hydrogen has been researched along with Sepsis in 47 studies
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.
dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Molecular hydrogen treatment promotes functional outcomes after SAE in mice, which may be attributable to increasing beneficial bacteria, repressing harmful bacteria, and metabolic disorder, and reducing inflammation." | 9.69 | Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota. ( Bai, Y; Chen, H; Dong, B; Han, Q; Li, Y; Luo, N; Yu, Y; Zhou, C, 2023) |
| "Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP)." | 8.91 | Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. ( Dai, Q; Fan, Y; Huang, X; Zhai, Y; Zhou, X, 2015) |
| "Rats were challenged with lipopolysaccharide (LPS) at a dose of 8 mg/kg injected intraperitoneally to induce sepsis and hydrogen-rich saline (HRS) administered 1 h following LPS induction at a dose of 5 ml/kg." | 8.12 | Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy. ( Chen, Y; Du, J; Dumbuya, JS; Li, S; Liang, L; Zeng, Q, 2022) |
| "These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury." | 8.02 | Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy. ( Chen, H; Dong, B; Lin, H; Wang, Y; Xie, K; Yu, Y, 2021) |
| "Hydrogen provided protection from organ injury induced by sepsis via autophagy activation and endoplasmic reticulum stress pathway inactivation." | 7.96 | Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research. ( Chen, HG; Han, HZ; Li, Y; Xie, KL; Yu, YH, 2020) |
| " In this study, we focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine model of sepsis." | 7.88 | Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. ( Hirano, SI; Ichimaru, N; Ikeda, M; Kurakawa, T; Motooka, D; Nakamura, S; Ogura, H; Shimazu, T; Shimizu, K; Takahara, S; Takeda, K; Umemoto, E, 2018) |
| "To investigate the role of Rho/ROCK signaling pathway in the protective effects of hydrogen gas (H2) on acute lung injury (ALI) in a mouse model of sepsis." | 7.83 | [Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice]. ( Liang, Y; Liu, L; Sun, Z; Yu, Y; Zhang, H, 2016) |
| "176 male ICR mice were randomly divided into four groups: sham operation group, hydrogen control group (sham+hydrogen inhalation), model group (severe sepsis model) and hydrogen treatment group (severe sepsis model+hydrogen inhalation), with 44 mice in each group." | 7.81 | [Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with severe sepsis]. ( Hu, N; Ma, X; Wang, G; Yang, T; Yu, Y; Zhang, H, 2015) |
| "Hydrogen gas (H2) has antioxidative, anti-inflammatory, and antiapoptotic effects and may have beneficial effects in severe sepsis." | 7.81 | Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1. ( Chen, H; Li, Q; Li, Y; Liu, L; Wang, G; Wang, T; Xie, K; Yu, Y, 2015) |
| "152 male ICR mice were randomly divided into four groups: sham operation group, hydrogen control group, sepsis group, and hydrogen treatment group, each n=38." | 7.80 | [The role of Nrf2 in the hydrogen treatment for intestinal injury caused by severe sepsis]. ( Chen, H; Li, Y; Wang, G; Wang, W; Xie, K; Yu, Y, 2014) |
| "Sepsis is the main cause of death in critically ill patients with no effective treatment." | 6.72 | Perspective of Molecular Hydrogen in the Treatment of Sepsis. ( Qi, B; Wang, Y; Xie, K; Yu, Y, 2021) |
| "Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment." | 6.61 | Recent Advances in Studies of Molecular Hydrogen against Sepsis. ( Liu, Y; Qiu, P; Zhang, J, 2019) |
| "Sepsis is characterized by a severe inflammatory response to infection." | 6.50 | Hydrogen gas presents a promising therapeutic strategy for sepsis. ( Liu, L; Wang, G; Xie, K; Yu, Y, 2014) |
| "Hydrogen plays a protective role in different diseases; however, the detailed mechanism of hydrogen-treated disease remains unclear." | 5.91 | Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression. ( Bao, J; Chen, J; Lai, K; Li, L; Wu, H; Xie, K; Yang, X; Yu, Y; Zhang, Y, 2023) |
