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pioglitazone and Benign Neoplasms, Brain

pioglitazone has been researched along with Benign Neoplasms, Brain in 14 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)."5.12Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007)
"These data indicate that pioglitazone crosses the blood-brain barrier and has antineoplastic effects in this glioma xenograft model and may be of potential use in treatment of malignant gliomas."3.79The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model. ( Blankenship, D; Caprariello, A; Dechant, A; Grommes, C; Karlo, JC; Landreth, GE, 2013)
"In this study the authors explored the benefits of treating C57B1/6 mice with an established intracerebral glioma by combining immunotherapy with interleukin (IL)-2-secreting syngeneic/allogeneic fibroblasts administered into the tumor bed along with the chemotherapeutic agent pioglitazone, a thiazolidinedione (TZD)."3.74Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts. ( Cohen, EP; Feinstein, DL; Glick, RP; Lichtor, T; Lin, H; Spagnolo, A, 2007)
"Pioglitazone was taken daily during RT and for 6 months after."2.90Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial. ( Alphonse-Sullivan, N; Blackstock, AW; Brown, DR; Chan, MD; Cramer, CK; Cummings, TL; Isom, S; Lesser, GJ; Metheny-Barlow, LJ; Page, BR; Peiffer, AM; Rapp, S; Shaw, EG; Strowd, RE, 2019)
"Glioblastoma represent the most common primary brain tumor in adults and are currently considered incurable."1.35PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. ( Heneka, MT; Hermes, M; Kummer, MP; Orlandi, M; Papi, A; Tatenhorst, L; Terwel, D, 2009)
"Furthermore, treatment of fresh glioblastoma tissue from patients with PGZ, either alone or in combination with ATRA, induced a significant level of tumor cell apoptosis together with a downregulation of bcl-2 protein level as compared with untreated control brain tissue."1.32Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. ( Black, KL; Elstner, E; Fenner, MH; Koeffler, HP; Liu, H; Posch, MG; Possinger, K; Stadelmann, C; von Deimling, A; Wächter, M; Zang, C, 2003)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's8 (57.14)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Szoka, L1
Palka, J1
Cramer, CK1
Alphonse-Sullivan, N1
Isom, S1
Metheny-Barlow, LJ1
Cummings, TL1
Page, BR1
Brown, DR1
Blackstock, AW1
Peiffer, AM1
Strowd, RE1
Rapp, S1
Lesser, GJ1
Shaw, EG1
Chan, MD1
Ren, H1
Gao, Z1
Wu, N1
Zeng, L1
Tang, X1
Chen, X1
Liu, Z1
Zhang, W1
Wang, L1
Li, Z1
Ching, J1
Amiridis, S1
Stylli, SS1
Bjorksten, AR1
Kountouri, N1
Zheng, T1
Paradiso, L1
Luwor, RB1
Morokoff, AP1
O'Brien, TJ1
Kaye, AH1
Elmaci, İ1
Altinoz, MA1
Tapia-Pérez, JH1
Preininger, R1
Kirches, E1
Reinhold, A1
Butzmann, J1
Prilloff, S1
Mawrin, C1
Schneider, T1
Papi, A1
Tatenhorst, L1
Terwel, D1
Hermes, M1
Kummer, MP1
Orlandi, M1
Heneka, MT2
Grommes, C3
Conway, DS1
Alshekhlee, A1
Barnholtz-Sloan, JS1
Yoo, JY1
Yang, SH1
Lee, JE1
Cho, DG1
Kim, HK1
Kim, SH1
Kim, IS1
Hong, JT1
Sung, JH1
Son, BC1
Lee, SW1
Karlo, JC1
Caprariello, A1
Blankenship, D1
Dechant, A1
Landreth, GE2
Zang, C1
Wächter, M1
Liu, H1
Posch, MG1
Fenner, MH1
Stadelmann, C1
von Deimling, A1
Possinger, K1
Black, KL1
Koeffler, HP1
Elstner, E1
Sastre, M1
Beck, M1
Feinstein, DL2
Jacobs, AH1
Schlegel, U1
Spagnolo, A1
Glick, RP1
Lin, H1
Cohen, EP1
Lichtor, T1
Hau, P1
Kunz-Schughart, L1
Bogdahn, U1
Baumgart, U1
Hirschmann, B1
Weimann, E1
Muhleisen, H1
Ruemmele, P1
Steinbrecher, A1
Reichle, A1

Reviews

1 review available for pioglitazone and Benign Neoplasms, Brain

ArticleYear
A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.
    Biochemical genetics, 2016, Volume: 54, Issue:5

    Topics: Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Gene Expression Regulation, Neoplast

2016

Trials

2 trials available for pioglitazone and Benign Neoplasms, Brain

ArticleYear
Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial.
    Journal of cancer research and clinical oncology, 2019, Volume: 145, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Female; Follow-Up Studies; Humans; Hypoglycemic Age

2019
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
    Oncology, 2007, Volume: 73, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin

2007

Other Studies

11 other studies available for pioglitazone and Benign Neoplasms, Brain

ArticleYear
Capsaicin up-regulates pro-apoptotic activity of thiazolidinediones in glioblastoma cell line.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 132

    Topics: Apoptosis; Brain Neoplasms; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Syne

2020
Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro.
    Biochemical and biophysical research communications, 2015, Aug-07, Volume: 463, Issue:4

    Topics: Alternative Splicing; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gli

2015
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
    Oncotarget, 2015, Aug-28, Volume: 6, Issue:25

    Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationsh

2015
Simultaneous Administration of Statins and Pioglitazone Limits Tumor Growth in a Rat Model of Malignant Glioma.
    Anticancer research, 2016, Volume: 36, Issue:12

    Topics: Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibi

2016
PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
    Journal of neurochemistry, 2009, Volume: 109, Issue:6

    Topics: Analysis of Variance; Animals; Annexin A5; Antineoplastic Agents; bcl-2-Associated X Protein; Brain

2009
Inverse association of PPARγ agonists use and high grade glioma development.
    Journal of neuro-oncology, 2010, Volume: 100, Issue:2

    Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; P

2010
E-cadherin as a predictive marker of brain metastasis in non-small-cell lung cancer, and its regulation by pioglitazone in a preclinical model.
    Journal of neuro-oncology, 2012, Volume: 109, Issue:2

    Topics: Aged; Animals; Brain; Brain Neoplasms; Cadherins; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Li

2012
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.
    Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:4

    Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioma; Humans;

2013
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas.
    Journal of neuro-oncology, 2003, Volume: 65, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Cell Cycle; Cell Divi

2003
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
    Molecular pharmacology, 2006, Volume: 70, Issue:5

    Topics: Administration, Oral; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Bromodeoxyuri

2006
Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts.
    Journal of neurosurgery, 2007, Volume: 106, Issue:2

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Sur

2007
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