Page last updated: 2024-10-18
glycine and Sepsis
glycine has been researched along with Sepsis in 30 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether administration of glycine, a nonessential amino acid, early after the onset of polymicrobial sepsis has any beneficial effects on hepatocellular function and the survivability of septic animals and, if so, whether the beneficial effects of glycine are associated with down-regulation of proinflammatory cytokine tumor necrosis factor-alpha production." | 9.09 | Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality. ( Chaudry, IH; Koo, DJ; Wang, P; Yang, S, 2001) |
| " The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0." | 7.79 | Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013) |
| "The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established." | 7.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| " To investigate hydrogen sulfide-mediated neurogenic inflammation in sepsis, DL-propargylglycine (50 mg/kg intraperitoneal), an inhibitor of hydrogen sulfide formation was administrated 1 hr before or 1 hr after the induction of sepsis, whereas sodium hydrosulfide (10 mg/kg intraperitoneal), a hydrogen sulfide donor, was given at the same time as cecal ligation and puncture." | 7.76 | Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. ( Ang, SF; Bhatia, M; Moochhala, SM, 2010) |
| "In the untreated rats with sepsis, the mean arterial pressure (MAP) and glomerular filtration rate (GFR) were decreased, whereas serum blood urea nitrogen (BUN) and neutrophil gelatinase-associated lipocalin (NGAL) levels were increased." | 5.43 | The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. ( Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X, 2016) |
| "Sivelestat is a selective neutrophil elastase inhibitor." | 5.36 | Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010) |
| "To determine whether administration of glycine, a nonessential amino acid, early after the onset of polymicrobial sepsis has any beneficial effects on hepatocellular function and the survivability of septic animals and, if so, whether the beneficial effects of glycine are associated with down-regulation of proinflammatory cytokine tumor necrosis factor-alpha production." | 5.09 | Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality. ( Chaudry, IH; Koo, DJ; Wang, P; Yang, S, 2001) |
| "Sixty Sprague-Dawley (SD) rats were randomly divided into sham control (SC), sepsis (CLP), and sepsis+Sivelestat (Sive) groups." | 4.12 | Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats. ( Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X, 2022) |
| " The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0." | 3.79 | Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis. ( Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T, 2013) |
| "An imbalance between glutamate and glycine signalling may contribute to sepsis-associated encephalopathy by causing neuronal excitotoxicity." | 3.78 | Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans. ( Bailey, DM; Berg, RM; Larsen, FS; Lundby, C; Møller, K; Pedersen, BK; Taudorf, S, 2012) |
| "The efficacy of sivelestat in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has not been established." | 3.78 | Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. ( Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E, 2012) |