| "Molecular hydrogen treatment promotes functional outcomes after SAE in mice, which may be attributable to increasing beneficial bacteria, repressing harmful bacteria, and metabolic disorder, and reducing inflammation." | 5.69 | Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota. ( Bai, Y; Chen, H; Dong, B; Han, Q; Li, Y; Luo, N; Yu, Y; Zhou, C, 2023) |
| "Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice." | 5.62 | Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. ( Chen, H; Mao, X; Wang, G; Wang, Y; Xie, K; Yin, L, 2021) |
| "Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments." | 5.62 | Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis. ( Egi, H; Hattori, M; Ide, K; Ohdan, H; Oue, N; Sada, H; Sawada, H; Sentani, K; Sumi, Y; Yasui, W, 2021) |
| "Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells." | 5.56 | Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. ( Jiang, Y; Lu, Y; Lv, G; Su, L; Wang, Y; Xie, K; Yu, Y; Zhao, S; Zhuang, X, 2020) |
| "Sepsis is a highly heterogeneous syndrome that is caused by a dysregulated host response to infection." | 5.51 | Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis. ( Chen, H; Feng, J; Li, Y; Mao, X; Meng, X; Wang, Y; Xie, K; Yu, Y; Zhang, L; Zhang, Y, 2019) |
| "Hydrogen has been reported to selectively reduce hydroxyl radicals and peroxynitrite anion in many pathologic processes." | 5.39 | Effects of hydrogen-rich saline treatment on polymicrobial sepsis. ( Fan, YX; Ji, MH; Li, GM; Li, N; Li, WY; Sun, XJ; Tian, M; Yang, JJ; Zeng, QT, 2013) |
| "Sepsis is the most common cause of death in intensive care units." | 5.38 | Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. ( Chen, H; Fu, W; Han, H; Li, A; Wang, G; Xie, K; Xing, W; Yu, Y, 2012) |
| "Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction." | 5.38 | Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. ( Bai, YP; Chen, Y; Huang, GQ; Li, J; Liu, L; Wang, J; Wu, GM; Zhou, J, 2012) |
| "Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP)." | 4.91 | Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. ( Dai, Q; Fan, Y; Huang, X; Zhai, Y; Zhou, X, 2015) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Rats were challenged with lipopolysaccharide (LPS) at a dose of 8 mg/kg injected intraperitoneally to induce sepsis and hydrogen-rich saline (HRS) administered 1 h following LPS induction at a dose of 5 ml/kg." | 4.12 | Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy. ( Chen, Y; Du, J; Dumbuya, JS; Li, S; Liang, L; Zeng, Q, 2022) |
| "These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury." | 4.02 | Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy. ( Chen, H; Dong, B; Lin, H; Wang, Y; Xie, K; Yu, Y, 2021) |
| "Hydrogen provided protection from organ injury induced by sepsis via autophagy activation and endoplasmic reticulum stress pathway inactivation." | 3.96 | Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research. ( Chen, HG; Han, HZ; Li, Y; Xie, KL; Yu, YH, 2020) |
| " In this study, we focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine model of sepsis." | 3.88 | Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. ( Hirano, SI; Ichimaru, N; Ikeda, M; Kurakawa, T; Motooka, D; Nakamura, S; Ogura, H; Shimazu, T; Shimizu, K; Takahara, S; Takeda, K; Umemoto, E, 2018) |
| "To investigate the role of Rho/ROCK signaling pathway in the protective effects of hydrogen gas (H2) on acute lung injury (ALI) in a mouse model of sepsis." | 3.83 | [Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice]. ( Liang, Y; Liu, L; Sun, Z; Yu, Y; Zhang, H, 2016) |
| "Hydrogen gas (H2) has antioxidative, anti-inflammatory, and antiapoptotic effects and may have beneficial effects in severe sepsis." | 3.81 | Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1. ( Chen, H; Li, Q; Li, Y; Liu, L; Wang, G; Wang, T; Xie, K; Yu, Y, 2015) |
| "176 male ICR mice were randomly divided into four groups: sham operation group, hydrogen control group (sham+hydrogen inhalation), model group (severe sepsis model) and hydrogen treatment group (severe sepsis model+hydrogen inhalation), with 44 mice in each group." | 3.81 | [Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with severe sepsis]. ( Hu, N; Ma, X; Wang, G; Yang, T; Yu, Y; Zhang, H, 2015) |
