glyburide and Sepsis
glyburide has been researched along with Sepsis in 7 studies
Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We further show, for the first time in any model of sepsis, that glyburide acts as an anti-inflammatory agent by reducing IL1β secretion accompanied by diminished cellular influx and reduced bacterial dissemination to distant organs." | 3.79 | Glyburide reduces bacterial dissemination in a mouse model of melioidosis. ( Bast, A; Breitbach, K; de Jong, HK; Hoogendijk, AJ; Kager, LM; Koh, GC; Krause, K; Peacock, SJ; Steinmetz, I; van der Poll, T; Weehuizen, TA; Wiersinga, WJ, 2013) |
| "Sepsis is a common disease that continues to increase in incidence in the world." | 1.40 | Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice. ( Cai, J; Deng, YP; Jiang, GJ; Lu, S; Ren, GF; Shen, FM; Yao, Z; Yu, JW; Zhang, LD, 2014) |
| "Glyburide is an oral hypoglycemic agent used to treat diabetes mellitus." | 1.37 | Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis. ( Chaowagul, W; Chierakul, W; Day, NP; Dougan, G; Koh, GC; Lee, SJ; Limmathurotsakul, D; Mahavanakul, W; Maude, RR; Peacock, SJ; Schreiber, MF; van der Poll, T; White, NJ; Wiersinga, WJ; Wuthiekanun, V, 2011) |
| "Sepsis was induced by caecal ligation and puncture (CLP) or sham surgery in Wistar rats." | 1.37 | Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction. ( Assreuy, J; Fernandes, D; Heckert, BT; Sordi, R, 2011) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Koh, GC | 2 |
| Weehuizen, TA | 1 |
| Breitbach, K | 1 |
| Krause, K | 1 |
| de Jong, HK | 1 |
| Kager, LM | 1 |
| Hoogendijk, AJ | 1 |
| Bast, A | 1 |
| Peacock, SJ | 2 |
| van der Poll, T | 2 |
| Steinmetz, I | 1 |
| Wiersinga, WJ | 2 |
| Cai, J | 1 |
| Lu, S | 1 |
| Yao, Z | 1 |
| Deng, YP | 1 |
| Zhang, LD | 1 |
| Yu, JW | 1 |
| Ren, GF | 1 |
| Shen, FM | 1 |
| Jiang, GJ | 1 |
| Beck, C | 1 |
| Barthel, F | 1 |
| Hahn, AM | 1 |
| Vollmer, C | 1 |
| Herminghaus, A | 1 |
| Schäfer, S | 1 |
| Bauer, I | 1 |
| Picker, O | 1 |
| Sordi, R | 2 |
| Fernandes, D | 2 |
| Assreuy, J | 2 |
| Maude, RR | 1 |
| Schreiber, MF | 1 |
| Limmathurotsakul, D | 1 |
| Wuthiekanun, V | 1 |
| Lee, SJ | 1 |
| Mahavanakul, W | 1 |
| Chaowagul, W | 1 |
| Chierakul, W | 1 |
| White, NJ | 1 |
| Day, NP | 1 |
| Dougan, G | 1 |
| Heckert, BT | 1 |
| Ismail, JA | 1 |
| McDonough, KH | 1 |
Other Studies
7 other studies available for glyburide and Sepsis
| Article | Year |
|---|---|
Glyburide reduces bacterial dissemination in a mouse model of melioidosis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Burkholderia pseudomallei; Ceftazidime; Di | 2013 |
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Endotoxemia; Glyburide; Heart Injuries; H | 2014 |
The beneficial effects of acute hypercapnia on microcirculatory oxygenation in an animal model of sepsis are independent of K(+)ATP channels.
Topics: Adenosine Triphosphate; Animals; Colon; Cytokines; Disease Models, Animal; Glyburide; Hemodynamics; | 2015 |
Differential involvement of potassium channel subtypes in early and late sepsis-induced hyporesponsiveness to vasoconstrictors.
Topics: 4-Aminopyridine; Animals; Apamin; Blood Pressure; Female; Glyburide; Muscle Contraction; Muscle, Smo | 2010 |
Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis.
Topics: Adult; Anti-Inflammatory Agents; Burkholderia pseudomallei; Cohort Studies; Female; Glyburide; Human | 2011 |
Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Female; Gene Expression Regulation, Enzymologic; G | 2011 |
The role of K+ATP channels in the control of pre- and post-ischemic left ventricular developed pressure in septic rat hearts.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Pressure; Coronary Circulation; Cromakalim; Escher | 2001 |