ondansetron has been researched along with Pain in 62 studies
Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary outcome was the efficacy of ondansetron compared to lidocaine and placebo for the reduction of propofol injection pain." | 9.51 | A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study. ( Chaofan, S; Kosem, R; Plansangkate, P; Tanasansuttiporn, J; Termthong, S; Wasinwong, W, 2022) |
| "To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups." | 9.16 | Ondansetron pretreatment reduces pain on injection of propofol. ( Maleki, A; Rostami, G; Zahedi, H, 2012) |
| "The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal hysterectomy under general anesthesia." | 9.14 | [Effect of ondansetron combined with dexamethasone on postoperative nausea & vomiting and pain of patients with laparoscopic hysterectomy]. ( Nam, M; Yoon, H, 2009) |
| "To determine the efficacy of transdermal scopolamine in addition to ondansetron in decreasing the incidence of postoperative nausea and vomiting (PONV)." | 9.14 | Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. ( Dalby, P; Kaul, B; Ramesh, V; Sah, N; Shestak, K; Vallejo, MC, 2009) |
| "Fentanyl is commonly used for spinal analgesia during labour but it is associated with a high incidence of pruritus." | 9.11 | Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron. ( Evans, SF; Paech, MJ; Wells, J, 2004) |
| "Tramadol or ondansetron are equally effective in preventing pain from propofol injection." | 9.10 | The prevention of propofol injection pain by tramadol or ondansetron. ( Karamanlioglu, B; Kaya, G; Memiş, D; Pamukçu, Z; Turan, A, 2002) |
| "We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing the pain on injection of rocuronium in 250 patients." | 9.10 | The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "We used a randomized, controlled, double-blinded design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol." | 9.09 | Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study. ( Ambesh, SP; Dubey, PK; Sinha, PK, 1999) |
| "In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups." | 9.09 | Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. ( Chen, FG; Ng, HP; Reddy, MS, 2001) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 7.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " We treated the pain of acute arthritis with the specific 5-hydroxytryptamine subtype 3 receptor antagonist ondansetron." | 7.69 | Treatment of acute gouty arthritis with the 5-hydroxytryptamine antagonist ondansetron. ( Ramadori, G; Schwörer, H, 1994) |
| "Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients." | 6.70 | A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients. ( Albertsson, M; Chimontsi-Kypriou, V; Curtis, P; Daly, S; Hardy, J; McQuade, B; Stathopoulos, P, 2002) |
| "The primary outcome was the efficacy of ondansetron compared to lidocaine and placebo for the reduction of propofol injection pain." | 5.51 | A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study. ( Chaofan, S; Kosem, R; Plansangkate, P; Tanasansuttiporn, J; Termthong, S; Wasinwong, W, 2022) |
| " No differences between the two groups were detected for postoperative consumption of tramadol, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction." | 5.51 | The Effect of Ondansetron on the Analgesic Efficacy of Tramadol in Patients Undergoing Laparoscopic Cholecystectomy. ( Bilgen, S; Erdoğan Ari, D; Özveri, E, 2022) |