| "Compared with the sham operation and hydrogen control groups, in the sepsis group, the number of normal pyramidal neurons in the hippocampal CA1 region was markedly reduced, the apoptotic index was marked increased, the expressions of nucleus and total Nrf2 were partly increased, the activities of SOD and CAT in the hippocampus were significantly decreased, and the levels of MDA and 8-iso-PGF2α were markedly increased, the escape latency at day 4 to 8 after operation was significantly extended, and there was no difference in swimming speed, the percentage of time in the target quadrant and the times of the platform crossing were significantly decreased on probe day." | 3.80 | [Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice]. ( Chen, H; Dong, X; Liu, L; Wang, G; Xie, K; Yu, Y, 2014) |
| "152 male ICR mice were randomly divided into four groups: sham operation group, hydrogen control group, sepsis group, and hydrogen treatment group, each n=38." | 3.80 | [The role of Nrf2 in the hydrogen treatment for intestinal injury caused by severe sepsis]. ( Chen, H; Li, Y; Wang, G; Wang, W; Xie, K; Yu, Y, 2014) |
| " Hydrogen gas treatment increased the 7-d survival rate of severe CLP mice to 60 % (Compared with severe sepsis group, P <0." | 3.76 | [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. ( Hou, LC; Wang, GL; Xie, KL; Xiong, LZ, 2010) |
| "Sepsis is the main cause of death in critically ill patients with no effective treatment." | 2.72 | Perspective of Molecular Hydrogen in the Treatment of Sepsis. ( Qi, B; Wang, Y; Xie, K; Yu, Y, 2021) |
| "Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment." | 2.61 | Recent Advances in Studies of Molecular Hydrogen against Sepsis. ( Liu, Y; Qiu, P; Zhang, J, 2019) |
| "Sepsis is characterized by a severe inflammatory response to infection." | 2.50 | Hydrogen gas presents a promising therapeutic strategy for sepsis. ( Liu, L; Wang, G; Xie, K; Yu, Y, 2014) |
| "Hydrogen plays a protective role in different diseases; however, the detailed mechanism of hydrogen-treated disease remains unclear." | 1.91 | Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression. ( Bao, J; Chen, J; Lai, K; Li, L; Wu, H; Xie, K; Yang, X; Yu, Y; Zhang, Y, 2023) |
| "Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection." | 1.72 | Hydrogen-rich medium ameliorates lipopolysaccharides-induced mitochondrial fission and dysfunction in human umbilical vein endothelial cells (HUVECs) via up-regulating HO-1 expression. ( Chen, H; Lian, N; Mao, X; Su, Y; Wang, Y; Xie, K; Yu, Y; Zhu, R, 2022) |
| "Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice." | 1.62 | Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. ( Chen, H; Mao, X; Wang, G; Wang, Y; Xie, K; Yin, L, 2021) |
| "Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments." | 1.62 | Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis. ( Egi, H; Hattori, M; Ide, K; Ohdan, H; Oue, N; Sada, H; Sawada, H; Sentani, K; Sumi, Y; Yasui, W, 2021) |
| "Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells." | 1.56 | Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. ( Jiang, Y; Lu, Y; Lv, G; Su, L; Wang, Y; Xie, K; Yu, Y; Zhao, S; Zhuang, X, 2020) |
| "Sepsis is a highly heterogeneous syndrome that is caused by a dysregulated host response to infection." | 1.51 | Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis. ( Chen, H; Feng, J; Li, Y; Mao, X; Meng, X; Wang, Y; Xie, K; Yu, Y; Zhang, L; Zhang, Y, 2019) |
| "Sepsis is common in intensive care units (ICU) and is associated with high mortality." | 1.42 | Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation. ( Liu, L; Tao, B; Tong, D; Wang, N; Wang, W; Zhang, J, 2015) |
| "Hydrogen gas (H2) is effective for treating sepsis." | 1.42 | Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. ( Chen, H; Li, Y; Wang, G; Xie, K; Yu, Y, 2015) |
| "Hydrogen has been reported to selectively reduce hydroxyl radicals and peroxynitrite anion in many pathologic processes." | 1.39 | Effects of hydrogen-rich saline treatment on polymicrobial sepsis. ( Fan, YX; Ji, MH; Li, GM; Li, N; Li, WY; Sun, XJ; Tian, M; Yang, JJ; Zeng, QT, 2013) |
