Page last updated: 2024-10-27

flutamide and Sepsis

flutamide has been researched along with Sepsis in 2 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"To determine whether treatment with an androgen receptor blocker (eg, flutamide) after trauma-hemorrhage and sepsis has any salutary effects on cell-mediated immunity and on the survival of male animals under those conditions."3.69Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997)
"The clinical course after multiple trauma depends on the balance or imbalance of the pro- and anti-inflammatory immune response."2.47Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand? ( Andruszkow, H; Frink, M; Hildebrand, F; Krettek, C; Mommsen, P; Neunaber, C; Zeckey, C, 2011)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Neunaber, C1
Zeckey, C1
Andruszkow, H1
Frink, M1
Mommsen, P1
Krettek, C1
Hildebrand, F1
Angele, MK1
Wichmann, MW1
Ayala, A1
Cioffi, WG1
Chaudry, IH1

Reviews

1 review available for flutamide and Sepsis

ArticleYear
Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand?
    Recent patents on inflammation & allergy drug discovery, 2011, Volume: 5, Issue:1

    Topics: Androstenediol; Animals; Dehydroepiandrosterone; Finasteride; Flutamide; Humans; Immunomodulation; L

2011

Other Studies

1 other study available for flutamide and Sepsis

ArticleYear
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1997, Volume: 132, Issue:11

    Topics: Androgen Antagonists; Animals; Flutamide; Hemorrhage; Immunity, Cellular; Interleukins; Male; Mice;

1997