fentanyl and Pain
fentanyl has been researched along with Pain in 1200 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "This study aimed to compare the efficacy of intravenous, intranasal fentanyl and oral sucrose in reducing the pain response during retinopathy of prematurity examinations using premature infant pain profile (PIPP) scores." | 9.69 | Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial. ( Arman, D; Cömert, S; Gül, A; Kara, N; Seymen, Z, 2023) |
| "Analgesia, Fentanyl, Lidocaine spray, Pain, Rib fracture, Tramadol." | 9.69 | Comparison of the Analgesic Efficacy of Lidocaine Spray versus Tramadol and Fentanyl for Pain Control in Rib Fractures. ( Donmez, S; Erdem, AB; Sener, A, 2023) |
| "Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen." | 9.69 | Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023) |
| "To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1." | 9.51 | Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022) |
| "We tested the following hypothesis: The addition of intranasal fentanyl to the standard practice of local infiltration with lidocaine would provide better pain control than lidocaine alone for adult ED patients undergoing I&D." | 9.51 | A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess. ( Baer, J; Feliciano, C; Friedman, BW; Gupta, C; Latev, A; Sharpe, S, 2022) |
| "This study investigates the effects of COMTval158met gene polymorphism on maternal anxiety and pain during delivery and on the analgesic and anxiety efficacy of dexmedetomidine during delivery." | 9.51 | Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes. ( Feng, YJ; Han, J; Pu, CX; Tang, LJ; Zhang, Y, 2022) |
| "Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake." | 9.51 | Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022) |
| "To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)." | 9.41 | 'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021) |
| "This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department." | 9.41 | Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021) |
| "We sought to evaluate the efficacy of using a quick response (QR) code within video education to guide proper use of fentanyl transdermal patches and control pain, depression, and anxiety levels in cancer patients." | 9.34 | Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. ( Chen, J; Hu, X; Mao, X; Rao, Y; Xuan, Z; Yang, S; Ye, Z; Zhang, Y, 2020) |
| "To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries." | 9.30 | Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 9.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| "The neurodevelopmental impact of fentanyl given to preterm newborns for pain control is still unknown." | 9.24 | Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation. ( Ancora, G; Faldella, G; Ferrari, F; Garetti, E; Lago, P; Merazzi, D; Pierantoni, L; Pirelli, A, 2017) |
| "To compare pain incidence and changes in pain scores with fentanyl versus placebo as pre-emptive treatment during turning and 30 min post-turning in mechanically ventilated critically ill patients." | 9.22 | Fentanyl as pre-emptive treatment of pain associated with turning mechanically ventilated patients: a randomized controlled feasibility study. ( Baños, JE; Castillo, A; Gich, I; Juanes-Borrego, E; Mancebo, J; Navarro, M; Nicolás-Arfelis, JM; Puntillo, K; Robleda, G; Roche-Campo, F; Rodríguez-Arias, A; Sendra, MÀ; Urrutia, G, 2016) |
| "To evaluate the efficacy of oral transmucosal fentanyl citrate (OTFC) in the treatment of dyspnea on exertion in patients with advanced cancer." | 9.20 | A randomized crossover clinical trial to evaluate the efficacy of oral transmucosal fentanyl citrate in the treatment of dyspnea on exertion in patients with advanced cancer. ( Bruera, E; Correas, MÁ; Moralo, MJ; Pinna, MÁ; Vargas, RM, 2015) |
| "To compare the effectiveness and safety of fentanyl with placebo as pre-emptive treatment for pain associated with turning in patients in intensive care units." | 9.20 | A randomized controlled trial of fentanyl in the pre-emptive treatment of pain associated with turning in patients under mechanical ventilation: research protocol. ( Baños, JE; Castillo, A; Gich, I; Juanes-Borrejo, E; Mancebo, J; Navarro, M; Robleda, G; Roche-Campo, F; Rodríguez-Arias, A; Sendra, MÀ; Urrútia, G, 2015) |
| "Transdermal fentanyl is an effective, convenient, and well-tolerated treatment for mucositis pain caused by chemoradiotherapy, which can improve ESCC patients' quality of life." | 9.20 | Efficacy and safety of transdermal fentanyl for the treatment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma. ( Xing, SZ; Zhang, Y, 2015) |
| "Managing cancer pain often requires opioid medications, such as fentanyl, which is frequently initiated parenterally, and then converted to transdermal form." | 9.19 | Efficacy and safety of a six-hour continuous overlap method for converting intravenous to transdermal fentanyl in cancer pain. ( Bloise, R; Davis, MP; Samala, RV, 2014) |
| "To evaluate the pain on injection of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy." | 9.19 | Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy. ( Bao, Y; Shi, D; Zhang, L, 2014) |
| "Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl." | 9.19 | [Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014) |
| "Sublingual fentanyl proved inadequate in relieving pain during BMAB as no significant differences in the pain scores of the fentanyl and placebo patients were observed." | 9.17 | Pre-medication with sublingual fentanyl did not relieve pain associated with bone marrow aspiration and biopsy: a randomized feasibility trial. ( Ebeling, F; Kuivalainen, AM; Rosenberg, PH, 2013) |
| "In very preterm infants on mechanical ventilation, continuous fentanyl infusion plus open-label boluses of fentanyl does not reduce prolonged pain, but does reduce acute pain and increase side effects compared with open-label boluses of fentanyl alone." | 9.17 | Efficacy and safety of continuous infusion of fentanyl for pain control in preterm newborns on mechanical ventilation. ( Ancora, G; Faldella, G; Garetti, E; Lago, P; Mastrocola, M; Merazzi, D; Pierantoni, L; Pirelli, A, 2013) |
| "The study aimed to evaluate the effects of the pretreatment with lidocaine, fentanyl, and remifentanil using a venous occlusion technique in preventing pain caused by intravenous injection of rocuronium during induction of general anesthesia." | 9.17 | Comparison of three methods of preventing rocuronium induced pain on injection using venous occlusion technique: a randomized prospective double blind controlled study. ( Abu-Halaweh, NS; Abu-Halaweh, SA; Al-Hussami, MO; Al-Mustafa, M; Aloweidi, AK; Atyat, BS; Qudaisat, IY, 2013) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 9.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers." | 9.16 | A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Malver, LP; Mansikka, H; Oksche, A, 2012) |
| "This study compared the efficacy and safety of a 3-day-type transdermal fentanyl patch conversion by the rapid titration method to short-acting oral oxycodone for cancer pain." | 9.16 | [Three-day-type transdermal fentanyl patch conversion by rapid titration method with short-acting oral oxycodone for cancer pain]. ( Fujio, N; Ishikawa, N; Kameyama, M; Watanabe, H; Yamazaki, K, 2012) |
| "A number of transmucosal fentanyl formulations have been developed for the management of breakthrough cancer pain (BTCP)." | 9.16 | Efficacy and safety of fentanyl sublingual spray for the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study. ( Bull, J; Dillaha, L; Geach, J; Parikh, N; Rauck, R; Reynolds, L; Scherlis, M; Stearns, L, 2012) |
| "We prospectively investigated the reduced effects of adverse events caused by sustained-release oral morphine and controlled-release oxycodone after rotating to the fentanyl patch in patients with metastatic breast cancer." | 9.16 | [A pilot study of the reduced effects of adverse events caused by oral morphine and oxycodone after rotating to fentanyl patch in patients with metastatic breast cancer]. ( Fujii, S; Ikeda, M; Koike, Y; Kubo, S; Kurebayashi, J; Mizutou, A; Nakashima, K; Nomura, T; Oota, Y; Saitou, W; Seki, M; Shiiki, S; Shimo, T; Sonoo, H; Tanaka, K; Yamamoto, Y; Yamashita, T, 2012) |
| "3°C cold water), nerve growth factor-induced muscle soreness and intradermal capsaicin-induced hyperalgesia and allodynia." | 9.15 | Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models. ( Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN, 2011) |
| "We recently reported that fentanyl pectin nasal spray (FPNS) provides superior pain relief from breakthrough cancer pain (BTCP) compared with immediate-release morphine sulfate (IRMS), with significant effects by five minutes and clinically meaningful pain relief from 10 minutes postdose." | 9.15 | Consistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain. ( Brooks, D; Davies, A; Elsner, F; Espinosa, J; Fallon, M; Reale, C; Sitte, T, 2011) |
| "The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol." | 9.15 | Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011) |
| "To compare the effectiveness of nitrous oxide/oxygen (N(2)O/O(2)) and fentanyl in relieving pain among patients with an isolated long bone fracture or main joint dislocation of the limbs." | 9.15 | Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial. ( Amini, A; Derakhshanfar, H; Dolatabadi, AA; Hatamabadi, H; Kariman, H; Majidi, A; Shahrami, A; Sheibani, K; Yaseri, M, 2011) |
| "This study assessed the long-term safety and tolerability of fentanyl buccal tablet (FBT) in opioid-tolerant patients with cancer and breakthrough pain (BTP) who were either naive to FBT or had completed 1 of 2 previous double-blind, placebo-controlled FBT studies (rollover patients)." | 9.14 | Fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic cancer pain: A long-term, open-label safety study. ( Messina, J; Weinstein, SM; Xie, F, 2009) |
| " However, remifentanil continuous infusion proved to offer significantly more stable pain control compared with the currently used combination fentanyl-midazolam." | 9.14 | Analgesia during abdominal aortic aneurysm endovascular repair: remifentanil vs. fentanyl-midazolam--a randomized controlled trial. ( Barbieri, A; Bonfreschi, V; Coppi, G; D'Amico, R; Giuliani, E; Malagnino, FC; Navi, A; Silingardi, R, 2009) |
| "This trial investigated the efficacy and long-term tolerability of intranasal fentanyl spray (INFS) 50 to 200 microg in the treatment of breakthrough pain in opioid-tolerant patients with cancer." | 9.14 | Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: a phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatmen ( Colberg, T; Kaasa, S; Kaczmarek, Z; Kress, HG; Nolte, T; Orońska, A, 2009) |
| "The efficacy of intranasal fentanyl spray (INFS) was compared with that of oral transmucosal fentanyl citrate (OTFC) for the relief of cancer-related breakthrough pain (BTP) in an open-label, crossover trial." | 9.14 | A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial. ( Camba, MA; Colberg, T; Davies, A; Mercadante, S; Perkins, P; Poulain, P; Radbruch, L; Sitte, T, 2009) |
| "The aim of this study was to compare the efficacy of intravenous pretreatment with fentanyl 50 microg, fentanyl 100 microg, and lidocaine 40 mg, preceded by venous occlusion, for reducing pain on injection of propofol in adult Japanese surgical patients." | 9.14 | A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients. ( Fujii, Y; Itakura, M, 2009) |
| "Fentanyl buccal soluble film (FBSF) has been developed as a treatment of breakthrough pain in opioid-tolerant patients with cancer." | 9.14 | Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study. ( Finn, AL; Gever, LN; North, J; Rauck, R; Tagarro, I, 2010) |
| "In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients." | 9.14 | Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010) |
| "This study evaluated the efficacy and safety of transdermal fentanyl in the outpatient treatment of head and neck cancer patients with pain caused by radiotherapy." | 9.14 | Transdermal fentanyl for pain caused by radiotherapy in head and neck cancer patients treated in an outpatient setting: a multicenter trial in Taiwan. ( Chang, JT; Chen, YJ; Lee, MS; Lin, CY; Lin, JC; Wang, HM, 2010) |
| "To determine if intranasal (IN) fentanyl is effective at decreasing pain that children feel during catheterization of VCUG when compared with sterile water." | 9.14 | Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography. ( Chung, S; Goldman, RD; Lim, R, 2010) |
| "kg(-1) added to bupivacaine significantly improves the quality of intraoperative analgesia and prolongs postoperative analgesia in children undergoing inguinal hernia repair with spinal anesthesia." | 9.14 | Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair. ( Apiliogullari, S; Duman, A; Duman, I, 2010) |
| "The intent of our study was to compare the effects of dexmedetomidine versus midazolam on perioperative hemodynamics, sedation, pain, satisfaction and recovery scores during colonoscopy." | 9.14 | A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation. ( Budak, ET; Dagli, G; Dere, K; Filiz, AI; Ozkan, S; Sucullu, I; Yeyen, S, 2010) |
| "This randomized, double-blind, crossover study assessed the efficacy and tolerability of a new rapid onset nasal fentanyl formulation (Fentanyl Pectin Nasal Spray; FPNS) for breakthrough cancer pain (BTCP)." | 9.14 | A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain. ( Burton, AW; Gabrail, N; Portenoy, RK; Taylor, D, 2010) |
| "To evaluate the time of onset, overall efficacy, and safety of fentanyl buccal tablet (FBT) for noncancer-related breakthrough pain (BTP) in opioid-tolerant adults over 12 weeks." | 9.14 | A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain. ( Farrar, JT; Messina, J; Portenoy, RK; Xie, F, 2010) |
| "We examined the efficacy and safety of a new transdermal fentanyl citrate patch (HFT-290), which was applied once daily in patients with cancer pain who were receiving a stable dose of once-every-three-day application transdermal fentanyl patch [TDF (72 hr)]." | 9.14 | [A phase II clinical study of once-a-day fentanyl citrate patch in patients with cancer pain--switching from once-every-three-days fentanyl patch to once-a-day fentanyl citrate patch]. ( Hashizume, T; Iseki, M; Iwao, Y; Kitajima, T; Masuda, Y; Matoba, M; Miyazaki, T; Namiki, A; Ogawa, S; Uchida, E, 2010) |
| "The aim of this study was to evaluate the effect and tolerability of low doses of transdermal (TD) fentanyl patches in opioid-naive patients with cancer pain." | 9.14 | Low doses of transdermal fentanyl in opioid-naive patients with cancer pain. ( Adile, C; Aielli, F; Ferrera, P; Ficorella, C; Mercadante, S; Porzio, G, 2010) |
| "The objective was to evaluate the use of a single 2 μg/kg dose of intranasal fentanyl as analgesia for painful orthopedic injuries in children presenting to a pediatric emergency department (ED)." | 9.14 | Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain. ( Adelgais, K; Nelson, D; Saunders, M, 2010) |
| "Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0." | 9.13 | Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008) |
| "Fentanyl, a short-acting synthetic opioid, has a pharmacokinetic profile suited to fast relief of brief episodic pain." | 9.13 | Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. ( Christrup, L; Foster, D; Popper, L; Upton, R, 2008) |
| "We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy." | 9.13 | Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008) |
| "We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro." | 9.13 | Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine. ( Ahmad, N; Balan, S; Zanariah, Y, 2008) |
| "To compare the efficacy of fentanyl and remifentanil as prodrugs in the prevention of rocuronium injection pain by using a control group." | 9.13 | Comparison of the effectiveness of pretreatment by fentanyl and remifentanil on rocuronium induced injection pain. ( Bayindir, S; Ellidokuz, H; Gunerli, A; Iyilikci, L; Sari, M, 2008) |
| "A novel transdermal matrix patch delivery system for fentanyl has been developed to deliver improved management of cancer pain compared with that obtained using current fentanyl reservoir patches." | 9.13 | Efficacy, safety and pharmacokinetic study of a novel fentanyl-containing matrix transdermal patch system in Japanese patients with cancer pain. ( Hanaoka, K; Hosokawa, T; Ishida, T; Kitajima, T; Mashimo, S; Miyazaki, T; Namiki, A; Nogami, S; Ogawa, S, 2008) |
| "The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial." | 9.12 | Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021) |
| " The patient is a 50-year-old female with widely metastatic breast cancer who developed opioid toxicity when maintenance transdermal fentanyl patch therapy (100 μg patch applied every 72 h) was rotated to subcutaneous hydromorphone infusion to improve pain control." | 9.12 | Opioid rotation from transdermal fentanyl to continuous subcutaneous hydromorphone in a cachectic patient: A case report and review of the literature. ( Chua, D; Jackson, LD; Selby, D; Wortzman, R, 2021) |
| "This trial demonstrated that the lower 12 microg/h dose of fentanyl TTS provided a therapeutic benefit in non-malignant chronic pain, with a similar AE rate but a lower drop-out rate than that seen in trials at higher doses." | 9.12 | A Phase III study to assess the clinical utility of low-dose fentanyl transdermal system in patients with chronic nonmalignant pain. ( Otis, J; Rothman, M, 2006) |
| "We compare the efficacy of intranasal fentanyl versus intravenous morphine in a pediatric population presenting to an emergency department (ED) with acute long-bone fractures." | 9.12 | A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. ( Borland, M; Jacobs, I; King, B; O'Brien, D, 2007) |
| "Fifty-six adults with chronic noncancer pain using oral transmucosal fentanyl citrate (OTFC, ACTIQ)." | 9.12 | Impact of breakthrough pain on quality of life in patients with chronic, noncancer pain: patient perceptions and effect of treatment with oral transmucosal fentanyl citrate (OTFC, ACTIQ). ( Chun, SY; Fortner, B; Reinking, J; Shoemaker, S; Stegman, M; Taylor, DR; Webster, LR, 2007) |
| "Patients experiencing pain during daily dressing changes were given entonox plus either placebo or oral transmucosal fentanyl citrate (OTFC) for two consecutive dressing changes in a randomised double-blind placebo-controlled crossover trial." | 9.12 | Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial. ( Barker, L; Larsen, D; MacIntyre, PA; Margetts, L, 2007) |
| "The use of OTFC can provide improved pain control when compared with IV morphine." | 9.12 | A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007) |
| "To compare the pain relief achieved with nebulized fentanyl citrate with intravenous (i." | 9.12 | Randomized clinical trial of nebulized fentanyl citrate versus i.v. fentanyl citrate in children presenting to the emergency department with acute pain. ( Biros, MH; Herold, M; Hubbard, D; Kletti, C; Miner, JR, 2007) |
| " In this randomized open-label study the influence of tramadol on dose adjustment of transdermal fentanyl in advanced cancer pain control was prospectively evaluated." | 9.12 | Improved cancer pain treatment using combined fentanyl-TTS and tramadol. ( Aloisio, L; Bajocco, C; Ciccozzi, A; Coaccioli, S; Colangeli, A; Marinangeli, F; Paladini, A; Varrassi, G, 2007) |
| "Various strategies have been studied to reduce the discomfort of rocuronium pain." | 9.12 | Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine. ( Bithal, PK; Chauhan, H; Dash, HH; Prabhakar, H; Rath, GP; Singh, M, 2007) |
| "To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain." | 9.11 | Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004) |
| "To determine the safety and efficacy of transdermal fentanyl for pain relief in cancer patients and to compare the effects on patients according to whether they had previously received strong opioids, weak opioids or non-opioid analgesia." | 9.11 | Use of transdermal fentanyl without prior opioid stabilization in patients with cancer pain. ( Bryuzgin, V; Kourteva, G; Tawfik, MO, 2004) |
| "The aim of this observational study was to examine pain management outcomes and quality of life (QoL) measures in cancer patients with intolerable or chronic severe pain transferring from World Health Organization's step I, II, and III analgesics to the transdermal therapeutic fentanyl system (TTS-F)." | 9.11 | Pain management of cancer patients with transdermal fentanyl: a study of 1828 step I, II, & III transfers. ( Georgaki, S; Katsouda, E; Kouloulias, V; Kouvaris, J; Mystakidou, K; Parpa, E; Tsilika, E; Vlahos, L, 2004) |
| "This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients." | 9.11 | A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004) |
| "Sufentanil, a potent mu-opioid agonist, historically has not been been given systemically to treat chronic pain." | 9.11 | Relative analgesic potency of fentanyl and sufentanil during intermediate-term infusions in patients after long-term opioid treatment for chronic pain. ( Charapata, S; DuPen, S; Fisher, DM; Heinze, E; Katz, N; Portenoy, R; Rauck, R; Reynolds, L; Wallace, M; Webster, L, 2004) |
| "Fentanyl is commonly used for spinal analgesia during labour but it is associated with a high incidence of pruritus." | 9.11 | Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron. ( Evans, SF; Paech, MJ; Wells, J, 2004) |
| "We treated 50 patients with chronic nonmalignant pain using transdermal fentanyl (TDF) 25 microg/hr and concurrently measured pain using a visual analog scale (VAS) and serum cortisol concentration." | 9.11 | The effect of transdermal fentanyl treatment on serum cortisol concentrations in patients with non-cancer pain. ( Altan, A; Ozyuvaci, E; Yanmaz Alnigenis, N, 2004) |
| "We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery." | 9.11 | Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004) |
| "This study evaluated transdermal fentanyl (TDF) for the treatment of pain from rheumatoid arthritis (RA) which was not adequately controlled by nonopioid analgesics and/or weak opioids." | 9.11 | Transdermal fentanyl for the treatment of pain caused by rheumatoid arthritis. ( Bjorneboe, O; Herrero-Beaumont, G; Richarz, U, 2004) |
| " Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 9.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
| "To evaluate the effectiveness and safety of transdermal fentanyl (TDF) for the treatment of pain associated with rheumatoid arthritis (RA) or osteoarthritis of the knee or hip (OA), which was not adequately controlled by non-opioid analgesics and/or weak opioids." | 9.11 | Benefits of transdermal fentanyl in patients with rheumatoid arthritis or with osteoarthritis of the knee or hip: an open-label study to assess pain control. ( Bjorneboe, O; Herrero-Beaumont, G; Le Loet, X; Pavelka, K; Richarz, U, 2004) |
| "This study was designed to evaluate the utility of transdermal fentanyl (TDF, Durogesic) for the treatment of pain due to osteoarthritis (OA) of the knee or hip, which was not adequately controlled by non-opioid analgesics or weak opioids." | 9.11 | Transdermal fentanyl for the treatment of pain caused by osteoarthritis of the knee or hip: an open, multicentre study. ( Le Loët, X; Pavelka, K; Richarz, U, 2005) |
| "We evaluated the effects of gabapentin and carbamazepine for pain relief in 36 Guillain-Barré syndrome patients." | 9.11 | The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unit. ( Kumar, A; Navkar, DV; Pandey, CK; Raza, M; Singh, UK; Tripathi, M, 2005) |
| "Chronic pain can be effectively treated with fentanyl-TTS, which has a very favorable side effect profile." | 9.11 | [Individual aspects of the quality of life of patients with chronic pain. Observational study of treatment with fentanyl-TTS]. ( Waap, I; Zimmermann, M, 2005) |
| "When compared with rocuronium alone, only the addition of saline failed to significantly reduce the pain reported by patients." | 9.10 | Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium. ( Chiarella, AB; Clanachan, AS; Huston, CM; Jolly, DT, 2003) |
| "The findings suggest that a single lumbar epidural dose of fentanyl should be injected at the spinal interspace corresponding to the dermatomal site of pain." | 9.10 | Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain. ( Arendt-Nielsen, L; Curatolo, M; Eichenberger, U; Giani, C; Graven-Nielsen, T; Petersen-Felix, S, 2003) |
| "To determine the effects of systemic fentanyl analgesia in preventing the pain related to the administration of retrobulbar anesthesia and cataract surgery." | 9.10 | Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification. ( Ermis, SS; Inan, UU; Oztürk, F; Sivaci, RG, 2003) |
| "To measure the plasma fentanyl concentrations achieved over time with transdermal fentanyl patches in awake cats and cats undergoing anesthesia and ovariohysterectomy." | 9.10 | Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration. ( Allen, SW; Egger, CM; Glerum, LE; Haag, M, 2003) |
| "This randomised, multicentre, direct open comparative trial evaluated the efficacy, treatment convenience, tolerability and safety aspects of transdermal therapeutic system (TTS)-fentanyl and sustained-release oral morphine (SRM) in both opioid-naïve patients with moderate-to-severe cancer-related pain and in patients who had already been using opioids for mild-to-moderate pain." | 9.10 | Comparison of TTS-fentanyl with sustained-release oral morphine in the treatment of patients not using opioids for mild-to-moderate pain. ( Schipper, RM; Smit, JM; van Seventer, R; Wicks, MA; Zuurmond, WW, 2003) |
| "Transdermal therapeutic system-fentanyl (TTS-F) has been extensively studied in cancer pain management." | 9.10 | Long-term management of noncancer pain with transdermal therapeutic system-fentanyl. ( Georgaki, S; Mavromati, A; Mystakidou, K; Parpa, E; Smyrniotis, V; Tsilika, E; Vlahos, L, 2003) |
| "Analgesic treatment with TTS fentanyl used as a single opioid is effective and safe for cancer pain relief, given that is cautiously applied, in patients requiring strong opioid analgesics even if they were naive to strong or mild opioids." | 9.10 | Use of TTS fentanyl as a single opioid for cancer pain relief: a safety and efficacy clinical trial in patients naive to mild or strong opioids. ( Befon, S; Dardoufas, K; Georgaki, S; Mystakidou, K; Tsilika, E; Vlahos, L, 2002) |
| "The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies." | 9.10 | Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002) |
| " In the postanesthesia care unit (PACU), fentanyl 25 microg was administered for a verbal analog scale (VAS) pain score >or=3." | 9.10 | Preoperative administration of controlled-release oxycodone for the management of pain after ambulatory laparoscopic tubal ligation surgery. ( Joshi, W; Maciolek, H; Reuben, SS; Steinberg, RB, 2002) |
| "We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients." | 9.10 | The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "Constipation and the use of laxatives were investigated in patients with chronic cancer pain treated with oral morphine and transdermal fentanyl in an open sequential trial." | 9.09 | Constipation and the use of laxatives: a comparison between transdermal fentanyl and oral morphine. ( Grond, S; Kasper, M; Kulbe, C; Lehmann, KA; Loick, G; Radbruch, L; Sabatowski, R, 2000) |
| "Transdermal Fentanyl (TF, Durogesic) is a strong opioid analgesic which is used in the treatment of cancer pain." | 9.09 | [Research from the Palliative Care Department in Poznań on treatment of neoplasm pain with Durogesic (transdermal fentanyl)]. ( Gorzelińska, L; Kozikowska, J; Leppert, W; Luczak, J, 2000) |
| "To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain control, and their quality of life after treatment." | 9.09 | Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. ( Allan, L; Bolt, M; de Waroux, BL; Donald, R; Hays, H; Jensen, NH; Kalso, E, 2001) |
| "Our aim was to find out whether intravenous fentanyl was effective in reducing the pain of first-trimester abortion." | 9.09 | A randomized controlled trial of fentanyl for abortion pain. ( Rawling, MJ; Wiebe, ER, 2001) |
| "This open-label study evaluated the long-term safety and tolerability of oral transmucosal fentanyl citrate (OTFC) in ambulatory cancer patients with breakthrough pain undergoing cancer care at 32 university- or community-based practices." | 9.09 | Long-term safety of oral transmucosal fentanyl citrate for breakthrough cancer pain. ( Berris, R; Busch, MA; Coluzzi, P; Hart, L; Loseth, DB; Lyss, A; Nordbrook, E; Payne, R; Portenoy, RK; Rauck, R; Simmonds, M, 2001) |
| "The effects of sublingual fentanyl citrate (SLFC) were assessed in 11 hospice inpatients with cancer-related breakthrough pain." | 9.09 | Sublingual fentanyl citrate for cancer-related breakthrough pain: a pilot study. ( Zeppetella, G, 2001) |
| "To investigate the efficacy and safety of oral transmucosal fentanyl (OTFC) in providing analgesia and sedation for painful diagnostic procedures in children." | 9.08 | The use of oral transmucosal fentanyl citrate for painful procedures in children. ( Bernstein, B; Conard, PL; Rosenblum, M; Schechter, NL; Weisman, SJ, 1995) |
| "Direct conversion from oral morphine to transdermal fentanyl with a ratio of oral morphine/transdermal fentanyl (100:1 mg) daily was examined in patients with cancer pain." | 9.08 | Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain. ( Donner, B; Strumpf, M; Tryba, M; Zenz, M, 1996) |
| "We performed an open-label pilot study to define analgesic efficacy, acceptability, and toxicity of transdermal fentanyl in an ambulatory population of patients with cancer pain." | 9.08 | Transdermal fentanyl in the management of cancer pain in ambulatory patients: an open-label pilot study. ( Fidler, P; Hammack, JE; Loprinzi, CL; Mailliard, JA; Michalak, JC; Miser, AW; O'Fallon, JR; Reuter, NF; Rospond, RM; Wilwerding, MB, 1996) |
| "To compare the local efficacy of lidocaine and fentanyl in reducing propofol injection pain (PIP), we conducted a prospective randomized double-blind study in 75 ASA I and II adult patients." | 9.08 | Reduction of propofol pain--fentanyl vs lidocaine. ( Alyafi, WA; Rangasami, J, 1996) |
| "We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain." | 9.08 | Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997) |
| "A prospective phase II study was conducted to define the analgesic efficacy, acceptability and toxicity of the transdermal therapeutic system (TTS) of fentanyl in Chinese patients with severe cancer-related pain." | 9.08 | Transdermal fentanyl for severe cancer-related pain. ( Chan, AT; Johnson, PJ; Lam, KK; Leung, TW; Nip, SY; Yeo, W, 1997) |
| "To compare pain-related treatment satisfaction, patient-perceived side effects, functioning, and well-being in patients with advanced cancer who were receiving either transdermal fentanyl (Duragesic, Janssen Pharmaceuticals, Titusville, NJ) or sustained-release oral forms of morphine (MS Contin, Perdue Frederick Co, Norwalk, CT, or Oramorph SR, Roxanne Laboratories, Columbus, OH)." | 9.08 | Quality of life and cancer pain: satisfaction and side effects with transdermal fentanyl versus oral morphine. ( Mahmoud, R; Mathias, SD; Pasta, DJ; Payne, R; Wanke, LA; Williams, R, 1998) |
| ") retention of fentanyl and lidocaine in reducing the pain on i." | 9.08 | Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain. ( Chang, DP; Chung, YT; Hong, MH; Huang, S; Lin, SS; Pang, WW, 1997) |
| "Patients who were 18 years of age or older, receiving the equivalent of at least 60 mg oral morphine or at least 50 microg transdermal fentanyl per day for chronic cancer-related pain, and experiencing at least one episode of breakthrough pain per day were studied." | 9.08 | Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients. ( Busch, M; Cleary, J; Farrar, JT; Nordbrock, E; Rauck, R, 1998) |
| "Pain on injection is one of the well-known side effects of propofol." | 9.08 | [Pain-free injection of propofol]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Kumagai, A; Namiki, A; Seki, S; Tsuchida, H, 1998) |
| "We compared the effect of fentanyl and lidocaine on pain during injection of propofol." | 9.08 | [Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine]. ( Aketa, K; Ichimiya, T; Kobayashi, Y; Naganuma, R; Namiki, A; Seki, S, 1998) |
| "This was a multicenter, randomized, double-blind, dose-titration study in 62 adult cancer patients using transdermal fentanyl for persistent pain." | 9.08 | Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain. ( Busch, MA; Christie, JM; Coluzzi, P; Nordbrock, E; Patt, R; Portenoy, RK; Simmonds, M, 1998) |
| "All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)." | 9.07 | Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 9.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "The effect of fentanyl, administered immediately before propofol, when pain is experienced at the site of propofol injection was studied in 28 children undergoing elective surgery." | 9.07 | [Fentanyl prevents the pain at the site of propofol injection]. ( Chessa, D; Cossu, F; Serra, G, 1992) |
| "In this study, 6 patients with pain from advanced cancer were enrolled in a multicenter, open-label seeding trial of transdermal fentanyl." | 9.07 | Transdermal fentanyl: seeding trial in patients with chronic cancer pain. ( Kedziera, P; Levy, MH; Rosen, SM, 1992) |
| "Patients were entered into an open label study to evaluate the efficacy of transdermal fentanyl as an analgesic for chronic cancer pain." | 9.07 | Transdermal fentanyl for chronic cancer pain: detailed case reports and the influence of confounding factors. ( Hogan, LA; Patt, RB, 1992) |
| "In this study, 11 cancer patients who experienced severe pain were treated with transdermal fentanyl." | 9.07 | Transdermal fentanyl use in hospice home-care patients with chronic cancer pain. ( Herbst, LH; Strause, LG, 1992) |
| "A multicenter study was conducted to determine the patient and physician acceptability of transdermal fentanyl in the management of cancer-related pain." | 9.07 | Management of cancer pain with transdermal fentanyl: phase IV trial, University of Iowa. ( Barcellos, WA; Maves, TJ, 1992) |
| "To evaluate the efficacy of opiate administration regimens, 32 patients with multiple rib fractures were prospectively randomized to receive either continuous epidural (ED) or continuous intravenous (IV) infusions of fentanyl." | 9.07 | Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures. ( Davis, JW; Hoyt, DB; Karagianes, TG; Mackersie, RC, 1991) |
| "To systematically compare the efficacy and safety of sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia (CSEA), a systematic review and meta-analysis of randomized controlled trials targeting parturients requesting labor analgesia was conducted." | 9.05 | Sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia: a systematic review and meta-analysis of randomized controlled trials. ( Diao, Y; Geng, S; Huang, Z; Liu, S; Liu, Y; Shen, L; Su, X; Sun, J; Zhi, M, 2020) |
| "To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 9.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
| "Forty subjects rated the magnitude of painful electrical stimulation of tooth pulp before and after the intravenous administration of either fentanyl, a short-acting narcotic, or a saline placebo." | 9.04 | Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. ( Dubner, R; Gracely, RH; McGrath, PA, 1979) |
| "The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration." | 8.93 | Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016) |
| " This rapid review, commissioned by the National Institute for Health Research, used standard Cochrane methodology to examine adverse effects of morphine, fentanyl, oxycodone, and codeine in cancer pain studies as a close approximation to possible effects in the dying patient." | 8.90 | Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2014) |
| "To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain." | 8.89 | Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013) |
| "The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine." | 8.88 | Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012) |
| "To evaluate the long-term dosing, safety, and tolerability of fentanyl buccal tablet (FBT) in a large cohort of opioid-tolerant patients with chronic noncancer pain and breakthrough pain (BTP)." | 8.87 | Long-term dosing, safety, and tolerability of fentanyl buccal tablet in the management of noncancer-related breakthrough pain in opioid-tolerant patients. ( Janka, L; Nalamachu, SR; Narayana, A, 2011) |
| "Oral transmucosal fentanyl citrate (OTFC) and fentanyl buccal tablets are the first medications developed specifically for the treatment of breakthrough pain in opioid-tolerant patients." | 8.87 | Fentanyl nasal spray for the treatment of cancer pain. ( Gouliamos, A; Mystakidou, K; Panagiotou, I, 2011) |
| "A short cut review was carried out to establish whether intranasal fentanyl is better than parenteral morphine for managing acute severe pain in children." | 8.87 | Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 4: is intranasal fentanyl better than parenteral morphine for managing acute severe pain in children? ( Kusre, SR, 2011) |
| "To compare the efficacy of intranasal fentanyl spray (INFS), oral transmucosal fentanyl citrate (OTFC), fentanyl buccal tablet (FBT) and oral morphine (OM) for the treatment of breakthrough cancer pain (BTCP)." | 8.86 | Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer. ( Jansen, J; Lenre, M; Nolte, T; Stam, W; Vissers, D, 2010) |
| "Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects." | 8.86 | Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis. ( Bi, ZF; Chen, DL; Jiang, ZM; Ma, W; Xie, DR; Yang, Q; Zhang, YD, 2010) |
| "Review key aspects of breakthrough pain management with fentanyl buccal tablet, with a focus on minimizing risk to optimize therapeutic outcomes." | 8.86 | Treatment of breakthrough pain with fentanyl buccal tablet in opioid-tolerant patients with chronic pain: appropriate patient selection and management. ( Fine, PG; Narayana, A; Passik, SD, 2010) |
| "Transdermal fentanyl patches first became available in the early 1990s and provided an innovative treatment for the management of cancer pain." | 8.85 | The role of transdermal fentanyl patches in the effective management of cancer pain. ( Gibbs, M, 2009) |
| "The safety of transdermal fentanyl (TF) in comparison with slow-release oral morphine (SROM) in moderate-severe pain was assessed." | 8.85 | Transdermal fentanyl as a front-line approach to moderate-severe pain: a meta-analysis of randomized clinical trials. ( Maltoni, M; Santelmo, C; Sartori, S; Scarpi, E; Tamburini, E; Tassinari, D; Tombesi, P, 2009) |
| "In the present study, we demonstrated that repeated treatment with fentanyl, but not morphine or oxycodone, causes a rapid desensitization to its ability to block the hyperalgesia associated with the attenuation of mu-opioid receptor resensitization in mice in a chronic pain-like state." | 8.84 | [Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state]. ( Hashimoto, S; Kuzumaki, N; Nakamura, A; Narita, M; Ozeki, A; Satoshi, I; Suzuki, T; Uezono, Y, 2008) |
| "To assess the adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison with slow release oral morphine." | 8.84 | Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature. ( Maltoni, M; Raffaeli, W; Sartori, S; Scarpi, E; Tamburini, E; Tassinari, D; Tombesi, P, 2008) |
| "Transdermal buprenorphine has been assessed as a therapy for chronic cancer and non-cancer pain in both clinical and postmarketing surveillance studies." | 8.83 | Transdermal buprenorphine in cancer pain and palliative care. ( Sittl, R, 2006) |
| "The fentanyl buccal tablet (FBT) is a new formulation of fentanyl that uses an effervescent drug delivery system to enhance penetration across the buccal mucosa for the treatment of breakthrough pain in opioid-tolerant patients with cancer." | 8.83 | Fentanyl buccal tablet: in breakthrough pain in opioid-tolerant patients with cancer. ( Blick, SK; Wagstaff, AJ, 2006) |
| "Transdermal fentanyl is effective and well tolerated for the treatment of chronic pain caused by malignancy and non-malignant conditions when administered according to the manufacturer's recommendations." | 8.82 | Benefit-risk assessment of transdermal fentanyl for the treatment of chronic pain. ( Kornick, CA; Moryl, N; Obbens, EA; Payne, R; Santiago-Palma, J, 2003) |
| "To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and randomised controlled (with SRM as comparator) studies of TDF." | 8.82 | Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain. ( Ahmedzai, SH; Allan, LG; Camacho, F; Clark, AJ; Horbay, GL; Richarz, U; Simpson, K, 2004) |
| "Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain." | 8.81 | Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001) |
| "Transdermal fentanyl appears to be a safe and practical alternative to short-acting analgesics in the treatment of cancer pain." | 8.78 | Transdermal fentanyl in cancer pain. ( Mosser, KH, 1992) |
| "The physicochemical properties, pharmacology, pharmacokinetics, serum concentrations and clinical effects, adverse effects and contraindications, and dosage of transdermally administered fentanyl are described, and clinical studies evaluating the use of a transdermal fentanyl system in the treatment of postoperative pain and chronic cancer-associated pain are reviewed." | 8.78 | Transdermally administered fentanyl for pain management. ( Calis, KA; Corso, DM; Kohler, DR, 1992) |
| "Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related pain." | 8.31 | An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management. ( Bahrami, F; De Nys, K; Defraeye, T; Rossi, RM, 2023) |
| "Fentanyl is a potent analgesic with a rapid onset and short half-life that make it a useful treatment for pain and a lethal drug of abuse." | 8.31 | Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation. ( Hilgendorf, TN; Kandasamy, R; Morgan, MM, 2023) |
| "The aim of this study was to assess the safety of fentanyl analgosedation during therapeutic hypothermia, by evaluating severe adverse effects and possible correlation with the neurodevelopmental outcome." | 8.12 | Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia. ( Bedetti, L; Berardi, A; Della Casa, E; Ferrari, F; Garetti, E; Guidotti, I; Iughetti, L; Lago, P; Lucaccioni, L; Lugli, L; Pugliese, M; Roversi, MF; Spada, C, 2022) |
| "This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain." | 8.12 | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology. ( Bi, J; Wan, H; Wang, S; Zhao, J; Zhao, W; Zhou, S, 2022) |
| "It is recommended not to use transdermal fentanyl (Fe) patches (TFP) in cancer cachexia but TFP may be the only available option for pain." | 8.12 | Transdermal fentanyl to parenteral morphine route switch and drug rotation in refractory cancer cachexia. ( Alabdullateef, SH; Almashiakhi, M; Alsirafy, SA; Elyamany, AM; Hassan, AD, 2022) |
| "Nebulized fentanyl is well established for analgesia but its use for dyspnea requires further investigation." | 7.96 | Nebulized Fentanyl for Dyspnea: A Retrospective Chart Review. ( Cain, J; Coyne, PJ; Dulin, JD; Higgins, EA; Miller, MM; Overstreet, AN; Vaughan, L; Young, AM, 2020) |
| "Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)." | 7.96 | Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020) |
| "Fentanyl has been associated with many drug overdose deaths; its presence in many street drugs has been postulated to be increasing." | 7.96 | Correlation of Fentanyl Positive Drug Screens with Other Medications in Patients from Pain, Rehabilitation and Behavioral Programs. ( Greg Ackerman, RT; Krock, K; Nickley, J; Pesce, A; Tran, K, 2020) |
| "To test the effectiveness of a premedication protocol using intravenous bolus of 100 μg fentanyl to reduce pain associated with femoral artery closure device placement for neuro-endovascular procedures." | 7.91 | Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement. ( Naseem, N; Qureshi, AI; Saleem, MA; Wallery, SS, 2019) |
| " Even after multiple testing with Bonferroni adjustments, an increase in the analgesic effect of fentanyl in the cold pressor-induced pain test was significantly associated with a greater number of the A allele of the rs7583431 SNP (linear regression, P = ." | 7.88 | Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test. ( Aoki, Y; Fukuda, KI; Hasegawa, J; Hayashida, M; Ichinohe, T; Ikeda, K; Kasai, S; Koukita, Y; Nishizawa, D; Takahashi, K; Yoshida, K, 2018) |
| "Our aim was to evaluate a nurse-initiated pain-management protocol in adult patients with traumatic injuries in the short and in the long term, utilizing fentanyl for severe pain." | 7.85 | Emergency Department Pain Management in Adult Patients With Traumatic Injuries Before and After Implementation of a Nurse-Initiated Pain Treatment Protocol Utilizing Fentanyl for Severe Pain. ( Goslings, JC; Hollmann, MW; Lirk, P; Ridderikhof, ML; Schep, NW; Schyns, FJ, 2017) |
| "To assess the effectiveness of nebulized fentanyl used for analgesia in renal colic." | 7.85 | A retrospective analysis of nebulized versus intravenous fentanyl for renal colic. ( Aygun, A; Bekar, O; Cicek, M; Erdem, E; Imamoglu, M; Karaca, Y; Sahin, A; Tatli, O; Turedi, S; Turkmen, S, 2017) |
| "To explore analgesic effects of fentanyl and butorphanol on incisional pain in rats and to investigate the pharmacological mechanism of combination." | 7.83 | Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain. ( Chen, Q; Li, P; Liu, GL; Shang, Y; Xu, Y, 2016) |
| "Little is known about the efficacy of low-dose transdermal fentanyl (TDF) patches in opioid-naïve patients with moderate-to-severe cancer pain." | 7.81 | The efficacy of low-dose transdermal fentanyl in opioid-naïve cancer patients with moderate-to-severe pain. ( Hwang, IG; Kang, JH; Kim, JH; Kim, WS; Lee, HR; Lee, HY; Lee, KE; Oh, SY; Park, K; Park, SH; Park, YS; Song, SY, 2015) |
| "This study aims to determine whether a pathway designed to facilitate the use of intranasal (IN) fentanyl for long-bone fractures will expedite the delivery of pain medication, decrease the total length of emergency department (ED) stay, and provide faster analgesia compared with intravenous (IV) morphine." | 7.81 | Expedited Delivery of Pain Medication for Long-Bone Fractures Using an Intranasal Fentanyl Clinical Pathway. ( Erikson Ramirez, D; Frazier, SB; Perkins, AM; Schacherer, NM, 2015) |
| "Intranasal fentanyl seems to be efficient for analgesia in adult patients with renal colic." | 7.81 | Does intranasal fentanyl provide efficient analgesia for renal colic in adults? ( Bakkali, H; Belkouch, A; Belyamani, L; Chouaib, N; Elbouti, A; Rafai, M; Sirbou, R; Zidouh, S, 2015) |
| "Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment." | 7.81 | Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl. ( Barratt, DT; Dale, O; Kaasa, S; Klepstad, P; Somogyi, AA, 2015) |
| " infusion of fentanyl in patients with hepatocellular carcinoma (HCC) treated by RFA." | 7.80 | Pain control in patients with hepatocellular carcinoma treated by percutaneous radiofrequency ablation: comparison of the efficacy of one-shot and continuous intravenous fentanyl delivery. ( Ikeda, O; Inoue, S; Kawanaka, K; Nakasone, Y; Tamura, Y; Yamashita, Y; Yokoyama, K, 2014) |
| "It is unknown whether nutritional status influences pain intensity in cancer patients receiving a transdermal fentanyl patch (FP)." | 7.80 | A retrospective study on the influence of nutritional status on pain management in cancer patients using the transdermal fentanyl patch. ( Chiba, T; Kimura, Y; Kudo, K; Tairabune, T; Takahashi, H; Takahashi, K; Wakabayashi, G, 2014) |
| "This study evaluated the efficacy, safety, and quality of life (QoL) measure of transdermal fentanyl (TDF) for moderate-to-severe pain due to oral mucositis caused by chemoradiotherapy in patients with advanced nasopharyngeal carcinoma (NPC)." | 7.80 | Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life. ( Feng, HX; Guo, SP; He, ZY; Li, FY; Sun, JY; Wu, SG; Wu, YJ; Zhou, J, 2014) |
| "Cold pain sensitivity and analgesic effects of fentanyl were related to the SNP and haplotypes of the P2RX7 gene." | 7.80 | Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. ( Fukuda, K; Hasegawa, J; Hayashida, M; Ide, S; Ikeda, K; Kasai, S; Minami, M; Nishizawa, D, 2014) |
| "Morphine, oxycodone, and fentanyl are commonly used to control cancer pain." | 7.80 | Influence of serum albumin levels during opioid rotation from morphine or oxycodone to fentanyl for cancer pain. ( Arakawa, Y; Fukuura, K; Futamura, A; Hayashi, T; Higashiguchi, T; Ikehata, S; Kuki, R; Makihara, T; Matsuzaki, H; Mori, N; Takahashi, H; Yamadaa, S; Yasuda, K, 2014) |
| "Palliative care physicians are accustomed to using transdermal fentanyl patch for cancer pain control but not so familiar with its intravenous administration." | 7.80 | Use of intravenous fentanyl against morphine tolerance in breakthrough cancer pain: a case series and literature review. ( Bruera, E; Hwang, IC; Park, SM, 2014) |
| "Utility functions based on fentanyl's experimental effects on respiration and pain relief were successfully constructed." | 7.79 | Fentanyl utility function: a risk-benefit composite of pain relief and breathing responses. ( Aarts, L; Boom, M; Dahan, A; Fussen, R; Groeneveld, GJ; Hay, J; Neukirchen, M; Olofsen, E; Sarton, E, 2013) |
| "Fentanyl pectin nasal spray is a novel intranasal formulation for the management of breakthrough cancer pain in patients taking and tolerant to opioids for persistent cancer pain." | 7.79 | Fentanyl pectin nasal spray: a novel intranasal delivery method for the treatment of breakthrough cancer pain. ( Bulloch, MN; Hutchison, AM, 2013) |
| ") administration of the central analgesics fentanyl and dipyrone, and also mediators of pain such as L-glutamate, CCK, ATP, phenylephine and analgesic mediator adenosine, slightly penetrating in CNS, in the minimum effective dose (MED) cause the maximal analgesic effect in the tail flick test in rats." | 7.78 | [Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone]. ( Gmiro, VE; Serdiuk, SE, 2012) |
| "Determining the appropriate dose of transdermal fentanyl (TDF) for the alleviation of cancer pain requires determining the factors causing variations in serum fentanyl concentration after TDF treatment." | 7.78 | Population pharmacokinetics of transdermal fentanyl in patients with cancer-related pain. ( Ebinuma, K; Kokubun, H; Matoba, M; Takayanagi, R; Yago, K; Yamada, Y, 2012) |
| "This study sought to prospectively assess fentanyl safety in a large out-of-hospital group, to identify variables associated with post-fentanyl hypotension (HN; systolic blood pressure [SBP] < 90) or hypoxemia (HX; SpO(2) < 90%)." | 7.77 | Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia. ( Krauss, WC; Shah, S; Thomas, SH, 2011) |
| "This study analysed the analgesic effect and changes in vital signs associated with administration of inhaled Methoxyflurane (MTX) and/or intranasal Fentanyl (INF) for prehospital management of visceral pain." | 7.77 | Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. ( Brightwell, R; Johnston, S; Thompson, JA; Wilkes, GJ; Ziman, M, 2011) |
| "We experienced a patient with an ileal artificial anus who suffered from abdominal pain caused by peritoneal dissemination of ovarian cancer, for which slow-release oxycodone was ineffective, but fentanyl patch proved effective." | 7.77 | [A case of pain management using transdermal fentanyl patches for peritoneal carcinomatosis in a patient with small intestine stoma]. ( Iwazaki, M; Masuda, R; Mikami, M; Nishiumi, N; Saito, Y; Tokuda, Y; Yoshino, K, 2011) |
| " Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence." | 7.77 | [Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. ( Fujita, S; Fukae, M; Hata, A; Iwamori, S; Kaji, R; Katakami, N; Masuda, Y; Mifune, Y; Nanjo, S; Orita, H; Otsuka, K; Yamatani, T, 2011) |
| "To identify predictive factors requiring high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone to transdermal fentanyl in patients with cancer pain." | 7.77 | Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone in patients with cancer pain. ( Fujimoto, S; Hosokawa, T; Kanbayashi, Y; Konishi, H; Miki, T; Okamoto, K; Otsuji, E; Takagi, T; Taniwaki, M; Yoshikawa, T, 2011) |
| "The three-cycle fentanyl patch system provided a stable plasma fentanyl concentration and excellent pain relief and should be considered for pain control in cancer patients." | 7.77 | Three-cycle fentanyl patch system contributes to stable control of plasma fentanyl concentration in gynecologic cancer pain patients. ( Kanamori, C; Kanamori, T; Kanzaki, H; Tanaka, Y, 2011) |
| "The FDA has approved a nasal spray formulation of fentanyl (Lazanda-Archimedes) for management of breakthrough pain in adult cancer patients who are already receiving and are tolerant to opioid therapy." | 7.77 | Fentanyl nasal spray (Lazanda) for pain. ( , 2011) |
| "The aim of this study is to investigate cancer patients' response and side effects associated with transdermal therapeutic fentanyl (TTS-F), whose pain was hardly controlled by nonweak/weak opioids in Taiwan." | 7.76 | The use of transdermal fentanyl in cancer pain--a compliance study of outpatients in Taiwan. ( Chen, YJ; Chiou, TJ; Hung, CJ; Liu, CY; Su, YC; Tang, Y; Tzeng, WF; Weng, YC, 2010) |
| " We treated a 50s female with pain and dyspnea from bone metastasis and lymphangitis carcinomatosa after surgery for NSCLC in whom the optimal dosages of transdermal fentanyl (Durotep Patch) were determined by titration with fentanyl injection, and oxycodone hydrochloride (OxyContin) in a short period." | 7.76 | [Successful management of a patient with pain and dyspnea from bone metastasis and lymphangitis carcinomatosa after surgery for non-small cell lung cancer (NSCLC) in whom optimal dosages of transdermal fentanyl were determined by titration with fentanyl i ( Eguchi, K; Gika, M; Inoue, Y; Izawa, N; Nakayama, M; Takeuchi, K, 2010) |
| "For 20 hospitalized patients with cancer pain that could not be controlled by NSAIDs, the fentanyl transdermal patch (1." | 7.76 | Evaluation of analgesic effect and safety of fentanyl transdermal patch for cancer pain as the first line. ( Hoya, Y; Okamoto, T; Yanaga, K, 2010) |
| " Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation." | 7.76 | Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010) |
| "We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain." | 7.76 | High-dose fentanyl patch for cancer pain of a patient with cholangiocarcinoma. ( Jang, HJ; Jung, JY; Kim, HS; Kim, JH; Kim, M; Shin, YC; Sung, CW, 2010) |
| " IV fentanyl PCA was used for pain control in 16 patients with lower extremity, neuropathic/ischaemic pain, scheduled for major lower extremity amputation." | 7.76 | Case report. Intravenous fentanyl patient-controlled analgesia for perioperative treatment of neuropathic/ischaemic pain in haemodialysis patients: a case series. ( Aretha, D; Filos, KS; Karanikolas, M; Kiekkas, P; Monantera, G; Tsolakis, I, 2010) |
| "Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study." | 7.75 | Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009) |
| " The following data points were collected before and after each naloxone dose; blood pressure, heart rate, respiratory rate, RASS score, pain assessment score (recorded as present or absent), midazolam dose, propofol dose and fentanyl dose." | 7.75 | Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit. ( Arpino, PA; Thompson, BT, 2009) |
| "This report describes an infant who was born to a mother with chronic pain treated with fentanyl 100 microg/h transdermal patch throughout her pregnancy and during lactation." | 7.75 | Fentanyl transdermal analgesia during pregnancy and lactation. ( Cohen, RS, 2009) |
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 7.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| "Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain." | 7.75 | Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models. ( Hasegawa, M; Ito, H; Kanemasa, T; Kato, A; Kihara, T; Koike, K; Masuno, K; Matsumoto, M; Matsushima, S; Minami, K; Miyoshi, T; Nakamura, A; Narita, M; Orita, S; Shimada, S; Suzuki, T; Tomii, T; Torii, M, 2009) |
| "The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults." | 7.74 | Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008) |
