Page last updated: 2024-10-27

gabapentin and Cough

gabapentin has been researched along with Cough in 31 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity."9.51The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial. ( Gao, R; Pu, J; Shi, C; Tang, J; Wang, S; Wang, X; Wen, S; Xu, X; Yu, L; Zhu, Y, 2022)
"The goal of this study was to evaluate the effectiveness of gabapentin (GBT) alone and in combination with montelukast (MTL) for improving cough."9.51The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19- related cough: A randomized, controlled clinical trial. ( Dolatshahi, K; Hakamifard, A; Khorvash, F; Nasirharandi, S; Nasirian, M; Soltani, R, 2022)
"To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough."9.30Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019)
" Adults with refractory chronic cough (>8 weeks' duration) without active respiratory disease or infection were randomly assigned to receive gabapentin (maximum tolerable daily dose of 1800 mg) or matching placebo for 10 weeks."9.16Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. ( Birring, SS; Gibson, PG; Ryan, NM, 2012)
"Recent developments in the treatment of cough include the use of speech pathology and pharmacotherapy with gabapentin."8.91Gabapentin in chronic cough. ( Gibson, PG; Vertigan, AE, 2015)
" Both high and low doses of gabapentin administration could reduce cough hypersensitivity exposed to HCl perfusion, attenuate airway inflammatory damage, and inhibit neurogenic inflammation by reducing SP expression from the airway and vagal ganglia."8.31Gabapentin alleviated the cough hypersensitivity and neurogenic inflammation in a guinea pig model with repeated intra-esophageal acid perfusion. ( Chen, R; Chen, Z; Dong, J; Huang, J; Ji, X; Xu, Y; Yan, W; Zhan, C; Zheng, Z; Zhi, H; Zhong, M, 2023)
"Response to gabapentin was defined by physician-documented subjective patient report of improvement in cough symptoms."7.85Unilateral Laryngoscopic Findings Associated With Response to Gabapentin in Patients With Chronic Cough. ( Dibildox, D; Giliberto, JP; Merati, A, 2017)
"Gabapentin has been shown to cause minimal to no toxicity in overdose."6.52A review on the efficacy and safety of gabapentin in the treatment of chronic cough. ( Ryan, NM, 2015)
"Gabapentin, a neurotransmitter modulator, is thought to treat refractory cough associated with interstitial lung disease by improving cough hypersensitivity."5.51The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial. ( Gao, R; Pu, J; Shi, C; Tang, J; Wang, S; Wang, X; Wen, S; Xu, X; Yu, L; Zhu, Y, 2022)
"The goal of this study was to evaluate the effectiveness of gabapentin (GBT) alone and in combination with montelukast (MTL) for improving cough."5.51The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19- related cough: A randomized, controlled clinical trial. ( Dolatshahi, K; Hakamifard, A; Khorvash, F; Nasirharandi, S; Nasirian, M; Soltani, R, 2022)
"To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough."5.30Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019)
" Adults with refractory chronic cough (>8 weeks' duration) without active respiratory disease or infection were randomly assigned to receive gabapentin (maximum tolerable daily dose of 1800 mg) or matching placebo for 10 weeks."5.16Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. ( Birring, SS; Gibson, PG; Ryan, NM, 2012)
", opioids and gabapentin) are centrally-acting drugs primarily used for pain and neuropathic conditions; they were not designed for cough and have limitations with respect to efficacy and safety."5.05Pharmacotherapeutic Options for Chronic Refractory Cough. ( Chung, KF; Song, WJ, 2020)
"Recent developments in the treatment of cough include the use of speech pathology and pharmacotherapy with gabapentin."4.91Gabapentin in chronic cough. ( Gibson, PG; Vertigan, AE, 2015)
"The goal of this systematic review was to examine the evidence for the use of the neuromodulating agents, amitriptyline, gabapentin, pregabalin, and baclofen, in the management of chronic, idiopathic cough patients."4.89Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. ( Cohen, SM; Misono, S, 2013)
" Both high and low doses of gabapentin administration could reduce cough hypersensitivity exposed to HCl perfusion, attenuate airway inflammatory damage, and inhibit neurogenic inflammation by reducing SP expression from the airway and vagal ganglia."4.31Gabapentin alleviated the cough hypersensitivity and neurogenic inflammation in a guinea pig model with repeated intra-esophageal acid perfusion. ( Chen, R; Chen, Z; Dong, J; Huang, J; Ji, X; Xu, Y; Yan, W; Zhan, C; Zheng, Z; Zhi, H; Zhong, M, 2023)
"Objective To evaluate the short- and long-term effects of tricyclic antidepressants (TCAs) and gabapentin in the treatment of unexplained chronic cough (UCC)."3.88Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. ( Adessa, M; Benninger, MS; Bowen, AJ; Bryson, PC; Contrera, K; Kaltenbach, J; Milstein, CF; Nowacki, AS; Taliercio, R; Trask, D, 2018)
"Response to gabapentin was defined by physician-documented subjective patient report of improvement in cough symptoms."3.85Unilateral Laryngoscopic Findings Associated With Response to Gabapentin in Patients With Chronic Cough. ( Dibildox, D; Giliberto, JP; Merati, A, 2017)
"Cough is a common respiratory symptom that is considered to be chronic when it lasts more than eight weeks."2.66Management of chronic refractory cough in adults. ( Beghè, B; Fabbri, LM; Papi, A; Spanevello, A; Visca, D, 2020)
"Gabapentin has been shown to cause minimal to no toxicity in overdose."2.52A review on the efficacy and safety of gabapentin in the treatment of chronic cough. ( Ryan, NM, 2015)
"Chronic refractory cough has factors in common with laryngeal hypersensitivity syndromes and chronic pain syndromes, and these similarities help to shed light on the pathophysiology of the condition."2.52Management of chronic refractory cough. ( Gibson, PG; Vertigan, AE, 2015)
"Chronic cough is often attributed to reflux, postnasal drip, or asthma."1.33Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. ( Lee, B; Woo, P, 2005)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (16.13)29.6817
2010's16 (51.61)24.3611
2020's10 (32.26)2.80

