Page last updated: 2024-10-17

lactic acid and Pain

lactic acid has been researched along with Pain in 108 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
" We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin."9.34Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020)
"Milnacipran, a serotonin/norepinephrine reuptake inhibitor, has been approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM)."9.20Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Blate, M; Coplan, JD; Kang, G; Lange, G; Mao, X; Natelson, BH; Shungu, DC; Togo, F; Vu, D; Weiduschat, N, 2015)
"In this work, we propose a surgical suture that can sustainably release diclofenac (DF) for the local pain relief of surgical wounds."7.85Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation. ( Choy, YB; Heo, CY; Huh, BK; Kim, BH; Kim, KR; Kim, SN; Lee, SH; Park, CG, 2017)
"This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb."7.85Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017)
" We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers."7.81Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015)
" Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended."7.81Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015)
"A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or beta-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic."7.76Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic. ( Koho, NM; Korolainen, RV; Leppäluoto, J; Mykkänen, AK; Niinistö, KE; Pösö, AR; Raekallio, MR; Ruohoniemi, MO, 2010)
" We sought to determine the efficacy and safety of Jessner's solution (JS) in comparison with salicylic acid (SA) 30% in the management of acne vulgaris and postacne hyperpigmentation in patients with colored skin."5.34Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial. ( How, KN; Lim, PY; Shamsudin, N; Wan Ahmad Kammal, WSL, 2020)
"Milnacipran, a serotonin/norepinephrine reuptake inhibitor, has been approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM)."5.20Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. ( Blate, M; Coplan, JD; Kang, G; Lange, G; Mao, X; Natelson, BH; Shungu, DC; Togo, F; Vu, D; Weiduschat, N, 2015)
"We employed the 'delayed onset of muscle soreness' (DOMS) and the 'hypertonic saline' muscle pain models in combination with muscle microdialysis to evaluate the role of potentially algesic substances (lactate, glutamate, prostaglandin E2 (PGE2), nitric oxide (NO) and substance P (SP)) in the development of human muscle pain."5.10Release of algesic substances in human experimental muscle pain. ( Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J, 2002)
"A total of 32 rosacea patients (25 with the papulopustular type of rosacea and 7 with the erythematotelangiectatic type) and 32 healthy persons were single-blind tested with a solution of 5% lactic acid and pure water applied to their cheeks."5.09Stinging and rosacea. ( Berg, M; Fischer, T; Lonne-Rahm, SB, 1999)
"Single doses of fentanyl analgesia can reduce the physiologic/behavioral measures of pain and stress associated with mechanical ventilation in preterm infants."5.08Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates. ( Anand, KJ; de Almeida, MF; Guinsburg, R; Kopelman, BI; Miyoshi, MH; Peres, Cde A, 1998)
"The PCMN provided a sustained release of capsaicin in vitro and inhibited carrageenan-induced inflammatory pain in mouse model in vivo."3.85Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. ( Arulsamy, N; Baskaran, M; Baskaran, P; Thyagarajan, B, 2017)
"In this work, we propose a surgical suture that can sustainably release diclofenac (DF) for the local pain relief of surgical wounds."3.85Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation. ( Choy, YB; Heo, CY; Huh, BK; Kim, BH; Kim, KR; Kim, SN; Lee, SH; Park, CG, 2017)
"This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb."3.85Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017)
" Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended."3.81Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015)
" We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers."3.81Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015)
"The objective of this study was to test the hypothesis that the kappa agonist U69,593 and the kappa antagonist norbinaltorphimine would produce pronociceptive and antinociceptive effects, respectively, in an assay of pain-depressed behavior."3.76Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats. ( Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M, 2010)
"A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or beta-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic."3.76Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic. ( Koho, NM; Korolainen, RV; Leppäluoto, J; Mykkänen, AK; Niinistö, KE; Pösö, AR; Raekallio, MR; Ruohoniemi, MO, 2010)
" These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception."3.71Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001)
"Nine patients with McArdle disease, one with the partial glycolytic defect phosphoglycerate mutase deficiency, and nine matched, healthy subjects performed the classic ischemic forearm protocol and an identical protocol without ischemia."2.70A nonischemic forearm exercise test for McArdle disease. ( Haller, RG; Jensen, TD; Kazemi-Esfarjani, P; Skomorowska, E; Vissing, J, 2002)
"The TcPO2 electrode was attached to the dorsum of the foot."2.67Transcutaneous oxygen pressure measurements in patients with intermittent claudication. ( Celsing, F; Eriksson, M; Rosfors, S, 1994)
"Neonatal pain is often undertreated."2.50[Maybe it hurts more than we think! Neonatal pain]. ( Mikos, B, 2014)
"Pain is an unpleasant sensory experience commonly produced by damage to bodily tissues and it is one of the most significant public health problems, because 21."2.43Polymer-based biodegradable drug delivery systems in pain management. ( Al Malyan, M; Ashammakhi, N; Becchi, C; Boncinelli, S; Chiellini, F; Nikkola, L; Viitanen, P, 2006)
" Moreover, participants in occupations that require chronic use of a muscle but do not elicit profuse sweating, such as musicians, often experience cramps."2.39Exercise-induced muscle pain, soreness, and cramps. ( Clarkson, PM; Miles, MP, 1994)
"Pain is a major problem that burdens the health and economy of societies worldwide."1.72Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats. ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022)
"Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target."1.51Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice. ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019)
"Intractable cancer-related pain complicated by a neuropathic component due to nerve impingement is poorly alleviated even by escalating doses of a strong opioid analgesic."1.42Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. ( Han, FY; Lam, AL; Smith, MT; Thurecht, KJ; Whittaker, AK, 2015)
"Only pH 4 saline and α,β-meATP produced hyperalgesia when given alone."1.42Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats. ( Gregory, NS; Sluka, KA; Whitley, PE, 2015)
"Animal pain is defined by a series of expectations or criteria, one of which is that there should be a physiological stress response associated with noxious stimuli."1.42Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain. ( Adams, L; Elwood, RW, 2015)
"Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment."1.40Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014)
"Pain is associated with stimulation of some behaviors (eg, withdrawal reflexes) but depression of many other behaviors (eg, feeding, locomotion, positively reinforced operant behavior)."1.39Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats. ( Carroll, FI; Negus, SS; Rosenberg, MB, 2013)
"Both lactic acid and morphine were equipotent in the stretching and ICSS procedures."1.35Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. ( Carlezon, WA; Negus, SS; Pereira Do Carmo, G; Stevenson, GW, 2009)
"Pain is the most common and feared symptom for patients, especially those with cancer."1.32In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems. ( Altunay, H; Hasirci, V; Sendil-Keskin, D; Wise, DL, 2003)