| ") had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell-shaped dose-response relationship." | 5.28 | The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. ( Moss, HE; Sanger, GJ, 1990) |
| "To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups." | 5.16 | Ondansetron pretreatment reduces pain on injection of propofol. ( Maleki, A; Rostami, G; Zahedi, H, 2012) |
| "The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal hysterectomy under general anesthesia." | 5.14 | [Effect of ondansetron combined with dexamethasone on postoperative nausea & vomiting and pain of patients with laparoscopic hysterectomy]. ( Nam, M; Yoon, H, 2009) |
| "To determine the efficacy of transdermal scopolamine in addition to ondansetron in decreasing the incidence of postoperative nausea and vomiting (PONV)." | 5.14 | Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. ( Dalby, P; Kaul, B; Ramesh, V; Sah, N; Shestak, K; Vallejo, MC, 2009) |
| "This study provides evidence that the addition of an analgesic (fentanyl) and an anti-emetic (ondansetron) to the combination of a sedative (midazolam) and an anesthetic (propofol) is of measurable benefit in children who undergo procedures that are painful and risk the consequence of nausea and vomiting." | 5.13 | Pediatric oncology sedation trial (POST): A double-blind randomized study. ( Barr, RD; Buckley, N; Korz, L; Lappan, J; Nagel, K; Willan, AR, 2008) |
| "Fentanyl is commonly used for spinal analgesia during labour but it is associated with a high incidence of pruritus." | 5.11 | Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron. ( Evans, SF; Paech, MJ; Wells, J, 2004) |
| "Tramadol or ondansetron are equally effective in preventing pain from propofol injection." | 5.10 | The prevention of propofol injection pain by tramadol or ondansetron. ( Karamanlioglu, B; Kaya, G; Memiş, D; Pamukçu, Z; Turan, A, 2002) |
| "We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing the pain on injection of rocuronium in 250 patients." | 5.10 | The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups." | 5.09 | Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. ( Chen, FG; Ng, HP; Reddy, MS, 2001) |
| "We used a randomized, controlled, double-blinded design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol." | 5.09 | Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study. ( Ambesh, SP; Dubey, PK; Sinha, PK, 1999) |
| "To compare the efficacy of ondansetron-dexamethasone combination with ondansetron alone for prevention of postoperative nausea and vomiting (PONV)." | 5.09 | Comparison of ondansetron with ondansetron and dexamethasone in prevention of PONV in diagnostic laparoscopy. ( Batra, YK; Bhardwaj, N; Dhaliwal, LK; Rajeeva, V, 1999) |
| "Ondansetron reduced the incidence of postoperative emesis from 62% to 27% (relative risk 0." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "The use of ondansetron, a selective serotonin 5-HT3 receptor antagonist, is well established in patients with nausea and vomiting associated with cancer chemotherapy, radiotherapy or anaesthesia and surgery." | 4.79 | Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. ( Markham, A; Wilde, MI, 1996) |
| "This study aimed to identify if prophylactic ondansetron administered with intravenous (IV) opioids prevents opioid-induced nausea or vomiting." | 3.85 | Use of Prophylactic Ondansetron with Intravenous Opioids in Emergency Department Patients: A Prospective Observational Pilot Study. ( Culver, MA; Edwards, CJ; Jarrell, DH; Richards, EC, 2017) |
