flutamide has been researched along with Acne in 23 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels." | 9.12 | Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007) |
| "Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function." | 9.08 | Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995) |
| "The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated." | 7.77 | Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011) |
| "The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception." | 7.74 | [Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008) |
| " In Group 2, clinical improvement of acne was achieved by flutamide alone without alteration in circulating androgens (including T, A, and DHEA-S)." | 7.70 | Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. ( Soong, YK; Wang, HS; Wang, TH, 1999) |
| "Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation." | 7.68 | The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993) |
| "Hyperandrogenism is a condition affecting 5-10% of adolescents." | 5.48 | Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018) |
| " All flutamide doses induced a significant decrease in hirsutism, acne, and seborrhea scores after 12 months compared with placebo without differences among dose levels." | 5.12 | Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial. ( Alcañiz, J; Calaf, J; Callejo, J; Escobar-Jiménez, F; Espinós, JJ; Fortuny, A; López, E; Millet, A; Torres, E; Vidal, O, 2007) |
| "To compare the relative effectiveness of two newer antiandrogens (flutamide and finasteride) with cyproterone acetate (CPA), at both low and high doses in the treatment of moderate to severe acne in hyperandrogenic women." | 5.10 | A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. ( Carmina, E; Lobo, RA, 2002) |
| "Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function." | 5.08 | Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior. ( Armanini, D; Castello, R; Fontanarosa, MC; Magnani, CM; Moghetti, P; Muggeo, M; Negri, C; Tosi, F, 1995) |
| "English-language controlled clinical trials of systemic hormonal treatment of acne were sought by search of references of general dermatology texts, reviews on acne, drug product monographs, and computer-assisted search of MEDLINE, CINAHL, and COCHRANE databases between 1970 and 2003 using the key words hormonal, oral contraceptive, acne, spironolactone, cyproterone, flutamide, and therapy." | 4.82 | Hormonal treatment of acne: review of current best evidence. ( Tan, J, 2004) |
| "The long-term effects and tolerability of flutamide (Flu) in women with acne and seborrhea were evaluated." | 3.77 | Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period. ( Battaglia, C; Fabbri, R; Paradisi, R; Porcu, E; Seracchioli, R; Venturoli, S, 2011) |
| "The authors hope that flutamide could enter in the list of medicines normally used to treat the beauty flaws of policistic acne and to restore a hormonal order associated to an effective contraception." | 3.74 | [Low-dose flutamide in the treatment of hyperandrogenism in adolescents]. ( Borrielli, I; Dinatale, A; Dugo, C; Dugo, N; Fattori, A; Mastroeni, MT; Pizzo, A, 2008) |
| " In Group 2, clinical improvement of acne was achieved by flutamide alone without alteration in circulating androgens (including T, A, and DHEA-S)." | 3.70 | Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea. ( Soong, YK; Wang, HS; Wang, TH, 1999) |
| "Flutamide, which interacts only with the androgen receptor, is effective for hirsutism, acne and seborrhoea, and does not disturb menstrual cyclicity or ovulation." | 3.68 | The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism. ( Couzinet, B; Pholsena, M; Schaison, G; Young, J, 1993) |
| "Flutamide treatment determined a clinical, marked improvement of androgen hypersensitivity (Ferriman-Gallwey score: before 22." | 2.68 | Androgen-receptor blockade does not impair bone mineral density in adolescent females. ( Baroncelli, GI; Battini, R; Bertelloni, S; Costa, S; Saggese, G; Sorrentino, MC, 1997) |
| "Acne vulgaris is a common reason why adult women present to dermatologists and can be a clinical challenge to treat." | 2.48 | Acne in the adult female patient: a practical approach. ( Kamangar, F; Shinkai, K, 2012) |
| "Acne affects more than 40 million people, of which more than half are women older than 25 years of age." | 2.44 | Hormonal therapy for acne. ( Clarke, S; George, R; Thiboutot, D, 2008) |
| "Hyperandrogenism is a condition affecting 5-10% of adolescents." | 1.48 | Very low dose of flutamide in the treatment of hyperandrogenism. ( Canu, E; Fulghesu, AM; Melis, F; Melis, GB; Murru, G, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fulghesu, AM | 1 |
| Melis, F | 1 |
| Murru, G | 1 |
| Canu, E | 1 |
| Melis, GB | 1 |
| Azarchi, S | 1 |
| Bienenfeld, A | 1 |
| Lo Sicco, K | 1 |
| Marchbein, S | 1 |
| Shapiro, J | 1 |
| Nagler, AR | 1 |
| Buzney, E | 1 |
| Sheu, J | 1 |
| Buzney, C | 1 |
| Reynolds, RV | 1 |
| Bettoli, V | 1 |
| Zauli, S | 1 |
| Virgili, A | 1 |
| Hassoun, LA | 1 |
| Chahal, DS | 1 |
| Sivamani, RK | 1 |
| Larsen, LN | 1 |
| George, R | 1 |
| Clarke, S | 1 |
| Thiboutot, D | 1 |