| "To evaluate the efficacy and safety of fentanyl administered by PCA in children with cancer pain." | 7.74 | Safety and efficacy of fentanyl administered by patient controlled analgesia in children with cancer pain. ( Barone, G; Chiaretti, A; Lazzareschi, I; Liotti, L; Riccardi, R; Ruggiero, A, 2007) |
| " The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl." | 7.74 | [Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation]. ( Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Lin, XB; Peng, YL; Wang, BF, 2007) |
| "The implementation of a fentanyl-based pain management protocol resulted in a marked reduction in time to initial analgesia among trauma patients." | 7.74 | A fentanyl-based pain management protocol provides early analgesia for adult trauma patients. ( Curtis, KM; Fanciullo, G; Henriques, HF; Reynolds, CM; Suber, F, 2007) |
| " Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence of painful CFA-induced paw inflammation." | 7.74 | Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. ( Binder, W; Brack, A; Fischer, O; Mousa, SA; Rittner, HL; Schäfer, M; Shakibaei, M; Shaqura, M; Stein, C; Urban, F; Zöllner, C, 2008) |
| "This retrospective study identified patients with cancer and noncancer pain who had received > or =1 prescription for fentanyl TD or buprenorphine TD (the all-patients groups) from the German IMS Disease Analyzer-mediplus database, which contains all relevant data concerning drug prescriptions from 400 practices in Germany." | 7.73 | Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study. ( Likar, R; Nautrup, BP; Sittl, R, 2005) |
| "The present study was conducted to evaluate the pain development and bone destruction during bone cancer growth in a murine model of bone cancer pain and to evaluate the analgesic efficacy of fentanyl, sufentanil, and morphine in this model." | 7.73 | Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain. ( El Mouedden, M; Meert, TF, 2005) |
| "The purpose of this study was to compare changes in dosages of transdermal (TD) fentanyl and TD buprenorphine in patients with cancer and non-cancer pain." | 7.73 | Changes in the prescribed daily doses of transdermal fentanyl and transdermal buprenorphine during treatment of patients with cancer and noncancer pain in Germany: results of a retrospective cohort study. ( Nautrup, BP; Nuijten, M; Sittl, R, 2005) |
| "The current study was performed to evaluate the effectiveness and safety of transdermal therapeutic system (TTS) fentanyl in the management of acute pain due to oral mucositis in patients receiving stem cell transplantation." | 7.73 | Effectiveness of transdermal fentanyl patch for treatment of acute pain due to oral mucositis in patients receiving stem cell transplantation. ( Bae, NY; Baek, JH; Chae, YS; Kim, DH; Kim, JG; Kim, SY; Lee, KB; Sohn, SK, 2005) |
| " Data from patients with noncancer or cancer pain treated with TD buprenorphine or TD fentanyl for at least 3 months between May 2002 and April 2005 were analyzed." | 7.73 | Patterns of dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: a retrospective data analysis in Germany. ( Nuijten, M; Poulsen Nautrup, B; Sittl, R, 2006) |
| "The present study was undertaken to investigate the possible change in anti-hyperalgesic effect following repeated treatment with morphine or fentanyl using the dose to improve the thermal hyperalgesia under an inflammatory pain-like state." | 7.73 | Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain. ( Hareyama, N; Hashimoto, S; Imai, S; Miyoshi, K; Nakamura, A; Narita, M; Nozaki, H; Suzuki, M; Suzuki, T; Takagi, T, 2006) |
| "The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain." | 7.72 | A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain. ( Kornick, CA; Manfredi, PL; O'Brien, PC; Payne, R; Santiago-Palma, J; Schulman, G; Weigand, S, 2003) |
| "A Markov model was constructed to simulate the resource use and health outcomes of one year of treatment comparing the fentanyl transdermal therapeutic system (fentanyl-TTS) with oral sustained-release (SR) morphine in outpatients with noncancer pain in Denmark." | 7.72 | A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain. ( Andersen, S; Frei, A; Hole, P; Jensen, NH, 2003) |
| "To evaluate driving performance, cognition, and balance in patients with chronic nonmalignant pain before and after the addition of transdermal fentanyl to their treatments." | 7.72 | The effects of transdermal fentanyl on driving, cognitive performance, and balance in patients with chronic nonmalignant pain conditions. ( Besser, M; Crerand, C; Frank, ED; Jalali, S; Menefee, LA; Park, J; Sanschagrin, K, 2004) |
| "The authors previously reported changes in electroencephalographic bicoherence during isoflurane anesthesia combined with epidural anesthesia." | 7.72 | Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia. ( Hagihira, S; Mashimo, T; Mori, T; Takashina, M; Ueyama, H, 2004) |
| "To assess the analgesic safety and efficacy of Transdermal Therapeutic System (TTS)-fentanyl in the treatment of chronic gynecological cancer-related pain." | 7.72 | Evaluation of safety and efficacy of transdermal therapeutic system-fentanyl in adult patients with gynecological cancer-related pain. ( Cheewakriangkrai, C; Katanyoo, K; Lorvidhaya, V; Srisomboon, J; Suprapaphorn, P, 2004) |
| "(1) Some cancer patients suffer occasional breakthrough pain despite well-conducted opiate treatment, warranting the use of immediate-release oral morphine." | 7.71 | Oral transmucosal fentanyl: new preparation. For breakthrough cancer pain when morphine fails. ( , 2002) |
| "The role of the supraspinal endogenous opioid system in pain processing has been investigated in this study using positron emission tomography imaging of [11C]-carfentanil, a synthetic, highly specific mu opioid receptor (mu-OR) agonist." | 7.71 | Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET). ( Bencherif, B; Campbell, JN; Dannals, RF; Frost, JJ; Fuchs, PN; Sheth, R, 2002) |
| "Early and significant reduction in pain (compared to baseline assessments) was achieved in children using intranasal fentanyl by 10 min and sustained throughout the 30 min of observations." | 7.71 | Intranasal fentanyl reduces acute pain in children in the emergency department: a safety and efficacy study. ( Borland, ML; Geelhoed, G; Jacobs, I, 2002) |
| "This open compassionate-use prospective registration study evaluated the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients with cancer-related pain requiring strong opioid analgesia." | 7.71 | Longitudinal follow-up of TTS-fentanyl use in patients with cancer-related pain: results of a compassionate-use study with special focus on elderly patients. ( Desmedt, M; Lossignol, D; Menten, J; Mullie, A, 2002) |
| "This prospective, open-label, before-after trial was designed to compare the efficacy of oral opioids with that of transdermal fentanyl in severe AIDS-related chronic pain, as well as assess barriers, patient satisfaction, and side effects." | 7.71 | Transdermal fentanyl for chronic pain in AIDS: a pilot study. ( Lefkowitz, M; Newshan, G, 2001) |
| "The fentanyl transdermal system (Duragesic) is an opioid analgesic indicated for the management of chronic moderate to severe pain." | 7.71 | Economic evaluation of the fentanyl transdermal system for the treatment of chronic moderate to severe pain. ( Bell, TJ; Dodd, SL; Neighbors, DM; Wilson, J, 2001) |
| "An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain." | 7.71 | Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001) |
| "This multicentre, observational study examined the efficacy of the therapeutic transdermal fentanyl system (TTS-fentanyl) in children requiring opioids for pain in life-threatening disease." | 7.71 | Transdermal fentanyl for pain relief in a paediatric palliative care population. ( Devine, T; Goldman, A; Hunt, A; Phillips, M, 2001) |
| "Continuous fentanyl infusion should be considered for the treatment of cancer pain in patients requiring high doses who become refractory to other opioids, when other opioids cause intolerable adverse effects, when patients have a true morphine allergy, or when high-dose requirements threaten to deplete existing stock of alternate opioids." | 7.70 | Continuous fentanyl infusion: use in severe cancer pain. ( Dunlap, DS; Lenz, KL, 1998) |
| "A transdermal fentanyl patch for the treatment of chronic cancer-related pain is available in four dosages (25, 50, 75, and 100 microg/hr)." | 7.70 | Factors influencing quality of life in cancer patients: the role of transdermal fentanyl in the management of pain. ( Payne, R, 1998) |
| "To study use of Duragesic (fentanyl transdermal system), the only transdermal opioid approved in Canada for treating chronic cancer pain in adults." | 7.69 | Fentanyl transdermal system. Pain management at home. ( Hays, H; Woodroffe, MA, 1997) |
| "A 62-year-old man receiving subcutaneous fentanyl for the management of cancer pain developed generalized central excitation after an overdose of 5000 micrograms of fentanyl." | 7.69 | Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain. ( Bruera, E; Pereira, J, 1997) |
| "To report a case of high transdermal fentanyl dosage requirements in a patient with chronic cancer pain." | 7.68 | High transdermal fentanyl requirements in a patient with chronic cancer pain. ( Lehr, VT; Renaud, EA, 1993) |
| "These results suggest that steady-state serum concentrations are approached by the second dose of TTS(fentanyl) and that the kinetics are stable with repeated dosing." | 7.68 | Transdermal fentanyl for cancer pain. Repeated dose pharmacokinetics. ( Foley, KM; Gupta, SK; Inturrisi, CE; Lapin, J; Layman, M; Portenoy, RK; Southam, MA, 1993) |
| "The author studied the use of intravenous Propofol for the relief of pain." | 7.68 | [Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl]. ( Croston, J; de Henriquez, L; de Jiménez, L; Espinosa, V, 1992) |
| "Perineal pain during the course of routine epidural analgesia with bupivacaine was treated with a 10-ml top-up of either bupivacaine 25 mg, fentanyl 100 micrograms or fentanyl 100 micrograms plus bupivacaine 10 mg, in 46 women in the first stage of labour." | 7.67 | Epidural fentanyl and perineal pain in labour. ( O'Sullivan, G; Reynolds, F, 1989) |
| "Five cancer patients experienced satisfactory pain relief for periods of 3-156 days using continuous transdermal delivery of the narcotic fentanyl." | 7.67 | Transdermal fentanyl for pain control in patients with cancer. ( Dothage, JA; Miser, AW; Miser, JS; Narang, PK; Sindelar, W; Young, RC, 1989) |
| "To investigate the selective role of intraspinal opioids on the perception and modulation of pain, seven subjects with chronic hip or back pain and one subject with C-6 quadriplegia received 25 micrograms of intrathecal fentanyl." | 7.67 | Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain. ( Chabal, C; Jacobson, L; Little, J, 1989) |
| "1 micrograms/kg fentanyl in low back pain patients reduced both sensory intensity and unpleasantness visual analogue scale (VAS) responses to experimental pain evoked by graded 5-sec nociceptive temperature stimuli (45-51 degrees C) as well as VAS-sensory and VAS-affective responses to clinical pain." | 7.67 | A simultaneous comparison of fentanyl's analgesic effects on experimental and clinical pain. ( Harkins, SW; Price, C; Price, DD; Rafii, A, 1986) |
| "The effect of thyrotropin releasing hormone (TRH) on modified neuroleptanesthesia with fentanyl-flunitrazepam was investigated in an open pilot study of 15 neurosurgical patients." | 7.67 | Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man. ( Dangelmaier, R; Glöser, A; Hempel, V; Lenz, G, 1986) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 7.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| "Severe pain is defined as rated seven or greater on a 0 to 10 age-appropriate numeric pain scale or equivalent." | 6.77 | Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial. ( an Fhailí, S; Barrett, MJ; Cronin, J; Grant, T; Hayden, J; McCoy, S; McMahon, C; Murphy, A; O'Sullivan, R; Wakai, A; Walsh, S, 2012) |
| "Patients with chronic cancer pain were randomly assigned to the conversion from continuous intravenous infusion to transdermal fentanyl using two-step taper of the continuous intravenous infusion in 12 h (12-h method) or the conversion in 6 h (6-h method)." | 6.76 | Six- versus 12-h conversion method from intravenous to transdermal fentanyl in chronic cancer pain: a randomized study. ( Hayashi, K; Kamata, M; Kojima, H; Kozai, M; Nomura, M; Sawada, S, 2011) |
| "Of 139 recruited patients, 69% identified an effective dose of sublingual fentanyl ODT (a dosage that successfully treated all episodes of BTcP over two consecutive days) and entered the maintenance phase, during which they were treated for a median of 149." | 6.76 | Long-term effectiveness and tolerability of sublingual fentanyl orally disintegrating tablet for the treatment of breakthrough cancer pain. ( Derrick, R; Dumble, S; Hassman, D; Howell, J; Nalamachu, S; Wallace, MS, 2011) |
| " Adverse events were also recorded." | 6.76 | The efficacy and safety of fentanyl buccal tablet compared with immediate-release oxycodone for the management of breakthrough pain in opioid-tolerant patients with chronic pain. ( Ashburn, MA; Messina, J; Slevin, KA; Xie, F, 2011) |
| " Adverse events were recorded throughout." | 6.76 | Sublingual fentanyl orally disintegrating tablet in daily practice: efficacy, safety and tolerability in patients with breakthrough cancer pain. ( Müller-Schwefe, GH; Überall, MA, 2011) |
| "During maintenance treatment, 70 of 646 patients (11%) discontinued because of adverse events (AEs), 69 of 646 (11%) because of withdrawn consent, and 57 of 646 (9%) because of noncompliance." | 6.75 | Long-term safety and tolerability of fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic pain: an 18-month study. ( Fine, PG; Messina, J; Rathmell, J; Xie, F, 2010) |
| "Fentanyl is an opioid with high lipid solubility, suitable for intravenous, spinal, transmucosal and transdermal administration." | 6.74 | Transdermal fentanyl in cachectic cancer patients. ( Gergov, M; Haakana, S; Heiskanen, T; Kalso, E; Mätzke, S; Vuori, E, 2009) |
| "Breakthrough cancer pain (BTcP) represents an important clinical challenge in the care of patients with cancer." | 6.74 | Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain. ( Bartkowiak, AJ; Derrick, R; Hassman, D; Hayes, TG; Howell, J; Nalamachu, S; Rauck, RL; Reyes, E; Tark, M, 2009) |
| " Any adverse events were recorded; four tolerability endpoints, constipation, nausea, daytime drowsiness, and sleeping disturbances, were assessed daily." | 6.73 | A randomized, open, parallel group, multicenter trial to investigate analgesic efficacy and safety of a new transdermal fentanyl patch compared to standard opioid treatment in cancer pain. ( Heiskanen, T; Hoerauf, KH; Jensen, NH; Krenn, H; Kress, HG; Lundorff, L; Nolte, T; Petersen, R; Rosland, JH; Sabatowski, R; Saedder, EA; Von der Laage, D, 2008) |
| "2% of patients experienced adverse events that were either probably related or very likely to be related to the study drug." | 6.73 | Safety and efficacy of transdermal fentanyl in patients with cancer pain: phase IV, Turkish oncology group trial. ( Aliustaoğlu, M; Altinbaş, M; Altundağ, K; Atahan, L; Cooper, R; Demirkan, B; Kömürcü, S; Manavoğlu, O; Ozdemir, F; Ozkök, S; Pak, Y; Sarihan, S; Turhal, S; Turna, HS; Yavuz, AA; Yaylaci, M, 2007) |
| "In episodes treated with IV-MO, pain intensity decreased from a mean of 6." | 6.73 | Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain. ( Casuccio, A; Ferrera, P; Intravaia, G; Mangione, S; Mercadante, S; Villari, P, 2007) |
| " Pain intensity (PI) (rated on an 11-point pain scale, from 0 = no pain to 10 = worst pain) and other outcomes were assessed before dosing and for 2 hours after dosing." | 6.73 | Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study. ( Hale, M; Messina, J; Simpson, DM; Xie, F, 2007) |
| "Although common treatments for osteoarthritis (OA) pain, such as nonsteroidal antiinflammatory drugs (NSAIDs), simple analgesics, and weak opioids, provide relief in some cases, they fail to control pain or are poorly tolerated in many cases." | 6.72 | Transdermal fentanyl for improvement of pain and functioning in osteoarthritis: a randomized, placebo-controlled trial. ( Langford, R; McKenna, F; Ratcliffe, S; Richarz, U; Vojtassák, J, 2006) |
| " The magnitude of analgesia in the cold pressor model showed some correlation with TDF dosage and comparable effects for the full agonist fentanyl and the partial agonist buprenorphine." | 6.72 | Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. ( Gasser, UE; Koltzenburg, M; Pokorny, R; Richarz, U, 2006) |
| "Fentanyl is a synthetic opioid that can be delivered through a transdermal therapeutic system (TTS)." | 6.71 | Transdermal fentanyl in HSCT patients: an open trial using transdermal fentanyl for the treatment of oral mucositis pain. ( Carrassi, A; Deliliers, GL; Demarosi, F; Lodi, G; Sardella, A; Soligo, D; Volpe, AD, 2004) |
| "Remifentanil is a short acting, potent synthetic opioid that does not accumulate after infusion or repeated bolus doses." | 6.71 | Remifentanil vs fentanyl/morphine for pain and stress control during pediatric cardiac surgery. ( Arana, A; Bell, G; Dickson, U; Marshall, C; Morton, N; Robinson, D, 2004) |
| " Pharmacokinetic parameters were calculated by noncompartment analysis." | 6.71 | Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain. ( Bredenberg, S; Hedner, T; Holmberg, M; Lennernäs, B; Lennernäs, H; Nyström, C, 2005) |
| " In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low." | 6.71 | Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 6.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| "We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease." | 6.70 | Transdermal fentanyl therapy for pains in children with infantile neuronal ceroid lipofuscinosis. ( Heiskala, HJ; Mannerkoski, MK; Pouttu, JA; Santavuori, PR, 2001) |
| "The treatment of cancer pain with transdermal fentanyl can be performed as a long-term therapy and result in good pain relief." | 6.69 | Long-term treatment of cancer pain with transdermal fentanyl. ( Donner, B; Raber, M; Strumpf, M; Zenz, M, 1998) |
| "TTS fentanyl was titrated to pain relief, and patients were followed up for as long as 3 months." | 6.69 | A clinical evaluation of transdermal therapeutic system fentanyl for the treatment of cancer pain. ( Hays, H; Moulin, DE; Sloan, PA, 1998) |
| "To treat cancer pain, physicians often decide to jump directly from step 1 of the World Health Organization (WHO) analgesic ladder to step 3." | 6.69 | Transdermal fentanyl in opioid-naive cancer pain patients: an open trial using transdermal fentanyl for the treatment of chronic cancer pain in opioid-naive patients and a group using codeine. ( Mattern, C; Uitendaal, MP; Vielvoye-Kerkmeer, AP, 2000) |
| "Midazolam was found to be the drug of preference for the majority of patients." | 6.67 | Midazolam versus fentanyl as premedication for painful procedures in children with cancer. ( Conner, K; Dickson, N; Luzins, J; McGorray, S; Reilly, K; Sandler, ES; Weyman, C, 1992) |
| "Alfentanil was used as an adjuvant to midazolam for analgesia in thirty outpatients undergoing colonoscopy." | 6.67 | Pain relief for outpatient colonoscopy: a comparison of alfentanil with fentanyl. ( Holloway, AM; Logan, DA, 1990) |
| "His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy." | 6.50 | [A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014) |
| "Fentanyl is a lipophilic, short-acting, synthetic opioid with a piperidine chemical structure." | 6.45 | The role of fentanyl in cancer-related pain. ( Prommer, E, 2009) |
| " FBT utilizes OraVescent technology to improve bioavailability and speed of drug delivery." | 6.44 | Fentanyl buccal tablet: faster rescue analgesia for breakthrough pain? ( Hanna, M; Lecybyl, R, 2007) |
| "Pain is experienced by most cancer patients and represents an important issue in the clinical setting." | 6.44 | Oral transmucosal fentanyl citrate in cancer pain management: a practical application of nanotechnology. ( Mystakidou, K; Tsiatas, M; Tsilika, E; Vlahos, L, 2007) |
| "The fentanyl buccal tablet is a new sugar-free, easily-administered formulation that uses an effervescent drug delivery system to enhance the rate and extent of fentanyl absorption across the buccal mucosa." | 6.44 | Fentanyl buccal tablet: rapid relief from breakthrough pain. ( Taylor, DR, 2007) |
| "Persistent pain is present to some degree throughout the day and primarily is controlled with around-the-clock medication." | 6.42 | Managing breakthrough pain: a clinical review with three case studies using oral transmucosal fentanyl citrate. ( Palos, G; Rhiner, M; Termini, M, 2004) |
| " However, clinicians should realize that the manufacturer's recommendations for equianalgesic dosing of transdermal fentanyl may result in initial doses that are too low in some patients, and in a titration period that is too long." | 6.41 | An alternative algorithm for dosing transdermal fentanyl for cancer-related pain. ( Breitbart, W; Chandler, S; Eagel, B; Ellison, N; Enck, RE; Lefkowitz, M; Payne, R, 2000) |
| " The dosing interval for these systems is generally 3 days." | 6.41 | Treatment of cancer pain with transdermal fentanyl. ( Gourlay, GK, 2001) |
| "Fentanyl is a synthetic opioid with short-acting analgesic activity after intravenous or subcutaneous administration." | 6.40 | Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control. ( Benfield, P; Jeal, W, 1997) |
| "Alfentanil may cause less intense respiratory depression than equianalgesic doses of fentanyl." | 6.37 | Alfentanil in anesthesia and analgesia. ( Reitz, JA, 1986) |
| "The control group listened to the natural environment and received Fentanyl for pain relief, and the interventional group listened to the Qur'an recitation and received Fentanyl for pain relief." | 5.69 | The Effects of Listening to the Qur'an in the Postoperative Management of the Patients Undergoing Laparoscopic Cholecystectomy in the Day Surgery Unit. ( Abdullah, KL; Ahmad, CA; Atkins, L; Devol, EB; Hussain, A; Maarof, SR, 2023) |
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| " The number of analgesic pump compressions and pain scores at all 4 time points and fentanyl consumption at 48 hours after surgery were significantly lower in the electroacupuncture treatment groups than in the sham electroacupuncture group (P<." | 5.69 | Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial. ( Feng, Y; Hu, S; Jin, Y; Li, Y; Liu, L; Wang, B; Wang, L; Xiong, B; Yu, X, 2023) |
| "IV Lidocaine did not meet the criteria for non-inferiority with lower prehospital pain reduction than fentanyl but was safe and better tolerated as analgesia in ST-elevation myocardial infarction (STEMI)." | 5.69 | LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial. ( Andrew, E; Bernard, S; Brennan, A; Dinh, D; Fernando, H; Lefkovits, J; Milne, C; Myles, PS; Nehme, Z; O'Brien, J; Peter, K; Smith, K; Stephenson, M; Stub, D; Taylor, AJ, 2023) |
| "This study aimed to compare the efficacy of intravenous, intranasal fentanyl and oral sucrose in reducing the pain response during retinopathy of prematurity examinations using premature infant pain profile (PIPP) scores." | 5.69 | Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial. ( Arman, D; Cömert, S; Gül, A; Kara, N; Seymen, Z, 2023) |
| "Analgesia, Fentanyl, Lidocaine spray, Pain, Rib fracture, Tramadol." | 5.69 | Comparison of the Analgesic Efficacy of Lidocaine Spray versus Tramadol and Fentanyl for Pain Control in Rib Fractures. ( Donmez, S; Erdem, AB; Sener, A, 2023) |
| "Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen." | 5.69 | Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023) |
| " The time to extubation, respiratory complications, nausea, pain, and the number of patients receiving fentanyl were comparable between the groups." | 5.69 | The Impact of Head Elevation on Prevalence and Severity of Emergence Cough in Male Patients during Endotracheal Extubation. ( Kim, JE; Kim, JH; Lim, GM; Park, SJ; Park, SY, 2023) |
| "In contrast, withdrawal associated thermal hyperalgesia was found only in mice." | 5.62 | Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021) |
| "Cancer pain was observed in 131 of 160 patients with advanced cancer living at home." | 5.56 | [Analysis of Symptoms Relieved in Addition to Pain after Administration of Oxycodone or Morphine to Patients with Advanced Cancer Living at Home]. ( Watanabe, K, 2020) |
| " Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist." | 5.51 | Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022) |
| "To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1." | 5.51 | Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022) |
| "We tested the following hypothesis: The addition of intranasal fentanyl to the standard practice of local infiltration with lidocaine would provide better pain control than lidocaine alone for adult ED patients undergoing I&D." | 5.51 | A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess. ( Baer, J; Feliciano, C; Friedman, BW; Gupta, C; Latev, A; Sharpe, S, 2022) |
| "This study investigates the effects of COMTval158met gene polymorphism on maternal anxiety and pain during delivery and on the analgesic and anxiety efficacy of dexmedetomidine during delivery." | 5.51 | Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes. ( Feng, YJ; Han, J; Pu, CX; Tang, LJ; Zhang, Y, 2022) |
| "Intranasal fentanyl seems to be a safe and effective alternative to acetaminophen with hydrocodone in reducing pain and improving hydration status in children with painful infectious mouth lesions and poor oral intake." | 5.51 | Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions. ( Chen, JG; Cramm, K; Florez, C; Papa, L; Ramirez, J; Ruffin, TB; Salinero, E, 2022) |
| "Fentanyl has a low molecular weight and is lipophilic making it suitable for transdermal administration." | 5.51 | Unusual case of transdermal fentanyl in cachexia. ( Harrison, S; Kay, S; Lam, D; Pickard, J, 2019) |
| "We used oxycodone hydrochloride to treat a sharp pain resulting from cataplectic cancer in the jejunal tube, but this provided only limited pain relief." | 5.42 | [Efficacy of a fentanyl citrate buccal tablet for esophageal cancer pain management in a patient unable to take oral medication]. ( Baba, H; Fujimura, Y; Nakahara, O; Ohshima, S, 2015) |
| "To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP)." | 5.41 | 'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial. ( Agarwal, R; Chandra, P; Deorari, A; Madathil, S; Sankar, MJ; Thomas, D; Thukral, A, 2021) |
| " NMDA receptor antagonists versus no treatment, placebo, oral sweet solution, or non-pharmacological intervention One RCT evaluated using oral ketamine (10 mg/kg body weight) versus sugar syrup (66." | 5.41 | Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023) |
| " Opioids may result in an increase in episodes of apnea compared to placebo (RR 3." | 5.41 | Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023) |
| " Opioids may result in an increase in episodes of apnea compared to placebo (RR 3." | 5.41 | Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023) |
| " Our review shows that: - There may be little or no difference in pain relief (single dose IN vs IV fentanyl MD 4 mm, 95% CI -8 to 16 at 30 min by 100 mm VAS; multiple doses IN vs IV fentanyl MD 0, 95%CI -0." | 5.41 | Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. ( Austad, B; Iakovleva, E; Munblit, D; Pedersen, SA; Prescott, MG; Simpson, MR; Vallersnes, OM, 2023) |
| "The evidence is very uncertain about the effect of topical anesthetics (lidocaine) compared to no anesthesia on successful lumbar puncture on first attempt, the number of attempts per lumbar puncture, episodes of bradycardia, episodes of desaturation, and occurrence of apnea." | 5.41 | Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants. ( Bruschettini, M; Hedayati, E; Olsson, E; Pessano, S; Romantsik, O, 2023) |
| "Inhaled methoxyflurane for acute pain relief has demonstrated an analgesic effect superior to placebo." | 5.41 | Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study. ( Comelon, M; Draegni, T; Høiseth, LØ; Lenz, H; Rosseland, LA, 2021) |
| "This study aimed to compare analgesic efficacy of intranasal (IN) ketamine to IN fentanyl for moderate to severe pain in children in a pediatric emergency department." | 5.41 | Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. ( Brady, J; Chitnis, SS; Drapkin, J; Fromm, C; Kriss, S; Likourezos, A; Motov, S; Pushkar, I; Quinn, K; Yasavolian, M, 2021) |
| " Although intravenously administered morphine can readily provide rapid and effective prehospital analgesia, oral transmucosal fentanyl citrate (OTFC) is a safe alternative that does not require intravenous access." | 5.38 | Safety and efficacy of oral transmucosal fentanyl citrate for prehospital pain control on the battlefield. ( Fowler, M; Kotwal, RS; McGhee, L; McManus, JG; Pennardt, A; Talbot, TS; Wedmore, IS, 2012) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 5.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "Fentanyl is an opioid initially developed for parenteral administration." | 5.36 | Formulations of fentanyl for the management of pain. ( Grape, S; Lauer, S; Schug, BS; Schug, SA, 2010) |
| "Fentanyl patch is an alternative for children who cannot tolerate morphine." | 5.35 | Fentanyl patch for stable chronic pain in children: new indication. Used fentanyl patches should be handled with care. ( , 2008) |
| "The femur bone cancer pain model was developed by implanting mouse osteolytic tumor cells (NCTC 2472) into the intramedulla of the femur in C3H/HeN mice." | 5.35 | Oxycodone-induced analgesic effects in a bone cancer pain model in mice. ( Ito, H; Kato, A; Kihara, T; Matsumoto, M; Minami, K; Narita, M; Orita, S; Suzuki, T; Tomii, T, 2008) |
| "Pain was well controlled." | 5.35 | Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008) |
| "We sought to evaluate the efficacy of using a quick response (QR) code within video education to guide proper use of fentanyl transdermal patches and control pain, depression, and anxiety levels in cancer patients." | 5.34 | Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. ( Chen, J; Hu, X; Mao, X; Rao, Y; Xuan, Z; Yang, S; Ye, Z; Zhang, Y, 2020) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 5.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| " The bioavailability of fentanyl was statistically different according to patient age." | 5.33 | Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients. ( Astre, C; Bressolle, F; Caumette, L; Coulouma, R; Culine, S; Garcia, F; Pinguet, F; Solassol, I; Thézenas, S, 2005) |
| "Pain affects many cancer patients, and in advanced stages of the disease it can significantly affect the quality of their lives." | 5.33 | Three-cycle fentanyl patch system significantly improves pain control in gynecologic cancer. ( Hayashi, M; Kanamori, C; Kanamori, T; Kanzaki, H; Yorioka, H, 2006) |
| "Fentanyl is a synthetic, lipophilic opioid, more potent than morphine, and achieves peak effects after intravenous administration in 5 minutes." | 5.32 | Intravenous fentanyl for cancer pain: a "fast titration" protocol for the emergency room. ( Martins, M; Soares, LG; Uchoa, R, 2003) |
| "Morphine side effects were reduced in some patients who changed to transdermal fentanyl, but there was no reduction in those who needed high-dose morphine for rescue analgesia." | 5.32 | A study of transdermal fentanyl in cancer pain at Aichi-Cancer Center. ( Hasegawa, M; Hosoda, R; Kamiya, Y; Kato, K; Mizaki, T; Nitta, M; Yamazaki, S, 2004) |
| "Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H." | 5.31 | Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "Most patients suffered from cancer pain and only 11 patients had chronic pain from non-malignant disease." | 5.31 | Transdermal fentanyl for the management of cancer pain: a survey of 1005 patients. ( Brunsch-Radbruch, A; Grond, S; Lehmann, KA; Petzke, F; Radbruch, L; Sabatowski, R, 2001) |
| "To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries." | 5.30 | Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. ( Caruso, M; Florin, TA; Frey, TM; Mittiga, MR; Zhang, N; Zhang, Y, 2019) |
| "Liberalising an intravenous fentanyl treatment protocol applied by ambulance personnel slightly increased the number of patients with sufficient pain relief at hospital arrival without compromising patient safety." | 5.30 | Prehospital intravenous fentanyl administered by ambulance personnel: a cluster-randomised comparison of two treatment protocols. ( Christensen, EF; Friesgaard, KD; Giebner, M; Kirkegaard, H; Nikolajsen, L; Rasmussen, CH, 2019) |
| "Morphine was approximately 7440 times less potent than dihydroetorphine while heroin and fentanyl were approximately 163." | 5.30 | Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain. ( Hairston, CT; Harris, LS; Lutz, PO; Martin, TJ; Porreca, F, 1998) |
| "To assess whether inhaled nitrous oxide is noninferior to intravenous (IV) sedation for pain control during outpatient surgical abortion between 12 and 16 weeks of gestation." | 5.27 | Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial. ( Espey, E; Pitotti, J; Sheeder, J; Singh, RH; Teal, S; Thaxton, L, 2018) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 5.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 5.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| "The neurodevelopmental impact of fentanyl given to preterm newborns for pain control is still unknown." | 5.24 | Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation. ( Ancora, G; Faldella, G; Ferrari, F; Garetti, E; Lago, P; Merazzi, D; Pierantoni, L; Pirelli, A, 2017) |
| " Further research is required to determine whether the use of nitrous oxide has a role, and to develop a safe and effective analgesic strategy to fully ameliorate the pain of ROP screening." | 5.22 | Analgesia for retinopathy of prematurity screening: A systematic review. ( Hamilton, DL; Hassan, R; Savant, SV; Thirunavukarasu, AJ, 2022) |
| "To compare pain incidence and changes in pain scores with fentanyl versus placebo as pre-emptive treatment during turning and 30 min post-turning in mechanically ventilated critically ill patients." | 5.22 | Fentanyl as pre-emptive treatment of pain associated with turning mechanically ventilated patients: a randomized controlled feasibility study. ( Baños, JE; Castillo, A; Gich, I; Juanes-Borrego, E; Mancebo, J; Navarro, M; Nicolás-Arfelis, JM; Puntillo, K; Robleda, G; Roche-Campo, F; Rodríguez-Arias, A; Sendra, MÀ; Urrutia, G, 2016) |
| "A higher dose of fentanyl led to significantly decreased pain scores as measured by the numeric rating scale (0." | 5.22 | Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial. ( Bandschapp, O; Dolder, P; Filitz, J; Mauermann, E; Rentsch, KM; Ruppen, W, 2016) |
| "To evaluate the efficacy of oral transmucosal fentanyl citrate (OTFC) in the treatment of dyspnea on exertion in patients with advanced cancer." | 5.20 | A randomized crossover clinical trial to evaluate the efficacy of oral transmucosal fentanyl citrate in the treatment of dyspnea on exertion in patients with advanced cancer. ( Bruera, E; Correas, MÁ; Moralo, MJ; Pinna, MÁ; Vargas, RM, 2015) |
| "To compare the effectiveness and safety of fentanyl with placebo as pre-emptive treatment for pain associated with turning in patients in intensive care units." | 5.20 | A randomized controlled trial of fentanyl in the pre-emptive treatment of pain associated with turning in patients under mechanical ventilation: research protocol. ( Baños, JE; Castillo, A; Gich, I; Juanes-Borrejo, E; Mancebo, J; Navarro, M; Robleda, G; Roche-Campo, F; Rodríguez-Arias, A; Sendra, MÀ; Urrútia, G, 2015) |
| "Transdermal fentanyl is an effective, convenient, and well-tolerated treatment for mucositis pain caused by chemoradiotherapy, which can improve ESCC patients' quality of life." | 5.20 | Efficacy and safety of transdermal fentanyl for the treatment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma. ( Xing, SZ; Zhang, Y, 2015) |
| "To determine the differences by comparing fentanyl and ketamine used in cancer-diagnosed children undergoing painful procedures." | 5.20 | The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial. ( Monsereenusorn, C; Rujkijyanont, P; Traivaree, C, 2015) |
| " Four interventions were used: a standardized time-specific VOE protocol; intranasal fentanyl as the first parenteral pain medication; an SCD pain medication calculator; and provider and patient/family education." | 5.20 | Improving the Management of Vaso-Occlusive Episodes in the Pediatric Emergency Department. ( Barry, K; Champigny, M; Dorfman, D; Kavanagh, PL; Killius, K; Miner, R; Moses, JM; Sobota, A; Sprinz, PG; Wolfgang, TL, 2015) |
| "The aim of this study is to investigate the effects of propofol alone, propofol + remifentanil, and propofol + fentanyl combinations on the total dose of propofol to be administered during ERCP and on the pain scores after the process." | 5.20 | Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP. ( Aydınlı, B; Bozkurt, E; Demir, B; Dişibeyaz, S; Haytural, C; Kazancı, D; Özgök, A; Parlak, E; Saraç, A, 2015) |
| "The sedative effects of dexmedetomidine in the ICU patients treated with ventilator bundle treatment are satisfactory, and it can shorten the duration of mechanical ventilation, extubation time and length of ICU stay, reduce the incidence of delirium." | 5.20 | [A study of using dexmedetomidine in ventilator bundle treatment in an ICU]. ( Dong, C; Li, J; Song, R; Yang, J, 2015) |
| "Managing cancer pain often requires opioid medications, such as fentanyl, which is frequently initiated parenterally, and then converted to transdermal form." | 5.19 | Efficacy and safety of a six-hour continuous overlap method for converting intravenous to transdermal fentanyl in cancer pain. ( Bloise, R; Davis, MP; Samala, RV, 2014) |
| "This study used a 60-s venous occlusion technique to evaluate the effectiveness of pretreatment with lidocaine, fentanyl, or remifentanil in preventing pain-induced withdrawal caused by intravenous injection of rocuronium bromide during the induction of general anesthesia." | 5.19 | Pretreatment with remifentanil, fentanyl, or lidocaine to prevent withdrawal after rocuronium using venous occlusion technique in children and adolescents: a prospective randomized placebo-controlled double-blind study. ( Abu-Halaweh, AS; Abu-Halaweh, SA; Al Zaben, KR; Al-Hussami, MO; Aloweidi, AK; Qudaisat, IY, 2014) |
| "Furthermore, in patients where a shift to a fentanyl patch was possible, good long-term pain control was achieved." | 5.19 | [Opioid induction using rapid release drugs and the shift to fentanyl patches]. ( Ejima, M; Morohashi, T; Nakayama, H; Otsuka, Y; Sasaki, S; Suzuki, N; Terai, E; Tsujikawa, Y; Watanabe, T; Yoshimura, K, 2014) |
| "To evaluate the pain on injection of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy." | 5.19 | Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy. ( Bao, Y; Shi, D; Zhang, L, 2014) |
| "Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl." | 5.19 | [Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014) |
| "Sublingual fentanyl proved inadequate in relieving pain during BMAB as no significant differences in the pain scores of the fentanyl and placebo patients were observed." | 5.17 | Pre-medication with sublingual fentanyl did not relieve pain associated with bone marrow aspiration and biopsy: a randomized feasibility trial. ( Ebeling, F; Kuivalainen, AM; Rosenberg, PH, 2013) |
| "Twenty-two healthy males were included in a randomized study to assess the changes in EPs after 110 sweeps of painful electrical stimulation to the median nerve following treatment with buprenorphine, fentanyl or placebo patches." | 5.17 | A novel approach to pharmaco-EEG for investigating analgesics: assessment of spectral indices in single-sweep evoked brain potentials. ( Andresen, T; Arendt-Nielsen, T; Drewes, AM; Gram, M; Graversen, C; Mørch, CD; Nielsen, AK, 2013) |
| "In very preterm infants on mechanical ventilation, continuous fentanyl infusion plus open-label boluses of fentanyl does not reduce prolonged pain, but does reduce acute pain and increase side effects compared with open-label boluses of fentanyl alone." | 5.17 | Efficacy and safety of continuous infusion of fentanyl for pain control in preterm newborns on mechanical ventilation. ( Ancora, G; Faldella, G; Garetti, E; Lago, P; Mastrocola, M; Merazzi, D; Pierantoni, L; Pirelli, A, 2013) |
| "The study aimed to evaluate the effects of the pretreatment with lidocaine, fentanyl, and remifentanil using a venous occlusion technique in preventing pain caused by intravenous injection of rocuronium during induction of general anesthesia." | 5.17 | Comparison of three methods of preventing rocuronium induced pain on injection using venous occlusion technique: a randomized prospective double blind controlled study. ( Abu-Halaweh, NS; Abu-Halaweh, SA; Al-Hussami, MO; Al-Mustafa, M; Aloweidi, AK; Atyat, BS; Qudaisat, IY, 2013) |
| "The addition of fentanyl 1 mcg/kg to propofol for brief painful procedures reduces movement, propofol dose, and recovery time." | 5.17 | Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer. ( Anghelescu, DL; Burgoyne, LL; Faughnan, LG; Hankins, GM; Pui, CH; Smeltzer, MP, 2013) |
| "Patients with bone-cancer pain, already on opioids, obtain clinically important, additional pain-control, with regular oxycodone/paracetamol dosing." | 5.16 | Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial. ( Fang, WX; Li, F; Sima, L; Wu, XM, 2012) |
| "The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers." | 5.16 | A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Malver, LP; Mansikka, H; Oksche, A, 2012) |
| "This study compared the efficacy and safety of a 3-day-type transdermal fentanyl patch conversion by the rapid titration method to short-acting oral oxycodone for cancer pain." | 5.16 | [Three-day-type transdermal fentanyl patch conversion by rapid titration method with short-acting oral oxycodone for cancer pain]. ( Fujio, N; Ishikawa, N; Kameyama, M; Watanabe, H; Yamazaki, K, 2012) |
| "A number of transmucosal fentanyl formulations have been developed for the management of breakthrough cancer pain (BTCP)." | 5.16 | Efficacy and safety of fentanyl sublingual spray for the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study. ( Bull, J; Dillaha, L; Geach, J; Parikh, N; Rauck, R; Reynolds, L; Scherlis, M; Stearns, L, 2012) |
| "We prospectively investigated the reduced effects of adverse events caused by sustained-release oral morphine and controlled-release oxycodone after rotating to the fentanyl patch in patients with metastatic breast cancer." | 5.16 | [A pilot study of the reduced effects of adverse events caused by oral morphine and oxycodone after rotating to fentanyl patch in patients with metastatic breast cancer]. ( Fujii, S; Ikeda, M; Koike, Y; Kubo, S; Kurebayashi, J; Mizutou, A; Nakashima, K; Nomura, T; Oota, Y; Saitou, W; Seki, M; Shiiki, S; Shimo, T; Sonoo, H; Tanaka, K; Yamamoto, Y; Yamashita, T, 2012) |
| " Fentanyl patient-controlled analgesia was commenced to allow patients to self-regulate their pain relief." | 5.16 | Randomised trial of magnesium in the treatment of Irukandji syndrome. ( Bonin, R; Cullen, P; Gray, S; Little, M; McCullagh, N; Mulcahy, R; Pereira, P; Seymour, J, 2012) |
| "Data on the treatment of breakthrough cancer pain (BTcP) in patients receiving methadone therapy are lacking." | 5.15 | The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study. ( Arcuri, E; Ferrera, P; Mercadante, S, 2011) |
| "3°C cold water), nerve growth factor-induced muscle soreness and intradermal capsaicin-induced hyperalgesia and allodynia." | 5.15 | Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models. ( Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN, 2011) |
| "Twenty-two healthy volunteers were randomized to treatment with transdermal buprenorphine (20 µg·h(-1), 144 h), fentanyl (25 µg·h(-1), 72 h) or placebo patches in a double-blind, cross-over experimental pain study." | 5.15 | Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain. ( Andresen, T; Arendt-Nielsen, L; Drewes, AM; Mansikka, H; Oksche, A; Staahl, C, 2011) |
| "The combination of fentanyl and lidocaine before pin fixation is useful in preventing severe hemodynamic response to pain stimuli, such as pin fixation, and in increasing total antioxidant levels in the post-fixational period during craniotomy in adults." | 5.15 | Efficacy of fentanyl and/or lidocaine on total antioxidants and total oxidants during craniotomy. ( Alptekin, M; Erkutlu, I; Geyik, M; Gok, A; Mizrak, A; Oner, U; Sen, E, 2011) |
| "We recently reported that fentanyl pectin nasal spray (FPNS) provides superior pain relief from breakthrough cancer pain (BTCP) compared with immediate-release morphine sulfate (IRMS), with significant effects by five minutes and clinically meaningful pain relief from 10 minutes postdose." | 5.15 | Consistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain. ( Brooks, D; Davies, A; Elsner, F; Espinosa, J; Fallon, M; Reale, C; Sitte, T, 2011) |
| "The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol." | 5.15 | Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011) |
| "To compare the effectiveness of nitrous oxide/oxygen (N(2)O/O(2)) and fentanyl in relieving pain among patients with an isolated long bone fracture or main joint dislocation of the limbs." | 5.15 | Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial. ( Amini, A; Derakhshanfar, H; Dolatabadi, AA; Hatamabadi, H; Kariman, H; Majidi, A; Shahrami, A; Sheibani, K; Yaseri, M, 2011) |
| "Entonox provides better pain relief and faster recovery than midazolam-fentanyl and so is more effective for colonoscopy." | 5.14 | Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy. ( Culbert, B; Duthie, GS; Gardiner, A; Hughes, M; Maslekar, S, 2009) |
| "This study assessed the long-term safety and tolerability of fentanyl buccal tablet (FBT) in opioid-tolerant patients with cancer and breakthrough pain (BTP) who were either naive to FBT or had completed 1 of 2 previous double-blind, placebo-controlled FBT studies (rollover patients)." | 5.14 | Fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic cancer pain: A long-term, open-label safety study. ( Messina, J; Weinstein, SM; Xie, F, 2009) |
| " However, remifentanil continuous infusion proved to offer significantly more stable pain control compared with the currently used combination fentanyl-midazolam." | 5.14 | Analgesia during abdominal aortic aneurysm endovascular repair: remifentanil vs. fentanyl-midazolam--a randomized controlled trial. ( Barbieri, A; Bonfreschi, V; Coppi, G; D'Amico, R; Giuliani, E; Malagnino, FC; Navi, A; Silingardi, R, 2009) |
| "This trial investigated the efficacy and long-term tolerability of intranasal fentanyl spray (INFS) 50 to 200 microg in the treatment of breakthrough pain in opioid-tolerant patients with cancer." | 5.14 | Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: a phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatmen ( Colberg, T; Kaasa, S; Kaczmarek, Z; Kress, HG; Nolte, T; Orońska, A, 2009) |
| "The efficacy of intranasal fentanyl spray (INFS) was compared with that of oral transmucosal fentanyl citrate (OTFC) for the relief of cancer-related breakthrough pain (BTP) in an open-label, crossover trial." | 5.14 | A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial. ( Camba, MA; Colberg, T; Davies, A; Mercadante, S; Perkins, P; Poulain, P; Radbruch, L; Sitte, T, 2009) |
| "The primary objective of the present study was to determine the effectiveness of intranasal fentanyl analgesia in children aged 1-3 years with acute moderate to severe pain presenting to the ED." | 5.14 | Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia. ( Cole, J; Shepherd, M; Young, P, 2009) |
| "The aim of this study was to compare the efficacy of intravenous pretreatment with fentanyl 50 microg, fentanyl 100 microg, and lidocaine 40 mg, preceded by venous occlusion, for reducing pain on injection of propofol in adult Japanese surgical patients." | 5.14 | A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients. ( Fujii, Y; Itakura, M, 2009) |
| "Fentanyl buccal soluble film (FBSF) has been developed as a treatment of breakthrough pain in opioid-tolerant patients with cancer." | 5.14 | Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study. ( Finn, AL; Gever, LN; North, J; Rauck, R; Tagarro, I, 2010) |
| "In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients." | 5.14 | Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010) |
| "comparison of the fentanyl transdermal patch with injection of local anesthesia for intraoperative/postoperative pain from in-office Thermachoice III ablations." | 5.14 | In-office thermachoice III ablation: a comparison of two anesthetic techniques. ( Antonetti, AG; Chapa, HO; Sandate, J; Suvunrungsi, L; VanDuyne, CP; Venegas, G, 2010) |
| "This study evaluated the efficacy and safety of transdermal fentanyl in the outpatient treatment of head and neck cancer patients with pain caused by radiotherapy." | 5.14 | Transdermal fentanyl for pain caused by radiotherapy in head and neck cancer patients treated in an outpatient setting: a multicenter trial in Taiwan. ( Chang, JT; Chen, YJ; Lee, MS; Lin, CY; Lin, JC; Wang, HM, 2010) |
| "To determine if intranasal (IN) fentanyl is effective at decreasing pain that children feel during catheterization of VCUG when compared with sterile water." | 5.14 | Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography. ( Chung, S; Goldman, RD; Lim, R, 2010) |
| "kg(-1) added to bupivacaine significantly improves the quality of intraoperative analgesia and prolongs postoperative analgesia in children undergoing inguinal hernia repair with spinal anesthesia." | 5.14 | Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair. ( Apiliogullari, S; Duman, A; Duman, I, 2010) |
| "Data were obtained from the open titration phase of a multiple crossover, randomized, double-blind clinical trial comparing oral transmucosal fentanyl citrate with immediate-release oral morphine sulfate for the treatment of cancer-related breakthrough pain." | 5.14 | A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensity. ( Berlin, JA; Farrar, JT; Polomano, RC; Strom, BL, 2010) |
| "The intent of our study was to compare the effects of dexmedetomidine versus midazolam on perioperative hemodynamics, sedation, pain, satisfaction and recovery scores during colonoscopy." | 5.14 | A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation. ( Budak, ET; Dagli, G; Dere, K; Filiz, AI; Ozkan, S; Sucullu, I; Yeyen, S, 2010) |
| "In these women who had undergone breast reduction or augmentation surgery, a single preprocedural dose of intranasal fentanyl was significantly more effective than placebo in reducing pain intensity over the hour after removal of surgical drains." | 5.14 | Pharmacokinetics, analgesic effect, and tolerability of a single preprocedural dose of intranasal fentanyl in patients undergoing drain removal after breast reduction or augmentation surgery: A prospective, randomized, double-blind, placebo-controlled stu ( Fiddelers, AA; Kessels, AG; Marcus, MA; Neef, C; Theunissen, HM; van der Hulst, RR; van der Kuy, PH; Veldhorst-Janssen, NM, 2010) |
| "This randomized, double-blind, crossover study assessed the efficacy and tolerability of a new rapid onset nasal fentanyl formulation (Fentanyl Pectin Nasal Spray; FPNS) for breakthrough cancer pain (BTCP)." | 5.14 | A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain. ( Burton, AW; Gabrail, N; Portenoy, RK; Taylor, D, 2010) |
| "To evaluate the time of onset, overall efficacy, and safety of fentanyl buccal tablet (FBT) for noncancer-related breakthrough pain (BTP) in opioid-tolerant adults over 12 weeks." | 5.14 | A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain. ( Farrar, JT; Messina, J; Portenoy, RK; Xie, F, 2010) |
| "We examined the efficacy and safety of a new transdermal fentanyl citrate patch (HFT-290), which was applied once daily in patients with cancer pain who were receiving a stable dose of once-every-three-day application transdermal fentanyl patch [TDF (72 hr)]." | 5.14 | [A phase II clinical study of once-a-day fentanyl citrate patch in patients with cancer pain--switching from once-every-three-days fentanyl patch to once-a-day fentanyl citrate patch]. ( Hashizume, T; Iseki, M; Iwao, Y; Kitajima, T; Masuda, Y; Matoba, M; Miyazaki, T; Namiki, A; Ogawa, S; Uchida, E, 2010) |
| "The aim of this study was to evaluate the effect and tolerability of low doses of transdermal (TD) fentanyl patches in opioid-naive patients with cancer pain." | 5.14 | Low doses of transdermal fentanyl in opioid-naive patients with cancer pain. ( Adile, C; Aielli, F; Ferrera, P; Ficorella, C; Mercadante, S; Porzio, G, 2010) |
| "The objective was to evaluate the use of a single 2 μg/kg dose of intranasal fentanyl as analgesia for painful orthopedic injuries in children presenting to a pediatric emergency department (ED)." | 5.14 | Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain. ( Adelgais, K; Nelson, D; Saunders, M, 2010) |
| " Simultaneous administration of dexamethasone and fentanyl have been known to decrease the duration of perineal pain but its role in alleviating perineal pain has not been studied." | 5.14 | Fentanyl pretreatment for alleviation of perineal symptoms following preoperative administration of intravenous dexamethasone sodium phosphate--a prospective, randomized, double blind, placebo controlled study. ( Garg, R; Rewari, V; Trikha, A, 2010) |
| "Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0." | 5.13 | Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008) |
| "During the first 12 hr following the procedures, patients experienced significantly less vomiting/retching and less disruption of activity while receiving ondansetron, and recorded significantly lower pain scores while receiving fentanyl." | 5.13 | Pediatric oncology sedation trial (POST): A double-blind randomized study. ( Barr, RD; Buckley, N; Korz, L; Lappan, J; Nagel, K; Willan, AR, 2008) |
| "Fentanyl, a short-acting synthetic opioid, has a pharmacokinetic profile suited to fast relief of brief episodic pain." | 5.13 | Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. ( Christrup, L; Foster, D; Popper, L; Upton, R, 2008) |
| "We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy." | 5.13 | Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008) |
| "We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro." | 5.13 | Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine. ( Ahmad, N; Balan, S; Zanariah, Y, 2008) |
| "Activation of DA and opioid neurotransmission by a pain stressor with and without placebo (changes in the binding potential of carbon 11 [11C]-labeled raclopride and [11C] carfentanil with positron emission tomography) and ratings of pain, affective state, and anticipation and perception of analgesia." | 5.13 | Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. ( Egnatuk, CM; Koeppe, RA; Scott, DJ; Stohler, CS; Wang, H; Zubieta, JK, 2008) |
| "Fifty-eight patients who were undergoing SWL for renal calculi were randomized to receive intravenously either fentanyl citrate (group A, n = 30) or parecoxib sodium (group B, n = 28) when they felt that their pain during the session became intolerable." | 5.13 | Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium. ( Anagnostou, T; Gravas, S; Karatzas, A; Melekos, MD; Mitsogiannis, IC; Poulakis, V; Tzortzis, V, 2008) |
| "To compare the efficacy of fentanyl and remifentanil as prodrugs in the prevention of rocuronium injection pain by using a control group." | 5.13 | Comparison of the effectiveness of pretreatment by fentanyl and remifentanil on rocuronium induced injection pain. ( Bayindir, S; Ellidokuz, H; Gunerli, A; Iyilikci, L; Sari, M, 2008) |
| "Fentanyl is a synthetic opioid used to treat intense chronic pain." | 5.13 | Determination of fentanyl in sweat and hair of a patient using transdermal patches. ( Ait-M-Bark, Z; Appenzeller, B; Lemmer, P; Schneider, S; Schummer, C; Wennig, R; Yegles, M, 2008) |
| " administration of fentanyl in acute, episodic pain in patients undergoing third-molar extraction." | 5.13 | Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study. ( Christrup, LL; Foster, D; Popper, LD; Troen, T; Upton, R, 2008) |