| " The following items: name of the anesthetist, duration of anesthesia, duration of monitoring, ventilatory status upon arrival in postoperative care unit, pain scores, nausea and vomiting scores, pain medication (morphine) and anti nausea and vomiting drug consumption (ondansetron) were extracted and analysed in order to determine exhaustivity (percentage of missing data) and accuracy of the database." | 3.81 | The use of a clinical database in an anesthesia unit: focus on its limits. ( Bourgain, JL; Eghiaian, A; Guye, ML; Motamed, C; Weil, G, 2015) |
| " Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord." | 3.81 | Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. ( Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H, 2015) |
| " We investigated pregabalin, indicated for neuropathic pain, and ondansetron, a drug that disrupts descending serotonergic processing in the central nervous system, on spinal neuronal hyperexcitability and visceral hypersensitivity in a rat model of opioid-induced hyperalgesia." | 3.77 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| " In uninjured rats, RVM microinjection of morphine produced dose-dependent antinociception in the noxious thermal paw flick test while RVM microinjection of CCK produced thermal hyperalgesia and tactile allodynia." | 3.75 | Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. ( Dogrul, A; Ossipov, MH; Porreca, F, 2009) |
| "The role of peripheral 5-HT3 receptors in the nociceptive behavioral response and the effect of the 5-HT3 antagonist ondansetron on indices of acute and tonic pain were investigated in the formalin test in 25- and 90-day-old Wistar male rats." | 3.74 | [Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress]. ( Butkevich, IP; Makukhina, GV; Mikhaĭlenko, VA, 2007) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 3.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " To determine if this pathway plays a role in the pathophysiology of inflammation, we investigated the effects of spinally administered ondansetron (a selective 5HT3 receptor antagonist) on deep dorsal horn neuronal responses in carrageenan inflamed and naïve animals using in vivo electrophysiology." | 3.72 | Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation. ( Dickenson, AH; Rahman, W; Rygh, LJ; Suzuki, R, 2004) |
| " We treated the pain of acute arthritis with the specific 5-hydroxytryptamine subtype 3 receptor antagonist ondansetron." | 3.69 | Treatment of acute gouty arthritis with the 5-hydroxytryptamine antagonist ondansetron. ( Ramadori, G; Schwörer, H, 1994) |
| "Pregnant women with gestational diabetes mellitus (GDM) require more analgesics after cesarean delivery than those who do not have GDM." | 3.30 | Low-dose esketamine with sufentanil for postcesarean analgesia in women with gestational diabetes mellitus: a prospective, randomized, double-blind study. ( Chen, L; Chen, Q; Han, T; Huang, J; Li, A; Li, Z; Peng, Z; Xu, W; Zhang, J, 2023) |
| "Droperidol is a butyrophenone, with antiemetic, sedative, anxiolytic, and analgesic properties." | 3.01 | Droperidol Use in the Emergency Department: A Clinical Review. ( Marcolini, EG; Motov, SM; Siegel, RB, 2023) |
| "Nausea and emesis are common side effects of opioid drugs administered for pain relief in cancer patients." | 2.70 | A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients. ( Albertsson, M; Chimontsi-Kypriou, V; Curtis, P; Daly, S; Hardy, J; McQuade, B; Stathopoulos, P, 2002) |