| "Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction." | 1.38 | Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. ( Bai, YP; Chen, Y; Huang, GQ; Li, J; Liu, L; Wang, J; Wu, GM; Zhou, J, 2012) |
| "Sepsis is the most common cause of death in intensive care units." | 1.38 | Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. ( Chen, H; Fu, W; Han, H; Li, A; Wang, G; Xie, K; Xing, W; Yu, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.13) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.13) | 29.6817 |
| 2010's | 27 (57.45) | 24.3611 |
| 2020's | 18 (38.30) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 4 |
| Zhang, J | 5 |
| Fu, Z | 1 |
| Lian, N | 1 |
| Mao, X | 3 |
| Su, Y | 1 |
| Wang, Y | 11 |
| Chen, H | 17 |
| Zhu, R | 1 |
| Yu, Y | 30 |
| Xie, K | 22 |
| Dumbuya, JS | 4 |
| Li, S | 5 |
| Liang, L | 4 |
| Chen, Y | 4 |
| Du, J | 4 |
| Zeng, Q | 4 |
| Han, Q | 3 |
| Bai, Y | 3 |
| Zhou, C | 3 |
| Dong, B | 4 |
| Li, Y | 12 |
| Luo, N | 3 |
| Qi, B | 2 |
| Song, Y | 2 |
| Chen, C | 2 |
| Zhao, L | 1 |
| Ma, W | 1 |
| Meng, S | 1 |
| Zhuang, X | 2 |
| Lin, H | 2 |
| Liang, J | 1 |
| Cui, Y | 1 |
| Chen, J | 1 |
| Wu, H | 1 |
| Li, L | 1 |
| Yang, X | 1 |
| Lai, K | 1 |
| Bao, J | 1 |
| Fan, Y | 2 |
| Jiang, Y | 2 |
| Wang, E | 1 |
| Xu, F | 1 |
| Chen, X | 1 |
| Xie, H | 1 |
| Meng, X | 1 |
| Feng, J | 1 |
| Zhang, L | 1 |
| Chen, HG | 1 |
| Han, HZ | 1 |
| Yu, YH | 1 |
| Xie, KL | 2 |
| Yao, W | 1 |
| Guo, A | 1 |
| Han, X | 1 |
| Wu, S | 1 |
| Luo, C | 1 |
| Li, H | 1 |
| Hei, Z | 1 |
| Zhao, S | 1 |
| Su, L | 1 |
| Lu, Y | 1 |
| Lv, G | 1 |
| Dong, A | 1 |
| Jesus, AA | 1 |
| Passaglia, P | 1 |
| Santos, BM | 1 |
| Rodrigues-Santos, I | 1 |
| Flores, RA | 1 |
| Batalhão, ME | 1 |
| Stabile, AM | 1 |
| Cárnio, EC | 1 |
| Yin, L | 1 |
| Wang, G | 12 |
| Matsuura, H | 1 |
| Matsumoto, H | 1 |
| Okuzaki, D | 1 |
| Shimizu, K | 2 |
| Ogura, H | 2 |
| Ebihara, T | 1 |
| Matsubara, T | 1 |
| Hirano, SI | 2 |
| Shimazu, T | 2 |
| Sada, H | 1 |
| Egi, H | 1 |
| Ide, K | 1 |
| Sawada, H | 1 |
| Sumi, Y | 1 |
| Hattori, M | 1 |
| Sentani, K | 1 |
| Oue, N | 1 |
| Yasui, W | 1 |
| Ohdan, H | 1 |
| Bian, Y | 2 |
| Qin, C | 1 |
| Xin, Y | 1 |
| Ikeda, M | 1 |
| Kurakawa, T | 1 |
| Umemoto, E | 1 |
| Motooka, D | 1 |
| Nakamura, S | 1 |
| Ichimaru, N | 1 |
| Takeda, K | 1 |
| Takahara, S | 1 |
| Zhang, H | 4 |
| Liu, L | 11 |
| Sun, Z | 1 |
| Liang, Y | 1 |
| Qiu, P | 1 |
| Liu, Y | 1 |
| Wang, W | 3 |
| Dong, X | 2 |
| Liu, H | 1 |
| Liang, X | 1 |
| Wang, D | 1 |
| Duan, Q | 1 |
| Zhai, Y | 1 |
| Zhou, X | 1 |
| Dai, Q | 1 |
| Huang, X | 1 |
| Li, Q | 1 |
| Wang, T | 1 |
| Ma, X | 1 |
| Yang, T | 2 |
| Hu, N | 1 |
| Han, H | 2 |
| Tao, B | 2 |
| Wang, N | 3 |
| Tong, D | 1 |
| Liu, LD | 1 |
| Wu, XY | 1 |
| Tao, BD | 1 |
| Jiang, J | 1 |
| Zheng, Y | 1 |
| Zhu, D | 1 |
| Iketani, M | 1 |
| Ohshiro, J | 1 |
| Urushibara, T | 1 |
| Takahashi, M | 1 |
| Arai, T | 1 |
| Kawaguchi, H | 1 |
| Ohsawa, I | 1 |
| Yang, Y | 1 |
| Pei, Y | 1 |
| Hou, L | 1 |
| Chen, S | 1 |
| Xiong, L | 1 |
| Hou, LC | 1 |
| Wang, GL | 1 |
| Xiong, LZ | 1 |
| Zhou, J | 1 |
| Huang, GQ | 1 |
| Li, J | 1 |
| Wu, GM | 1 |
| Bai, YP | 1 |
| Wang, J | 1 |
| Li, GM | 1 |
| Ji, MH | 1 |
| Sun, XJ | 1 |
| Zeng, QT | 1 |
| Tian, M | 1 |
| Fan, YX | 1 |
| Li, WY | 1 |
| Li, N | 1 |
| Yang, JJ | 1 |
| Fu, W | 1 |
| Xing, W | 1 |
| Li, A | 1 |
| Ball, J | 1 |
| Schoenenberger, GA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care. Double-blind, Randomized, Comparative Study[NCT04716985] | 700 participants (Actual) | Interventional | 2021-01-22 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for hydrogen and Sepsis
| Article | Year |
|---|---|
Molecular hydrogen is a potential protective agent in the management of acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; COVID-19 Drug Treatment; Humans | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Perspective of Molecular Hydrogen in the Treatment of Sepsis.
