lactic acid and Pain
lactic acid has been researched along with Pain in 108 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin." | 9.34 | Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020) |
| "Milnacipran, a serotonin/norepinephrine reuptake inhibitor, has been approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM)." | 9.20 | Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Blate, M; Coplan, JD; Kang, G; Lange, G; Mao, X; Natelson, BH; Shungu, DC; Togo, F; Vu, D; Weiduschat, N, 2015) |
| "In this work, we propose a surgical suture that can sustainably release diclofenac (DF) for the local pain relief of surgical wounds." | 7.85 | Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation. ( Choy, YB; Heo, CY; Huh, BK; Kim, BH; Kim, KR; Kim, SN; Lee, SH; Park, CG, 2017) |
| "This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb." | 7.85 | Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017) |
| " We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers." | 7.81 | Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015) |
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 7.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| "A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or beta-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic." | 7.76 | Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic. ( Koho, NM; Korolainen, RV; Leppäluoto, J; Mykkänen, AK; Niinistö, KE; Pösö, AR; Raekallio, MR; Ruohoniemi, MO, 2010) |
| " We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin." | 5.34 | Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020) |
| "Milnacipran, a serotonin/norepinephrine reuptake inhibitor, has been approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM)." | 5.20 | Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Blate, M; Coplan, JD; Kang, G; Lange, G; Mao, X; Natelson, BH; Shungu, DC; Togo, F; Vu, D; Weiduschat, N, 2015) |
| "We employed the 'delayed onset of muscle soreness' (DOMS) and the 'hypertonic saline' muscle pain models in combination with muscle microdialysis to evaluate the role of potentially algesic substances (lactate, glutamate, prostaglandin E2 (PGE2), nitric oxide (NO) and substance P (SP)) in the development of human muscle pain." | 5.10 | Release of algesic substances in human experimental muscle pain. ( Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J, 2002) |
| "A total of 32 rosacea patients (25 with the papulopustular type of rosacea and 7 with the erythematotelangiectatic type) and 32 healthy persons were single-blind tested with a solution of 5% lactic acid and pure water applied to their cheeks." | 5.09 | Stinging and rosacea. ( Berg, M; Fischer, T; Lonne-Rahm, SB, 1999) |
| "Single doses of fentanyl analgesia can reduce the physiologic/behavioral measures of pain and stress associated with mechanical ventilation in preterm infants." | 5.08 | Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates. ( Anand, KJ; de Almeida, MF; Guinsburg, R; Kopelman, BI; Miyoshi, MH; Peres, Cde A, 1998) |
| "The PCMN provided a sustained release of capsaicin in vitro and inhibited carrageenan-induced inflammatory pain in mouse model in vivo." | 3.85 | Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. ( Arulsamy, N; Baskaran, M; Baskaran, P; Thyagarajan, B, 2017) |
| "In this work, we propose a surgical suture that can sustainably release diclofenac (DF) for the local pain relief of surgical wounds." | 3.85 | Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation. ( Choy, YB; Heo, CY; Huh, BK; Kim, BH; Kim, KR; Kim, SN; Lee, SH; Park, CG, 2017) |
| "This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb." | 3.85 | Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017) |
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 3.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| " We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers." | 3.81 | Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015) |
| "The objective of this study was to test the hypothesis that the kappa agonist U69,593 and the kappa antagonist norbinaltorphimine would produce pronociceptive and antinociceptive effects, respectively, in an assay of pain-depressed behavior." | 3.76 | Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats. ( Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M, 2010) |
| "A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or beta-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic." | 3.76 | Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic. ( Koho, NM; Korolainen, RV; Leppäluoto, J; Mykkänen, AK; Niinistö, KE; Pösö, AR; Raekallio, MR; Ruohoniemi, MO, 2010) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Nine patients with McArdle disease, one with the partial glycolytic defect phosphoglycerate mutase deficiency, and nine matched, healthy subjects performed the classic ischemic forearm protocol and an identical protocol without ischemia." | 2.70 | A nonischemic forearm exercise test for McArdle disease. ( Haller, RG; Jensen, TD; Kazemi-Esfarjani, P; Skomorowska, E; Vissing, J, 2002) |