| "Double-blind treatment of severe bulimia nervosa subjects with ONDAN resulted in a rapid and significant decrease in binge-eating and vomiting compared to placebo controls." | 2.43 | Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms. ( Eckert, ED; Faris, PL; Goodale, RL; Hartman, BK; Kim, SW; Meller, WH; Pardo, JV, 2006) |
| "PONV was experienced by 74." | 1.91 | Prevalence, Risk Factors, and Management of Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy (a Retrospective Multicentric Study). ( Abuyousif, YA; Aldossary, HM; Attia, M; El Hefnawy, E; El Nakeeb, A; Elmorshedi, M; Mohammed, MN; Rashad, AE; Salem, A; Zaid, A, 2023) |
| "Pain in Parkinson's disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients." | 1.72 | Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022) |
| "We observed significant hindpaw allodynia in TBI rats that was reduced after DHT but not vehicle treatment." | 1.51 | Enhanced descending pain facilitation in acute traumatic brain injury. ( Clark, JD; Ferguson, AR; Irvine, KA; Sahbaie, P, 2019) |
| "Pain is one of the most prevalent, costly and disabling conditions that reduces quality of life." | 1.48 | Antinociceptive and anti-inflammatory effects of 1,2-bis-(4 methoxyphenylselanyl) styrene in mice: involvement of the serotonergic system. ( Anversa, RG; Birmann, PT; Bruning, CA; Lenardão, EJ; Lima, DB; Savegnago, L; Sousa, FSS, 2018) |
| "Snakebites are common in many regions of the United States." | 1.46 | White-Lipped Tree Viper (Cryptelytrops albolabris) Envenomation in an American Viper Keeper. ( Galdamez, LA; Greene, S; Tomasheski, R, 2017) |
| "CYP2D6 drug-drug interactions appear to change effectiveness of commonly prescribed drugs in the ED." | 1.40 | The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. ( Campbell, J; Hamamura, D; Heard, KJ; Monte, AA; Vasiliou, V; Weinshilboum, RM, 2014) |
| " Ablation of NK-1 receptor expressing cells prevented (a) morphine-induced thermal and mechanical hypersensitivity, (b) increased touch-evoked spinal FOS expression, (c) upregulation of spinal dynorphin content and (d) the rightward displacement of the spinal morphine antinociceptive dose-response curve (i." | 1.34 | Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. ( King, T; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW; Vera-Portocarrero, LP; Zhang, ET, 2007) |
| " Dose-response curves were also obtained with tramadol combined with ondansetron or droperidol at 1:1 fixed ratios." | 1.33 | Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice. ( Dürsteler, C; Fernandez, V; Mases, A; Pol, O; Puig, MM, 2006) |
| "Ondansetron is a potent antiemetic drug that acts through inhibition of the 5HT3 receptors for serotonin." | 1.33 | The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition. ( Flood, P; Scott, JA; Wood, M, 2006) |
| "Rats treated with nifedipine alone had an increase in tail-flick latency of 122%, as measured by the area under the curve, compared to rats treated with DMSO alone." | 1.29 | Ondansetron blocks nifedipine-induced analgesia in rats. ( Hunt, TE; Wu, W; Zbuzek, VK, 1996) |
| "6% acetic acid) in conscious rats with a bell-shaped dose-response curve." | 1.29 | Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model. ( Dahl, SG; Junien, JL; Langlois, A; Pascaud, X; Rivière, PJ, 1996) |
| " Chronic administration of morphine (10 mg/kg i." | 1.29 | Prevention of morphine discontinuation phenomenon in mice by ondansetron, a selective 5-HT3 antagonist. ( Kulkarni, SK; Roychoudhury, M, 1996) |