| "A novel transdermal matrix patch delivery system for fentanyl has been developed to deliver improved management of cancer pain compared with that obtained using current fentanyl reservoir patches." | 5.13 | Efficacy, safety and pharmacokinetic study of a novel fentanyl-containing matrix transdermal patch system in Japanese patients with cancer pain. ( Hanaoka, K; Hosokawa, T; Ishida, T; Kitajima, T; Mashimo, S; Miyazaki, T; Namiki, A; Nogami, S; Ogawa, S, 2008) |
| "The comparison of ketamine with fentanyl for pain control of pediatric orthopedic emergencies remains controversial." | 5.12 | Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. ( Qiu, J; Xie, M, 2021) |
| " The patient is a 50-year-old female with widely metastatic breast cancer who developed opioid toxicity when maintenance transdermal fentanyl patch therapy (100 μg patch applied every 72 h) was rotated to subcutaneous hydromorphone infusion to improve pain control." | 5.12 | Opioid rotation from transdermal fentanyl to continuous subcutaneous hydromorphone in a cachectic patient: A case report and review of the literature. ( Chua, D; Jackson, LD; Selby, D; Wortzman, R, 2021) |
| "In this study, the analgesic efficiency and adverse events of oxycodone and other opioids, including alfentanil, sufentanil, fentanyl, and morphine, in treating post-laparoscopic surgery visceral pain were evaluated." | 5.12 | Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis. ( Dou, Z; Li, Y; Ma, J; Ni, J; Wang, Q; Yang, L, 2021) |
| "These finding suggest that use of PCEA with bupivacaine and fentanyl is more effective in managing pain related to HDR brachytherapy for prostate cancer, and results in a positive patient outcome thereby improving patient satisfaction." | 5.12 | Prostate HDR radiation therapy: a comparative study evaluating the effectiveness of pain management with peripheral PCA vs. PCEA. ( Block, M; Colella, J; Galli, B; Gejerman, G; Knorr-Mulder, C; Lanteri, V; Levey, S; Sawczuk, I; Scheuch, J; Scrofine, S; Siegel, A; Watson, R, 2006) |
| "This trial demonstrated that the lower 12 microg/h dose of fentanyl TTS provided a therapeutic benefit in non-malignant chronic pain, with a similar AE rate but a lower drop-out rate than that seen in trials at higher doses." | 5.12 | A Phase III study to assess the clinical utility of low-dose fentanyl transdermal system in patients with chronic nonmalignant pain. ( Otis, J; Rothman, M, 2006) |
| "The routine use of fentanyl and midazolam prior to sheath removal leads to a reduction in pain perception and vasovagal incidence, whilst the routine use of local infiltration during sheath removal should be discouraged as it leads to more pain and a trend to more vasovagal reactions." | 5.12 | Effect of local anesthesia and intravenous sedation on pain perception and vasovagal reactions during femoral arterial sheath removal after percutaneous coronary intervention. ( French, JK; Juergens, CP; Kiat Ang, C; Leung, DY; Lo, S, 2007) |
| "We compare the efficacy of intranasal fentanyl versus intravenous morphine in a pediatric population presenting to an emergency department (ED) with acute long-bone fractures." | 5.12 | A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. ( Borland, M; Jacobs, I; King, B; O'Brien, D, 2007) |
| "2% ropivacaine hydrochloride without bolus administration reduces the incidence of hypotension by 67% and is safer than traditional bolus dosing for routine labor." | 5.12 | Hemodynamic stability during labor and delivery with continuous epidural infusion. ( Gerhardt, MA; Gunka, VB; Miller, RJ, 2006) |
| "Acceptable operative conditions with a low incidence of hypotension are provided with an 11 mg dose of hyperbaric bupivacaine." | 5.12 | [Hyperbaric bupivacaine: a randomized double-blind trial of different doses with or without fentanyl for cesarean section under spinal anesthesia]. ( Abengochea Cotaina, A; Bernat García, J; Gallego García, J, 2007) |
| "Fifty-six adults with chronic noncancer pain using oral transmucosal fentanyl citrate (OTFC, ACTIQ)." | 5.12 | Impact of breakthrough pain on quality of life in patients with chronic, noncancer pain: patient perceptions and effect of treatment with oral transmucosal fentanyl citrate (OTFC, ACTIQ). ( Chun, SY; Fortner, B; Reinking, J; Shoemaker, S; Stegman, M; Taylor, DR; Webster, LR, 2007) |
| "Patients experiencing pain during daily dressing changes were given entonox plus either placebo or oral transmucosal fentanyl citrate (OTFC) for two consecutive dressing changes in a randomised double-blind placebo-controlled crossover trial." | 5.12 | Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial. ( Barker, L; Larsen, D; MacIntyre, PA; Margetts, L, 2007) |
| " Here we examined the time-course of changes in BP during a nonpharmacological challenge, moderate levels of sustained pain, shown to induce robust reductions in micro-opioid and DA D2 BP, as measured with [(11)C]carfentanil and [(11)C]raclopride." | 5.12 | Time-course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge. ( Koeppe, RA; Scott, DJ; Stohler, CS; Zubieta, JK, 2007) |
| " This is the first study to investigate the absorption profile of fentanyl buccal tablet (FBT) - an effervescent formulation of fentanyl indicated for the management of breakthrough pain in opioid-tolerant cancer patients - in patients with or without oral mucositis." | 5.12 | Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study. ( Darwish, M; Jiang, JG; Kirby, M; Robertson, P; Tracewell, W, 2007) |
| "The use of OTFC can provide improved pain control when compared with IV morphine." | 5.12 | A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007) |
| "To compare the pain relief achieved with nebulized fentanyl citrate with intravenous (i." | 5.12 | Randomized clinical trial of nebulized fentanyl citrate versus i.v. fentanyl citrate in children presenting to the emergency department with acute pain. ( Biros, MH; Herold, M; Hubbard, D; Kletti, C; Miner, JR, 2007) |
| " In this randomized open-label study the influence of tramadol on dose adjustment of transdermal fentanyl in advanced cancer pain control was prospectively evaluated." | 5.12 | Improved cancer pain treatment using combined fentanyl-TTS and tramadol. ( Aloisio, L; Bajocco, C; Ciccozzi, A; Coaccioli, S; Colangeli, A; Marinangeli, F; Paladini, A; Varrassi, G, 2007) |
| "Various strategies have been studied to reduce the discomfort of rocuronium pain." | 5.12 | Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine. ( Bithal, PK; Chauhan, H; Dash, HH; Prabhakar, H; Rath, GP; Singh, M, 2007) |
| "To compare the effects of providing analgesia with either transdermal fentanyl (TTS-fentanyl) or paracetamol and codeine (P/C) in addition to radiotherapy in patients with metastatic bone pain." | 5.11 | Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life. ( Eleftheriadis, N; Georgakopoulos, G; Gompakis, N; Kouloulias, VE; Kouvaris, J; Mystakidou, K; Pistevou-Gompaki, K; Varveris, C, 2004) |
| "To determine the safety and efficacy of transdermal fentanyl for pain relief in cancer patients and to compare the effects on patients according to whether they had previously received strong opioids, weak opioids or non-opioid analgesia." | 5.11 | Use of transdermal fentanyl without prior opioid stabilization in patients with cancer pain. ( Bryuzgin, V; Kourteva, G; Tawfik, MO, 2004) |
| "The aim of this observational study was to examine pain management outcomes and quality of life (QoL) measures in cancer patients with intolerable or chronic severe pain transferring from World Health Organization's step I, II, and III analgesics to the transdermal therapeutic fentanyl system (TTS-F)." | 5.11 | Pain management of cancer patients with transdermal fentanyl: a study of 1828 step I, II, & III transfers. ( Georgaki, S; Katsouda, E; Kouloulias, V; Kouvaris, J; Mystakidou, K; Parpa, E; Tsilika, E; Vlahos, L, 2004) |
| "This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients." | 5.11 | A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004) |
| "In this randomized, double-blinded study in 60 ASA I or II adults with >20% body-surface area thermal burns, we investigated the feasibility of patient-controlled analgesia (PCA) with fentanyl for pain management during dressing changes and determined the optimal PCA-fentanyl demand dose." | 5.11 | Patient-controlled analgesia with fentanyl for burn dressing changes. ( Fatima, T; Pawar, M; Prakash, S, 2004) |
| "Sufentanil, a potent mu-opioid agonist, historically has not been been given systemically to treat chronic pain." | 5.11 | Relative analgesic potency of fentanyl and sufentanil during intermediate-term infusions in patients after long-term opioid treatment for chronic pain. ( Charapata, S; DuPen, S; Fisher, DM; Heinze, E; Katz, N; Portenoy, R; Rauck, R; Reynolds, L; Wallace, M; Webster, L, 2004) |
| "Oral transmucosal fentanyl citrate can provide an alternative means of delivering effective, rapid-onset, and noninvasive pain management in an out-of-hospital, combat, or austere environment." | 5.11 | A novel pain management strategy for combat casualty care. ( Holcomb, JB; Johnson, TR; Kotwal, RS; Meyer, DE; Mosely, DS; O'Connor, KC, 2004) |
| "Fentanyl is commonly used for spinal analgesia during labour but it is associated with a high incidence of pruritus." | 5.11 | Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron. ( Evans, SF; Paech, MJ; Wells, J, 2004) |
| "We treated 50 patients with chronic nonmalignant pain using transdermal fentanyl (TDF) 25 microg/hr and concurrently measured pain using a visual analog scale (VAS) and serum cortisol concentration." | 5.11 | The effect of transdermal fentanyl treatment on serum cortisol concentrations in patients with non-cancer pain. ( Altan, A; Ozyuvaci, E; Yanmaz Alnigenis, N, 2004) |
| "We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery." | 5.11 | Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004) |
| "This study evaluated transdermal fentanyl (TDF) for the treatment of pain from rheumatoid arthritis (RA) which was not adequately controlled by nonopioid analgesics and/or weak opioids." | 5.11 | Transdermal fentanyl for the treatment of pain caused by rheumatoid arthritis. ( Bjorneboe, O; Herrero-Beaumont, G; Richarz, U, 2004) |
| "A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented." | 5.11 | Urine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches. ( Backer, R; Poklis, A, 2004) |
| " This study observed whether a single dose of 50 mcg intravenous fentanyl reduces pain, improving compliance, acceptability, and completion rates." | 5.11 | Value of fentanyl in flexible sigmoidoscopy. ( Basu, S; Krishnamurthy, B; Walsh, TH, 2004) |
| " Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 5.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
| "To evaluate the effectiveness and safety of transdermal fentanyl (TDF) for the treatment of pain associated with rheumatoid arthritis (RA) or osteoarthritis of the knee or hip (OA), which was not adequately controlled by non-opioid analgesics and/or weak opioids." | 5.11 | Benefits of transdermal fentanyl in patients with rheumatoid arthritis or with osteoarthritis of the knee or hip: an open-label study to assess pain control. ( Bjorneboe, O; Herrero-Beaumont, G; Le Loet, X; Pavelka, K; Richarz, U, 2004) |
| "This study was designed to evaluate the utility of transdermal fentanyl (TDF, Durogesic) for the treatment of pain due to osteoarthritis (OA) of the knee or hip, which was not adequately controlled by non-opioid analgesics or weak opioids." | 5.11 | Transdermal fentanyl for the treatment of pain caused by osteoarthritis of the knee or hip: an open, multicentre study. ( Le Loët, X; Pavelka, K; Richarz, U, 2005) |
| "We evaluated the effects of gabapentin and carbamazepine for pain relief in 36 Guillain-Barré syndrome patients." | 5.11 | The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unit. ( Kumar, A; Navkar, DV; Pandey, CK; Raza, M; Singh, UK; Tripathi, M, 2005) |
| "Although recent studies suggest that opioid rotation could be an effective treatment strategy for morphine-induced delirium, there have been no prospective studies to investigate the treatment effects of opioid rotation using fentanyl." | 5.11 | Opioid rotation from morphine to fentanyl in delirious cancer patients: an open-label trial. ( Akechi, T; Ikenaga, M; Matsubara, T; Miyoshi, I; Morita, T; Onishi, H; Tajima, T; Takigawa, C; Tani, K; Uchitomi, Y, 2005) |
| "Pre-operative administration of oral etoricoxib 120 mg decreased the use of fentanyl and pain scores after minor gynaecological surgery without significant side effects." | 5.11 | Analgesic efficacy of pre-operative etoricoxib for termination of pregnancy in an ambulatory centre. ( Chiu, JW; Lim, Y; Liu, W; Loo, CC; Ren, HZ; Tan, HM, 2005) |
| "Chronic pain can be effectively treated with fentanyl-TTS, which has a very favorable side effect profile." | 5.11 | [Individual aspects of the quality of life of patients with chronic pain. Observational study of treatment with fentanyl-TTS]. ( Waap, I; Zimmermann, M, 2005) |
| "The study objective was to determine whether switching patients from morphine to transdermal fentanyl resulted in a reduction of morphine-associated side effects, and an improvement in cognitive function and patients' well being while maintaining adequate pain and symptom control." | 5.10 | Opioid switching from morphine to transdermal fentanyl for toxicity reduction in palliative care. ( McNamara, P, 2002) |
| "The pain and distress ratings of patients undergoing BMAs (n = 73) and LPs (n = 105) were examined in a comparison of 3 different interventions: (1) a topical eutectic mixture of lidocaine and prilocaine (EMLA cream), (2) oral midazolam and EMLA cream, or (3) propofol/fentanyl general anesthesia." | 5.10 | Pain and distress from bone marrow aspirations and lumbar punctures. ( Doran, NH; Frost, JD; Holdsworth, MT; Mathew, P; Moro, MA; Pankey, JM; Phillips, J; Raisch, DW; Winter, SS, 2003) |
| "When compared with rocuronium alone, only the addition of saline failed to significantly reduce the pain reported by patients." | 5.10 | Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium. ( Chiarella, AB; Clanachan, AS; Huston, CM; Jolly, DT, 2003) |
| " Although the visual analog scale, Observer's Assessment of Alertness/Sedation Scale, and State and Trait Anxiety Inventory-State Anxiety test did not show statistically significant differences, the State and Trait Anxiety Inventory-Trait Anxiety score was found to be lower in the music group (group 2) than in the midazolam group (group 1)." | 5.10 | Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. ( Basar, H; Basar, M; Batislam, E; Ferhat, M; Ozcan, S; Yilmaz, E, 2003) |
| "The findings suggest that a single lumbar epidural dose of fentanyl should be injected at the spinal interspace corresponding to the dermatomal site of pain." | 5.10 | Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain. ( Arendt-Nielsen, L; Curatolo, M; Eichenberger, U; Giani, C; Graven-Nielsen, T; Petersen-Felix, S, 2003) |
| " The addition of a small 125- micro g dose of morphine improves pain control during subsequent epidural analgesia and reduces the requirements for postpartum pain medications." | 5.10 | Small dose bupivacaine-fentanyl spinal analgesia combined with morphine for labor. ( Hess, PE; Pratt, SD; Snowman, C; Vasudevan, A, 2003) |
| "To determine the effects of systemic fentanyl analgesia in preventing the pain related to the administration of retrobulbar anesthesia and cataract surgery." | 5.10 | Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification. ( Ermis, SS; Inan, UU; Oztürk, F; Sivaci, RG, 2003) |
| "To measure the plasma fentanyl concentrations achieved over time with transdermal fentanyl patches in awake cats and cats undergoing anesthesia and ovariohysterectomy." | 5.10 | Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration. ( Allen, SW; Egger, CM; Glerum, LE; Haag, M, 2003) |
| "In an experimental pain study in volunteers, epidural fentanyl caused segmental analgesia when administered as a bolus and nonsegmental systemic analgesia when administered as a continuous infusion." | 5.10 | The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration. ( Angst, MS; Ginosar, Y; Riley, ET, 2003) |
| "This randomised, multicentre, direct open comparative trial evaluated the efficacy, treatment convenience, tolerability and safety aspects of transdermal therapeutic system (TTS)-fentanyl and sustained-release oral morphine (SRM) in both opioid-naïve patients with moderate-to-severe cancer-related pain and in patients who had already been using opioids for mild-to-moderate pain." | 5.10 | Comparison of TTS-fentanyl with sustained-release oral morphine in the treatment of patients not using opioids for mild-to-moderate pain. ( Schipper, RM; Smit, JM; van Seventer, R; Wicks, MA; Zuurmond, WW, 2003) |
| "Transdermal therapeutic system-fentanyl (TTS-F) has been extensively studied in cancer pain management." | 5.10 | Long-term management of noncancer pain with transdermal therapeutic system-fentanyl. ( Georgaki, S; Mavromati, A; Mystakidou, K; Parpa, E; Smyrniotis, V; Tsilika, E; Vlahos, L, 2003) |
| "We conclude that the use of fentanyl (7 microg kg(-1)) was not effective in suppressing the catecholamine release, following painful surgical stimulation in brain-dead organ donors." | 5.10 | Intraoperative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanyl. ( Fitzgerald, RD; Hieber, C; Lackner, FX; Luo, A; Oczenski, W; Schweitzer, E, 2003) |
| "Analgesic treatment with TTS fentanyl used as a single opioid is effective and safe for cancer pain relief, given that is cautiously applied, in patients requiring strong opioid analgesics even if they were naive to strong or mild opioids." | 5.10 | Use of TTS fentanyl as a single opioid for cancer pain relief: a safety and efficacy clinical trial in patients naive to mild or strong opioids. ( Befon, S; Dardoufas, K; Georgaki, S; Mystakidou, K; Tsilika, E; Vlahos, L, 2002) |
| "The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies." | 5.10 | Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002) |
| " In the postanesthesia care unit (PACU), fentanyl 25 microg was administered for a verbal analog scale (VAS) pain score >or=3." | 5.10 | Preoperative administration of controlled-release oxycodone for the management of pain after ambulatory laparoscopic tubal ligation surgery. ( Joshi, W; Maciolek, H; Reuben, SS; Steinberg, RB, 2002) |
| "We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients." | 5.10 | The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "We examined the effects of injection rate of propofol on injection pain and postinduction hypotension and bradycardia when fentanyl was administrated before propofol." | 5.09 | [Effects of speed of injection on anesthesia induction with propofol and fentanyl]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Namiki, A; Seki, S; Tsuchida, A, 1999) |
| ") morphine and fentanyl with respect to pain control and side effects using a 6-day randomized, double-blind, cross-over design." | 5.09 | A comparison of subcutaneous morphine and fentanyl in hospice cancer patients. ( Brooksbank, M; Fazekas, B; Hunt, R; Thorne, D, 1999) |
| "The short duration of effective analgesia produced by intrathecal fentanyl (ITF) at doses ranging from 5 to 25 micrograms limits the drug's use for the management of labor pain." | 5.09 | Effect of intrathecal fentanyl dose on the duration of labor analgesia. ( Celeski, DC; Haas, J; Heindel, L; Vacchiano, CA, 1999) |
| "5 mg bupivacaine given intrathecally via combined spinal epidural (CSE) for labour pain relief in the first stage." | 5.09 | Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine. ( Chen, LH; Chong, JL; Lo, WK, 1999) |
| "Constipation and the use of laxatives were investigated in patients with chronic cancer pain treated with oral morphine and transdermal fentanyl in an open sequential trial." | 5.09 | Constipation and the use of laxatives: a comparison between transdermal fentanyl and oral morphine. ( Grond, S; Kasper, M; Kulbe, C; Lehmann, KA; Loick, G; Radbruch, L; Sabatowski, R, 2000) |
| "Transdermal Fentanyl (TF, Durogesic) is a strong opioid analgesic which is used in the treatment of cancer pain." | 5.09 | [Research from the Palliative Care Department in Poznań on treatment of neoplasm pain with Durogesic (transdermal fentanyl)]. ( Gorzelińska, L; Kozikowska, J; Leppert, W; Luczak, J, 2000) |
| "To compare patients' preference for transdermal fentanyl or sustained release oral morphine, their level of pain control, and their quality of life after treatment." | 5.09 | Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain. ( Allan, L; Bolt, M; de Waroux, BL; Donald, R; Hays, H; Jensen, NH; Kalso, E, 2001) |
| "Our aim was to find out whether intravenous fentanyl was effective in reducing the pain of first-trimester abortion." | 5.09 | A randomized controlled trial of fentanyl for abortion pain. ( Rawling, MJ; Wiebe, ER, 2001) |
| "This open-label study evaluated the long-term safety and tolerability of oral transmucosal fentanyl citrate (OTFC) in ambulatory cancer patients with breakthrough pain undergoing cancer care at 32 university- or community-based practices." | 5.09 | Long-term safety of oral transmucosal fentanyl citrate for breakthrough cancer pain. ( Berris, R; Busch, MA; Coluzzi, P; Hart, L; Loseth, DB; Lyss, A; Nordbrook, E; Payne, R; Portenoy, RK; Rauck, R; Simmonds, M, 2001) |
| "Therapeutic fentanyl blood levels are reached approximately 12-16 hours after the initial application of transdermal fentanyl patches." | 5.09 | A safe and effective method for converting cancer patients from intravenous to transdermal fentanyl. ( Khojainova, N; Kornick, CA; Manfredi, PL; Payne, R; Primavera, LH; Santiago-Palma, J, 2001) |
| "Both etofenamate and fentanyl have clinically sufficient effects on pain, and can be used safely for outpatient ESWL procedures." | 5.09 | Comparative study of etofenamate and fentanyl for outpatient extracorporeal shockwave lithotripsy. ( Bozoklu, A; Cimentepe, E; Sağlam, R; Unsal, A, 2001) |
| "The effects of sublingual fentanyl citrate (SLFC) were assessed in 11 hospice inpatients with cancer-related breakthrough pain." | 5.09 | Sublingual fentanyl citrate for cancer-related breakthrough pain: a pilot study. ( Zeppetella, G, 2001) |
| "The first clinical experience in the United States of the transdermal therapeutic system (TTS) for delivery of fentanyl in cancer pain was a small study of five patients." | 5.08 | Transdermal fentanyl: clinical development in the United States. ( Simmonds, MA, 1995) |
| "To investigate the efficacy and safety of oral transmucosal fentanyl (OTFC) in providing analgesia and sedation for painful diagnostic procedures in children." | 5.08 | The use of oral transmucosal fentanyl citrate for painful procedures in children. ( Bernstein, B; Conard, PL; Rosenblum, M; Schechter, NL; Weisman, SJ, 1995) |
| "Direct conversion from oral morphine to transdermal fentanyl with a ratio of oral morphine/transdermal fentanyl (100:1 mg) daily was examined in patients with cancer pain." | 5.08 | Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain. ( Donner, B; Strumpf, M; Tryba, M; Zenz, M, 1996) |
| "We performed an open-label pilot study to define analgesic efficacy, acceptability, and toxicity of transdermal fentanyl in an ambulatory population of patients with cancer pain." | 5.08 | Transdermal fentanyl in the management of cancer pain in ambulatory patients: an open-label pilot study. ( Fidler, P; Hammack, JE; Loprinzi, CL; Mailliard, JA; Michalak, JC; Miser, AW; O'Fallon, JR; Reuter, NF; Rospond, RM; Wilwerding, MB, 1996) |
| "To compare the local efficacy of lidocaine and fentanyl in reducing propofol injection pain (PIP), we conducted a prospective randomized double-blind study in 75 ASA I and II adult patients." | 5.08 | Reduction of propofol pain--fentanyl vs lidocaine. ( Alyafi, WA; Rangasami, J, 1996) |
| "We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain." | 5.08 | Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997) |
| " A high incidence of pain with drug injection was noted among patients receiving propofol (80%)." | 5.08 | Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients. ( Ganapathy, S; Gelb, AW; Herrick, IA; Kirkby, J, 1997) |
| "A prospective phase II study was conducted to define the analgesic efficacy, acceptability and toxicity of the transdermal therapeutic system (TTS) of fentanyl in Chinese patients with severe cancer-related pain." | 5.08 | Transdermal fentanyl for severe cancer-related pain. ( Chan, AT; Johnson, PJ; Lam, KK; Leung, TW; Nip, SY; Yeo, W, 1997) |
| " This study was designed to: 1) compare the safety and efficacy of intravenous fentanyl, intravenous fentanyl combined with midazolam, and intramuscular meperidine-promethazine-chlorpromazine (MPC) compound when used for painful emergency department (ED) procedures: and 2) to determine whether the addition of et-CO2 monitoring enabled earlier identification of respiratory depression in this population." | 5.08 | The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. ( Berns, SD; Boenning, DA; Hart, LS; Houck, CS, 1997) |
| " pretreatment with fentanyl, morphine, meperidine, or lidocaine in reducing propofol injection pain." | 5.08 | The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study. ( Huang, S; Hwang, MH; Mok, MS; Pang, WW, 1998) |
| "A cohort of patients with cancer who had participated in a placebo-controlled, randomized study that documented the efficacy of oral transmucosal fentanyl citrate for painful procedures rated the pain associated with subsequent procedures performed with open-label oral transmucosal fentanyl." | 5.08 | Consequences of inadequate analgesia during painful procedures in children. ( Bernstein, B; Schechter, NL; Weisman, SJ, 1998) |
| "To compare pain-related treatment satisfaction, patient-perceived side effects, functioning, and well-being in patients with advanced cancer who were receiving either transdermal fentanyl (Duragesic, Janssen Pharmaceuticals, Titusville, NJ) or sustained-release oral forms of morphine (MS Contin, Perdue Frederick Co, Norwalk, CT, or Oramorph SR, Roxanne Laboratories, Columbus, OH)." | 5.08 | Quality of life and cancer pain: satisfaction and side effects with transdermal fentanyl versus oral morphine. ( Mahmoud, R; Mathias, SD; Pasta, DJ; Payne, R; Wanke, LA; Williams, R, 1998) |
| ") retention of fentanyl and lidocaine in reducing the pain on i." | 5.08 | Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain. ( Chang, DP; Chung, YT; Hong, MH; Huang, S; Lin, SS; Pang, WW, 1997) |
| "Patients who were 18 years of age or older, receiving the equivalent of at least 60 mg oral morphine or at least 50 microg transdermal fentanyl per day for chronic cancer-related pain, and experiencing at least one episode of breakthrough pain per day were studied." | 5.08 | Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients. ( Busch, M; Cleary, J; Farrar, JT; Nordbrock, E; Rauck, R, 1998) |
| "Single doses of fentanyl analgesia can reduce the physiologic/behavioral measures of pain and stress associated with mechanical ventilation in preterm infants." | 5.08 | Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates. ( Anand, KJ; de Almeida, MF; Guinsburg, R; Kopelman, BI; Miyoshi, MH; Peres, Cde A, 1998) |
| "Pain on injection is one of the well-known side effects of propofol." | 5.08 | [Pain-free injection of propofol]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Kumagai, A; Namiki, A; Seki, S; Tsuchida, H, 1998) |
| "We compared the effect of fentanyl and lidocaine on pain during injection of propofol." | 5.08 | [Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine]. ( Aketa, K; Ichimiya, T; Kobayashi, Y; Naganuma, R; Namiki, A; Seki, S, 1998) |
| "This was a multicenter, randomized, double-blind, dose-titration study in 62 adult cancer patients using transdermal fentanyl for persistent pain." | 5.08 | Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain. ( Busch, MA; Christie, JM; Coluzzi, P; Nordbrock, E; Patt, R; Portenoy, RK; Simmonds, M, 1998) |
| "To establish the analgesic effective doses as defined as a visual analog pain scale (VAS) of at least 10 for 95% of parturients (ED95) receiving either epidural fentanyl or sufentanil with bupivacaine 0." | 5.08 | Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. ( Gadalla, F; Herman, NL; Koff, HD; Reynolds, JE; Rubin, JD; Sheu, KL; Van Decar, TK, 1998) |
| "All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)." | 5.07 | Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 5.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "The effect of fentanyl, administered immediately before propofol, when pain is experienced at the site of propofol injection was studied in 28 children undergoing elective surgery." | 5.07 | [Fentanyl prevents the pain at the site of propofol injection]. ( Chessa, D; Cossu, F; Serra, G, 1992) |
| "Transdermal fentanyl is a new fentanyl delivery system recently approved by the FDA for use in patients with chronic pain." | 5.07 | Transdermal fentanyl: clinical trial at the University of Colorado Health Sciences Center. ( Slover, R, 1992) |
| "In this study, 6 patients with pain from advanced cancer were enrolled in a multicenter, open-label seeding trial of transdermal fentanyl." | 5.07 | Transdermal fentanyl: seeding trial in patients with chronic cancer pain. ( Kedziera, P; Levy, MH; Rosen, SM, 1992) |
| "Patients were entered into an open label study to evaluate the efficacy of transdermal fentanyl as an analgesic for chronic cancer pain." | 5.07 | Transdermal fentanyl for chronic cancer pain: detailed case reports and the influence of confounding factors. ( Hogan, LA; Patt, RB, 1992) |
| "In this study, 11 cancer patients who experienced severe pain were treated with transdermal fentanyl." | 5.07 | Transdermal fentanyl use in hospice home-care patients with chronic cancer pain. ( Herbst, LH; Strause, LG, 1992) |
| "A multicenter study was conducted to determine the patient and physician acceptability of transdermal fentanyl in the management of cancer-related pain." | 5.07 | Management of cancer pain with transdermal fentanyl: phase IV trial, University of Iowa. ( Barcellos, WA; Maves, TJ, 1992) |
| "To clarify the site of action of epidural fentanyl, we compared the effects of epidural and intravenous fentanyl on the change in pressure pain threshold (PPT) and the minimum alveolar concentration (MAC) of halothane." | 5.07 | Segmental analgesic effect and reduction of halothane MAC from epidural fentanyl in humans. ( Inagaki, Y; Mashimo, T; Yoshiya, I, 1992) |
| "To evaluate the efficacy of opiate administration regimens, 32 patients with multiple rib fractures were prospectively randomized to receive either continuous epidural (ED) or continuous intravenous (IV) infusions of fentanyl." | 5.07 | Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures. ( Davis, JW; Hoyt, DB; Karagianes, TG; Mackersie, RC, 1991) |
| " It was the aim of this study to investigate the analgesic properties of nalbuphine as compared to those of fentanyl, in suppressing the hemodynamic responses due to endotracheal intubation and skin incision." | 5.06 | [Comparative clinical studies of the hemodynamic parameters by anesthesia combination with Nalbuphin (Nubain) and Fentanyl]. ( Dick, W; Heintz-Bamberg, D; Müller, H; Reiter, G, 1987) |
| "To systematically compare the efficacy and safety of sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia (CSEA), a systematic review and meta-analysis of randomized controlled trials targeting parturients requesting labor analgesia was conducted." | 5.05 | Sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia: a systematic review and meta-analysis of randomized controlled trials. ( Diao, Y; Geng, S; Huang, Z; Liu, S; Liu, Y; Shen, L; Su, X; Sun, J; Zhi, M, 2020) |
| "This study evaluated the analgesic efficacy of baclofen in relation to specific pain stimuli in 83 women (27 nulliparas and 56 multiparas) undergoing voluntary abortion (clamping of the cervix and dilatation and curettage)." | 5.05 | Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. ( Bacchini, M; Battagliarin, G; Brambilla, C; Corli, O; Di Piazza, D; Grossi, E; Roma, G, 1984) |
| "To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 5.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
| "Fentanyl citrate is administered intramuscularly at increasing doses to patients suffering from an intense pain in the facial or trigeminal nerves territory." | 5.05 | [Comparison between the analgesic effects of fentanyl and morphine in conscious man (author's transl)]. ( Cathelin, M; Malki, M; Viars, P; Vignes, R, 1980) |
| " Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental." | 5.05 | Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985) |
| "Forty subjects rated the magnitude of painful electrical stimulation of tooth pulp before and after the intravenous administration of either fentanyl, a short-acting narcotic, or a saline placebo." | 5.04 | Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. ( Dubner, R; Gracely, RH; McGrath, PA, 1979) |
| " The examined studies showed that dressing or cream containing morphine could potentially decrease pain, use of analgesics, and side effects associated with systemic opioid medications compared with control groups." | 4.98 | Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials. ( He, GZ; Xu, XM; Yang, C, 2018) |
| "morphine, hydromorphone, fentanyl, trauma, acute pain, intravenous, opioid, pharmacokinetics, and pharmacodynamics." | 4.93 | Opioid Pharmacokinetics-Pharmacodynamics: Clinical Implications in Acute Pain Management in Trauma. ( Ensom, MH; MacKenzie, M; Zed, PJ, 2016) |
| "The objectives of this review were to assess the ability of both pharmacological and non-pharmacological interventions to reduce or eliminate the pain that accompanies rocuronium bromide administration." | 4.93 | Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. ( Ali, Z; Kalaivani, M; Prabhakar, H; Singh, GP; Smith, MA, 2016) |
| " This rapid review, commissioned by the National Institute for Health Research, used standard Cochrane methodology to examine adverse effects of morphine, fentanyl, oxycodone, and codeine in cancer pain studies as a close approximation to possible effects in the dying patient." | 4.90 | Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2014) |
| "To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain." | 4.89 | Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013) |
| "Reports of trials of IN fentanyl in (ED) and prehospital treatment of pain were systematically sought using the PubMed database, Embase, Google scholar, the Cochrane database and the Cumulative Index to Nursing and Allied Health Literature." | 4.89 | Limited evidence for intranasal fentanyl in the emergency department and the prehospital setting--a systematic review. ( Dahl, JB; Hansen, MS, 2013) |
| "The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine." | 4.88 | Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012) |
| "To evaluate the long-term dosing, safety, and tolerability of fentanyl buccal tablet (FBT) in a large cohort of opioid-tolerant patients with chronic noncancer pain and breakthrough pain (BTP)." | 4.87 | Long-term dosing, safety, and tolerability of fentanyl buccal tablet in the management of noncancer-related breakthrough pain in opioid-tolerant patients. ( Janka, L; Nalamachu, SR; Narayana, A, 2011) |
| "Transdermal buprenorphine and fentanyl are now established for moderate-to-severe cancer pain." | 4.87 | Transdermal opioids for cancer pain. ( Ahmedzai, SH; Cachia, E, 2011) |
| "Oral transmucosal fentanyl citrate (OTFC) and fentanyl buccal tablets are the first medications developed specifically for the treatment of breakthrough pain in opioid-tolerant patients." | 4.87 | Fentanyl nasal spray for the treatment of cancer pain. ( Gouliamos, A; Mystakidou, K; Panagiotou, I, 2011) |
| "A short cut review was carried out to establish whether intranasal fentanyl is better than parenteral morphine for managing acute severe pain in children." | 4.87 | Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 4: is intranasal fentanyl better than parenteral morphine for managing acute severe pain in children? ( Kusre, SR, 2011) |
| "To compare the efficacy of intranasal fentanyl spray (INFS), oral transmucosal fentanyl citrate (OTFC), fentanyl buccal tablet (FBT) and oral morphine (OM) for the treatment of breakthrough cancer pain (BTCP)." | 4.86 | Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer. ( Jansen, J; Lenre, M; Nolte, T; Stam, W; Vissers, D, 2010) |
| "Fentanyl is a potent opioid analgesic marketed for the treatment of stable intense chronic pain, particularly in the form of a transdermal patch." | 4.86 | Fentanyl patches: preventable overdose. ( , 2010) |
| "Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects." | 4.86 | Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis. ( Bi, ZF; Chen, DL; Jiang, ZM; Ma, W; Xie, DR; Yang, Q; Zhang, YD, 2010) |
| "Review key aspects of breakthrough pain management with fentanyl buccal tablet, with a focus on minimizing risk to optimize therapeutic outcomes." | 4.86 | Treatment of breakthrough pain with fentanyl buccal tablet in opioid-tolerant patients with chronic pain: appropriate patient selection and management. ( Fine, PG; Narayana, A; Passik, SD, 2010) |
| "Fentanyl, a short-acting synthetic pure opiate, offers an excellent option for the treatment of cancer and chronic pain." | 4.86 | Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications. ( Mystakidou, K; Panagiotou, I, 2010) |
| "Transdermal fentanyl patches first became available in the early 1990s and provided an innovative treatment for the management of cancer pain." | 4.85 | The role of transdermal fentanyl patches in the effective management of cancer pain. ( Gibbs, M, 2009) |
| "The safety of transdermal fentanyl (TF) in comparison with slow-release oral morphine (SROM) in moderate-severe pain was assessed." | 4.85 | Transdermal fentanyl as a front-line approach to moderate-severe pain: a meta-analysis of randomized clinical trials. ( Maltoni, M; Santelmo, C; Sartori, S; Scarpi, E; Tamburini, E; Tassinari, D; Tombesi, P, 2009) |
| "To evaluate the underlying pharmacology, safety, and misuse/abuse of transdermal fentanyl, one of the cornerstone pharmacotherapies for patients with chronic pain." | 4.85 | Transdermal fentanyl: pharmacology and toxicology. ( Nelson, L; Schwaner, R, 2009) |
| "In the present study, we demonstrated that repeated treatment with fentanyl, but not morphine or oxycodone, causes a rapid desensitization to its ability to block the hyperalgesia associated with the attenuation of mu-opioid receptor resensitization in mice in a chronic pain-like state." | 4.84 | [Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state]. ( Hashimoto, S; Kuzumaki, N; Nakamura, A; Narita, M; Ozeki, A; Satoshi, I; Suzuki, T; Uezono, Y, 2008) |
| "To assess the adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison with slow release oral morphine." | 4.84 | Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature. ( Maltoni, M; Raffaeli, W; Sartori, S; Scarpi, E; Tamburini, E; Tassinari, D; Tombesi, P, 2008) |
| "Four studies (393 participants) met the inclusion criteria, all were concerned with the use of oral transmucosal fentanyl citrate (OTFC) in the management of breakthrough pain." | 4.83 | Opioids for the management of breakthrough (episodic) pain in cancer patients. ( Ribeiro, MD; Zeppetella, G, 2006) |
| "Transdermal buprenorphine has been assessed as a therapy for chronic cancer and non-cancer pain in both clinical and postmarketing surveillance studies." | 4.83 | Transdermal buprenorphine in cancer pain and palliative care. ( Sittl, R, 2006) |
| "The fentanyl buccal tablet (FBT) is a new formulation of fentanyl that uses an effervescent drug delivery system to enhance penetration across the buccal mucosa for the treatment of breakthrough pain in opioid-tolerant patients with cancer." | 4.83 | Fentanyl buccal tablet: in breakthrough pain in opioid-tolerant patients with cancer. ( Blick, SK; Wagstaff, AJ, 2006) |
| " We review the literature on intranasal administration of fentanyl, meperidine, diamorphine, and butorphanol to treat acute pain." | 4.83 | [Intranasal opioids for acute pain]. ( Añez Simón, C; Fuentes Baena, A; Rodríguez Pérez, A; Rull Bartomeu, M, 2006) |
| "Transdermal fentanyl is effective and well tolerated for the treatment of chronic pain caused by malignancy and non-malignant conditions when administered according to the manufacturer's recommendations." | 4.82 | Benefit-risk assessment of transdermal fentanyl for the treatment of chronic pain. ( Kornick, CA; Moryl, N; Obbens, EA; Payne, R; Santiago-Palma, J, 2003) |
| " Evidence presented in this review shows encouraging results following the administration of methadone, fentanyl or ketamine to patients with difficult pain problems." | 4.82 | Morphine is not the only analgesic in palliative care: literature review. ( Wootton, M, 2004) |
| "To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and randomised controlled (with SRM as comparator) studies of TDF." | 4.82 | Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain. ( Ahmedzai, SH; Allan, LG; Camacho, F; Clark, AJ; Horbay, GL; Richarz, U; Simpson, K, 2004) |
| " In pain studies, mainly the mu-opioidergic agonist [(11)C]-carfentanil and the unspecific opioid receptor antagonist [(11)C]-diprenorphine are applied." | 4.82 | What to learn from in vivo opioidergic brain imaging? ( Berthele, A; Boecker, H; Platzer, S; Sprenger, T; Tölle, TR, 2005) |
| "According to the World Health Organization (WHO) guidelines for patients with moderate or severe pain, morphine has been used as a "gold standard" treatment for cancer pain." | 4.82 | [Basic studies on cancer pain control]. ( Narita, M; Niikura, K; Ozaki, M; Suzuki, T; Yajima, Y, 2005) |
| "In this article, three aspects of recent issues in cancer pain management such as pain assessment, drowsiness with morphine, and problem in home care setting." | 4.81 | [Issues in cancer pain management]. ( Hoka, S; Matoba, M; Murakami, S, 2001) |
| "Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain." | 4.81 | Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001) |
| "ALZA and Crescendo are developing E-TRANS fentanyl, an electrotransport system (ETS) delivery offentanyl that allows self-titration of the drug by the patient, for the potential management of acute pain." | 4.81 | E-TRANS fentanyl. ALZA. ( Mystakidou, K, 2002) |
| " Because all nurses must keep up to date on basic principles of assessment, pain management, and current pharmacologic and nonpharmacologic approaches to pain, AJN and Home Healthcare Nurse are proud to provide our readers with important information about pain management and a new medication recently approved by the FDA: oral transmucosal fentanyl citrate (Actiq)." | 4.80 | Managing breakthrough cancer pain: a new approach. ( Kedziera, P; Rhiner, M, 1999) |
| " The development of a transdermal fentanyl system provided an opportunity to add fentanyl to the armamentarium of strong opioids available for the treatment of cancer pain." | 4.79 | Transdermal fentanyl therapy: system design, pharmacokinetics and efficacy. ( Southam, MA, 1995) |
| "A new method of administration of an opioid was recently registered: fentanyl transdermal (brand name: Durogesic), intended particularly for the indication range 'pain in cancer'." | 4.79 | [Transdermal opioid administration: the pain plaster]. ( Sillevis Smitt, PA; Vecht, CJ, 1997) |
| "To review the use of transdermal fentanyl for the treatment of moderate to severe chronic pain." | 4.78 | Transdermal fentanyl. ( Lopez, JR; Yee, LY, 1992) |
| "Transdermal fentanyl appears to be a safe and practical alternative to short-acting analgesics in the treatment of cancer pain." | 4.78 | Transdermal fentanyl in cancer pain. ( Mosser, KH, 1992) |
| "The physicochemical properties, pharmacology, pharmacokinetics, serum concentrations and clinical effects, adverse effects and contraindications, and dosage of transdermally administered fentanyl are described, and clinical studies evaluating the use of a transdermal fentanyl system in the treatment of postoperative pain and chronic cancer-associated pain are reviewed." | 4.78 | Transdermally administered fentanyl for pain management. ( Calis, KA; Corso, DM; Kohler, DR, 1992) |
| " Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief." | 4.31 | Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating. ( Ishii, H; Kanai, A; Kokubun, H; Tabata, KI, 2023) |
| "To determine if intranasal fentanyl is equally as effective as IV morphine for treating VOC-associated pain in adult SCD patients." | 4.31 | IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis. ( Assad, O; Brown, K; Melnitsky, L; Moses, J; Sherman, V; Zamora, R, 2023) |
| "Fentanyl, a highly potent synthetic opioid used in cancer and non-cancer pain, is approved for various routes of administration." | 4.31 | Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe. ( Bantel, C; Hoffmann, F; Jobski, K, 2023) |
| "Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related pain." | 4.31 | An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management. ( Bahrami, F; De Nys, K; Defraeye, T; Rossi, RM, 2023) |
| " Multiple demographic and psychosocial factors, as well as perhaps provider bias, play into both a patient's perception of pain and the dosage of fentanyl and midazolam they receive during abortion procedures." | 4.31 | The association of patient age, race, and demographic features on reported pain and sedation dosing during procedural abortion: A retrospective cohort study. ( Howard, M; Lee, J; Makar, E; Pace, L, 2023) |
| " Among those on methadone or buprenorphine (N = 108), multivariable logistic regression models examined the association between socio-demographics, MOUD type; and past-30-day use of heroin/fentanyl; crack; benzodiazepines; and pain medications." | 4.31 | Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs. ( Case, P; Green, TC; Hughto, JMW; Moyo, P; Palacios, WR; Rapisarda, SS; Silcox, J; Stopka, TJ; Tapper, A, 2023) |
| "Nalbuphine combined with ropivacaine in epidural block labor has a faster onset of analgesia and has a lower incidence of urinary retention than fentanyl combined with ropivacaine, and nalbuphine shortens the duration of the first and total stages of labor." | 4.31 | Effect of nalbuphine plus ropivacaine on vaginal labor in epidural analgesia. ( Cao, XS; He, QY; Liu, GH; Liu, LW; Ou, LC; Pang, Z; Wen, XJ; Yin, B, 2023) |
| "Fentanyl is a potent analgesic with a rapid onset and short half-life that make it a useful treatment for pain and a lethal drug of abuse." | 4.31 | Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation. ( Hilgendorf, TN; Kandasamy, R; Morgan, MM, 2023) |
| "The aim of this study was to assess the safety of fentanyl analgosedation during therapeutic hypothermia, by evaluating severe adverse effects and possible correlation with the neurodevelopmental outcome." | 4.12 | Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia. ( Bedetti, L; Berardi, A; Della Casa, E; Ferrari, F; Garetti, E; Guidotti, I; Iughetti, L; Lago, P; Lucaccioni, L; Lugli, L; Pugliese, M; Roversi, MF; Spada, C, 2022) |
| "This is a study that is based on network pharmacology, focusing on the pharmacological mechanism of fentanyl in easing pain." | 4.12 | Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology. ( Bi, J; Wan, H; Wang, S; Zhao, J; Zhao, W; Zhou, S, 2022) |
| "Transdermal fentanyl patches are an effective alternative to the sustained release of oral morphine for chronic pain management." | 4.12 | Predicting transdermal fentanyl delivery using physics-based simulations for tailored therapy based on the age. ( Bahrami, F; Defraeye, T; Rossi, RM, 2022) |
| " There was a significant decrease in propofol and fentanyl utilization from 24 hours pretracheostomy to 24 hours posttracheostomy in both dose and number of patients receiving these continuous intravenous medications." | 4.12 | Tracheostomy decreases continuous analgesia and sedation requirements. ( Droege, CA; Elson, NC; Goodman, MD; Hayes, HV; Nomellini, V; Pritts, TA; Salvator, A; Singer, KE; Wallen, TE, 2022) |
| "Positive responses to a fentanyl vaccine were found along with appreciation for the complexity of a vaccine strategy to prevent OD in the setting of pain and uncertain durability." | 4.12 | Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making. ( Blakemore, LM; Cox, R; Dowling, DJ; Kossowsky, J; Levy, O; Levy, S; Needles, EW; Weitzman, ER, 2022) |
| "Intranasal fentanyl offers a means for safe and effective pain management in austere environments." | 4.12 | Intranasal Fentanyl for On-the-Hill Analgesia by Ski Patrol. ( Callas, PW; Lynch, TV; Peterson, TD; Schlein, SM, 2022) |
| "Methoxyflurane is commonly used by ambulance services to treat pain in pregnant women in WA." | 4.12 | Prevalence and Perinatal Outcomes Following In Utero Exposure to Prehospital Emergency Methoxyflurane: A 17-Year Retrospective Cohort Study. ( Kelty, E; Murray, K; Preen, D; Pyle, A; Sanfilippo, F, 2022) |
| " His pain and agitation were difficult to manage but improved after he received ketamine." | 4.12 | Suspected opioid-induced hyperalgesia in an infant following surgery: A case report. ( Efune, PN; Rebstock, SE, 2022) |
| "Opioids like fentanyl remain the mainstay treatment for chronic pain." | 4.12 | Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia. ( Barko, K; Logan, RW; Puig, S; Seney, ML; Shelton, MA, 2022) |
| "It is recommended not to use transdermal fentanyl (Fe) patches (TFP) in cancer cachexia but TFP may be the only available option for pain." | 4.12 | Transdermal fentanyl to parenteral morphine route switch and drug rotation in refractory cancer cachexia. ( Alabdullateef, SH; Almashiakhi, M; Alsirafy, SA; Elyamany, AM; Hassan, AD, 2022) |
| "During the preliminary experiment, all fentanyl concentrations reached the minimum effective concentration (MEC) extrapolated in pigs (fentanylemia ≥0." | 4.02 | Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs. ( Allorge, D; Chetboun, M; Gaulier, JM; Goutchtat, R; Hubert, T; Pattou, F; Wiart, JF, 2021) |
| "Nebulized fentanyl is well established for analgesia but its use for dyspnea requires further investigation." | 3.96 | Nebulized Fentanyl for Dyspnea: A Retrospective Chart Review. ( Cain, J; Coyne, PJ; Dulin, JD; Higgins, EA; Miller, MM; Overstreet, AN; Vaughan, L; Young, AM, 2020) |
| "Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)." | 3.96 | Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020) |
| "Fentanyl has been associated with many drug overdose deaths; its presence in many street drugs has been postulated to be increasing." | 3.96 | Correlation of Fentanyl Positive Drug Screens with Other Medications in Patients from Pain, Rehabilitation and Behavioral Programs. ( Greg Ackerman, RT; Krock, K; Nickley, J; Pesce, A; Tran, K, 2020) |
| "4-Anilidopiperidine class of synthetic opioid analgesics, with it's representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain." | 3.96 | Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines. ( Ivanović, MD; Jevtić, II; Kostić-Rajačić, SV; Savić Vujović, K; Srebro, D; Vučković, S, 2020) |
| "Transdermal fentanyl is a well-used and highly effective form of opioid analgesia for patients suffering with severe chronic pain." | 3.96 | Fentanyl patches: Use and Misuse. ( Langford, NJ, 2020) |
| "This review evaluates current recommendations for pain management in chronic kidney disease (CKD) and end-stage kidney disease (ESKD) with a specific focus on evidence for opioid analgesia, including the partial agonist, buprenorphine." | 3.96 | Pain management in patients with chronic kidney disease and end-stage kidney disease. ( Dember, LM; Jhamb, M; Liebschutz, J; Roy, PJ; Weltman, M, 2020) |
| "Ketorolac is a reasonable non-narcotic alternative to fentanyl which provides equal pain control and does not increase tube occlusion rates." | 3.96 | Perioperative pain control and tympanostomy tube outcomes. ( Adil, E; Irace, AL; Kawai, K; Leung, P; Riley, B, 2020) |
| " However, its analgesic efficacy remains uncertain for painful procedures; therefore, a combination with intranasal fentanyl (INF), an opioid, was suggested." | 3.91 | Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department-With or Without Intranasal Fentanyl? ( Landolt, MA; Seiler, M; Staubli, G, 2019) |
| "We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids." | 3.91 | Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl. ( Acquadro, MA; Cheng, Y; Farah, F; Gerges, FJ; Kalaydjian, A, 2019) |
| "Low prevalence of active prescriptions for opioids for pain at the time of overdose suggests that opioid prescribing plays a limited short-term impact in the current fentanyl-related crisis of overdoses." | 3.91 | Patterns and history of prescription drug use among opioid-related drug overdose cases in British Columbia, Canada, 2015-2016. ( Chong, M; Crabtree, A; Mill, C; Park, M; Schütz, CG; Smolina, K; Zhao, B, 2019) |
| "To test the effectiveness of a premedication protocol using intravenous bolus of 100 μg fentanyl to reduce pain associated with femoral artery closure device placement for neuro-endovascular procedures." | 3.91 | Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement. ( Naseem, N; Qureshi, AI; Saleem, MA; Wallery, SS, 2019) |
| " Fentanyl (77%) and hydromorphone (48%) were the most common intravenous opioids used to manage pain." | 3.91 | Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation. ( Abrams, D; Agerstrand, C; Brodie, D; Dzierba, AL; Madahar, P; Muir, J, 2019) |
| " Even after multiple testing with Bonferroni adjustments, an increase in the analgesic effect of fentanyl in the cold pressor-induced pain test was significantly associated with a greater number of the A allele of the rs7583431 SNP (linear regression, P = ." | 3.88 | Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test. ( Aoki, Y; Fukuda, KI; Hasegawa, J; Hayashida, M; Ichinohe, T; Ikeda, K; Kasai, S; Koukita, Y; Nishizawa, D; Takahashi, K; Yoshida, K, 2018) |
| " Fentanyl as a second choice is mainly reserved for situations of stable pain." | 3.88 | Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands. ( Janssen, DJA; Martens, MJM; Schols, JMGA; van den Beuken-van Everdingen, MHJ, 2018) |
| " Fentanyl, midazolam, and dexmedetomidine were the first choices of agents for analgesic, sedation, and delirium treatment." | 3.85 | A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China. ( Hu, B; Li, JG; Peng, ZY; Rao, X; Wang, J; Zhou, WH, 2017) |
| "Our aim was to evaluate a nurse-initiated pain-management protocol in adult patients with traumatic injuries in the short and in the long term, utilizing fentanyl for severe pain." | 3.85 | Emergency Department Pain Management in Adult Patients With Traumatic Injuries Before and After Implementation of a Nurse-Initiated Pain Treatment Protocol Utilizing Fentanyl for Severe Pain. ( Goslings, JC; Hollmann, MW; Lirk, P; Ridderikhof, ML; Schep, NW; Schyns, FJ, 2017) |
| "To assess the effectiveness of nebulized fentanyl used for analgesia in renal colic." | 3.85 | A retrospective analysis of nebulized versus intravenous fentanyl for renal colic. ( Aygun, A; Bekar, O; Cicek, M; Erdem, E; Imamoglu, M; Karaca, Y; Sahin, A; Tatli, O; Turedi, S; Turkmen, S, 2017) |
| "Phenylpiperidines are a chemical class of drugs with a phenyl moiety directly attached to piperidine." | 3.85 | Current Concepts of Phenylpiperidine Derivatives Use in the Treatment of Acute and Chronic Pain. ( Choi, S; Elbaridi, N; Kaye, AD; Urman, RD, 2017) |
| "To explore analgesic effects of fentanyl and butorphanol on incisional pain in rats and to investigate the pharmacological mechanism of combination." | 3.83 | Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain. ( Chen, Q; Li, P; Liu, GL; Shang, Y; Xu, Y, 2016) |
| "Prediction of the response to transdermal fentanyl (FENtd) before its use for chronic pain is desirable." | 3.83 | Response to intravenous fentanyl infusion predicts subsequent response to transdermal fentanyl. ( Hayashi, N; Kanai, A; Nagahara, Y; Okamoto, H; Suzuki, A, 2016) |
| "We collected OFL and plasma samples from 64 cancer patients on controlled-release (CR) oral morphine, CR oral oxycodone, or transdermal (TD) fentanyl for pain." | 3.81 | Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain. ( Gunnar, T; Heiskanen, T; Kalso, EA; Langel, K; Lillsunde, P, 2015) |