| "The TcPO2 electrode was attached to the dorsum of the foot." | 2.67 | Transcutaneous oxygen pressure measurements in patients with intermittent claudication. ( Celsing, F; Eriksson, M; Rosfors, S, 1994) |
| "Neonatal pain is often undertreated." | 2.50 | [Maybe it hurts more than we think! Neonatal pain]. ( Mikos, B, 2014) |
| "Pain is an unpleasant sensory experience commonly produced by damage to bodily tissues and it is one of the most significant public health problems, because 21." | 2.43 | Polymer-based biodegradable drug delivery systems in pain management. ( Al Malyan, M; Ashammakhi, N; Becchi, C; Boncinelli, S; Chiellini, F; Nikkola, L; Viitanen, P, 2006) |
| " Moreover, participants in occupations that require chronic use of a muscle but do not elicit profuse sweating, such as musicians, often experience cramps." | 2.39 | Exercise-induced muscle pain, soreness, and cramps. ( Clarkson, PM; Miles, MP, 1994) |
| "Pain is a major problem that burdens the health and economy of societies worldwide." | 1.72 | Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats. ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022) |
| "Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target." | 1.51 | Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice. ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019) |
| "Intractable cancer-related pain complicated by a neuropathic component due to nerve impingement is poorly alleviated even by escalating doses of a strong opioid analgesic." | 1.42 | Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. ( Han, FY; Lam, AL; Smith, MT; Thurecht, KJ; Whittaker, AK, 2015) |
| "Only pH 4 saline and α,β-meATP produced hyperalgesia when given alone." | 1.42 | Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats. ( Gregory, NS; Sluka, KA; Whitley, PE, 2015) |
| "Animal pain is defined by a series of expectations or criteria, one of which is that there should be a physiological stress response associated with noxious stimuli." | 1.42 | Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain. ( Adams, L; Elwood, RW, 2015) |
| "Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment." | 1.40 | Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014) |
| "Pain is associated with stimulation of some behaviors (eg, withdrawal reflexes) but depression of many other behaviors (eg, feeding, locomotion, positively reinforced operant behavior)." | 1.39 | Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats. ( Carroll, FI; Negus, SS; Rosenberg, MB, 2013) |
| "Both lactic acid and morphine were equipotent in the stretching and ICSS procedures." | 1.35 | Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. ( Carlezon, WA; Negus, SS; Pereira Do Carmo, G; Stevenson, GW, 2009) |
| "Pain is the most common and feared symptom for patients, especially those with cancer." | 1.32 | In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems. ( Altunay, H; Hasirci, V; Sendil-Keskin, D; Wise, DL, 2003) |
Research
Studies (108)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (8.33) | 18.7374 |
| 1990's | 15 (13.89) | 18.2507 |
| 2000's | 38 (35.19) | 29.6817 |
| 2010's | 39 (36.11) | 24.3611 |
| 2020's | 7 (6.48) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Huang, R | 1 |
| Han, S | 1 |
| Qiu, Y | 1 |
| Zhou, T | 1 |
| Wu, Y | 1 |
| Du, H | 1 |
| Xu, J | 1 |
| Wei, X | 1 |
| Altarifi, AA | 1 |
| Younis, BA | 1 |
| Nuseir, KQ | 1 |
| Al-Mousa, AA | 1 |
| Qaoud, AK | 1 |
| Alsalem, MI | 1 |
| Neubert, JK | 1 |
| Zhou, LD | 1 |
| Lu, YN | 1 |
| Liu, Q | 1 |
| Shi, XM | 1 |
| Tian, J | 1 |
| Held, S | 1 |
| Rappelt, L | 1 |
| Wiedenmann, T | 1 |
| Deutsch, JP | 1 |
| Röttgen, J | 1 |
| Donath, L | 1 |
| Schmitt, A | 1 |
| Wallat, D | 1 |
| Stangier, C | 1 |
| Martin, JA | 1 |
| Schlesinger-Irsch, U | 1 |
| Boecker, H | 1 |
| How, KN | 1 |
| Lim, PY | 1 |
| Wan Ahmad Kammal, WSL | 1 |
| Shamsudin, N | 1 |
| Astokorki, A | 1 |
| Flood, A | 1 |
| Mauger, A | 1 |
| Baskaran, M | 1 |
| Baskaran, P | 1 |
| Arulsamy, N | 1 |
| Thyagarajan, B | 1 |
| Lazenka, MF | 1 |
| Freitas, KC | 2 |
| Henck, S | 1 |
| Negus, SS | 8 |
| Huh, BK | 1 |
| Kim, BH | 1 |
| Kim, SN | 1 |
| Park, CG | 1 |
| Lee, SH | 1 |
| Kim, KR | 1 |
| Heo, CY | 1 |
| Choy, YB | 1 |
| Gdowski, AS | 1 |
| Ranjan, A | 1 |
| Sarker, MR | 1 |
| Vishwanatha, JK | 1 |
| Sakka, M | 1 |
| Leschiera, R | 1 |
| Le Gall-Ianotto, C | 1 |
| Gouin, O | 1 |
| L'herondelle, K | 1 |
| Buscaglia, P | 1 |
| Mignen, O | 1 |
| Philbé, JL | 1 |
| Saguet, T | 1 |
| Carré, JL | 1 |
| Misery, L | 1 |
| Lebonvallet, N | 1 |
| Vaegter, HB | 1 |
| Bjerregaard, LK | 1 |
| Redin, MM | 1 |
| Rasmussen, SH | 1 |
| Graven-Nielsen, T | 1 |
| Alexander, KS | 1 |
| Rodriguez, TR | 1 |
| Sarfo, AN | 1 |
| Patton, TB | 1 |
| Miller, LL | 1 |
| Haddican, M | 1 |
| Gagliotti, M | 1 |
| Lebwohl, M | 1 |
| Leitl, MD | 2 |
| Onvani, S | 1 |
| Bowers, MS | 1 |
| Cheng, K | 2 |
| Rice, KC | 2 |
| Carlezon, WA | 2 |
| Banks, ML | 1 |
| Pollak, KA | 1 |
| Swenson, JD | 1 |
| Vanhaitsma, TA | 1 |
| Hughen, RW | 1 |
| Jo, D | 1 |
| White, AT | 1 |
| Light, KC | 1 |
| Schweinhardt, P | 1 |
| Amann, M | 2 |
| Light, AR | 2 |
| Smith, SA | 1 |
| Kwilasz, AJ | 2 |
| Abdullah, RA | 1 |
| Poklis, JL | 1 |
| Lichtman, AH | 1 |
| Oh, M | 1 |
| Lee, J | 1 |