| ") had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell-shaped dose-response relationship." | 1.28 | The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. ( Moss, HE; Sanger, GJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (19.35) | 18.2507 |
| 2000's | 24 (38.71) | 29.6817 |
| 2010's | 19 (30.65) | 24.3611 |
| 2020's | 7 (11.29) | 2.80 |
| Authors | Studies |
|---|---|
| Valhondo, M | 1 |
| Marco, I | 1 |
| Martín-Fontecha, M | 1 |
| Vázquez-Villa, H | 1 |
| Ramos, JA | 1 |
| Berkels, R | 1 |
| Lauterbach, T | 1 |
| Benhamú, B | 1 |
| López-Rodríguez, ML | 1 |
| Wasinwong, W | 1 |
| Termthong, S | 1 |
| Plansangkate, P | 1 |
| Tanasansuttiporn, J | 1 |
| Kosem, R | 1 |
| Chaofan, S | 1 |
| Bilgen, S | 1 |
| Erdoğan Ari, D | 1 |
| Özveri, E | 1 |
| Li, CJ | 1 |
| Zhang, LG | 1 |
| Liu, LB | 1 |
| An, MQ | 1 |
| Dong, LG | 1 |
| Gu, HY | 1 |
| Dai, YP | 1 |
| Wang, F | 1 |
| Mao, CJ | 1 |
| Liu, CF | 1 |
| Siegel, RB | 1 |
| Motov, SM | 1 |
| Marcolini, EG | 1 |
| Rashad, AE | 1 |
| El Hefnawy, E | 1 |
| Elmorshedi, M | 1 |
| Abuyousif, YA | 1 |
| Salem, A | 1 |
| Attia, M | 1 |
| El Nakeeb, A | 1 |
| Zaid, A | 1 |
| Aldossary, HM | 1 |
| Mohammed, MN | 1 |
| Han, T | 1 |
| Chen, Q | 1 |
| Huang, J | 1 |
| Zhang, J | 1 |
| Li, A | 1 |
| Xu, W | 1 |
| Peng, Z | 1 |
| Li, Z | 1 |
| Chen, L | 1 |
| Ben-Yakov, M | 1 |
| Bhatt, M | 1 |
| Culver, MA | 1 |
| Richards, EC | 1 |
| Jarrell, DH | 1 |
| Edwards, CJ | 1 |
| Greene, S | 1 |
| Galdamez, LA | 1 |
| Tomasheski, R | 1 |
| Anversa, RG | 1 |
| Sousa, FSS | 1 |
| Birmann, PT | 1 |
| Lima, DB | 1 |
| Lenardão, EJ | 1 |
| Bruning, CA | 1 |
| Savegnago, L | 1 |
| Giorno, TBS | 2 |
| Moreira, IGDS | 1 |
| Rezende, CM | 1 |
| Fernandes, PD | 2 |
| Irvine, KA | 1 |
| Sahbaie, P | 1 |
| Ferguson, AR | 1 |
| Clark, JD | 1 |
| Weil, G | 1 |
| Motamed, C | 1 |
| Eghiaian, A | 1 |
| Guye, ML | 1 |
| Bourgain, JL | 1 |
| Monte, AA | 1 |
| Heard, KJ | 1 |
| Campbell, J | 1 |
| Hamamura, D | 1 |
| Weinshilboum, RM | 1 |
| Vasiliou, V | 1 |
| Lee, HG | 1 |
| Kim, WM | 1 |
| Kim, JM | 1 |
| Bae, HB | 2 |
| Choi, JI | 2 |
| Soga, T | 1 |
| Kume, K | 1 |
| Kakuta, N | 1 |
| Hamaguchi, E | 1 |
| Tsutsumi, R | 1 |
| Kawanishi, R | 1 |
| Fukuta, K | 1 |
| Tanaka, K | 1 |
| Tsutsumi, YM | 1 |
| Carrillo-Munguía, N | 1 |
| González-Trujano, ME | 1 |
| Huerta, M | 1 |
| Trujillo, X | 1 |
| Díaz-Reval, MI | 1 |
| Amorim, D | 1 |
| Viisanen, H | 1 |
| Wei, H | 1 |
| Almeida, A | 1 |
| Pertovaara, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Silva, BVD | 1 |
| Pinto, ADC | 1 |
| Nagel, K | 1 |
| Willan, AR | 1 |
| Lappan, J | 1 |
| Korz, L | 1 |
| Buckley, N | 1 |
| Barr, RD | 1 |
| Nam, M | 1 |
| Yoon, H | 1 |
| Dogrul, A | 1 |
| Ossipov, MH | 2 |
| Porreca, F | 3 |
| Sah, N | 1 |
| Ramesh, V | 1 |
| Kaul, B | 1 |
| Dalby, P | 1 |
| Shestak, K | 1 |
| Vallejo, MC | 1 |
| Peters, CM | 1 |
| Hayashida, K | 2 |
| Ewan, EE | 1 |
| Nakajima, K | 1 |
| Obata, H | 2 |
| Xu, Q | 1 |
| Yaksh, TL | 1 |
| Eisenach, JC | 2 |
| Bannister, K | 1 |
| Sikandar, S | 1 |
| Bauer, CS | 1 |
| Dolphin, AC | 1 |
| Dickenson, AH | 5 |
| Hales, TG | 1 |
| Norouzi, A | 1 |
| Fakhfouri, G | 1 |
| Rahimian, R | 1 |
| Zahedi, H | 1 |
| Maleki, A | 1 |
| Rostami, G | 1 |
| Kimura, M | 1 |
| Yoshizumi, M | 1 |
| Hobo, S | 1 |
| McCleane, GJ | 1 |
| Suzuki, R | 3 |
| Rahman, W | 2 |
| Rygh, LJ | 2 |
| Oatway, MA | 1 |
| Chen, Y | 1 |
| Weaver, LC | 1 |
| Wells, J | 1 |
| Paech, MJ | 1 |
| Evans, SF | 1 |
| Webber, M | 1 |
| Hunt, SP | 1 |