Research

Studies (108)

TimeframeStudies, this research(%)All Research%
pre-19909 (8.33)18.7374
1990's15 (13.89)18.2507
2000's38 (35.19)29.6817
2010's39 (36.11)24.3611
2020's7 (6.48)2.80

Authors

AuthorsStudies
Huang, R1
Han, S1
Qiu, Y1
Zhou, T1
Wu, Y1
Du, H1
Xu, J1
Wei, X1
Altarifi, AA1
Younis, BA1
Nuseir, KQ1
Al-Mousa, AA1
Qaoud, AK1
Alsalem, MI1
Neubert, JK1
Zhou, LD1
Lu, YN1
Liu, Q1
Shi, XM1
Tian, J1
Held, S1
Rappelt, L1
Wiedenmann, T1
Deutsch, JP1
Röttgen, J1
Donath, L1
Schmitt, A1
Wallat, D1
Stangier, C1
Martin, JA1
Schlesinger-Irsch, U1
Boecker, H1
How, KN1
Lim, PY1
Wan Ahmad Kammal, WSL1
Shamsudin, N1
Astokorki, A1
Flood, A1
Mauger, A1
Baskaran, M1
Baskaran, P1
Arulsamy, N1
Thyagarajan, B1
Lazenka, MF1
Freitas, KC2
Henck, S1
Negus, SS8
Huh, BK1
Kim, BH1
Kim, SN1
Park, CG1
Lee, SH1
Kim, KR1
Heo, CY1
Choy, YB1
Gdowski, AS1
Ranjan, A1
Sarker, MR1
Vishwanatha, JK1
Sakka, M1
Leschiera, R1
Le Gall-Ianotto, C1
Gouin, O1
L'herondelle, K1
Buscaglia, P1
Mignen, O1
Philbé, JL1
Saguet, T1
Carré, JL1
Misery, L1
Lebonvallet, N1
Vaegter, HB1
Bjerregaard, LK1
Redin, MM1
Rasmussen, SH1
Graven-Nielsen, T1
Alexander, KS1
Rodriguez, TR1
Sarfo, AN1
Patton, TB1
Miller, LL1
Haddican, M1
Gagliotti, M1
Lebwohl, M1
Leitl, MD2
Onvani, S1
Bowers, MS1
Cheng, K2
Rice, KC2
Carlezon, WA2
Banks, ML1
Pollak, KA1
Swenson, JD1
Vanhaitsma, TA1
Hughen, RW1
Jo, D1
White, AT1
Light, KC1
Schweinhardt, P1
Amann, M2
Light, AR2
Smith, SA1
Kwilasz, AJ2
Abdullah, RA1
Poklis, JL1
Lichtman, AH1
Oh, M1
Lee, J1
Kim, S1
Cho, SA1
Lee, E1
Yeon, JH1
He, QQ1
Liu, W1
Wang, XM1
Li, L1
Lai, W1
Liang, H1
Gao, XH1
Shin, K1
An, S1
Smirmaul, BP1
Mikos, B1
Yoneda, T1
Hiasa, M1
Nagata, Y1
Okui, T1
White, F1
Han, FY1
Thurecht, KJ1
Lam, AL1
Whittaker, AK1
Smith, MT1
Hillhouse, TM1
Sareban, M1
Zügel, D1
Koehler, K1
Hartveg, P1
Zügel, M1
Schumann, U1
Steinacker, JM1
Treff, G1
Natelson, BH1
Vu, D1
Mao, X1
Weiduschat, N1
Togo, F1
Lange, G1
Blate, M1
Kang, G1
Coplan, JD1
Shungu, DC1
Hoang, BX1
Shaw, DG1
Han, B1
Fang, JY1
Nimni, M1
Gregory, NS1
Whitley, PE1
Sluka, KA1
Jha, MK1
Song, GJ1
Lee, MG1
Jeoung, NH1
Go, Y1
Harris, RA1
Park, DH1
Kook, H1
Lee, IK1
Suk, K1
Elwood, RW1
Adams, L1
Yu, YH1
Hsu, YH1
Chou, YC1
Fan, CL1
Ueng, SW1
Kau, YC1
Liu, SJ1
Sabow, AB1
Goh, YM1
Zulkifli, I1
Sazili, AQ1
Kaka, U1
Kadi, MZAA1
Ebrahimi, M1
Nakyinsige, K1
Adeyemi, KD1
Chéhère, B1
Bougault, V1
Gicquello, A1
Wallaert, B1
Baiamonte, BA1
Kraemer, RR3
Chabreck, CN1
Reynolds, ML1
McCaleb, KM1
Shaheen, GL1
Hollander, DB3
Kilpatrick, MW1
Ramadan, ZG1
Reeves, GV1
Francois, M1
Blakeney, A1
Castracane, VD2
Duffield, R1
Carney, M1
Karppinen, S1
Pavlov, OO1
Niinistö, KE1
Korolainen, RV1
Raekallio, MR1
Mykkänen, AK1
Koho, NM1
Ruohoniemi, MO1
Leppäluoto, J1
Pösö, AR1
Pereira Do Carmo, G1
Stevenson, GW1
Weber, U1
Reitinger, A1
Szusz, R1
Hellmich, C1
Steinlechner, B1
Hager, H1
Mora, B1
Selzer, M1
Hiesmayr, M1
Kober, A1
Jeong, I1
Kim, BS1
Lee, H1
Lee, KM1
Shim, I1
Kang, SK1
Yin, CS1
Hahm, DH1
Davis, JK1
Green, JM1
Morrissey, EM1
Rosenberg, M1
Tosi, G1
Vergoni, AV1
Ruozi, B1
Bondioli, L1
Badiali, L1
Rivasi, F1
Costantino, L1
Forni, F1
Vandelli, MA1
Aldayel, A1
Jubeau, M2
McGuigan, M1
Nosaka, K4
Flodgren, GM1
Crenshaw, AG1
Hellström, F1
Fahlström, M1
LaBan, MM1
Nagarajan, R1
Riutta, JC1
de Melo, NF1
Grillo, R1
Guilherme, VA1
de Araujo, DR1
de Paula, E1
Rosa, AH1
Fraceto, LF1
Cho, HJ1
Chung, BY1
Lee, HB1
Kim, HO1
Park, CW1
Lee, CH1
Rosenberg, MB1
Carroll, FI1
Pullinen, T1
Mero, A1
Huttunen, P1
Pakarinen, A2
Komi, PV1
Kazemi-Esfarjani, P1
Skomorowska, E1
Jensen, TD1
Haller, RG1
Vissing, J1
Tegeder, L1
Zimmermann, J1
Meller, ST1
Geisslinger, G2
Sendil, D2
Bonney, IM1
Carr, DB2
Lipkowski, AW1
Wise, DL4
Hasirci, V4
Durand, RJ1
Trynicki, JL1
Larock, D1
Hebert, EP1
Sendil-Keskin, D1
Altunay, H1
Ahtiainen, JP1
Kraemer, WJ2
Häkkinen, K1
Bonney, I1
Goudas, LC1
Shuster, L1
Achten, J1
Halson, SL1
Moseley, L1
Rayson, MP1
Casey, A1
Jeukendrup, AE1
Dratwa, M1
Wilkie, M1
Ryckelynck, JP1
ter Wee, PM1
Rutherford, P1
Michel, C1
Hopwood, A1
Curtis, L1
