pioglitazone and Benign Neoplasms, Brain
pioglitazone has been researched along with Benign Neoplasms, Brain in 14 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Research Excerpts
Excerpt | Relevance | Reference |
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"A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)." | 5.12 | Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007) |
"These data indicate that pioglitazone crosses the blood-brain barrier and has antineoplastic effects in this glioma xenograft model and may be of potential use in treatment of malignant gliomas." | 3.79 | The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model. ( Blankenship, D; Caprariello, A; Dechant, A; Grommes, C; Karlo, JC; Landreth, GE, 2013) |
"In this study the authors explored the benefits of treating C57B1/6 mice with an established intracerebral glioma by combining immunotherapy with interleukin (IL)-2-secreting syngeneic/allogeneic fibroblasts administered into the tumor bed along with the chemotherapeutic agent pioglitazone, a thiazolidinedione (TZD)." | 3.74 | Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts. ( Cohen, EP; Feinstein, DL; Glick, RP; Lichtor, T; Lin, H; Spagnolo, A, 2007) |
"Pioglitazone was taken daily during RT and for 6 months after." | 2.90 | Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial. ( Alphonse-Sullivan, N; Blackstock, AW; Brown, DR; Chan, MD; Cramer, CK; Cummings, TL; Isom, S; Lesser, GJ; Metheny-Barlow, LJ; Page, BR; Peiffer, AM; Rapp, S; Shaw, EG; Strowd, RE, 2019) |
"Glioblastoma represent the most common primary brain tumor in adults and are currently considered incurable." | 1.35 | PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. ( Heneka, MT; Hermes, M; Kummer, MP; Orlandi, M; Papi, A; Tatenhorst, L; Terwel, D, 2009) |
"Furthermore, treatment of fresh glioblastoma tissue from patients with PGZ, either alone or in combination with ATRA, induced a significant level of tumor cell apoptosis together with a downregulation of bcl-2 protein level as compared with untreated control brain tissue." | 1.32 | Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. ( Black, KL; Elstner, E; Fenner, MH; Koeffler, HP; Liu, H; Posch, MG; Possinger, K; Stadelmann, C; von Deimling, A; Wächter, M; Zang, C, 2003) |
Research
Studies (14)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (35.71) | 29.6817 |
2010's | 8 (57.14) | 24.3611 |
2020's | 1 (7.14) | 2.80 |
Authors
Authors | Studies |
---|---|
Szoka, L | 1 |
Palka, J | 1 |
Cramer, CK | 1 |
Alphonse-Sullivan, N | 1 |
Isom, S | 1 |
Metheny-Barlow, LJ | 1 |
Cummings, TL | 1 |
Page, BR | 1 |
Brown, DR | 1 |
Blackstock, AW | 1 |
Peiffer, AM | 1 |
Strowd, RE | 1 |
Rapp, S | 1 |
Lesser, GJ | 1 |
Shaw, EG | 1 |
Chan, MD | 1 |
Ren, H | 1 |
Gao, Z | 1 |
Wu, N | 1 |
Zeng, L | 1 |
Tang, X | 1 |
Chen, X | 1 |
Liu, Z | 1 |
Zhang, W | 1 |
Wang, L | 1 |
Li, Z | 1 |
Ching, J | 1 |
Amiridis, S | 1 |
Stylli, SS | 1 |
Bjorksten, AR | 1 |
Kountouri, N | 1 |
Zheng, T | 1 |
Paradiso, L | 1 |
Luwor, RB | 1 |
Morokoff, AP | 1 |
O'Brien, TJ | 1 |
Kaye, AH | 1 |
Elmaci, İ | 1 |
Altinoz, MA | 1 |
Tapia-Pérez, JH | 1 |
Preininger, R | 1 |
Kirches, E | 1 |
Reinhold, A | 1 |
Butzmann, J | 1 |
Prilloff, S | 1 |
Mawrin, C | 1 |
Schneider, T | 1 |
Papi, A | 1 |
Tatenhorst, L | 1 |
Terwel, D | 1 |
Hermes, M | 1 |
Kummer, MP | 1 |
Orlandi, M | 1 |
Heneka, MT | 2 |
Grommes, C | 3 |
Conway, DS | 1 |
Alshekhlee, A | 1 |
Barnholtz-Sloan, JS | 1 |
Yoo, JY | 1 |
Yang, SH | 1 |
Lee, JE | 1 |
Cho, DG | 1 |
Kim, HK | 1 |
Kim, SH | 1 |
Kim, IS | 1 |
Hong, JT | 1 |
Sung, JH | 1 |
Son, BC | 1 |
Lee, SW | 1 |
Karlo, JC | 1 |
Caprariello, A | 1 |
Blankenship, D | 1 |
Dechant, A | 1 |
Landreth, GE | 2 |
Zang, C | 1 |
Wächter, M | 1 |
Liu, H | 1 |
Posch, MG | 1 |
Fenner, MH | 1 |
Stadelmann, C | 1 |
von Deimling, A | 1 |
Possinger, K | 1 |
Black, KL | 1 |
Koeffler, HP | 1 |
Elstner, E | 1 |
Sastre, M | 1 |
Beck, M | 1 |
Feinstein, DL | 2 |
Jacobs, AH | 1 |
Schlegel, U | 1 |
Spagnolo, A | 1 |
Glick, RP | 1 |
Lin, H | 1 |
Cohen, EP | 1 |
Lichtor, T | 1 |
Hau, P | 1 |
Kunz-Schughart, L | 1 |
Bogdahn, U | 1 |
Baumgart, U | 1 |
Hirschmann, B | 1 |
Weimann, E | 1 |
Muhleisen, H | 1 |
Ruemmele, P | 1 |
Steinbrecher, A | 1 |
Reichle, A | 1 |
Reviews
1 review available for pioglitazone and Benign Neoplasms, Brain
Article | Year |
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A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.
Topics: Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Gene Expression Regulation, Neoplast | 2016 |
Trials
2 trials available for pioglitazone and Benign Neoplasms, Brain
Article | Year |
---|---|
Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Female; Follow-Up Studies; Humans; Hypoglycemic Age | 2019 |
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin | 2007 |
Other Studies
11 other studies available for pioglitazone and Benign Neoplasms, Brain
Article | Year |
---|---|
Capsaicin up-regulates pro-apoptotic activity of thiazolidinediones in glioblastoma cell line.
Topics: Apoptosis; Brain Neoplasms; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Syne | 2020 |
Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro.
Topics: Alternative Splicing; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gli | 2015 |
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationsh | 2015 |
Simultaneous Administration of Statins and Pioglitazone Limits Tumor Growth in a Rat Model of Malignant Glioma.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibi | 2016 |
PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
Topics: Analysis of Variance; Animals; Annexin A5; Antineoplastic Agents; bcl-2-Associated X Protein; Brain | 2009 |
Inverse association of PPARγ agonists use and high grade glioma development.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; P | 2010 |
E-cadherin as a predictive marker of brain metastasis in non-small-cell lung cancer, and its regulation by pioglitazone in a preclinical model.
Topics: Aged; Animals; Brain; Brain Neoplasms; Cadherins; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Li | 2012 |
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; | 2013 |
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Cell Cycle; Cell Divi | 2003 |
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
Topics: Administration, Oral; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Bromodeoxyuri | 2006 |
Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Sur | 2007 |