Topics: Anti-Inflammatory Agents; Autophagy; Cell Death; Humans; Hydrogen; Sepsis | 2021 |
Recent Advances in Studies of Molecular Hydrogen against Sepsis.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Autophagy; Hydrogen; Liver; Protective Agents; Se | 2019 |
Hydrogen gas presents a promising therapeutic strategy for sepsis.
Topics: Animals; Humans; Hydrogen; Sepsis; Sodium Chloride | 2014 |
Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Cecum; Disease Models, Animal; D | 2015 |
Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.
Topics: Animals; Humans; Hydrogen; Multiple Organ Failure; Organ Specificity; Oxidative Stress; Sepsis; Trea | 2016 |
Burn toxins isolated from mouse and human skin. Their characterization and immunotherapy effects.
Topics: Animals; Antitoxins; Biological Assay; Burns; Carbon; Centrifugation, Density Gradient; Chromatograp | 1975 |
2 trials available for hydrogen and Sepsis
| Article | Year |
|---|---|
Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
Topics: Animals; Brain; Gastrointestinal Microbiome; Hydrogen; Inflammation; Male; Mice; Sepsis; Sepsis-Asso | 2023 |
Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
Topics: Animals; Brain; Gastrointestinal Microbiome; Hydrogen; Inflammation; Male; Mice; Sepsis; Sepsis-Asso | 2023 |
Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
Topics: Animals; Brain; Gastrointestinal Microbiome; Hydrogen; Inflammation; Male; Mice; Sepsis; Sepsis-Asso | 2023 |
Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
Topics: Animals; Brain; Gastrointestinal Microbiome; Hydrogen; Inflammation; Male; Mice; Sepsis; Sepsis-Asso | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
38 other studies available for hydrogen and Sepsis
| Article | Year |
|---|---|
Hydrogen-rich medium ameliorates lipopolysaccharides-induced mitochondrial fission and dysfunction in human umbilical vein endothelial cells (HUVECs) via up-regulating HO-1 expression.
Topics: Adenosine Triphosphate; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen; | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
Topics: Animals; Hydrogen; Lipopolysaccharides; Mitochondria; Neuroinflammatory Diseases; Quality of Life; R | 2022 |
Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Hydrogen; Male; Mice; Mice, Inbred C57BL; Neurodegenera | 2023 |
Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression.
Topics: Animals; Heme Oxygenase-1; Hydrogen; Lipopolysaccharides; Mice; Microglia; NF-E2-Related Factor 2; P | 2023 |
APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis.
Topics: Animals; Apolipoprotein A-II; Biomarkers; Diabetes Mellitus, Type 2; Genetic Predisposition to Disea | 2023 |
Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.
Topics: Animals; Caspase 1; Child; Humans; Hydrogen; Inflammasomes; Lipopolysaccharides; Neuroinflammatory D | 2023 |
Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis.
Topics: Animals; Autophagy; Cytokines; Hydrogen; Inflammasomes; Inflammation Mediators; Lipopolysaccharides; | 2019 |
Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research.
Topics: Animals; Autophagy; Disease Models, Animal; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stre | 2020 |
Aerosol inhalation of a hydrogen-rich solution restored septic renal function.