| "Only fentanyl+midazolam significantly attenuated both the clinical pain score and the increase in blood glucose." | 3.81 | Effect of premedication regimen on infant pain and stress response to endotracheal intubation. ( Caldwell, CD; Watterberg, KL, 2015) |
| "Little is known about the efficacy of low-dose transdermal fentanyl (TDF) patches in opioid-naïve patients with moderate-to-severe cancer pain." | 3.81 | The efficacy of low-dose transdermal fentanyl in opioid-naïve cancer patients with moderate-to-severe pain. ( Hwang, IG; Kang, JH; Kim, JH; Kim, WS; Lee, HR; Lee, HY; Lee, KE; Oh, SY; Park, K; Park, SH; Park, YS; Song, SY, 2015) |
| "This study aims to determine whether a pathway designed to facilitate the use of intranasal (IN) fentanyl for long-bone fractures will expedite the delivery of pain medication, decrease the total length of emergency department (ED) stay, and provide faster analgesia compared with intravenous (IV) morphine." | 3.81 | Expedited Delivery of Pain Medication for Long-Bone Fractures Using an Intranasal Fentanyl Clinical Pathway. ( Erikson Ramirez, D; Frazier, SB; Perkins, AM; Schacherer, NM, 2015) |
| " Oxycodone and fentanyl, in relation to the symptoms studied, seem to be safe as used and titrated in routine cancer pain care." | 3.81 | Renal function and symptoms/adverse effects in opioid-treated patients with cancer. ( Christrup, L; Dale, O; Davies, A; Ekholm, O; Kaasa, S; Klepstad, P; Kurita, GP; Lundström, S; Sjøgren, P, 2015) |
| "Intranasal fentanyl seems to be efficient for analgesia in adult patients with renal colic." | 3.81 | Does intranasal fentanyl provide efficient analgesia for renal colic in adults? ( Bakkali, H; Belkouch, A; Belyamani, L; Chouaib, N; Elbouti, A; Rafai, M; Sirbou, R; Zidouh, S, 2015) |
| "Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment." | 3.81 | Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl. ( Barratt, DT; Dale, O; Kaasa, S; Klepstad, P; Somogyi, AA, 2015) |
| "Fentanyl is widely used to relieve cancer pain." | 3.81 | Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of Fentanyl in Patients with Cancer. ( Bista, SR; Good, P; Hardy, J; Haywood, A; Lobb, M; Norris, R; Tapuni, A, 2015) |
| "Pain management with transdermal opioids is a useful choice in light of longer duration of action, being not affected by oral intake, and with less adverse effect Recently, transdermal fentanyl and buprenorphine are permitted for musculoskeletal non-malignant pain as a new indication." | 3.81 | [Transdermal System-Buprenorphine and Fentanyl]. ( Sakurai, H, 2015) |
| "Fentanyl citrate buccal tablets are indicated for the treatment of breakthrough pain (BTP) in cancer, in adults who are receiving maintenance opioid therapy for chronic cancer pain." | 3.80 | Utilization of fentanyl buccal tablets in England: exploring off-label use reported in a cohort study. ( Al-Shukri, M; Fogg, C; Layton, D; Osborne, V; Shakir, SA, 2014) |
| "Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model." | 3.80 | Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014) |
| " infusion of fentanyl in patients with hepatocellular carcinoma (HCC) treated by RFA." | 3.80 | Pain control in patients with hepatocellular carcinoma treated by percutaneous radiofrequency ablation: comparison of the efficacy of one-shot and continuous intravenous fentanyl delivery. ( Ikeda, O; Inoue, S; Kawanaka, K; Nakasone, Y; Tamura, Y; Yamashita, Y; Yokoyama, K, 2014) |
| "This study aimed to investigate whether CYP3A4/5 genetic variants, together with clinical and patient factors, influence serum fentanyl and norfentanyl concentrations and their ratio in cancer pain patients receiving transdermal fentanyl." | 3.80 | Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study. ( Bandak, B; Barratt, DT; Christrup, LL; Dale, O; Kaasa, S; Klepstad, P; Somogyi, AA; Tuke, J, 2014) |
| "It is unknown whether nutritional status influences pain intensity in cancer patients receiving a transdermal fentanyl patch (FP)." | 3.80 | A retrospective study on the influence of nutritional status on pain management in cancer patients using the transdermal fentanyl patch. ( Chiba, T; Kimura, Y; Kudo, K; Tairabune, T; Takahashi, H; Takahashi, K; Wakabayashi, G, 2014) |
| "This study evaluated the efficacy, safety, and quality of life (QoL) measure of transdermal fentanyl (TDF) for moderate-to-severe pain due to oral mucositis caused by chemoradiotherapy in patients with advanced nasopharyngeal carcinoma (NPC)." | 3.80 | Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life. ( Feng, HX; Guo, SP; He, ZY; Li, FY; Sun, JY; Wu, SG; Wu, YJ; Zhou, J, 2014) |
| "Cold pain sensitivity and analgesic effects of fentanyl were related to the SNP and haplotypes of the P2RX7 gene." | 3.80 | Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. ( Fukuda, K; Hasegawa, J; Hayashida, M; Ide, S; Ikeda, K; Kasai, S; Minami, M; Nishizawa, D, 2014) |
| "Morphine, oxycodone, and fentanyl are commonly used to control cancer pain." | 3.80 | Influence of serum albumin levels during opioid rotation from morphine or oxycodone to fentanyl for cancer pain. ( Arakawa, Y; Fukuura, K; Futamura, A; Hayashi, T; Higashiguchi, T; Ikehata, S; Kuki, R; Makihara, T; Matsuzaki, H; Mori, N; Takahashi, H; Yamadaa, S; Yasuda, K, 2014) |
| "Palliative care physicians are accustomed to using transdermal fentanyl patch for cancer pain control but not so familiar with its intravenous administration." | 3.80 | Use of intravenous fentanyl against morphine tolerance in breakthrough cancer pain: a case series and literature review. ( Bruera, E; Hwang, IC; Park, SM, 2014) |
| "Utility functions based on fentanyl's experimental effects on respiration and pain relief were successfully constructed." | 3.79 | Fentanyl utility function: a risk-benefit composite of pain relief and breathing responses. ( Aarts, L; Boom, M; Dahan, A; Fussen, R; Groeneveld, GJ; Hay, J; Neukirchen, M; Olofsen, E; Sarton, E, 2013) |
| "Fentanyl pectin nasal spray is a novel intranasal formulation for the management of breakthrough cancer pain in patients taking and tolerant to opioids for persistent cancer pain." | 3.79 | Fentanyl pectin nasal spray: a novel intranasal delivery method for the treatment of breakthrough cancer pain. ( Bulloch, MN; Hutchison, AM, 2013) |
| ") administration of the central analgesics fentanyl and dipyrone, and also mediators of pain such as L-glutamate, CCK, ATP, phenylephine and analgesic mediator adenosine, slightly penetrating in CNS, in the minimum effective dose (MED) cause the maximal analgesic effect in the tail flick test in rats." | 3.78 | [Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone]. ( Gmiro, VE; Serdiuk, SE, 2012) |
| "Determining the appropriate dose of transdermal fentanyl (TDF) for the alleviation of cancer pain requires determining the factors causing variations in serum fentanyl concentration after TDF treatment." | 3.78 | Population pharmacokinetics of transdermal fentanyl in patients with cancer-related pain. ( Ebinuma, K; Kokubun, H; Matoba, M; Takayanagi, R; Yago, K; Yamada, Y, 2012) |
| "We report our experiences of 2 cases of successful pain management at home by using opioid rotation from a fentanyl preparation to a continuous subcutaneous injection of morphine hydrochloride, at a dose less than the equivalent dose based on the conversion table." | 3.78 | [2 cases of successful symptom management at home by using opioid rotation from a fentanyl preparation to a continuous subcutaneous injection of morphine hydrochloride, at a dose less than the equivalent dose based on the conversion table]. ( Ishii, N; Koyanagi, J; Miyamori, T; Murase, J; Nishi, T; Saka, S; Sato, M; Yamagishi, T, 2012) |
| "This study sought to prospectively assess fentanyl safety in a large out-of-hospital group, to identify variables associated with post-fentanyl hypotension (HN; systolic blood pressure [SBP] < 90) or hypoxemia (HX; SpO(2) < 90%)." | 3.77 | Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia. ( Krauss, WC; Shah, S; Thomas, SH, 2011) |
| "This study analysed the analgesic effect and changes in vital signs associated with administration of inhaled Methoxyflurane (MTX) and/or intranasal Fentanyl (INF) for prehospital management of visceral pain." | 3.77 | Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. ( Brightwell, R; Johnston, S; Thompson, JA; Wilkes, GJ; Ziman, M, 2011) |
| "We experienced a patient with an ileal artificial anus who suffered from abdominal pain caused by peritoneal dissemination of ovarian cancer, for which slow-release oxycodone was ineffective, but fentanyl patch proved effective." | 3.77 | [A case of pain management using transdermal fentanyl patches for peritoneal carcinomatosis in a patient with small intestine stoma]. ( Iwazaki, M; Masuda, R; Mikami, M; Nishiumi, N; Saito, Y; Tokuda, Y; Yoshino, K, 2011) |
| " Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence." | 3.77 | [Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. ( Fujita, S; Fukae, M; Hata, A; Iwamori, S; Kaji, R; Katakami, N; Masuda, Y; Mifune, Y; Nanjo, S; Orita, H; Otsuka, K; Yamatani, T, 2011) |
| "To identify predictive factors requiring high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone to transdermal fentanyl in patients with cancer pain." | 3.77 | Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone in patients with cancer pain. ( Fujimoto, S; Hosokawa, T; Kanbayashi, Y; Konishi, H; Miki, T; Okamoto, K; Otsuji, E; Takagi, T; Taniwaki, M; Yoshikawa, T, 2011) |
| "The three-cycle fentanyl patch system provided a stable plasma fentanyl concentration and excellent pain relief and should be considered for pain control in cancer patients." | 3.77 | Three-cycle fentanyl patch system contributes to stable control of plasma fentanyl concentration in gynecologic cancer pain patients. ( Kanamori, C; Kanamori, T; Kanzaki, H; Tanaka, Y, 2011) |
| "The FDA has approved a nasal spray formulation of fentanyl (Lazanda-Archimedes) for management of breakthrough pain in adult cancer patients who are already receiving and are tolerant to opioid therapy." | 3.77 | Fentanyl nasal spray (Lazanda) for pain. ( , 2011) |
| "The aim of this study is to investigate cancer patients' response and side effects associated with transdermal therapeutic fentanyl (TTS-F), whose pain was hardly controlled by nonweak/weak opioids in Taiwan." | 3.76 | The use of transdermal fentanyl in cancer pain--a compliance study of outpatients in Taiwan. ( Chen, YJ; Chiou, TJ; Hung, CJ; Liu, CY; Su, YC; Tang, Y; Tzeng, WF; Weng, YC, 2010) |
| "Fentanyl is a potent analgesic drug in relieving chronic pain in patients." | 3.76 | Development of a liquid chromatography-isotope dilution mass spectrometry method for quantification of fentanyl in human plasma. ( Gui, YZ; Jia, JY; Li, SJ; Liu, GY; Lu, C; Shi, XJ; Yu, C, 2010) |
| " When fentanyl was subsequently administered to treat her pain, the stridor resolved." | 3.76 | Treating stridor with opioids: a challenging case of paradoxical vocal cord movement. ( Neustein, SM; Rosenblatt, MA; Taitt-Wynter, LM, 2010) |
| " We treated a 50s female with pain and dyspnea from bone metastasis and lymphangitis carcinomatosa after surgery for NSCLC in whom the optimal dosages of transdermal fentanyl (Durotep Patch) were determined by titration with fentanyl injection, and oxycodone hydrochloride (OxyContin) in a short period." | 3.76 | [Successful management of a patient with pain and dyspnea from bone metastasis and lymphangitis carcinomatosa after surgery for non-small cell lung cancer (NSCLC) in whom optimal dosages of transdermal fentanyl were determined by titration with fentanyl i ( Eguchi, K; Gika, M; Inoue, Y; Izawa, N; Nakayama, M; Takeuchi, K, 2010) |
| "For 20 hospitalized patients with cancer pain that could not be controlled by NSAIDs, the fentanyl transdermal patch (1." | 3.76 | Evaluation of analgesic effect and safety of fentanyl transdermal patch for cancer pain as the first line. ( Hoya, Y; Okamoto, T; Yanaga, K, 2010) |
| " Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation." | 3.76 | Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010) |
| "We conducted an online English survey of Canadian neonatologists using Survey Monkey, whereby they answered questions about the frequency and pattern of use of opioids, and specifically, of morphine and fentanyl, for ventilated and spontaneously breathing infants undergoing selected painful medical procedures." | 3.76 | Canadian neonatologist practices regarding opioid use in ventilated and spontaneously breathing infants undergoing medical procedures. ( McNair, C; Pulleyblank, R; Shah, V; Stephens, D; Taddio, A, 2010) |
| "We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain." | 3.76 | High-dose fentanyl patch for cancer pain of a patient with cholangiocarcinoma. ( Jang, HJ; Jung, JY; Kim, HS; Kim, JH; Kim, M; Shin, YC; Sung, CW, 2010) |
| " IV fentanyl PCA was used for pain control in 16 patients with lower extremity, neuropathic/ischaemic pain, scheduled for major lower extremity amputation." | 3.76 | Case report. Intravenous fentanyl patient-controlled analgesia for perioperative treatment of neuropathic/ischaemic pain in haemodialysis patients: a case series. ( Aretha, D; Filos, KS; Karanikolas, M; Kiekkas, P; Monantera, G; Tsolakis, I, 2010) |
| "The aim of this study was to evaluate the equianalgesic ratio of transdermal buprenorphine (TD BUP) with oral morphine and TD fentanyl in a sample of consecutive cancer patients receiving stable doses of 120-240 mg of oral morphine or 50-100 microg of TD fentanyl, reporting adequate pain and symptom control." | 3.75 | Equipotent doses to switch from high doses of opioids to transdermal buprenorphine. ( Casuccio, A; Giarratano, A; Mercadante, S; Tirelli, W, 2009) |
| "Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study." | 3.75 | Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009) |
| " The following data points were collected before and after each naloxone dose; blood pressure, heart rate, respiratory rate, RASS score, pain assessment score (recorded as present or absent), midazolam dose, propofol dose and fentanyl dose." | 3.75 | Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit. ( Arpino, PA; Thompson, BT, 2009) |
| "This report describes an infant who was born to a mother with chronic pain treated with fentanyl 100 microg/h transdermal patch throughout her pregnancy and during lactation." | 3.75 | Fentanyl transdermal analgesia during pregnancy and lactation. ( Cohen, RS, 2009) |
| "We report on a 64-year-old patient in whom fentanyl therapy was found to be responsible for the induction of secondary adrenal insufficiency as clearly demonstrated by re-exposure." | 3.75 | Secondary adrenal insufficiency due to opiate therapy - another differential diagnosis worth consideration. ( Brändle, M; Greminger, P; Schimke, KE, 2009) |
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 3.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| "Transdermal fentanyl (Duragesic, and others) offers a convenient delivery system for patients with chronic pain but it has some drawbacks." | 3.75 | In brief: heat and transdermal fentanyl. ( , 2009) |
| "Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain." | 3.75 | Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models. ( Hasegawa, M; Ito, H; Kanemasa, T; Kato, A; Kihara, T; Koike, K; Masuno, K; Matsumoto, M; Matsushima, S; Minami, K; Miyoshi, T; Nakamura, A; Narita, M; Orita, S; Shimada, S; Suzuki, T; Tomii, T; Torii, M, 2009) |
| "Fentanyl transdermal system is indicated for the management of persistent, moderate-to-severe chronic pain that requires continuous opioid administration for an extended period of time and cannot be managed by other means such as nonsteroidal analgesics, opioid combination products, or immediate-release opioids." | 3.75 | Reducing patient harm with the use of fentanyl transdermal system. ( Gaunt, MJ; Grissinger, M, 2009) |
| "Although fentanyl patches (FP) designed to sustain plasma fentanyl concentrations for 3 days are used in many patients for continuous relief of moderate to severe cancer pain, there are some cases in which effective pain relief is sustained less than for 3 days, and in which plasma fentanyl concentrations rapidly decrease at the third day after the application." | 3.74 | [Measurement of amount of fentanyl remaining in used patches: investigation of clinical factors affecting the remaining amounts in 4 patients]. ( Iguchi, H; Kojima, M; Ohta, T; Yamamoto, K, 2008) |
| "The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults." | 3.74 | Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008) |
| "Fentanyl is a potent synthetic narcotic analgesic administered in the form of a transdermal patch for the management of chronic pain." | 3.74 | LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems. ( Coopman, V; Cordonnier, J; Pien, K; Van Varenbergh, D, 2007) |
| "To evaluate the efficacy and safety of fentanyl administered by PCA in children with cancer pain." | 3.74 | Safety and efficacy of fentanyl administered by patient controlled analgesia in children with cancer pain. ( Barone, G; Chiaretti, A; Lazzareschi, I; Liotti, L; Riccardi, R; Ruggiero, A, 2007) |
| " The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl." | 3.74 | [Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation]. ( Bu, Q; Cai, QQ; Gao, Y; Huang, HQ; Lin, XB; Peng, YL; Wang, BF, 2007) |
| " Patients with far advanced cancer often suffer from sweating and cachexia, which may have negative effects on the absorption of transdermal fentanyl." | 3.74 | Clinical experience with transdermal and orally administered opioids in palliative care patients--a retrospective study. ( Clemens, KE; Klaschik, E, 2007) |
| "The implementation of a fentanyl-based pain management protocol resulted in a marked reduction in time to initial analgesia among trauma patients." | 3.74 | A fentanyl-based pain management protocol provides early analgesia for adult trauma patients. ( Curtis, KM; Fanciullo, G; Henriques, HF; Reynolds, CM; Suber, F, 2007) |
| " Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence of painful CFA-induced paw inflammation." | 3.74 | Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. ( Binder, W; Brack, A; Fischer, O; Mousa, SA; Rittner, HL; Schäfer, M; Shakibaei, M; Shaqura, M; Stein, C; Urban, F; Zöllner, C, 2008) |
| "Indigent patients without prescription coverage trended toward reporting more cancer pain, received lower doses of transdermal fentanyl, and trended to lower adherence to pain regimens due to financial reasons." | 3.74 | Influence of prescription benefits on reported pain in cancer patients. ( Amadio, WJ; Bryan, M; De La Rosa, N; Hill, AM; Wieder, R, 2008) |
| "The experimental setup consisted of a randomized block design with four experimental groups: two light (3/4) minimum alveolar concentration (MAC) isoflurane anesthesia groups (unstimulated/NIWR-stimulated) and two NIWR-stimulated surgical anesthesia groups (1(1/2) MAC isoflurane anesthesia and (3/4) MAC isoflurane anesthesia combined with fentanyl 400-600 microg x kg(-1) x h(-1))." | 3.74 | Suppression of noxious-induced c-fos expression in the rat lumbar spinal cord by isoflurane alone or combined with fentanyl. ( Nguyen, NK; Ritskes-Hoitinga, M; Sommers, MG; van Egmond, J; Veening, JG; Vissers, KC, 2008) |
| "About 61% of the patients suffered from non-cancer pain and 60% used other opioids before start of TTS fentanyl." | 3.73 | Utilisation pattern of fentanyl transdermal system in The Netherlands. ( Breekveldt-Postma, NS; Herings, RM; Penning-van Beest, FJ, 2005) |
| "This retrospective study identified patients with cancer and noncancer pain who had received > or =1 prescription for fentanyl TD or buprenorphine TD (the all-patients groups) from the German IMS Disease Analyzer-mediplus database, which contains all relevant data concerning drug prescriptions from 400 practices in Germany." | 3.73 | Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study. ( Likar, R; Nautrup, BP; Sittl, R, 2005) |
| "The present study was conducted to evaluate the pain development and bone destruction during bone cancer growth in a murine model of bone cancer pain and to evaluate the analgesic efficacy of fentanyl, sufentanil, and morphine in this model." | 3.73 | Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain. ( El Mouedden, M; Meert, TF, 2005) |
| "The purpose of this study was to compare changes in dosages of transdermal (TD) fentanyl and TD buprenorphine in patients with cancer and non-cancer pain." | 3.73 | Changes in the prescribed daily doses of transdermal fentanyl and transdermal buprenorphine during treatment of patients with cancer and noncancer pain in Germany: results of a retrospective cohort study. ( Nautrup, BP; Nuijten, M; Sittl, R, 2005) |
| "The current study was performed to evaluate the effectiveness and safety of transdermal therapeutic system (TTS) fentanyl in the management of acute pain due to oral mucositis in patients receiving stem cell transplantation." | 3.73 | Effectiveness of transdermal fentanyl patch for treatment of acute pain due to oral mucositis in patients receiving stem cell transplantation. ( Bae, NY; Baek, JH; Chae, YS; Kim, DH; Kim, JG; Kim, SY; Lee, KB; Sohn, SK, 2005) |
| "There is a trend to use fentanyl patch as first-choice strong opioid in cancer patients in situations such as titration phase, in the presence of instable pain, and in the absence of dysphagia or gastrointestinal symptoms where the use of oral morphine is, however, not contraindicated." | 3.73 | Is the use of transdermal fentanyl inappropriate according to the WHO guidelines and the EAPC recommendations? A study of cancer patients in Italy. ( Brunelli, C; Campa, T; De Conno, F; Fagnoni, E; Ripamonti, C, 2006) |
| "The use of fentanyl patches has become accepted as standard in Germany for the treatment of chronic and cancer pain." | 3.73 | [Medico-legal aspects of the use of fentanyl patches]. ( Zimmermann, M, 2006) |
| " Data from patients with noncancer or cancer pain treated with TD buprenorphine or TD fentanyl for at least 3 months between May 2002 and April 2005 were analyzed." | 3.73 | Patterns of dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: a retrospective data analysis in Germany. ( Nuijten, M; Poulsen Nautrup, B; Sittl, R, 2006) |
| "The present study was undertaken to investigate the possible change in anti-hyperalgesic effect following repeated treatment with morphine or fentanyl using the dose to improve the thermal hyperalgesia under an inflammatory pain-like state." | 3.73 | Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain. ( Hareyama, N; Hashimoto, S; Imai, S; Miyoshi, K; Nakamura, A; Narita, M; Nozaki, H; Suzuki, M; Suzuki, T; Takagi, T, 2006) |
| "Despite ketoprofen infusion and free access to a patient-controlled pump with fentanyl citrate for rescue analgesia, inadequate pain relief was common both after uvulopalatoplasty (35%) and after tonsillectomy (28%) during the first 24 hours after surgery." | 3.72 | Pain intensity after laseruvulopalatoplasty and tonsillectomy. ( Aho, M; Kokki, H; Nikanne, E; Virtaniemi, J, 2003) |
| "The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain." | 3.72 | A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain. ( Kornick, CA; Manfredi, PL; O'Brien, PC; Payne, R; Santiago-Palma, J; Schulman, G; Weigand, S, 2003) |
| "Although fentanyl has been reported to cause CNS excitation in horses, a transdermal therapeutic system (TTS) containing this mu agonist has recently been used empirically in equine medicine to treat moderate to severe pain." | 3.72 | Pharmacokinetics of fentanyl following intravenous and transdermal administration in horses. ( Kollias-Baker, C; Maxwell, LK; Slovis, N; Thomasy, SM, 2003) |
| "Partial opioid substitution with fentanyl and moderate levels of hydration had no significant preventive effects on the occurrence of agitated delirium in the last week on a mass level." | 3.72 | Agitated terminal delirium and association with partial opioid substitution and hydration. ( Inoue, S; Morita, T; Tei, Y, 2003) |
| "A Markov model was constructed to simulate the resource use and health outcomes of one year of treatment comparing the fentanyl transdermal therapeutic system (fentanyl-TTS) with oral sustained-release (SR) morphine in outpatients with noncancer pain in Denmark." | 3.72 | A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain. ( Andersen, S; Frei, A; Hole, P; Jensen, NH, 2003) |
| "A retrospective cohort design study was conducted to determine the incidence of constipation in chronic pain patients who received three different long-acting opioids (transdermal fentanyl, oxycodone HCl controlled-release [CR], or morphine CR) for malignant or nonmalignant chronic pain." | 3.72 | Incidence of constipation associated with long-acting opioid therapy: a comparative study. ( Markowitz, J; Schein, J; Staats, PS, 2004) |
| "To evaluate driving performance, cognition, and balance in patients with chronic nonmalignant pain before and after the addition of transdermal fentanyl to their treatments." | 3.72 | The effects of transdermal fentanyl on driving, cognitive performance, and balance in patients with chronic nonmalignant pain conditions. ( Besser, M; Crerand, C; Frank, ED; Jalali, S; Menefee, LA; Park, J; Sanschagrin, K, 2004) |
| "The authors previously reported changes in electroencephalographic bicoherence during isoflurane anesthesia combined with epidural anesthesia." | 3.72 | Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia. ( Hagihira, S; Mashimo, T; Mori, T; Takashina, M; Ueyama, H, 2004) |
| "To assess the analgesic safety and efficacy of Transdermal Therapeutic System (TTS)-fentanyl in the treatment of chronic gynecological cancer-related pain." | 3.72 | Evaluation of safety and efficacy of transdermal therapeutic system-fentanyl in adult patients with gynecological cancer-related pain. ( Cheewakriangkrai, C; Katanyoo, K; Lorvidhaya, V; Srisomboon, J; Suprapaphorn, P, 2004) |
| "Transdermal fentanyl is an opioid analgesic that is effective on chronic pain, and which appears to be advantageous due to several factors such as ease of administration, the relatively stable serum concentration and long dose intervals." | 3.72 | Oral transmucosal abuse of transdermal fentanyl. ( Dimopoulos, NP; Gitsa, OE; Liappas, AI; Liappas, IA; Mellos, E; Rabavilas, AD, 2004) |
| "(1) Some cancer patients suffer occasional breakthrough pain despite well-conducted opiate treatment, warranting the use of immediate-release oral morphine." | 3.71 | Oral transmucosal fentanyl: new preparation. For breakthrough cancer pain when morphine fails. ( , 2002) |
| "The role of the supraspinal endogenous opioid system in pain processing has been investigated in this study using positron emission tomography imaging of [11C]-carfentanil, a synthetic, highly specific mu opioid receptor (mu-OR) agonist." | 3.71 | Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET). ( Bencherif, B; Campbell, JN; Dannals, RF; Frost, JJ; Fuchs, PN; Sheth, R, 2002) |
| "Early and significant reduction in pain (compared to baseline assessments) was achieved in children using intranasal fentanyl by 10 min and sustained throughout the 30 min of observations." | 3.71 | Intranasal fentanyl reduces acute pain in children in the emergency department: a safety and efficacy study. ( Borland, ML; Geelhoed, G; Jacobs, I, 2002) |
| "This open compassionate-use prospective registration study evaluated the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients with cancer-related pain requiring strong opioid analgesia." | 3.71 | Longitudinal follow-up of TTS-fentanyl use in patients with cancer-related pain: results of a compassionate-use study with special focus on elderly patients. ( Desmedt, M; Lossignol, D; Menten, J; Mullie, A, 2002) |
| "This prospective, open-label, before-after trial was designed to compare the efficacy of oral opioids with that of transdermal fentanyl in severe AIDS-related chronic pain, as well as assess barriers, patient satisfaction, and side effects." | 3.71 | Transdermal fentanyl for chronic pain in AIDS: a pilot study. ( Lefkowitz, M; Newshan, G, 2001) |
| "The fentanyl transdermal system (Duragesic) is an opioid analgesic indicated for the management of chronic moderate to severe pain." | 3.71 | Economic evaluation of the fentanyl transdermal system for the treatment of chronic moderate to severe pain. ( Bell, TJ; Dodd, SL; Neighbors, DM; Wilson, J, 2001) |
| "An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain." | 3.71 | Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001) |
| "The study examined the validity of oral fentanyl self-administration (FSA) as a measure of the chronic nociceptive pain that develops in rats with adjuvant arthritis independently of acute noxious challenges." | 3.71 | Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats. ( Alliaga, M; Attal, N; Bruins Slot, LA; Colpaert, FC; Koek, W; Tarayre, JP, 2001) |
| "This multicentre, observational study examined the efficacy of the therapeutic transdermal fentanyl system (TTS-fentanyl) in children requiring opioids for pain in life-threatening disease." | 3.71 | Transdermal fentanyl for pain relief in a paediatric palliative care population. ( Devine, T; Goldman, A; Hunt, A; Phillips, M, 2001) |
| "Oral morphine is the treatment first recommended for nociceptive pain insufficiently relieved by WHO level I and II analgesics." | 3.71 | [New Level III opioids of the World Health Organization]. ( Laval, G; Mallaret, M; Sang, B; Villard, ML, 2002) |
| "We describe two cases of unexpected perineal pain immediately after intravenous injection of fentanyl and dexamethasone (100 microg and 8 mg respectively) during induction of general anaesthesia." | 3.71 | Excruciating perineal pain after intravenous dexamethasone. ( Neff, SP; Stapelberg, F; Warmington, A, 2002) |
| "Continuous fentanyl infusion should be considered for the treatment of cancer pain in patients requiring high doses who become refractory to other opioids, when other opioids cause intolerable adverse effects, when patients have a true morphine allergy, or when high-dose requirements threaten to deplete existing stock of alternate opioids." | 3.70 | Continuous fentanyl infusion: use in severe cancer pain. ( Dunlap, DS; Lenz, KL, 1998) |
| "A transdermal fentanyl patch for the treatment of chronic cancer-related pain is available in four dosages (25, 50, 75, and 100 microg/hr)." | 3.70 | Factors influencing quality of life in cancer patients: the role of transdermal fentanyl in the management of pain. ( Payne, R, 1998) |
| " Our aim was to determine whether a novel breath-actuated, microprocessor-controlled metered dose oral inhaler (SmartMist, Aradigm Corporation) could deliver fentanyl in a way suitable for control of severe pain." | 3.70 | Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery. ( Eltherington, LG; Farr, SJ; Mather, LE; Rubsamen, RA; Ward, ME; Woodhouse, A, 1998) |
| "This study confirms that the addition of lumbar epidural fentanyl 100 micrograms to 15 mg of epidural bupivacaine provides good control of labour pain with no motor block and establishes that this combination preserves dorsal column sensory function." | 3.70 | Intact proprioception and control of labour pain during epidural analgesia. ( Abrahams, M; Breen, P; Gardiner, J; Higgins, P; Muttu, S; Whyte, P, 1999) |
| "In this experimental pain model, activation of peripheral mu or kappa opioid receptors can attenuate capsaicin-induced thermal hyperalgesia in rats." | 3.70 | Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. ( Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH, 2000) |
| "To evaluate the proportion of drug abuse related to opioid analgesics and the trends in medical use and abuse of 5 opioid analgesics used to treat severe pain: fentanyl, hydromorphone, meperidine, morphine, and oxycodone." | 3.70 | Trends in medical use and abuse of opioid analgesics. ( Dahl, JL; Gilson, AM; Joranson, DE; Ryan, KM, 2000) |
| " The current report details five children in whom a percutaneously placed lumbar intrathecal catheter was used: (i) to provide intraoperative surgical anaesthesia instead of general anaesthesia (ii); to deliver intrathecal fentanyl to provide postoperative analgesia (iii); to provide chronic pain control during the terminal stages of metastatic malignancy; (iv) to allow repeated doses of intrathecal chemotherapy; and (v) to allow CSF drainage and prevent CSF leakage following frontal encephalocele repair." | 3.70 | Applications of intrathecal catheters in children. ( Tobias, JD, 2000) |
| "The transdermal fentanyl patch is proving to be a safe, well tolerated and effective treatment modality in the control of cancer pain, but care has to be exercised when using this drug, especially at the time of initiation, as the consequences may be disastrous for the patient." | 3.70 | A pitfall to avoid when starting a patient on transdermal fentanyl. ( Chye, R; Low, JA, 2000) |
| "Epidural analgesia with local anesthetics administered alone or in combination with fentanyl effectively and safely treats the pain of sickle cell vaso-occlusive crisis unresponsive to conventional pain management and does so without causing sedation, respiratory depression, or significant limitation on ambulation." | 3.69 | Epidural analgesia in the management of severe vaso-occlusive sickle cell crisis. ( Billett, C; Casella, JF; Dover, G; Tobin, JR; Yaster, M, 1994) |
| " with formalin, behavioural correlates of the amount and pattern of Fos-like immunoreactivity (Fos-Ll) (molecular responses to pain) were studied to test if early phase treatment with 75% nitrous oxide or 2% halothane, or both, suppressed subsequent spinal sensitization." | 3.69 | Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin. ( Shieh, JY; Shyu, BC; Sun, WZ, 1996) |
| "Over an eight-month period, a convenience sample of consenting patients at an urban teaching hospital ED who required sedation for painful procedures were enrolled in a descriptive study of therapeutic propofol sedation." | 3.69 | The use of propofol for sedation in the emergency department. ( Mathias, S; Seaberg, DC; Swanson, ER, 1996) |
| "To study use of Duragesic (fentanyl transdermal system), the only transdermal opioid approved in Canada for treating chronic cancer pain in adults." | 3.69 | Fentanyl transdermal system. Pain management at home. ( Hays, H; Woodroffe, MA, 1997) |
| " administration of acetic acid produces abdominal contractions reflecting visceral pain, and gastrointestinal ileus characterized by inhibition of gastric emptying and small intestine transit." | 3.69 | Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. ( Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ, 1997) |
| "A 62-year-old man receiving subcutaneous fentanyl for the management of cancer pain developed generalized central excitation after an overdose of 5000 micrograms of fentanyl." | 3.69 | Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain. ( Bruera, E; Pereira, J, 1997) |
| "In a 32 years old patient with advanced gastric cancer epidural analgesia with local anaesthetic and morphine via a thoracic epidural catheter was required because of intractable pain and intolerable side effects of intravenous morphine." | 3.69 | [Conversion from peridural to transdermal opiate analgesia in abdominal tumor pain syndrome]. ( Fösel, T; Gaiser, H; Müller, R; Schuler, M, 1997) |
| "To report a case of high transdermal fentanyl dosage requirements in a patient with chronic cancer pain." | 3.68 | High transdermal fentanyl requirements in a patient with chronic cancer pain. ( Lehr, VT; Renaud, EA, 1993) |
| "These results suggest that steady-state serum concentrations are approached by the second dose of TTS(fentanyl) and that the kinetics are stable with repeated dosing." | 3.68 | Transdermal fentanyl for cancer pain. Repeated dose pharmacokinetics. ( Foley, KM; Gupta, SK; Inturrisi, CE; Lapin, J; Layman, M; Portenoy, RK; Southam, MA, 1993) |
| " A retrospective analysis of 79 ESWL procedures on 73 consecutive unselected patients was done in an attempt to determine the effectiveness of TENS in reducing the amount of intravenous fentanyl citrate and/or midazolam HCl needed to control pain and anxiety during the ESWL procedure." | 3.68 | The use of transcutaneous electrical nerve stimulation during the biliary lithotripsy procedure. ( Baumgartner, BR; Evans, GR; Fraser, NP; Jones, V; Nelson, RC; Peterson, J; Torres, WE, 1992) |
| "The author studied the use of intravenous Propofol for the relief of pain." | 3.68 | [Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl]. ( Croston, J; de Henriquez, L; de Jiménez, L; Espinosa, V, 1992) |
| "Five children with cancer pain were given continuous intrathecal morphine or fentanyl infusion associated with bupivacaine 0." | 3.68 | [Intrathecal morphine therapy in children with cancer]. ( Ganansia, MF; Lejus, C; Meignier, M; Testa, S, 1992) |
| "Diagnostic epidural blocks were performed on 27 chronic pain patients sequentially using saline, fentanyl, and lidocaine solution." | 3.67 | Diagnostic epidural opioid technique. ( Ellis, JS; Hoffman, J; Ramamurthy, S; Schoenfeld, LS; Walsh, NE, 1989) |
| "Perineal pain during the course of routine epidural analgesia with bupivacaine was treated with a 10-ml top-up of either bupivacaine 25 mg, fentanyl 100 micrograms or fentanyl 100 micrograms plus bupivacaine 10 mg, in 46 women in the first stage of labour." | 3.67 | Epidural fentanyl and perineal pain in labour. ( O'Sullivan, G; Reynolds, F, 1989) |
| "Five cancer patients experienced satisfactory pain relief for periods of 3-156 days using continuous transdermal delivery of the narcotic fentanyl." | 3.67 | Transdermal fentanyl for pain control in patients with cancer. ( Dothage, JA; Miser, AW; Miser, JS; Narang, PK; Sindelar, W; Young, RC, 1989) |
| "To investigate the selective role of intraspinal opioids on the perception and modulation of pain, seven subjects with chronic hip or back pain and one subject with C-6 quadriplegia received 25 micrograms of intrathecal fentanyl." | 3.67 | Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain. ( Chabal, C; Jacobson, L; Little, J, 1989) |
| "1 micrograms/kg fentanyl in low back pain patients reduced both sensory intensity and unpleasantness visual analogue scale (VAS) responses to experimental pain evoked by graded 5-sec nociceptive temperature stimuli (45-51 degrees C) as well as VAS-sensory and VAS-affective responses to clinical pain." | 3.67 | A simultaneous comparison of fentanyl's analgesic effects on experimental and clinical pain. ( Harkins, SW; Price, C; Price, DD; Rafii, A, 1986) |
| "The effect of thyrotropin releasing hormone (TRH) on modified neuroleptanesthesia with fentanyl-flunitrazepam was investigated in an open pilot study of 15 neurosurgical patients." | 3.67 | Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man. ( Dangelmaier, R; Glöser, A; Hempel, V; Lenz, G, 1986) |
| "The effects of a continuous epidural administration of fentanyl on pain and on ventilation were studied in eight patients scheduled for orthopedic surgery of the knee." | 3.67 | Ventilatory effects of continuous epidural infusion of fentanyl. ( Brichant, JF; Chauvin, M; Clergue, F; Levron, JC; Renaud, B; Viars, P, 1988) |
| " This work was performed in order to evaluate the dose-response relationship, time course, and naloxone reversibility of fentanyl suppression of neurons that are involved with the transmission of information about pain." | 3.66 | Dose-response suppression of noxiously evoked activity of WDR neurons by spinally administered fentanyl. ( Collins, JG; Kitahata, LM; Matsumoto, M; Suzukawa, M; Yuge, O, 1983) |
| " For unanesthetized tubes the mean pain rating depended on the dose of diazepam and fentanyl given to the patient (p less than ." | 3.65 | Laparoscopic tubal clip sterilization under local anesthesia. ( Edelman, DA; Fishburne, JI; Hulka, JF; Mercer, JP; Omran, KF, 1974) |
| "Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths." | 3.30 | Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. ( Belval, LN; Cramer, MN; Crandall, CG; Foster, J; Hendrix, JM; Hinojosa-Laborde, C; Huang, M; Moralez, G; Watso, JC, 2023) |
| "The pre-treatment pain severity of the groups was similar (p = 0." | 3.30 | The efficacy of intradermal sterile water application in severe renal colic: a randomised clinical trial. ( Ak, R; Aykanat, MC; Cimilli Öztürk, T; Kılıç, M; Ustaalioğlu, İ, 2023) |
| "Fentanyl was the opioid used in the OCA group." | 3.11 | A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial. ( Campos-Pérez, W; Cuevas, JHM; González-Landeros, D; Martínez-López, E; Pérez-Robles, M; Pérez-Vargas, L; Ramírez-Plascencia, L; Rivera-Valdés, JJ; Sánchez-Muñoz, P, 2022) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 3.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| " The efficacy and safety of the sedations including sedation time intervals, nausea score, vomiting episodes, pain score, adverse effects, and parent's satisfaction were evaluated." | 3.11 | The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial. ( Lertvivatpong, N; Malaithong, W; Monsereenusorn, C; Photia, A; Rujkijyanont, P; Traivaree, C, 2022) |
| "Using Department of Defense Trauma Registry data for the Afghanistan conflict from 2005 to 2018, we examined 2,402 records of prehospital analgesia administration to assess temporal trends in medication choice and proportions receiving analgesia, including subanalysis of a cohort screened for an indication with minimal contraindication for analgesia." | 3.01 | Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan. ( Burgess, M; Hinojosa-Laborde, C; Hudson, IL; Newberry, RK; Ryan, KL; Schauer, SG; Staudt, AM; VanFosson, CA, 2023) |
| "Remifentanil PCA was superior to fentanyl PCA for analgesia at an early time point, and it increased the incidence of oxygen desaturation relative to other strategies of delivering epidural solution." | 3.01 | Comparison of different delivery modalities of epidural analgesia and intravenous analgesia in labour: a systematic review and network meta-analysis. ( Desai, N; Nzekwu, B; Onwochei, D; Owolabi, A; Wydall, S; Zolger, D, 2023) |
| "Fentanyl was not associated with mortality risk compared to the control (risk ratio: 0." | 3.01 | Effect of Fentanyl for Preterm Infants on Mechanical Ventilation: A Systematic Review and Meta-Analysis. ( Haga, M; Kajikawa, D; Kuratsuji, G; Namba, F; Ota, E; Seki-Nagasawa, J; Shokraneh, F; Sudo, Y; Yamaji, N, 2023) |
| "Propofol is a commonly used sedative, frequently combined with an opioid or low-dose ketamine as an analgesic." | 3.01 | Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review. ( De Vries, LJ; Lameijer, H; Van Roon, EN; Veeger, NJGM, 2023) |
| "An observer masked to the treatment assessed pain, pre- and postoperatively, with the Glasgow (GCPS), the Colorado (CPS) pain scales and a Visual Analogue Scale (VAS); additionally, the mechanical thresholds (MT) were measured with the Electronic von Frey Anaesthesiometer (EVF) at four points located near the herniated disc." | 2.94 | Use of acupuncture as adjuvant analgesic technique in dogs undergoing thoracolumbar hemilaminectomy. ( Adami, C; Machin, H; Taylor-Brown, F, 2020) |
| " (4) Compared with control group with the same sedative, the duration of mechanical ventilation, extubation time, length of ICU stay were significantly shortened, and the dosage of sedative drugs used was reduced in study group (all P < 0." | 2.82 | [Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit]. ( Dong, C; Feng, F; Li, J; Qi, Y; Song, R; Yang, J; Yang, Z; Zhang, H, 2016) |
| "And propofol was used for rescue." | 2.79 | [Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation]. ( Huang, F; Jin, J; Kong, J; Liu, S; Wang, J; Xu, H; Yang, X, 2014) |
| "2201 cancer pain patients were included." | 2.77 | Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS). ( Fayers, P; Fladvad, T; Kaasa, S; Klepstad, P; Skorpen, F, 2012) |
| " There was no significant difference in the incidence of adverse effects between the two drugs." | 2.77 | The effectiveness and adverse events of morphine versus fentanyl on a physician-staffed helicopter. ( Cudnik, M; Emerman, CL; Pakiela, J; Smith, DA; Smith, MD; Wang, Y, 2012) |
| "Severe pain is defined as rated seven or greater on a 0 to 10 age-appropriate numeric pain scale or equivalent." | 2.77 | Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial. ( an Fhailí, S; Barrett, MJ; Cronin, J; Grant, T; Hayden, J; McCoy, S; McMahon, C; Murphy, A; O'Sullivan, R; Wakai, A; Walsh, S, 2012) |
| " We aimed to determine the analgesic and adverse effects of intrathecal neostigmine combined with hyperbaric bupivacaine and fentanyl." | 2.77 | Analgesic effect of intrathecal neostigmine combined with bupivacaine and fentanyl. ( Akinwale, MO; Akinyemi, OA; Sotunmbi, PT, 2012) |
| "Patients with chronic cancer pain were randomly assigned to the conversion from continuous intravenous infusion to transdermal fentanyl using two-step taper of the continuous intravenous infusion in 12 h (12-h method) or the conversion in 6 h (6-h method)." | 2.76 | Six- versus 12-h conversion method from intravenous to transdermal fentanyl in chronic cancer pain: a randomized study. ( Hayashi, K; Kamata, M; Kojima, H; Kozai, M; Nomura, M; Sawada, S, 2011) |
| "Of 139 recruited patients, 69% identified an effective dose of sublingual fentanyl ODT (a dosage that successfully treated all episodes of BTcP over two consecutive days) and entered the maintenance phase, during which they were treated for a median of 149." | 2.76 | Long-term effectiveness and tolerability of sublingual fentanyl orally disintegrating tablet for the treatment of breakthrough cancer pain. ( Derrick, R; Dumble, S; Hassman, D; Howell, J; Nalamachu, S; Wallace, MS, 2011) |
| " Adverse events were also recorded." | 2.76 | The efficacy and safety of fentanyl buccal tablet compared with immediate-release oxycodone for the management of breakthrough pain in opioid-tolerant patients with chronic pain. ( Ashburn, MA; Messina, J; Slevin, KA; Xie, F, 2011) |
| " Adverse events were recorded throughout." | 2.76 | Sublingual fentanyl orally disintegrating tablet in daily practice: efficacy, safety and tolerability in patients with breakthrough cancer pain. ( Müller-Schwefe, GH; Überall, MA, 2011) |
| "Endovascular abdominal aortic aneurysm (AAA) repair was performed with local anaesthesia and intravenous analgesia." | 2.76 | Analgesia and endocrine surgical stress: effect of two analgesia protocols on cortisol and prolactin levels during abdominal aortic aneurysm endovascular repair. ( Baraldi, E; Barbieri, A; Coppi, G; D'Amico, R; Ferrari, A; Genazzani, A; Giuliani, E, 2011) |
| "Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia." | 2.75 | Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010) |
| "Open-label, randomized, four-period, Latin-square crossover pharmacokinetic study." | 2.75 | Single-dose pharmacokinetics of fentanyl buccal soluble film. ( Finn, AL; Gever, LN; Tagarro, I; Vasisht, N, 2010) |
| "During maintenance treatment, 70 of 646 patients (11%) discontinued because of adverse events (AEs), 69 of 646 (11%) because of withdrawn consent, and 57 of 646 (9%) because of noncompliance." | 2.75 | Long-term safety and tolerability of fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic pain: an 18-month study. ( Fine, PG; Messina, J; Rathmell, J; Xie, F, 2010) |
| " The dosage used was 50% of that indicated in equipotency conversion tables." | 2.74 | Opioids switching with transdermal systems in chronic cancer pain. ( Aurilio, C; Barbarisi, M; Grella, E; Pace, MC; Passavanti, MB; Pota, V; Sansone, P, 2009) |
| "Fentanyl is an opioid with high lipid solubility, suitable for intravenous, spinal, transmucosal and transdermal administration." | 2.74 | Transdermal fentanyl in cachectic cancer patients. ( Gergov, M; Haakana, S; Heiskanen, T; Kalso, E; Mätzke, S; Vuori, E, 2009) |
| "Breakthrough cancer pain (BTcP) represents an important clinical challenge in the care of patients with cancer." | 2.74 | Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain. ( Bartkowiak, AJ; Derrick, R; Hassman, D; Hayes, TG; Howell, J; Nalamachu, S; Rauck, RL; Reyes, E; Tark, M, 2009) |
| " Any adverse events were recorded; four tolerability endpoints, constipation, nausea, daytime drowsiness, and sleeping disturbances, were assessed daily." | 2.73 | A randomized, open, parallel group, multicenter trial to investigate analgesic efficacy and safety of a new transdermal fentanyl patch compared to standard opioid treatment in cancer pain. ( Heiskanen, T; Hoerauf, KH; Jensen, NH; Krenn, H; Kress, HG; Lundorff, L; Nolte, T; Petersen, R; Rosland, JH; Sabatowski, R; Saedder, EA; Von der Laage, D, 2008) |
| "To determine whether healthy and traumatized dogs receiving a constant rate infusion (CRI) of either morphine or fentanyl have decreased urine production." | 2.73 | Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs. ( Anderson, MK; Day, TK, 2008) |
| "2% of patients experienced adverse events that were either probably related or very likely to be related to the study drug." | 2.73 | Safety and efficacy of transdermal fentanyl in patients with cancer pain: phase IV, Turkish oncology group trial. ( Aliustaoğlu, M; Altinbaş, M; Altundağ, K; Atahan, L; Cooper, R; Demirkan, B; Kömürcü, S; Manavoğlu, O; Ozdemir, F; Ozkök, S; Pak, Y; Sarihan, S; Turhal, S; Turna, HS; Yavuz, AA; Yaylaci, M, 2007) |
| "In episodes treated with IV-MO, pain intensity decreased from a mean of 6." | 2.73 | Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain. ( Casuccio, A; Ferrera, P; Intravaia, G; Mangione, S; Mercadante, S; Villari, P, 2007) |
| " Pain intensity (PI) (rated on an 11-point pain scale, from 0 = no pain to 10 = worst pain) and other outcomes were assessed before dosing and for 2 hours after dosing." | 2.73 | Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study. ( Hale, M; Messina, J; Simpson, DM; Xie, F, 2007) |
| "Remifentanil prevented increase in MAP and HR while alfentanil and fentanyl were ineffective in this purpose (p < 0." | 2.73 | Analgesia for retrobulbar block--comparison of remifentanil, alfentanil and fentanyl. ( Asadipour, E; Maghsoudi, B; Talebnejad, MR, 2007) |
| "Although common treatments for osteoarthritis (OA) pain, such as nonsteroidal antiinflammatory drugs (NSAIDs), simple analgesics, and weak opioids, provide relief in some cases, they fail to control pain or are poorly tolerated in many cases." | 2.72 | Transdermal fentanyl for improvement of pain and functioning in osteoarthritis: a randomized, placebo-controlled trial. ( Langford, R; McKenna, F; Ratcliffe, S; Richarz, U; Vojtassák, J, 2006) |
| "Buprenorphine causes limited respiratory depression with a ceiling effect at higher doses, while fentanyl causes dose-dependent respiratory depression with apnoea at high dose levels." | 2.72 | Opioid-induced respiratory effects: new data on buprenorphine. ( Dahan, A, 2006) |
| "The primary objective of this study was to compare the relative bioavailability of FEBT 1,080 microg with that of oral transmucosal fentanyl citrate (OTFC) 1,600 microg, and the secondary objective was to assess the dose proportionality of FEBT 270 to 1,300 microg in healthy adult volunteers." | 2.72 | Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1,080 pg versus oral transmucosal fentanyl citrate 1,600 pg and dose proportionality of FEBT 270 to 1,300 microg: a single-dose, randomized, open-label, three-period study in healt ( Darwish, M; Kirby, M; Tempero, K; Thompson, J, 2006) |
| " The magnitude of analgesia in the cold pressor model showed some correlation with TDF dosage and comparable effects for the full agonist fentanyl and the partial agonist buprenorphine." | 2.72 | Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. ( Gasser, UE; Koltzenburg, M; Pokorny, R; Richarz, U, 2006) |
| " The objective of this study was to further evaluate the pharmacokinetic effect of local heat administration on fentanyl drug delivery through the transdermal fentanyl patch delivery system in volunteers." | 2.71 | The pharmacokinetics of transdermal fentanyl delivered with and without controlled heat. ( Ashburn, MA; Basta, SV; Love, G; Ogden, LL; Zhang, J, 2003) |
| "Patients receiving propofol reached full recovery sooner (16." | 2.71 | Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. ( Chadalawada, V; Hansen, JJ; Liangpunsakul, S; Mendel, AM; Overley, CA; Rex, DK; Strahl, E; Symms, MR; Ulmer, BJ, 2003) |
| "Fentanyl is a synthetic opioid that can be delivered through a transdermal therapeutic system (TTS)." | 2.71 | Transdermal fentanyl in HSCT patients: an open trial using transdermal fentanyl for the treatment of oral mucositis pain. ( Carrassi, A; Deliliers, GL; Demarosi, F; Lodi, G; Sardella, A; Soligo, D; Volpe, AD, 2004) |
| " Fourteen patients receiving strong opioids who had increased their dosage more than 100% in the last week unsuccessfully were randomly chosen to add a second opioid to the first using an initial equivalent dosage of 20% of the previous therapy." | 2.71 | Addition of a second opioid may improve opioid response in cancer pain: preliminary data. ( Casuccio, A; Ferrera, P; Mercadante, S; Villari, P, 2004) |
| "Remifentanil is a short acting, potent synthetic opioid that does not accumulate after infusion or repeated bolus doses." | 2.71 | Remifentanil vs fentanyl/morphine for pain and stress control during pediatric cardiac surgery. ( Arana, A; Bell, G; Dickson, U; Marshall, C; Morton, N; Robinson, D, 2004) |
| " In this respect, further studies related to dosage of intrathecal levobupivacaine in obstetric labor analgesia will be beneficial in substantiating this point." | 2.71 | Intrathecal labor analgesia using levobupivacaine 2.5 mg with fentanyl 25 microg--would half the dose suffice? ( Chan, SY; Chiu, JW, 2004) |
| " Pharmacokinetic parameters were calculated by noncompartment analysis." | 2.71 | Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain. ( Bredenberg, S; Hedner, T; Holmberg, M; Lennernäs, B; Lennernäs, H; Nyström, C, 2005) |
| "Pain was assessed using a 10-point verbal analogue scale and <3 was considered adequate analgesia." | 2.71 | Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy. ( Acuña, D; Cortínez, LI; Dagnino, JA; De la Fuente, R; Muñoz, HR, 2005) |
| "If fentanyl was given with the lidocaine in the para-cervical block, it potentially could improve pain control while decreasing side effects and avoiding i." | 2.71 | Intra-cervical versus i.v. fentanyl for abortion. ( Savoy, E; Trouton, KJ; Wiebe, ER, 2005) |
| " In groups 6 and 7, additional fentanyl doses were lower than in the other groups, but only in group 7 was the total fentanyl dosage low." | 2.71 | Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy. ( Basar, H; Basar, MM; Batislam, E; Ozcan, S; Tuglu, D; Yilmaz, E, 2005) |
| " Large patient-to-patient variations in pharmacokinetic parameters occurred, although intraindividual variability was limited." | 2.71 | Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients. ( Bressolle, F; Caumette, L; Culine, S; Garcia, F; Pinguet, F; Poujol, S; Solassol, I, 2005) |
| " In the 16 who received fentanyl for > or =3 months until death, the median dose was unchanged (100 microg/h) 3 months before death and at death; 8/16 required no dosage change." | 2.70 | Long-term observations of patients receiving transdermal fentanyl after a randomized trial. ( Ahmedzai, SH; Brooks, D; Davis, C; Nugent, M, 2001) |
| "We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease." | 2.70 | Transdermal fentanyl therapy for pains in children with infantile neuronal ceroid lipofuscinosis. ( Heiskala, HJ; Mannerkoski, MK; Pouttu, JA; Santavuori, PR, 2001) |
| "The treatment of cancer pain with transdermal fentanyl can be performed as a long-term therapy and result in good pain relief." | 2.69 | Long-term treatment of cancer pain with transdermal fentanyl. ( Donner, B; Raber, M; Strumpf, M; Zenz, M, 1998) |
| "TTS fentanyl was titrated to pain relief, and patients were followed up for as long as 3 months." | 2.69 | A clinical evaluation of transdermal therapeutic system fentanyl for the treatment of cancer pain. ( Hays, H; Moulin, DE; Sloan, PA, 1998) |
