Page last updated: 2024-10-28

glyburide and Sepsis

glyburide has been researched along with Sepsis in 7 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
" We further show, for the first time in any model of sepsis, that glyburide acts as an anti-inflammatory agent by reducing IL1β secretion accompanied by diminished cellular influx and reduced bacterial dissemination to distant organs."3.79Glyburide reduces bacterial dissemination in a mouse model of melioidosis. ( Bast, A; Breitbach, K; de Jong, HK; Hoogendijk, AJ; Kager, LM; Koh, GC; Krause, K; Peacock, SJ; Steinmetz, I; van der Poll, T; Weehuizen, TA; Wiersinga, WJ, 2013)
"Sepsis is a common disease that continues to increase in incidence in the world."1.40Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice. ( Cai, J; Deng, YP; Jiang, GJ; Lu, S; Ren, GF; Shen, FM; Yao, Z; Yu, JW; Zhang, LD, 2014)
"Glyburide is an oral hypoglycemic agent used to treat diabetes mellitus."1.37Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis. ( Chaowagul, W; Chierakul, W; Day, NP; Dougan, G; Koh, GC; Lee, SJ; Limmathurotsakul, D; Mahavanakul, W; Maude, RR; Peacock, SJ; Schreiber, MF; van der Poll, T; White, NJ; Wiersinga, WJ; Wuthiekanun, V, 2011)
"Sepsis was induced by caecal ligation and puncture (CLP) or sham surgery in Wistar rats."1.37Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction. ( Assreuy, J; Fernandes, D; Heckert, BT; Sordi, R, 2011)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Koh, GC2
Weehuizen, TA1
Breitbach, K1
Krause, K1
de Jong, HK1
Kager, LM1
Hoogendijk, AJ1
Bast, A1
Peacock, SJ2
van der Poll, T2
Steinmetz, I1
Wiersinga, WJ2
Cai, J1
Lu, S1
Yao, Z1
Deng, YP1
Zhang, LD1
Yu, JW1
Ren, GF1
Shen, FM1
Jiang, GJ1
Beck, C1
Barthel, F1
Hahn, AM1
Vollmer, C1
Herminghaus, A1
Schäfer, S1
Bauer, I1
Picker, O1
Sordi, R2
Fernandes, D2
Assreuy, J2
Maude, RR1
Schreiber, MF1
Limmathurotsakul, D1
Wuthiekanun, V1
Lee, SJ1
Mahavanakul, W1
Chaowagul, W1
Chierakul, W1
White, NJ1
Day, NP1
Dougan, G1
Heckert, BT1
Ismail, JA1
McDonough, KH1

Other Studies

7 other studies available for glyburide and Sepsis

ArticleYear
Glyburide reduces bacterial dissemination in a mouse model of melioidosis.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Burkholderia pseudomallei; Ceftazidime; Di

2013
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice.
    Cardiovascular diabetology, 2014, Jul-31, Volume: 13

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Endotoxemia; Glyburide; Heart Injuries; H

2014
The beneficial effects of acute hypercapnia on microcirculatory oxygenation in an animal model of sepsis are independent of K(+)ATP channels.
    Microvascular research, 2015, Volume: 99

    Topics: Adenosine Triphosphate; Animals; Colon; Cytokines; Disease Models, Animal; Glyburide; Hemodynamics;

2015
Differential involvement of potassium channel subtypes in early and late sepsis-induced hyporesponsiveness to vasoconstrictors.
    Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:2

    Topics: 4-Aminopyridine; Animals; Apamin; Blood Pressure; Female; Glyburide; Muscle Contraction; Muscle, Smo

2010
Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011, Mar-15, Volume: 52, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Burkholderia pseudomallei; Cohort Studies; Female; Glyburide; Human

2011
Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction.
    British journal of pharmacology, 2011, Volume: 163, Issue:6

    Topics: Animals; Blood Pressure; Cardiovascular Diseases; Female; Gene Expression Regulation, Enzymologic; G

2011
The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts.
    Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:3

    Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circulation; Cromakalim; Escher

2001