Page last updated: 2024-10-27

fentanyl and Sepsis

fentanyl has been researched along with Sepsis in 16 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables."9.51Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022)
"To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables."5.51Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022)
" Emergency surgery, more doses of midazolam, and fentanyl may be independent risk factors for SAD in mechanically ventilated patients with sepsis."5.34Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial. ( Kawazoe, Y; Miyamoto, K; Mizobata, Y; Morimoto, T; Ohta, Y; Yamamoto, T; Yamamura, H, 2020)
" In this study, the effects of propofol in healthy and in septic sheep, and in combination with fentanyl, were analyzed and compared with nonanesthetized septic sheep."1.29The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep. ( Armstrong, C; Booke, M; Conroy, B; Hinder, F; Traber, DL; Traber, LD, 1996)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's2 (12.50)18.2507
2000's2 (12.50)29.6817
2010's4 (25.00)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Nagashima, JK1
Gonçalves, LA1
Pereira, MA1
Talib, MS1
de Olveira, CM1
Ambrósio, AM1
Fantoni, DT1
Yamamoto, T1
Mizobata, Y1
Kawazoe, Y1
Miyamoto, K1
Ohta, Y1
Morimoto, T1
Yamamura, H1
Polok, KJ1
Nowak-Kózka, I1
Fronczek, J1
Szczeklik, W1
Finsterer, J1
Dumser, M1
Quintin, L1
Hoemberg, M1
Vierzig, A1
Roth, B1
Eifinger, F1
Nardi, GM1
Bet, AC1
Sordi, R1
Fernandes, D1
Assreuy, J1
Carter, AC1
Nicholas, JJ1
Bollen, PJ1
Nielsen, BJ1
Toft, P1
Rietbrock, I1
Booke, M1
Armstrong, C1
Hinder, F1
Conroy, B1
Traber, LD1
Traber, DL1
Borghans, JG2
Hosli, MT1
Olsen, H2
Ravn, EM1
Siboni, K2
Søgaard, P2
Ravn, E1
Hjorth, A1
Nielsen, KN1
Askgaard, K1
Secher, B1
Borghans, J1
Khing-Ting, L1
Joosten, H1
Frederiksen, W1
Jensen, K1
Mortensen, N1
Sebbesen, O1
Clasener, HA1
Wakkerman, PM1
Woldring-Zwaan, C1
Joosten, HJ1
Holst, MT1
Maki, DG1
Klein, BS1
McCormick, RD1
Alvarado, CJ1
Zilz, MA1
Stolz, SM1
Hassemer, CA1
Gould, J1
Liegel, AR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Modified Hospital Elder Life Program at Intensive Care Unit: A Stepped-Wedge Cluster Randomized Controlled Trial[NCT06054828]266 participants (Anticipated)Interventional2023-09-05Recruiting
A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238]Phase 397 participants (Actual)Interventional2021-01-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fentanyl and Sepsis

ArticleYear
[Altered pharmacokinetics of anaesthetic agents in liver disease during anaesthesia and surgery and intensive-care treatment (author's transl)].
    Der Anaesthesist, 1980, Volume: 29, Issue:8

    Topics: Anesthetics; Critical Care; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Hexobarbital

1980

Trials

2 trials available for fentanyl and Sepsis

ArticleYear
Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study.
    Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:6

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Dexmedetomidine; Dog Diseases; Dogs; Female; Fentanyl;

2022
Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial.
    Journal of critical care, 2020, Volume: 56

    Topics: Aged; Aged, 80 and over; Critical Care; Delirium; Female; Fentanyl; Hospital Mortality; Humans; Hypn

2020

Other Studies

13 other studies available for fentanyl and Sepsis

ArticleYear
Concentrations of fentanyl before and after initiation of continuous venovenous haemodialysis in septic patients with acute kidney injury: A prospective observational study.
    European journal of anaesthesiology, 2021, 06-01, Volume: 38, Issue:6

    Topics: Acute Kidney Injury; Continuous Renal Replacement Therapy; Fentanyl; Humans; Prospective Studies; Se

2021
Allergy to transdermal fentanyl resulting in Staphylococcus aureus sepsis and fatal endocarditis with myocardial rupture.
    Medecine et maladies infectieuses, 2016, Volume: 46, Issue:4

    Topics: Administration, Cutaneous; Aged, 80 and over; Drug Eruptions; Echocardiography, Transesophageal; End

2016
Alpha-2 adrenoceptor agonists and sepsis: improved survival?
    Critical care (London, England), 2010, Volume: 14, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Fentanyl; Humans; Sepsis; Survival Analysis

2010
Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:4

    Topics: Anesthetics, Inhalation; Child, Preschool; Conscious Sedation; Fentanyl; Fluorides; Humans; Hypnotic

2012
Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:4

    Topics: Analgesics, Opioid; Animals; Biochemical Phenomena; Body Temperature; Body Weight; Cardiovascular Sy

2013
The importance of the complete history in the discovery of a potential suicide: a case report.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:3

    Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Bacterial Agents; Cyclohexanecarboxy

2003
Influence of endotoxin-induced sepsis on the requirements of propofol-fentanyl infusion rate in pigs.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:3

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Endotoxins; Fentanyl; Infusions, Intrave

2007
The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:4

    Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Fentanyl; Hemodynamics; Kidney; Oxygen; Pr

1996
Pseudomonas cepacia bacteraemia due to intrinsic contamination of an anaesthetic. Bacteriological and serological observations.
    Acta pathologica et microbiologica Scandinavica. Section B, Microbiology, 1979, Volume: 87B, Issue:1

    Topics: Anesthetics; Antibodies, Bacterial; Antigens, Bacterial; Bacteriological Techniques; Benzoates; Denm

1979
Pseudomonas cepacia in 16 non-fatal cases of postoperative bacteremia derived from intrinsic contamination of the anaesthetic fentanyl. Clinical and epidemiological observations in Denmark and Holland.
    Scandinavian journal of infectious diseases, 1979, Volume: 11, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Antibodies, Bacterial; Blood; Child; Denmark; Drug Contaminati

1979
[Pseudomonas cepacia bacteremia caused by intravenously administered fentanyl].
    Nederlands tijdschrift voor geneeskunde, 1979, Jul-07, Volume: 123, Issue:27

    Topics: Drug Contamination; Fentanyl; Humans; Injections, Intravenous; Pseudomonas Infections; Sepsis

1979
[Pseudomonas cepacia bacteremia caused by intravenously administered fentanyl].
    Nederlands tijdschrift voor geneeskunde, 1978, Nov-04, Volume: 122, Issue:44

    Topics: Adolescent; Adult; Aged; Child; Female; Fentanyl; Humans; Injections, Intravenous; Male; Middle Aged

1978
Nosocomial Pseudomonas pickettii bacteremias traced to narcotic tampering. A case for selective drug screening of health care personnel.
    JAMA, 1991, Feb-27, Volume: 265, Issue:8

    Topics: Adult; Case-Control Studies; Crime; Cross Infection; Disease Outbreaks; Fentanyl; Humans; Infusions,

1991