| "To treat cancer pain, physicians often decide to jump directly from step 1 of the World Health Organization (WHO) analgesic ladder to step 3." | 2.69 | Transdermal fentanyl in opioid-naive cancer pain patients: an open trial using transdermal fentanyl for the treatment of chronic cancer pain in opioid-naive patients and a group using codeine. ( Mattern, C; Uitendaal, MP; Vielvoye-Kerkmeer, AP, 2000) |
| "Fentanyl has no effect on the perceived intensity or unpleasantness of vibratory stimulation, which continues to activate contralateral S1." | 2.69 | Selective opiate modulation of nociceptive processing in the human brain. ( Casey, KL; Jone, C; Minoshima, S; Morrow, TJ; Raz, J; Svensson, P, 2000) |
| "Morphine was started i." | 2.69 | Comparison of fentanyl and droperidol mixture (neuroleptanalgesia II) with morphine on clinical outcomes in unstable angina patients. ( Bronisz, M; Burduk, P; Guzik, P; Jazdon, M; Jordan, MR; Piechocka, M; Rozek, A, 2000) |
| "TTS fentanyl was shown to be an effective, safe and simple method for long-term pain relief in cancer patients and presents an interesting novel option in the treatment of cancer pain." | 2.68 | Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia. ( Lehmann, KA; Zech, DF, 1995) |
| "When fentanyl was given, either more doses were necessary (3." | 2.67 | Double-blind comparison of intravenous butorphanol (Stadol) and fentanyl (Sublimaze) for analgesia during labor. ( Atkinson, BD; Christensen, HD; Rayburn, WF; Truitt, LJ; Turnbull, GL; Wlodaver, A, 1994) |
| "Midazolam was found to be the drug of preference for the majority of patients." | 2.67 | Midazolam versus fentanyl as premedication for painful procedures in children with cancer. ( Conner, K; Dickson, N; Luzins, J; McGorray, S; Reilly, K; Sandler, ES; Weyman, C, 1992) |
| "Alfentanil was used as an adjuvant to midazolam for analgesia in thirty outpatients undergoing colonoscopy." | 2.67 | Pain relief for outpatient colonoscopy: a comparison of alfentanil with fentanyl. ( Holloway, AM; Logan, DA, 1990) |
| "Fentanyl has been FDA approval as an analgesic since 1968 and multiple different fentanyl preparations have been developed over the years." | 2.66 | Reasons to avoid fentanyl. ( Behm, B; Davis, MP, 2020) |
| "This shift in temperature reached a peak effect 11 min after fentanyl administration." | 2.66 | A multiple random staircase method of psychophysical pain assessment. ( Dubner, R; Gracely, RH; Lota, L; Walter, DJ, 1988) |
| "No pain was experienced by patients receiving thiopentone." | 2.65 | Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia. ( Aromaa, U; Korttila, K; Tammisto, T, 1979) |
| "Fentanyl was shown to be the most prescribed strong opioid in outpatient settings in Germany, despite not being the first-line choice for chronic pain conditions." | 2.61 | Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence. ( Neicun, J; Roman-Urrestarazu, A; Rosner, B; Yang, JC, 2019) |
| " This article illustrates these challenges using a post-authorization safety study (PASS) to assess adverse events (AEs) experienced with fentanyl buccal tablet (FBT) over 3 months of treatment." | 2.58 | Challenges of post-authorization safety studies: Lessons learned and results of a French study of fentanyl buccal tablet. ( Bartov, N; Bidollari, I; Gavrielov-Yusim, N; Kaplan, S, 2018) |
| " There are advantages and disadvantages in using these 2 opioids which are discussed, and potential dosing strategies are outlined." | 2.58 | What Parenteral Opioids to Use in Face of Shortages of Morphine, Hydromorphone, and Fentanyl. ( Behm, B; Davis, MP; Fernandez, C; McPherson, ML; Mehta, Z, 2018) |
| "Mechanistic approaches and multimodal analgesic techniques have been clearly demonstrated to be the most effective pain management strategy to improve outcomes." | 2.55 | Analgesia in the surgical intensive care unit. ( Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S, 2017) |
| "His pain was scored as a five on a six-point visual analog scale, and it persisted despite routine supportive therapy." | 2.50 | [A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl]. ( Anzai, S; Hashimoto, Y; Nagasawa, K; Suzuki, T, 2014) |
| "Fentanyl is a potent mu opioid receptor agonist that was discovered to identify an improved human health analgesic over morphine, an opioid frequently associated with histamine-release, bradycardia, hyper- or hypotension, and prolonged postoperative respiratory depression." | 2.48 | The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs. ( Clark, TP; Kukanich, B, 2012) |
| " The purposes of this analysis were to identify and review published data describing the pharmacokinetic properties of rapid-onset fentanyl formulations and to evaluate these properties in view of the temporal dynamic characteristics of BTP in order to help guide medical practice." | 2.48 | A review of the pharmacokinetic profile of transmucosal fentanyl formulations. ( Amores, X; Darwish, M; Moore, N; Schneid, H, 2012) |
| "The pain experienced by cancer patients can be managed in 70-90% of cases by the World Health Organisation protocol for cancer pain." | 2.47 | [Solutions for the clinical problems of analgesics for cancer pain treatment in Japan]. ( Kokubun, H; Matoba, M; Yago, K; Yamada, Y, 2011) |
| "Despite advances in the management of cancer pain, through the application of modern, evidence-based, multimodality management and the availability of new treatment options, recent European surveys have indicated that the diagnosis and treatment of BTcP is still suboptimal." | 2.47 | Integrated strategies for the successful management of breakthrough cancer pain. ( Dickman, A, 2011) |
| "Methadone also has a long elimination half-life (19 [SD 14] hours) and NMDA receptor activity although dose administration is complicated by highly variable morphine equianalgesic equivalence (1 : 2." | 2.45 | Pediatric palliative care: use of opioids for the management of pain. ( Anderson, BJ; Craig, F; Michel, E; Zernikow, B, 2009) |
| "The treatment of BTP in cancer patients receiving opioids is principally based on the use of opioids, preferentially with a short onset." | 2.45 | Treatment strategies for cancer patients with breakthrough pain. ( Casuccio, A; Fulfaro, F; Mercadante, S, 2009) |
| "Fentanyl is a lipophilic, short-acting, synthetic opioid with a piperidine chemical structure." | 2.45 | The role of fentanyl in cancer-related pain. ( Prommer, E, 2009) |
| "Up to 80% of people with cancer experience pain at some time during their illness, and most will need opioid analgesics." | 2.44 | Opioids in people with cancer-related pain. ( Quigley, C, 2008) |
| "Breakthrough pain is a prevalent and serious problem in patients with cancer." | 2.44 | A titration strategy is needed to manage breakthrough cancer pain effectively: observations from data pooled from three clinical trials. ( Farrar, JT; Fisher, K; Hagen, NA; Victorino, C, 2007) |
| "Fentanyl TTS is a promising option for chronic pain control in children." | 2.44 | Transdermal fentanyl in childhood and adolescence: a comprehensive literature review. ( Anderson, B; Michel, E; Zernikow, B, 2007) |
| " FBT utilizes OraVescent technology to improve bioavailability and speed of drug delivery." | 2.44 | Fentanyl buccal tablet: faster rescue analgesia for breakthrough pain? ( Hanna, M; Lecybyl, R, 2007) |
| "Pain is experienced by most cancer patients and represents an important issue in the clinical setting." | 2.44 | Oral transmucosal fentanyl citrate in cancer pain management: a practical application of nanotechnology. ( Mystakidou, K; Tsiatas, M; Tsilika, E; Vlahos, L, 2007) |
| "As a result of improved survival in cancer and the transfer of care from hospital to primary care, community nurses are taking increasing responsibility for the management of patients at all stages of the disease." | 2.44 | Actiq: an effective oral treatment for cancer-related breakthrough pain. ( Laverty, D, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | 2.44 | The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| "The fentanyl buccal tablet is a new sugar-free, easily-administered formulation that uses an effervescent drug delivery system to enhance the rate and extent of fentanyl absorption across the buccal mucosa." | 2.44 | Fentanyl buccal tablet: rapid relief from breakthrough pain. ( Taylor, DR, 2007) |
| "Studies of populations with chronic cancer pain have shown a high prevalence of breakthrough pain (BTP), defined as transitory, severe flares of pain that occur on a background of otherwise controlled, persistent pain." | 2.44 | Fentanyl buccal tablet. ( Darwish, M; Fine, PG; Messina, J, 2008) |
| "Pain in older cancer patients is a common event, and many times it is undertreated." | 2.44 | Management of pain in the older person with cancer. Part 2: treatment options. ( Bruera, E; Delgado-Guay, MO, 2008) |
| "Breakthrough pain is a common problem in patients with cancer, and is associated with significant morbidity among this group of patients." | 2.43 | Cancer-related breakthrough pain. ( Davies, AN, 2006) |
| "Persistent pain is present to some degree throughout the day and primarily is controlled with around-the-clock medication." | 2.42 | Managing breakthrough pain: a clinical review with three case studies using oral transmucosal fentanyl citrate. ( Palos, G; Rhiner, M; Termini, M, 2004) |
| " Regular pain assessments combined with appropriate analgesic administration at regular dosing intervals, adjunctive drug therapy for control of adverse effects and associated symptoms, and nonpharmacological interventions are recommended." | 2.42 | Cancer pain management in children. ( Mercadante, S, 2004) |
| "Breakthrough pain affects at least two-thirds of cancer patients at some point during their illness (Portenoy and Hagen, 1990; di Palma et al, 2000)." | 2.41 | The role of oral transmucosal fetanyl citrate in the management of breakthrough cancer pain. ( Rees, E, 2002) |
| " This review analyses the pharmacokinetic properties of transdermal opioid administration in the context of clinical experience, with a focus on fentanyl." | 2.41 | Clinical pharmacokinetics of transdermal opioids: focus on transdermal fentanyl. ( Grond, S; Lehmann, KA; Radbruch, L, 2000) |
| " However, clinicians should realize that the manufacturer's recommendations for equianalgesic dosing of transdermal fentanyl may result in initial doses that are too low in some patients, and in a titration period that is too long." | 2.41 | An alternative algorithm for dosing transdermal fentanyl for cancer-related pain. ( Breitbart, W; Chandler, S; Eagel, B; Ellison, N; Enck, RE; Lefkowitz, M; Payne, R, 2000) |
| "Societal fears of opioid addiction and lack of advocacy are also causal factors in the under-treatment of pediatric pain." | 2.41 | Pain management in the critically ill child. ( Nichols, DG; Yaster, M, 2001) |
| " The dosing interval for these systems is generally 3 days." | 2.41 | Treatment of cancer pain with transdermal fentanyl. ( Gourlay, GK, 2001) |
| "Fentanyl is a synthetic opioid with short-acting analgesic activity after intravenous or subcutaneous administration." | 2.40 | Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control. ( Benfield, P; Jeal, W, 1997) |
| "Tramadol is a centrally acting analgesic drug; it has an agonist effect on mu 1 receptors of opioids and acts also by inhibiting the re-uptake of noradrenaline and serotonine which activates descending monoaminergic inhibitory pathways." | 2.40 | [Treatment of pain in oncology]. ( De Conno, F; Polastri, D, 1997) |
| "Pain is the most feared symptom for patients diagnosed with cancer." | 2.40 | Current strategies for pain control. ( Ahmedzai, S, 1997) |
| "The high prevalence of pain in cancer patients has been appreciated for a long time." | 2.40 | Practice guidelines for cancer pain therapy. Issues pertinent to the revision of national guidelines. ( Payne, R, 1998) |
| "When pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them, treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route should be considered." | 2.40 | Opioid rotation for cancer pain: rationale and clinical aspects. ( Mercadante, S, 1999) |
| "Alfentanil may cause less intense respiratory depression than equianalgesic doses of fentanyl." | 2.37 | Alfentanil in anesthesia and analgesia. ( Reitz, JA, 1986) |
| "Uterine fibroid embolization (UFE) procedures performed from 2013 to 2019 were reviewed." | 1.91 | Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols. ( Brahler, T; Hastings, G; Howles-Banerji, G; Kotton, M; Price, A; Singer, D; Wrenn, SJ, 2023) |
| "Pain is one of the major prehospital symptoms in trauma patients and requires prompt management." | 1.91 | Oral transmucosal fentanyl citrate analgesia in prehospital trauma care: an observational cohort study. ( Albrecht, R; Fischer, H; Grünenfelder, A; Hossfeld, B; Pietsch, U; Rüst, CA; Wenzel, V, 2023) |
| "Inhibition of these neurons alleviates hyperalgesia in male OIH rats but exerts an opposite effect in male control rats." | 1.91 | HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats. ( Gan, S; Li, CH; Luo, F; Wang, X; Zhang, Z; Zhu, P, 2023) |
| "Pain was measured as the probability of CPOT scores of ≥ 3, and subsequently adjusted based on each patient's baseline." | 1.91 | Continuous visualization and validation of pain in critically ill patients using artificial intelligence: a retrospective observational study. ( Kobayashi, N; Murakami, H; Watanabe, K; Yamauchi, M, 2023) |
| "Opioid-induced hyperalgesia (OIH) is a problem associated with prolonged use of opioids in chronic pain management, and its effective treatment has been hampered by lack of mechanistic evidence." | 1.72 | Inhibition of Oligodendrocyte Apoptosis in the Prelimbic Medial Prefrontal Cortex Prevents Fentanyl-induced Hyperalgesia in Rats. ( Cui, LL; Gan, SF; Li, CH; Luo, F; Wang, XX; Xiao, J; Zhang, ZR, 2022) |
| "There is an urgent need for development of drugs that are able to reverse the adverse effects of opioids on breathing and arterial blood-gas (ABG) chemistry while preserving opioid analgesia." | 1.72 | L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry. ( Baby, SM; Bates, JN; Gaston, B; Getsy, PM; Hsieh, YH; Lewis, SJ; Lewis, THJ; May, WJ, 2022) |
| "Complex regional pain syndrome is a chronic pain condition characterized by autonomic dysfunction, changes in sympathetic and vasomotor activity, and sensory and motor changes." | 1.72 | Atypical dermatologic manifestations in complex regional pain syndrome: a case report. ( Abcejo, AS; Langford, B; Pittelkow, TP, 2022) |
| "Its goal was to see how a transdermal fentanyl patch combined with accelerated recovery after surgery (ERAS) affected the treatment efficacy and analgesic effect of liver cancer, as well as to help patients with liver cancer choose the right analgesic treatment and nursing mode." | 1.72 | Effect of Transdermal Fentanyl Patch Combined with Enhanced Recovery after Surgery on the Curative Effect and Analgesic Effect of Liver Cancer. ( Fang, S; Lu, G; Xiao, H; Zhu, H, 2022) |
| "Fentanyl was introduced in 2013, and by 2019 was given to 39% of patients." | 1.72 | Trends in prehospital pain management: two decades of point-of-injury care. ( Avital, G; Bader, T; Benov, A; Chen, J; Fridrich, L; Gelikas, S; Glassberg, E; Nadler, R; Nakar, H; Sorkin, A; Tsur, AM, 2022) |
| " Data obtained from the electronic medical records included primary outcomes (visual analog scale [VAS] scores and anesthesia satisfaction rate) and secondary outcomes, including vital signs such as heart rate (HR), mean arterial pressure (MAP), total dosage of fentanyl, operation time, X-ray exposure time, Oswestry Disability Index (ODI) scores, and complications." | 1.72 | Analgesic effect of epidural anesthesia via the intervertebral foramen approach in percutaneous transforaminal endoscopic discectomy: a retrospective study. ( Cai, Z; Kang, J; Liu, Y; Nie, C; Wang, X; Zhang, J; Zhou, H, 2022) |
| "In contrast, withdrawal associated thermal hyperalgesia was found only in mice." | 1.62 | Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021) |
| "Opioid-induced constipation is the most prevalent adverse effect of opioid drugs." | 1.62 | Pharmacological characterization of naloxegol: In vitro and in vivo studies. ( Calò, G; Costanzini, A; De Giorgio, R; Malfacini, D; Neto, JA; Ruzza, C; Sternini, C; Sturaro, C, 2021) |
| "To assess sedation medication dosage differences between patients with and without opioid use disorder at the time of surgical abortion." | 1.62 | Pain medication requirements in patients with opioid use disorder at the time of surgical abortion: An exploratory study. ( Ramanadhan, S; Srikanth, P; White, KO; Woodhams, E, 2021) |
| " Opioid dosing remains challenging in burn patients, particularly in children, due to the immense variability in efficacy between patients." | 1.56 | Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients. ( Grimsrud, KN; Lima, KM; Palmieri, TL; Tran, NK, 2020) |
| "Cancer pain was observed in 131 of 160 patients with advanced cancer living at home." | 1.56 | [Analysis of Symptoms Relieved in Addition to Pain after Administration of Oxycodone or Morphine to Patients with Advanced Cancer Living at Home]. ( Watanabe, K, 2020) |
| " The purpose of this study is to identify the proportion of new FTS users who had evidence of prior opioid tolerance, by dosage strength, in FDA's Sentinel System." | 1.51 | Assessment of prior opioid tolerance among new users of fentanyl transdermal system in FDA's Sentinel System. ( Cocoros, NM; Ju, J; Kornegay, C; Larochelle, MR; Petrone, AB; Popovic, J; Racoosin, JA, 2019) |
| "Fentanyl has a low molecular weight and is lipophilic making it suitable for transdermal administration." | 1.51 | Unusual case of transdermal fentanyl in cachexia. ( Harrison, S; Kay, S; Lam, D; Pickard, J, 2019) |
| " Surprisingly, respiratory depression, constipation, and opioid withdrawal signs are unchanged or exacerbated, indicating that β-arrestin recruitment does not contribute to the severity of opioid side effects and, hence, predicting that G-protein-biased µ-agonists are still likely to elicit severe adverse effects." | 1.51 | Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects. ( Bailey, A; Bateman, JT; Christie, MJ; Kliewer, A; Levitt, ES; Schmiedel, F; Schulz, S; Sianati, S; Williams, JT, 2019) |
| "Fentanyl was the most common administered analgesic in the trauma subgroup, but significantly less common used by surgeons (p = 0." | 1.51 | Differences in pain treatment between surgeons and anaesthesiologists in a physician staffed prehospital emergency medical service: a retrospective cohort analysis. ( Blobner, M; Hofberger, C; Kanz, KG; Kappler, FP; Sattler, J; Schaller, SJ; Schneider, G; Wagner, R, 2019) |
| "Morphine was associated with a minimal incremental cost-effectiveness ratio of USD 135 per additional case of successful pain relief over fentanyl." | 1.51 | Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting. ( AbouNahia, F; Abushanab, D; Al-Badriyeh, D; Alsoukhni, O, 2019) |
| "Centipede bites are a constant risk throughout tropical regions and have the rare potential for systemic side effects." | 1.51 | Challenges of Remote Medical Care in South Sudan: Centipede Bites. ( Dickson, N; Moles, I; Pallett, SJC, 2019) |
| "Fentanyl is an opioid analgesic that is available as injection and transdermal patch products for the management of acute and chronic pain." | 1.51 | Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity. ( Ajjarapu, SS; Bae, J; Dhawan, T; Maurya, A; Murthy, SN; Rangappa, S, 2019) |
| "Infective endocarditis is associated with significant morbidity and mortality, despite advances in diagnosis and treatment strategies." | 1.51 | No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. ( Gorman, M; McCann, M; McKeown, B, 2019) |
| " Predictors of poorer neurocognitive function were midazolam dosage >3 mg (P<0." | 1.51 | Comparison of the Effects of Midazolam/Fentanyl, Midazolam/Propofol, and Midazolam/Fentanyl/Propofol on Cognitive Function After Gastrointestinal Endoscopy. ( Riordan, S; Seck, V; Thompson, R; Wong, S, 2019) |
| "Fentanyl was administered 9672 times to 4318 patients." | 1.48 | Opioid analgesia on the battlefield: a retrospective review of data from Operation HERRICK. ( Hooper, C; Lewis, P; Wright, C, 2018) |
| "The administration of ketamine during burn wound care using a critical care RN-driven protocol was associated with reduced opioid and benzodiazepine requirements and few adverse effects." | 1.48 | CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care. ( Baumgartner, L; MacLaren, R; Townsend, N; Winkelman, K, 2018) |
| " Because of its strong analgesic activity and dosage form, fentanyl has become one of the first choices for severe and moderate pain in clinical practice." | 1.48 | Comparison of the use of different analgesics in the course of anesthesia care based on pharmacoeconomics. ( Jing, C; Ping, Y; Qing, J, 2018) |
| " ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children." | 1.46 | ABCB1 genotype is associated with fentanyl requirements in critically ill children. ( Au, AK; Clark, RSB; Conley, YP; Empey, PE; Horvat, CM; Kochanek, PM; Li, L; Poloyac, SM, 2017) |
| " To evaluate the pharmacokinetic profile of TFS in healthy adult rhesus macaques, we used a 2-period, 2-treatment crossover study of a single topical administration of 1." | 1.46 | Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques ( ( Christe, KL; Hill, AE; Knych, HK; Lemoy, MJ; Salyards, GW, 2017) |
| " There was no difference in pain score reduction; however, repeat dosing was less frequent for patients receiving INF (16% vs." | 1.46 | Intranasal Fentanyl and Quality of Pediatric Acute Care. ( Adelgais, KM; Brent, A; Deakyne, S; Massanari, D; Sills, MR; Tong, S; Wathen, J, 2017) |
| " There were statistically significant differences between new and experienced providers in the distribution of responses for survey items regarding how the importance of treating pain in children was learned, overall comfort with pediatric patients, receiving negative responses from superiors about giving pediatric patients analgesics, and usefulness of the Broselow tape for dosing fentanyl for children." | 1.46 | An Assessment of Newly Identified Barriers to and Enablers for Prehospital Pediatric Pain Management. ( Cushman, JT; Jones, CMC; Li, T; Shah, MN; Whitley, DE; Williams, DM, 2017) |
| " This study investigated the patterns of opioid prescribing and characterized the dosing and duration of opioid use in patients with noncancer and cancer pain." | 1.46 | Dose and Duration of Opioid Use in Patients with Cancer and Noncancer Pain at an Outpatient Hospital Setting in Malaysia. ( Choy, LW; Ismail, CR; Rahman, NA; Zin, CS, 2017) |
| " Nonetheless, careful deliberation is necessary because of the slow effects and difficulty with dosage adjustment." | 1.43 | [Use of Transdermal Fentanyl in a Hospital]. ( Kikuchi, N; Sako, A; Watanabe, A; Yoshida, S; Yoshikawa, Y, 2016) |
| "Fentanyl was preferred for paediatric patients and ketamine was preferentially administered for severe pain by physicians who had more medical experience or had trained in anaesthesia." | 1.43 | A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury. ( Albrecht, E; Eidenbenz, D; Hugli, O; Pasquier, M; Taffé, P, 2016) |
| " For constipation, M6G, fentanyl and buprenorphine were full agonists, oxycodone was a partial agonist, morphine produced a bell-shaped dose-response curve, whereas DPDPE and U69,593 were inactive." | 1.42 | In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. ( Kuo, A; Meutermans, W; Smith, MT; Wyse, BD, 2015) |
| " The objective of this study was to observe whether the dosing time of 6 narcotic analgesics in mice affected their efficacy, pain tolerance and recovery of tolerance." | 1.42 | Chronopharmacology of analgesic effect and tolerance induced by six narcotic analgesics in mice. ( Chang, MJ; Jin, JJ; Li, XP; Liu, D; Luo, L; Xu, YJ; Yu, ZQ; Zhang, CL, 2015) |
| "Pain is believed to be undertreated in patients with dementia; however, no larger studies have been conducted." | 1.42 | Frequent use of opioids in patients with dementia and nursing home residents: A study of the entire elderly population of Denmark. ( Astrup, A; Gasse, C; Jensen-Dahm, C; Mortensen, PB; Waldemar, G, 2015) |
| "Mean fentanyl dose was 734 μg and duration of use was 3." | 1.42 | Patient-controlled intranasal fentanyl analgesia: a pilot study to assess practicality and tolerability during childbirth. ( Evans, B; Kerr, D; Taylor, D, 2015) |
| "We used oxycodone hydrochloride to treat a sharp pain resulting from cataplectic cancer in the jejunal tube, but this provided only limited pain relief." | 1.42 | [Efficacy of a fentanyl citrate buccal tablet for esophageal cancer pain management in a patient unable to take oral medication]. ( Baba, H; Fujimura, Y; Nakahara, O; Ohshima, S, 2015) |
| "The state of opioid consumption among cancer patients has never been comprehensively investigated in Japan." | 1.42 | Accuracy of using Diagnosis Procedure Combination administrative claims data for estimating the amount of opioid consumption among cancer patients in Japan. ( Higashi, T; Iwamoto, M; Kawaguchi, T; Matoba, M; Miura, H; Tanaka, S; Yamashita, I; Yoshida, S; Yoshimoto, T, 2015) |
| "Fentanyl-induced neurotoxicity is an uncommon adverse effect of fentanyl and is seldom seen in pediatric palliative care practice." | 1.42 | Fentanyl-Induced Neurotoxicity in Children. ( Deodhar, J; Muckaden, MA; Ostwal, S; Salins, N, 2015) |
| "One of the key issues in the treatment of pain is to choose the appropriate route and dosage form of analgesics for each individual patient in pain." | 1.42 | [Understanding Oral and Nasal Mucosal Absorption of Fentanyl, and Rectal Absorption of Buprenorphine]. ( Kato, Y; Kubota, Y; Shimoyama, M; Shimoyama, N, 2015) |
| " We describe here an analogue of 1 with an added C-terminal β-glucosylserine residue, Ser(β-Glc)NH2, a modification that has previously been shown to improve bioavailability of opioid peptides." | 1.40 | Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. ( Anand, JP; Jutkiewicz, EM; Mosberg, HI; Porter, V; Sobczyk-Kojiro, K; Traynor, JR; Yeomans, L, 2014) |
| "Morphine was the most frequently prescribed, but the utilization of oxycodone, buprenorphine and fentanyl increased markedly over time." | 1.40 | Changes in trends and pattern of strong opioid prescribing in primary care. ( Chen, LC; Knaggs, RD; Zin, CS, 2014) |
| "Rats treated with fentanyl in RGD liposome and POD device exhibited greater analgesic effect, as compared with the free drug counterpart (AUC(effect) = 1387." | 1.40 | Aerosol-stable peptide-coated liposome nanoparticles: a proof-of-concept study with opioid fentanyl in enhancing analgesic effects and reducing plasma drug exposure. ( Ho, RJ; Hoekman, JD; Srivastava, P, 2014) |
| "Pain was the most common adverse reaction reported." | 1.40 | Medication errors related to transdermal opioid patches: lessons from a regional incident reporting system. ( Hägg, S; Holmlund, M; Lövborg, H, 2014) |
| "Fentanyl was equally effective and 1000× more potent than morphine to inhibit i." | 1.40 | Dissociation of immunosuppressive and nociceptive effects of fentanyl, but not morphine, after repeated administration in mice: fentanyl-induced sensitization to LPS. ( Cruz, SL; González-Espinosa, C; Molina-Martínez, LM, 2014) |
| "A fentanyl patch was also placed for relieving cancer pain, but was removed 4 months later because the pain disappeared." | 1.40 | [A case of recurrent colon cancer with improvement in prognosis and cancer pain after surgical intervention]. ( Fujisaki, S; Sakurai, K; Takashina, M; Takayama, T; Tomita, R, 2014) |
| " Opioid dosage was indicative of syndrome severity and correlated with other physiological parameters measured." | 1.39 | Long-term analysis of Irukandji stings in Far North Queensland. ( Carrette, TJ; Seymour, JJ, 2013) |
| "Pain was associated with younger age (p < 0." | 1.38 | The burden of endoscopic retrograde cholangiopancreatography (ERCP) performed with the patient under conscious sedation. ( Jeurnink, SM; Kuipers, E; Siersema, P; Steyerberg, E, 2012) |
| "loperamide was abolished by i." | 1.38 | Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. ( Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M, 2012) |
| "Before intratracheal suctioning, patients had RASS scores of -1." | 1.38 | Assessment of pain in sedated and mechanically ventilated patients: an observational study. ( Hamers, JP; Hantikainen, V; Jakob, SM; Jeitziner, MM; Rohrer, O; Schwendimann, R, 2012) |
| " Maximum venous concentration and area under the concentration curve were approximately two-fold lower in the patient group for an equivalent dose, suggesting either reduced bioavailability or increased clearance: maximum venous concentration 0." | 1.38 | Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort. ( Chapman, MJ; Charlton, CS; Fajumi, AO; Krishnamurthy, RB; Lai, S; Ludbrook, GL; Macintyre, PE; Martinez, AM; McConnell, H; O'Connor, SN; Ong, J; Ousley, RM; Upton, RN, 2012) |
| "Emergent adult trauma patients were included with an initial prehospital Glasgow Coma Scale score of ≥13 and systolic blood pressure >90 mm Hg." | 1.38 | Safety of prehospital intravenous fentanyl for adult trauma patients. ( Byyny, RL; Colwell, CB; Gravitz, C; Haukoos, JS; Liao, MM; McVaney, KE; Soriya, GC, 2012) |
| "Von Frey filaments were used to measure mechanical allodynia of the hind paw and abdomen." | 1.38 | Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. ( Feng, XM; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, YQ; Wang, ZF; Wu, GC; Xia, F; Xiao, S, 2012) |
| " Although intravenously administered morphine can readily provide rapid and effective prehospital analgesia, oral transmucosal fentanyl citrate (OTFC) is a safe alternative that does not require intravenous access." | 1.38 | Safety and efficacy of oral transmucosal fentanyl citrate for prehospital pain control on the battlefield. ( Fowler, M; Kotwal, RS; McGhee, L; McManus, JG; Pennardt, A; Talbot, TS; Wedmore, IS, 2012) |
| "This study involved 320 cancer patients from four Northern European countries." | 1.37 | Multi-centre European study of breakthrough cancer pain: pain characteristics and patient perceptions of current and potential management strategies. ( Andersen, S; Buchanan, A; Damkier, A; Davies, A; Nauck, F; Radbruch, L; Sjolund, KF; Stenberg, M; Vejlgaard, T; Zeppetella, G, 2011) |
| " First of all, once assessed that all drugs induced dose-related antinociceptive effects, they were mixed in fixed ratio (1:1) combinations and a synergistic drug-drug interaction was obtained in all circumstances." | 1.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| " In the switching study DDD indicated a reduction in analgesic dosing and OMEQ an increase when switching from WHO step II to III." | 1.37 | Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses. ( Borchgrevink, P; Dale, O; Fredheim, O; Hamunen, K; Mellbye, A; Svendsen, K, 2011) |
| "Fentanyl is an opioid initially developed for parenteral administration." | 1.36 | Formulations of fentanyl for the management of pain. ( Grape, S; Lauer, S; Schug, BS; Schug, SA, 2010) |
| " To determine the dosing frequency of sustained-release opioids (morphine, oxycodone, and transdermal fentanyl) and the prevalence of end-of-dose failure in clinical practice, a patient-reported survey was performed." | 1.36 | The dosing frequency of sustained-release opioids and the prevalence of end-of-dose failure in cancer pain control: a Korean multicenter study. ( Ahn, JS; Kim, DY; Kim, SY; Ryoo, BY; Shin, DB; Song, HS; Yim, CY, 2010) |
| "Breakthrough pain is defined as transitory flares of pain." | 1.36 | Recent development in therapeutics for breakthrough pain. ( Davis, MP, 2010) |
| "Incidence of newly diagnosed cancers is also the second highest in the Gulf with 11%." | 1.36 | Historical perspectives and trends in the management of pain for cancer patients in oman. ( Mahfudh, SS, 2010) |
| " We show that the opioid Fentanyl, and its structurally similar sedative Zolpidem, can be embedded into metakaolin based geopolymer pellets to provide prolonged release dosage forms with mechanical strengths of the same order of magnitude as that of human teeth." | 1.36 | Mechanically strong geopolymers offer new possibilities in treatment of chronic pain. ( Bredenberg, S; Engqvist, H; Forsgren, J; Jämstorp, E; Strømme, M, 2010) |
| "Fentanyl patch is an alternative for children who cannot tolerate morphine." | 1.35 | Fentanyl patch for stable chronic pain in children: new indication. Used fentanyl patches should be handled with care. ( , 2008) |
| "The femur bone cancer pain model was developed by implanting mouse osteolytic tumor cells (NCTC 2472) into the intramedulla of the femur in C3H/HeN mice." | 1.35 | Oxycodone-induced analgesic effects in a bone cancer pain model in mice. ( Ito, H; Kato, A; Kihara, T; Matsumoto, M; Minami, K; Narita, M; Orita, S; Suzuki, T; Tomii, T, 2008) |
| "Pain is an important and often under-treated symptom of life-threatening illness." | 1.35 | [Analgesics and palliative care]. ( Mathieu, N; Tuna, T, 2008) |
| "(B) Fentanyl was administered in situ to investigate the interaction with 8-OH-DPAT on phrenic nerve activity and nociceptive CFR." | 1.35 | The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo. ( Dutschmann, M; Guenther, U; Hoeft, A; Manzke, T; Putensen, C; Wrigge, H; Zinserling, J, 2009) |
| "Buprenorphine displays attributes of opioids, but also some features distinct from them." | 1.35 | Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. ( Ding, Z; Raffa, RB, 2009) |
| "MK-801 blocked and reversed hyperalgesia caused by the acute injection and continuous infusion of fentanyl, respectively, in naltrexone-treated CD-1 mice, indicating the contribution of NMDA receptors to fentanyl hyperalgesia." | 1.35 | Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. ( Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR, 2009) |
| "Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies." | 1.35 | Magnesium modifies fentanyl-induced local antinociception and hyperalgesia. ( Gunay, I; Gunes, Y; Mert, T; Ozcengiz, D, 2009) |
| "Cancer pain is common, occurring in up to 60% of patients and opioid conversion may be required for effective pain management." | 1.35 | Inconsistencies in opioid equianalgesic ratios: clinical and research implications. ( Kutner, JS; Linnebur, SA; O'Bryant, CL; Yamashita, TE, 2008) |
| "Children with solid tumors outside the central nervous system were likely to receive more opioids, be given multiple different opioids, and receive opioids in the last month." | 1.35 | Opioid use in palliative care of children and young people with cancer. ( Childs, M; Collins, GS; Goldman, A; Hain, R; Hewitt, M, 2008) |
| "Pain was well controlled." | 1.35 | Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008) |
| "Assisted sedation is a safe and easy method for pain free PVP procedures." | 1.35 | Assisted sedation: a safe and easy method for pain-free percutaneous vertebroplasty. ( Andreula, C; Della Puppa, A; Frass, M, 2008) |
| " Demographic data, time in ED, and dosage of each medication given were abstracted." | 1.35 | Inadequate provision of postintubation anxiolysis and analgesia in the ED. ( Bonomo, JB; Butler, AS; Lindsell, CJ; Venkat, A, 2008) |
| "We present two cases of scorpion envenomation with different and rare clinical situations with a short review of the literature." | 1.35 | Unusual presentations of scorpion envenomation. ( Demir, M; Ranu Alpay, N; Satar, S; Sebe, A; Topal, M, 2008) |
| "fentanyl was naloxone reversible and potentiated exclusively in inflamed and NGF-treated paws." | 1.34 | Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain. ( Cheppudira, BP; Fischer, O; Hellweg, R; Hofmann, J; Mousa, SA; Schäfer, M; Shaqura, M, 2007) |
| "Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain." | 1.34 | Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 1.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "Many Japanese cancer patients experience severe pain although they and their families hope to be pain free at the end of their lives." | 1.34 | Toward freedom from cancer pain in Japan. ( Otsuka, K; Yasuhara, H, 2007) |
| "A dose-response relationship between fentanyl and artificial feeding has not been reported elsewhere." | 1.33 | The impact of intrapartum analgesia on infant feeding. ( Bradshaw, C; Emery, S; Friswell, W; Jordan, S; Watkins, A, 2005) |
| "Fentanyl was provided frequently, with good effect and minimal cardiorespiratory consequence." | 1.33 | Fentanyl trauma analgesia use in air medical scene transports. ( Biddinger, PD; Harrison, T; Rago, O; Thomas, SH; Wedel, SK, 2005) |
| " The bioavailability of fentanyl was statistically different according to patient age." | 1.33 | Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients. ( Astre, C; Bressolle, F; Caumette, L; Coulouma, R; Culine, S; Garcia, F; Pinguet, F; Solassol, I; Thézenas, S, 2005) |
| "However, if pain is unmanageable in the outpatient department, we believe that options include hospital admission, using the contained method of application or, in the worst case scenario, cessation of treatment." | 1.33 | Determining pain levels in patients treated with maggot debridement therapy. ( Budding, T; Oskam, J; Steenvoorde, P, 2005) |
| " To analyze possible interaction between these two drugs, a dose-response curve to fentanyl plus a fixed dose of R-(alpha)-methylhistamine (0." | 1.33 | Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(alpha)-methylhistamine, on the inhibition of nociception and plasma extravasation in mice. ( Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Puig, MM; Sánchez, S, 2006) |
| "Pain affects many cancer patients, and in advanced stages of the disease it can significantly affect the quality of their lives." | 1.33 | Three-cycle fentanyl patch system significantly improves pain control in gynecologic cancer. ( Hayashi, M; Kanamori, C; Kanamori, T; Kanzaki, H; Yorioka, H, 2006) |
| "Fentanyl is a synthetic, lipophilic opioid, more potent than morphine, and achieves peak effects after intravenous administration in 5 minutes." | 1.32 | Intravenous fentanyl for cancer pain: a "fast titration" protocol for the emergency room. ( Martins, M; Soares, LG; Uchoa, R, 2003) |
| "For patients without cancer, rates of therapy switching at 6 months were 10." | 1.32 | Therapy switching in patients receiving long-acting opioids. ( Berger, A; Delea, TE; Goodman, S; Hoffman, DL; Oster, G; Seifeldin, R, 2004) |
| "Morphine side effects were reduced in some patients who changed to transdermal fentanyl, but there was no reduction in those who needed high-dose morphine for rescue analgesia." | 1.32 | A study of transdermal fentanyl in cancer pain at Aichi-Cancer Center. ( Hasegawa, M; Hosoda, R; Kamiya, Y; Kato, K; Mizaki, T; Nitta, M; Yamazaki, S, 2004) |
| "Fentanyl was discontinued, fluids were restricted, and 3% saline was started." | 1.31 | Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion. ( Afrin, LB; Hall, PD; Kokko, H, 2002) |
| "Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H." | 1.31 | Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Clonidine was also evaluated in combination with ketamine and dextromethorphan." | 1.31 | Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. ( Baker, AK; Hoffmann, VL; Meert, TF, 2002) |
| "In untreated mice, morphine, fentanyl, clonidine, oxymetazoline, desipramine and lidocaine, but not MK801, produced dose-related antinociception when tested using a 55 degrees C water tail-flick test." | 1.31 | Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice. ( Shannon, HE; Womer, DE, 2000) |
| " As assessed by cumulative dose-response approach in the tail-flick test, administration of 10 mg kg(-1) morphine bid s." | 1.31 | Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice. ( Kozela, E; Pilc, A; Popik, P, 2000) |
| "Ohmefentanyl is a very potent and highly selective agonist for mu-opioid receptors." | 1.31 | Analgesic activity and opioid receptor selectivity of stereoisomers of ohmefentanyl isothiocyanate. ( Chen, BY; Chen, XJ; Chi, ZQ; Jin, WQ; Zhu, YC, 2001) |
| "Fentanyl has a 7 gram usage versus a 100 gram INCB allocation." | 1.31 | Opioid use in chronic pain management in the Philippines. ( Espinosa, EL; Harder, SM; Javier, FO; Magpantay, LA; Unite, MA, 2001) |
| "Most patients suffered from cancer pain and only 11 patients had chronic pain from non-malignant disease." | 1.31 | Transdermal fentanyl for the management of cancer pain: a survey of 1005 patients. ( Brunsch-Radbruch, A; Grond, S; Lehmann, KA; Petzke, F; Radbruch, L; Sabatowski, R, 2001) |
| "Ketamine has been found to exert antinociceptive effects in animals and to be analgesic at subanaesthetic doses in humans." | 1.31 | Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems. ( Bajunaki, E; Goodchild, CS; Nadeson, R; Tucker, A, 2002) |
| "Yet, surveys of nurses' knowledge of cancer pain management reveal serious knowledge deficits that could adversely affect the care of patients with cancer pain." | 1.30 | Nurses' knowledge about equianalgesia and opioid dosing. ( Ferrell, BR; McCaffery, M, 1997) |
| "Propofol and fentanyl were administered via computer-assisted continuous infusion to provide stable concentrations and to allow equilibration between plasma-blood and effect-site concentrations." | 1.30 | Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli. ( Ikeda, K; Kazama, T; Morita, K, 1997) |
| "Morphine was approximately 7440 times less potent than dihydroetorphine while heroin and fentanyl were approximately 163." | 1.30 | Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain. ( Hairston, CT; Harris, LS; Lutz, PO; Martin, TJ; Porreca, F, 1998) |
| "Postfentanyl vital signs were reviewed for evidence of hemodynamic or ventilatory compromise." | 1.30 | Prehospital fentanyl analgesia in air-transported pediatric trauma patients. ( DeVellis, P; Stein, JP; Thomas, SH; Vinci, RJ; Wedel, SK, 1998) |
| "To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug." | 1.30 | Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999) |
| "The patients included 14 intravenous drug abusers, five of whom were on methadone maintenance." | 1.29 | Evaluation of recalcitrant pain in HIV-infected hospitalized patients. ( Anand, A; Carmosino, L; Glatt, AE, 1994) |
| "5 h Tmax was observed." | 1.29 | In vivo iontophoresis of fentanyl and sufentanil in rats: pharmacokinetics and acute antinociceptive effects. ( Préat, V; Thysman, S, 1993) |
| " Recommendations for managing opioid-induced muscle hyperactivity include reduction of the opioid dosage and/or administration of clonazepam therapy." | 1.29 | Opioid-induced muscle activity: implications for managing chronic pain. ( Levitt, R; Steen, PD; Sylvester, RK, 1995) |
| "Shivering and hiccoughing were noted in two and four cases, respectively." | 1.29 | Methohexital infusion technique for conscious sedation. ( Buckley, M; Johns, FR; Ziccardi, VB, 1996) |
| "The triggering of phantom limb pain by subarachnoid or epidural anaesthesia has been well described leading to the suggestion that neuraxial regional anaesthesia is relatively contraindicated in lower limb amputees." | 1.29 | Regional anaesthesia for repeat Caesarean section in a patient with phantom limb pain. ( Carrie, LE; Glynn, CJ; Uncles, DR, 1996) |
| " Although anecdotal experience exists concerning the use of fentanyl PCA in adults, dosing guidelines in children must depend on consideration of the current narcotic regimen and the use of equipotent doses of fentanyl." | 1.28 | Patient-controlled analgesia with fentanyl in children. ( Baker, DK; Tobias, JD, 1992) |
| "This is a report of the results of 25 experiments in five rats investigating the dose-response relationship for the antinociceptive effects of chlordiazepoxide given intrathecally in the dose range 0." | 1.28 | Spinally mediated antinociception following intrathecal chlordiazepoxide--further evidence for a benzodiazepine spinal analgesic effect. ( Boulter, N; Gent, JP; Goodchild, CS; Serrao, JM, 1991) |
| " On the basis of our dose-response data, we suggest that, in mice, kappa and mu, but not delta, opioid receptors modulate tonic pain perception at both spinal and supraspinal loci." | 1.28 | Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists. ( Cowan, A; Murray, CW, 1991) |
| " The A50 (dose producing 50% MPE) for each drug or drug combination was determined from the dose-response curve." | 1.28 | Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy. ( Bagley, J; Harris, S; Lin, BS; Lloyd, P; Messineo, E; Ossipov, MH, 1990) |
| " Flumazenil (Ro 15-1788) administration caused a parallel shift to the right of the dose-response curve for midazolam spinal analgesia." | 1.28 | On the mechanism by which midazolam causes spinally mediated analgesia. ( Edwards, M; Gent, JP; Goodchild, CS; Serrao, JM, 1990) |
| "We report on a patient with acute pancreatitis whose pain was resistant to simultaneous administration of morphine, procaine and Buscopan." | 1.28 | [The value of epidural analgesia in acute pancreatitis]. ( Borgeat, A; Chanson, C; Nicolet, A; Schwander, D, 1990) |
| " dose-response curves for the effect of the chronic drug given as a bolus." | 1.28 | Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion. ( Stevens, CW; Yaksh, TL, 1989) |
| "Naloxone did, however, suppress FI and WI following deprivation and inhibited the recovery of body weight thereafter." | 1.27 | Long-term blockade of mu-opioid receptors suggests a role in control of ingestive behaviour, body weight and core temperature in the rat. ( Millan, MJ; Morris, BJ, 1988) |
| "However in the acute postoperative pain group other factors such as depletion of endorphins by drugs used for anesthesia or due to surgical stress cannot be excluded." | 1.26 | [Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients]. ( Laorden, ML; Miralles, F; Olaso, MJ; Puig, MM, 1982) |
| "Both approaches give insight into the results: the technique copes with biological variability; anticipating pain induced by fear disappears; the feedback strategy works well and patients adapt to a wide range in prescriptions; intermittent administration makes more efficient use of the analgesic; an optimal result is demonstrated in studies comparing on-demand analgesia with the normal IM-regime and epidural analgesia; continuity in pain relief can be obtained in routine clinical practice." | 1.26 | Postoperative pain relief by demand analgesia. ( Brugmans, J; Peeters, M, 1980) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 1.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| "Xylazine was significantly more effective in obtunding deep pain (P less than 0." | 1.26 | Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979) |
Research
Studies (1,200)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (9.67) | 18.7374 |
| 1990's | 210 (17.50) | 18.2507 |
| 2000's | 415 (34.58) | 29.6817 |
| 2010's | 343 (28.58) | 24.3611 |
| 2020's | 116 (9.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mosberg, HI | 1 |
| Yeomans, L | 1 |
| Anand, JP | 1 |
| Porter, V | 1 |
| Sobczyk-Kojiro, K | 1 |
| Traynor, JR | 1 |
| Jutkiewicz, EM | 1 |
| Kondo, A | 1 |
| Murakami, T | 1 |
| Fujii, T | 2 |
| Tatsumi, M | 1 |
| Ueda-Sakane, Y | 1 |
| Ueda, Y | 1 |
| Yamauchi, I | 1 |
| Ogura, M | 1 |
| Taura, D | 1 |
| Inagaki, N | 1 |
| Lugli, L | 1 |
| Spada, C | 1 |
| Garetti, E | 3 |
| Guidotti, I | 1 |
| Roversi, MF | 1 |
| Della Casa, E | 1 |
| Bedetti, L | 1 |
| Lucaccioni, L | 1 |
| Pugliese, M | 1 |
| Ferrari, F | 2 |
| Iughetti, L | 1 |
| Lago, P | 3 |
| Berardi, A | 1 |
| Barker, KE | 1 |
| Lecznar, AJ | 1 |
| Schumacher, JM | 1 |
| Morris, JS | 1 |
| Gutstein, HB | 1 |
| Carenzo, L | 1 |
| McDonald, A | 1 |
| Grier, G | 1 |
| Madathil, S | 1 |
| Thomas, D | 1 |
| Chandra, P | 1 |
| Agarwal, R | 1 |
| Sankar, MJ | 1 |
| Thukral, A | 1 |
| Deorari, A | 1 |
| Oto, Y | 1 |
| Momo, K | 1 |
| Uchikura, T | 1 |
| Tanaka, K | 3 |
| Sasaki, T | 1 |
| Aminnejad, R | 1 |
| Hormati, A | 1 |
| Shafiee, H | 1 |
| Alemi, F | 1 |
| Hormati, M | 1 |
| Saeidi, M | 1 |
| Ahmadpour, S | 1 |
| Sabouri, SM | 1 |
| Aghaali, M | 1 |
| Huang, SM | 1 |
| Hsu, H | 1 |
| Hii, IH | 1 |
| Chang, CH | 2 |
| Qiu, J | 1 |
| Xie, M | 1 |
| Donnenfeld, ED | 1 |
| Mychajlyszyn, D | 1 |
| Mychajlyszyn, A | 1 |
| Stein, R | 1 |
| Wang, XX | 1 |
| Cui, LL | 1 |
| Gan, SF | 1 |
| Zhang, ZR | 1 |
| Xiao, J | 1 |
| Li, CH | 2 |
| Luo, F | 2 |
| Sirohiya, P | 1 |
| Kumar, V | 1 |
| Mittal, S | 1 |
| Gupta, N | 1 |
| Garg, R | 2 |
| Bharati, SJ | 1 |
| Mishra, S | 1 |
| Hadda, V | 1 |
| Mohan, A | 1 |
| Sagiraju, HKR | 1 |
| Bhatnagar, S | 1 |
| Madan, K | 1 |
| Latev, A | 1 |
| Baer, J | 1 |
| Sharpe, S | 1 |
| Gupta, C | 1 |
| Feliciano, C | 1 |
| Friedman, BW | 1 |
| Zhou, S | 1 |
| Bi, J | 1 |
| Zhao, W | 1 |
| Zhao, J | 1 |
| Wan, H | 1 |
| Wang, S | 1 |
| Bilel, S | 1 |
| Azevedo Neto, J | 1 |
| Arfè, R | 1 |
| Tirri, M | 1 |
| Gaudio, RM | 1 |
| Fantinati, A | 1 |
| Bernardi, T | 1 |
| Boccuto, F | 1 |
| Marchetti, B | 1 |
| Corli, G | 1 |
| Serpelloni, G | 1 |
| De-Giorgio, F | 1 |
| Malfacini, D | 2 |
| Trapella, C | 1 |
| Calo', G | 1 |
| Marti, M | 1 |
| Hayashi, M | 3 |
| Shimamura, Y | 1 |
| Shiroshita, A | 1 |
| Bahrami, F | 2 |
| Rossi, RM | 2 |
| Defraeye, T | 2 |
| Tang, LJ | 1 |
| Han, J | 1 |
| Feng, YJ | 1 |
| Pu, CX | 1 |
| Zhang, Y | 4 |
| Wallen, TE | 1 |
| Elson, NC | 1 |
| Singer, KE | 1 |
| Hayes, HV | 1 |
| Salvator, A | 1 |
| Droege, CA | 1 |
| Nomellini, V | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Xia, W | 1 |
| Yang, C | 2 |
| Weitzman, ER | 1 |
| Kossowsky, J | 1 |
| Blakemore, LM | 1 |
| Cox, R | 1 |
| Dowling, DJ | 1 |
| Levy, O | 1 |
| Needles, EW | 1 |
| Levy, S | 1 |
| Wang, JJ | 1 |
| Teng, SF | 1 |
| Chu, YR | 1 |
| Chu, CC | 1 |
| Ho, CH | 1 |
| Chu, LL | 1 |
| Thirunavukarasu, AJ | 1 |
| Hassan, R | 1 |
| Savant, SV | 1 |
| Hamilton, DL | 1 |
| Getsy, PM | 1 |
| Baby, SM | 2 |
| May, WJ | 2 |
| Lewis, THJ | 1 |
| Bates, JN | 3 |
| Hsieh, YH | 1 |
| Gaston, B | 1 |
| Lewis, SJ | 2 |
| Langford, B | 1 |
| Pittelkow, TP | 1 |
| Abcejo, AS | 1 |
| Ruffin, TB | 1 |
| Salinero, E | 1 |
| Papa, L | 1 |
| Cramm, K | 1 |
| Florez, C | 1 |
| Chen, JG | 1 |
| Ramirez, J | 1 |
| Lynch, TV | 1 |
| Callas, PW | 1 |
| Peterson, TD | 1 |
| Schlein, SM | 1 |
| Pyle, A | 1 |
| Kelty, E | 1 |
| Sanfilippo, F | 4 |
| Murray, K | 1 |
| Preen, D | 1 |
| Zhu, H | 2 |
| Xiao, H | 1 |
| Lu, G | 1 |
| Fang, S | 1 |
| Chin, J | 1 |
| McGrath, M | 1 |
| Lokken, E | 1 |
| Upegui, CD | 1 |
| Prager, S | 1 |
| Micks, E | 1 |
| Azarfar, A | 1 |
| Ravanshad, Y | 1 |
| Golsorkhi, M | 1 |
| Zahiri, E | 1 |
| Gharavi Fard, M | 1 |
| Akhondi, M | 1 |
| Ghodsi, A | 1 |
| Ravanshad, S | 1 |
| Efune, PN | 1 |
| Rebstock, SE | 1 |
| Nihadha, PM | 1 |
| Chugh, A | 1 |
| Kaur, A | 2 |
| Kumar, S | 1 |
| Naveen, KH | 1 |
| Bhatia, PK | 1 |
| Kumar, P | 1 |
| Chaudhry, K | 2 |
| Puig, S | 1 |
| Shelton, MA | 1 |
| Barko, K | 1 |
| Seney, ML | 1 |
| Logan, RW | 1 |
| Maarof, SR | 1 |
| Ahmad, CA | 1 |
| Atkins, L | 1 |
| Devol, EB | 1 |
| Hussain, A | 1 |
| Abdullah, KL | 1 |
| Hudson, IL | 1 |
| Staudt, AM | 1 |
| Burgess, M | 1 |
| Hinojosa-Laborde, C | 3 |
| Schauer, SG | 1 |
| Newberry, RK | 1 |
| Ryan, KL | 2 |
| VanFosson, CA | 1 |
| Campos-Pérez, W | 1 |
| Ramírez-Plascencia, L | 1 |
| Pérez-Robles, M | 1 |
| Rivera-Valdés, JJ | 1 |
| Sánchez-Muñoz, P | 1 |
| Pérez-Vargas, L | 1 |
| González-Landeros, D | 1 |
| Cuevas, JHM | 1 |
| Martínez-López, E | 1 |
| Nakar, H | 1 |
| Sorkin, A | 1 |
| Nadler, R | 1 |
| Tsur, AM | 1 |
| Gelikas, S | 1 |
| Avital, G | 1 |
| Glassberg, E | 1 |
| Bader, T | 1 |
| Fridrich, L | 1 |
| Chen, J | 2 |
| Benov, A | 1 |
| Bueno-Serrano, G | 1 |
| Alcoba-García, MP | 1 |
| Tabares-Jiménez, J | 1 |
| González-López, R | 1 |
| Llanos-Jiménez, L | 1 |
| Mahillo-Fernández, I | 1 |
| González-Enguita, C | 1 |
| Monsereenusorn, C | 2 |
| Malaithong, W | 1 |
| Lertvivatpong, N | 1 |
| Photia, A | 1 |
| Rujkijyanont, P | 2 |
| Traivaree, C | 2 |
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| Pesce, A | 2 |
| Tran, K | 2 |
| Thomas, R | 2 |
| Ackerman, G | 1 |
| Krock, K | 2 |
| Dietrich, CG | 1 |
| Kottmann, T | 1 |
| Voß, HW | 1 |
| Lorenz, R | 1 |
| Ishii, H | 3 |
| Kokubun, H | 5 |
| Tabata, KI | 3 |
| Kanai, A | 4 |
| LA Via, L | 3 |
| Santonocito, C | 3 |
| Bartolotta, N | 3 |
| Lanzafame, B | 3 |
| Morgana, A | 3 |
| Continella, C | 3 |
| Cirica, G | 3 |
| Astuto, M | 3 |
| Tavares Mendonça, F | 3 |
| de Assis Feitosa Junior, A | 3 |
| Nogueira, H | 3 |
| Roncolato, H | 3 |
| Sousa Goveia, C | 3 |
| Jin, Y | 3 |
| Yu, X | 3 |
| Hu, S | 3 |
| Liu, L | 3 |
| Wang, B | 3 |
| Feng, Y | 3 |
| Li, Y | 5 |
| Xiong, B | 3 |
| Wang, L | 3 |
| Parhar, D | 2 |
| Baum, RA | 2 |
| Spouge, R | 2 |
| Yan, T | 2 |
| Ho, S | 2 |
| Hadjivassiliou, A | 2 |
| Machan, L | 2 |
| Legiehn, G | 2 |
| Klass, D | 2 |
| Dhatt, R | 2 |
| Boucher, LM | 2 |
| Liu, DM | 2 |
| Assad, O | 2 |
| Zamora, R | 2 |
| Brown, K | 2 |
| Melnitsky, L | 2 |
| Moses, J | 2 |
| Sherman, V | 2 |
| Fernando, H | 2 |
| Nehme, Z | 2 |
| Milne, C | 2 |
| O'Brien, J | 2 |
| Bernard, S | 2 |
| Stephenson, M | 2 |
| Myles, PS | 2 |
| Lefkovits, J | 2 |
| Peter, K | 2 |
| Brennan, A | 2 |
| Dinh, D | 2 |
| Andrew, E | 2 |
| Taylor, AJ | 2 |
| Smith, K | 3 |
| Stub, D | 2 |
| Hastings, G | 2 |
| Brahler, T | 2 |
| Howles-Banerji, G | 2 |
| Kotton, M | 2 |
| Price, A | 2 |
| Singer, D | 2 |
| Wrenn, SJ | 2 |
| Jobski, K | 4 |
| Bantel, C | 2 |
| Hoffmann, F | 3 |
| Zhang, J | 4 |
| Wang, X | 2 |
| Cai, Z | 1 |
| Kang, J | 1 |
| Liu, Y | 3 |
| Nie, C | 1 |
| Zhou, H | 1 |
| Rees, CA | 1 |
| Brousseau, DC | 1 |
| Ahmad, FA | 1 |
| Bennett, J | 1 |
| Bhatt, S | 1 |
| Bogie, A | 1 |
| Brown, KM | 1 |
| Casper, TC | 1 |
| Chapman, LL | 1 |
| Chumpitazi, CE | 1 |
| Cohen, DM | 1 |
| Dampier, C | 1 |
| Ellison, AM | 1 |
| Grasemann, H | 1 |
| Hatabah, D | 1 |
| Hickey, RW | 1 |
| Hsu, LL | 1 |
| Bakshi, N | 1 |
| Leibovich, S | 1 |
| Patil, P | 2 |
| Powell, EC | 1 |
| Richards, R | 1 |
| Sarnaik, S | 1 |
| Weiner, DL | 1 |
| Morris, CR | 2 |
| Pietsch, U | 1 |
| Fischer, H | 1 |
| Rüst, CA | 1 |
| Hossfeld, B | 2 |
| Grünenfelder, A | 1 |
| Wenzel, V | 1 |
| Albrecht, R | 1 |
| Zhang, H | 3 |
| Yang, L | 3 |
| Yu, Z | 1 |
| Li, D | 1 |
| Li, L | 3 |
| Li, S | 2 |
| Yan, J | 1 |
| Li, X | 2 |
| Gan, S | 1 |
| Zhang, Z | 1 |
| Zhu, P | 1 |
| Watso, JC | 1 |
| Huang, M | 1 |
| Hendrix, JM | 1 |
| Belval, LN | 1 |
| Moralez, G | 1 |
| Cramer, MN | 1 |
| Foster, J | 1 |
| Crandall, CG | 1 |
| Kulkarni, GR | 1 |
| Eimer, C | 1 |
| Reifferscheid, F | 1 |
| Jung, P | 1 |
| Rudolph, M | 1 |
| Terboven, T | 1 |
| Lorenzen, U | 1 |
| Köser, A | 1 |
| Seewald, S | 1 |
| Desomer, L | 1 |
| Tate, DJ | 1 |
| Pillay, L | 1 |
| Awadie, H | 1 |
| Sidhu, M | 1 |
| Ahlenstiel, G | 1 |
| Bourke, MJ | 1 |
| Wydall, S | 1 |
| Zolger, D | 1 |
| Owolabi, A | 1 |
| Nzekwu, B | 1 |
| Onwochei, D | 1 |
| Desai, N | 1 |
| Wang, J | 3 |
| Lu, C | 2 |
| Liu, X | 2 |
| Zhang, G | 1 |
| Gao, M | 1 |
| Liu, D | 3 |
| Zhang, X | 1 |
| Dostbil, A | 1 |
| Ince, I | 1 |
| Altinpulluk, EY | 1 |
| Perez, MF | 1 |
| Peksoz, U | 1 |
| Cimilli, G | 1 |
| Kasali, K | 1 |
| Atalay, C | 1 |
| Ozmen, O | 1 |
| Sahin, T | 1 |
| Yilmaz, EP | 1 |
| De Nys, K | 1 |
| Kara, N | 1 |
| Arman, D | 1 |
| Seymen, Z | 1 |
| Gül, A | 1 |
| Cömert, S | 1 |
| Sudo, Y | 1 |
| Seki-Nagasawa, J | 1 |
| Kajikawa, D | 1 |
| Kuratsuji, G | 1 |
| Haga, M | 1 |
| Shokraneh, F | 1 |
| Yamaji, N | 1 |
| Ota, E | 1 |
| Namba, F | 1 |
| Persad, E | 1 |
| Pizarro, AB | 1 |
| Bruschettini, M | 4 |
| Pace, L | 1 |
| Howard, M | 1 |
| Makar, E | 1 |
| Lee, J | 1 |
| Kinoshita, M | 2 |
| Olsson, E | 3 |
| Borys, F | 2 |
| Erdem, AB | 1 |
| Donmez, S | 1 |
| Sener, A | 1 |
| Hughto, JMW | 1 |
| Tapper, A | 1 |
| Rapisarda, SS | 1 |
| Stopka, TJ | 1 |
| Palacios, WR | 1 |
| Case, P | 1 |
| Silcox, J | 1 |
| Moyo, P | 1 |
| Green, TC | 1 |
| De Vries, LJ | 1 |
| Veeger, NJGM | 1 |
| Van Roon, EN | 1 |
| Lameijer, H | 1 |
| Boutin, A | 1 |
| Gouin, S | 1 |
| Bailey, B | 3 |
| Lebel, D | 1 |
| Gravel, J | 1 |
| Liu, GH | 1 |
| Liu, LW | 1 |
| Ou, LC | 1 |
| Cao, XS | 1 |
| Pang, Z | 1 |
| Wen, XJ | 1 |
| He, QY | 1 |
| Yin, B | 1 |
| Lešnik, S | 2 |
| Bren, U | 2 |
| Domratcheva, T | 1 |
| Bondar, AN | 2 |
| Prescott, MG | 1 |
| Iakovleva, E | 1 |
| Simpson, MR | 1 |
| Pedersen, SA | 1 |
| Munblit, D | 1 |
| Vallersnes, OM | 1 |
| Austad, B | 1 |
| Pessano, S | 1 |
| Romantsik, O | 1 |
| Hedayati, E | 1 |
| Morgan, MM | 1 |
| Hilgendorf, TN | 1 |
| Kandasamy, R | 1 |