| Kim, S | 1 |
| Cho, SA | 1 |
| Lee, E | 1 |
| Yeon, JH | 1 |
| He, QQ | 1 |
| Liu, W | 1 |
| Wang, XM | 1 |
| Li, L | 1 |
| Lai, W | 1 |
| Liang, H | 1 |
| Gao, XH | 1 |
| Shin, K | 1 |
| An, S | 1 |
| Smirmaul, BP | 1 |
| Mikos, B | 1 |
| Yoneda, T | 1 |
| Hiasa, M | 1 |
| Nagata, Y | 1 |
| Okui, T | 1 |
| White, F | 1 |
| Han, FY | 1 |
| Thurecht, KJ | 1 |
| Lam, AL | 1 |
| Whittaker, AK | 1 |
| Smith, MT | 1 |
| Hillhouse, TM | 1 |
| Sareban, M | 1 |
| Zügel, D | 1 |
| Koehler, K | 1 |
| Hartveg, P | 1 |
| Zügel, M | 1 |
| Schumann, U | 1 |
| Steinacker, JM | 1 |
| Treff, G | 1 |
| Natelson, BH | 1 |
| Vu, D | 1 |
| Mao, X | 1 |
| Weiduschat, N | 1 |
| Togo, F | 1 |
| Lange, G | 1 |
| Blate, M | 1 |
| Kang, G | 1 |
| Coplan, JD | 1 |
| Shungu, DC | 1 |
| Hoang, BX | 1 |
| Shaw, DG | 1 |
| Han, B | 1 |
| Fang, JY | 1 |
| Nimni, M | 1 |
| Gregory, NS | 1 |
| Whitley, PE | 1 |
| Sluka, KA | 1 |
| Jha, MK | 1 |
| Song, GJ | 1 |
| Lee, MG | 1 |
| Jeoung, NH | 1 |
| Go, Y | 1 |
| Harris, RA | 1 |
| Park, DH | 1 |
| Kook, H | 1 |
| Lee, IK | 1 |
| Suk, K | 1 |
| Elwood, RW | 1 |
| Adams, L | 1 |
| Yu, YH | 1 |
| Hsu, YH | 1 |
| Chou, YC | 1 |
| Fan, CL | 1 |
| Ueng, SW | 1 |
| Kau, YC | 1 |
| Liu, SJ | 1 |
| Sabow, AB | 1 |
| Goh, YM | 1 |
| Zulkifli, I | 1 |
| Sazili, AQ | 1 |
| Kaka, U | 1 |
| Kadi, MZAA | 1 |
| Ebrahimi, M | 1 |
| Nakyinsige, K | 1 |
| Adeyemi, KD | 1 |
| Chéhère, B | 1 |
| Bougault, V | 1 |
| Gicquello, A | 1 |
| Wallaert, B | 1 |
| Baiamonte, BA | 1 |
| Kraemer, RR | 3 |
| Chabreck, CN | 1 |
| Reynolds, ML | 1 |
| McCaleb, KM | 1 |
| Shaheen, GL | 1 |
| Hollander, DB | 3 |
| Kilpatrick, MW | 1 |
| Ramadan, ZG | 1 |
| Reeves, GV | 1 |
| Francois, M | 1 |
| Blakeney, A | 1 |
| Castracane, VD | 2 |
| Duffield, R | 1 |
| Carney, M | 1 |
| Karppinen, S | 1 |
| Pavlov, OO | 1 |
| Niinistö, KE | 1 |
| Korolainen, RV | 1 |
| Raekallio, MR | 1 |
| Mykkänen, AK | 1 |
| Koho, NM | 1 |
| Ruohoniemi, MO | 1 |
| Leppäluoto, J | 1 |
| Pösö, AR | 1 |
| Pereira Do Carmo, G | 1 |
| Stevenson, GW | 1 |
| Weber, U | 1 |
| Reitinger, A | 1 |
| Szusz, R | 1 |
| Hellmich, C | 1 |
| Steinlechner, B | 1 |
| Hager, H | 1 |
| Mora, B | 1 |
| Selzer, M | 1 |
| Hiesmayr, M | 1 |
| Kober, A | 1 |
| Jeong, I | 1 |
| Kim, BS | 1 |
| Lee, H | 1 |
| Lee, KM | 1 |
| Shim, I | 1 |
| Kang, SK | 1 |
| Yin, CS | 1 |
| Hahm, DH | 1 |
| Davis, JK | 1 |
| Green, JM | 1 |
| Morrissey, EM | 1 |
| Rosenberg, M | 1 |
| Tosi, G | 1 |
| Vergoni, AV | 1 |
| Ruozi, B | 1 |
| Bondioli, L | 1 |
| Badiali, L | 1 |
| Rivasi, F | 1 |
| Costantino, L | 1 |
| Forni, F | 1 |
| Vandelli, MA | 1 |
| Aldayel, A | 1 |
| Jubeau, M | 2 |
| McGuigan, M | 1 |
| Nosaka, K | 4 |
| Flodgren, GM | 1 |
| Crenshaw, AG | 1 |
| Hellström, F | 1 |
| Fahlström, M | 1 |
| LaBan, MM | 1 |
| Nagarajan, R | 1 |
| Riutta, JC | 1 |
| de Melo, NF | 1 |
| Grillo, R | 1 |
| Guilherme, VA | 1 |
| de Araujo, DR | 1 |
| de Paula, E | 1 |
| Rosa, AH | 1 |
| Fraceto, LF | 1 |
| Cho, HJ | 1 |
| Chung, BY | 1 |
| Lee, HB | 1 |
| Kim, HO | 1 |
| Park, CW | 1 |
| Lee, CH | 1 |
| Rosenberg, MB | 1 |
| Carroll, FI | 1 |
| Pullinen, T | 1 |
| Mero, A | 1 |
| Huttunen, P | 1 |
| Pakarinen, A | 2 |
| Komi, PV | 1 |
| Kazemi-Esfarjani, P | 1 |
| Skomorowska, E | 1 |
| Jensen, TD | 1 |
| Haller, RG | 1 |
| Vissing, J | 1 |
| Tegeder, L | 1 |
| Zimmermann, J | 1 |
| Meller, ST | 1 |
| Geisslinger, G | 2 |
| Sendil, D | 2 |
| Bonney, IM | 1 |
| Carr, DB | 2 |
| Lipkowski, AW | 1 |
| Wise, DL | 4 |
| Hasirci, V | 4 |
| Durand, RJ | 1 |
| Trynicki, JL | 1 |
| Larock, D | 1 |
| Hebert, EP | 1 |
| Sendil-Keskin, D | 1 |
| Altunay, H | 1 |
| Ahtiainen, JP | 1 |
| Kraemer, WJ | 2 |
| Häkkinen, K | 1 |
| Bonney, I | 1 |
| Goudas, LC | 1 |
| Shuster, L | 1 |
| Achten, J | 1 |
| Halson, SL | 1 |
| Moseley, L | 1 |
| Rayson, MP | 1 |
| Casey, A | 1 |
| Jeukendrup, AE | 1 |
| Dratwa, M | 1 |
| Wilkie, M | 1 |
| Ryckelynck, JP | 1 |
| ter Wee, PM | 1 |
| Rutherford, P | 1 |
| Michel, C | 1 |
| Hopwood, A | 1 |
| Curtis, L | 1 |
| Denys, N | 1 |
| Divino Filho, JC | 1 |
| Faict, D | 1 |
| Chen, PC | 1 |
| Kohane, DS | 1 |
| Park, YJ | 1 |
| Bartlett, RH | 1 |
| Langer, R | 1 |
| Yang, VC | 1 |
| Chatard, JC | 1 |
| Atlaoui, D | 1 |
| Farjanel, J | 1 |
| Louisy, F | 1 |
| Rastel, D | 1 |
| Guézennec, CY | 1 |
| Rosendal, L | 1 |
| Larsson, B | 1 |
| Kristiansen, J | 1 |
| Peolsson, M | 1 |
| Søgaard, K | 1 |
| Kjær, M | 1 |
| Sørensen, J | 1 |
| Gerdle, B | 1 |
| Wallman, KE | 1 |
| Morton, AR | 1 |
| Goodman, C | 1 |
| Grove, R | 1 |
| Lafaurie, M | 1 |
| Dolivo, M | 1 |
| Porcher, R | 1 |
| Rudant, J | 1 |
| Madelaine, I | 1 |
| Molina, JM | 1 |
| Christophersen, OA | 1 |
| Haug, A | 1 |
| Naves, LA | 1 |
| McCleskey, EW | 2 |
| Hinckson, EA | 1 |
| Hopkins, WG | 1 |
| Edwards, JS | 1 |
| Pfitzinger, P | 1 |
| Hellemans, J | 1 |
| Al Malyan, M | 1 |
| Becchi, C | 1 |
| Nikkola, L | 1 |
| Viitanen, P | 1 |
| Boncinelli, S | 1 |
| Chiellini, F | 1 |
| Ashammakhi, N | 1 |
| Desgorces, FD | 1 |
| Sénégas, X | 1 |
| Garcia, J | 1 |
| Decker, L | 1 |
| Noirez, P | 1 |
| Sartorio, A | 1 |
| Marinone, PG | 1 |
| Agosti, F | 1 |
| Van Hoecke, J | 1 |
| Maffiuletti, NA | 1 |
| Miyama, M | 1 |
