pd 98059 has been researched along with Sepsis in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The CLP-induced reduction in intrinsic HCO(3)(-) absorption rate appears to involve loss of function of basolateral Na(+)/H(+) exchange." | 1.39 | A two-hit mechanism for sepsis-induced impairment of renal tubule function. ( George, T; Good, DW; Sherwood, ER; Watts, BA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, G | 1 |
| Zhang, Y | 2 |
| Liu, X | 1 |
| Fang, Q | 1 |
| Wang, Z | 1 |
| Fu, L | 1 |
| Liu, Z | 1 |
| Wang, Y | 1 |
| Zhao, Y | 1 |
| Li, X | 1 |
| Liang, G | 1 |
| Lin, Y | 1 |
| Wongkrajang, K | 1 |
| Shen, X | 1 |
| Wang, P | 1 |
| Zhou, Z | 1 |
| Chuprajob, T | 1 |
| Sornkaew, N | 1 |
| Yang, N | 1 |
| Yang, L | 1 |
| Lu, X | 1 |
| Chokchaisiri, R | 1 |
| Suksamrarn, A | 1 |
| Zhang, G | 1 |
| Wang, F | 1 |
| Wang, X | 1 |
| Li, Y | 1 |
| Zhao, Z | 1 |
| Meng, Y | 1 |
| Bian, J | 1 |
| Bao, R | 1 |
| Zhu, K | 1 |
| Yang, T | 1 |
| Jun, MS | 1 |
| Kim, HS | 1 |
| Kim, YM | 1 |
| Kim, HJ | 1 |
| Park, EJ | 1 |
| Lee, JH | 1 |
| Lee, KR | 1 |
| Kim, YS | 1 |
| Chang, KC | 1 |
| Watts, BA | 1 |
| George, T | 1 |
| Sherwood, ER | 1 |
| Good, DW | 1 |
| Jiang, JX | 1 |
| Ji, SH | 1 |
| Zhu, P | 1 |
| Wang, ZG | 1 |
6 other studies available for pd 98059 and Sepsis
| Article | Year |
|---|---|
Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cinnamates; Cyto | 2016 |
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Diarylheptanoids; Janus Kinase 2; Lipopolysaccharides; Macrophage | 2022 |
IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling.
Topics: Actins; Acute Kidney Injury; Albumins; Animals; Antigens, CD; Biomarkers; Blood Urea Nitrogen; Cadhe | 2019 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, | 2012 |
A two-hit mechanism for sepsis-induced impairment of renal tubule function.
Topics: Absorption; Aldosterone; Amiloride; Animals; Bicarbonates; Cecum; Extracellular Signal-Regulated MAP | 2013 |
Kinetics of mitogen-activated protein kinase family in lipopolysaccharide-stimulated mouse Kupffer cells and their role in cytokine production.
Topics: Animals; Cytokines; Female; Flavonoids; Imidazoles; Inflammation; Interleukin-10; Kinetics; Kupffer | 2002 |