| Aykanat, MC | 1 |
| Kılıç, M | 1 |
| Cimilli Öztürk, T | 1 |
| Ustaalioğlu, İ | 1 |
| Ak, R | 1 |
| Kobayashi, N | 1 |
| Watanabe, K | 2 |
| Murakami, H | 1 |
| Yamauchi, M | 1 |
| Lim, GM | 1 |
| Park, SJ | 1 |
| Park, SY | 1 |
| Kim, JH | 3 |
| Kim, JE | 1 |
| Rosner, B | 1 |
| Neicun, J | 1 |
| Yang, JC | 1 |
| Roman-Urrestarazu, A | 1 |
| Alsirafy, SA | 1 |
| Alabdullateef, SH | 1 |
| Elyamany, AM | 1 |
| Hassan, AD | 1 |
| Almashiakhi, M | 1 |
| Hao, J | 1 |
| Dong, B | 1 |
| Luo, Z | 1 |
| Grimsrud, KN | 1 |
| Lima, KM | 1 |
| Tran, NK | 1 |
| Palmieri, TL | 1 |
| Donato, J | 1 |
| Rao, K | 1 |
| Lewis, T | 1 |
| Letzen, JE | 1 |
| Mun, CJ | 1 |
| Kuwabara, H | 1 |
| Burton, EF | 1 |
| Boring, BL | 1 |
| Walls, T | 1 |
| Speed, TJ | 1 |
| Wong, DF | 1 |
| Campbell, CM | 1 |
| McPherson, C | 1 |
| Miller, SP | 1 |
| El-Dib, M | 1 |
| Massaro, AN | 1 |
| Inder, TE | 1 |
| Zhi, M | 1 |
| Diao, Y | 1 |
| Liu, S | 2 |
| Huang, Z | 1 |
| Su, X | 1 |
| Geng, S | 1 |
| Shen, L | 1 |
| Sun, J | 1 |
| Higgins, EA | 1 |
| Young, AM | 1 |
| Cain, J | 1 |
| Dulin, JD | 1 |
| Miller, MM | 1 |
| Overstreet, AN | 1 |
| Vaughan, L | 1 |
| Coyne, PJ | 1 |
| Häske, D | 1 |
| Böttiger, BW | 1 |
| Bouillon, B | 1 |
| Fischer, M | 1 |
| Gaier, G | 1 |
| Gliwitzky, B | 1 |
| Helm, M | 1 |
| Hilbert-Carius, P | 1 |
| Schempf, B | 1 |
| Wafaisade, A | 1 |
| Bernhard, M | 1 |
| Xiang, L | 1 |
| Calderon, AS | 1 |
| Klemcke, HG | 1 |
| Scott, LL | 1 |
| Davis, MP | 4 |
| Behm, B | 2 |
| Nickley, J | 1 |
| Greg Ackerman, RT | 1 |
| Yang, Z | 2 |
| Yin, Q | 1 |
| Hodošček, M | 1 |
| Stein, C | 4 |
| Jackson, LD | 1 |
| Wortzman, R | 1 |
| Chua, D | 1 |
| Selby, D | 1 |
| Bahrami, MA | 1 |
| Farhadian, N | 1 |
| Karimi, M | 1 |
| Forouzan, A | 1 |
| Masoumi, K | 1 |
| Manohar, S | 1 |
| Adler, HJ | 1 |
| Radziwon, K | 1 |
| Salvi, R | 1 |
| Jevtić, II | 1 |
| Savić Vujović, K | 1 |
| Srebro, D | 2 |
| Vučković, S | 2 |
| Ivanović, MD | 1 |
| Kostić-Rajačić, SV | 1 |
| Langford, NJ | 1 |
| Ye, Z | 1 |
| Hu, X | 1 |
| Xuan, Z | 1 |
| Yang, S | 1 |
| Mao, X | 1 |
| Rao, Y | 1 |
| Roy, PJ | 1 |
| Weltman, M | 1 |
| Dember, LM | 1 |
| Liebschutz, J | 1 |
| Jhamb, M | 1 |
| Machin, H | 1 |
| Taylor-Brown, F | 1 |
| Adami, C | 1 |
| Riley, B | 1 |
| Kawai, K | 1 |
| Irace, AL | 1 |
| Leung, P | 1 |
| Adil, E | 1 |
| Uddin, O | 1 |
| Jenne, C | 1 |
| Fox, ME | 1 |
| Arakawa, K | 1 |
| Keller, A | 1 |
| Cramer, N | 1 |
| Dou, Z | 1 |
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Clinical Trials (114)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Fentanyl for Surgical Abortions: A Randomized Controlled Noninferiority Trial[NCT04871425] | Phase 4 | 110 participants (Actual) | Interventional | 2021-04-27 | Completed | ||
| A Comparison of Opioid-containing Anesthesia Versus Opioid-free Anesthesia Using the Cortínez-Sepúlveda Model on Differential Cytokine Responses in Patients Undergoing Gastric Bypass Surgery[NCT04854252] | 40 participants (Actual) | Interventional | 2020-11-12 | Completed | |||
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| Effect of the Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy[NCT05930405] | 252 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Organ Protective Effect of Histamine H1 Receptor Antagonist In Patients With Severe Burns: A Clinical Study[NCT06126991] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| A Randomized Controlled Trial to Evaluate the Impact of Integrated Preoperative Fascia Iliaca Compartment Block (FICB) for Fast-track Surgery in Elderly Hip Fracture[NCT05857462] | 420 participants (Anticipated) | Interventional | 2023-05-31 | Recruiting | |||
| Effect of Three Different Sensory Interventions on Pain Level During Heel Blood Collection in Term Infant: A Randomized Controlled Study[NCT05526378] | 120 participants (Actual) | Interventional | 2022-12-22 | Completed | |||
| The Effect of usıng Breast mılk pacıfıer, Sucrose pacıfıer and pacıfıer ın reducıng the paın That Occurs durıng orogastrıc Tube ınsertıon ın Preterm Newborns[NCT05430100] | 73 participants (Actual) | Interventional | 2022-07-10 | Completed | |||
| Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl Using Cold Pressor Test (CPT) in Volunteers: A Randomized, Double Blind, Placebo-controlled Crossover Study.[NCT03894800] | Phase 4 | 12 participants (Actual) | Interventional | 2019-04-23 | Completed | ||
| A Survey of Management of Analgesia, Sedation and Delirium in ICU Patients in China[NCT04217915] | 800 participants (Anticipated) | Observational | 2021-07-12 | Recruiting | |||
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| Nitrous Oxide Versus Intravenous Sedation for Anesthesia[NCT02755090] | 39 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| A Randomized Controlled Trial of Intranasal Sub-dissociative Dosing of Ketamine Compared to Intranasal Fentanyl for Treatment of Pain Associated With Acute Extremity Injuries in Children[NCT02778880] | Phase 3 | 90 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Is There an Ideal Dose of Intravenous Fentanyl in the Prehospital Setting: A Prospective Cluster-randomized Comparison of 2 vs. 3 μg/kg/Transport[NCT02914678] | 7,093 participants (Actual) | Interventional | 2016-10-31 | Completed | |||
| Sedation, ANalgesia and Delirium MANagement: a Study of Medical, Surgical, Trauma, and Neuro-intensive Care Patients and a COVID-19 Sub-study.[NCT05027217] | 3,421 participants (Actual) | Observational | 2022-01-01 | Completed | |||
| Efficacy and Safety of Continuous Infusion of Fentanyl for Pain Control in Preterm Newborn on Mechanical Ventilation[NCT00571636] | Phase 3 | 128 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| Comparison of Controlled-release Oxycodone to Control Chemoradiotherapy-induced Moderate or Severe Oral Mucositis Pain in Nasopharyngeal Carcinoma Patients[NCT03045484] | 70 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
| Efficacy and Safety of Opioid Analgesics as a Preventive Treatment of Procedural Pain Associated With Turning Among Critically Ill Patients Under Mechanical Ventilation. A Controlled Clinical Trial Comparing Placebo and Fentanyl[NCT01950000] | Phase 4 | 75 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine Combined With Propofol on Tussis Reflection During Upper Gastroscopy: a Randomised, Two Centre, Three-blind, Controlled Trial[NCT05497492] | 400 participants (Anticipated) | Interventional | 2022-11-05 | Recruiting | |||
| Effects of Social Presence and Perception in Virtual Reality on Pain[NCT03157362] | 105 participants (Actual) | Interventional | 2018-02-01 | Completed | |||
| Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric Emergency Department: a Double Blind Randomized Versus Placebo Controlled Trial[NCT06181695] | Phase 3 | 182 participants (Anticipated) | Interventional | 2024-05-02 | Not yet recruiting | ||
| Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study[NCT04894864] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-10-08 | Recruiting | ||
| Effect of Intraoperative and Post-operative Opioids on Persistent Opioid Use in the Surgical Patient[NCT03367988] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Recruiting | ||
| Routine Versus on Demand Administration of Fentanyl in Colonoscopy: A Multi-centre Randomized Controlled Trial[NCT01786434] | 119 participants (Actual) | Interventional | 2012-12-10 | Completed | |||
| Randomized Controlled Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children With Suspected, Isolated Extremity Fractures in the Pediatric Emergency Department[NCT02521415] | Phase 2 | 87 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers? A Prospective, Randomized, Double-blinded Crossover Study[NCT02252458] | 21 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| A Randomized Trial of Intranasal Fentanyl Versus Placebo as an Adjunct to Lidocaine Infiltration in Adults Undergoing Abscess Incision and Drainage in the Emergency[NCT03872700] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651] | Phase 1 | 20 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Improving Labour Induction Analgesia: a Randomized Control Trial of Single Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour[NCT04011098] | Phase 1 | 5 participants (Actual) | Interventional | 2019-07-01 | Terminated (stopped due to Unable to meet recruitment numbers, lack of participation) | ||
| Prehospital Analgesia With Intra-Nasal Ketamine[NCT02753114] | Phase 4 | 120 participants (Actual) | Interventional | 2017-11-06 | Completed | ||
| Comparison of Sub-dissociative Dose Intranasal Ketamine to Intranasal Fentanyl for Treatment of Moderate to Severe Pain in Pediatric Patients Presenting to the Emergency Department: a Prospective, Randomized, Double-blind Study[NCT02388321] | Phase 4 | 22 participants (Actual) | Interventional | 2015-05-01 | Terminated (stopped due to Patients meeting inclusion criteria was low, and PI went to another institution.) | ||
| Intrathecal Magnesium Associated to Lidocaine Decreases the Incidence of the Transitory Neurologic Syndrome Following Same-day-surgery[NCT01794247] | Phase 3 | 21 participants (Actual) | Interventional | 2013-04-30 | Terminated (stopped due to low recruitment rate) | ||
| Methylnaltrexone for the Reversal of Opiate-Induced Constipation in the Intensive Care Unit[NCT01050595] | Phase 3 | 80 participants (Anticipated) | Interventional | 2009-12-31 | Recruiting | ||
| The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus[NCT03176316] | Phase 4 | 150 participants (Anticipated) | Interventional | 2018-01-02 | Recruiting | ||
| Comparing Pain Relief in Early Labor: Nitrous Oxide Versus Butorphonol Study[NCT01636999] | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn | |||
| Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain in Gynecologic Cancer Patients With Chronic Cancer Pain : A Randomized Double Blind Controlled Trial[NCT05037539] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2021-06-15 | Completed | ||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| An Open Label, Comparative, Randomised, Balanced Crossover Trial Comparing Nasal Fentanyl and Oral Transmucosal Fentanyl (Actiq®) in Breakthrough Pain in Patients With Cancer[NCT00496392] | Phase 3 | 115 participants (Anticipated) | Interventional | 2007-01-31 | Completed | ||
| A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of EN3267 for the Treatment of Breakthrough Pain in Opioid Tolerant Cancer Patients.[NCT00262678] | Phase 3 | 0 participants | Interventional | 2005-12-31 | Completed | ||
| An Observational Study to Assess the Efficacy, Safety, and Tolerability of Abstral Oral Disintegrating Tablet (ODT) for the Management of Breakthrough Cancer Pain in Korean Cancer Patients[NCT03895762] | 143 participants (Actual) | Observational | 2017-07-04 | Completed | |||
| Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair[NCT03041948] | 88 participants (Anticipated) | Interventional | 2015-09-01 | Recruiting | |||
| Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair[NCT03041935] | 90 participants (Actual) | Interventional | 2015-09-01 | Completed | |||
| Use of Binaural Beat Premedication Reduces Post-operative Morphine Consumption in Elderly Patient Submitted to Knee Surgery[NCT02712749] | 40 participants (Actual) | Interventional | 2016-09-01 | Completed | |||
| Comparison of Intubation Conditions After Induction With Propofol Associated With a Dose of Remifentanil or Sufentanil in Surgical Tooth Extraction.[NCT01910285] | Phase 4 | 70 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| Fentanyl Buccal Soluble Films Feasible Dose Range Study for Breakthrough Pain in Taiwanese Cancer Patients[NCT03669263] | 36 participants (Actual) | Interventional | 2014-11-25 | Completed | |||
| Intranasal Fentanyl Versus Placebo for Catheterization During a Voiding Cystourethrogram in Children[NCT00405444] | Phase 3 | 64 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Fentanyl Versus Midazolam as an Adjunct to Intrathecal Bupivacaine for Postoperative Analgesia in Children Undergoing Infraumbilical Surgery[NCT03592537] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2018-08-15 | Completed | ||
| Efficacy of an Internet-based Intervention for Dental Anxiety[NCT03680755] | Phase 2 | 450 participants (Anticipated) | Interventional | 2019-07-24 | Active, not recruiting | ||
| [NCT02039453] | 160 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| Comparing Time to Readiness for Discharge After Colonoscopy: Propofol and Dexmedetomidine vs Propofol Only Sedation[NCT03139279] | Phase 4 | 122 participants (Actual) | Interventional | 2017-05-05 | Completed | ||
| Midazolam With Meperidine and Dexmedetomidine vs Midazolam With Meperidine for Sedation During ERCP[NCT01404689] | Phase 4 | 110 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Dexmedetomidine Compared to Midazolam for Symptom Control in Advanced Cancer Patients: A Pilot Randomized Controlled Trial (RCT)[NCT01687751] | Phase 2 | 0 participants (Actual) | Interventional | 2012-11-30 | Withdrawn (stopped due to Study design determined to be not likely feasible) | ||
| A Multiple-Dose, Non-Randomized, Open-Label, Multicenter Study to Evaluate the Long-Term Safety and Effectiveness of EN3267 in the Treatment of Breakthrough Pain in Cancer Patients[NCT00263575] | Phase 3 | 139 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Survey of Knowledge and Attitude of Pain in Anesthesia Residents of Thailand[NCT05369923] | 140 participants (Anticipated) | Observational | 2022-10-01 | Not yet recruiting | |||
| Efficacy and Adverse Events of Morphine and Fentanyl in an Aeromedical Setting[NCT00580489] | 204 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure[NCT02684019] | Phase 3 | 60 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Smart Pain Assesment Tool Based on Internet of Things[NCT03061240] | 58 participants (Actual) | Interventional | 2017-11-20 | Completed | |||
| Music Therapy in Procedural Sedation in the Emergency Department[NCT02676206] | 60 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain[NCT00538850] | Phase 3 | 130 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Intranasal Fentanyl Versus Intravenous Morphine in the Emergency Department Treatment of Severe Painful Sickle Cell Crises in Children[NCT03682211] | Phase 4 | 31 participants (Actual) | Interventional | 2012-12-12 | Completed | ||
| Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia[NCT00137111] | Phase 3 | 501 participants (Actual) | Interventional | 2000-07-08 | Completed | ||
| Comparing Warm Versus Cool Temperature Water During Colonoscopy[NCT01322724] | 175 participants (Actual) | Interventional | 2011-06-30 | Completed | |||
| Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperal-gesia in Patients Following Recovery From Impacted Mandibular Third Molar Extraction. A Randomized, Placebo-controlled, Double-blind Crossover Study.[NCT02976337] | Phase 2 | 14 participants (Anticipated) | Interventional | 2017-10-12 | Recruiting | ||
| The Role of Endogenous Opioids in Mindfulness-based Chronic Pain Relief[NCT04034004] | Early Phase 1 | 88 participants (Actual) | Interventional | 2021-01-01 | Completed | ||
| Impact of Totally Transdermal Sedation in the Weaning From Remifentanil Infusion Among Critically Ill Patients Undergoing Mechanical Ventilation: a Pilot Randomized-controlled Study (The TOES Trial)[NCT04204967] | Phase 2 | 24 participants (Anticipated) | Interventional | 2021-02-15 | Recruiting | ||
| Comparison of Two Different Distraction Methods Affecting the Level of Pain and Anxiety During Extracorporeal Shock Wave Lithotripsy[NCT02725281] | 120 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Effects of Music Therapy on Breastfeeding Rates Among Mothers of Premature Newborns[NCT00930761] | 101 participants (Actual) | Interventional | 2004-03-31 | Completed | |||
| Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
| Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy[NCT03007966] | Phase 2 | 60 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Randomized Trial Comparing Anchorsure® Suture Anchoring System and the CapioTM Slim Suture Capturing Device for Sacrospinous Ligament Suspension.[NCT03565640] | 48 participants (Actual) | Interventional | 2018-10-29 | Completed | |||
| Evaluation of Ultrasound-Guided Adductor Canal Blockade for Postoperative Analgesia Following Robotic Medial Unicompartmental Knee Replacement[NCT01818531] | Phase 4 | 150 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Combined Spinal Epidural Analgesia in Labour: A Comparison of Two Intrathecal Regimens of Single Shot Spinal[NCT03117595] | Phase 4 | 100 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| Comparative Study Between Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy[NCT05689242] | Phase 4 | 66 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | ||
| Topical Analgesia Before Inhalational Anaesthesia: A Retrospective Observational Study[NCT04959409] | 500 participants (Actual) | Observational | 2020-08-01 | Completed | |||
| Midazolam as an Adjuvant to Bupivacaine in Quadratus Lumborum Block After Caesarean Section; Does it Offer Better Pain Control? a Randomized Double Blind Clinical Trial[NCT05261672] | 60 participants (Anticipated) | Interventional | 2022-03-15 | Recruiting | |||
| Open-Label Study To Assess The Effect On Pain Control Of Durogesic (Fentanyl Transdermic Therapeutic System) Treatment In Subjects With Rheumatoid Arthritis Or Osteoarthritis Of The Knee Or Hip.[NCT00524160] | Phase 4 | 264 participants (Actual) | Interventional | 2001-07-31 | Completed | ||
| A Randomized Trial of the Impact of Three Labor Analgesia Techniques on Labor Duration in Spontaneously Laboring Nulliparous Parturients[NCT01982838] | 129 participants (Actual) | Interventional | 2010-07-31 | Terminated (stopped due to Low qualified candidate enrollment) | |||
| A Randomized Trial of the Impact of Three Labor Analgesia Techniques on Labor Duration in Nulliparous Labor Inductions[NCT01982851] | 134 participants (Actual) | Interventional | 2010-07-31 | Terminated (stopped due to low qualified candidate enrollment) | |||
| A Retrospective Case-controlled Study of the Association Between Request to Discontinue Second Stage Labor Epidural Analgesia and Risk of Instrumental Vaginal Delivery[NCT00443560] | 2,162 participants (Actual) | Observational | 2006-01-31 | Completed | |||
| Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for Maintenance of Labor Analgesia[NCT02949271] | Phase 4 | 179 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Early Compared With Late Neuraxial Analgesia in Nulliparous Labor Induction[NCT00380978] | 1,026 participants (Actual) | Interventional | 2001-10-31 | Completed | |||
| Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528] | 200 participants (Actual) | Interventional | 2019-04-17 | Completed | |||
| Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2006-02-28 | Recruiting | ||
| Pericapsular Nerve Group Block Versus Fascia Iliaca Block for Pre- and Post-Operative Analgesia in Elderly Patients With Hip Fracture[NCT04564326] | 51 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | |||
| Efficacy of Alfentanyl Versus Sufentanyl in Children for Pain During Treatment by Tracheal Suction in an Intensive Care Unit.[NCT01235637] | Phase 3 | 40 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain[NCT01946555] | 150 participants (Actual) | Observational | 2013-09-30 | Completed | |||
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures. Timmons Z MD, Feudale B MD Children Presenting to the ED With Distal Forearm Extremity Fractures Often Require Re-alignment Under Conscious Sedation. T[NCT03466242] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2018-05-01 | Not yet recruiting | ||
| Effects of Lavender Aromatherapy and Cold Application on Pain During Drain Removal[NCT04798040] | 121 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain[NCT04744883] | Early Phase 1 | 240 participants (Anticipated) | Interventional | 2020-08-10 | Recruiting | ||
| Randomized Controlled Trial of the Use of Intramuscular Fentanyl for the Incision and Drainage of Abscess in the Emergency Department[NCT01881997] | Phase 4 | 0 participants (Actual) | Interventional | 2011-06-30 | Withdrawn (stopped due to IRB modifications made study impractical.) | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| A Phase I Clinical Study Evaluating the Safety, Tolerability and Pharmacokinetics of HSK21542 in Healthy Volunteers[NCT04213196] | Phase 1 | 66 participants (Actual) | Interventional | 2020-01-09 | Completed | ||
| Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care[NCT02476981] | 75 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| A Randomised Control Trial to Determine Whether Intervention Based on a Microstream Capnography-based Ventilation Monitoring System Will Decrease Hypoxaemaia During Intravenous Sedation With Midazolam.[NCT01949012] | 190 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Tetracaine (Ametop®) Compared to Placebo for Reducing Pain Associated With Intramuscular Injection of Palivizumab (Synagis®) - A Pilot Study[NCT00484393] | Phase 4 | 7 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| Distraction in the Emergency Using Virtual Reality for Intravenous Needs in Children to Improve Comfort (DEVINCI): A Pilot Randomized Controlled Trial[NCT03750578] | 62 participants (Actual) | Interventional | 2018-12-17 | Completed | |||
| Morphine or Fentanyl for Refractory Dyspnea in COPD[NCT03834363] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-11-15 | Recruiting | ||
| Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy.[NCT04073173] | Phase 4 | 80 participants (Anticipated) | Interventional | 2020-11-01 | Not yet recruiting | ||
| Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia[NCT05898061] | 100 participants (Anticipated) | Observational [Patient Registry] | 2023-03-01 | Recruiting | |||
| Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-01 | Withdrawn (stopped due to Sponsoring staff have left institution) | ||
| Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Cholecystectomy, Is It a Promising Alternative Modality?[NCT05158270] | 90 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | |||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Effects of Chronic Musculoskeletal Pain and Opioidergic Versus Placebo Interventions on Neuroendocrine Function in Men[NCT00737737] | Phase 4 | 8 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057] | Phase 1 | 0 participants (Actual) | Interventional | 2018-09-30 | Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured) | ||
| A Study to Assess the Safety, Efficacy and Pharmacokinetics of Durogesic (Fentanyl Transdermal Drug Delivery System) in the Treatment of Pediatric Patients With Chronic Pain Requiring Long-term Opioid Therapy[NCT00271453] | Phase 3 | 41 participants (Actual) | Interventional | 1996-02-29 | Completed | ||
| Pain Control for Intrauterine Device Placement: A Randomized Controlled Trial of Paracervical Block[NCT02219308] | 67 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366] | Phase 4 | 121 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Pain Measurement in Healthy Volunteers[NCT00001597] | 40 participants | Observational | 1997-03-31 | Completed | |||
| Comparative Study of Magnesium Sulfate Versus Fentanyl as Adjuvants to Bupivacaine for Thoracic Epidural Analgesia in Multiple Traumatic Fracture Ribs[NCT03595397] | 60 participants (Anticipated) | Interventional | 2018-07-31 | Not yet recruiting | |||
| Non- Inferiority Study of Erector Spinae Plane Block Compared to Thoracic Epidural Analgesia in Multimodal Pain Management of Multiple Rib Fractures[NCT05069961] | 0 participants (Actual) | Interventional | 2023-05-31 | Withdrawn (stopped due to Study was closed with IRB as PI wants to design the protocol extensively.) | |||
| The Effect of Different Applications of Tourniquet on Total Knee Arthroplasty[NCT03256058] | 60 participants (Anticipated) | Interventional | 2017-08-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Number of Participants Administered Additional Pain Medications
After the procedure, research personnel will ask anesthetist what medications, if any, they gave outside of the study protocol (NCT04871425)
Timeframe: Immediately postoperatively
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine | 23 |
| Fentanyl | 30 |
Provider Satisfaction With Anesthesia Assessed by the VAS
After the procedure, research personnel will assess provider's satisfaction with patient's anesthesia on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: Immediately postoperatively
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | 90 |
| Fentanyl | 86.8 |
Satisfaction With Anesthesia Assessed by the ISAS
After the procedure, either at time of discharge (if less than 30 minutes) or at 30 minutes (if not yet discharged), research personnel will assess the participant's satisfaction with anesthesia using the Iowa Satisfaction with Anesthesia Scale. This is a validated perioperative anesthesia satisfaction scale with a minimum score of -3 and a maximum score of +3 with higher scores indicating higher satisfaction. (NCT04871425)
Timeframe: At discharge or 30 minutes after the procedure
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | 2.4 |
| Fentanyl | 2.2 |
Postoperative Pain Assessed by the VAS
Patients will complete 2 followup surveys asking about their postoperative pain after discharge. This will be assessed on a 100mm visual analog scale. The minimum score is 0mm and the maximum score if 100mm, with higher scores indicating higher pain levels. (NCT04871425)
Timeframe: 24 hours postoperatively and 7 days postoperatively
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Pain post-op day 1 | Pain post-op day 7 | |
| Fentanyl | 22 | 19.1 |
| Ketamine | 24.5 | 18.2 |
Satisfaction With Anesthesia (Iowa Satisfaction With Anesthesia Scale [ISAS])
The Iowa Satisfaction with Anesthesia Scale (ISAS) was given to women following a surgical abortion. The ISAS score is the mean of 11 responses to questions regarding satisfaction with anesthesia and has a score range of -3 (disagree strongly) to 3 (agree strongly). (NCT02755090)
Timeframe: Assessed 30 minutes after procedure completion.
| Intervention | units on a scale (Mean) |
|---|---|
| Nitrous Oxide and IV Saline | 0.7 |
| Standard Care Group (IV Sedation and Oxygen) | 1.8 |
Visual Analog Scale (VAS) Score for Maximum Procedural Pain
To compare women's maximum procedural pain measured on a visual analog scale (VAS) during a surgical abortion between 12 weeks 0 days to 16 weeks 0 days gestational age between women randomized to nitrous oxide versus intravenous sedation. A score of 0 represents no pain and a score of 100 represents pain as bad as it could be. (NCT02755090)
Timeframe: Assessed immediately following completion of the procedure (as defined as removal of the speculum)
| Intervention | units on a scale (Mean) |
|---|---|
| Nitrous Oxide and IV Saline | 54.1 |
| Standard Care Group (IV Sedation and Oxygen) | 34.0 |
Capnometry Value
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 36.6 |
| Fentanyl | 38.3 |
Capnometry Value
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 38.6 |
| Fentanyl | 40.4 |
Capnometry Value
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 38.7 |
| Fentanyl | 38.9 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 76.1 |
| Fentanyl | 73.4 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 76.3 |
| Fentanyl | 73.6 |
Diastolic Blood Pressure
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 70.8 |
| Fentanyl | 70.6 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -24.4 |
| Fentanyl | -25.3 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -30.6 |
| Fentanyl | -31.9 |
Difference From Baseline in Visual Analog Scale Pain Score
A VAS score is a self reported pain score of 0-100 millimeters (0 = no pain; 100 = worst possible pain). A decrease in a VAS score indicates a decrease in pain severity. (NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | score on a scale (Mean) |
|---|---|
| Ketamine | -27.7 |
| Fentanyl | -29.0 |
Heart Rate
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 90.1 |
| Fentanyl | 84.4 |
Heart Rate
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 90.5 |
| Fentanyl | 85.6 |
Heart Rate
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | beats per minute (Mean) |
|---|---|
| Ketamine | 85.1 |
| Fentanyl | 82.9 |
Oxygen Saturation
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.6 |
| Fentanyl | 99.2 |
Oxygen Saturation
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.5 |
| Fentanyl | 99.4 |
Oxygen Saturation
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | percent (Mean) |
|---|---|
| Ketamine | 99.3 |
| Fentanyl | 99.3 |
Respiratory Rate
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 23.1 |
| Fentanyl | 22.3 |
Respiratory Rate
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 23.3 |
| Fentanyl | 19.9 |
Respiratory Rate
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | breaths per minute (Mean) |
|---|---|
| Ketamine | 21.8 |
| Fentanyl | 19.7 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 15 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 127.3 |
| Fentanyl | 127.9 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 30 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 126.3 |
| Fentanyl | 123.4 |
Systolic Blood Pressure
(NCT02778880)
Timeframe: 60 minutes after study medication
| Intervention | mmHg (Mean) |
|---|---|
| Ketamine | 122.3 |
| Fentanyl | 122.0 |
Exploratory Outcome: Reduction in Age Appropriate Pain Scale Scores
Mean difference in the reduction of the pain scale scores at 20 minutes. Two commonly used, age appropriate and previously validated, pediatric pain assessment tools were used: FACES Pain Scale - Revised for children ages 4-10 and the Visual Analog Scale for children ages 11-17. The FACES Pain Scale - Revised is a self-reported measure of pain intensity developed for children with pain intensity represented by images of grimacing faces on a scale of 0 (no pain) to 10 (maximum pain). The Visual Analog Scale is a self-reported measure of pain intensity where patients mark their pain level on a 10 cm line that represents a continuum of no pain at 0 cm and worst pain at 10 cm. For analysis, pain scale data were merged and reported as values form 0 to 100. The minimum clinically significant reduction in pain was defined as a decrease of 20. (NCT02521415)
Timeframe: 20 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 44 |
| Fentanyl | 35 |
Secondary Outcome: Total Dose of Opioid Pain Medication in Morphine Equivalents/kg/Hour
Compare the total dose of opioid pain medication in morphine equivalents/kg/hour required during the ED evaluation of children with suspected forearm fractures after randomization and treatment with IN ketamine or IN fentanyl. (NCT02521415)
Timeframe: participants will be followed during the emergency department length of stay, estimated to average 6 hours
| Intervention | morphine equivalents/kg/hr (Median) |
|---|---|
| Ketamine | 0.04 |
| Fentanyl | 0.05 |
NRS Pain Score After Blunt Dissection
Patient reported NRS pain scores after Blunt Dissection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.1 |
| Placebo | 4.4 |
NRS Pain Score After Irrigation
Patient reported NRS pain scores after Irrigation. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.4 |
| Placebo | 2.6 |
NRS Pain Score After Lidocaine Injection
Patient reported NRS pain scores after Lidocaine injection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Following Lidocaine injection measured once anytime up to 12 minutes after intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.4 |
| Placebo | 8.0 |
NRS Pain Score After Packing of Abscess
Patient reported pain after Packing of abscess. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once at the time of completion of application of the bandage, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.5 |
| Placebo | 3.9 |
NRS Pain Score Following Incision
Patient reported NRS pain scores following Incision. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.9 |
| Placebo | 3.9 |
Numerical Rating Scale (NRS) Pain Score at Baseline
Patient reported pain scores at baseline. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.3 |
| Placebo | 8.1 |
Numerical Rating Scale (NRS) Pain Score for Overall Procedure
Patient reported pain scores for overall Procedure assessed immediately after placement of dressing at the end of procedure. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once following placement of dressing at completion of procedure, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 6.2 |
| Placebo | 7.0 |
Adverse Events at 30 Minutes
The patient were asked at 30 minutes post administration of analgesia if they experienced any side effects like nausea, vomiting, headache etc. (NCT02388321)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine | 0 |
| Fentanyl | 0 |
Pain Score at 30 Minutes
An 11 point Likert Visual Analog Scale with 0 being no pain, 5 being moderate pain and 10 being very severe pain was verbally administered to the patient at 30 minutes post administration of analgesia. (NCT02388321)
Timeframe: 30 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine | 3.36 |
| Fentanyl | 2.09 |
Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia Quality Recovery Scale Score
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
Average Total Propofol Consumption Per Group
Total propofol consumption per subject was measured as μg/kg/min of procedure in minutes. The average propofol consumption in each group will be measured as secondary outcome. (NCT03139279)
Timeframe: between 7 and 57 minutes (median 19 min)
| Intervention | μg/kg/min (Median) |
|---|---|
| Dexmedetomidine and Propofol | 140 |
| Saline Placebo and Propofol | 180 |
Lowest Intraoperative % Change in MAP From Baseline
Lowest intraoperative percent (%) change in mean arterial pressure (MAP) from baseline (average in each group) (NCT03139279)
Timeframe: 30 minutes
| Intervention | percentage change (Mean) |
|---|---|
| Dexmedetomidine and Propofol | 30 |
| Saline Placebo and Propofol | 21 |
Number of Participants With Apneic Episodes Intraoperatively Requiring Positive Pressure Ventilation
Incidence of apneic episodes intraoperatively requiring positive pressure ventilation in each group (NCT03139279)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine and Propofol | 0 |
| Saline Placebo and Propofol | 0 |
Percentage of Subjects Ready for Discharge in Each Group at 30 Minutes Post Procedure
Each subject was assessed for readiness for discharge at 10, 20 and 30 minutes after the procedure, using the Modified Post-Anesthesia Discharge Scoring System (MPADSS). A subject getting an MPADS score of 9-10 is deemed ready for discharge. The percentage of subjects ready for discharge in each group at 10, 20 and 30 minutes will be measured as primary outcome. (NCT03139279)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine and Propofol | 26 |
| Saline Placebo and Propofol | 44 |
Evaluate the Long-term Safety and Effectiveness of EN3267
(NCT00263575)
Timeframe: screening, 2 week titration period and 12 monthly study visits
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Patients with at least 1 AE | Patients with at least 1 AE causing discontinue | Patients with at least 1 SAE | Patients with an AE resulting in death | |
| Maintenance | 87 | 23 | 40 | 15 |
| Overall | 116 | 37 | 46 | 19 |
| Titration | 64 | 14 | 7 | 4 |
Mean Change in Numeric Pain Score (NPS) From First to Last Dose
"Mean difference in the numeric pain score (NPS) from the first dose to the final dose of medication administered.~A significant mean pain score change is defined as greater than or equal to 2~Numeric Pain Score (NPS) 0-10, 0 Least pain, 10 most pain" (NCT00580489)
Timeframe: Medication was administered over a mean transport time of 37 minutes in the Morphine group and 43 minutes in the Fentanyl group.
| Intervention | score on a scale (Mean) |
|---|---|
| Morphine | 2.2 |
| Fentanyl | 2.5 |
Recording of Instance of Narcotic Side Effects.
Instances of narcotic side effects (vital sign derangement, itching, nausea/vomiting) . (NCT00580489)
Timeframe: Groups were observed a mean of 37 minutes in the Morphine Group and a mean of 43 minutes in the Fentanyl group for side effects.
| Intervention | participants (Number) |
|---|---|
| Arm C Morphine | 0 |
| Arm D Fentanyl | 0 |
Summed Pain Intensity Differences (SPID) at 30 Minutes After Dosing (SPID30)
"Pain intensity was assessed by the participant using a 0-100 mm visual analog scale where 0 represented no pain and 100 represented worst possible pain at 0 (baseline, beginning of the pain episode), 5, 10, 15, and 30 minutes after each dose of study medication during each breakthrough pain episode. The pain intensity difference was defined as the difference in pain intensity at the various time points versus time 0 (baseline). SPID30 was calculated as the time-weighted sum of the PID scores using the following formula: SPID30=(5*PID5)+(5*PID10)+(5*PID15)+(15*PID30). The minimum and maximum SPID30 scores were -3000 and 3000. A higher score indicates less pain." (NCT00538850)
Timeframe: Baseline (time 0, beginning of each pain episode) through 30 minutes after dosing for each pain episode
| Intervention | Units on a scale (Mean) |
|---|---|
| Fentanyl Sublingual Spray | 640.3 |
| Placebo | 399.6 |
Global Evaluation of the Study Medication at 30 and 60 Minutes After Dosing
Global evaluation of the study medication was assessed by the participant on a 5-point scale (1=Poor, 2=Fair, 3=Good, 4=Very good, 5=Excellent) at 30 and 60 minutes after each dose of study medication during each breakthrough pain episode. A higher score indicates a better evaluation. (NCT00538850)
Timeframe: 30 through 60 minutes after dosing for each pain episode
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| 30 minutes | 60 minutes | |
| Fentanyl Sublingual Spray | 2.8 | 3.1 |
| Placebo | 2.0 | 2.2 |
Summed Pain Intensity Differences (SPID) at 5, 10, 15, 45, and 60 Minutes After Dosing
"Pain intensity was assessed by the participant using a 0-100 mm visual analog scale where 0 represented no pain and 100 represented worst possible pain at 0 (baseline, beginning of the pain episode), 5, 10, 15, 30, 45 and 60 minutes after each dose of study medication during each breakthrough pain episode. The pain intensity difference was defined as the difference in pain intensity at the various time points versus time 0 (baseline). SPID was calculated as the time-weighted sum of the PID scores using the following formulas: SPID5=(5*PID5), SPID10=(5*PID5)+(5*PID10), SPID15=(5*PID5)+(5*PID10)+(5*PID15), SPID30=(5*PID5)+(5*PID10)+(5*PID15)+(15*PID30), SPID45=(5*PID5)+(5*PID10)+(5*PID15)+(15*PID30)+(15*PID45), SPID60=(5*PID5)+(5*PID10)+(5*PID15)+(15*PID30) +(15*PID45) +(15*PID60). The minimum and maximum SPID scores were -500 to 500, -1000 to 1000, -1500 to 1500, -3000 to 3000, -4500 to 4500, and -6000 to 6000, respectively. A higher score indicates less pain." (NCT00538850)
Timeframe: Baseline (time 0, beginning of each pain episode) through 60 minutes after dosing for each pain episode
| Intervention | Units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| SPID5 | SPID10 | SPID15 | SPID45 | SPID60 | |
| Fentanyl Sublingual Spray | 40.3 | 115.0 | 220.6 | 1122.0 | 1649.0 |
| Placebo | 32.0 | 81.1 | 150.3 | 667.0 | 965.7 |
Total Pain Relief (TOTPAR) at 5, 10, 15, 30, 45, and 60 Minutes After Dosing
Pain relief (PAR) was assessed by the participant on a 5-point scale (1=No relief, 2=A little relief, 3=Moderate relief, 4=A lot of relief, 5=Complete relief) at 5, 10, 15, 30, 45 and 60 minutes after each dose of study medication during each breakthrough pain episode. TOTPAR was calculated as the time-weighted sum of the PAR scores at each time point using the following formulas: TOTPAR5=(5*PAR5), TOTPAR10=(5*PAR5)+(5*PAR10), TOTPAR15=(5*PAR5)+(5*PAR10)+(5*PAR15), TOTPAR30=(5*PAR5)+(5*PAR10)+(5*PAR15)+(15*PAR30), TOTPAR45=(5*PAR5)+(5*PAR10)+(5*PAR15)+(15*PAR30)+(15*PAR45), TOTPAR60=(5*PAR5)+(5*PAR10)+(5*PAR15)+(15*PAR30) +(15*PAR45) +(15*PAR60). The minimum and maximum TOTPAR5, TOTPAR10, TOTPAR15, TOTPAR30, TOTPAR45, and TOTPAR60 scores were 5 to 25, 10 to 50, 15 to 75, 30 to 150, 45 to 225, and 60 to 300, respectively. A higher score indicates more pain relief. (NCT00538850)
Timeframe: 5 through 60 minutes after dosing for each pain episode
| Intervention | Units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| TOTPAR5 | TOTPAR10 | TOTPAR15 | TOTPAR30 | TOTPAR45 | TOTPAR60 | |
| Fentanyl Sublingual Spray | 8.6 | 19.7 | 32.9 | 78.3 | 126.3 | 176.4 |
| Placebo | 7.6 | 16.7 | 27.1 | 61.0 | 95.5 | 131.2 |
Circulating Leukemia Cells in Peripheral Blood Change From Prior to the Methotrexate Infusion to Three Days After Between Two Arms (4 Hours vs. 24 Hours)
"White blood cell (leukocytes) counts in peripheral blood by Complete Blood Count~Measurement: Percentage change of leukemia cells from baseline" (NCT00137111)
Timeframe: Immediately before the methotrexate infusion and three days after subsequent infusion
| Intervention | Percent change (Mean) |
|---|---|
| 4 hr | -44 |
| 24 hr | -50 |
Continuous Complete Remission Since Week 56 Therapy.
CCR was measured from end of week 56 therapy to the date of first treatment failure of any kind (relapse, death, lineage switch, or second malignancy) or to the last date of follow-up. Measurement was determined by Kaplan-Meyer estimate. (NCT00137111)
Timeframe: Median follow up time (range) 4.5 (1 to 7.8) years
| Intervention | Percentage of participants (Number) |
|---|---|
| Patients With High Risk of CNS Relapse | 92.2 |
Mean Difference of Active Methotrexate Polyglutamates (MTXPG) in Leukemia Cells Between Two Arms (4 Hours vs. 24 Hours).
Children were randomly assigned to receive initial single-agent treatment with HDMTX (1g/m^2) as either a 24-hour infusion or a 4-hour infusion and the outcome measure was the accumulation of MTXPG in leukemia cells. (NCT00137111)
Timeframe: 42 hours after start of high dose methotrexate infusion (HDMTX)
| Intervention | pmol/1,000,000,000 cells (Mean) |
|---|---|
| 4 hr | 1688 |
| 24 hr | 2521 |
Overall Event-free Survival (EFS)
EFS was measured from the start of on-study to the date of first treatment failure of any kind (relapse, death, lineage switch, or second malignancy) or to the last date of follow-up. Failure to enter remission was considered an event at time zero. Measurement was determined by Kaplan-Meyer estimate. (NCT00137111)
Timeframe: Median follow-up time (range) 5.6 (1.3 to 8.9) years
| Intervention | Percentage of Participants (Number) |
|---|---|
| Total Therapy | 87.3 |
Median Difference in CASP1 Gene Expression in Primary Leukemia Cells of Patients in Glucocorticoid-resistant Cells vs Glucocorticoid-sensitive Cells
Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of CASP1 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray. (NCT00137111)
Timeframe: Pre-treatment
| Intervention | arbitrary units (Median) | |
|---|---|---|
| Prednisolone-sensitive cells | Prednisolone-resistant cells | |
| Total Therapy | 341.3 | 447.9 |
Median Difference in NLRP3 Gene Expression in Primary Leukemia Cells of Patients in Glucocorticoid-resistant Cells vs. Glucocorticoid-sensitive Cells
Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of NLRP3 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray. (NCT00137111)
Timeframe: Pre-treatment
| Intervention | arbitrary units (Median) | |
|---|---|---|
| Prednisolone-sensitive cells | Prednisolone-resistant cells | |
| Total Therapy | 41.2 | 110.7 |
Minimal Residual Disease (MRD)
Detection of MRD at end of induction where positive MRD was defined as one or more leukemic cell per 10,000 mononuclear bone-marrow cells (>=0.01%). (NCT00137111)
Timeframe: End of Induction (Day 46 MRD measurement)
| Intervention | participants (Number) | |
|---|---|---|
| Negative <0.01% | Positive >= 0.01% | |
| Total Therapy | 390 | 102 |
"Perceived Intervention Effectiveness Was Assessed With a VAS (0 = Not Effective at All; 10 = Most Effective Imaginable) for Each Intervention Session."
(NCT04034004)
Timeframe: Delivered after completion of each of the 4 meditation intervention sessions. Up to 8 weeks.
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| intervention 1 effectiveness | intervention 2 effectiveness | intervention 3 effectiveness | intervention 4 effectiveness | |
| Mindfulness Meditation | 4.83 | 4.05 | 4.21 | 4.51 |
| Non-mindfulness Meditation | 5.13 | 5.17 | 5.21 | 5.40 |
Brief Pain Inventory (BPI)
Pain severity and interference: impact of pain on daily function, location of pain, pain medications and amount of pain relief in the past 24 hours or the past week. Higher scores indicate higher chronic pain. BPI severity and interference scales are used and collected before and after each intervention. Higher BPI severity indicate higher chronic pain severity. Higher BPI interference scores indicate higher chronic pain interference.The scoring scale for severity and interference range from 0 - 10, respectively. (NCT04034004)
Timeframe: Administered at the baseline, post-intervention session 6 and post-intervention session 7. Outcome measurements will compare in BPI severity and interference from baseline to session 7.
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| baseline BPI severity | session 7 BPI severity | baseline BPI interference | session 7 BPI interference | |
| Mindfulness Meditation | 4.47 | 3.94 | 4.40 | 3.38 |
| Non-mindfulness Meditation | 5.22 | 5.15 | 5.17 | 4.57 |
Pain Catastrophizing Scale
This is a 13-item questionnaire with 3 subscales assessing rumination, magnification, and helplessness in patients. A numeric value between 0 (not at all) and 4 (all the time) is provided in response to each statement. Scores on this assessment range from 0 to 52, with higher values reflecting more salient impacts of pain on one's day to day experience. The total range is from 0 - 52. (NCT04034004)
Timeframe: The Pain Catastrophizing Scale was administered at the baseline, post-intervention session 6 and session 7. Outcome measurements will compare change in Pain Catastrophizing Scale from baseline to session 7.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline PCS | Session 7 PCS | |
| Mindfulness Meditation | 18.57 | 15.33 |
| Non-mindfulness Meditation | 20.83 | 18.48 |
Pain Ratings
"Numerical pain ratings (NRS) will be assessed while lying on the back and in response to the straight leg raise test (SLR). Pain ratings will be collected during SLR 1 and SLR 2 in the baseline, saline and naloxone sessions, respectively. The 11 point scan will include a minimum rating of 0 which is characterized as no pain whereas the maximum (10) is labeled as most intense imaginable. Higher numbers correspond to higher pain." (NCT04034004)
Timeframe: Pain ratings were collected while lying supine and in response to the straight leg raise test. Collected twice, once in the first half and one in the second half of the baseline, saline infusion and naloxone infusion sessions. Up to 8 weeks total.
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline session: supine 1 | baseline session: straight leg raise test 1 | baseline session: supine 2 | baseline session: straight leg raise test 2 | saline session: supine 1 | saline session: straight leg raise test 1 | saline session: supine 2 | saline session: straight leg raise 2 | naloxone session: supine 1 | naloxone session: straight leg raise 1 | naloxone session: supine 2 | naloxone session: straight leg raise 2 | |
| Mindfulness Meditation | 3.60 | 4.83 | 4.13 | 5.15 | 3.23 | 4.37 | 3.90 | 3.67 | 3.30 | 4.30 | 3.73 | 3.45 |
| Non Mindfulness Meditation | 4.69 | 5.41 | 4.76 | 5.78 | 4.62 | 5.75 | 4.37 | 5.32 | 4.82 | 6.10 | 5.18 | 5.52 |
SF-12 Health Survey (SF-12) Physical Functioning
This is a 12-item version of the SF-12 item Health Survey designed to assess general mental and physical functioning, and overall health-related quality of life. We used the physical functioning SF-12 scale and collected this information before and after each intervention and by group. The total range of scores is from 0 - 100. The minimum total score is 0 and the maximum score is 100. Higher scores indicate better functioning. (NCT04034004)
Timeframe: Up to 8 weeks. Administered at visit 1, 6 and 7. Outcome measurements will compare SF-12 health survey from baseline to session 7.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| baseline SF physical functioning | session 7 SF physical functioning | |
| Mindfulness Meditation | 52.50 | 39.66 |
| Non-mindfulness Meditation | 49.17 | 44.83 |
The Roland-Morris Disability Questionnaire (RMDQ)
The Roland-Morris Questionnaire (RMDQ) is a self-administered disability measure in which greater levels of disability are reflected by higher numbers on a 24-point scale. The RMDQ has been shown to yield reliable measurements, which are valid for inferring the level of disability, and to be sensitive to change over time for groups of patients with low back pain. Higher scores indicate greater disability. Total RMDQ scores are used before and after each intervention by group. The range of scores is from 0 - 24. (NCT04034004)
Timeframe: The Roland-Morris Disability Questionnaire was administered at the baseline, post-intervention session 6 and session 7. Outcome measurements will compare RMDQ from baseline to session 7.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| baseline RMDQ | session 7 RMDQ | |
| Mindfulness Meditation | 12.86 | 12.03 |
| Non-mindfulness Meditation | 13.85 | 14.02 |
Maternal Breastfeeding 7-15 Days After Discharge
Maternal breastfeeding means: exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At the first follow-up visit (7-15 days after discharge)
| Intervention | participants (Number) |
|---|---|
| Control | 32 |
| Music Therapy | 42 |
Maternal Breastfeeding at 30 Days After Discharge
Maternal breastfeeding means exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At 30 days after the infant hospital discharge
| Intervention | participants (Number) |
|---|---|
| Control | 30 |
| Music Therapy | 38 |
Maternal Breastfeeding at 60 Days After Discharge
Maternal breastfeeding means exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At 60 days after the infant hospital discharge
| Intervention | participants (Number) |
|---|---|
| Control | 27 |
| Music Therapy | 36 |
Maternal Breastfeeding at Infant Discharge
Maternal breastfeeding means exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At the time of the infant hospital discharge
| Intervention | participants (Number) |
|---|---|
| Control | 33 |
| Music Therapy | 42 |
Number of Participants With Presence of Opioid Related Side Effects--Itching
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 2 |
| Quadratus Lumborum Block | 3 |
Number of Participants With Presence of Opioid Related Side Effects--Itching
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 0 |
| Quadratus Lumborum Block | 4 |
Number of Participants With Presence of Opioid Related Side Effects--Nausea
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 6 |
| Quadratus Lumborum Block | 3 |
Number of Participants With Presence of Opioid Related Side Effects--Nausea
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 9 |
| Quadratus Lumborum Block | 5 |
Number of Participants With Presence of Opioid Related Side Effects--Vomiting
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2 |
Number of Participants With Presence of Opioid Related Side Effects--Vomiting
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 3 |
Post-operative Verbal Pain Score at Rest
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2.7 |
Post-operative Verbal Pain Score at Rest
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3.6 |
| Quadratus Lumborum Block | 3.3 |
Post-operative Verbal Pain Score With Activity
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 4.9 |
| Quadratus Lumborum Block | 5.3 |
Post-operative Verbal Pain Score With Movement
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome. (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 5.10 |
| Quadratus Lumborum Block | 5.03 |
Time to First Oral Analgesic
When does the patient require their first post operative analgesic dose? (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | minutes (Median) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 141 |
| Quadratus Lumborum Block | 91 |
Total Opioid Consumption
Total opioids consumed during the first 24hrs post operatively. Measured as 24hr Oxycodone Equivalent (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | milligrams (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 19.7 |
| Quadratus Lumborum Block | 25.2 |
Change in Pelvic Flore Disability Index - 20 (PFDI-20) Scores From Baseline to 12 Months
"Symptomatic success was assessed by the pelvic floor disability index (PFDI-20) questionnaire. The PFDI-20 has 20 items within 3 sub-scales of symptoms (total of 20 items). Each item produces a response of 0 to 4, the average response in each sub-scale is multiplied by 25 to obtain the sub-scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) |
|---|---|
| Capio Slim Device | -66.3 |
| Anchorsure Device | -71.0 |
Change in Symptomatic Success - PFIQ-7 Scores
"Symptomatic success will be assessed by the Pelvic Floor Impact Questionnaire - 7 (PFIQ-7). The PFIQ-7 has 7 items for each of 3 sub-scales (total of 21 items). Each item produces a response of 0 to 3, the average response in each sub-scale is multiplied by 100/3 to obtain the total scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) |
|---|---|
| Capio Slim Device | -26.4 |
| Anchorsure Device | -40.6 |
POP-Q Stage Score
The stage is assigned as follows: 0 if there is no prolapse at all, 1 if there is prolapse but the leading point is not within 1cm of the hymen, 2 if the leading point is within 1 cm of the hymen (from 1cm within the hymen to 1cm beyond the hymen), 3 if the leading point is more than 1cm from the hymen but less than 2cm from being completely prolapsed, and 4 if the leading point is within 2cm of being complete prolapsed. Therefore higher POP-Q stages correlate to a worse degree of prolapse than lower POP-Q stages. (NCT03565640)
Timeframe: at 12 MONTHS
| Intervention | Units on a scale (Mean) |
|---|---|
| Capio Slim Device | 0.8 |
| Anchorsure Device | 0.9 |
Change in Buttock and Posterior Thigh Pain
This will be assessed using the numeric rating scale (NRS). The score is 0-10, with higher scores denoting a greater degree of pain. (NCT03565640)
Timeframe: postoperative 12 month
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Sacrospinous ligament fixation site Pain compared to preop | Worst pain compared to preop | |
| Anchorsure Device | -0.2 | -1.5 |
| Capio Slim Device | -0.5 | -1.8 |
Quadriceps Motor Strength
Comparison of quadriceps motor strength at 6 hour post nerve block between two groups: adductor canal block and lumbar plexus block. The score range is 0-5, with higher scores denoting better outcomes. (NCT01818531)
Timeframe: 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Adductor Canal Block | 4 |
| Lumbar Plexus Block | 2.5 |
Time to First Analgesic
Time to first analgesic between two groups: adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Adductor Canal Block | 601 |
| Lumbar Plexus Block | 659 |
Opioid Consumption
Comparison of cumulative opioid consumption over 24 hour period between adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 6, 12, 18, and 24 hours
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| 6 hours | 12 hours | 18 hours | 24 hours | |
| Adductor Canal Block | 1.5 | 11 | 20.9 | 27.9 |
| Lumbar Plexus Block | 2.5 | 10.3 | 20.7 | 32.1 |
Opioid Related Side Effects
Occurrence of opioid related side effects (nausea, vomiting and pruritus) between two groups: adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 6, 12, 18, and 24 hours
| Intervention | events (Number) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea 6 hours | Nausea 12 hours | Nausea 18 hours | Nausea 24 hours | Vomiting 6 hours | Vomiting 12 hours | Vomiting 18 hours | Vomiting 24 hours | Pruritus 6 hours | Pruritus 12 hours | Pruritus 18 hours | Pruritus 24 hours | |
| Adductor Canal Block | 14 | 10 | 5 | 9 | 6 | 6 | 2 | 4 | 11 | 7 | 5 | 10 |
| Lumbar Plexus Block | 15 | 16 | 8 | 15 | 8 | 6 | 3 | 6 | 3 | 4 | 5 | 13 |
Verbal Pain Scores at 6 Hours Post Nerve Blockade.