| Pizzo, A | 1 |
| Borrielli, I | 1 |
| Mastroeni, MT | 1 |
| Fattori, A | 1 |
| Dugo, C | 1 |
| Dugo, N | 1 |
| Dinatale, A | 1 |
| Paradisi, R | 1 |
| Fabbri, R | 1 |
| Porcu, E | 1 |
| Battaglia, C | 1 |
| Seracchioli, R | 1 |
| Venturoli, S | 1 |
| Kamangar, F | 1 |
| Shinkai, K | 1 |
| Carmina, E | 1 |
| Lobo, RA | 1 |
| Tan, J | 1 |
| Haroun, M | 1 |
| Calaf, J | 1 |
| López, E | 1 |
| Millet, A | 1 |
| Alcañiz, J | 1 |
| Fortuny, A | 1 |
| Vidal, O | 1 |
| Callejo, J | 1 |
| Escobar-Jiménez, F | 1 |
| Torres, E | 1 |
| Espinós, JJ | 1 |
| Lyons, F | 1 |
| Shuster, S | 2 |
| Rees, J | 1 |
| Moghetti, P | 1 |
| Castello, R | 1 |
| Negri, C | 1 |
| Tosi, F | 1 |
| Magnani, CM | 1 |
| Fontanarosa, MC | 1 |
| Armanini, D | 1 |
| Muggeo, M | 1 |
| Couzinet, B | 1 |
| Pholsena, M | 1 |
| Young, J | 1 |
| Schaison, G | 1 |
| Bertelloni, S | 1 |
| Baroncelli, GI | 1 |
| Sorrentino, MC | 1 |
| Costa, S | 1 |
| Battini, R | 1 |
| Saggese, G | 1 |
| Schmidt, JB | 1 |
| Wang, HS | 1 |
| Wang, TH | 1 |
| Soong, YK | 1 |
| Drapier-Faure, E | 1 |
| Faure, M | 1 |
| Neri, RO | 1 |
| Sciarra, F | 1 |
| Toscano, V | 1 |
| Concolino, G | 1 |
| Di Silverio, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for flutamide and Acne
| Article | Year |
|---|---|
Androgens in women: Hormone-modulating therapies for skin disease.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Alopecia; Androgen Ant | 2019 |
Polycystic ovary syndrome: a review for dermatologists: Part II. Treatment.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Contraceptives, Oral, C | 2014 |
Is hormonal treatment still an option in acne today?
Topics: Acne Vulgaris; Adrenal Cortex Hormones; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; | 2015 |
The use of hormonal agents in the treatment of acne.
Topics: Acne Vulgaris; Administration, Oral; Contraceptive Agents; Cortodoxone; Cyproterone Acetate; Dermato | 2016 |
Hormonal therapy for acne.
Topics: Acne Vulgaris; Androgen Antagonists; Contraceptives, Oral; Cyproterone Acetate; Female; Flutamide; H | 2008 |
Acne in the adult female patient: a practical approach.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatologic | 2012 |
Hormonal treatment of acne: review of current best evidence.
Topics: Acne Vulgaris; Androgen Antagonists; Contraceptives, Oral, Hormonal; Female; Flutamide; Humans; Male | 2004 |
Hormonal therapy of acne.
Topics: Acne Vulgaris; Adult; Androgen Antagonists; Androgens; Contraceptives, Oral, Hormonal; Cyproterone A | 2004 |
[What is the role of hormonal treatments in acne?].
Topics: Acne Vulgaris; Androgen Antagonists; Cyproterone; Estrogens; Flutamide; Glucocorticoids; Hormone Ant | 2001 |
Antiandrogens.
Topics: Acne Vulgaris; Androgen Antagonists; Animals; Biological Assay; Comb and Wattles; Cyproterone; Femal | 1976 |
5 trials available for flutamide and Acne
| Article | Year |
|---|---|
A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women.
Topics: Acne Vulgaris; Adult; Androgen Antagonists; Cyproterone Acetate; Drug Administration Schedule; Femal | 2002 |
Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Contraceptives, Oral, Hormonal; Dermatitis, | 2007 |
Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
Topics: Acne Vulgaris; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal | 1995 |
Androgen-receptor blockade does not impair bone mineral density in adolescent females.
Topics: Absorptiometry, Photon; Acne Vulgaris; Adolescent; Adult; Analysis of Variance; Androgen Antagonists | 1997 |
Antiandrogens: clinical applications.
Topics: Acne Vulgaris; Adult; Androgen Antagonists; Cyproterone; Cyproterone Acetate; Dermatitis, Seborrheic | 1990 |
8 other studies available for flutamide and Acne
| Article | Year |
|---|---|
Very low dose of flutamide in the treatment of hyperandrogenism.
Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Androstenes; Dose-Response Relationship, Drug; Drug | 2018 |
[Low-dose flutamide in the treatment of hyperandrogenism in adolescents].
Topics: Acne Vulgaris; Adolescent; Androgen Antagonists; Body Mass Index; Child; Female; Flutamide; Follow-U | 2008 |
Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year period.
Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Chemical and Drug Induced Liver Injury; Cont | 2011 |
Sex difference in response of the human sebaceous gland to topical flutamide.
Topics: Acne Vulgaris; Adolescent; Anilides; Female; Flutamide; Humans; Male; Sebum; Secretory Rate; Sex Fac | 1982 |
Pubertal induction of sweat gland activity.
Topics: Acne Vulgaris; Adult; Child; Cyproterone; Cyproterone Acetate; Female; Flutamide; Humans; Male; Midd | 1981 |
The impact of a pure anti-androgen (flutamide) on LH, FSH, androgens and clinical status in idiopathic hirsutism.
Topics: Acne Vulgaris; Adult; Androgens; Dermatitis, Seborrheic; Female; Flutamide; Follicle Stimulating Hor | 1993 |
Other antiandrogens.
Topics: Acne Vulgaris; Androgen Antagonists; Cimetidine; Female; Finasteride; Flutamide; Humans; Isotretinoi | 1998 |
Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea.
Topics: Acne Vulgaris; Adult; Amenorrhea; Androgen Antagonists; Estrogens; Female; Flutamide; Humans; Lutein | 1999 |