| Luís, AL | 1 |
| Rodrigues, JM | 1 |
| Geuna, S | 1 |
| Amado, S | 1 |
| Shirosaki, Y | 1 |
| Lee, JM | 1 |
| Fregnan, F | 1 |
| Lopes, MA | 1 |
| Veloso, AP | 1 |
| Ferreira, AJ | 1 |
| Santos, JD | 1 |
| Armada-Da-silva, PA | 1 |
| Varejão, AS | 1 |
| Maurício, AC | 1 |
| Yokota, T | 1 |
| Wallensten, R | 1 |
| Karlsson, J | 1 |
| Mengshoel, AM | 1 |
| Saugen, E | 1 |
| Forre, O | 1 |
| Vøllestad, NK | 1 |
| Miles, MP | 1 |
| Clarkson, PM | 2 |
| Rosfors, S | 1 |
| Celsing, F | 1 |
| Eriksson, M | 1 |
| Flynn, TW | 1 |
| Connery, SM | 1 |
| Smutok, MA | 1 |
| Zeballos, RJ | 1 |
| Weisman, IM | 1 |
| Fletcher, D | 1 |
| Le Corre, P | 1 |
| Guilbaud, G | 1 |
| Le Verge, R | 1 |
| Cohen, O | 1 |
| Steiner, I | 1 |
| Argov, Z | 1 |
| Ashkenazi, A | 1 |
| Diment, J | 1 |
| Saada, A | 1 |
| River, Y | 1 |
| Gleeson, M | 1 |
| Blannin, AK | 1 |
| Walsh, NP | 1 |
| Field, CN | 1 |
| Pritchard, JC | 1 |
| Guinsburg, R | 1 |
| Kopelman, BI | 1 |
| Anand, KJ | 1 |
| de Almeida, MF | 1 |
| Peres, Cde A | 1 |
| Miyoshi, MH | 1 |
| De Letter, EA | 1 |
| Piette, MH | 1 |
| Okuda, T | 1 |
| Wakita, K | 1 |
| Tsuchiya, N | 1 |
| Hatsuoka, K | 1 |
| Koga, Y | 1 |
| Kaetsu, I | 1 |
| Sayers, SP | 1 |
| Garry, MG | 1 |
| Jackson, DL | 1 |
| Geier, HE | 1 |
| Southam, M | 1 |
| Hargreaves, KM | 1 |
| Riggs, JE | 1 |
| Schochet, SS | 1 |
| Webb, RW | 1 |
| Lonne-Rahm, SB | 1 |
| Fischer, T | 1 |
| Berg, M | 1 |
| Ross, G | 1 |
| Grabill, J | 1 |
| McDevitt, E | 1 |
| Sutherland, SP | 1 |
| Cook, SP | 1 |
| Vetter, G | 1 |
| Tegeder, I | 1 |
| Coleman, WP | 1 |
| Ikeda, Y | 1 |
| Ueno, A | 1 |
| Naraba, H | 1 |
| Oh-ishi, S | 1 |
| Volek, JS | 1 |
| Rubin, MR | 1 |
| Gómez, AL | 1 |
| Ratamess, NA | 1 |
| Gaynor, P | 1 |
| Newton, M | 1 |
| Sacco, P | 1 |
| Takita, M | 1 |
| Mikuni, M | 1 |
| Takahashi, K | 1 |
| Ljunggren, G | 2 |
| Johansson, SE | 1 |
| Berg, A | 1 |
| Späth, M | 1 |
| Rokitzki, L | 1 |
| Staiger, J | 1 |
| Keul, J | 1 |
| Angelos, MG | 1 |
| Whiteside, K | 1 |
| Hamilton, GC | 1 |
| Sinkeler, SP | 1 |
| Wevers, RA | 1 |
| Joosten, EM | 1 |
| Binkhorst, RA | 1 |
| Oei, LT | 1 |
| Van't Hof, MA | 1 |
| De Haan, AF | 1 |
| Cannon, RO | 2 |
| Leon, MB | 1 |
| Watson, RM | 1 |
| Rosing, DR | 1 |
| Epstein, SE | 1 |
| Borg, G | 1 |
| Ceci, R | 1 |
Clinical Trials (8)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "The Effect of Milnacipran or Placebo on Ventricular Lactate Levels and Fibromyalgia Induced Brain Fog."[NCT01108731] | Phase 2/Phase 3 | 37 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| Influence of Electrode Positioning and Current Type on Muscle Fatigability, Force Generation, Perceived Discomfort and Neuromuscular Adaptations Induced by Neuromuscular Electric Stimulation: Implications on Rehabilitation[NCT04200677] | 30 participants (Actual) | Interventional | 2020-01-10 | Completed | |||
| Effects of Different Modalities of Medium and Low Frequency Electrical Stimulation in the Generation of Evoked Torque, Sensory Discomfort, Muscle Fatigue and Inheritance Peripheral Oxygen Supply in the Triceps Surae Muscle.[NCT05894044] | 44 participants (Anticipated) | Interventional | 2023-05-23 | Recruiting | |||
| Oral 10% Dextrose Versus Sodium Dextrose Formula in Performance of Soccer Athlete. A Double-Blind Cross Over Randomized Controlled Trial[NCT04206579] | 30 participants (Actual) | Interventional | 2019-03-25 | Completed | |||
| Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy.[NCT04073173] | Phase 4 | 80 participants (Anticipated) | Interventional | 2020-11-01 | Not yet recruiting | ||
| The Underlying Mechanisms From Exercise-induced Muscle Damage on Force Loss[NCT02125643] | Phase 1 | 3 participants (Actual) | Interventional | 2014-08-31 | Terminated (stopped due to Protocol was deem insufficient to answer research question) | ||
| Evaluation of Cilostazol in Combination With L-Carnitine in Subjects With Intermittent Claudication[NCT00822172] | Phase 4 | 164 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial[NCT03193294] | 151 participants (Actual) | Interventional | 2016-11-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Change in Ventricular Lactate Levels in the Brain
Ventricular lactate levels will be assessed before and at the end of the trial using a scanning method known as magnetic resonance spectroscopy (MRS), which is used to determine the presence and quantity of a number of chemicals in the brain. (NCT01108731)
Timeframe: Baseline and 2 months
| Intervention | international units (iu) (Mean) |
|---|---|
| Patients Taking the Drug Minalcipran | -0.87 |
| Patients Taking the Placebo | 0.32 |
Change in Widespread Pain
Pain was assessed using a visual analog scale (VAS) ranging from 0 (no pain) to 10 (worst pain ever). The baseline value recorded was widespread pain at the time of assessment and the 2 months follow value recorded was widespread pain over the week prior to assessment. (NCT01108731)
Timeframe: 2 months
| Intervention | units on a scale (Mean) |
|---|---|
| Patients Taking the Drug Minalcipran | -1.24 |
| Patients Taking the Placebo | 0.66 |
Change in Cognitive Function Assessed by the no Cue Condition of the Attention Network Test (ANT).