Comparison of verbal numerical pain scores at rest and with movement 6 hours following nerve blockade. The score range is 0-10 with higher scores denoting worse outcomes. (NCT01818531)
Timeframe: 6 hours post block.
| Intervention | score on a scale (Mean) | |
|---|---|---|
| rest | movement | |
| Adductor Canal Block | 1 | 1.6 |
| Lumbar Plexus Block | 1.1 | 1.5 |
Duration of Labor Analgesia
Time in minutes from initiation of labor analgesia until delivery of the infant (NCT00443560)
Timeframe: Time form initiation of labor analgesia to delivery (up to 24 hours)
| Intervention | minutes (Median) |
|---|---|
| Instrumental Vaginal Delivery (IVD) | 420 |
| Spontaneous Vaginal Delivery (SVD) | 300 |
Number of Parturients With a Decrease in the Infusion of Epidural Analgesia During Second Stage of Labor
At the request of the obstetric provider, second stage analgesia density was decreased by decreasing the basal infusion rate if there was dissatisfaction with the progress of labor or a perceived inability to push. The basal infusion was never totally discontinued. (NCT00443560)
Timeframe: Second stage of labor up to 3 hours
| Intervention | participants (Number) |
|---|---|
| Instrumental Vaginal Delivery (IVD) | 146 |
| Spontaneous Vaginal Delivery (SVD) | 51 |
Number of Participants With Breakthrough Pain in the First Stage of Labor
Pain not responding to epidural analgesia in the first stage of labor was treated with bolus dose of bupivacaine 1.25 mg/mL or lidocaine 10 mg/mL, 10 to 15 mL. If pain relief was obtained the infusion concentration was increased. If the patient had no pain relief following the bolus injection, the epidural catheter was replaced. (NCT00443560)
Timeframe: Supplemental analgesia in first stage of labor (<24 hours)
| Intervention | participants (Number) | ||
|---|---|---|---|
| Supplemental bolus | Infusion increase | Concentration increase | |
| Instrumental Vaginal Delivery (IVD) | 802 | 149 | 32 |
| Spontaneous Vaginal Delivery (SVD) | 243 | 87 | 19 |
Duration of Second Stage of Labor
(NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | minutes (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 44 |
| Continuous Epidural Infusion | 63 |
Maximum Reported Labor Pain Score
Measured using a verbal analog pain scale of 1-10, where 0=no pain and 10=worst possible pain. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | score on a scale (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 3 |
| Continuous Epidural Infusion | 2 |
Number of Patient Controlled Epidural Analgesia (PCEA) Attempts
Determined by the number of times subject activates the PCEA pump (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | attempts (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 0.75 |
| Continuous Epidural Infusion | 0.63 |
Number of Subjects Experiencing Hypotension Requiring Vasopressor Treatment
Number of patients who needed a vasopressor medication to treat a drop in blood pressure (NCT02949271)
Timeframe: duration of labor, up to 24 hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Programmed Intermittent Epidural Bolus | 8 |
| Continuous Epidural Infusion | 3 |
Ratio of Patient Controlled Epidural Analgesia (PCEA) Successful Attempts to Unsuccessful Attempts
Ratio generated by the number of times subjects activates PCEA and receives additional anesthetic compared with times subject activates PCEA and does not receive additional anesthetic. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | ratio of attempts (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 0.17 |
| Continuous Epidural Infusion | 0.12 |
Volume of Local Anesthetic Received Through Patient Controlled Epidural Analgesia (PCEA) Per Hour
The volume of local anesthetic that the patient received through activation of the patient-controlled epidural analgesia system per hour. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | milliliters per hour (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 4.03 |
| Continuous Epidural Infusion | 4.52 |
Volume of Local Anesthetic Required Per Hour
The total volume of local anesthetic that the patient received from the CAPP pump per hour. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | milliliters per hour (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 11.49 |
| Continuous Epidural Infusion | 12.38 |
Degree of Motor Blockade Measured as Lowest Recorded Modified Bromage Score
The Modified Bromage Score ranges from 1-5. 1 = complete block, 2 = almost complete block, 3 = partial block, 4 = detectable weakness of hip flexion, and 5 = no detectable weakness of hip flexion while supine. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Score of 5 | Score of 4 | Score of 3 | Score of 2 | Score of 1 | |
| Continuous Epidural Infusion | 26 | 20 | 3 | 2 | 1 |
| Programmed Intermittent Epidural Bolus | 37 | 9 | 4 | 1 | 0 |
Number of Subjects Who Were Satisfied With Procedure
"Determined using a 5-point scale where 1=very dissatisfied, 2=dissatisfied, 3=neutral, 4=satisfied, 5=very satisfied. Subjects were considered satisfied if selected very satisfied or satisfied on the patient questionnaire." (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Very satisfied | Satisfied | |
| Continuous Epidural Infusion | 39 | 3 |
| Programmed Intermittent Epidural Bolus | 35 | 9 |
Total Number of Subjects Experiencing Each Mode of Delivery
Modes of delivery: spontaneous vaginal delivery (SVD), assisted vaginal delivery (AVD), and caesarean delivery (CD) (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| SVD | AVD | CD | |
| Continuous Epidural Infusion | 37 | 5 | 17 |
| Programmed Intermittent Epidural Bolus | 41 | 5 | 15 |
Analgesia Efficacy
Patients were asked to rate their average pain score using an 11-point verbal rating score (VRS)for pain (0 - 10: 0= no pain, 10= worst pain imaginable) between 1st and 2nd analgesia request. (NCT00380978)
Timeframe: At first and second analgesia requests
| Intervention | Scores on a scale (Median) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 1 |
| Systemic Analgesia | 5 |
Delivered by Cesarean Section
The decision to proceed to operative delivery was made by the obstetric team for maternal or fetal indications. (NCT00380978)
Timeframe: Time form initiation of labor analgesia to delivery (up to 24 hours)
| Intervention | participants (Number) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 134 |
| Systemic Analgesia | 126 |
Duration of Labor
Labor was induced by initiating an oxytocin infusion or by infusing extra-amniotic saline followed by oxytocin. All participants had continuous external electronic fetal heart rate (FHR) monitoring and tocodynamometry. Internal fetal scalp electrodes were placed when the external tracing was not interpretable, and intrauterine pressure catheters were used to measure the intensity of contractions when deemed necessary by the obstetricians. Artificial rupture of membranes was performed, and nurses titrated oxytocin infusions according to institutional protocol. (NCT00380978)
Timeframe: Initiation of induction of labor to time of delivery
| Intervention | minutes (Median) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 528 |
| Systemic Analgesia | 569 |
Instrumented Vaginal Delivery
The decision to proceed to assisted/instrumental delivery was made by the obstetric team for maternal or fetal indications. (NCT00380978)
Timeframe: At time of decision for delivery
| Intervention | participants (Number) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 57 |
| Systemic Analgesia | 59 |
Neonatal Outcome (APGAR Score < 7 at 5 Minutes)
Infant's Apgar scores measured at 5 minutes of life and were assigned by nurses and pediatricians responsible for neonatal assessment. The Apgar score is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing the five values. The categories are skin color, pulse, reflex to stimulation, muscle tome, and breathing. The test was done at one and five minutes after birth, and may be repeated later if the score is and remains low. Scores 3 and below are generally regarded as critically low, 4 to 6 fairly low, and 7 to 10 generally normal. (NCT00380978)
Timeframe: APGAR score at 5 minutes
| Intervention | participants (Number) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 14 |
| Systemic Analgesia | 6 |
Vomiting
Vomiting during labor analgesia (NCT00380978)
Timeframe: Vomiting at second analgesia request
| Intervention | participants (Number) |
|---|---|
| Early Analgesia:Combined-spinal Epidural | 12 |
| Systemic Analgesia | 61 |
Indication for Cesarean Delivery
The decision to proceed to operative delivery was made by the obstetric team for maternal or fetal indications. (NCT00380978)
Timeframe: At time of decision for delivery
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Arrested dilation | Arrested descent | Non-reassuring fetal status | Other | |
| Early Analgesia:Combined-spinal Epidural | 85 | 18 | 27 | 4 |
| Systemic Analgesia | 83 | 23 | 16 | 4 |
Nausea
Participants were asked to rate their nausea (as none, mild, moderate, or severe) and report the presence or absence of vomiting. (NCT00380978)
Timeframe: At second analgesia request
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| None | Mild | Moderate | Severe | |
| Early Analgesia:Combined-spinal Epidural | 372 | 25 | 5 | 2 |
| Systemic Analgesia | 265 | 69 | 49 | 16 |
To Determine if a Difference in Pain Scale Ratings is Detectable Following Intramuscular Palivizumab Injection That Was Pre-treated With Placebo or Tetracaine.
Parent score 1-10 (1 representing no pain and 10 representing extreme pain) FLACC (Face, Legs, Activity, Cry, Consolability) Score 0-10 (at baseline and post injection) (0 representing no pain and 10 representing extreme pain) Change in FLACC score (NCT00484393)
Timeframe: 2 visits, 1 month apart
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Parent score | FLACC at baseline | FLACC post injection | Change in FLACC | |
| Placebo | 7.3 | 1.6 | 9.3 | 7.7 |
| Tetracaine | 7.3 | 1.7 | 8.4 | 6.7 |
Is Chronic Opioid Treatment Associated With Changes in Adrenocorticotropic Hormone (ACTH), Cortisol, Luteinizing Hormone (LH) and Testosterone Secretion?
(NCT00737737)
Timeframe: 4 weeks
| Intervention | ng/ml (Number) |
|---|---|
| Opioid | NA |
| Placebo | NA |
Is Placebo Analgesia Associated With a Similar Hormonal Response as Elicited by an Opioid Analgesic?
(NCT00737737)
Timeframe: 4 weeks
| Intervention | ng/ml (Number) |
|---|---|
| Opioid | NA |
| Placebo | NA |
Pain With Intrauterine Device (IUD) Placement
Distance (mm) from the left of the 100-mm visual analog scale (reflecting magnitude of pain) recorded at time of IUD Placement. Scale range is from 0mm (no pain) to 100mm (worst pain possible). A lower score (less pain) is considered a better outcome. (NCT02219308)
Timeframe: Moment of IUD insertion
| Intervention | mm (Median) |
|---|---|
| No Paracervical Block (Sham PCB) | 54 |
| Paracervical Block (PCB) | 33 |
Median Pain Scores for All Time Points
Distance (mm) from the left of the 100-mm visual analog scale of pain at various time points. Scale range is 0mm (no pain) to 100mm (worst pain possible). Lower scores are considered better outcomes. (NCT02219308)
Timeframe: Anticipation of procedure through 5 minutes after IUD placement
| Intervention | mm (Median) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Anticipated Pain | Baseline Pain | Speculum Insertion | Capped Needle or PCB | Tenaculum placement | Uterine Sounding | IUD placement | 5 mins after IUD placement | Overall pain | |
| No Paracervical Block (Sham PCB) | 51 | 0 | 6 | 8 | 10 | 47 | 54 | 27 | 51 |
| Paracervical Block (PCB) | 58 | 0 | 10 | 30 | 15 | 30 | 33 | 12 | 30 |
Reviews
145 reviews available for fentanyl and Pain
| Article | Year |
|---|---|
Sedoanalgesia with intravenous midazolam and fentanyl for angioplasty of dysfunctional arteriovenous access: A retrospective single-center analysis.
Topics: Aged; Angioplasty; Angioplasty, Balloon; Arteriovenous Shunt, Surgical; Fentanyl; Graft Occlusion, V | 2023 |
Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Routes; Emergencies; Female; Fentanyl; Huma | 2021 |
Analgesia for retinopathy of prematurity screening: A systematic review.
Topics: Acetaminophen; Analgesia; Fentanyl; Humans; Infant, Newborn; Nitrous Oxide; Pain; Pain Measurement; | 2022 |
Patterns of Palliation: A Review of Casualties That Received Pain Management Before Reaching Role 2 in Afghanistan.
Topics: Adult; Afghan Campaign 2001-; Afghanistan; Emergency Medical Services; Fentanyl; Humans; Ketamine; M | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
Comparison of different delivery modalities of epidural analgesia and intravenous analgesia in labour: a systematic review and network meta-analysis.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics; Analgesics, | 2023 |
Effect of Fentanyl for Preterm Infants on Mechanical Ventilation: A Systematic Review and Meta-Analysis.
Topics: Cerebral Hemorrhage; Child; Ductus Arteriosus, Patent; Fentanyl; Humans; Infant; Infant, Newborn; In | 2023 |
Non-opioid analgesics for procedural pain in neonates.
Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei | 2023 |
Opioids for procedural pain in neonates.
Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant; Infant, N | 2023 |
Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review.
Topics: Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Fentanyl; Humans; Hypnotics and | 2023 |
Opioids for procedural pain in neonates.
Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant, Newborn; | 2023 |
Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.
Topics: Analgesia; Child; Fentanyl; Humans; Ketamine; Ketorolac; Pain | 2023 |
Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
Topics: Analgesics; Anesthetics, Local; Apnea; Bradycardia; Fentanyl; Humans; Hypnotics and Sedatives; Infan | 2023 |
Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence.
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Drug Overdose; Female; Fentanyl; Germany; Humans | 2019 |
Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; C | 2019 |
The influence of pain, agitation, and their management on the immature brain.
Topics: Algorithms; Analgesics, Opioid; Brain; Chronic Pain; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2020 |
The influence of pain, agitation, and their management on the immature brain.
Topics: Algorithms; Analgesics, Opioid; Brain; Chronic Pain; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2020 |
The influence of pain, agitation, and their management on the immature brain.
Topics: Algorithms; Analgesics, Opioid; Brain; Chronic Pain; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2020 |
The influence of pain, agitation, and their management on the immature brain.
Topics: Algorithms; Analgesics, Opioid; Brain; Chronic Pain; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2020 |
Sufentanil versus fentanyl for pain relief in labor involving combined spinal-epidural analgesia: a systematic review and meta-analysis of randomized controlled trials.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Apgar Score; Female; Fentanyl; Huma | 2020 |
Reasons to avoid fentanyl.
Topics: Analgesics, Opioid; Fentanyl; Humans; Narcotics; Opioid-Related Disorders; Pain; Public Health; Unit | 2020 |
Opioid rotation from transdermal fentanyl to continuous subcutaneous hydromorphone in a cachectic patient: A case report and review of the literature.
Topics: Administration, Cutaneous; Analgesics, Opioid; Cachexia; Canada; Female; Fentanyl; Humans; Hydromorp | 2021 |
Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis.
Topics: Alfentanil; Analgesics, Opioid; Fentanyl; Humans; Laparoscopy; Morphine; Oxycodone; Pain; Pain Manag | 2021 |
Challenges of post-authorization safety studies: Lessons learned and results of a French study of fentanyl buccal tablet.
Topics: Administration, Buccal; Analgesics, Opioid; Diaries as Topic; Fentanyl; France; Humans; Intersectora | 2018 |
Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Mucosal; Administration, Oral | 2018 |
What Parenteral Opioids to Use in Face of Shortages of Morphine, Hydromorphone, and Fentanyl.
Topics: Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Hydromorphone; Morphine; Nalbuphine; Pain | 2018 |
DARK Classics in Chemical Neuroscience: Fentanyl.
Topics: Analgesics, Opioid; Anesthesia, General; Drug Industry; Drug Overdose; Epidemics; Fentanyl; Humans; | 2018 |
The transdermal delivery of fentanyl.
Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; | 2013 |
Transdermal fentanyl for cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pai | 2013 |
Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain.
Topics: Analgesics, Opioid; Appetite; Codeine; Consciousness; Fentanyl; Humans; Middle Aged; Morphine; Neopl | 2014 |
[A case of Guillain-Barré syndrome with severe pain successfully controlled with acetaminophen, gabapentin, and parenterally infused fentanyl].
Topics: Acetaminophen; Amines; Child; Cyclohexanecarboxylic Acids; Drug Combinations; Fentanyl; Gabapentin; | 2014 |
[New option in the management of cancer pain in Hungary: short acting oral opioid therapy].
Topics: Administration, Oral; Analgesics, Opioid; Analgesics, Short-Acting; Drug Administration Schedule; Dr | 2015 |
Opioid Pharmacokinetics-Pharmacodynamics: Clinical Implications in Acute Pain Management in Trauma.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Morphine; Pain; Pain Management; Pain Measureme | 2016 |
Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Androstanols; Anesthetics, Local; Child; Fentanyl; Humans; | 2016 |
[Analysis of the accessibility of short acting oral opioids in Hungary].
Topics: Administration, Oral; Analgesics, Opioid; Analgesics, Short-Acting; Drug Industry; Education, Medica | 2016 |
The use of opioids in cancer patients with renal impairment-a systematic review.
Topics: Analgesics, Opioid; Drug-Related Side Effects and Adverse Reactions; Fentanyl; Humans; Neoplasms; Pa | 2017 |
Analgesia in the surgical intensive care unit.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; C | 2017 |
[Driving ability under opioids: current assessment of published studies].
Topics: Accidents, Traffic; Administration, Cutaneous; Analgesics, Opioid; Automobile Driving; Buprenorphine | 2008 |
Pharmacotherapeutic management of breakthrough pain in patients with chronic persistent pain.
Topics: Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Pain | 2008 |
[Generics in pain therapy].
Topics: Administration, Cutaneous; Administration, Oral; Aged; Analgesics, Opioid; Chronic Disease; Drugs, G | 2008 |
[Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Chronic Disease; Disease Models, Animal; Drug Tolerance | 2008 |
Pediatric palliative care: use of opioids for the management of pain.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Child; Delayed-A | 2009 |
Treatment strategies for cancer patients with breakthrough pain.
Topics: Analgesics, Opioid; Animals; Fentanyl; Humans; Neoplasms; Pain; Pain Measurement; Treatment Outcome | 2009 |
Opioids in people with cancer-related pain.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Codeine; Fentanyl; Humans; Methadone; Neoplasm | 2008 |
The role of transdermal fentanyl patches in the effective management of cancer pain.
Topics: Acute Disease; Administration, Cutaneous; Analgesics, Opioid; Chemistry, Pharmaceutical; Chronic Dis | 2009 |
The role of fentanyl in cancer-related pain.
Topics: Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Palliative Care; United States | 2009 |
Transdermal fentanyl as a front-line approach to moderate-severe pain: a meta-analysis of randomized clinical trials.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain; Randomized Controlled Trials | 2009 |
Transdermal fentanyl: pharmacology and toxicology.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Drug Carriers; Drug Overdose; Fentan | 2009 |
Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer.
Topics: Administration, Intranasal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Placebos | 2010 |
[Fetal pain and intrauterine analgesia/anesthesia: neuroanatomy, ontogenesis and physiology of pain perception].
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Brain; Cardiovascular System; Electroencephalography; | 2010 |
Pharmacogenetics in obstetric anesthesia.
Topics: Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Codeine; Female; | 2010 |
Fentanyl patches: preventable overdose.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Drug Overdose; Fentanyl; Humans; Pai | 2010 |
Breakthrough pain: progress in management.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; P | 2010 |
Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis.
Topics: Administration, Oral; Analgesics, Opioid; Cohort Studies; Fentanyl; Humans; Morphine; Neoplasms; Pai | 2010 |
Treatment of breakthrough pain with fentanyl buccal tablet in opioid-tolerant patients with chronic pain: appropriate patient selection and management.
Topics: Administration, Buccal; Algorithms; Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; D | 2010 |
Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Adult; Aged; Biological | 2010 |
Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Adult; Aged; Biological | 2010 |
Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Adult; Aged; Biological | 2010 |
Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Adult; Aged; Biological | 2010 |
[The licit opioid consumption in Denmark].
Topics: Analgesics, Opioid; Buprenorphine; Databases, Factual; Denmark; Drug Costs; Drug Utilization; Fentan | 2010 |
[Solutions for the clinical problems of analgesics for cancer pain treatment in Japan].
Topics: Acetaminophen; Analgesics; Drug Administration Routes; Fentanyl; Humans; Japan; Neoplasms; Oxycodone | 2011 |
Long-term dosing, safety, and tolerability of fentanyl buccal tablet in the management of noncancer-related breakthrough pain in opioid-tolerant patients.
Topics: Administration, Buccal; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Controlled C | 2011 |
Integrated strategies for the successful management of breakthrough cancer pain.
Topics: Adult; Aged; Analgesics, Opioid; Breast Neoplasms; Drug Therapy, Combination; Female; Fentanyl; Huma | 2011 |
Transdermal opioids for cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine; Evidence-Based Medicine; Fentanyl; Hum | 2011 |
Fentanyl nasal spray for the treatment of cancer pain.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Drug Delivery Systems; Fentany | 2011 |
Fentanyl pectin nasal spray: in breakthrough pain in opioid-tolerant adults with cancer.
Topics: Analgesics, Opioid; Drug Tolerance; Fentanyl; Humans; Nasal Sprays; Neoplasms; Pain; Pectins | 2011 |
[Breakthrough pain--what to consider when treating with rapid onset opioids].
Topics: Administration, Intranasal; Administration, Oral; Administration, Sublingual; Algorithms; Chronic Di | 2011 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 4: is intranasal fentanyl better than parenteral morphine for managing acute severe pain in children?
Topics: Acute Disease; Administration, Intranasal; Analgesics, Opioid; Child; Child, Preschool; Evidence-Bas | 2011 |
Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain.
Topics: Administration, Oral; Analgesics, Opioid; Buprenorphine; Chronic Pain; Constipation; Fentanyl; Human | 2012 |
The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs.
Topics: Analgesics, Opioid; Animals; Delayed-Action Preparations; Dog Diseases; Dogs; Fentanyl; Pain | 2012 |
A review of the pharmacokinetic profile of transmucosal fentanyl formulations.
Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Mouth Mucosa; Pain | 2012 |
Limited evidence for intranasal fentanyl in the emergency department and the prehospital setting--a systematic review.
Topics: Administration, Intranasal; Analgesics, Opioid; Emergency Medical Services; Emergency Service, Hospi | 2013 |
The role of oral transmucosal fetanyl citrate in the management of breakthrough cancer pain.
Topics: Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Patient Selection | 2002 |
Partial versus full agonists for opioid-mediated analgesia--focus on fentanyl and buprenorphine.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Drug Delivery Systems; Drug Tolerance; Fentanyl; Humans; | 2002 |
The immune-suppressive effects of pain.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Cyclooxygenase Inhibitors; Fentanyl; Humans; Immune Tolera | 2003 |
[Palliative care for colon cancer patients as total pain management].
Topics: Analgesia, Epidural; Anticonvulsants; Antidepressive Agents; Colonic Neoplasms; Drug Therapy, Combin | 2003 |
Benefit-risk assessment of transdermal fentanyl for the treatment of chronic pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Body Weight; Chronic Disease; Female; Fentanyl; Human | 2003 |
Morphine is not the only analgesic in palliative care: literature review.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pa | 2004 |
Clinical experience with transdermal fentanyl for the treatment of cancer pain in Germany.
Topics: Administration, Cutaneous; Clinical Trials as Topic; Constipation; Fentanyl; Germany; Humans; Narcot | 2004 |
Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2004 |
Managing breakthrough pain: a clinical review with three case studies using oral transmucosal fentanyl citrate.
Topics: Administration, Buccal; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Administration Sche | 2004 |
Cancer pain management in children.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Child; Chronic Disease; Fentanyl; Humans; Injections, Sp | 2004 |
What to learn from in vivo opioidergic brain imaging?
Topics: Analgesics, Opioid; Brain; Diprenorphine; Fentanyl; Humans; Ligands; Narcotic Antagonists; Pain; Pos | 2005 |
Fentanyl for acute pain management.
Topics: Administration, Cutaneous; Adult; Age Factors; Analgesia, Epidural; Analgesia, Patient-Controlled; A | 2005 |
Patching together transdermal pain control options.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain | 2005 |
[Basic studies on cancer pain control].
Topics: Analgesics, Opioid; Animals; Constipation; Dose-Response Relationship, Drug; Fentanyl; Humans; Morph | 2005 |
Opioids for the management of breakthrough (episodic) pain in cancer patients.
Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Morphine; Neoplasms; Pain; Pain Measurem | 2006 |
Transdermal buprenorphine in cancer pain and palliative care.
Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine; Drug Interactions; Fentanyl; Humans; N | 2006 |
Cancer-related breakthrough pain.
Topics: Administration, Buccal; Administration, Oral; Analgesics, Opioid; Dose-Response Relationship, Drug; | 2006 |
Opioids for management of breakthrough pain in cancer patients.
Topics: Administration, Oral; Analgesics, Opioid; Evidence-Based Medicine; Fentanyl; Humans; Neoplasms; Pain | 2006 |
Fentanyl buccal tablet: in breakthrough pain in opioid-tolerant patients with cancer.
Topics: Administration, Buccal; Analgesics, Opioid; Animals; Drug Tolerance; Fentanyl; Humans; Mouth Mucosa; | 2006 |
A titration strategy is needed to manage breakthrough cancer pain effectively: observations from data pooled from three clinical trials.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Humans; | 2007 |
[Intranasal opioids for acute pain].
Topics: Absorption; Acute Disease; Administration, Intranasal; Adult; Analgesia, Patient-Controlled; Analges | 2006 |
Transdermal fentanyl in childhood and adolescence: a comprehensive literature review.
Topics: Administration, Cutaneous; Adolescent; Child; Drug Delivery Systems; Fentanyl; Humans; Narcotics; Pa | 2007 |
Fentanyl buccal tablet: faster rescue analgesia for breakthrough pain?
Topics: Administration, Buccal; Analgesia; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Randomized | 2007 |
Oral transmucosal fentanyl citrate in cancer pain management: a practical application of nanotechnology.
Topics: Administration, Oral; Analgesics, Opioid; Clinical Trials as Topic; Drug Carriers; Fentanyl; Humans; | 2007 |
The use of oral transmucosal fentanyl citrate during high-dose-rate gynecologic brachytherapy.
Topics: Administration, Oral; Ambulatory Care; Analgesia; Analgesics, Opioid; Brachytherapy; Clinical Trials | 2007 |
Actiq: an effective oral treatment for cancer-related breakthrough pain.
Topics: Administration, Buccal; Analgesics, Opioid; Chemistry, Pharmaceutical; Community Health Nursing; Dru | 2007 |
The management of pain in children with life-limiting illnesses.
Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth | 2007 |
Fentanyl buccal tablet: rapid relief from breakthrough pain.
Topics: Administration, Buccal; Analgesics, Opioid; Animals; Fentanyl; Humans; Pain; Pain Measurement; Patie | 2007 |
Fentanyl buccal tablet.
Topics: Administration, Buccal; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Neoplasms; Pain; Pain | 2008 |
Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Delayed-Action P | 2008 |
Management of pain in the older person with cancer. Part 2: treatment options.
Topics: Age Factors; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Buprenorphine; Female; Fentany | 2008 |
Effectiveness of opioids in the treatment of chronic non-cancer pain.
Topics: Analgesics, Opioid; Drug Administration Schedule; Fentanyl; Humans; Methadone; Morphine; Oxycodone; | 2008 |
The role of the endogenous opioid system in the human stress response.
Topics: Endorphins; Fentanyl; Humans; Hydrocortisone; Intraoperative Period; Morphine; Naloxone; Pain; Pain, | 1983 |
Systemic analgesia during labor.
Topics: Acid-Base Equilibrium; Analgesics; Animals; Child Behavior; Diazepam; Female; Fentanyl; Fetal Heart; | 1982 |
Recent advances in acute pain management.
Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; | 1995 |
Transdermal fentanyl therapy: system design, pharmacokinetics and efficacy.
Topics: Administration, Cutaneous; Drug Evaluation; Fentanyl; Humans; Neoplasms; Pain | 1995 |
Oral transmucosal fentanyl. Help or hindrance?
Topics: Absorption; Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Child; Child, Preschool; C | 1994 |
Comment: transdermal fentanyl.
Topics: Administration, Cutaneous; Adult; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Neopl | 1993 |
Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control.
Topics: Analgesics, Opioid; Fentanyl; Humans; Pain | 1997 |
[Transdermal opioid administration: the pain plaster].
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Morphine; Pain; Pain, Intractable | 1997 |
[Treatment of pain in oncology].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl; | 1997 |
Current strategies for pain control.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Bone Neoplasms; Fentanyl; Humans; Neoplasms; Pain; Pai | 1997 |
Pharmacokinetic and pharmacodynamic issues in the treatment of breakthrough pain.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Administration, Subling | 1997 |
Fentanyl in the treatment of cancer pain.
Topics: Administration, Cutaneous; Administration, Oral; Biological Availability; Chronic Disease; Fentanyl; | 1997 |
Caring for adults with chronic cancer pain.
Topics: Adult; Analgesics; Analgesics, Opioid; Chronic Disease; Female; Fentanyl; Humans; Neoplasms; Oncolog | 1998 |
[Pharma clinics. How I treat...or preventing pain with "patches"].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Local; Fentanyl; Lidocaine; Lidocaine, P | 1998 |
A review of the use of fentanyl analgesia in the management of acute pain in adults.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Fentanyl; Humans; Middle Aged; Pain | 1999 |
Practice guidelines for cancer pain therapy. Issues pertinent to the revision of national guidelines.
Topics: Analgesics; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Morphine; Neoplasms; Pain; Pain Mana | 1998 |
Alternatives to oral opioids for cancer pain.
Topics: Administration, Oral; Administration, Topical; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; | 1999 |
Analgesics in the management of chronic pain. Part five: Step 3 parenteral analgesic drug therapy.
Topics: Administration, Cutaneous; Analgesics; Chronic Disease; Fentanyl; Heroin; Humans; Infusions, Parente | 1999 |
Opioid rotation for cancer pain: rationale and clinical aspects.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Narcotics; Neoplasms; Pain | 1999 |
Managing breakthrough cancer pain: a new approach.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle Aged; Neopla | 1999 |
Clinical pharmacokinetics of transdermal opioids: focus on transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Fentanyl; Humans; Pain | 2000 |
An alternative algorithm for dosing transdermal fentanyl for cancer-related pain.
Topics: Administration, Cutaneous; Algorithms; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain | 2000 |
Results of the clinical trial of transdermal therapeutic system-fentanyl in strong opioid pre-treated adult patients with cancer-related pain.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration | 2000 |
New developments in cancer pain therapy.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Analgesics, Opioid; Cell Transplantation; Cyclooxygenase | 2000 |
Strong opioids for cancer pain.
Topics: Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Morphine; Neoplasms; Neurotoxicity Syndromes; | 2001 |
Contemporary drug therapy in palliative care: new directions.
Topics: Adrenal Cortex Hormones; Analgesics; Anorexia; Antiemetics; Antitussive Agents; Cachexia; Cough; Dru | 2001 |
[Issues in cancer pain management].
Topics: Analgesics, Opioid; Chronic Disease; Clinical Protocols; Fentanyl; Home Care Services; Humans; Morph | 2001 |
Pain management in the critically ill child.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Child, Preschool; Critical Illness; Fentan | 2001 |
Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control.
Topics: Absorption; Administration, Cutaneous; Analgesia; Analgesics, Opioid; Digestive System; Drug Interac | 2001 |
Treatment of cancer pain with transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Pharmaceutical Pre | 2001 |
[Pain relief during labor].
Topics: Analgesia, Epidural; Anesthetics; Bupivacaine; Female; Fentanyl; Humans; Labor, Obstetric; Nerve Blo | 1999 |
[New opioid preparations in the treatment of pain].
Topics: Administration, Cutaneous; Analgesics, Opioid; Clinical Competence; Fentanyl; Humans; Hydromorphone; | 1999 |
E-TRANS fentanyl. ALZA.
Topics: Analgesics, Opioid; Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; | 2002 |
[Cardiogenic shock: clinical manifestations and treatment].
Topics: Blood Gas Analysis; Dextrans; Dopamine; Droperidol; Fentanyl; Hemodynamics; Humans; Isoproterenol; P | 1975 |
[Pain control during the expulsion period in labor using bupivacaine and fentanyl].
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Drug Evaluation; Drug Therapy, Combinati | 1992 |
Transdermal fentanyl.
Topics: Administration, Cutaneous; Aged; Chemistry, Pharmaceutical; Chronic Disease; Clinical Trials as Topi | 1992 |
Transdermal fentanyl: long-term analgesic studies.
Topics: Administration, Cutaneous; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Neoplasms; P | 1992 |
Transdermal fentanyl in cancer pain.
Topics: Administration, Cutaneous; Fentanyl; Humans; Neoplasms; Pain | 1992 |
Management of pain in the newborn infant.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant | 1991 |
Transdermally administered fentanyl for pain management.
Topics: Administration, Cutaneous; Animals; Chronic Disease; Contraindications; Fentanyl; Humans; Neoplasms; | 1992 |
[Use of epidural and intrathecal opiates in obstetrics].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthe | 1989 |
The pharmacologic management of pain in children.
Topics: Analgesia, Epidural; Analgesics; Child; Child, Preschool; Codeine; Fentanyl; Humans; Infant; Meperid | 1989 |
Management of pediatric pain with opioid analgesics.
Topics: Analgesics, Opioid; Child; Codeine; Fentanyl; Humans; Infant; Meperidine; Morphine; Narcotic Antagon | 1988 |
Alfentanil in anesthesia and analgesia.
Topics: Alfentanil; Analgesia; Anesthesia; Blood Proteins; Drug Compounding; Drug Interactions; Fentanyl; Fo | 1986 |
Evoked potentials as correlates of pain and pain relief in man.
Topics: Acupuncture Therapy; Analgesics; Brain; Dental Pulp; Evoked Potentials; Fentanyl; Humans; Naloxone; | 1986 |
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me | 1972 |
[Management of cardiogenic shock].
Topics: Bradycardia; Dextrans; Digitalis Glycosides; Droperidol; Electric Countershock; Electroconvulsive Th | 1973 |
Trials
366 trials available for fentanyl and Pain
| Article | Year |
|---|---|
'NOPAIN-ROP' trial: Intravenous fentanyl and intravenous ketamine for pain relief during laser photocoagulation for retinopathy of prematurity (ROP) in preterm infants: A randomised trial.
Topics: Fentanyl; Humans; Infant; Infant, Newborn; Infant, Premature; Ketamine; Lasers; Light Coagulation; P | 2021 |
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives; | 2022 |
Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery.
Topics: Analgesics, Opioid; Cataract; Double-Blind Method; Epinephrine; Fentanyl; Humans; Ketorolac; Pain; P | 2022 |
Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT).
Topics: Analgesics, Opioid; Conscious Sedation; Cough; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Seda | 2022 |
A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess.
Topics: Abscess; Administration, Intranasal; Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Dra | 2022 |
Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anxiety; Dexmedetomidine; Female; Fentanyl; Genotype; Human | 2022 |
Intranasal Fentanyl to Reduce Pain and Improve Oral Intake in the Management of Children With Painful Infectious Mouth Lesions.
Topics: Acetaminophen; Administration, Intranasal; Analgesics, Opioid; Child; Child, Preschool; Communicable | 2022 |
Ketamine Compared With Fentanyl for Surgical Abortion: A Randomized Controlled Trial.
Topics: Double-Blind Method; Female; Fentanyl; Humans; Ketamine; Midazolam; Pain; Pregnancy | 2022 |
Comparison of Propofol-Fentanyl with Midazolam-Ketamine Combination in Pediatric Patients Undergoing Kidney Biopsy.
Topics: Analgesics; Biopsy; Child; Fentanyl; Humans; Ketamine; Kidney; Midazolam; Pain; Propofol | 2022 |
Transdermal fentanyl patch versus standard analgesia in postoperative oral submucous fibrosis patients: a triple blinded, randomised control trial.
Topics: Analgesia; Analgesics, Opioid; Fentanyl; Humans; Oral Submucous Fibrosis; Pain; Transdermal Patch | 2022 |
The Effects of Listening to the Qur'an in the Postoperative Management of the Patients Undergoing Laparoscopic Cholecystectomy in the Day Surgery Unit.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Cholecystectomy, Laparoscopic; Fentanyl; | 2023 |
A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia; Cross-Sectional Studies; Cytokines; Female; Fentanyl; Gastric | 2022 |
Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL).
Topics: Analgesics; Fentanyl; Humans; Ketoprofen; Lithiasis; Lithotripsy; Midazolam; Music; Nitrous Oxide; P | 2022 |
The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial.
Topics: Child; Cross-Over Studies; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Neoplasms | 2022 |
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
Efficacy of type-I and type-II pectoral nerve blocks (PECS I and II) in patients undergoing mastectomy: a prospective randomised clinical trial.
Topics: Anesthetics, Local; Breast Neoplasms; Female; Fentanyl; Humans; Mastectomy; Middle Aged; Pain; Prosp | 2022 |
Efficacy of type-I and type-II pectoral nerve blocks (PECS I and II) in patients undergoing mastectomy: a prospective randomised clinical trial.
Topics: Anesthetics, Local; Breast Neoplasms; Female; Fentanyl; Humans; Mastectomy; Middle Aged; Pain; Prosp | 2022 |
Efficacy of type-I and type-II pectoral nerve blocks (PECS I and II) in patients undergoing mastectomy: a prospective randomised clinical trial.
Topics: Anesthetics, Local; Breast Neoplasms; Female; Fentanyl; Humans; Mastectomy; Middle Aged; Pain; Prosp | 2022 |
Efficacy of type-I and type-II pectoral nerve blocks (PECS I and II) in patients undergoing mastectomy: a prospective randomised clinical trial.
Topics: Anesthetics, Local; Breast Neoplasms; Female; Fentanyl; Humans; Mastectomy; Middle Aged; Pain; Prosp | 2022 |
Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial.
Topics: Analgesia, Patient-Controlled; Analgesics; Electroacupuncture; Female; Fentanyl; Humans; Pain; Pregn | 2023 |
Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial.
Topics: Analgesia, Patient-Controlled; Analgesics; Electroacupuncture; Female; Fentanyl; Humans; Pain; Pregn | 2023 |
Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial.
Topics: Analgesia, Patient-Controlled; Analgesics; Electroacupuncture; Female; Fentanyl; Humans; Pain; Pregn | 2023 |
Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial.
Topics: Analgesia, Patient-Controlled; Analgesics; Electroacupuncture; Female; Fentanyl; Humans; Pain; Pregn | 2023 |
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Lidocaine; Pain; Prospective Studies | 2023 |
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Lidocaine; Pain; Prospective Studies | 2023 |
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Lidocaine; Pain; Prospective Studies | 2023 |
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Lidocaine; Pain; Prospective Studies | 2023 |
Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Cross-Over Studies; Emergency Medical Services; Fe | 2023 |
Re: Re: Transdermal fentanyl patch versus standard analgesia in postoperative oral submucous fibrosis patients: A triple blinded, randomised control trial.
Topics: Analgesia; Analgesics, Opioid; Fentanyl; Humans; Oral Submucous Fibrosis; Pain; Pain Management; Pai | 2023 |
Intravenous paracetamol for persistent pain after endoscopic mucosal resection discriminates patients at risk of adverse events and those who can be safely discharged.
Topics: Acetaminophen; Colonoscopy; Endoscopic Mucosal Resection; Female; Fentanyl; Humans; Pain; Patient Di | 2023 |
Analgesic effect of erector spinae plane block after cesarean section: A randomized controlled trial.
Topics: Anesthesia, Spinal; Bupivacaine; Cesarean Section; Female; Fentanyl; Humans; Nerve Block; Pain; Preg | 2023 |
Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial.
Topics: Fentanyl; Humans; Infant; Infant, Newborn; Oxygen; Pain; Pain Measurement; Retinopathy of Prematurit | 2023 |
Comparison of the Analgesic Efficacy of Lidocaine Spray versus Tramadol and Fentanyl for Pain Control in Rib Fractures.
Topics: Adult; Analgesics; Analgesics, Opioid; Anesthetics, Local; Fentanyl; Humans; Lidocaine; Middle Aged; | 2023 |
Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial.
Topics: Adolescent; Analgesics, Opioid; Child; Double-Blind Method; Fentanyl; Headache; Humans; Ibuprofen; P | 2023 |
The efficacy of intradermal sterile water application in severe renal colic: a randomised clinical trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Fentanyl; Humans; Injectio | 2023 |
The Impact of Head Elevation on Prevalence and Severity of Emergence Cough in Male Patients during Endotracheal Extubation.
Topics: Airway Extubation; Cough; Fentanyl; Humans; Intubation, Intratracheal; Male; Pain; Prevalence | 2023 |
Pre-emptive analgesia with continuous fascia iliaca compartment block reduces postoperative delirium in elderly patients with hip fracture. A randomized controlled trial.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Delirium; Double-Blind Method; Fe | 2019 |
Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Female; Fentanyl; Health Education; Humans; Male; Middle Ag | 2020 |
Use of acupuncture as adjuvant analgesic technique in dogs undergoing thoracolumbar hemilaminectomy.
Topics: Acupuncture Therapy; Analgesia; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Fentanyl; Intervert | 2020 |
Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study.
Topics: Administration, Inhalation; Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Inh | 2021 |
Midazolam as an active placebo in 3 fentanyl-validated nociceptive pain models.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Fentanyl; Healthy Volunteers; Hu | 2017 |
Evaluation of Paracervical Block and IV Sedation for Pain Management during Hysteroscopic Polypectomy: A Randomized Clinical Trial.
Topics: Adult; Anesthesia, Obstetrical; Female; Fentanyl; Humans; Hysteroscopy; Iran; Lidocaine; Middle Aged | 2017 |
Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Antitussive Agents; Bridged Bicyclo Compounds, Heterocy | 2017 |
Intravenous dexamethasone as an adjunct to improve labor analgesia: A randomized, double-blinded, placebo controlled clinical trial.
Topics: Adjuvants, Anesthesia; Administration, Intravenous; Adult; Analgesia, Epidural; Analgesia, Obstetric | 2017 |
Effects of epidural anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Antiemetics; Female; Fentanyl; | 2018 |
Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study.
Topics: Administration, Intranasal; Adolescent; Analgesics; Child; Child, Preschool; Double-Blind Method; Fe | 2021 |
Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial.
Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, | 2018 |
[Comparison between Dexmedetomidine and Fentanyl Infusion during Fetoscopic Laser Photocoagulation for Twin to Twin Transfusion Syndrome].
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Dexmedetomidine; Female; Fentanyl; Fetofetal T | 2017 |
Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial.
Topics: Administration, Intranasal; Adolescent; Analgesics; Analgesics, Opioid; Child; Double-Blind Method; | 2019 |
Prehospital intravenous fentanyl administered by ambulance personnel: a cluster-randomised comparison of two treatment protocols.
Topics: Allied Health Personnel; Analgesics, Opioid; Denmark; Dose-Response Relationship, Drug; Emergency Me | 2019 |
Evaluation of Analgesic Patches in Cynomolgus Macaques (
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Area Under Curve; Buprenorphine; Cross-Over | 2019 |
Analgesia-first sedation in critically ill adults: A U.S. pilot, randomized controlled trial.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesia; California; Clinical Protocols; Critical Illness; D | 2019 |
Discovering Pain in Newborn Infants.
Topics: Anesthetics, Intravenous; Ductus Arteriosus, Patent; Fentanyl; Humans; Infant, Newborn; Pain; Postop | 2019 |
Pre-medication with sublingual fentanyl did not relieve pain associated with bone marrow aspiration and biopsy: a randomized feasibility trial.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Biopsy, Needle; Bone | 2013 |
Moderate procedural sedation and opioid analgesia during transradial coronary interventions to prevent spasm: a prospective randomized study.
Topics: Aged; Analgesics, Opioid; Arterial Occlusive Diseases; Chi-Square Distribution; Conscious Sedation; | 2013 |
A novel approach to pharmaco-EEG for investigating analgesics: assessment of spectral indices in single-sweep evoked brain potentials.
Topics: Adult; Analgesics, Opioid; Brain; Buprenorphine; Cross-Over Studies; Data Interpretation, Statistica | 2013 |
Efficacy and safety of continuous infusion of fentanyl for pain control in preterm newborns on mechanical ventilation.
Topics: Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Follow-Up Studies; Humans; Infant, Newbor | 2013 |
Comparison of the efficacy of dexmedetomidine plus fentanyl patient-controlled analgesia with fentanyl patient-controlled analgesia for pain control in uterine artery embolization for symptomatic fibroid tumors or adenomyosis: a prospective, randomized st
Topics: Adenomyosis; Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Chemoembolization, Therapeutic; Dexmed | 2013 |
Comparison of three methods of preventing rocuronium induced pain on injection using venous occlusion technique: a randomized prospective double blind controlled study.
Topics: Adult; Aged; Androstanols; Double-Blind Method; Female; Fentanyl; Humans; Injections, Intravenous; L | 2013 |
A randomized crossover clinical trial to evaluate the efficacy of oral transmucosal fentanyl citrate in the treatment of dyspnea on exertion in patients with advanced cancer.
Topics: Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Female; Fe | 2015 |
Efficacy and safety of a six-hour continuous overlap method for converting intravenous to transdermal fentanyl in cancer pain.
Topics: Administration, Cutaneous; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, | 2014 |
Comparison of anaesthetic and analgesic effects of emulsified isoflurane used alone or combined with lidocaine and fentanyl in dogs.
Topics: Analgesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Animals; Dogs; Dru | 2014 |
Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).
Topics: Analgesics, Opioid; Cohort Studies; Europe; Female; Fentanyl; Genetic Association Studies; Genetic V | 2012 |
[Breakthrough pain treatment with sublingual fentanyl in patients with chronic cutaneous ulcers].
Topics: Administration, Sublingual; Aged; Chronic Disease; Constipation; Female; Fentanyl; Humans; Male; Mid | 2014 |
Pretreatment with remifentanil, fentanyl, or lidocaine to prevent withdrawal after rocuronium using venous occlusion technique in children and adolescents: a prospective randomized placebo-controlled double-blind study.
Topics: Adolescent; Androstanols; Anesthesia, General; Child; Child, Preschool; Double-Blind Method; Female; | 2014 |
Progressive change in joint degeneration in patients with knee or hip osteoarthritis treated with fentanyl in a randomized trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Disease Progression; Female; Fentanyl; Humans; Male; Mi | 2014 |
[Opioid induction using rapid release drugs and the shift to fentanyl patches].
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Humans; Ma | 2014 |
Dynamic interactions between plasma IL-1 family cytokines and central endogenous opioid neurotransmitter function in humans.
Topics: Amygdala; Anxiety Disorders; Carbon Radioisotopes; Female; Fentanyl; Functional Neuroimaging; Humans | 2015 |
A randomized controlled trial of fentanyl in the pre-emptive treatment of pain associated with turning in patients under mechanical ventilation: research protocol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Critical Care; Double-Blind Method; | 2015 |
Efficacy and safety of transdermal fentanyl for the treatment of oral mucositis pain caused by chemoradiotherapy in patients with esophageal squamous cell carcinoma.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Carcinoma, Squamous Cell; Chemoradiother | 2015 |
Comparison of intrathecal bupivacaine, levobupivacaine for cesarean section.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Method; F | 2014 |
Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy.
Topics: Adult; Aged; Analgesics, Opioid; Drug Combinations; Endoscopy, Gastrointestinal; Female; Fentanyl; H | 2014 |
Text messaging reduces analgesic requirements during surgery.
Topics: Adult; Female; Fentanyl; Humans; Male; Narcotics; Pain; Pain Management; Text Messaging | 2015 |
[Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl].
Topics: Acupuncture Points; Adolescent; Adult; Aged; Burns; Female; Fentanyl; Humans; Male; Middle Aged; Pai | 2014 |
Sedation and analgesia with fentanyl and etomidate for intrathecal injection in childhood leukemia patients.
Topics: Anesthetics, Intravenous; Child; Etomidate; Female; Fentanyl; Humans; Injections, Spinal; Leukemia; | 2015 |
[Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation].
Topics: Aged; Analgesics; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Ca | 2014 |
Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Androstanols; Antieme | 2015 |
The clinical effect of fentanyl in comparison with ketamine in analgesic effect for oncology procedures in children: a randomized, double-blinded, crossover trial.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Child, Preschool; Cross-Over Studies; Double-Blin | 2015 |
Improving the Management of Vaso-Occlusive Episodes in the Pediatric Emergency Department.
Topics: Administration, Intranasal; Adolescent; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Child; | 2015 |
Fentanyl as pre-emptive treatment of pain associated with turning mechanically ventilated patients: a randomized controlled feasibility study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Critical Care; Double-Blind Method; Feasibility | 2016 |
Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP.
Topics: Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dose- | 2015 |
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D | 2016 |
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D | 2016 |
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D | 2016 |
Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; D | 2016 |
[Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit].
Topics: Analgesics; Circadian Rhythm; Critical Care; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics | 2016 |
The median effective concentration (EC50) of propofol with different doses of fentanyl during colonoscopy in elderly patients.
Topics: Aged; Aged, 80 and over; Anesthetics, Intravenous; Colonoscopy; Dose-Response Relationship, Drug; Do | 2016 |
[A study of using dexmedetomidine in ventilator bundle treatment in an ICU].
Topics: Arterial Pressure; Blood Pressure; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedati | 2015 |
Routine vs. on-demand analgesia in colonoscopy: a randomized clinical trial.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesia Recovery Period; Cecum; Colonoscopy; Female; Fentany | 2016 |
Study protocol of a randomised controlled trial of intranasal ketamine compared with intranasal fentanyl for analgesia in children with suspected, isolated extremity fractures in the paediatric emergency department.
Topics: Administration, Intranasal; Adolescent; Analgesia; Analgesics; Analgesics, Opioid; Child; Child, Pre | 2016 |
Entropy vs standard clinical monitoring using total intravenous anesthesia during transvaginal oocyte retrieval in patients for in vitro fertilization.
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Fentanyl; Fer | 2016 |
Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial.
Topics: Adult; Analgesics, Opioid; Biomarkers; Cross-Over Studies; Double-Blind Method; Fentanyl; Glycopepti | 2017 |
Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation.
Topics: Anesthetics, Intravenous; Child Behavior Disorders; Child, Preschool; Cognition Disorders; Developme | 2017 |
A randomized, open, parallel group, multicenter trial to investigate analgesic efficacy and safety of a new transdermal fentanyl patch compared to standard opioid treatment in cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Bandages; Delayed-Action Preparations; Europe; Female | 2008 |
Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.
Topics: Adult; Ambulatory Surgical Procedures; Female; Fentanyl; Humans; Male; Methyl Ethers; Nausea; Pain; | 2008 |
Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs.
Topics: Analgesics, Opioid; Animals; Dogs; Female; Fentanyl; Kidney; Kidney Function Tests; Male; Morphine; | 2008 |
Pediatric oncology sedation trial (POST): A double-blind randomized study.
Topics: Adolescent; Antiemetics; Antineoplastic Agents; Biopsy, Needle; Bone Marrow Examination; Child; Chil | 2008 |
Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery.
Topics: Administration, Intranasal; Analgesics, Opioid; Biological Availability; Cross-Over Studies; Dose-Re | 2008 |
Comparison of three doses of epidural fentanyl followed by bupivacaine and fentanyl for labor analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Dose-Response Relationship, Drug; F | 2008 |
Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Antineoplastic Combined Chem | 2008 |
[Comparison of TD-fentanyl with sustained-release morphine in the pain treatment of patients with lung cancer].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Female; | 2008 |
Comparison of intrathecal magnesium, fentanyl, or placebo combined with bupivacaine 0.5% for parturients undergoing elective cesarean delivery.
Topics: Adult; Bupivacaine; Cesarean Section; Drug Combinations; Female; Fentanyl; Humans; Injections, Spina | 2009 |
Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy.
Topics: Administration, Inhalation; Adult; Aged; Anesthetics, Combined; Attitude of Health Personnel; Colono | 2009 |
Fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic cancer pain: A long-term, open-label safety study.