| Donovan-Rodriguez, T | 1 |
| Urch, CE | 1 |
| Dürsteler, C | 1 |
| Mases, A | 1 |
| Fernandez, V | 1 |
| Pol, O | 1 |
| Puig, MM | 1 |
| Dukat, M | 1 |
| Wesołowska, A | 1 |
| Faris, PL | 1 |
| Eckert, ED | 1 |
| Kim, SW | 1 |
| Meller, WH | 1 |
| Pardo, JV | 1 |
| Goodale, RL | 1 |
| Hartman, BK | 1 |
| Llanes, LR | 1 |
| Fassbender, K | 1 |
| Baracos, VE | 1 |
| Watanabe, S | 1 |
| Yoon, MH | 1 |
| Kim, SJ | 1 |
| Chung, ST | 1 |
| Kim, CM | 1 |
| Scott, JA | 1 |
| Wood, M | 1 |
| Flood, P | 1 |
| Vera-Portocarrero, LP | 1 |
| Zhang, ET | 1 |
| King, T | 1 |
| Vanderah, TW | 1 |
| Lai, J | 1 |
| Butkevich, IP | 1 |
| Mikhaĭlenko, VA | 1 |
| Makukhina, GV | 1 |
| Dizdar, V | 1 |
| Gilja, OH | 1 |
| Hausken, T | 1 |
| Cole, RM | 1 |
| Robinson, F | 1 |
| Harvey, L | 1 |
| Trethowan, K | 1 |
| Murdoch, V | 1 |
| Schwörer, H | 1 |
| Ramadori, G | 1 |
| Furst, SR | 1 |
| Rodarte, A | 1 |
| Petersen-Felix, S | 1 |
| Arendt-Nielsen, L | 1 |
| Bak, P | 1 |
| Bjerring, P | 1 |
| Breivik, H | 1 |
| Svensson, P | 1 |
| Zbinden, AM | 1 |
| Hunt, TE | 1 |
| Wu, W | 1 |
| Zbuzek, VK | 1 |
| Langlois, A | 1 |
| Pascaud, X | 1 |
| Junien, JL | 1 |
| Dahl, SG | 1 |
| Rivière, PJ | 1 |
| Wilde, MI | 1 |
| Markham, A | 1 |
| Roychoudhury, M | 1 |
| Kulkarni, SK | 1 |
| Rajeeva, V | 1 |
| Bhardwaj, N | 1 |
| Batra, YK | 1 |
| Dhaliwal, LK | 1 |
| Ambesh, SP | 1 |
| Dubey, PK | 1 |
| Sinha, PK | 1 |
| Green, MG | 1 |
| Scarth, J | 1 |
| Dickenson, A | 1 |
| Reddy, MS | 1 |
| Chen, FG | 1 |
| Ng, HP | 1 |
| Hardy, J | 1 |
| Daly, S | 1 |
| McQuade, B | 1 |
| Albertsson, M | 1 |
| Chimontsi-Kypriou, V | 1 |
| Stathopoulos, P | 1 |
| Curtis, P | 1 |
| Memiş, D | 2 |
| Turan, A | 2 |
| Karamanlioglu, B | 2 |
| Kaya, G | 1 |
| Pamukçu, Z | 2 |
| Süt, N | 1 |
| Sufka, KJ | 1 |
| Schomburg, FM | 1 |
| Giordano, J | 1 |
| Moss, HE | 1 |
| Sanger, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Ondansetron on the Efficacy of Tramadol[NCT04745273] | Phase 4 | 60 participants (Actual) | Interventional | 2020-09-02 | Completed | ||
| Effects of Pgp Transporter Inhibition on CNS Biodistribution of Ondansetron in Healthy Volunteers[NCT03809234] | Phase 1 | 14 participants (Actual) | Interventional | 2019-05-20 | Terminated (stopped due to Adverse effects related to study procedure (not study drug)) | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093] | Phase 3 | 66 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Pain Phenotyping of Patients With Bone Cancer Pain[NCT03908853] | 70 participants (Anticipated) | Observational | 2019-02-05 | Recruiting | |||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674] | 10 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (OOWS Scale) (Mean) |
|---|---|
| Placebo | 3.5 |
| Palonosetron | 1.0 |
| Palonosetron + Hydroxyzine | 0 |
"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (SOWS Scale) (Mean) |
|---|---|
| Placebo | 6.0 |
| Palonosetron | 4.0 |
| Palonosetron + Hydroxyzine | 3.5 |
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
3 reviews available for ondansetron and Pain
| Article | Year |
|---|---|
Droperidol Use in the Emergency Department: A Clinical Review.
Topics: Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Antiemetics; Droperidol; Emergency Service, Hos | 2023 |
Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms.
Topics: Bulimia Nervosa; Depression; Humans; Neurons, Afferent; Ondansetron; Pain; Pain Measurement; Seroton | 2006 |
Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications.
