glycine and Dystonia
glycine has been researched along with Dystonia in 7 studies
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)." | 9.14 | Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009) |
| "The effects of R-(+)-HA-966 ((+)-3-amino-1-hydroxypyrrolid-2-one), a low-efficacy partial agonist of the glycine modulatory site of the NMDA receptor complex, were studied in an inbred line of Syrian golden hamsters with generalized dystonia, a frequent movement disorder in humans." | 7.68 | The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia. ( Löscher, W; Richter, A, 1993) |
| "Since glycinergic neurotransmission plays an important inhibitory role in the processing of sensory and motor information, intrathecal glycine (ITG) administration may be a potential therapy for both pain and movement disorders in patients with complex regional pain syndrome (CRPS)." | 5.14 | Intrathecal glycine for pain and dystonia in complex regional pain syndrome. ( Marinus, J; Munts, AG; Onkenhout, W; Teepe-Twiss, IM; van der Plas, AA; van Gerven, JM; van Hilten, JJ; Voormolen, JH, 2009) |
| "The effects of R-(+)-HA-966 ((+)-3-amino-1-hydroxypyrrolid-2-one), a low-efficacy partial agonist of the glycine modulatory site of the NMDA receptor complex, were studied in an inbred line of Syrian golden hamsters with generalized dystonia, a frequent movement disorder in humans." | 3.68 | The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia. ( Löscher, W; Richter, A, 1993) |
| "To study parkinsonism, dementia, dystonia, and amyotrophy as subphenotypes of SCA2, and to explore the effect of CAG repeats at different loci and of mitochondrial polymorphism A10398G as modifiers of phenotype." | 1.46 | Neurological phenotypes in spinocerebellar ataxia type 2: Role of mitochondrial polymorphism A10398G and other risk factors. ( Augustin, MC; Barsottini, O; Jardim, LB; Locks-Coelho, LD; Monte, TL; Pedroso, JL; Pereira, FS; Reckziegel, EDR; Santos, ASP; Saraiva-Pereira, ML; Vargas, FR, 2017) |
| "Since dystonia in mutant dtSZ hamsters is transient and disappears after about 70 days of age, amino acids were determined at the age of maximum severity of dystonia (30-40 days) and after disappearance of the disease, to examine which neurochemical changes were related to dystonia." | 1.28 | Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters. ( Hörstermann, D; Löscher, W, 1992) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Monte, TL | 1 |
| Pereira, FS | 1 |
| Reckziegel, EDR | 1 |
| Augustin, MC | 1 |
| Locks-Coelho, LD | 1 |
| Santos, ASP | 1 |
| Pedroso, JL | 1 |
| Barsottini, O | 1 |
| Vargas, FR | 1 |
| Saraiva-Pereira, ML | 1 |
| Jardim, LB | 1 |
| Li, M | 1 |
| Niu, F | 1 |
| Zhu, X | 1 |
| Wu, X | 1 |
| Shen, N | 1 |
| Peng, X | 1 |
| Liu, Y | 1 |
| Munts, AG | 1 |
| van der Plas, AA | 1 |
| Voormolen, JH | 1 |
| Marinus, J | 1 |
| Teepe-Twiss, IM | 1 |
| Onkenhout, W | 1 |
| van Gerven, JM | 1 |
| van Hilten, JJ | 1 |
| Hwu, WL | 1 |
| Lu, MY | 1 |
| Hwa, KY | 1 |
| Fan, SW | 1 |
| Lee, YM | 1 |
| Löscher, W | 2 |
| Richter, A | 1 |
| Miwa, H | 1 |
| Nishi, K | 1 |
| Fuwa, T | 1 |
| Mizuno, Y | 1 |
| Hörstermann, D | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
1 trial available for glycine and Dystonia
| Article | Year |
|---|---|
Intrathecal glycine for pain and dystonia in complex regional pain syndrome.
Topics: Adult; Complex Regional Pain Syndromes; Cross-Over Studies; Double-Blind Method; Dystonia; Female; G | 2009 |
Other Studies
6 other studies available for glycine and Dystonia
| Article | Year |
|---|---|
Neurological phenotypes in spinocerebellar ataxia type 2: Role of mitochondrial polymorphism A10398G and other risk factors.
Topics: Adult; Aged; Alanine; Ataxin-2; Dementia; Dystonia; Female; Genetic Predisposition to Disease; Glyci | 2017 |
PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling.
Topics: Adolescent; Adult; Age of Onset; Animals; Aspartic Acid; Case-Control Studies; Cell Line; Cell Membr | 2015 |
Molecular chaperones affect GTP cyclohydrolase I mutations in dopa-responsive dystonia.
Topics: Animals; Animals, Newborn; Benzoquinones; Blotting, Northern; Blotting, Western; Cell Line; Cricetin | 2004 |
The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia.
Topics: Animals; Behavior, Animal; Cricetinae; Cycloserine; Disease Models, Animal; Dystonia; Female; Glycin | 1993 |
Effects of blockade of metabotropic glutamate receptors in the subthalamic nucleus on haloperidol-induced Parkinsonism in rats.
Topics: Animals; Benzoates; Dopamine Antagonists; Dystonia; Excitatory Amino Acid Antagonists; Glycine; Halo | 2000 |
Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters.
Topics: Animals; Aspartic Acid; Cerebellum; Chromatography, High Pressure Liquid; Corpus Striatum; Cricetina | 1992 |