The Attention Network Test (ANT) is a computerized test designed to evaluate the efficiency of the attention network. The ANT consists of a set of cued reaction time tasks to assess vigilance and efficiency to detect novel visual stimuli. The ANT also includes a set of flanker tasks during which a decision needs to be made about whether the orientation of a central stimulus is congruent or incongruent with a set of flanking arrows. Scores on the cued reaction time tasks (no cue, centre cue, double cue) reflect latency to respond measured in milliseconds (slower performance equals greater values). The score on the flanker task reflecting executive attention is derived by subtracting obtained latencies on the congruent flanker from the incongruent condition. Based on our prior work, we are hypothesizing that drug treated Ss will show improved performance on the no cue reaction time condition and on the derived executive attention variable compared to placebo treated. (NCT01108731)
Timeframe: Baseline and 2 months
| Intervention | latency to respond (msecs.) (Mean) | |
|---|---|---|
| No cue condition | Executive attention | |
| Patients Taking the Drug Minalcipran | -79.56 | -68.73 |
| Patients Taking the Placebo | -35.00 | -34.77 |
Change From Baseline in Claudication Onset Time at Day 180
Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. The time during the conduct of the exercise treadmill test at which the subject first reported claudication symptoms is referred to as the claudication onset time (COT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180
| Intervention | Log Minutes (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 1.065 |
| Cilostazol + Placebo | 0.896 |
Change From Baseline in Claudication Onset Time at Day 90
Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. The time during the conduct of the exercise treadmill test at which the subject first reported claudication symptoms is referred to as the claudication onset time (COT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 90
| Intervention | Log Minutes (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 1.001 |
| Cilostazol + Placebo | 0.815 |
Change From Baseline in Peak Walking Time (PWT) at Day 180
Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180
| Intervention | Log Minutes (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 0.241 |
| Cilostazol + Placebo | 0.134 |
Change From Baseline in Peak Walking Time at Day 180
Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180
| Intervention | Log Minutes (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 0.267 |
| Cilostazol + Placebo | 0.145 |
Change From Baseline in Peak Walking Time at Day 90
Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 90
| Intervention | Log Minutes (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 0.166 |
| Cilostazol + Placebo | 0.139 |
Change From Baseline in Walking Impairment Questionnaire for Walking Distance at Day 180
Subjects completed the Walking Impairment Questionnaire (WIQ) whereby they were asked about their maximal walking distance before having to rest as a result of claudication symptoms associated with their peripheral artery disease (PAD). The WIQ was administered at the Baseline, Day 90, and Day 180 visits. On the WIQ subjects were asked a series of questions related to their degree of physical difficulty that best described how hard it was for the subject to walk on level ground without stopping to rest. The questions began by asking the degree of difficulty walking around indoors, then 50 feet, 150 feet, 300 feet, 600 feet, 900 feet, and lastly 1500 feet. The responses range from None (best outcome) to Slight, then Some, then Much, then lastly Unable (worst outcome). The walking distance score was calculated from the 7 questions in the section by way of a weighted sum. A score of 100 indicated no walking impairment. A score of 0 corresponded to the highest degree of walking impairment (NCT00822172)
Timeframe: Baseline, Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 13.20 |
| Cilostazol + Placebo | 6.57 |
Change From Baseline in Walking Impairment Questionnaire for Walking Distance at Day 90
Subjects completed the Walking Impairment Questionnaire (WIQ) whereby they were asked about their maximal walking distance before having to rest as a result of claudication symptoms associated with their peripheral artery disease (PAD). The WIQ was administered at the Baseline, Day 90, and Day 180 visits. On the WIQ subjects were asked a series of questions related to their degree of physical difficulty that best described how hard it was for the subject to walk on level ground without stopping to rest. The questions began by asking the degree of difficulty walking around indoors, then 50 feet, 150 feet, 300 feet, 600 feet, 900 feet, and lastly 1500 feet. The responses range from None (best outcome) to Slight, then Some, then Much, then lastly Unable (worst outcome). The walking distance score was calculated from the 7 questions in the section by way of a weighted sum. A score of 100 indicated no walking impairment. A score of 0 corresponded to the highest degree of walking impairment (NCT00822172)
Timeframe: Baseline, Day 90
| Intervention | score on a scale (Mean) |
|---|---|
| Cilostazol + L-Carnitine | 12.98 |
| Cilostazol + Placebo | 10.01 |
Reviews
11 reviews available for lactic acid and Pain
| Article | Year |
|---|---|
[Maybe it hurts more than we think! Neonatal pain].
Topics: Alanine; Animals; Blood Pressure; Fetus; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Lac | 2014 |
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain.
Topics: Acid Sensing Ion Channels; Analgesics; Bone and Bones; Bone Neoplasms; Bone Resorption; Gene Express | 2015 |
Caffeine and anaerobic performance: ergogenic value and mechanisms of action.
Topics: Anaerobic Threshold; Bicycling; Blood Glucose; Caffeine; Catecholamines; Central Nervous System Stim | 2009 |
Paucity of muscle metastasis in otherwise widely disseminated cancer: a conundrum.
