; Plasmodium; Plasmodium berghei; Quinazolines	1974
Synthesis of analogs of 6-arylthio-, 6-arylsulfinyl-, and 6-arylsulfonyl-2, 4-diaminoquinazolines as potential antimalarial agents. Journal of medicinal chemistry, 1974, Volume: 17, Issue:7 Topics: Animals; Antimalarials; Drug Resistance, Microbial; Malaria; Mice; Plasmodium berghei; Quinazolines; Sulfides; Sulfinic Acids; Sulfones	1974
Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents. Journal of medicinal chemistry, 1974, Volume: 17, Issue:11 Topics: Animals; Antimalarials; Carcinoma; Cell Line; Folic Acid Antagonists; Humans; Lactobacillus; Malaria; Mice; Mouth Neoplasms; Pediococcus; Plasmodium berghei; Quinazolines; Streptococcus; Structure-Activity Relationship	1974
Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity. Journal of medicinal chemistry, 1972, Volume: 15, Issue:8 Topics: Amines; Animals; Anti-Infective Agents; Antimalarials; Antimetabolites; Chagas Disease; Chick Embryo; Chickens; Folic Acid Antagonists; Heterocyclic Compounds; Malaria; Mice; Microbial Sensitivity Tests; Quinazolines; Structure-Activity Relationship	1972
Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease. Journal of medicinal chemistry, 1972, Volume: 15, Issue:8 Topics: Animals; Antimetabolites; Benzyl Compounds; Chagas Disease; Drug Resistance, Microbial; Folic Acid Antagonists; Haplorhini; Heterocyclic Compounds; Macaca; Malaria; Methylamines; Mice; Microbial Sensitivity Tests; Quinazolines; Schiff Bases; Structure-Activity Relationship	1972
Synthesis of some bis(2,4-diaminopyrimidines) and bis(2,4-diaminoquinazolines) as potential antimalarial agents. Journal of medicinal chemistry, 1972, Volume: 15, Issue:12 Topics: Amines; Animals; Antimalarials; Columbidae; Depression, Chemical; Enterococcus faecalis; Folic Acid Antagonists; Liver; Malaria; Mice; Plasmodium berghei; Pyrimidines; Quinazolines	1972
Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects. Journal of medicinal chemistry, 1972, Volume: 15, Issue:11 Topics: Animals; Antimalarials; Antimetabolites; Chagas Disease; Chick Embryo; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Haplorhini; Lactobacillus; Lethal Dose 50; Macaca; Malaria; Mice; Microbial Sensitivity Tests; Plasmodium berghei; Quinazolines; Structure-Activity Relationship	1972
Comparative biochemistry of dihydrofolate reductase. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Animals; Anura; Biochemical Phenomena; Biochemistry; Escherichia coli; Fishes; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Malaria; Methotrexate; Nephropidae; Proteus vulgaris; Pyridines; Pyrimidines; Quinazolines; Rana pipiens; Rats; Staphylococcus; Taenia; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Turtles	1971
PAM 1392 (2,4-diamino-6-(3,4-dichlorobenzylamino) quinazoline) as a chemotherapeutic agent: Plasmodium berghei, P. cynomolgi, P. Experimental parasitology, 1969, Volume: 25, Issue:1 Topics: Animals; Antimalarials; Chagas Disease; Chick Embryo; Diet; Drug Synergism; Female; Haplorhini; Leucovorin; Malaria; Male; Mice; Plasmodium malariae; Quinazolines; Sulfadiazine; Trypanosoma	1969