Denys, N1
Divino Filho, JC1
Faict, D1
Chen, PC1
Kohane, DS1
Park, YJ1
Bartlett, RH1
Langer, R1
Yang, VC1
Chatard, JC1
Atlaoui, D1
Farjanel, J1
Louisy, F1
Rastel, D1
Guézennec, CY1
Rosendal, L1
Larsson, B1
Kristiansen, J1
Peolsson, M1
Søgaard, K1
Kjær, M1
Sørensen, J1
Gerdle, B1
Wallman, KE1
Morton, AR1
Goodman, C1
Grove, R1
Lafaurie, M1
Dolivo, M1
Porcher, R1
Rudant, J1
Madelaine, I1
Molina, JM1
Christophersen, OA1
Haug, A1
Naves, LA1
McCleskey, EW2
Hinckson, EA1
Hopkins, WG1
Edwards, JS1
Pfitzinger, P1
Hellemans, J1
Al Malyan, M1
Becchi, C1
Nikkola, L1
Viitanen, P1
Boncinelli, S1
Chiellini, F1
Ashammakhi, N1
Desgorces, FD1
Sénégas, X1
Garcia, J1
Decker, L1
Noirez, P1
Sartorio, A1
Marinone, PG1
Agosti, F1
Van Hoecke, J1
Maffiuletti, NA1
Miyama, M1
Luís, AL1
Rodrigues, JM1
Geuna, S1
Amado, S1
Shirosaki, Y1
Lee, JM1
Fregnan, F1
Lopes, MA1
Veloso, AP1
Ferreira, AJ1
Santos, JD1
Armada-Da-silva, PA1
Varejão, AS1
Maurício, AC1
Yokota, T1
Wallensten, R1
Karlsson, J1
Mengshoel, AM1
Saugen, E1
Forre, O1
Vøllestad, NK1
Miles, MP1
Clarkson, PM2
Rosfors, S1
Celsing, F1
Eriksson, M1
Flynn, TW1
Connery, SM1
Smutok, MA1
Zeballos, RJ1
Weisman, IM1
Fletcher, D1
Le Corre, P1
Guilbaud, G1
Le Verge, R1
Cohen, O1
Steiner, I1
Argov, Z1
Ashkenazi, A1
Diment, J1
Saada, A1
River, Y1
Gleeson, M1
Blannin, AK1
Walsh, NP1
Field, CN1
Pritchard, JC1
Guinsburg, R1
Kopelman, BI1
Anand, KJ1
de Almeida, MF1
Peres, Cde A1
Miyoshi, MH1
De Letter, EA1
Piette, MH1
Okuda, T1
Wakita, K1
Tsuchiya, N1
Hatsuoka, K1
Koga, Y1
Kaetsu, I1
Sayers, SP1
Garry, MG1
Jackson, DL1
Geier, HE1
Southam, M1
Hargreaves, KM1
Riggs, JE1
Schochet, SS1
Webb, RW1
Lonne-Rahm, SB1
Fischer, T1
Berg, M1
Ross, G1
Grabill, J1
McDevitt, E1
Sutherland, SP1
Cook, SP1
Vetter, G1
Tegeder, I1
Coleman, WP1
Ikeda, Y1
Ueno, A1
Naraba, H1
Oh-ishi, S1
Volek, JS1
Rubin, MR1
Gómez, AL1
Ratamess, NA1
Gaynor, P1
Newton, M1
Sacco, P1
Takita, M1
Mikuni, M1
Takahashi, K1
Ljunggren, G2
Johansson, SE1
Berg, A1
Späth, M1
Rokitzki, L1
Staiger, J1
Keul, J1
Angelos, MG1
Whiteside, K1
Hamilton, GC1
Sinkeler, SP1
Wevers, RA1
Joosten, EM1
Binkhorst, RA1
Oei, LT1
Van't Hof, MA1
De Haan, AF1
Cannon, RO2
Leon, MB1
Watson, RM1
Rosing, DR1
Epstein, SE1
Borg, G1
Ceci, R1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"The Effect of Milnacipran or Placebo on Ventricular Lactate Levels and Fibromyalgia Induced Brain Fog."[NCT01108731]Phase 2/Phase 337 participants (Actual)Interventional2010-03-31Completed
Influence of Electrode Positioning and Current Type on Muscle Fatigability, Force Generation, Perceived Discomfort and Neuromuscular Adaptations Induced by Neuromuscular Electric Stimulation: Implications on Rehabilitation[NCT04200677]30 participants (Actual)Interventional2020-01-10Completed
Effects of Different Modalities of Medium and Low Frequency Electrical Stimulation in the Generation of Evoked Torque, Sensory Discomfort, Muscle Fatigue and Inheritance Peripheral Oxygen Supply in the Triceps Surae Muscle.[NCT05894044]44 participants (Anticipated)Interventional2023-05-23Recruiting
Oral 10% Dextrose Versus Sodium Dextrose Formula in Performance of Soccer Athlete. A Double-Blind Cross Over Randomized Controlled Trial[NCT04206579]30 participants (Actual)Interventional2019-03-25Completed
Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy.[NCT04073173]Phase 480 participants (Anticipated)Interventional2020-11-01Not yet recruiting
The Underlying Mechanisms From Exercise-induced Muscle Damage on Force Loss[NCT02125643]Phase 13 participants (Actual)Interventional2014-08-31Terminated (stopped due to Protocol was deem insufficient to answer research question)
Evaluation of Cilostazol in Combination With L-Carnitine in Subjects With Intermittent Claudication[NCT00822172]Phase 4164 participants (Actual)Interventional2008-09-30Completed
CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial[NCT03193294]151 participants (Actual)Interventional2016-11-07Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Ventricular Lactate Levels in the Brain