Topics: Animals; Antiemetics; Brain; Colonic Diseases, Functional; Digestive System; Drug Interactions; Drug | 1996 |
19 trials available for ondansetron and Pain
| Article | Year |
|---|---|
A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Humans; | 2022 |
The Effect of Ondansetron on the Analgesic Efficacy of Tramadol in Patients Undergoing Laparoscopic Cholecystectomy.
Topics: Adult; Analgesics; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Humans; Middle A | 2022 |
Low-dose esketamine with sufentanil for postcesarean analgesia in women with gestational diabetes mellitus: a prospective, randomized, double-blind study.
Topics: Analgesia; Diabetes, Gestational; Double-Blind Method; Female; Humans; Infant, Newborn; Ondansetron; | 2023 |
Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Androstanols; Antieme | 2015 |
Pediatric oncology sedation trial (POST): A double-blind randomized study.
Topics: Adolescent; Antiemetics; Antineoplastic Agents; Biopsy, Needle; Bone Marrow Examination; Child; Chil | 2008 |
[Effect of ondansetron combined with dexamethasone on postoperative nausea & vomiting and pain of patients with laparoscopic hysterectomy].
Topics: Adult; Analgesia, Patient-Controlled; Analysis of Variance; Anesthesia, General; Antiemetics; Data I | 2009 |
Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery.
Topics: Administration, Cutaneous; Adult; Ambulatory Surgical Procedures; Antiemetics; Cholinergic Antagonis | 2009 |
Ondansetron pretreatment reduces pain on injection of propofol.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; | 2012 |
Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Ondan | 2003 |
Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron.
Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Humans; In | 2004 |
Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3-antagonist ondansetron.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Giardiasis; Human | 2007 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Ondansetron does not inhibit the analgesic effect of alfentanil.
Topics: Adult; Alfentanil; Analgesia; Cold Temperature; Cross-Over Studies; Double-Blind Method; Electric St | 1994 |
Comparison of ondansetron with ondansetron and dexamethasone in prevention of PONV in diagnostic laparoscopy.
Topics: Adult; Ambulatory Care; Antiemetics; Dexamethasone; Double-Blind Method; Drug Combinations; Female; | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine.
Topics: Adult; Androstanols; Anesthetics, Intravenous; Anesthetics, Local; Antiemetics; Double-Blind Method; | 2001 |
A double-blind, randomised, parallel group, multinational, multicentre study comparing a single dose of ondansetron 24 mg p.o. with placebo and metoclopramide 10 mg t.d.s. p.o. in the treatment of opioid-induced nausea and emesis in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans | 2002 |
The prevention of propofol injection pain by tramadol or ondansetron.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Male; Onda | 2002 |
The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl.
Topics: Adult; Analgesics, Opioid; Androstanols; Anesthetics, Local; Double-Blind Method; Female; Fentanyl; | 2002 |
40 other studies available for ondansetron and Pain
| Article | Year |
|---|---|
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.
Topics: Analgesics; Animals; Binding, Competitive; Cyclic AMP; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP | 2013 |
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P | 2022 |
Prevalence, Risk Factors, and Management of Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy (a Retrospective Multicentric Study).
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dexamethasone; Female; Gastrectomy; Gastroesophageal Re | 2023 |
Emergency procedural sedation in children.
Topics: Anesthetics, Dissociative; Antiemetics; Child; Contraindications, Drug; Emergency Service, Hospital; | 2020 |
Use of Prophylactic Ondansetron with Intravenous Opioids in Emergency Department Patients: A Prospective Observational Pilot Study.
Topics: Administration, Intravenous; Adult; Aged; Analgesics, Opioid; Antibiotic Prophylaxis; Antiemetics; D | 2017 |
White-Lipped Tree Viper (Cryptelytrops albolabris) Envenomation in an American Viper Keeper.
Topics: Adult; Analgesics, Opioid; Animals; Antiemetics; Antivenins; Dyspnea; Emergency Service, Hospital; F | 2017 |
Antinociceptive and anti-inflammatory effects of 1,2-bis-(4 methoxyphenylselanyl) styrene in mice: involvement of the serotonergic system.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Edema; Foot; Male; | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy | 2018 |
Enhanced descending pain facilitation in acute traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Hyperalgesia; Male; Ondansetron; Pain; Rats; Rats, Sprague-Dawle | 2019 |
The use of a clinical database in an anesthesia unit: focus on its limits.