| " To investigate hydrogen sulfide-mediated neurogenic inflammation in sepsis, DL-propargylglycine (50 mg/kg intraperitoneal), an inhibitor of hydrogen sulfide formation was administrated 1 hr before or 1 hr after the induction of sepsis, whereas sodium hydrosulfide (10 mg/kg intraperitoneal), a hydrogen sulfide donor, was given at the same time as cecal ligation and puncture." | 3.76 | Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. ( Ang, SF; Bhatia, M; Moochhala, SM, 2010) |
| "Recent studies indicated that prefeeding of a glycine supplemented diet reduces the hepatic inflammatory response and liver damage in sepsis." | 3.73 | Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats. ( Croner, RS; Herfarth, C; Hoerer, E; Klar, E; Kulu, Y; Peters, V; Schemmer, P; Schmidt-Mader, B, 2005) |
| "Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection." | 1.72 | Dichloroacetate improves systemic energy balance and feeding behavior during sepsis. ( Jain, S; Long, D; McCall, CE; Oh, TS; Quinn, MA; Stacpoole, PW; Zabalawi, M, 2022) |
| "In the untreated rats with sepsis, the mean arterial pressure (MAP) and glomerular filtration rate (GFR) were decreased, whereas serum blood urea nitrogen (BUN) and neutrophil gelatinase-associated lipocalin (NGAL) levels were increased." | 1.43 | The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. ( Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X, 2016) |
| "Sepsis was induced by caecum ligation and puncture (CLP)." | 1.42 | Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model. ( Chen, J; Ding, C; Gu, G; Hu, D; Li, J; Liu, S; Ren, J; Wang, G; Wu, X; Wu, Y; Zhou, B, 2015) |
| "Sivelestat is a selective neutrophil elastase inhibitor." | 1.36 | Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. ( Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T, 2010) |
| "Treatment with sivelestat significantly improved the survival rate of the post-CLP septic animals (P = 0." | 1.36 | Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. ( Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H, 2010) |
| "Therefore, neonatal foals with septicemia had significant differences in the concentrations of several amino acids in their plasma, compared with concentrations from healthy foals." | 1.28 | Concentrations of amino acids in the plasma of neonatal foals with septicemia. ( Rogers, QR; Spensley, MS; Willits, NH; Zicker, SC, 1991) |
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Ding, X | 1 |
| Cui, Y | 1 |
| Li, H | 1 |
| Wang, D | 1 |
| Liang, H | 1 |
| Liu, S | 2 |
| Zhang, X | 2 |
| Wang, H | 2 |
| Sun, T | 1 |
| Oh, TS | 1 |
| Zabalawi, M | 1 |
| Jain, S | 1 |
| Long, D | 1 |
| Stacpoole, PW | 1 |
| McCall, CE | 1 |
| Quinn, MA | 1 |
| Han, F | 1 |
| Wu, G | 1 |
| Han, S | 1 |
| Li, Z | 1 |
| Jia, Y | 1 |
| Bai, L | 1 |
| Li, X | 1 |
| Wang, K | 1 |
| Yang, F | 1 |
| Zhang, J | 1 |
| Wang, X | 1 |
| Guan, H | 1 |
| Linlin, S | 1 |
| Han, J | 1 |
| Hu, D | 2 |
| Wang, Y | 1 |
| Du, P | 1 |
| Jiang, D | 1 |
| Cho, YS | 1 |
| Moon, JM | 1 |
| Chun, BJ | 1 |
| Lee, BK | 1 |
| Miyoshi, S | 1 |
| Hamada, H | 1 |
| Ito, R | 1 |
| Katayama, H | 1 |
| Irifune, K | 1 |
| Suwaki, T | 1 |
| Nakanishi, N | 1 |
| Kanematsu, T | 1 |
| Dote, K | 1 |
| Aibiki, M | 1 |
| Okura, T | 1 |
| Higaki, J | 1 |
| Yuan, Q | 1 |
| Jiang, YW | 1 |
| Fang, QH | 1 |
| Wu, Y | 1 |
| Ren, J | 1 |
| Zhou, B | 1 |
| Ding, C | 1 |
| Chen, J | 1 |
| Wang, G | 1 |
| Gu, G | 1 |
| Wu, X | 1 |
| Li, J | 1 |
| Li, G | 1 |
| Jia, J | 1 |
| Ji, K | 1 |
| Gong, X | 1 |
| Wang, R | 1 |
| Zang, B | 1 |
| Hayakawa, M | 1 |
| Katabami, K | 1 |
| Wada, T | 1 |
| Sugano, M | 1 |
| Hoshino, H | 1 |
| Sawamura, A | 1 |
| Gando, S | 1 |
| Ang, SF | 1 |