Ventricular lactate levels will be assessed before and at the end of the trial using a scanning method known as magnetic resonance spectroscopy (MRS), which is used to determine the presence and quantity of a number of chemicals in the brain. (NCT01108731)
Timeframe: Baseline and 2 months

Interventioninternational units (iu) (Mean)
Patients Taking the Drug Minalcipran-0.87
Patients Taking the Placebo0.32

Change in Widespread Pain

Pain was assessed using a visual analog scale (VAS) ranging from 0 (no pain) to 10 (worst pain ever). The baseline value recorded was widespread pain at the time of assessment and the 2 months follow value recorded was widespread pain over the week prior to assessment. (NCT01108731)
Timeframe: 2 months

Interventionunits on a scale (Mean)
Patients Taking the Drug Minalcipran-1.24
Patients Taking the Placebo0.66

Change in Cognitive Function Assessed by the no Cue Condition of the Attention Network Test (ANT).

The Attention Network Test (ANT) is a computerized test designed to evaluate the efficiency of the attention network. The ANT consists of a set of cued reaction time tasks to assess vigilance and efficiency to detect novel visual stimuli. The ANT also includes a set of flanker tasks during which a decision needs to be made about whether the orientation of a central stimulus is congruent or incongruent with a set of flanking arrows. Scores on the cued reaction time tasks (no cue, centre cue, double cue) reflect latency to respond measured in milliseconds (slower performance equals greater values). The score on the flanker task reflecting executive attention is derived by subtracting obtained latencies on the congruent flanker from the incongruent condition. Based on our prior work, we are hypothesizing that drug treated Ss will show improved performance on the no cue reaction time condition and on the derived executive attention variable compared to placebo treated. (NCT01108731)
Timeframe: Baseline and 2 months

,
Interventionlatency to respond (msecs.) (Mean)
No cue conditionExecutive attention
Patients Taking the Drug Minalcipran-79.56-68.73
Patients Taking the Placebo-35.00-34.77

Change From Baseline in Claudication Onset Time at Day 180

Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. The time during the conduct of the exercise treadmill test at which the subject first reported claudication symptoms is referred to as the claudication onset time (COT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180

InterventionLog Minutes (Mean)
Cilostazol + L-Carnitine1.065
Cilostazol + Placebo0.896

Change From Baseline in Claudication Onset Time at Day 90

Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. The time during the conduct of the exercise treadmill test at which the subject first reported claudication symptoms is referred to as the claudication onset time (COT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 90

InterventionLog Minutes (Mean)
Cilostazol + L-Carnitine1.001
Cilostazol + Placebo0.815

Change From Baseline in Peak Walking Time (PWT) at Day 180

Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180

InterventionLog Minutes (Mean)
Cilostazol + L-Carnitine0.241
Cilostazol + Placebo0.134

Change From Baseline in Peak Walking Time at Day 180

Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 180

InterventionLog Minutes (Mean)
Cilostazol + L-Carnitine0.267
Cilostazol + Placebo0.145

Change From Baseline in Peak Walking Time at Day 90

Subjects were asked to complete a standardized exercise treadmill test using a modified Gardner protocol. Subjects walked on the treadmill until they were physically unable to walk further either as a result of their peripheral artery disease (PAD) symptoms or other non-PAD symptoms. This maximum time walked is referred to as the peak walking time (PWT) and reported in minutes/seconds. The exercise treadmill test was conducted at Screening, Baseline, Day 90, and Day 180 visits. The log transformation is used to make highly skewed distributions less skewed. (NCT00822172)
Timeframe: Baseline, Day 90

InterventionLog Minutes (Mean)
Cilostazol + L-Carnitine0.166
Cilostazol + Placebo0.139

Change From Baseline in Walking Impairment Questionnaire for Walking Distance at Day 180

Subjects completed the Walking Impairment Questionnaire (WIQ) whereby they were asked about their maximal walking distance before having to rest as a result of claudication symptoms associated with their peripheral artery disease (PAD). The WIQ was administered at the Baseline, Day 90, and Day 180 visits. On the WIQ subjects were asked a series of questions related to their degree of physical difficulty that best described how hard it was for the subject to walk on level ground without stopping to rest. The questions began by asking the degree of difficulty walking around indoors, then 50 feet, 150 feet, 300 feet, 600 feet, 900 feet, and lastly 1500 feet. The responses range from None (best outcome) to Slight, then Some, then Much, then lastly Unable (worst outcome). The walking distance score was calculated from the 7 questions in the section by way of a weighted sum. A score of 100 indicated no walking impairment. A score of 0 corresponded to the highest degree of walking impairment (NCT00822172)
Timeframe: Baseline, Day 180

Interventionscore on a scale (Mean)
Cilostazol + L-Carnitine13.20
Cilostazol + Placebo6.57

Change From Baseline in Walking Impairment Questionnaire for Walking Distance at Day 90

Subjects completed the Walking Impairment Questionnaire (WIQ) whereby they were asked about their maximal walking distance before having to rest as a result of claudication symptoms associated with their peripheral artery disease (PAD). The WIQ was administered at the Baseline, Day 90, and Day 180 visits. On the WIQ subjects were asked a series of questions related to their degree of physical difficulty that best described how hard it was for the subject to walk on level ground without stopping to rest. The questions began by asking the degree of difficulty walking around indoors, then 50 feet, 150 feet, 300 feet, 600 feet, 900 feet, and lastly 1500 feet. The responses range from None (best outcome) to Slight, then Some, then Much, then lastly Unable (worst outcome). The walking distance score was calculated from the 7 questions in the section by way of a weighted sum. A score of 100 indicated no walking impairment. A score of 0 corresponded to the highest degree of walking impairment (NCT00822172)
Timeframe: Baseline, Day 90

Interventionscore on a scale (Mean)
Cilostazol + L-Carnitine12.98
Cilostazol + Placebo10.01

Reviews

11 reviews available for lactic acid and Pain

ArticleYear
[Maybe it hurts more than we think! Neonatal pain].
    Ideggyogyaszati szemle, 2014, Jul-30, Volume: 67, Issue:7-8

    Topics: Alanine; Animals; Blood Pressure; Fetus; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Lac

2014
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain.
    Biochimica et biophysica acta, 2015, Volume: 1848, Issue:10 Pt B

