Page last updated: 2024-10-18

glycine and Sepsis

glycine has been researched along with Sepsis in 30 studies

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"To determine whether administration of glycine, a nonessential amino acid, early after the onset of polymicrobial sepsis has any beneficial effects on hepatocellular function and the survivability of septic animals and, if so, whether the beneficial effects of glycine are associated with down-regulation of proinflammatory cytokine tumor necrosis factor-alpha production."9.09Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality. ( Chaudry, IH; Koo, DJ; Wang, P; Yang, S, 2001)
" The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0."7.79Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013)
"The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established."7.78Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012)
" To investigate hydrogen sulfide-mediated neurogenic inflammation in sepsis, DL-propargylglycine (50 mg/kg intraperitoneal), an inhibitor of hydrogen sulfide formation was administrated 1 hr before or 1 hr after the induction of sepsis, whereas sodium hydrosulfide (10 mg/kg intraperitoneal), a hydrogen sulfide donor, was given at the same time as cecal ligation and puncture."7.76Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. ( Ang, SF; Bhatia, M; Moochhala, SM, 2010)
"In the untreated rats with sepsis, the mean arterial pressure (MAP) and glomerular filtration rate (GFR) were decreased, whereas serum blood urea nitrogen (BUN) and neutrophil gelatinase-associated lipocalin (NGAL) levels were increased."5.43The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. ( Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X, 2016)
"Sivelestat is a selective neutrophil elastase inhibitor."5.36Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010)
"To determine whether administration of glycine, a nonessential amino acid, early after the onset of polymicrobial sepsis has any beneficial effects on hepatocellular function and the survivability of septic animals and, if so, whether the beneficial effects of glycine are associated with down-regulation of proinflammatory cytokine tumor necrosis factor-alpha production."5.09Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality. ( Chaudry, IH; Koo, DJ; Wang, P; Yang, S, 2001)
"Sixty Sprague-Dawley (SD) rats were randomly divided into sham control (SC), sepsis (CLP), and sepsis+Sivelestat (Sive) groups."4.12Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats. ( Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X, 2022)
" The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0."3.79Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013)
"An imbalance between glutamate and glycine signalling may contribute to sepsis-associated encephalopathy by causing neuronal excitotoxicity."3.78Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans. ( Bailey, DM; Berg, RM; Larsen, FS; Lundby, C; Møller, K; Pedersen, BK; Taudorf, S, 2012)
"The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established."3.78Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012)
" To investigate hydrogen sulfide-mediated neurogenic inflammation in sepsis, DL-propargylglycine (50 mg/kg intraperitoneal), an inhibitor of hydrogen sulfide formation was administrated 1 hr before or 1 hr after the induction of sepsis, whereas sodium hydrosulfide (10 mg/kg intraperitoneal), a hydrogen sulfide donor, was given at the same time as cecal ligation and puncture."3.76Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. ( Ang, SF; Bhatia, M; Moochhala, SM, 2010)
"Recent studies indicated that prefeeding of a glycine supplemented diet reduces the hepatic inflammatory response and liver damage in sepsis."3.73Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats. ( Croner, RS; Herfarth, C; Hoerer, E; Klar, E; Kulu, Y; Peters, V; Schemmer, P; Schmidt-Mader, B, 2005)
"Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection."1.72Dichloroacetate improves systemic energy balance and feeding behavior during sepsis. ( Jain, S; Long, D; McCall, CE; Oh, TS; Quinn, MA; Stacpoole, PW; Zabalawi, M, 2022)
"In the untreated rats with sepsis, the mean arterial pressure (MAP) and glomerular filtration rate (GFR) were decreased, whereas serum blood urea nitrogen (BUN) and neutrophil gelatinase-associated lipocalin (NGAL) levels were increased."1.43The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. ( Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X, 2016)
"Sepsis was induced by caecum ligation and puncture (CLP)."1.42Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model. ( Chen, J; Ding, C; Gu, G; Hu, D; Li, J; Liu, S; Ren, J; Wang, G; Wu, X; Wu, Y; Zhou, B, 2015)
"Sivelestat is a selective neutrophil elastase inhibitor."1.36Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010)
"Treatment with sivelestat significantly improved the survival rate of the post-CLP septic animals (P = 0."1.36Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. ( Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H, 2010)
"Therefore, neonatal foals with septicemia had significant differences in the concentrations of several amino acids in their plasma, compared with concentrations from healthy foals."1.28Concentrations of amino acids in the plasma of neonatal foals with septicemia. ( Rogers, QR; Spensley, MS; Willits, NH; Zicker, SC, 1991)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19906 (20.00)18.7374
1990's2 (6.67)18.2507
2000's8 (26.67)29.6817
2010's10 (33.33)24.3611
2020's4 (13.33)2.80