Authors

AuthorsStudies
Gao, R1
Xu, X3
Wang, S1
Pu, J1
Shi, C2
Wen, S1
Zhu, Y1
Tang, J1
Wang, X1
Yu, L3
Soltani, R2
Nasirharandi, S1
Khorvash, F1
Nasirian, M1
Dolatshahi, K1
Hakamifard, A2
Ito, S3
Shimamura, Y3
Matsumoto, H3
Guilleminault, L1
Demoulin-Alexikova, S1
de Gabory, L1
Bruley des Varannes, S1
Brouquières, D1
Balaguer, M1
Chapron, A1
Grassin Delyle, S1
Poussel, M1
Guibert, N1
Reychler, G1
Trzepizur, W1
Woisard, V1
Crestani, S1
Zhi, H1
Zhong, M1
Huang, J1
Zheng, Z1
Ji, X1
Xu, Y1
Dong, J1
Yan, W1
Chen, Z1
Zhan, C1
Chen, R1
Lee, MY1
Taliercio, RM1
Adessa, M2
Milstein, C1
Bryson, PC2
Song, WJ1
Chung, KF2
Zheng, C1
Childers, J1
Rabinovich, E1
Nazareth-Pidgeon, K1
Visca, D1
Beghè, B1
Fabbri, LM1
Papi, A1
Spanevello, A1
Giliberto, JP2
Dibildox, D1
Merati, A1
Bowen, AJ1
Nowacki, AS1
Contrera, K1
Trask, D1
Kaltenbach, J1
Milstein, CF1
Benninger, MS1
Taliercio, R1
Dong, R2
Ding, H1
Pan, J1
Yu, Y1
Chen, Q1
Zhang, M1
Lv, H1
Qiu, Z2
Naik, RD1
Vaezi, MF1
Wu, CH1
Gunasekara, K1
Hull, JH1
Bikov, A1
Morris, AJ1
Usmani, OS1
Ryan, NM2
Gibson, PG3
Vertigan, AE2
Bonnet, U1
Ossowski, A1
Schubert, M1
Gall, H1
Steinkamp, I1
Richter, LE1
Khalil-Boutros, Y1
Nefedev, A1
Kuhlmann, R1
Cohen, SM2
Misono, S2
Greene, SM1
Simpson, CB1
Norris, BK1
Schweinfurth, JM1
Birring, SS1
Lee, B1
Woo, P1
Persaud, R1
Frosh, A1
Mintz, S2
Lee, JK2
Mishriki, YY1