Topics: Diagnostic Imaging; Edema; Humans; Lactic Acid; Muscle Neoplasms; Muscle, Skeletal; Neoplasm Metasta | 2010 |
An acid-sensing ion channel that detects ischemic pain.
Topics: Acid Sensing Ion Channels; Animals; Hydrogen-Ion Concentration; Ischemia; Lactic Acid; Membrane Prot | 2005 |
Polymer-based biodegradable drug delivery systems in pain management.
Topics: Absorbable Implants; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroida | 2006 |
[Mechanism of anginal pain].
Topics: Angina Pectoris; Animals; Bradykinin; Cats; Coronary Vessels; Dogs; Humans; Ischemia; Lactates; Lact | 1984 |
Exercise-induced muscle pain, soreness, and cramps.
Topics: Creatine Kinase; Exercise; Humans; Lactates; Lactic Acid; Muscle Contraction; Muscle Cramp; Muscle, | 1994 |
Etiology of exercise-induced muscle damage.
Topics: Calcium; Carrier Proteins; Exercise; Glucose; Heat-Shock Proteins; Homeostasis; Humans; Hydrogen; La | 1999 |
Chemical mediators of pain due to tissue damage and ischemia.
Topics: Acetylcholine; Acid Sensing Ion Channels; Adenosine; Adenosine Triphosphate; Afferent Pathways; Anim | 2000 |
Dermal peels.
Topics: Chemexfoliation; Drug Combinations; Ethanol; Humans; Lactic Acid; Pain; Postoperative Care; Resorcin | 2001 |
Trials
20 trials available for lactic acid and Pain
| Article | Year |
|---|---|
Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial.
Topics: Acne Vulgaris; Adult; Chemexfoliation; Double-Blind Method; Drug Combinations; Ethanol; Facial Derma | 2020 |
Images depicting human pain increase exercise-induced pain and impair endurance cycling performance.
Topics: Adult; Bicycling; Female; Heart Rate; Humans; Lactic Acid; Male; Myalgia; Pain; Perception; Physical | 2021 |
Carbohydrate Intake in Form of Gel Is Associated With Increased Gastrointestinal Distress but Not With Performance Differences Compared With Liquid Carbohydrate Ingestion During Simulated Long-Distance Triathlon.
Topics: Adult; Athletes; Athletic Performance; Beverages; Bicycling; Blood Glucose; Colic; Cross-Over Studie | 2016 |
Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Anti-Inflammatory Agents, Non-Steroidal; Attention; Biomarkers; | 2015 |
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid; | 2010 |
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid; | 2010 |
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid; | 2010 |
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid; | 2010 |
Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
Topics: Adiposity; Adult; Female; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Muscle, Skeletal; Muscu | 2010 |
A nonischemic forearm exercise test for McArdle disease.
Topics: Adult; Ammonia; Exercise; Exercise Test; Female; Forearm; Glycogen Storage Disease Type V; Hand Stre | 2002 |
Release of algesic substances in human experimental muscle pain.
Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammatio | 2002 |
Acute hormonal and neuromuscular responses and recovery to forced vs maximum repetitions multiple resistance exercises.
Topics: Electromyography; Electrophysiology; Exercise; Hormones; Human Growth Hormone; Humans; Hydrocortison | 2003 |
Higher dietary carbohydrate content during intensified running training results in better maintenance of performance and mood state.
Topics: Adult; Affect; Catecholamines; Cross-Over Studies; Dietary Carbohydrates; Dose-Response Relationship | 2004 |
Clinical experience with two physiologic bicarbonate/lactate peritoneal dialysis solutions in automated peritoneal dialysis.
Topics: Automation; Bicarbonates; Calcium; Dialysis Solutions; Gases; Humans; Lactic Acid; Pain; Patient Sat | 2003 |
Elastic stockings, performance and leg pain recovery in 63-year-old sportsmen.
Topics: Aged; Bandages; Bicycling; Exercise; Hematocrit; Humans; Lactic Acid; Leg; Male; Middle Aged; Pain; | 2004 |
Treatment of facial lipoatrophy with intradermal injections of polylactic acid in HIV-infected patients.
Topics: Adult; Antiretroviral Therapy, Highly Active; Facial Dermatoses; Female; Follow-Up Studies; HIV Infe | 2005 |
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage.
Topics: Adult; Creatine Kinase, MM Form; Electric Stimulation; Exercise; Human Growth Hormone; Humans; Isome | 2008 |
Protection against muscle damage following fifty drop jumps conferred by ten drop jumps.
Topics: Athletic Injuries; Athletic Performance; Biomarkers; Creatine Kinase; Heart Rate; Humans; Knee; Lact | 2007 |
Transcutaneous oxygen pressure measurements in patients with intermittent claudication.
Topics: Aged; Blood Gas Monitoring, Transcutaneous; Exercise Test; Heart Rate; Humans; Intermittent Claudica | 1994 |
Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates.
Topics: Analgesia; Analgesics, Opioid; Blood Glucose; Catheterization, Central Venous; Double-Blind Method; | 1998 |
Stinging and rosacea.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypersensitivity, Immediate; Lactic Acid; Male; Midd | 1999 |
L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress.
Topics: Adult; Biomarkers; Carnitine; Cross-Over Studies; Cytosol; Double-Blind Method; Exercise; Free Radic | 2002 |
Muscle damage and soreness after endurance exercise of the elbow flexors.
Topics: Adolescent; Adult; Arm; Biomarkers; Creatine Kinase; Elbow; Exercise; Humans; Isometric Contraction; | 2002 |
Other Studies
77 other studies available for lactic acid and Pain
| Article | Year |
|---|---|
Glucocorticoid regulation of lactate release from spinal astrocytes contributes to the induction of spinal LTP of C-fiber-evoked field potentials and the development of mechanical allodynia.
Topics: Animals; Astrocytes; Glucocorticoids; Hyperalgesia; Lactic Acid; Long-Term Potentiation; Mice; Pain; | 2022 |
Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Feeding Beh | 2022 |
Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin.
Topics: Capsaicin; Citrus; Fruit; Humans; Lactic Acid; Pain; Plant Extracts; Skin Diseases; TRPV Cation Chan | 2023 |
Blood Flow Restricted Cycling Impairs Subsequent Jumping But Not Balance Performance Slightly More Than Non-Restricted Cycling: An Acute Randomized Controlled Cross-Over Trial.