Authors

AuthorsStudies
Sun, Y1
Ding, X1
Cui, Y1
Li, H1
Wang, D1
Liang, H1
Liu, S2
Zhang, X2
Wang, H2
Sun, T1
Oh, TS1
Zabalawi, M1
Jain, S1
Long, D1
Stacpoole, PW1
McCall, CE1
Quinn, MA1
Han, F1
Wu, G1
Han, S1
Li, Z1
Jia, Y1
Bai, L1
Li, X1
Wang, K1
Yang, F1
Zhang, J1
Wang, X1
Guan, H1
Linlin, S1
Han, J1
Hu, D2
Wang, Y1
Du, P1
Jiang, D1
Cho, YS1
Moon, JM1
Chun, BJ1
Lee, BK1
Miyoshi, S1
Hamada, H1
Ito, R1
Katayama, H1
Irifune, K1
Suwaki, T1
Nakanishi, N1
Kanematsu, T1
Dote, K1
Aibiki, M1
Okura, T1
Higaki, J1
Yuan, Q1
Jiang, YW1
Fang, QH1
Wu, Y1
Ren, J1
Zhou, B1
Ding, C1
Chen, J1
Wang, G1
Gu, G1
Wu, X1
Li, J1
Li, G1
Jia, J1
Ji, K1
Gong, X1
Wang, R1
Zang, B1
Hayakawa, M1
Katabami, K1
Wada, T1
Sugano, M1
Hoshino, H1
Sawamura, A1
Gando, S1
Ang, SF1
Moochhala, SM2
Bhatia, M4
Suda, K1
Takeuchi, H1
Hagiwara, T1
Miyasho, T1
Okamoto, M1
Kawasako, K1
Yamada, S1
Suganuma, K1
Wada, N1
Saikawa, Y1
Fukunaga, K1
Funakoshi, Y1
Hashimoto, S1
Yokota, H1
Maruyama, I1
Ishizaka, A1
Kitagawa, Y1
Berg, RM1
Taudorf, S1
Bailey, DM1
Lundby, C1
Larsen, FS1
Pedersen, BK1
Møller, K1
Tsuboko, Y1
Takeda, S1
Mii, S1
Nakazato, K1
Tanaka, K1
Uchida, E1
Sakamoto, A1
Bellomo, R1
Uchino, S1
Naka, T1
Wan, L1
Croner, RS1
Kulu, Y1
Hoerer, E1
Peters, V1
Schmidt-Mader, B1
Schemmer, P1
Herfarth, C1
Klar, E1
Zhang, H3
Zhi, L3
Moore, PK3
Moochhala, S1
Weiss, G1
Madsen, HO1
Garred, P1
Schultz, K1
Mestyán, J1
Soltész, G1
Klujber, L1
Dóber, I1
David, SA1
Silverstein, R1
Amura, CR1
Kielian, T1
Morrison, DC1
Yang, S1
Koo, DJ1
Chaudry, IH1
Wang, P1
Grotz, MR1
Pape, HC1
van Griensven, M1
Stalp, M1
Rohde, F1
Bock, D1
Krettek, C1
Zicker, SC1
Spensley, MS1
Rogers, QR1
Willits, NH1
Ishida, K1
Totsuka, M1
Hayasaka, H1
Ishibashi, T1
Harada, Y1
Takamoto, M1
Shinoda, A1
Miloszewski, K1
Sheltawy, MJ1
Losowsky, MS1
Schrot, JR1
Hess, WC1
Levin, GV1
Desmond, J1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Perioperative Application of Sivelestat Sodium in Acute Type A Aortic Dissection Patients With Preoperative Moderate to Severe Hypoxemia to Shorten the Duration of Postoperative Invasive Mechanical Ventilation[NCT05874700]30 participants (Anticipated)Interventional2023-05-31Not yet recruiting
Clinical Study of Neutrophil Elastase Inhibitor in Treatment of Acute Respiratory Distress Syndrome Patients With Mechanical Ventilation Caused by Sepsis[NCT05672472]100 participants (Anticipated)Interventional2023-01-10Not yet recruiting
Hydrogen Sulfide as Prognostic Factor[NCT01088490]50 participants (Actual)Observational2010-01-31Completed
A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091]Phase 220 participants (Anticipated)Interventional2019-08-05Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for glycine and Sepsis

ArticleYear
Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality.
    Critical care medicine, 2001, Volume: 29, Issue:6

    Topics: Analysis of Variance; Animals; Calcium; Cecum; Coloring Agents; Down-Regulation; Enzyme-Linked Immun

2001

Other Studies

29 other studies available for glycine and Sepsis

ArticleYear
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats

2022
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis.
    JCI insight, 2022, 06-22, Volume: 7, Issue:12

    Topics: Acetates; Animals; Energy Metabolism; Feeding Behavior; Glycine; Inflammation; Mice; Sepsis

2022
Hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat (FG-4592) alleviates sepsis-induced acute lung injury.
    Respiratory physiology & neurobiology, 2020, Volume: 281

    Topics: Acute Lung Injury; Animals; Cells, Cultured; Disease Models, Animal; Glycine; Hypoxia-Inducible Fact