    Topics: Acid Sensing Ion Channels; Analgesics; Bone and Bones; Bone Neoplasms; Bone Resorption; Gene Express

2015
Caffeine and anaerobic performance: ergogenic value and mechanisms of action.
    Sports medicine (Auckland, N.Z.), 2009, Volume: 39, Issue:10

    Topics: Anaerobic Threshold; Bicycling; Blood Glucose; Caffeine; Catecholamines; Central Nervous System Stim

2009
Paucity of muscle metastasis in otherwise widely disseminated cancer: a conundrum.
    American journal of physical medicine & rehabilitation, 2010, Volume: 89, Issue:11

    Topics: Diagnostic Imaging; Edema; Humans; Lactic Acid; Muscle Neoplasms; Muscle, Skeletal; Neoplasm Metasta

2010
An acid-sensing ion channel that detects ischemic pain.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2005, Volume: 38, Issue:11

    Topics: Acid Sensing Ion Channels; Animals; Hydrogen-Ion Concentration; Ischemia; Lactic Acid; Membrane Prot

2005
Polymer-based biodegradable drug delivery systems in pain management.
    The Journal of craniofacial surgery, 2006, Volume: 17, Issue:2

    Topics: Absorbable Implants; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroida

2006
[Mechanism of anginal pain].
    Kokyu to junkan. Respiration & circulation, 1984, Volume: 32, Issue:4

    Topics: Angina Pectoris; Animals; Bradykinin; Cats; Coronary Vessels; Dogs; Humans; Ischemia; Lactates; Lact

1984
Exercise-induced muscle pain, soreness, and cramps.
    The Journal of sports medicine and physical fitness, 1994, Volume: 34, Issue:3

    Topics: Creatine Kinase; Exercise; Humans; Lactates; Lactic Acid; Muscle Contraction; Muscle Cramp; Muscle,

1994
Etiology of exercise-induced muscle damage.
    Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, 1999, Volume: 24, Issue:3

    Topics: Calcium; Carrier Proteins; Exercise; Glucose; Heat-Shock Proteins; Homeostasis; Humans; Hydrogen; La

1999
Chemical mediators of pain due to tissue damage and ischemia.
    Progress in brain research, 2000, Volume: 129

    Topics: Acetylcholine; Acid Sensing Ion Channels; Adenosine; Adenosine Triphosphate; Afferent Pathways; Anim

2000
Dermal peels.
    Dermatologic clinics, 2001, Volume: 19, Issue:3

    Topics: Chemexfoliation; Drug Combinations; Ethanol; Humans; Lactic Acid; Pain; Postoperative Care; Resorcin

2001

Trials

20 trials available for lactic acid and Pain

ArticleYear
Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial.
    International journal of dermatology, 2020, Volume: 59, Issue:7

    Topics: Acne Vulgaris; Adult; Chemexfoliation; Double-Blind Method; Drug Combinations; Ethanol; Facial Derma

2020
Images depicting human pain increase exercise-induced pain and impair endurance cycling performance.
    Journal of sports sciences, 2021, Volume: 39, Issue:2

    Topics: Adult; Bicycling; Female; Heart Rate; Humans; Lactic Acid; Male; Myalgia; Pain; Perception; Physical

2021
Carbohydrate Intake in Form of Gel Is Associated With Increased Gastrointestinal Distress but Not With Performance Differences Compared With Liquid Carbohydrate Ingestion During Simulated Long-Distance Triathlon.
    International journal of sport nutrition and exercise metabolism, 2016, Volume: 26, Issue:2

    Topics: Adult; Athletes; Athletic Performance; Beverages; Bicycling; Blood Glucose; Colic; Cross-Over Studie

2016
Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The journal of pain, 2015, Volume: 16, Issue:11

    Topics: Adrenergic Uptake Inhibitors; Adult; Anti-Inflammatory Agents, Non-Steroidal; Attention; Biomarkers;

2015
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:3

    Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid;

2010
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:3

    Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid;

2010
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:3

    Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid;

2010
Comparison between alternating and pulsed current electrical muscle stimulation for muscle and systemic acute responses.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:3

    Topics: Adult; Biomarkers; Electric Stimulation; Hormones; Humans; Isometric Contraction; Knee; Lactic Acid;

2010
Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Adiposity; Adult; Female; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Muscle, Skeletal; Muscu

2010
A nonischemic forearm exercise test for McArdle disease.
    Annals of neurology, 2002, Volume: 52, Issue:2

    Topics: Adult; Ammonia; Exercise; Exercise Test; Female; Forearm; Glycogen Storage Disease Type V; Hand Stre

2002
Release of algesic substances in human experimental muscle pain.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:8

    Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammatio

2002
Acute hormonal and neuromuscular responses and recovery to forced vs maximum repetitions multiple resistance exercises.
    International journal of sports medicine, 2003, Volume: 24, Issue:6

    Topics: Electromyography; Electrophysiology; Exercise; Hormones; Human Growth Hormone; Humans; Hydrocortison

2003
Higher dietary carbohydrate content during intensified running training results in better maintenance of performance and mood state.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:4

    Topics: Adult; Affect; Catecholamines; Cross-Over Studies; Dietary Carbohydrates; Dose-Response Relationship

2004
Clinical experience with two physiologic bicarbonate/lactate peritoneal dialysis solutions in automated peritoneal dialysis.
    Kidney international. Supplement, 2003, Issue:88

    Topics: Automation; Bicarbonates; Calcium; Dialysis Solutions; Gases; Humans; Lactic Acid; Pain; Patient Sat

2003
Elastic stockings, performance and leg pain recovery in 63-year-old sportsmen.
    European journal of applied physiology, 2004, Volume: 93, Issue:3

    Topics: Aged; Bandages; Bicycling; Exercise; Hematocrit; Humans; Lactic Acid; Leg; Male; Middle Aged; Pain;

2004
Treatment of facial lipoatrophy with intradermal injections of polylactic acid in HIV-infected patients.
    Journal of acquired immune deficiency syndromes (1999), 2005, Apr-01, Volume: 38, Issue:4

    Topics: Adult; Antiretroviral Therapy, Highly Active; Facial Dermatoses; Female; Follow-Up Studies; HIV Infe

2005
Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:1

    Topics: Adult; Creatine Kinase, MM Form; Electric Stimulation; Exercise; Human Growth Hormone; Humans; Isome

2008
Protection against muscle damage following fifty drop jumps conferred by ten drop jumps.
    Journal of strength and conditioning research, 2007, Volume: 21, Issue:4