Reviews

8 reviews available for gabapentin and Cough

ArticleYear
Pharmacotherapeutic Options for Chronic Refractory Cough.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:11

    Topics: Analgesics, Opioid; Antitussive Agents; Chronic Disease; Cough; Gabapentin; Humans; Pyrimidines; Qua

2020
Management of chronic refractory cough in adults.
    European journal of internal medicine, 2020, Volume: 81

    Topics: Adult; Asthma; Chronic Disease; Cough; Gabapentin; Humans; Quality of Life

2020
A review on the efficacy and safety of gabapentin in the treatment of chronic cough.
    Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:1

    Topics: Amines; Antitussive Agents; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A

2015
Gabapentin in chronic cough.
    Pulmonary pharmacology & therapeutics, 2015, Volume: 35

    Topics: Amines; Animals; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagoni

2015
Management of chronic refractory cough.
    BMJ (Clinical research ed.), 2015, Dec-14, Volume: 351

    Topics: Adaptation, Psychological; Amines; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin;

2015
Are neuromodulating medications effective for the treatment of chronic neurogenic cough?
    The Laryngoscope, 2017, Volume: 127, Issue:5

    Topics: Amines; Amitriptyline; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob

2017
Evidence for sensory neuropathy and pharmacologic management.
    Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Amines; Amitriptyline; Anticonvulsants; Chronic Disease; Cough; Cycloh

2010
Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013, Volume: 148, Issue:3

    Topics: Amines; Amitriptyline; Baclofen; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; ga

2013

Trials

6 trials available for gabapentin and Cough

ArticleYear
The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial.
    Trials, 2022, Feb-21, Volume: 23, Issue:1

    Topics: Cough; Double-Blind Method; Gabapentin; Humans; Lung Diseases, Interstitial; Prospective Studies; Qu

2022
The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19- related cough: A randomized, controlled clinical trial.
    The clinical respiratory journal, 2022, Volume: 16, Issue:9

    Topics: Acetates; Cough; COVID-19; COVID-19 Drug Treatment; Cyclopropanes; Dextromethorphan; Gabapentin; Hum

2022
Letter to the editor regarding the study "The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19-related cough: A randomized, controlled clinical trial".
    The clinical respiratory journal, 2023, Volume: 17, Issue:2

    Topics: Cough; COVID-19; Dextromethorphan; Double-Blind Method; Gabapentin; Humans; Treatment Outcome

2023
Letter to the editor regarding the study "The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19-related cough: A randomized, controlled clinical trial".
    The clinical respiratory journal, 2023, Volume: 17, Issue:2

    Topics: Cough; COVID-19; Dextromethorphan; Double-Blind Method; Gabapentin; Humans; Treatment Outcome

2023
Letter to the editor regarding the study "The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19-related cough: A randomized, controlled clinical trial".
    The clinical respiratory journal, 2023, Volume: 17, Issue:2

    Topics: Cough; COVID-19; Dextromethorphan; Double-Blind Method; Gabapentin; Humans; Treatment Outcome

2023
Letter to the editor regarding the study "The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19-related cough: A randomized, controlled clinical trial".
    The clinical respiratory journal, 2023, Volume: 17, Issue:2

    Topics: Cough; COVID-19; Dextromethorphan; Double-Blind Method; Gabapentin; Humans; Treatment Outcome

2023
Reply to the letter to the editor regarding the study "The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19-related cough: A randomized, controlled clinical trial".
    The clinical respiratory journal, 2023, Volume: 17, Issue:6

    Topics: Cough; COVID-19; Dextromethorphan; Gabapentin; Humans

2023
Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough.
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:6

    Topics: Adult; Analgesics; Baclofen; Chronic Disease; Cough; Dose-Response Relationship, Drug; Female; Follo

2019
Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2012, Nov-03, Volume: 380, Issue:9853

    Topics: Adolescent; Adult; Amines; Anticonvulsants; Central Nervous System; Chronic Disease; Cough; Cyclohex