2020
Rigosertib inhibits MEK1-ERK pathway and alleviates lipopolysaccharide-induced sepsis.
    Immunity, inflammation and disease, 2021, Volume: 9, Issue:3

    Topics: Animals; Glycine; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Sepsis; Sulfones

2021
Use of qSOFA Score in Predicting the Outcomes of Patients With Glyphosate Surfactant Herbicide Poisoning Immediately Upon Arrival at the Emergency Department.
    Shock (Augusta, Ga.), 2019, Volume: 51, Issue:4

    Topics: Aged; Area Under Curve; Emergency Service, Hospital; Glycine; Glyphosate; Herbicides; Hospital Morta

2019
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male;

2013
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male;

2013
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male;

2013
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male;

2013
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2014, Volume: 122, Issue:9

    Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte

2014
Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model.
    Clinical and experimental immunology, 2015, Volume: 179, Issue:2

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cytokines; Gene Silencing; Glycine; Hepatocytes; Hy

2015
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
    International journal of molecular medicine, 2016, Volume: 38, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Fil

2016
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:1

    Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Res

2010
Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
    Critical care medicine, 2010, Volume: 38, Issue:2

    Topics: Alkynes; Animals; Capsaicin; Cystathionine gamma-Lyase; Glycine; Hydrogen Sulfide; Liver; Lung; Male

2010
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:5

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Gly

2010
Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2012, Volume: 120, Issue:9

    Topics: Adult; Brain; Glutamic Acid; Glycine; Humans; Kinetics; Lipopolysaccharides; Male; Sepsis; Tumor Nec

2012
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
    Drug design, development and therapy, 2012, Volume: 6

    Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complica

2012
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
    Intensive care medicine, 2004, Volume: 30, Issue:5

    Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glyc

2004
Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats.
    Microvascular research, 2005, Volume: 69, Issue:1-2

    Topics: Animals; Cecum; Cell Adhesion; Cell Survival; Glycine; Immunohistochemistry; Intercellular Adhesion

2005
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:6

    Topics: Alkynes; Animals; Cecum; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Liver

2006
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4

    Topics: Alkynes; Animals; Cecum; Chemokines; Cystathionine gamma-Lyase; Cytokines; Disease Models, Animal; G

2007
A novel mannose-binding lectin-associated serine protease 1/3 gene variant.
    Scandinavian journal of immunology, 2007, Volume: 65, Issue:5

    Topics: Amino Acid Substitution; Genetic Variation; Glutamic Acid; Glycine; Humans; Inflammation; Lupus Eryt

2007
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis.
    Journal of leukocyte biology, 2007, Volume: 82, Issue:4

    Topics: Alkynes; Animals; Cell Adhesion; Cell Adhesion Molecules; Chemokine CXCL2; Enzyme Inhibitors; Glycin

2007
Metabolic effects of septicaemia in newborn and young infants with particular reference to the plasma free amino acids.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1980, Volume: 21, Issue:4

    Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Bacterial Infections; Escherichia coli Infections

1980
Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:4

    Topics: Animals; Cytokines; Fatty Acids, Monounsaturated; Female; Glycine; Gram-Negative Bacteria; Lipopolys

1999
Glycine reduces the inflammatory response and organ damage in a two-hit sepsis model in rats.
    Shock (Augusta, Ga.), 2001, Volume: 16, Issue:2

    Topics: Amino Acids; Animals; Cytokines; Disease Models, Animal; Endotoxins; Glycine; Inflammation; Liver Fu

2001
Concentrations of amino acids in the plasma of neonatal foals with septicemia.
    American journal of veterinary research, 1991, Volume: 52, Issue:7

    Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Arginine; Citrulline; Female; Glycine; Gram-Negativ

1991
[Alanine metabolism in the skeletal muscle and plasma in endotoxemia].
    Nihon Geka Gakkai zasshi, 1985, Volume: 86, Issue:4

    Topics: Alanine; Animals; Glycine; Muscles; Proline; Rabbits; Sepsis; Shock, Septic

1985
Immunopotentiation with forphenicinol: increased resistance to Pseudomonas septicaemia in mice.
    The Journal of antibiotics, 1985, Volume: 38, Issue:3

    Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Blood Bactericidal Activity; Female; Glycine

1985
Fibrinogen-fibrin degradation products and factor XIII.
    Acta haematologica, 1974, Volume: 51, Issue:6

    Topics: Blood Coagulation Tests; Carbon Radioisotopes; Carcinoma; Caseins; Disseminated Intravascular Coagul

1974
Method for radiorespirometric detection of bacteria in pure culture and in blood.
    Applied microbiology, 1973, Volume: 26, Issue:6

    Topics: Bacteria; Bacteriological Techniques; Carbon Dioxide; Carbon Radioisotopes; Diagnosis, Differential;

1973
Complications of transurethral prostatic surgery.
    Canadian Anaesthetists' Society journal, 1970, Volume: 17, Issue:1

    Topics: Age Factors; Aged; Burns, Electric; Cardiovascular Diseases; Glycine; Hemorrhage; Humans; Male; Midd

1970