Topics: Bicycling; Cross-Over Studies; Female; Heart Rate; Humans; Lactic Acid; Pain; Young Adult | 2023 |
Effects of fitness level and exercise intensity on pain and mood responses.
Topics: Adult; Affect; Exercise; Humans; Lactic Acid; Male; Pain; Pain Threshold; Physical Fitness; Young Ad | 2020 |
Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles.
Topics: Animals; Capsaicin; Cell Survival; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Fluo | 2017 |
Relief of Pain-Depressed Behavior in Rats by Activation of D1-Like Dopamine Receptors.
Topics: Analgesics; Animals; Behavior, Animal; Benzazepines; Conditioning, Operant; Depression; Dopamine Ago | 2017 |
Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation.
Topics: Animals; Diclofenac; Lactic Acid; Pain; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolym | 2017 |
Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain.
Topics: Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dip | 2017 |
A new tool to test active ingredient using lactic acid in vitro, a help to understand cellular mechanism involved in stinging test: An example using a bacterial polysaccharide (Fucogel
Topics: Acid Sensing Ion Channels; Adult; Aged; Animals; Carrier Proteins; Coculture Techniques; Female; Hum | 2018 |
Hypoalgesia after bicycling at lactate threshold is reliable between sessions.
Topics: Adult; Anaerobic Threshold; Bicycling; Female; Humans; Lactic Acid; Male; Muscle, Skeletal; Pain; Pa | 2019 |
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamin | 2019 |
Reduced burning and stinging associated with topical application of lactic acid 10% with strontium versus ammonium lactate 12%.
Topics: Administration, Cutaneous; Adult; Ammonium Hydroxide; Dermatologic Agents; Drug Combinations; Fatty | 2013 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene E | 2014 |
Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects.
Topics: Adenosine Triphosphate; Adult; Exercise; Female; Humans; Lactic Acid; Male; Middle Aged; Muscle Fati | 2014 |
No pain, no gain: somatosensation from skeletal muscle.
Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S | 2014 |
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbam | 2014 |
Regional and seasonal differences in skin irritation and neurosensitivity in Chinese and South Korean women.
Topics: Adult; Capsaicin; China; Dermatitis, Contact; Female; Healthy Volunteers; Humans; Lactic Acid; Pain; | 2015 |
Feedback from group III/IV muscle afferents is not the sensory signal for perception of effort.
Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S | 2014 |
Reply: To PMID 24142455.
Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S | 2014 |
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Delayed-Action Preparations; Ketamine; Lactic Acid; Male; M | 2015 |
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
Topics: Animals; Attention; Behavior, Animal; Edema; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Lactic A | 2015 |
Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control.
Topics: Acidosis; Aldehyde Dehydrogenase; Dichloroacetic Acid; Formaldehyde; Glutathione; Humans; Hydrogen-I | 2015 |
Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats.
Topics: Acid Sensing Ion Channels; Adenosine Triphosphate; Animals; Hydrogen-Ion Concentration; Hyperalgesia | 2015 |
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Edema; Gene Expression Regulation; Hyperalgesia; I | 2015 |
Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain.
Topics: Animals; Behavior, Animal; Brachyura; Electric Stimulation; Hemolymph; Lactic Acid; Pain; Stress, Ph | 2015 |
Sustained relief of pain from osteosynthesis surgery of rib fracture by using biodegradable lidocaine-eluting nanofibrous membranes.
Topics: Absorbable Implants; Anesthetics, Local; Animals; Lactic Acid; Lidocaine; Membranes, Artificial; Nan | 2016 |
Blood parameters and electroencephalographic responses of goats to slaughter without stunning.
Topics: Abattoirs; Anesthesia; Animal Welfare; Animals; Blood Glucose; Calcium; Catecholamines; Consciousnes | 2016 |
Cardiorespiratory Response to Different Exercise Tests in Interstitial Lung Disease.
Topics: Dyspnea; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Lactic Acid; Leg; Lung Disea | 2016 |
Exercise-induced hypoalgesia: Pain tolerance, preference and tolerance for exercise intensity, and physiological correlates following dynamic circuit resistance exercise.
Topics: Exercise Tolerance; Female; Heart Rate; Humans; Lactic Acid; Male; Muscle Fatigue; Pain; Pain Thresh | 2017 |
Load rather than contraction type influences rate of perceived exertion and pain.
Topics: Adolescent; Adult; Heart Rate; Humans; Lactic Acid; Male; Muscle Contraction; Muscle, Skeletal; Pain | 2008 |
Physiological responses and bowling performance during repeated spells of medium-fast bowling.
Topics: Adult; Athletic Performance; Australia; Biophysics; Blood Glucose; Body Temperature; Body Weight; He | 2009 |
[The role of hypoxic syndrome in pathogenesis of experimental stress-lesions].
Topics: Animals; Biomarkers; Disease Models, Animal; Hypoxia; Lactic Acid; Male; Oxygen; Pain; Pain Manageme | 2008 |
Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Biomarkers; Blood Chemical Analysis; Case-Cont | 2010 |
Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Biophysics; Conditioning, Opera | 2009 |
Emergency ambulance transport induces stress in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Ambulances; Blood Pressure; Epinephrine; Heart Rate; Humans; Lactic A | 2009 |
Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats.
Topics: Acupuncture Points; Animals; Bee Venoms; Biocompatible Materials; Delayed-Action Preparations; Drug | 2009 |
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug E | 2010 |
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.
Topics: Animals; Brain; Drug Carriers; Glycopeptides; Lactic Acid; Loperamide; Male; Microscopy, Electron, S | 2010 |
Poly(lactide-co-glycolide) nanocapsules containing benzocaine: influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity.
Topics: Anesthetics, Local; Animals; Benzocaine; Cellulose; Chemistry, Pharmaceutical; Drug Carriers; Hydrog | 2011 |
Quantitative study of stratum corneum ceramides contents in patients with sensitive skin.
Topics: Adult; Back; Ceramides; Erythema; Face; Female; Forearm; Hand; Humans; Lactic Acid; Leg; Male; Pain; | 2012 |
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid R | 2012 |
Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Biophysics; Conditioning, Operant; Depression; | 2013 |
Hormonal responses to a resistance exercise performed under the influence of delayed onset muscle soreness.
Topics: Adult; Electromyography; Epinephrine; Exercise; Humans; Lactic Acid; Leg; Male; Muscle Fatigue; Musc | 2002 |
Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats.