Topics: Acute Kidney Injury; Administration, Inhalation; Animals; Cytokines; Drug Evaluation, Preclinical; H | 2019 |
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Cell Differentiation; Cell Line; Humans; Hydrogen; Mal | 2020 |
Protective Effects of Hydrogen on Myocardial Mitochondrial Functions in Septic Mice.
Topics: Animals; Disease Models, Animal; Heme Oxygenase-1; Hydrogen; Male; Membrane Proteins; Mice; Mice, Kn | 2020 |
Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
Topics: Administration, Inhalation; Animals; Antioxidants; Apoptosis; Brain; Disease Models, Animal; Hippoca | 2020 |
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
Topics: Animals; Brain Injuries; Disease Models, Animal; DNA-Binding Proteins; High Mobility Group Proteins; | 2021 |
Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Humans; Hydrogen; Male; Mice; RNA-Seq; | 2021 |
Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis.
Topics: Acute Disease; Animals; Antioxidants; Disease Models, Animal; Free Radical Scavengers; Hydrogen; Mal | 2021 |
Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy.
Topics: Acute Lung Injury; Animals; Autophagy; Cell Line; Hydrogen; Inflammation; Lipopolysaccharides; Lung; | 2021 |
Itraq-Based Quantitative Proteomic Analysis of Lungs in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
Topics: Animals; Hydrogen; Lung; Male; Mice; Mice, Inbred ICR; Proteomics; Sepsis | 2018 |
Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
Topics: Animals; Bacterial Translocation; Disease Models, Animal; Dysbiosis; Enterobacteriaceae; Hydrogen; I | 2018 |
[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Hydrogen; Inflamma | 2016 |
[The role of Nrf2 in the hydrogen treatment for intestinal injury caused by severe sepsis].
Topics: Animals; Disease Models, Animal; HMGB1 Protein; Hydrogen; Intestinal Mucosa; Intestines; Male; Mice; | 2014 |
[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].
Topics: Animals; Brain; Dinoprost; Disease Models, Animal; Hydrogen; Male; Malondialdehyde; Mice; Mice, Inbr | 2014 |
Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis.
Topics: Administration, Inhalation; Animals; Apoptosis; Brain Injuries; Cecum; Conditioning, Psychological; | 2014 |
Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, An | 2015 |
Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1.
Topics: Animals; Heme Oxygenase-1; HMGB1 Protein; Hydrogen; Lung; Male; Membrane Proteins; Mice; NF-E2-Relat | 2015 |
Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1.
Topics: Animals; Gene Expression Regulation; Heme Oxygenase-1; Hydrogen; Intestines; Male; Membrane Proteins | 2015 |
[Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with severe sepsis].
Topics: Animals; Caspase 3; HMGB1 Protein; Hydrogen; Interleukin-6; Intestines; Male; Mice; Mice, Inbred ICR | 2015 |
Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Disease Models, Animal; Dose-Response Relation | 2015 |
Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation.
Topics: Adenosine Triphosphate; Animals; Echocardiography; Fatty Acids; Heart; Heart Diseases; Heart Ventric | 2015 |
Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis.
Topics: Acute Lung Injury; Animals; Aquaporin 1; Epithelial Cells; Gene Expression Regulation; Hydrogen; Mal | 2016 |
Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs.
Topics: Animals; Aquaporin 1; Aquaporin 5; Biomarkers; Blotting, Western; Down-Regulation; Hydrogen; Injecti | 2016 |
Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hydrogen; In Situ Nick-End | 2017 |
Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
Topics: Animals; Heme Oxygenase-1; HMGB1 Protein; Hydrogen; Intestinal Diseases; Intestinal Mucosa; Intestin | 2017 |
Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
Topics: Administration, Inhalation; Animals; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Hydrogen; Lun | 2010 |
[Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice].
Topics: Administration, Inhalation; Animals; Disease Models, Animal; HMGB1 Protein; Hydrogen; Male; Mice; Mi | 2010 |
Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture.
Topics: Animals; Caspase 3; Cecum; Cognition Disorders; Disease Models, Animal; Hippocampus; Hydrogen; Ligat | 2012 |
Effects of hydrogen-rich saline treatment on polymicrobial sepsis.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cecum; Coinfection; Hydrogen; Inflammation Mediators; | 2013 |
Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
Topics: Alanine Transaminase; Animals; Catalase; Coinfection; Cytokines; Dinoprost; Disease Models, Animal; | 2012 |
Recently published papers: more about EGDT, experimental therapies and some inconvenient truths.
Topics: Animals; Critical Care; Cytochromes c; Disease Models, Animal; Education, Medical; Humans; Hydrogen; | 2007 |