fentanyl and Sepsis
fentanyl has been researched along with Sepsis in 16 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables." | 9.51 | Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022) |
| "To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables." | 5.51 | Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022) |
| " Emergency surgery, more doses of midazolam, and fentanyl may be independent risk factors for SAD in mechanically ventilated patients with sepsis." | 5.34 | Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial. ( Kawazoe, Y; Miyamoto, K; Mizobata, Y; Morimoto, T; Ohta, Y; Yamamoto, T; Yamamura, H, 2020) |
| " In this study, the effects of propofol in healthy and in septic sheep, and in combination with fentanyl, were analyzed and compared with nonanesthetized septic sheep." | 1.29 | The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep. ( Armstrong, C; Booke, M; Conroy, B; Hinder, F; Traber, DL; Traber, LD, 1996) |
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Nagashima, JK | 1 |
| Gonçalves, LA | 1 |
| Pereira, MA | 1 |
| Talib, MS | 1 |
| de Olveira, CM | 1 |
| Ambrósio, AM | 1 |
| Fantoni, DT | 1 |
| Yamamoto, T | 1 |
| Mizobata, Y | 1 |
| Kawazoe, Y | 1 |
| Miyamoto, K | 1 |
| Ohta, Y | 1 |
| Morimoto, T | 1 |
| Yamamura, H | 1 |
| Polok, KJ | 1 |
| Nowak-Kózka, I | 1 |
| Fronczek, J | 1 |
| Szczeklik, W | 1 |
| Finsterer, J | 1 |
| Dumser, M | 1 |
| Quintin, L | 1 |
| Hoemberg, M | 1 |
| Vierzig, A | 1 |
| Roth, B | 1 |
| Eifinger, F | 1 |
| Nardi, GM | 1 |
| Bet, AC | 1 |
| Sordi, R | 1 |
| Fernandes, D | 1 |
| Assreuy, J | 1 |
| Carter, AC | 1 |
| Nicholas, JJ | 1 |
| Bollen, PJ | 1 |
| Nielsen, BJ | 1 |
| Toft, P | 1 |
| Rietbrock, I | 1 |
| Booke, M | 1 |
| Armstrong, C | 1 |
| Hinder, F | 1 |
| Conroy, B | 1 |
| Traber, LD | 1 |
| Traber, DL | 1 |
| Borghans, JG | 2 |
| Hosli, MT | 1 |
| Olsen, H | 2 |
| Ravn, EM | 1 |
| Siboni, K | 2 |
| Søgaard, P | 2 |
| Ravn, E | 1 |
| Hjorth, A | 1 |
| Nielsen, KN | 1 |
| Askgaard, K | 1 |
| Secher, B | 1 |
| Borghans, J | 1 |
| Khing-Ting, L | 1 |
| Joosten, H | 1 |
| Frederiksen, W | 1 |
| Jensen, K | 1 |
| Mortensen, N | 1 |
| Sebbesen, O | 1 |
| Clasener, HA | 1 |
| Wakkerman, PM | 1 |
| Woldring-Zwaan, C | 1 |
| Joosten, HJ | 1 |
| Holst, MT | 1 |
| Maki, DG | 1 |
| Klein, BS | 1 |
| McCormick, RD | 1 |
| Alvarado, CJ | 1 |
| Zilz, MA | 1 |
| Stolz, SM | 1 |
| Hassemer, CA | 1 |
| Gould, J | 1 |
| Liegel, AR | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modified Hospital Elder Life Program at Intensive Care Unit: A Stepped-Wedge Cluster Randomized Controlled Trial[NCT06054828] | 266 participants (Anticipated) | Interventional | 2023-09-05 | Recruiting | |||
| A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238] | Phase 3 | 97 participants (Actual) | Interventional | 2021-01-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for fentanyl and Sepsis
| Article | Year |
|---|---|
[Altered pharmacokinetics of anaesthetic agents in liver disease during anaesthesia and surgery and intensive-care treatment (author's transl)].
Topics: Anesthetics; Critical Care; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Hexobarbital | 1980 |
Trials
2 trials available for fentanyl and Sepsis
| Article | Year |
|---|---|
Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Dexmedetomidine; Dog Diseases; Dogs; Female; Fentanyl; | 2022 |
Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial.
Topics: Aged; Aged, 80 and over; Critical Care; Delirium; Female; Fentanyl; Hospital Mortality; Humans; Hypn | 2020 |
Other Studies
13 other studies available for fentanyl and Sepsis
| Article | Year |
|---|---|
Concentrations of fentanyl before and after initiation of continuous venovenous haemodialysis in septic patients with acute kidney injury: A prospective observational study.
Topics: Acute Kidney Injury; Continuous Renal Replacement Therapy; Fentanyl; Humans; Prospective Studies; Se | 2021 |
Allergy to transdermal fentanyl resulting in Staphylococcus aureus sepsis and fatal endocarditis with myocardial rupture.
Topics: Administration, Cutaneous; Aged, 80 and over; Drug Eruptions; Echocardiography, Transesophageal; End | 2016 |
Alpha-2 adrenoceptor agonists and sepsis: improved survival?
Topics: Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Fentanyl; Humans; Sepsis; Survival Analysis | 2010 |
Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy.
Topics: Anesthetics, Inhalation; Child, Preschool; Conscious Sedation; Fentanyl; Fluorides; Humans; Hypnotic | 2012 |
Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
Topics: Analgesics, Opioid; Animals; Biochemical Phenomena; Body Temperature; Body Weight; Cardiovascular Sy | 2013 |
The importance of the complete history in the discovery of a potential suicide: a case report.
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Bacterial Agents; Cyclohexanecarboxy | 2003 |
Influence of endotoxin-induced sepsis on the requirements of propofol-fentanyl infusion rate in pigs.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Endotoxins; Fentanyl; Infusions, Intrave | 2007 |
The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep.
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Fentanyl; Hemodynamics; Kidney; Oxygen; Pr | 1996 |
Pseudomonas cepacia bacteraemia due to intrinsic contamination of an anaesthetic. Bacteriological and serological observations.
Topics: Anesthetics; Antibodies, Bacterial; Antigens, Bacterial; Bacteriological Techniques; Benzoates; Denm | 1979 |
Pseudomonas cepacia in 16 non-fatal cases of postoperative bacteremia derived from intrinsic contamination of the anaesthetic fentanyl. Clinical and epidemiological observations in Denmark and Holland.
Topics: Adult; Aged; Anesthesia, Intravenous; Antibodies, Bacterial; Blood; Child; Denmark; Drug Contaminati | 1979 |
[Pseudomonas cepacia bacteremia caused by intravenously administered fentanyl].
Topics: Drug Contamination; Fentanyl; Humans; Injections, Intravenous; Pseudomonas Infections; Sepsis | 1979 |
[Pseudomonas cepacia bacteremia caused by intravenously administered fentanyl].
Topics: Adolescent; Adult; Aged; Child; Female; Fentanyl; Humans; Injections, Intravenous; Male; Middle Aged | 1978 |
Nosocomial Pseudomonas pickettii bacteremias traced to narcotic tampering. A case for selective drug screening of health care personnel.
Topics: Adult; Case-Control Studies; Crime; Cross Infection; Disease Outbreaks; Fentanyl; Humans; Infusions, | 1991 |