Page last updated: 2024-10-27

flutamide and Acne

flutamide has been researched along with Acne in 23 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Research Excerpts

ExcerptRelevanceReference
" All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels."9.12Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007)
"Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function."9.08Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995)
"The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated."7.77Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011)
"The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception."7.74[Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008)
" In Group 2, clinical improvement of acne was achieved by flutamide alone without alteration in circulating androgens (including T, A, and DHEA-S)."7.70Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. ( Soong, YK; Wang, HS; Wang, TH, 1999)
"Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation."7.68The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993)
"Hyperandrogenism is a condition affecting 5-10% of adolescents."5.48Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018)
" All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels."5.12Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007)
"To compare the relative effectiveness of two newer antiandrogens (flutamide and finasteride) with cyproterone acetate (CPA), at both low and high doses in the treatment of moderate to severe acne in hyperandrogenic women."5.10A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. ( Carmina, E; Lobo, RA, 2002)
"Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function."5.08Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995)
"English-language controlled clinical trials of systemic hormonal treatment of acne were sought by search of references of general dermatology texts, reviews on acne, drug product monographs, and computer-assisted search of MEDLINE, CINAHL, and COCHRANE databases between 1970 and 2003 using the key words hormonal, oral contraceptive, acne, spironolactone, cyproterone, flutamide, and therapy."4.82Hormonal treatment of acne: review of current best evidence. ( Tan, J, 2004)
"The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated."3.77Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011)
"The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception."3.74[Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008)
" In Group 2, clinical improvement of acne was achieved by flutamide alone without alteration in circulating androgens (including T, A, and DHEA-S)."3.70Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. ( Soong, YK; Wang, HS; Wang, TH, 1999)
"Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation."3.68The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993)
"Flutamide treatment determined a clinical, marked improvement of androgen hypersensitivity (Ferriman-Gallwey score: before 22."2.68Androgen-receptor blockade does not impair bone mineral density in adolescent females. ( Baroncelli, GI; Battini, R; Bertelloni, S; Costa, S; Saggese, G; Sorrentino, MC, 1997)
"Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat."2.48Acne in the adult female patient: a practical approach. ( Kamangar, F; Shinkai, K, 2012)
"Acne affects more than 40 million people, of which more than half are women older than 25 years of age."2.44Hormonal therapy for acne. ( Clarke, S; George, R; Thiboutot, D, 2008)
"Hyperandrogenism is a condition affecting 5-10% of adolescents."1.48Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.04)18.7374
1990's6 (26.09)18.2507
2000's7 (30.43)29.6817
2010's7 (30.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fulghesu, AM1
Melis, F1
Murru, G1
Canu, E1
Melis, GB1
Azarchi, S1
Bienenfeld, A1
Lo Sicco, K1
Marchbein, S1
Shapiro, J1
Nagler, AR1
Buzney, E1
Sheu, J1
Buzney, C1
Reynolds, RV1
Bettoli, V1
Zauli, S1
Virgili, A1
Hassoun, LA1
Chahal, DS1
Sivamani, RK1
Larsen, LN1
George, R1
Clarke, S1
Thiboutot, D1
Pizzo, A1
Borrielli, I1
Mastroeni, MT1
Fattori, A1
Dugo, C1
Dugo, N1
Dinatale, A1
Paradisi, R1
Fabbri, R1
Porcu, E1
Battaglia, C1
Seracchioli, R1
Venturoli, S1
Kamangar, F1
Shinkai, K1
Carmina, E1
Lobo, RA1
Tan, J1
Haroun, M1
Calaf, J1
López, E1
Millet, A1
Alcañiz, J1
Fortuny, A1
Vidal, O1
Callejo, J1
Escobar-Jiménez, F1
Torres, E1
Espinós, JJ1
Lyons, F1
Shuster, S2
Rees, J1
Moghetti, P1
Castello, R1
Negri, C1
Tosi, F1
Magnani, CM1
Fontanarosa, MC1
Armanini, D1
Muggeo, M1
Couzinet, B1
Pholsena, M1
Young, J1
Schaison, G1
Bertelloni, S1
Baroncelli, GI1
Sorrentino, MC1
Costa, S1
Battini, R1
Saggese, G1
Schmidt, JB1
Wang, HS1
Wang, TH1
Soong, YK1
Drapier-Faure, E1
Faure, M1
Neri, RO1
Sciarra, F1
Toscano, V1
Concolino, G1
Di Silverio, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967]Phase 430 participants (Anticipated)Interventional2021-04-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for flutamide and Acne

ArticleYear
Androgens in women: Hormone-modulating therapies for skin disease.
    Journal of the American Academy of Dermatology, 2019, Volume: 80, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Alopecia; Androgen Ant

2019
Polycystic ovary syndrome: a review for dermatologists: Part II. Treatment.
    Journal of the American Academy of Dermatology, 2014, Volume: 71, Issue:5

    Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Contraceptives, Oral, C

2014
Is hormonal treatment still an option in acne today?
    The British journal of dermatology, 2015, Volume: 172 Suppl 1

    Topics: Acne Vulgaris; Adrenal Cortex Hormones; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal;

2015
The use of hormonal agents in the treatment of acne.
    Seminars in cutaneous medicine and surgery, 2016, Volume: 35, Issue:2

    Topics: Acne Vulgaris; Administration, Oral; Contraceptive Agents; Cortodoxone; Cyproterone Acetate; Dermato

2016
Hormonal therapy for acne.
    Seminars in cutaneous medicine and surgery, 2008, Volume: 27, Issue:3

    Topics: Acne Vulgaris; Androgen Antagonists; Contraceptives, Oral; Cyproterone Acetate; Female; Flutamide; H

2008
Acne in the adult female patient: a practical approach.
    International journal of dermatology, 2012, Volume: 51, Issue:10

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatologic

2012
Hormonal treatment of acne: review of current best evidence.
    Journal of cutaneous medicine and surgery, 2004, Volume: 8 Suppl 4

    Topics: Acne Vulgaris; Androgen Antagonists; Contraceptives, Oral, Hormonal; Female; Flutamide; Humans; Male

2004
Hormonal therapy of acne.
    Journal of cutaneous medicine and surgery, 2004, Volume: 8 Suppl 4

    Topics: Acne Vulgaris; Adult; Androgen Antagonists; Androgens; Contraceptives, Oral, Hormonal; Cyproterone A

2004
[What is the role of hormonal treatments in acne?].
    Annales de dermatologie et de venereologie, 2001, Volume: 128 Supp 1

    Topics: Acne Vulgaris; Androgen Antagonists; Cyproterone; Estrogens; Flutamide; Glucocorticoids; Hormone Ant

2001
Antiandrogens.
    Advances in sex hormone research, 1976, Volume: 2

    Topics: Acne Vulgaris; Androgen Antagonists; Animals; Biological Assay; Comb and Wattles; Cyproterone; Femal

1976

Trials

5 trials available for flutamide and Acne

ArticleYear
A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women.
    Clinical endocrinology, 2002, Volume: 57, Issue:2

    Topics: Acne Vulgaris; Adult; Androgen Antagonists; Cyproterone Acetate; Drug Administration Schedule; Femal

2002
Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:9

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatitis,

2007
Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
    Fertility and sterility, 1995, Volume: 64, Issue:3

    Topics: Acne Vulgaris; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal

1995
Androgen-receptor blockade does not impair bone mineral density in adolescent females.
    Calcified tissue international, 1997, Volume: 61, Issue:1

    Topics: Absorptiometry, Photon; Acne Vulgaris; Adolescent; Adult; Analysis of Variance; Androgen Antagonists

1997
Antiandrogens: clinical applications.
    The Journal of steroid biochemistry and molecular biology, 1990, Nov-20, Volume: 37, Issue:3

    Topics: Acne Vulgaris; Adult; Androgen Antagonists; Cyproterone; Cyproterone Acetate; Dermatitis, Seborrheic

1990

Other Studies

8 other studies available for flutamide and Acne

ArticleYear
Very low dose of flutamide in the treatment of hyperandrogenism.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2018, Volume: 34, Issue:5

    Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Androstenes; Dose-Response Relationship, Drug; Drug

2018
[Low-dose flutamide in the treatment of hyperandrogenism in adolescents].
    Minerva pediatrica, 2008, Volume: 60, Issue:6

    Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Body Mass Index; Child; Female; Flutamide; Follow-U

2008
Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:10

    Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cont

2011
Sex difference in response of the human sebaceous gland to topical flutamide.
    The British journal of dermatology, 1982, Volume: 107, Issue:6

    Topics: Acne Vulgaris; Adolescent; Anilides; Female; Flutamide; Humans; Male; Sebum; Secretory Rate; Sex Fac

1982
Pubertal induction of sweat gland activity.
    Clinical science (London, England : 1979), 1981, Volume: 60, Issue:6

    Topics: Acne Vulgaris; Adult; Child; Cyproterone; Cyproterone Acetate; Female; Flutamide; Humans; Male; Midd

1981
The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism.
    Clinical endocrinology, 1993, Volume: 39, Issue:2

    Topics: Acne Vulgaris; Adult; Androgens; Dermatitis, Seborrheic; Female; Flutamide; Follicle Stimulating Hor

1993
Other antiandrogens.
    Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:1

    Topics: Acne Vulgaris; Androgen Antagonists; Cimetidine; Female; Finasteride; Flutamide; Humans; Isotretinoi

1998
Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea.
    Changgeng yi xue za zhi, 1999, Volume: 22, Issue:3

    Topics: Acne Vulgaris; Adult; Amenorrhea; Androgen Antagonists; Estrogens; Female; Flutamide; Humans; Lutein

1999