| Moochhala, SM | 2 |
| Bhatia, M | 4 |
| Suda, K | 1 |
| Takeuchi, H | 1 |
| Hagiwara, T | 1 |
| Miyasho, T | 1 |
| Okamoto, M | 1 |
| Kawasako, K | 1 |
| Yamada, S | 1 |
| Suganuma, K | 1 |
| Wada, N | 1 |
| Saikawa, Y | 1 |
| Fukunaga, K | 1 |
| Funakoshi, Y | 1 |
| Hashimoto, S | 1 |
| Yokota, H | 1 |
| Maruyama, I | 1 |
| Ishizaka, A | 1 |
| Kitagawa, Y | 1 |
| Berg, RM | 1 |
| Taudorf, S | 1 |
| Bailey, DM | 1 |
| Lundby, C | 1 |
| Larsen, FS | 1 |
| Pedersen, BK | 1 |
| Møller, K | 1 |
| Tsuboko, Y | 1 |
| Takeda, S | 1 |
| Mii, S | 1 |
| Nakazato, K | 1 |
| Tanaka, K | 1 |
| Uchida, E | 1 |
| Sakamoto, A | 1 |
| Bellomo, R | 1 |
| Uchino, S | 1 |
| Naka, T | 1 |
| Wan, L | 1 |
| Croner, RS | 1 |
| Kulu, Y | 1 |
| Hoerer, E | 1 |
| Peters, V | 1 |
| Schmidt-Mader, B | 1 |
| Schemmer, P | 1 |
| Herfarth, C | 1 |
| Klar, E | 1 |
| Zhang, H | 3 |
| Zhi, L | 3 |
| Moore, PK | 3 |
| Moochhala, S | 1 |
| Weiss, G | 1 |
| Madsen, HO | 1 |
| Garred, P | 1 |
| Schultz, K | 1 |
| Mestyán, J | 1 |
| Soltész, G | 1 |
| Klujber, L | 1 |
| Dóber, I | 1 |
| David, SA | 1 |
| Silverstein, R | 1 |
| Amura, CR | 1 |
| Kielian, T | 1 |
| Morrison, DC | 1 |
| Yang, S | 1 |
| Koo, DJ | 1 |
| Chaudry, IH | 1 |
| Wang, P | 1 |
| Grotz, MR | 1 |
| Pape, HC | 1 |
| van Griensven, M | 1 |
| Stalp, M | 1 |
| Rohde, F | 1 |
| Bock, D | 1 |
| Krettek, C | 1 |
| Zicker, SC | 1 |
| Spensley, MS | 1 |
| Rogers, QR | 1 |
| Willits, NH | 1 |
| Ishida, K | 1 |
| Totsuka, M | 1 |
| Hayasaka, H | 1 |
| Ishibashi, T | 1 |
| Harada, Y | 1 |
| Takamoto, M | 1 |
| Shinoda, A | 1 |
| Miloszewski, K | 1 |
| Sheltawy, MJ | 1 |
| Losowsky, MS | 1 |
| Schrot, JR | 1 |
| Hess, WC | 1 |
| Levin, GV | 1 |
| Desmond, J | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Perioperative Application of Sivelestat Sodium in Acute Type A Aortic Dissection Patients With Preoperative Moderate to Severe Hypoxemia to Shorten the Duration of Postoperative Invasive Mechanical Ventilation[NCT05874700] | 30 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| Clinical Study of Neutrophil Elastase Inhibitor in Treatment of Acute Respiratory Distress Syndrome Patients With Mechanical Ventilation Caused by Sepsis[NCT05672472] | 100 participants (Anticipated) | Interventional | 2023-01-10 | Not yet recruiting | |||
| Hydrogen Sulfide as Prognostic Factor[NCT01088490] | 50 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| A Phase II Double Blind Randomized Controlled Trial of High Dose Vitamin B12 in Septic Shock[NCT03783091] | Phase 2 | 20 participants (Anticipated) | Interventional | 2019-08-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
1 trial available for glycine and Sepsis
| Article | Year |
|---|---|
Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality.
Topics: Analysis of Variance; Animals; Calcium; Cecum; Coloring Agents; Down-Regulation; Enzyme-Linked Immun | 2001 |
Other Studies
29 other studies available for glycine and Sepsis
| Article | Year |
|---|---|
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats | 2022 |
Dichloroacetate improves systemic energy balance and feeding behavior during sepsis.
Topics: Acetates; Animals; Energy Metabolism; Feeding Behavior; Glycine; Inflammation; Mice; Sepsis | 2022 |
Hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat (FG-4592) alleviates sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cells, Cultured; Disease Models, Animal; Glycine; Hypoxia-Inducible Fact | 2020 |
Rigosertib inhibits MEK1-ERK pathway and alleviates lipopolysaccharide-induced sepsis.