    Topics: Athletic Injuries; Athletic Performance; Biomarkers; Creatine Kinase; Heart Rate; Humans; Knee; Lact

2007
Transcutaneous oxygen pressure measurements in patients with intermittent claudication.
    Clinical physiology (Oxford, England), 1994, Volume: 14, Issue:4

    Topics: Aged; Blood Gas Monitoring, Transcutaneous; Exercise Test; Heart Rate; Humans; Intermittent Claudica

1994
Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates.
    The Journal of pediatrics, 1998, Volume: 132, Issue:6

    Topics: Analgesia; Analgesics, Opioid; Blood Glucose; Catheterization, Central Venous; Double-Blind Method;

1998
Stinging and rosacea.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypersensitivity, Immediate; Lactic Acid; Male; Midd

1999
L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:2

    Topics: Adult; Biomarkers; Carnitine; Cross-Over Studies; Cytosol; Double-Blind Method; Exercise; Free Radic

2002
Muscle damage and soreness after endurance exercise of the elbow flexors.
    Medicine and science in sports and exercise, 2002, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Arm; Biomarkers; Creatine Kinase; Elbow; Exercise; Humans; Isometric Contraction;

2002

Other Studies

77 other studies available for lactic acid and Pain

ArticleYear
Glucocorticoid regulation of lactate release from spinal astrocytes contributes to the induction of spinal LTP of C-fiber-evoked field potentials and the development of mechanical allodynia.
    Neuropharmacology, 2022, 11-15, Volume: 219

    Topics: Animals; Astrocytes; Glucocorticoids; Hyperalgesia; Lactic Acid; Long-Term Potentiation; Mice; Pain;

2022
Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.
    Behavioural pharmacology, 2022, 12-01, Volume: 33, Issue:8

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Feeding Beh

2022
Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:4

    Topics: Capsaicin; Citrus; Fruit; Humans; Lactic Acid; Pain; Plant Extracts; Skin Diseases; TRPV Cation Chan

2023
Blood Flow Restricted Cycling Impairs Subsequent Jumping But Not Balance Performance Slightly More Than Non-Restricted Cycling: An Acute Randomized Controlled Cross-Over Trial.
    Journal of sports science & medicine, 2023, Volume: 22, Issue:1

    Topics: Bicycling; Cross-Over Studies; Female; Heart Rate; Humans; Lactic Acid; Pain; Young Adult

2023
Effects of fitness level and exercise intensity on pain and mood responses.
    European journal of pain (London, England), 2020, Volume: 24, Issue:3

    Topics: Adult; Affect; Exercise; Humans; Lactic Acid; Male; Pain; Pain Threshold; Physical Fitness; Young Ad

2020
Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles.
    Pharmaceutical research, 2017, Volume: 34, Issue:6

    Topics: Animals; Capsaicin; Cell Survival; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Fluo

2017
Relief of Pain-Depressed Behavior in Rats by Activation of D1-Like Dopamine Receptors.
    The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Benzazepines; Conditioning, Operant; Depression; Dopamine Ago

2017
Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation.
    Materials science & engineering. C, Materials for biological applications, 2017, Oct-01, Volume: 79

    Topics: Animals; Diclofenac; Lactic Acid; Pain; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolym

2017
Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain.
    Nanomedicine (London, England), 2017, Volume: 12, Issue:17

    Topics: Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dip

2017
A new tool to test active ingredient using lactic acid in vitro, a help to understand cellular mechanism involved in stinging test: An example using a bacterial polysaccharide (Fucogel
    Experimental dermatology, 2018, Volume: 27, Issue:3

    Topics: Acid Sensing Ion Channels; Adult; Aged; Animals; Carrier Proteins; Coculture Techniques; Female; Hum

2018
Hypoalgesia after bicycling at lactate threshold is reliable between sessions.
    European journal of applied physiology, 2019, Volume: 119, Issue:1

    Topics: Adult; Anaerobic Threshold; Bicycling; Female; Humans; Lactic Acid; Male; Muscle, Skeletal; Pain; Pa

2019
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
    Behavioural pharmacology, 2019, Volume: 30, Issue:6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamin

2019
Reduced burning and stinging associated with topical application of lactic acid 10% with strontium versus ammonium lactate 12%.
    Cutis, 2013, Volume: 91, Issue:5

    Topics: Administration, Cutaneous; Adult; Ammonium Hydroxide; Dermatologic Agents; Drug Combinations; Fatty

2013
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene E

2014
Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects.
    Experimental physiology, 2014, Volume: 99, Issue:2

    Topics: Adenosine Triphosphate; Adult; Exercise; Female; Humans; Lactic Acid; Male; Middle Aged; Muscle Fati

2014
No pain, no gain: somatosensation from skeletal muscle.
    Experimental physiology, 2014, Volume: 99, Issue:2

    Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S

2014
Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats.
    Behavioural pharmacology, 2014, Volume: 25, Issue:2

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Carbam

2014
Regional and seasonal differences in skin irritation and neurosensitivity in Chinese and South Korean women.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2015, Volume: 29, Issue:1

    Topics: Adult; Capsaicin; China; Dermatitis, Contact; Female; Healthy Volunteers; Humans; Lactic Acid; Pain;

2015
Feedback from group III/IV muscle afferents is not the sensory signal for perception of effort.
    Experimental physiology, 2014, May-01, Volume: 99, Issue:5

    Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S

2014
Reply: To PMID 24142455.
    Experimental physiology, 2014, May-01, Volume: 99, Issue:5

    Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Pain; S

2014
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:7

    Topics: Analgesics; Analgesics, Opioid; Animals; Delayed-Action Preparations; Ketamine; Lactic Acid; Male; M

2015
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
    Drug development research, 2015, Volume: 76, Issue:4

    Topics: Animals; Attention; Behavior, Animal; Edema; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Lactic A

2015
Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control.
    Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:3

    Topics: Acidosis; Aldehyde Dehydrogenase; Dichloroacetic Acid; Formaldehyde; Glutathione; Humans; Hydrogen-I

2015
Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Acid Sensing Ion Channels; Adenosine Triphosphate; Animals; Hydrogen-Ion Concentration; Hyperalgesia

2015
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Oct-21, Volume: 35, Issue:42

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Edema; Gene Expression Regulation; Hyperalgesia; I

2015
Electric shock causes physiological stress responses in shore crabs, consistent with prediction of pain.
    Biology letters, 2015, Volume: 11, Issue:11

    Topics: Animals; Behavior, Animal; Brachyura; Electric Stimulation; Hemolymph; Lactic Acid; Pain; Stress, Ph