Topics: Analgesics; Animals; Bupivacaine; Drug Delivery Systems; Drug Implants; Enkephalins; Hydromorphone; | 2003 |
RPE, pain, and physiological adjustment to concentric and eccentric contractions.
Topics: Adolescent; Adult; Exercise; Heart Rate; Humans; Hydrocortisone; Lactic Acid; Male; Muscle Contracti | 2003 |
In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Biocompatible Materials; Biodegra | 2003 |
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects.
Topics: Anesthetics, Local; Animals; Biocompatible Materials; Delayed-Action Preparations; Drug Carriers; Ge | 2004 |
Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise.
Topics: Creatine; Female; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Lactic Acid; Microdialysis; Muscle | 2004 |
Physiological responses during a submaximal cycle test in chronic fatigue syndrome.
Topics: Adult; Case-Control Studies; Exercise Test; Exercise Tolerance; Fatigue Syndrome, Chronic; Fear; Fem | 2004 |
[About sugar, lactic acid and pain].
Topics: Blood Glucose; Dietary Carbohydrates; Humans; Lactic Acid; Nerve Fibers, Myelinated; Pain; Receptors | 2005 |
Sea-level performance in runners using altitude tents: a field study.
Topics: Adult; Altitude; Camping; Case-Control Studies; Equipment and Supplies; Exercise Test; Fatigue; Fema | 2005 |
Methods to quantify intermittent exercises.
Topics: Adult; Exercise; Heart Rate; Humans; Lactic Acid; Male; Models, Biological; Muscle Strength; Muscle, | 2007 |
Use of PLGA 90:10 scaffolds enriched with in vitro-differentiated neural cells for repairing rat sciatic nerve defects.
Topics: Animals; Biomechanical Phenomena; Cell Differentiation; Cell Line, Tumor; Hydrogen-Ion Concentration | 2008 |
Histochemical and metabolic changes in lower leg muscles in exercise-induced pain.
Topics: Adolescent; Adult; Biopsy, Needle; Humans; Lactates; Lactic Acid; Leg; Male; Muscles; Pain; Physical | 1984 |
Muscle fatigue in early fibromyalgia.
Topics: Adult; Catecholamines; Electromyography; Exercise; Female; Fibromyalgia; Humans; Lactates; Lactic Ac | 1995 |
Comparison of cardiopulmonary responses to forward and backward walking and running.
Topics: Athletic Injuries; Gait; Heart Rate; Humans; Knee Injuries; Lactates; Lactic Acid; Male; Oxygen Cons | 1994 |
Antinociceptive effect of bupivacaine encapsulated in poly(D,L)-lactide-co-glycolide microspheres in the acute inflammatory pain model of carrageenin-injected rats.
Topics: Acute Disease; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Drug Compounding; Inflammation | 1997 |
Mitochondrial myopathy with atypical subacute presentation.
Topics: Acute Disease; Adult; Biopsy; Disease Progression; Electromyography; Female; Humans; Lactic Acid; Mi | 1998 |
Effect of exercise-induced muscle damage on the blood lactate response to incremental exercise in humans.
Topics: Adult; Bicycling; Creatine Kinase; Exercise; Female; Humans; Lactic Acid; Male; Muscle Weakness; Mus | 1998 |
Can routinely combined analysis of glucose and lactate in vitreous humour be useful in current forensic practice?
Topics: Adult; Aged; Aged, 80 and over; Cause of Death; Child; Forensic Medicine; Glucose; Humans; Lactic Ac | 1998 |
[Prolonged antinociceptive effect of poly (DL-lactic acid)-fentanyl composites after their intrathecal injection in rats].
Topics: Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Carriers; Fentanyl; Injections, Spina | 1999 |
Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release.
Topics: Anesthetics, Local; Animals; Biocompatible Materials; Biodegradation, Environmental; Bradykinin; Bup | 1999 |
Exertional myalgia syndrome associated with diminished serum ammonia elevation in ischemic exercise testing.
Topics: Adult; Ammonia; AMP Deaminase; Biopsy; Chronic Disease; Exercise Test; Humans; Lactic Acid; Male; Mu | 1999 |
Chondral injury after meniscal repair with bioabsorbable arrows.
Topics: Absorbable Implants; Adult; Arthroscopy; Cartilage, Articular; Femur; Humans; Knee Joint; Lactic Aci | 2000 |
Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation.
Topics: Animals; Dinoprostone; Glutamic Acid; Glycerol; Lactic Acid; Male; Microdialysis; Nitrates; Nitric O | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |
Assessment of biodegradable controlled release rod systems for pain relief applications.
Topics: Analgesics, Opioid; Biocompatible Materials; Biodegradation, Environmental; Codeine; Drug Delivery S | 2002 |
Habituation of lactate release responding to stressful stimuli in rat prefrontal cortex in vivo.
Topics: Acoustic Stimulation; Animals; Brain; Diagnosis, Computer-Assisted; Dialysis; Dopamine; Extracellula | 1992 |
Use of submaximal measures of perceived exertion during bicycle ergometer exercise as predictors of maximal work capacity.
Topics: Adult; Exercise Test; Heart Rate; Humans; Lactates; Lactic Acid; Male; Pain; Perception; Physical Ex | 1988 |
Influence of symptom-limited stress on blood lactate behaviour in coronary heart disease (CHD) patients.
Topics: Aged; Exercise Test; Heart Rate; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardial Infarc | 1987 |
Abdominal pain and weakness in an elderly woman.
Topics: Abdomen; Aged; Creatine Kinase; Electrocardiography; Female; Heart Failure; Humans; Isoenzymes; Lact | 1986 |
Improvement of screening in exertional myalgia with a standardized ischemic forearm test.
Topics: Adolescent; Adult; Aged; Ammonia; AMP Deaminase; Child; Child, Preschool; Clinical Enzyme Tests; Fem | 1986 |
Chest pain and "normal" coronary arteries--role of small coronary arteries.
Topics: Adult; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Electrocardiography; Ergonovine; | 1985 |
Myocardial ischemia due to dynamic small vessel coronary artery disease.
Topics: Animals; Cardiac Pacing, Artificial; Cold Temperature; Coronary Circulation; Coronary Disease; Coron | 1985 |
The increase of perceived exertion, aches and pain in the legs, heart rate and blood lactate during exercise on a bicycle ergometer.
Topics: Adult; Bicycling; Heart Rate; Humans; Lactates; Lactic Acid; Leg; Male; Pain; Perception; Physical E | 1985 |