Topics: Animals; Glycine; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Sepsis; Sulfones | 2021 |
Use of qSOFA Score in Predicting the Outcomes of Patients With Glyphosate Surfactant Herbicide Poisoning Immediately Upon Arrival at the Emergency Department.
Topics: Aged; Area Under Curve; Emergency Service, Hospital; Glycine; Glyphosate; Herbicides; Hospital Morta | 2019 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; | 2013 |
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte | 2014 |
Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model.
Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cytokines; Gene Silencing; Glycine; Hepatocytes; Hy | 2015 |
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Fil | 2016 |
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Res | 2010 |
Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
Topics: Alkynes; Animals; Capsaicin; Cystathionine gamma-Lyase; Glycine; Hydrogen Sulfide; Liver; Lung; Male | 2010 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Gly | 2010 |
Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans.
Topics: Adult; Brain; Glutamic Acid; Glycine; Humans; Kinetics; Lipopolysaccharides; Male; Sepsis; Tumor Nec | 2012 |
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complica | 2012 |
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glyc | 2004 |
Intravenous glycine after cecal ligation and puncture has no effect on impaired hepatic microperfusion, leukocyte adhesion, and mortality in septic rats.
Topics: Animals; Cecum; Cell Adhesion; Cell Survival; Glycine; Immunohistochemistry; Intercellular Adhesion | 2005 |
Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
Topics: Alkynes; Animals; Cecum; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hydrogen Sulfide; Liver | 2006 |
Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB.
Topics: Alkynes; Animals; Cecum; Chemokines; Cystathionine gamma-Lyase; Cytokines; Disease Models, Animal; G | 2007 |
A novel mannose-binding lectin-associated serine protease 1/3 gene variant.
Topics: Amino Acid Substitution; Genetic Variation; Glutamic Acid; Glycine; Humans; Inflammation; Lupus Eryt | 2007 |
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis.
Topics: Alkynes; Animals; Cell Adhesion; Cell Adhesion Molecules; Chemokine CXCL2; Enzyme Inhibitors; Glycin | 2007 |
Metabolic effects of septicaemia in newborn and young infants with particular reference to the plasma free amino acids.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Bacterial Infections; Escherichia coli Infections | 1980 |
Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria.
Topics: Animals; Cytokines; Fatty Acids, Monounsaturated; Female; Glycine; Gram-Negative Bacteria; Lipopolys | 1999 |
Glycine reduces the inflammatory response and organ damage in a two-hit sepsis model in rats.
Topics: Amino Acids; Animals; Cytokines; Disease Models, Animal; Endotoxins; Glycine; Inflammation; Liver Fu | 2001 |
Concentrations of amino acids in the plasma of neonatal foals with septicemia.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Arginine; Citrulline; Female; Glycine; Gram-Negativ | 1991 |
[Alanine metabolism in the skeletal muscle and plasma in endotoxemia].
Topics: Alanine; Animals; Glycine; Muscles; Proline; Rabbits; Sepsis; Shock, Septic | 1985 |
Immunopotentiation with forphenicinol: increased resistance to Pseudomonas septicaemia in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Blood Bactericidal Activity; Female; Glycine | 1985 |
Fibrinogen-fibrin degradation products and factor XIII.
Topics: Blood Coagulation Tests; Carbon Radioisotopes; Carcinoma; Caseins; Disseminated Intravascular Coagul | 1974 |
Method for radiorespirometric detection of bacteria in pure culture and in blood.
Topics: Bacteria; Bacteriological Techniques; Carbon Dioxide; Carbon Radioisotopes; Diagnosis, Differential; | 1973 |
Complications of transurethral prostatic surgery.
Topics: Age Factors; Aged; Burns, Electric; Cardiovascular Diseases; Glycine; Hemorrhage; Humans; Male; Midd | 1970 |