2015
Sustained relief of pain from osteosynthesis surgery of rib fracture by using biodegradable lidocaine-eluting nanofibrous membranes.
    Nanomedicine : nanotechnology, biology, and medicine, 2016, Volume: 12, Issue:7

    Topics: Absorbable Implants; Anesthetics, Local; Animals; Lactic Acid; Lidocaine; Membranes, Artificial; Nan

2016
Blood parameters and electroencephalographic responses of goats to slaughter without stunning.
    Meat science, 2016, Volume: 121

    Topics: Abattoirs; Anesthesia; Animal Welfare; Animals; Blood Glucose; Calcium; Catecholamines; Consciousnes

2016
Cardiorespiratory Response to Different Exercise Tests in Interstitial Lung Disease.
    Medicine and science in sports and exercise, 2016, Volume: 48, Issue:12

    Topics: Dyspnea; Exercise Test; Exercise Tolerance; Female; Heart Rate; Humans; Lactic Acid; Leg; Lung Disea

2016
Exercise-induced hypoalgesia: Pain tolerance, preference and tolerance for exercise intensity, and physiological correlates following dynamic circuit resistance exercise.
    Journal of sports sciences, 2017, Volume: 35, Issue:18

    Topics: Exercise Tolerance; Female; Heart Rate; Humans; Lactic Acid; Male; Muscle Fatigue; Pain; Pain Thresh

2017
Load rather than contraction type influences rate of perceived exertion and pain.
    Journal of strength and conditioning research, 2008, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Heart Rate; Humans; Lactic Acid; Male; Muscle Contraction; Muscle, Skeletal; Pain

2008
Physiological responses and bowling performance during repeated spells of medium-fast bowling.
    Journal of sports sciences, 2009, Jan-01, Volume: 27, Issue:1

    Topics: Adult; Athletic Performance; Australia; Biophysics; Blood Glucose; Body Temperature; Body Weight; He

2009
[The role of hypoxic syndrome in pathogenesis of experimental stress-lesions].
    Klinichna khirurhiia, 2008, Issue:8

    Topics: Animals; Biomarkers; Disease Models, Animal; Hypoxia; Lactic Acid; Male; Oxygen; Pain; Pain Manageme

2008
Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic.
    Veterinary journal (London, England : 1997), 2010, Volume: 184, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Biomarkers; Blood Chemical Analysis; Case-Cont

2010
Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior.
    Pain, 2009, Volume: 144, Issue:1-2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Biophysics; Conditioning, Opera

2009
Emergency ambulance transport induces stress in patients with acute coronary syndrome.
    Emergency medicine journal : EMJ, 2009, Volume: 26, Issue:7

    Topics: Acute Coronary Syndrome; Aged; Ambulances; Blood Pressure; Epinephrine; Heart Rate; Humans; Lactic A

2009
Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats.
    International journal of pharmaceutics, 2009, Oct-01, Volume: 380, Issue:1-2

    Topics: Acupuncture Points; Animals; Bee Venoms; Biocompatible Materials; Delayed-Action Preparations; Drug

2009
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
    Psychopharmacology, 2010, Volume: 210, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug E

2010
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Jul-01, Volume: 145, Issue:1

    Topics: Animals; Brain; Drug Carriers; Glycopeptides; Lactic Acid; Loperamide; Male; Microscopy, Electron, S

2010
Poly(lactide-co-glycolide) nanocapsules containing benzocaine: influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity.
    Pharmaceutical research, 2011, Volume: 28, Issue:8

    Topics: Anesthetics, Local; Animals; Benzocaine; Cellulose; Chemistry, Pharmaceutical; Drug Carriers; Hydrog

2011
Quantitative study of stratum corneum ceramides contents in patients with sensitive skin.
    The Journal of dermatology, 2012, Volume: 39, Issue:3

    Topics: Adult; Back; Ceramides; Erythema; Face; Female; Forearm; Hand; Humans; Lactic Acid; Leg; Male; Pain;

2012
Dissociable effects of the cannabinoid receptor agonists Δ9-tetrahydrocannabinol and CP55940 on pain-stimulated versus pain-depressed behavior in rats.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cannabinoid R

2012
Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.
    The journal of pain, 2013, Volume: 14, Issue:3

    Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Biophysics; Conditioning, Operant; Depression;

2013
Hormonal responses to a resistance exercise performed under the influence of delayed onset muscle soreness.
    Journal of strength and conditioning research, 2002, Volume: 16, Issue:3

    Topics: Adult; Electromyography; Epinephrine; Exercise; Humans; Lactic Acid; Leg; Male; Muscle Fatigue; Musc

2002
Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats.
    Biomaterials, 2003, Volume: 24, Issue:11

    Topics: Analgesics; Animals; Bupivacaine; Drug Delivery Systems; Drug Implants; Enkephalins; Hydromorphone;

2003
RPE, pain, and physiological adjustment to concentric and eccentric contractions.
    Medicine and science in sports and exercise, 2003, Volume: 35, Issue:6

    Topics: Adolescent; Adult; Exercise; Heart Rate; Humans; Hydrocortisone; Lactic Acid; Male; Muscle Contracti

2003
In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems.
    Journal of biomaterials science. Polymer edition, 2003, Volume: 14, Issue:6

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Biocompatible Materials; Biodegra

2003
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
    Life sciences, 2003, Nov-14, Volume: 73, Issue:26

    Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug;

2003
Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects.
    Journal of biomedical materials research. Part A, 2004, Sep-01, Volume: 70, Issue:3

    Topics: Anesthetics, Local; Animals; Biocompatible Materials; Delayed-Action Preparations; Drug Carriers; Ge

2004
Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise.
    Pain, 2004, Volume: 112, Issue:3

    Topics: Creatine; Female; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Lactic Acid; Microdialysis; Muscle

2004
Physiological responses during a submaximal cycle test in chronic fatigue syndrome.
    Medicine and science in sports and exercise, 2004, Volume: 36, Issue:10

    Topics: Adult; Case-Control Studies; Exercise Test; Exercise Tolerance; Fatigue Syndrome, Chronic; Fear; Fem

2004
[About sugar, lactic acid and pain].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2005, Oct-20, Volume: 125, Issue:20

    Topics: Blood Glucose; Dietary Carbohydrates; Humans; Lactic Acid; Nerve Fibers, Myelinated; Pain; Receptors

2005
Sea-level performance in runners using altitude tents: a field study.
    Journal of science and medicine in sport, 2005, Volume: 8, Issue:4

