prazosin has been researched along with Sepsis in 5 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was performed to assess the effects of subacute sepsis in rats on the in vitro reactivity of arterioles (internal diameter, 100-150 microm) to alpha1- and alpha2-adrenergic stimulation and to angiotensin II." | 3.70 | Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis. ( Cameron, EM; Fink, MP; Sellke, FW; Wang, SY, 1998) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.30 | Transcriptional regulation of alpha1-adrenoceptor gene in the rat liver during different phases of sepsis. ( Dong, LW; Liu, MS; Tang, C; Tong, LJ; Yang, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X | 1 |
| Zhao, C | 1 |
| Li, X | 2 |
| Wang, T | 1 |
| Li, Y | 1 |
| Cao, C | 1 |
| Ding, Y | 1 |
| Dong, M | 1 |
| Finci, L | 1 |
| Wang, JH | 1 |
| Liu, L | 1 |
| Chopra, M | 1 |
| Sharma, AC | 1 |
| Cameron, EM | 1 |
| Wang, SY | 1 |
| Fink, MP | 1 |
| Sellke, FW | 1 |
| Dong, LW | 1 |
| Yang, J | 1 |
| Tong, LJ | 1 |
| Tang, C | 1 |
| Liu, MS | 1 |
| Takakura, K | 1 |
| Taniguchi, T | 1 |
| Muramatsu, I | 1 |
| Takeuchi, K | 1 |
| Fukuda, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing Target Engagement of Terazosin in Healthy Adults[NCT04551040] | Phase 1 | 18 participants (Anticipated) | Interventional | 2021-03-26 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for prazosin and Sepsis
| Article | Year |
|---|---|
Terazosin activates Pgk1 and Hsp90 to promote stress resistance.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Cells, Cultured; Cytokines; HSP90 Heat- | 2015 |
Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart.
Topics: Adrenergic alpha-Agonists; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atenolol; Caspase 3; | 2009 |
Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis.
Topics: Angiotensin II; Animals; Blood Vessels; Disease Models, Animal; Hemodynamics; Male; Microcirculation | 1998 |
Transcriptional regulation of alpha1-adrenoceptor gene in the rat liver during different phases of sepsis.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Gene Expression Regulation; Liver; Male; Pra | 1999 |
Modification of alpha1 -adrenoceptors by peroxynitrite as a possible mechanism of systemic hypotension in sepsis.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Calcium; CHO Cells; Cricetinae; Hypotension; In Vitro | 2002 |