Topics: Anesthesia; Anesthesiology; Automation; Databases, Factual; Humans; Morphine; Ondansetron; Pain; Pai | 2015 |
The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Cytochrome P-450 CYP2D6; Drug Interactions; | 2014 |
Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors.
Topics: Analgesics; Animals; Injections, Spinal; Male; Nefopam; Ondansetron; Pain; Phenols; Rats, Sprague-Da | 2015 |
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.
Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; | 2015 |
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic A | 2015 |
Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice.
Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Isatin; Mecamylamine; Mice; Morphin | 2016 |
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Medulla Oblongata | 2009 |
Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapen | 2010 |
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.
Topics: Analgesics; Analgesics, Opioid; Animals; Dilatation; Electrophysiology; gamma-Aminobutyric Acid; Hyp | 2011 |
Arresting the development of morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Ant | 2011 |
How can 5-HT(3) receptor antagonists exert analgesic properties?
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Hand; Humans; Male; Ondansetron; Pain; Propofo | 2012 |
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A | 2012 |
Descending serotonergic facilitation mediated through rat spinal 5HT3 receptors is unaltered following carrageenan inflammation.
Topics: Animals; Brain Stem; Carrageenan; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stim | 2004 |
The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury.
Topics: 5,6-Dihydroxytryptamine; Animals; Behavior, Animal; Biguanides; Dose-Response Relationship, Drug; Dr | 2004 |
Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin.
Topics: Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cell Count; | 2005 |
Evidence of a role for descending serotonergic facilitation in a rat model of cancer-induced bone pain.
Topics: Animals; Behavior, Animal; Bone Diseases; Cell Line, Tumor; Disease Models, Animal; Dose-Response Re | 2006 |
Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Antiemetics; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Antinociception: mechanistic studies on the action of MD-354 and clonidine. Part 1. The 5-HT3 component.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clonidin | 2005 |
Drug utilization review on a tertiary palliative care unit.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Anxiety Agents; Cost-Benefit Analysis; Drug | 2006 |
Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord.
Topics: Analgesia; Analgesics, Opioid; Animals; Biguanides; Dose-Response Relationship, Drug; Formaldehyde; | 2006 |
The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Isoflurane; Male; Mice; Mi | 2006 |
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Topics: Afferent Pathways; Animals; Drug Tolerance; Dynorphins; Hyperalgesia; Male; Morphine; Neurons; Ondan | 2007 |
[Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress].
Topics: Aging; Analgesics; Animals; Female; Inflammation; Male; Ondansetron; Pain; Phenylalanine; Pregnancy; | 2007 |
Successful control of intractable nausea and vomiting requiring combined ondansetron and haloperidol in a patient with advanced cancer.
Topics: Analgesics; Bone Neoplasms; Breast Neoplasms; Drug Therapy, Combination; Female; Haloperidol; Humans | 1994 |
Treatment of acute gouty arthritis with the 5-hydroxytryptamine antagonist ondansetron.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Contraindications; Eso | 1994 |
Ondansetron blocks nifedipine-induced analgesia in rats.
Topics: Analgesia; Analgesics; Animals; Dimethyl Sulfoxide; Injections, Intraperitoneal; Male; Nifedipine; O | 1996 |
Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Colon; Granisetron; Indoles; Male; Mus | 1996 |
Prevention of morphine discontinuation phenomenon in mice by ondansetron, a selective 5-HT3 antagonist.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Female; Male; Mice; Morphine; Morphi | 1996 |
An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat.
Topics: Anesthesia; Animals; Carrageenan; Electric Stimulation; Male; Myelitis; Nerve Fibers; Nerve Fibers, | 2000 |
Receptor mediation of 5-HT-induced inflammation and nociception in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Ketanserin; M | 1992 |
The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension.
Topics: Animals; Blood Pressure; Duodenum; Granisetron; Imidazoles; Indazoles; Indoles; Male; Morphine; Musc | 1990 |