2012

Other Studies

17 other studies available for gabapentin and Cough

ArticleYear
[Guidelines for the management of chronic cough in adults].
    Revue des maladies respiratoires, 2023, Volume: 40, Issue:5

    Topics: Adult; Amitriptyline; Chronic Disease; Cough; Gabapentin; Humans; Quality of Life

2023
Gabapentin alleviated the cough hypersensitivity and neurogenic inflammation in a guinea pig model with repeated intra-esophageal acid perfusion.
    European journal of pharmacology, 2023, Nov-15, Volume: 959

    Topics: Animals; Cough; Gabapentin; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Lung; Neurogeni

2023
A cough that won't go away: Evaluation and treatment in 2 patients.
    Cleveland Clinic journal of medicine, 2020, Volume: 87, Issue:2

    Topics: Aged; Analgesics, Opioid; Botulinum Toxins; Chronic Disease; Cognitive Behavioral Therapy; Cough; Di

2020
Recurrent Henoch-Schönlein Purpura with bullous rash and pulmonary nodules.
    Pediatric rheumatology online journal, 2020, May-24, Volume: 18, Issue:1

    Topics: Biopsy, Fine-Needle; Bronchoalveolar Lavage Fluid; Chest Pain; Child; Complement C3; Cough; Female;

2020
Unilateral Laryngoscopic Findings Associated With Response to Gabapentin in Patients With Chronic Cough.
    JAMA otolaryngology-- head & neck surgery, 2017, 11-01, Volume: 143, Issue:11

    Topics: Amines; Calcium Channel Blockers; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Female; Gabap

2017
Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2018, Volume: 159, Issue:3

    Topics: Adult; Aged; Amitriptyline; Chronic Disease; Cohort Studies; Cough; Dose-Response Relationship, Drug

2018
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue? Authors' reply.
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:9

    Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents

2019
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue?
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:9

    Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents

2019
Gabapentin as a potential treatment for cough syncope.
    Respiratory care, 2015, Volume: 60, Issue:2

    Topics: Amines; Antitussive Agents; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A

2015
[On the Differential Diagnosis of Intractable Psychogenic Chronic Cough: Neuropathic Larynx Irritable - Gabapentin's Antitussive Action].
    Fortschritte der Neurologie-Psychiatrie, 2015, Volume: 83, Issue:10

    Topics: Aged; Amines; Avitaminosis; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Depressive Disorder

2015
Management of recurrent laryngeal sensory neuropathic symptoms.
    The Annals of otology, rhinology, and laryngology, 2010, Volume: 119, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Aged; Amines; Amitriptyline; Cough; Cranial Nerve Diseases; Cyclohexan

2010
Gabapentin: a suppressant for refractory chronic cough.
    Lancet (London, England), 2012, Nov-03, Volume: 380, Issue:9853

    Topics: Amines; Cough; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Mal

2012
Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment.
    The Annals of otology, rhinology, and laryngology, 2005, Volume: 114, Issue:4

    Topics: Adolescent; Adult; Aged; Amines; Analgesics; Cough; Cyclohexanecarboxylic Acids; Deglutition Disorde

2005
The aetiology of chronic cough: a review of current theories for the otorhinolaryngologists.
    The Journal of laryngology and otology, 2006, Volume: 120, Issue:2

    Topics: Amines; Anticonvulsants; Chronic Disease; Cough; Cranial Nerve Diseases; Cyclohexanecarboxylic Acids

2006
Gabapentin in the treatment of intractable idiopathic chronic cough: case reports.
    The American journal of medicine, 2006, Volume: 119, Issue:5

    Topics: Adult; Aged; Amines; Calcium Channel Blockers; Chronic Disease; Cough; Cyclohexanecarboxylic Acids;

2006
Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment.
    The Annals of otology, rhinology, and laryngology, 2006, Volume: 115, Issue:11

    Topics: Amines; Chronic Disease; Cough; Cranial Nerve Diseases; Cyclohexanecarboxylic Acids; Diagnosis, Diff

2006
Laryngeal neuropathy as a cause of chronic intractable cough.
    The American journal of medicine, 2007, Volume: 120, Issue:2

    Topics: Amines; Cough; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Ami

2007