    Topics: Adult; Altitude; Camping; Case-Control Studies; Equipment and Supplies; Exercise Test; Fatigue; Fema

2005
Methods to quantify intermittent exercises.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2007, Volume: 32, Issue:4

    Topics: Adult; Exercise; Heart Rate; Humans; Lactic Acid; Male; Models, Biological; Muscle Strength; Muscle,

2007
Use of PLGA 90:10 scaffolds enriched with in vitro-differentiated neural cells for repairing rat sciatic nerve defects.
    Tissue engineering. Part A, 2008, Volume: 14, Issue:6

    Topics: Animals; Biomechanical Phenomena; Cell Differentiation; Cell Line, Tumor; Hydrogen-Ion Concentration

2008
Histochemical and metabolic changes in lower leg muscles in exercise-induced pain.
    International journal of sports medicine, 1984, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Biopsy, Needle; Humans; Lactates; Lactic Acid; Leg; Male; Muscles; Pain; Physical

1984
Muscle fatigue in early fibromyalgia.
    The Journal of rheumatology, 1995, Volume: 22, Issue:1

    Topics: Adult; Catecholamines; Electromyography; Exercise; Female; Fibromyalgia; Humans; Lactates; Lactic Ac

1995
Comparison of cardiopulmonary responses to forward and backward walking and running.
    Medicine and science in sports and exercise, 1994, Volume: 26, Issue:1

    Topics: Athletic Injuries; Gait; Heart Rate; Humans; Knee Injuries; Lactates; Lactic Acid; Male; Oxygen Cons

1994
Antinociceptive effect of bupivacaine encapsulated in poly(D,L)-lactide-co-glycolide microspheres in the acute inflammatory pain model of carrageenin-injected rats.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: Acute Disease; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Drug Compounding; Inflammation

1997
Mitochondrial myopathy with atypical subacute presentation.
    Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:3

    Topics: Acute Disease; Adult; Biopsy; Disease Progression; Electromyography; Female; Humans; Lactic Acid; Mi

1998
Effect of exercise-induced muscle damage on the blood lactate response to incremental exercise in humans.
    European journal of applied physiology and occupational physiology, 1998, Volume: 77, Issue:3

    Topics: Adult; Bicycling; Creatine Kinase; Exercise; Female; Humans; Lactic Acid; Male; Muscle Weakness; Mus

1998
Can routinely combined analysis of glucose and lactate in vitreous humour be useful in current forensic practice?
    The American journal of forensic medicine and pathology, 1998, Volume: 19, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Cause of Death; Child; Forensic Medicine; Glucose; Humans; Lactic Ac

1998
[Prolonged antinociceptive effect of poly (DL-lactic acid)-fentanyl composites after their intrathecal injection in rats].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:2

    Topics: Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Carriers; Fentanyl; Injections, Spina

1999
Evaluation of the efficacy of a bioerodible bupivacaine polymer system on antinociception and inflammatory mediator release.
    Pain, 1999, Volume: 82, Issue:1

    Topics: Anesthetics, Local; Animals; Biocompatible Materials; Biodegradation, Environmental; Bradykinin; Bup

1999
Exertional myalgia syndrome associated with diminished serum ammonia elevation in ischemic exercise testing.
    Military medicine, 1999, Volume: 164, Issue:9

    Topics: Adult; Ammonia; AMP Deaminase; Biopsy; Chronic Disease; Exercise Test; Humans; Lactic Acid; Male; Mu

1999
Chondral injury after meniscal repair with bioabsorbable arrows.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2000, Volume: 16, Issue:7

    Topics: Absorbable Implants; Adult; Arthroscopy; Cartilage, Articular; Femur; Humans; Knee Joint; Lactic Aci

2000
Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Animals; Dinoprostone; Glutamic Acid; Glycerol; Lactic Acid; Male; Microdialysis; Nitrates; Nitric O

2001
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
    Life sciences, 2001, Nov-02, Volume: 69, Issue:24

    Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B

2001
Assessment of biodegradable controlled release rod systems for pain relief applications.
    Journal of biomaterials science. Polymer edition, 2002, Volume: 13, Issue:1

    Topics: Analgesics, Opioid; Biocompatible Materials; Biodegradation, Environmental; Codeine; Drug Delivery S

2002
Habituation of lactate release responding to stressful stimuli in rat prefrontal cortex in vivo.
    The American journal of physiology, 1992, Volume: 263, Issue:3 Pt 2

    Topics: Acoustic Stimulation; Animals; Brain; Diagnosis, Computer-Assisted; Dialysis; Dopamine; Extracellula

1992
Use of submaximal measures of perceived exertion during bicycle ergometer exercise as predictors of maximal work capacity.
    Journal of sports sciences, 1988,Winter, Volume: 6, Issue:3

    Topics: Adult; Exercise Test; Heart Rate; Humans; Lactates; Lactic Acid; Male; Pain; Perception; Physical Ex

1988
Influence of symptom-limited stress on blood lactate behaviour in coronary heart disease (CHD) patients.
    European heart journal, 1987, Volume: 8 Suppl G

    Topics: Aged; Exercise Test; Heart Rate; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardial Infarc

1987
Abdominal pain and weakness in an elderly woman.
    Annals of emergency medicine, 1986, Volume: 15, Issue:10

    Topics: Abdomen; Aged; Creatine Kinase; Electrocardiography; Female; Heart Failure; Humans; Isoenzymes; Lact

1986
Improvement of screening in exertional myalgia with a standardized ischemic forearm test.
    Muscle & nerve, 1986, Volume: 9, Issue:8

    Topics: Adolescent; Adult; Aged; Ammonia; AMP Deaminase; Child; Child, Preschool; Clinical Enzyme Tests; Fem

1986
Chest pain and "normal" coronary arteries--role of small coronary arteries.
    The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3

    Topics: Adult; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Electrocardiography; Ergonovine;

1985
Myocardial ischemia due to dynamic small vessel coronary artery disease.
    International journal of cardiology, 1985, Volume: 7, Issue:2

    Topics: Animals; Cardiac Pacing, Artificial; Cold Temperature; Coronary Circulation; Coronary Disease; Coron

1985
The increase of perceived exertion, aches and pain in the legs, heart rate and blood lactate during exercise on a bicycle ergometer.
    European journal of applied physiology and occupational physiology, 1985, Volume: 54, Issue:4

    Topics: Adult; Bicycling; Heart Rate; Humans; Lactates; Lactic Acid; Leg; Male; Pain; Perception; Physical E

1985