Topics: Administration, Buccal; Analgesics, Opioid; Chronic Disease; Disease Progression; Drug Tolerance; Fe | 2009 |
Analgesia during abdominal aortic aneurysm endovascular repair: remifentanil vs. fentanyl-midazolam--a randomized controlled trial.
Topics: Aged; Analgesia; Analgesics, Opioid; Aortic Aneurysm, Abdominal; Area Under Curve; Blood Pressure; C | 2009 |
Opioids switching with transdermal systems in chronic cancer pain.
Topics: Adult; Aged; Analgesia; Analgesics, Opioid; Buprenorphine; Chronic Disease; Female; Fentanyl; Humans | 2009 |
Transdermal fentanyl in cachectic cancer patients.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Body Mass Index; Cachexia; C | 2009 |
Nebulized fentanyl versus intravenous morphine in children with suspected limb fractures in the emergency department: a randomized controlled trial.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Analgesics, Opioid; Analysis of Variance; Chi | 2009 |
Efficacy and tolerability of intranasal fentanyl spray 50 to 200 microg for breakthrough pain in patients with cancer: a phase III, multinational, randomized, double-blind, placebo-controlled, crossover trial with a 10-month, open-label extension treatmen
Topics: Administration, Intranasal; Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Disease Progression | 2009 |
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha | 2010 |
A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial.
Topics: Administration, Intranasal; Administration, Oral; Adult; Algorithms; Cross-Over Studies; Dose-Respon | 2009 |
A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial.
Topics: Administration, Intranasal; Administration, Oral; Adult; Algorithms; Cross-Over Studies; Dose-Respon | 2009 |
A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial.
Topics: Administration, Intranasal; Administration, Oral; Adult; Algorithms; Cross-Over Studies; Dose-Respon | 2009 |
A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial.
Topics: Administration, Intranasal; Administration, Oral; Adult; Algorithms; Cross-Over Studies; Dose-Respon | 2009 |
Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Drug Administr | 2008 |
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Double-B | 2009 |
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Double-B | 2009 |
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Double-B | 2009 |
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Double-B | 2009 |
Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia.
Topics: Administration, Intranasal; Analgesics, Opioid; Child, Preschool; Emergency Medical Services; Female | 2009 |
Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia.
Topics: Administration, Intranasal; Analgesics, Opioid; Child, Preschool; Emergency Medical Services; Female | 2009 |
Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia.
Topics: Administration, Intranasal; Analgesics, Opioid; Child, Preschool; Emergency Medical Services; Female | 2009 |
Intranasal fentanyl in 1-3-year-olds: a prospective study of the effectiveness of intranasal fentanyl as acute analgesia.
Topics: Administration, Intranasal; Analgesics, Opioid; Child, Preschool; Emergency Medical Services; Female | 2009 |
Hemispheric synchronized sounds and perioperative analgesic requirements.
Topics: Acoustic Stimulation; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesics; Analgesic | 2010 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Dosage Forms; Dose-Response Relationship, D | 2010 |
Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study.
Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Ov | 2010 |
In-office thermachoice III ablation: a comparison of two anesthetic techniques.
Topics: Administration, Cutaneous; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Local; Co | 2010 |
Transdermal fentanyl for pain caused by radiotherapy in head and neck cancer patients treated in an outpatient setting: a multicenter trial in Taiwan.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Head and Neck Neoplasm | 2010 |
[Effects of intravenous midazolam, fentanyl or ketamine on pain relief during performance of epidural anesthesia].
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia, Epidural; Female; Fentanyl; Humans; Hypnoti | 2009 |
Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography.
Topics: Administration, Intranasal; Analgesics, Opioid; Child; Child, Preschool; Double-Blind Method; Female | 2010 |
Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair.
Topics: Abdominal Pain; Adolescent; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Bupiva | 2010 |
A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensity.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cohort Studies; Cross-Over Studies; Double-Blind Meth | 2010 |
Single-dose pharmacokinetics of fentanyl buccal soluble film.
Topics: Administration, Buccal; Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Cross- | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmede | 2010 |
[A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Fentanyl; H | 2010 |
Six- versus 12-h conversion method from intravenous to transdermal fentanyl in chronic cancer pain: a randomized study.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Chronic Disease; Double-Blind Method; Female; F | 2011 |
Long-term safety and tolerability of fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic pain: an 18-month study.
Topics: Administration, Buccal; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Dise | 2010 |
Pharmacokinetics, analgesic effect, and tolerability of a single preprocedural dose of intranasal fentanyl in patients undergoing drain removal after breast reduction or augmentation surgery: A prospective, randomized, double-blind, placebo-controlled stu
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Device Removal; Double-Blind Meth | 2010 |
A multicenter, placebo-controlled, double-blind, multiple-crossover study of Fentanyl Pectin Nasal Spray (FPNS) in the treatment of breakthrough cancer pain.
Topics: Administration, Intranasal; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Female; Fen | 2010 |
A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain.
Topics: Administration, Buccal; Adult; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Double-Blind | 2010 |
[A phase II clinical study of once-a-day fentanyl citrate patch in patients with cancer pain--switching from once-every-three-days fentanyl patch to once-a-day fentanyl citrate patch].
Topics: Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain | 2010 |
The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study.
Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tole | 2011 |
Low doses of transdermal fentanyl in opioid-naive patients with cancer pain.
Topics: Aged; Analgesia; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Mal | 2010 |
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Capsaicin; Cold Temperature; Cross-Over Studies; Dose-Resp | 2011 |
A prospective, randomized, double-blind, multicenter study comparing remifentanil with fentanyl in mechanically ventilated patients.
Topics: Aged; Analgesics, Opioid; Consciousness; Critical Care; Double-Blind Method; Endpoint Determination; | 2011 |
Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentany | 2010 |
Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentany | 2010 |
Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentany | 2010 |
Use of intranasal fentanyl for the relief of pediatric orthopedic trauma pain.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentany | 2010 |
Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.
Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Capsaicin; Cross-Over Stud | 2011 |
Long-term effectiveness and tolerability of sublingual fentanyl orally disintegrating tablet for the treatment of breakthrough cancer pain.
Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analge | 2011 |
Efficacy of oxycodone/paracetamol for patients with bone-cancer pain: a multicenter, randomized, double-blinded, placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Bone Neopla | 2012 |
Efficacy of fentanyl and/or lidocaine on total antioxidants and total oxidants during craniotomy.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Antioxidants; Craniotomy; Double-Blind Method; | 2011 |
The efficacy and safety of fentanyl buccal tablet compared with immediate-release oxycodone for the management of breakthrough pain in opioid-tolerant patients with chronic pain.
Topics: Administration, Buccal; Adult; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Disease Mana | 2011 |
Consistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain.
Topics: Administration, Intranasal; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Over Studies; | 2011 |
Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized controlled trial.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Australia; Child; Child, | 2011 |
Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized controlled trial.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Australia; Child; Child, | 2011 |
Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized controlled trial.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Australia; Child; Child, | 2011 |
Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized controlled trial.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Australia; Child; Child, | 2011 |
Fentanyl pretreatment for alleviation of perineal symptoms following preoperative administration of intravenous dexamethasone sodium phosphate--a prospective, randomized, double blind, placebo controlled study.
Topics: Adult; Analgesics, Opioid; Dexamethasone; Double-Blind Method; Female; Fentanyl; Glucocorticoids; Hu | 2010 |
Sublingual fentanyl orally disintegrating tablet in daily practice: efficacy, safety and tolerability in patients with breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Algorithms; Analgesics, Opioid; Female; | 2011 |
The effectiveness and adverse events of morphine versus fentanyl on a physician-staffed helicopter.
Topics: Adult; Air Ambulances; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Humans; Male; Morp | 2012 |
Midazolam-ketamine combination for moderate sedation in upper GI endoscopy.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Deep | 2012 |
Analgesia and endocrine surgical stress: effect of two analgesia protocols on cortisol and prolactin levels during abdominal aortic aneurysm endovascular repair.
Topics: 17-alpha-Hydroxyprogesterone; Aged; Aged, 80 and over; Analgesics, Opioid; Aortic Aneurysm, Abdomina | 2011 |
Sevoflurane to alleviate pain on propofol injection.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Fentanyl; Humans; Injections, Intr | 2011 |
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti | 2012 |
Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation and analgesia in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Conscious Sedation; Emergency | 2011 |
Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Inhalation; Extremities | 2011 |
A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Buprenorphine; Cross-Over Studies; Double-Blin | 2012 |
Stress response and procedural pain in the preterm newborn: the role of pharmacological and non-pharmacological treatments.
Topics: Analgesics, Opioid; Biomarkers; Blood Specimen Collection; Facilitated Tucking; Female; Fentanyl; Hu | 2012 |
[Minimal dosages of fentanyl and sufentanil with bupivacaine for epidural analgesia in labor].
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Bupivacaine; Dose-Response R | 2011 |
[Three-day-type transdermal fentanyl patch conversion by rapid titration method with short-acting oral oxycodone for cancer pain].
Topics: Administration, Cutaneous; Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Drug T | 2012 |
Music during interventional radiological procedures, effect on sedation, pain and anxiety: a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anxiety; Female; Fentanyl; Humans; Hypnotics | 2012 |
Efficacy and safety of fentanyl sublingual spray for the treatment of breakthrough cancer pain: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Sublingual; Aged; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Humans; | 2012 |
[A pilot study of the reduced effects of adverse events caused by oral morphine and oxycodone after rotating to fentanyl patch in patients with metastatic breast cancer].
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Breast Neoplasms; Drug Therapy, Combin | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Intranasal fentanyl versus intravenous morphine in the emergency department treatment of severe painful sickle cell crises in children: study protocol for a randomised controlled trial.
Topics: Administration, Intranasal; Adolescent; Aerosols; Analgesics, Opioid; Anemia, Sickle Cell; Child; Ch | 2012 |
Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer.
Topics: Adolescent; Anesthesia; Anesthetics, Intravenous; Bone Marrow Examination; Child; Child, Preschool; | 2013 |
Warm water infusion during sedated colonoscopy does not decrease amount of sedation medication used.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cold Temperature; Colonoscopy; Double-Blind Method; Fema | 2012 |
Randomised trial of magnesium in the treatment of Irukandji syndrome.
Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Analysis of | 2012 |
Analgesic effect of intrathecal neostigmine combined with bupivacaine and fentanyl.
Topics: Abdomen; Adult; Analgesics; Anesthesia, Spinal; Anesthetics, Combined; Bupivacaine; Fentanyl; Hemody | 2012 |
Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Female; Fentanyl; Fibromyalgia; Hot Temperature; Humans | 2002 |
Opioid switching from morphine to transdermal fentanyl for toxicity reduction in palliative care.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cognition Disorders; | 2002 |
Pain and distress from bone marrow aspirations and lumbar punctures.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Biopsy, Needle; Bon | 2003 |
Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium.
Topics: Adjuvants, Anesthesia; Androstanols; Anesthetics, Intravenous; Anesthetics, Local; Female; Fentanyl; | 2003 |
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem | 2003 |
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem | 2003 |
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem | 2003 |
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem | 2003 |
Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind | 2003 |
Small dose bupivacaine-fentanyl spinal analgesia combined with morphine for labor.
Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Intravenous; Ane | 2003 |
Effects of fentanyl on pain and hemodynamic response after retrobulbar block in patients having phacoemulsification.
Topics: Adult; Aged; Analgesia; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Intravenous; Anesthet | 2003 |
Plasma fentanyl concentrations in awake cats and cats undergoing anesthesia and ovariohysterectomy using transdermal administration.
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthesia; Animals; Area Under Curve; Behavior, Anim | 2003 |
The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration.
Topics: Adult; Algorithms; Analgesia, Epidural; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Do | 2003 |
Women experience more pain and require more morphine than men to achieve a similar degree of analgesia.
Topics: Abdomen; Analgesics, Opioid; Anesthetics, Intravenous; Cohort Studies; Female; Fentanyl; Humans; Lin | 2003 |
Comparison of TTS-fentanyl with sustained-release oral morphine in the treatment of patients not using opioids for mild-to-moderate pain.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Analgesics, Opioid; Delayed-Action Preparatio | 2003 |
The pharmacokinetics of transdermal fentanyl delivered with and without controlled heat.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Female; Fentanyl; Hot Temperature; Humans; Mal | 2003 |
Long-term management of noncancer pain with transdermal therapeutic system-fentanyl.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Fol | 2003 |
Intraoperative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanyl.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Brain Death; Double-Blind Method; Epinephrine; Fentanyl; | 2003 |
Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life.
Topics: Acetaminophen; Activities of Daily Living; Administration, Cutaneous; Aged; Aged, 80 and over; Analg | 2004 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Use of transdermal fentanyl without prior opioid stabilization in patients with cancer pain.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Fentanyl; Gastroint | 2004 |
Pain management of cancer patients with transdermal fentanyl: a study of 1828 step I, II, & III transfers.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Follow-Up Studies; Hum | 2004 |
A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Contro | 2004 |
Transdermal fentanyl in HSCT patients: an open trial using transdermal fentanyl for the treatment of oral mucositis pain.
Topics: Administration, Cutaneous; Adult; Aged; Female; Fentanyl; Hematologic Neoplasms; Hematopoietic Stem | 2004 |
A prospective randomized comparison of extensive prostate biopsy to standard biopsy with assessment of diagnostic yield, biopsy pain and morbidity.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Biopsy; Conscious Sedation; Fentanyl; Huma | 2004 |
Intrathecal midazolam II: combination with intrathecal fentanyl for labor pain.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Drug Therapy, Combination; Female; Fentanyl; H | 2004 |
Addition of a second opioid may improve opioid response in cancer pain: preliminary data.
Topics: Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Dru | 2004 |
Patient-controlled analgesia with fentanyl for burn dressing changes.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Bandages; Burns; Double-Blind Method; Elec | 2004 |
Relative analgesic potency of fentanyl and sufentanil during intermediate-term infusions in patients after long-term opioid treatment for chronic pain.
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administra | 2004 |
A novel pain management strategy for combat casualty care.
Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Iraq; Military Personnel; Pain; Pain Mea | 2004 |
Intrathecal fentanyl-induced pruritus during labour: the effect of prophylactic ondansetron.
Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Humans; In | 2004 |
The effect of transdermal fentanyl treatment on serum cortisol concentrations in patients with non-cancer pain.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Chronic Disease; Female; Fentanyl; Humans; Hyd | 2004 |
Patient-controlled epidural analgesia in labour: the addition of fentanyl or clonidine to bupivacaine.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Blood Pressure; Bupivacaine; | 2004 |
A randomised double-blind comparison of epidural fentanyl versus fentanyl and bupivicaine for pain relief in the second stage of labour.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Combined; Anesthetics, Local; Bupiv | 2004 |
Remifentanil vs fentanyl/morphine for pain and stress control during pediatric cardiac surgery.
Topics: Analgesics, Opioid; Blood Glucose; Blood Pressure; Cardiac Surgical Procedures; Child; Child, Presch | 2004 |
Intrathecal labor analgesia using levobupivacaine 2.5 mg with fentanyl 25 microg--would half the dose suffice?
Topics: Adult; Analgesia, Obstetrical; Analgesics; Bupivacaine; Double-Blind Method; Female; Fentanyl; Human | 2004 |
Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief.
Topics: Abdomen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia Recovery Period; | 2004 |
Transdermal fentanyl for the treatment of pain caused by rheumatoid arthritis.
Topics: Administration, Cutaneous; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administrat | 2004 |
Urine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Fentany | 2004 |
Value of fentanyl in flexible sigmoidoscopy.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle Aged; Pain; Preoperative Care; Prospectiv | 2004 |
Sequential supraclavicular brachial plexus block and intravenous regional anaesthesia for upper limb surgery.
Topics: Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local | 2004 |
The effect of ketamine and fentanyl in reducing the pain of diazepam injection.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Diazepam; Double-Blind Method; Fentanyl; Hu | 2004 |
Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.
Topics: Administration, Sublingual; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Area Under Curve; | 2005 |
Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.
Topics: Administration, Sublingual; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Area Under Curve; | 2005 |
Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.
Topics: Administration, Sublingual; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Area Under Curve; | 2005 |
Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.
Topics: Administration, Sublingual; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Area Under Curve; | 2005 |
Benefits of transdermal fentanyl in patients with rheumatoid arthritis or with osteoarthritis of the knee or hip: an open-label study to assess pain control.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Arthritis, Rheumatoid; Female; Fentanyl; Humans | 2004 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
The risk of cesarean delivery with neuraxial analgesia given early versus late in labor.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Cesarean Section; Female; Fe | 2005 |
A randomized, double-blind study comparing morphine with fentanyl in prehospital analgesia.
Topics: Acute Disease; Adult; Analgesia; Analgesics, Opioid; Double-Blind Method; Emergency Medical Services | 2005 |
[The use of transdermal fentanyl in chronic non-malignant pain].
Topics: Activities of Daily Living; Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Female; | 2005 |
Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy.
Topics: Adolescent; Adult; Analgesics, Opioid; Conscious Sedation; Drug Delivery Systems; Female; Fentanyl; | 2005 |
Intra-cervical versus i.v. fentanyl for abortion.
Topics: Abortion, Induced; Adolescent; Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Cervix Uteri; Dou | 2005 |
Transdermal fentanyl for the treatment of pain caused by osteoarthritis of the knee or hip: an open, multicentre study.
Topics: Administration, Cutaneous; Analgesics, Opioid; Dose-Response Relationship, Drug; Fentanyl; Humans; M | 2005 |
The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unit.
Topics: Adult; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Conscious Sedation; Crit | 2005 |
Effectiveness of eutectic mixture of local anesthetic cream and occlusive dressing with low dosage of fentanyl for pain control during shockwave lithotripsy.
Topics: Administration, Topical; Aged; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combination; Fe | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Opioid rotation from morphine to fentanyl in delirious cancer patients: an open-label trial.
Topics: Aged; Analgesics, Opioid; Delirium; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2005 |
Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patients.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2005 |
Analgesic efficacy of pre-operative etoricoxib for termination of pregnancy in an ambulatory centre.
Topics: Abortion, Induced; Administration, Oral; Adult; Analgesics, Opioid; Cyclooxygenase Inhibitors; Doubl | 2005 |
Rapid switching between transdermal fentanyl and methadone in cancer patients.
Topics: Administration, Cutaneous; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Methadone; Middle Age | 2005 |
Switching from reservoir to matrix systems for the transdermal delivery of fentanyl: a prospective, multicenter pilot study in outpatients with chronic pain.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Chronic Disease; Female; Fentanyl; Humans; Male | 2005 |
Pain and anxiety during interventional radiologic procedures: effect of patients' state anxiety at baseline and modulation by nonpharmacologic analgesia adjuncts.
Topics: Adaptation, Psychological; Aged; Analgesia, Patient-Controlled; Analysis of Variance; Anesthetics, I | 2005 |
Prostate HDR radiation therapy: a comparative study evaluating the effectiveness of pain management with peripheral PCA vs. PCEA.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Benchmar | 2006 |
Transdermal fentanyl for improvement of pain and functioning in osteoarthritis: a randomized, placebo-controlled trial.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hum | 2006 |
[Individual aspects of the quality of life of patients with chronic pain. Observational study of treatment with fentanyl-TTS].
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Ch | 2005 |
Opioid-induced respiratory effects: new data on buprenorphine.
Topics: Analgesics, Opioid; Apnea; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Fen | 2006 |
Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1,080 pg versus oral transmucosal fentanyl citrate 1,600 pg and dose proportionality of FEBT 270 to 1,300 microg: a single-dose, randomized, open-label, three-period study in healt
Topics: Administration, Buccal; Administration, Oral; Adult; Algorithms; Analgesics, Opioid; Area Under Curv | 2006 |
A Phase III study to assess the clinical utility of low-dose fentanyl transdermal system in patients with chronic nonmalignant pain.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic D | 2006 |
Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Buprenorphine; Cold Temperature; Cross-Over St | 2006 |
Effect of local anesthesia and intravenous sedation on pain perception and vasovagal reactions during femoral arterial sheath removal after percutaneous coronary intervention.
Topics: Aged; Anesthetics, Local; Angioplasty, Balloon, Coronary; Bradycardia; Cardiovascular Diseases; Cons | 2007 |
Injectate temperature and discomfort during epidural injection.
Topics: Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Storage; Female; Fentanyl; Humans; Inject | 2006 |
Etomidate versus midazolam for procedural sedation in pediatric outpatients: a randomized controlled trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Consumer Behavior | 2006 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Dose-Response Rela | 2007 |
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-B | 2007 |
Safety and efficacy of transdermal fentanyl in patients with cancer pain: phase IV, Turkish oncology group trial.
Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Mi | 2007 |
Hemodynamic stability during labor and delivery with continuous epidural infusion.
Topics: Adult; Amides; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, | 2006 |
A double-blind comparison of a supplemental interligamentary injection of fentanyl and mepivacaine with 1:200,000 epinephrine for irreversible pulpitis.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Drug Therapy, Combination; Epine | 2007 |
[Hyperbaric bupivacaine: a randomized double-blind trial of different doses with or without fentanyl for cesarean section under spinal anesthesia].
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Dose-Response Relation | 2007 |
Impact of breakthrough pain on quality of life in patients with chronic, noncancer pain: patient perceptions and effect of treatment with oral transmucosal fentanyl citrate (OTFC, ACTIQ).
Topics: Adult; Affect; Aged; Analgesics, Opioid; Chronic Disease; Female; Fentanyl; Humans; Male; Middle Age | 2007 |
Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Ban | 2007 |
Comparison of analgesic efficacy of fentanyl and sufentanil for chest tube removal after cardiac surgery.
Topics: Adult; Aged; Analgesics, Opioid; Analysis of Variance; Blood Pressure; Cardiac Surgical Procedures; | 2007 |
Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain.
Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Child; Child, Preschool; Cross-Over Stu | 2007 |
Time-course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge.
Topics: Adult; Analgesics, Opioid; Binding, Competitive; Brain; Brain Mapping; Carbon Radioisotopes; Dopamin | 2007 |
Fentanyl buccal tablet for the relief of breakthrough pain in opioid-tolerant adult patients with chronic neuropathic pain: a multicenter, randomized, double-blind, placebo-controlled study.
Topics: Administration, Buccal; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Double-Blind M | 2007 |
Impact of an information video before colonoscopy on patient satisfaction and anxiety - a randomized trial.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anxiety; Audiovisual Aids; Colonoscopy; Con | 2007 |
Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study.
Topics: Absorption; Administration, Buccal; Adult; Aged; Analgesics, Opioid; Antineoplastic Agents; Female; | 2007 |
A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Arm Injuries; Child; Female; Fentanyl; Humans; | 2007 |
Randomized clinical trial of nebulized fentanyl citrate versus i.v. fentanyl citrate in children presenting to the emergency department with acute pain.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Analgesics, Opioid; Child; Child, Preschool; | 2007 |
A randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital setting.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Analgesics, Opioid; Emergency Medical Services; | 2007 |
Improved cancer pain treatment using combined fentanyl-TTS and tramadol.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2007 |
Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine.
Topics: Adult; Androstanols; Double-Blind Method; Female; Fentanyl; Humans; Injections, Intravenous; Lidocai | 2007 |
Analgesia for retrobulbar block--comparison of remifentanil, alfentanil and fentanyl.
Topics: Aged; Alfentanil; Analgesics, Opioid; Anesthesia, Spinal; Blood Pressure; Double-Blind Method; Femal | 2007 |
Comparison of sciatic psoas compartment block and sciatic femoral 3-in-1 block for knee arthroscopy.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Arthroscopy; Bupivacaine; Elective Surgical Pro | 2007 |
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi | 2008 |
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.
Topics: Adult; Analgesics; Brain; Brain Mapping; Carbon Radioisotopes; Culture; Female; Fentanyl; Humans; Im | 2008 |
Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Female; Fentanyl; Humans; Isoxazoles; Li | 2008 |
Comparison of the effectiveness of pretreatment by fentanyl and remifentanil on rocuronium induced injection pain.
Topics: Adult; Aged; Analgesics, Opioid; Androstanols; Double-Blind Method; Female; Fentanyl; Humans; Inject | 2008 |
Determination of fentanyl in sweat and hair of a patient using transdermal patches.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Hair; Humans | 2008 |
Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study.
Topics: Acute Disease; Administration, Intranasal; Adult; Anesthetics, Intravenous; Cross-Over Studies; Dose | 2008 |
Efficacy, safety and pharmacokinetic study of a novel fentanyl-containing matrix transdermal patch system in Japanese patients with cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Endpoint Determination; Female; Fentanyl | 2008 |
Alfentanil in minor gynaecological surgery: use with etomidate and a comparison with halothane.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Alfentanil; Ambulatory Surgical Procedures; Analgesics, Op | 1984 |
Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion.
Topics: Abortion, Induced; Adolescent; Adult; Baclofen; Clinical Trials as Topic; Diazepam; Dilatation and C | 1984 |
Effect of fentanyl and naloxone on the P300 auditory potential.
Topics: Adult; Electroencephalography; Evoked Potentials, Auditory; Female; Fentanyl; Humans; Male; Naloxone | 1984 |
Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl.
Topics: Adolescent; Adult; Aged; Anesthesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Droper | 1981 |
Masseter inhibitory periods and sensations evoked by electrical tooth pulp stimulation.
Topics: Adolescent; Adult; Dental Pulp; Electric Stimulation; Electromyography; Female; Fentanyl; Humans; Ma | 1981 |
[Epidural application of opiates in chronic pain due to malignoma (author's transl)].
Topics: Adult; Aged; Catheterization; Female; Fentanyl; Humans; Male; Meperidine; Middle Aged; Morphine; Nar | 1981 |
[Comparison between the analgesic effects of fentanyl and morphine in conscious man (author's transl)].
Topics: Female; Fentanyl; Humans; Injections, Intramuscular; Male; Morphine; Pain; Time Factors | 1980 |
Pain sensation in transurethral microwave thermotherapy for benign prostatic hyperplasia: the rationale for prophylactic sedation.
Topics: Analgesia; Conscious Sedation; Diathermy; Fentanyl; Humans; Male; Microwaves; Oxazepam; Pain; Prospe | 1994 |
Intravenous regional anesthesia using lidocaine and ketorolac.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla | 1995 |
Transdermal fentanyl: clinical development in the United States.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Drug | 1995 |
Transdermal fentanyl: a new step on the therapeutic ladder.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Bl | 1995 |
Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia.
Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics; Constipation; Dose-Response Re | 1995 |
The use of oral transmucosal fentanyl citrate for painful procedures in children.
Topics: Administration, Buccal; Adolescent; Bone Marrow Examination; Candy; Child; Child, Preschool; Conscio | 1995 |
A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain.
Topics: Adult; Affect; Cold Temperature; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fent | 1995 |
An assessment of prilocaine as a topical anaesthetic agent for fibreoptic bronchoscopy in comparison with lidocaine.
Topics: Adult; Aged; Anesthetics; Anesthetics, Local; Bronchoscopy; Conscious Sedation; Double-Blind Method; | 1994 |
Double-blind comparison of intravenous butorphanol (Stadol) and fentanyl (Sublimaze) for analgesia during labor.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Butorphanol; Double-Blind Method; Female; Fentanyl; Human | 1994 |
Oral transmucosal fentanyl citrate for premedication of children undergoing laceration repair.
Topics: Administration, Oral; Anxiety; Child; Child, Preschool; Conscious Sedation; Emergencies; Fentanyl; H | 1994 |
Is paracervical block anesthesia for oocyte retrieval effective?
Topics: Adult; Anesthesia, Spinal; Double-Blind Method; Female; Fentanyl; Humans; Multivariate Analysis; Nec | 1994 |
Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients.
Topics: Administration, Cutaneous; Administration, Oral; Fentanyl; Gastrointestinal Motility; Humans; Morphi | 1994 |
Determinants of catecholamine and cortisol responses to lower extremity revascularization. The PIRAT Study Group.
Topics: Adult; Aged; Anesthesia, Epidural; Anesthesia, General; Catecholamines; Female; Fentanyl; Humans; Hy | 1993 |
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In | 1993 |
The effects of electrical stimulation at different frequencies on perception and pain in human volunteers: epidural versus intravenous administration of fentanyl.
Topics: Adult; Analgesia; Analgesics, Opioid; Combined Modality Therapy; Cross-Over Studies; Double-Blind Me | 1996 |
Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle A | 1996 |
Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair.
Topics: Administration, Oral; Analgesics, Opioid; Child, Preschool; Chlorpromazine; Dermatologic Surgical Pr | 1996 |
A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Female; Fentany | 1996 |
Transdermal fentanyl in the management of cancer pain in ambulatory patients: an open-label pilot study.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Opioid; Fentanyl; Humans; Middle Aged; | 1996 |
Reduction of propofol pain--fentanyl vs lidocaine.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Female; F | 1996 |
Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion.
Topics: Adult; Anesthetics, Intravenous; Anxiety; Attitude of Health Personnel; Cerebrovascular Disorders; C | 1997 |
Regional brain activity changes associated with fentanyl analgesia elucidated by positron emission tomography.
Topics: Adult; Analgesics, Opioid; Brain; Cerebrovascular Circulation; Female; Fentanyl; Hot Temperature; Hu | 1997 |
Analgesia following arthroscopy--a comparison of intra-articular morphine, pethidine and fentanyl.
Topics: Acetaminophen; Adult; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; | 1997 |
Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Diazepam; Double-Blind Method; Female; Fentanyl | 1997 |
The antinociceptive effect of epidural lignocaine and fentanyl during lithotripsy.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Dose-Response Relationship, Drug; Doubl | 1997 |
A comparison of three regional anaesthesia techniques for outpatient knee arthroscopy.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Loca | 1997 |
Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients.
Topics: Adjuvants, Anesthesia; Aged; Anesthesia, Conduction; Anxiety; Arthroplasty; Cognition; Conscious Sed | 1997 |
Transdermal fentanyl for severe cancer-related pain.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle A | 1997 |
The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department.
Topics: Capnography; Carbon Dioxide; Child; Chlorpromazine; Conscious Sedation; Drug Combinations; Emergency | 1997 |
The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study.
Topics: Adult; Analgesics; Double-Blind Method; Female; Fentanyl; Humans; Injections, Intravenous; Lidocaine | 1998 |
Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response?
Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Coronary Artery Bypass; Fentan | 1997 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Consequences of inadequate analgesia during painful procedures in children.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa | 1998 |
Quality of life and cancer pain: satisfaction and side effects with transdermal fentanyl versus oral morphine.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Cross-Sectional Studies; Delayed-Action Prepara | 1998 |
Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local | 1997 |
Oral transmucosal fentanyl citrate: randomized, double-blinded, placebo-controlled trial for treatment of breakthrough pain in cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Double-Blind Method; Femal | 1998 |
Long-term treatment of cancer pain with transdermal fentanyl.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle A | 1998 |
Physiological, hormonal, and behavioral responses to a single fentanyl dose in intubated and ventilated preterm neonates.
Topics: Analgesia; Analgesics, Opioid; Blood Glucose; Catheterization, Central Venous; Double-Blind Method; | 1998 |
Effect of epidural fentanyl on neonatal respiration.
Topics: Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Infant, Newborn; Injections, Spinal; Labor, Obs | 1998 |
[Pain-free injection of propofol].
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Female; Fentanyl; Humans; Hypothermia, Induced; | 1998 |
A clinical evaluation of transdermal therapeutic system fentanyl for the treatment of cancer pain.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Evaluation | 1998 |
[Controlled analgesia in a burn patient: fentanyl sparing effect of clonidine].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesia, Patient-Controlled; Burns; Clonidine; Doubl | 1998 |
[Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine].
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Drug Combinations; Fe | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil | 1998 |
Dose-titration, multicenter study of oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients using transdermal fentanyl for persistent pain.
Topics: Administration, Buccal; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioi | 1998 |
Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Analysis of Variance; Anesth | 1998 |
Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: A randomized trial.
Topics: Analgesics, Opioid; beta-Endorphin; Catecholamines; Double-Blind Method; Fentanyl; Humans; Infant, N | 1999 |
Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia.
Topics: Amides; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Double-Blind Method; Fentanyl; | 1999 |
Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval.
Topics: Adult; Anesthesia, General; Anesthetics; Female; Fentanyl; Humans; Hypnotics and Sedatives; Isoflura | 1999 |
[Effects of speed of injection on anesthesia induction with propofol and fentanyl].
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Blood Pressure; Drug | 1999 |
A comparison of subcutaneous morphine and fentanyl in hospice cancer patients.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Injections, Sub | 1999 |
Effect of intrathecal fentanyl dose on the duration of labor analgesia.
Topics: Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Female; Fentanyl; Humans; Middle Age | 1999 |
Combined spinal-epidural analgesia in labour: comparison of two doses of intrathecal bupivacaine with fentanyl.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bupivaca | 1999 |
Effects of 3 analgesic regimens on the perception of pain after removal of femoral artery sheaths.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Angioplasty, Balloon, Coronary; Attitude to Hea | 2000 |
Comparison of combined spinal-epidural and low dose epidural for labour analgesia.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Buffers; Bupiva | 2000 |
Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Female; Fentany | 1999 |
Transdermal fentanyl in opioid-naive cancer pain patients: an open trial using transdermal fentanyl for the treatment of chronic cancer pain in opioid-naive patients and a group using codeine.
Topics: Administration, Cutaneous; Analgesics, Opioid; Codeine; Fentanyl; Humans; Neoplasms; Pain | 2000 |
Constipation and the use of laxatives: a comparison between transdermal fentanyl and oral morphine.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2000 |
Selective opiate modulation of nociceptive processing in the human brain.
Topics: Adolescent; Adult; Analgesics, Opioid; Autonomic Nervous System; Cerebrovascular Circulation; Cold T | 2000 |
[Research from the Palliative Care Department in Poznań on treatment of neoplasm pain with Durogesic (transdermal fentanyl)].
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2000 |
Comparison of fentanyl and droperidol mixture (neuroleptanalgesia II) with morphine on clinical outcomes in unstable angina patients.
Topics: Analgesics, Opioid; Angina, Unstable; Chromatography, Gas; Dopamine Antagonists; Droperidol; Drug Th | 2000 |
A randomised controlled trial of intravenous versus inhalational analgesia during outpatient oocyte recovery.
Topics: Administration, Inhalation; Adult; Analgesia; Analgesia, Patient-Controlled; Anesthetics, Inhalation | 2000 |
Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 Weeks' postconceptional Age.
Topics: Blood Specimen Collection; Cohort Studies; Dexamethasone; Electrocardiography; Facial Expression; Fe | 2001 |
Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Cros | 2001 |
Long-term observations of patients receiving transdermal fentanyl after a randomized trial.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; F | 2001 |
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Topics: Adult; Amygdala; Analgesics, Opioid; Brain; Brain Mapping; Female; Fentanyl; Humans; Magnetic Resona | 2001 |
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Topics: Adult; Amygdala; Analgesics, Opioid; Brain; Brain Mapping; Female; Fentanyl; Humans; Magnetic Resona | 2001 |
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Topics: Adult; Amygdala; Analgesics, Opioid; Brain; Brain Mapping; Female; Fentanyl; Humans; Magnetic Resona | 2001 |
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Topics: Adult; Amygdala; Analgesics, Opioid; Brain; Brain Mapping; Female; Fentanyl; Humans; Magnetic Resona | 2001 |
A randomized controlled trial of fentanyl for abortion pain.
Topics: Abortion, Induced; Adult; Analgesics, Opioid; Anxiety; Depression; Female; Fentanyl; Humans; Pain; P | 2001 |
Long-term safety of oral transmucosal fentanyl citrate for breakthrough cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Opioid; Female; F | 2001 |
Transdermal fentanyl therapy for pains in children with infantile neuronal ceroid lipofuscinosis.
Topics: Administration, Cutaneous; Analgesics, Opioid; Child; Fentanyl; Humans; Neuronal Ceroid-Lipofuscinos | 2001 |
A safe and effective method for converting cancer patients from intravenous to transdermal fentanyl.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Infusions, Int | 2001 |
Use of TTS fentanyl as a single opioid for cancer pain relief: a safety and efficacy clinical trial in patients naive to mild or strong opioids.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentan | 2002 |
Comparative study of etofenamate and fentanyl for outpatient extracorporeal shockwave lithotripsy.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; Flufenam | 2001 |
Reduction of pain on injection of propofol: a comparison of fentanyl with remifentanil.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Fentanyl; Humans; Infusions, Intravenous; Pain; Pain M | 2002 |
Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain.
Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Hydromorphone; Levorphanol; Male; Methado | 2002 |
Preoperative administration of controlled-release oxycodone for the management of pain after ambulatory laparoscopic tubal ligation surgery.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Delayed-Action Preparations; Double-Blind | 2002 |
The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol, and fentanyl.
Topics: Adult; Analgesics, Opioid; Androstanols; Anesthetics, Local; Double-Blind Method; Female; Fentanyl; | 2002 |
Sublingual fentanyl citrate for cancer-related breakthrough pain: a pilot study.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hu | 2001 |
Paracervical block and elective abortion: the effect on pain of waiting between injection and procedure.
Topics: Abortion, Induced; Analgesics, Opioid; Cervix Uteri; Female; Fentanyl; Humans; Injections; Labor Sta | 2002 |
Paracervical block and elective abortion: the effect on pain of waiting between injection and procedure.
Topics: Abortion, Induced; Analgesics, Opioid; Cervix Uteri; Female; Fentanyl; Humans; Injections; Labor Sta | 2002 |
Paracervical block and elective abortion: the effect on pain of waiting between injection and procedure.
Topics: Abortion, Induced; Analgesics, Opioid; Cervix Uteri; Female; Fentanyl; Humans; Injections; Labor Sta | 2002 |
Paracervical block and elective abortion: the effect on pain of waiting between injection and procedure.
Topics: Abortion, Induced; Analgesics, Opioid; Cervix Uteri; Female; Fentanyl; Humans; Injections; Labor Sta | 2002 |
Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations.
Topics: Dental Pulp; Double-Blind Method; Electric Stimulation; Fentanyl; Humans; Injections, Intravenous; N | 1979 |
Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia.
Topics: Adult; Anesthesia, General; Diazepam; Etomidate; Fentanyl; Humans; Imidazoles; Middle Aged; Movement | 1979 |
Effect of premedication on etomidate anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Atropine; Diazepam; Etomidate; Fentanyl; Humans; I | 1979 |
[Fentanyl prevents the pain at the site of propofol injection].
Topics: Child; Child, Preschool; Fentanyl; Humans; Injections, Intravenous; Pain; Propofol | 1992 |
[Pain control during the expulsion period in labor using bupivacaine and fentanyl].
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Drug Evaluation; Drug Therapy, Combinati | 1992 |
Transdermal fentanyl: clinical trial at the University of Colorado Health Sciences Center.
Topics: Administration, Cutaneous; Adult; Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain | 1992 |
Transdermal fentanyl: seeding trial in patients with chronic cancer pain.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Female; Fentanyl; Humans; Male; Middle Aged; Neo | 1992 |
Transdermal fentanyl for chronic cancer pain: detailed case reports and the influence of confounding factors.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Confounding Factors, Epidemiologic; Female; Fentan | 1992 |
Transdermal fentanyl use in hospice home-care patients with chronic cancer pain.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Female; Fentanyl; Home Care Services; Hospices; Hu | 1992 |
Management of cancer pain with transdermal fentanyl: phase IV trial, University of Iowa.
Topics: Administration, Cutaneous; Aged; Female; Fentanyl; Humans; Male; Middle Aged; Neoplasms; Pain | 1992 |
[Analgesic effect of transcutaneous cranial electrostimulation in patients treated by Nd:YAG laser for cancer of the rectum. A double-blind randomized trial].
Topics: Aged; Aged, 80 and over; Double-Blind Method; Electronarcosis; Female; Fentanyl; Humans; Intraoperat | 1992 |
Midazolam versus fentanyl as premedication for painful procedures in children with cancer.
Topics: Adolescent; Anxiety; Bone Marrow Examination; Child; Child, Preschool; Conscious Sedation; Double-Bl | 1992 |
Epidural fentanyl and caesarean section: when should fentanyl be given?
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Cesarean Section; Double-Blind Me | 1992 |
Segmental analgesic effect and reduction of halothane MAC from epidural fentanyl in humans.
Topics: Adult; Aged; Analgesia; Anesthesia, Epidural; Drug Interactions; Female; Fentanyl; Halothane; Humans | 1992 |
Intravenous midazolam versus fentanyl as premedication for painful procedures in pediatric oncology patients.
Topics: Adolescent; Adult; Child; Child, Preschool; Double-Blind Method; Fentanyl; Humans; Midazolam; Neopla | 1991 |
Does combined epidural lignocaine and fentanyl provide better anaesthesia for ESWL than lignocaine alone?
Topics: Anesthesia, Epidural; Double-Blind Method; Drug Combinations; Female; Fentanyl; Humans; Kidney Calcu | 1991 |
Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.
Topics: Adult; Carbon Dioxide; Fentanyl; Humans; Infusions, Intravenous; Injections, Epidural; Multiple Trau | 1991 |
Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.
Topics: Adult; Carbon Dioxide; Fentanyl; Humans; Infusions, Intravenous; Injections, Epidural; Multiple Trau | 1991 |
Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.
Topics: Adult; Carbon Dioxide; Fentanyl; Humans; Infusions, Intravenous; Injections, Epidural; Multiple Trau | 1991 |
Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.
Topics: Adult; Carbon Dioxide; Fentanyl; Humans; Infusions, Intravenous; Injections, Epidural; Multiple Trau | 1991 |
Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil.
Topics: Adolescent; Adult; Analgesics; Carbon Dioxide; Fentanyl; Humans; Pain; Respiration; Sensory Threshol | 1990 |
Continuous epidural infusion of 0.0625% bupivacaine-0.0002% fentanyl during the second stage of labor.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Delivery, Obstetric; F | 1990 |
Pain relief for outpatient colonoscopy: a comparison of alfentanil with fentanyl.
Topics: Adult; Aged; Alfentanil; Colonoscopy; Female; Fentanyl; Follow-Up Studies; Humans; Injections, Intra | 1990 |
Relaxation response in femoral angiography.
Topics: Angiography; Anxiety; Diazepam; Femoral Artery; Fentanyl; Humans; Music; Pain; Random Allocation; Re | 1990 |
Relationship between the pharmacokinetics and the analgesic and respiratory pharmacodynamics of epidural sufentanil.
Topics: Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentanyl; Humans; Injecti | 1989 |
Measurement of post-operative pain and narcotic administration in infants using a new clinical scoring system.
Topics: Fentanyl; Humans; Infant; Infant, Newborn; Pain; Pain Measurement; Postoperative Complications | 1989 |
[Significance of endocrine parameters of stress].
Topics: Adrenocorticotropic Hormone; Adult; Anesthesia, General; Clinical Trials as Topic; Coronary Artery B | 1985 |
Fentanyl and bupivacaine mixture for extradural blockade in orthopaedic surgery: effects on haemodynamic responses and pain related to the use of thigh tourniquet.
Topics: Adult; Anesthesia, Epidural; Blood Pressure; Bupivacaine; Clinical Trials as Topic; Double-Blind Met | 1987 |
[Comparative clinical studies of the hemodynamic parameters by anesthesia combination with Nalbuphin (Nubain) and Fentanyl].
Topics: Adolescent; Adult; Anesthesia, Endotracheal; Blood Pressure; Clinical Trials as Topic; Cognition; Do | 1987 |
A multiple random staircase method of psychophysical pain assessment.
Topics: Double-Blind Method; Fentanyl; Hot Temperature; Humans; Pain; Pain Measurement; Random Allocation; S | 1988 |
Simple devices in differentiating the effects of buprenorphine and fentanyl in healthy volunteers.
Topics: Adult; Blood Pressure; Buprenorphine; Female; Fentanyl; Flicker Fusion; Heart Rate; Humans; Hypnotic | 1987 |
Reliability and validity of verbal descriptor scales of painfulness.
Topics: Adolescent; Adult; Diazepam; Electric Stimulation; Female; Fentanyl; Humans; Male; Pain; Pain Measur | 1987 |
Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery.
Topics: Diazepam; Double-Blind Method; Drug Evaluation; Endorphins; Fentanyl; Humans; Intraoperative Period; | 1986 |
Prolonged antagonism of opioid action with intravenous nalmefene in man.
Topics: Adult; Drug Interactions; Fentanyl; Humans; Male; Muscle Rigidity; Naltrexone; Pain; Respiration; Ti | 1986 |
Effects of three anaesthesia methods on haemodynamic responses connected with the use of thigh tourniquet in orthopaedic patients.
Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Blood Pressure; Bupivacaine; C | 1985 |
Etomidate versus thiopental for induction of anesthesia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes | 1985 |
Alterations in response to somatic pain associated with anaesthesia. XIX: Studies with the drugs used in neuroleptanaesthesia.
Topics: Affect; Benperidol; Clinical Trials as Topic; Diazepam; Drug Synergism; Female; Fentanyl; Heroin; Hu | 1970 |
Other Studies
690 other studies available for fentanyl and Pain
| Article | Year |
|---|---|
Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.
Topics: Analgesics; Animals; Biological Availability; Drug Tolerance; Female; Glioma; Male; Mice; Mice, Inbr | 2014 |
Opioid-induced adrenal insufficiency in transdermal fentanyl treatment: a revisited diagnosis in clinical setting.
Topics: Adrenal Insufficiency; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Middle Aged; Neop | 2022 |
Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia.
Topics: Analgesia; Asphyxia Neonatorum; Fentanyl; Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemi | 2022 |
Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Fentanyl; Male; Morphine; Pain; Rats; Receptors, Opioid, del | 2022 |
Pre-hospital oral transmucosal fentanyl citrate for trauma analgesia: preliminary experience and implications for civilian mass casualty response.
Topics: Administration, Oral; Adult; Analgesia; Analgesics, Opioid; Emergency Medical Services; Female; Fent | 2022 |
Transdermal Fentanyl Usage in Working-age Patients Undergoing Cancer Treatment: Prescription Pattern Analysis Using Large Claims Data in Japan.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Japan; Male; Middle Aged; Ne | 2021 |
Inhibition of Oligodendrocyte Apoptosis in the Prelimbic Medial Prefrontal Cortex Prevents Fentanyl-induced Hyperalgesia in Rats.
Topics: Analgesics, Opioid; Animals; Apoptosis; Fentanyl; Hyperalgesia; Oligodendroglia; Pain; Prefrontal Co | 2022 |
Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology.
Topics: Fentanyl; Humans; Network Pharmacology; Pain; Signal Transduction | 2022 |
In vitro and in vivo pharmaco-dynamic study of the novel fentanyl derivatives: Acrylfentanyl, Ocfentanyl and Furanylfentanyl.
Topics: Analgesics, Opioid; Animals; beta-Arrestin 2; Fentanyl; Furans; Male; Mice; Pain; Receptors, Opioid; | 2022 |
Ketamine vs fentanyl for ED treatment of pain.
Topics: Analgesics; Analgesics, Opioid; Double-Blind Method; Fentanyl; Humans; Ketamine; Pain | 2022 |
Predicting transdermal fentanyl delivery using physics-based simulations for tailored therapy based on the age.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Fentanyl; Humans; Mid | 2022 |
Tracheostomy decreases continuous analgesia and sedation requirements.
Topics: Adult; Aged; Analgesia; Analgesics; Anti-Anxiety Agents; Endrin; Female; Fentanyl; Humans; Hypnotics | 2022 |
Safety and Efficacy of Sufentanil and Fentanyl Analgesia in Patients with Traumatic Brain Injury: A Retrospective Study.
Topics: Analgesia; Brain Injuries, Traumatic; Fentanyl; Humans; Pain; Retrospective Studies; Sufentanil | 2022 |
Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making.
Topics: Adult; Analgesics, Opioid; COVID-19; Drug Overdose; Female; Fentanyl; Humans; Male; Opiate Overdose; | 2022 |
Evaluation of opioid consumption trends for pain in Taiwan and comparison with neighboring Asian countries.
Topics: Analgesics, Opioid; Codeine; Fentanyl; Humans; Meperidine; Morphine; Pain; Taiwan | 2022 |
L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Fentanyl; Humans; Lysine; Male; Pain; Rats; Rats, Sprag | 2022 |
Atypical dermatologic manifestations in complex regional pain syndrome: a case report.
Topics: Adult; Complex Regional Pain Syndromes; Extremities; Fentanyl; Humans; Male; Pain; Pain Measurement | 2022 |
Intranasal Fentanyl for On-the-Hill Analgesia by Ski Patrol.
Topics: Administration, Intranasal; Analgesia; Analgesics; Analgesics, Opioid; Fentanyl; Humans; Naloxone; P | 2022 |
Prevalence and Perinatal Outcomes Following In Utero Exposure to Prehospital Emergency Methoxyflurane: A 17-Year Retrospective Cohort Study.
Topics: Emergency Medical Services; Female; Fentanyl; Humans; Infant, Newborn; Methoxyflurane; Pain; Pregnan | 2022 |
Effect of Transdermal Fentanyl Patch Combined with Enhanced Recovery after Surgery on the Curative Effect and Analgesic Effect of Liver Cancer.
Topics: Administration, Cutaneous; Analgesics, Opioid; Cancer Pain; Enhanced Recovery After Surgery; Fentany | 2022 |
Suspected opioid-induced hyperalgesia in an infant following surgery: A case report.
Topics: Adult; Analgesics, Opioid; Fentanyl; Humans; Hyperalgesia; Infant; Ketamine; Male; Pain | 2022 |
Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Dr | 2022 |
Trends in prehospital pain management: two decades of point-of-injury care.
Topics: Adult; Analgesics; Emergency Medical Services; Female; Fentanyl; Humans; Male; Military Personnel; M | 2022 |
Update: Correlation of Fentanyl Positive Drug Screens with other Medications in Patients from Pain, Rehabilitation and Behavioral Programs.
Topics: Analgesics, Opioid; Fentanyl; Humans; Illicit Drugs; Methamphetamine; Pain; Substance-Related Disord | 2022 |
Aloe Vera-Containing Matrix in Transdermal Fentanyl Therapy Improves Adhesion, Skin Tolerance and Quality of Life: Results of a German Multicenter Study with a New Fentanyl Patch.
Topics: Administration, Cutaneous; Aloe; Analgesics, Opioid; Fentanyl; Humans; Pain; Quality of Life; Transd | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Neoplasms | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: A Retrospective Analysis.
Topics: Aged; Analgesia; Fentanyl; Humans; Liver Neoplasms; Midazolam; Nerve Block; Pain; Retrospective Stud | 2023 |
IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Bradycardia; | 2023 |
IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Bradycardia; | 2023 |
IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Bradycardia; | 2023 |
IF IM in a crisis: Intranasal fentanyl versus intravenous morphine in adult vaso-occlusive crisis.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Bradycardia; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe.
Topics: Administration, Cutaneous; Analgesics, Opioid; Europe; Female; Fentanyl; Humans; Male; Middle Aged; | 2023 |
Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe.
Topics: Administration, Cutaneous; Analgesics, Opioid; Europe; Female; Fentanyl; Humans; Male; Middle Aged; | 2023 |
Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe.
Topics: Administration, Cutaneous; Analgesics, Opioid; Europe; Female; Fentanyl; Humans; Male; Middle Aged; | 2023 |
Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe.
Topics: Administration, Cutaneous; Analgesics, Opioid; Europe; Female; Fentanyl; Humans; Male; Middle Aged; | 2023 |
Analgesic effect of epidural anesthesia via the intervertebral foramen approach in percutaneous transforaminal endoscopic discectomy: a retrospective study.
Topics: Anesthesia, Epidural; Diskectomy; Endoscopy; Fentanyl; Humans; Intervertebral Disc Displacement; Lum | 2022 |
Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso-occlusive pain: A multicenter pediatric emergency medicine perspective.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Child; Cross-Sectional Studies; Emergency Service, Hospital | 2023 |
Oral transmucosal fentanyl citrate analgesia in prehospital trauma care: an observational cohort study.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Cohort Studies; Emergency Medical Services; Fem | 2023 |
Impact of fentanyl analgesia on the accuracy of HVPG measurements in patients with cirrhosis: a prospective, multicenter study.
Topics: Analgesia; Fentanyl; Humans; Liver Cirrhosis; Pain; Propofol; Prospective Studies | 2023 |
HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats.
Topics: Animals; Fentanyl; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; | 2023 |
Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Child; Critical Illness; Emergency Medical Services; Fent | 2023 |
Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.
Topics: Animals; Cetirizine; Fentanyl; Histamine; Histamine H1 Antagonists; Midazolam; Pain; Promethazine; R | 2023 |
An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Pain Management | 2023 |
The association of patient age, race, and demographic features on reported pain and sedation dosing during procedural abortion: A retrospective cohort study.
Topics: Abortion, Induced; Ambulatory Care Facilities; Conscious Sedation; Demography; Female; Fentanyl; Hum | 2023 |
Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs.
Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Crack Cocaine; Drug Overdose; Fentanyl; Heroin; | 2023 |
Effect of nalbuphine plus ropivacaine on vaginal labor in epidural analgesia.
Topics: Analgesia, Epidural; Female; Fentanyl; Humans; Infant, Newborn; Nalbuphine; Pain; Pregnancy; Retrosp | 2023 |
Fentanyl and the Fluorinated Fentanyl Derivative NFEPP Elicit Distinct Hydrogen-Bond Dynamics of the Opioid Receptor.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydrogen; Pain; Receptors, Opioid; Receptors, Opioid, mu | 2023 |
Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation.
Topics: Animals; Fentanyl; Freund's Adjuvant; Inflammation; Motor Activity; Pain; Rats | 2023 |
Continuous visualization and validation of pain in critically ill patients using artificial intelligence: a retrospective observational study.
Topics: Adult; Artificial Intelligence; Critical Care; Critical Illness; Fentanyl; Humans; Intensive Care Un | 2023 |
Transdermal fentanyl to parenteral morphine route switch and drug rotation in refractory cancer cachexia.
Topics: Administration, Cutaneous; Analgesics, Opioid; Cachexia; Female; Fentanyl; Humans; Morphine; Neoplas | 2022 |
Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients.
Topics: Adolescent; Age Factors; Analgesics, Opioid; Body Size; Burns; Child; Child, Preschool; Female; Fent | 2020 |
Ethnic disparities in pain processing among healthy adults: μ-opioid receptor binding potential as a putative mechanism.
Topics: Adult; Brain; Ethnicity; Female; Fentanyl; Humans; Male; Pain; Pain Threshold; Positron-Emission Tom | 2020 |
Nebulized Fentanyl for Dyspnea: A Retrospective Chart Review.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dyspnea; Female; Fen | 2020 |
[Analgesia for trauma patients in emergency medicine].
Topics: Analgesia; Emergency Medical Services; Emergency Medicine; Fentanyl; Humans; Ketamine; Pain; Pain Ma | 2020 |
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage.
Topics: Administration, Topical; Analgesics; Analgesics, Opioid; Animals; Blood Pressure; Fentanyl; Heart Ra | 2020 |
Correlation of Fentanyl Positive Drug Screens with Other Medications in Patients from Pain, Rehabilitation and Behavioral Programs.
Topics: Behavior Control; Drug Overdose; Fentanyl; Humans; Pain; Pharmaceutical Preparations; Rehabilitation | 2020 |
Influences of UGT2B7 rs7439366 and rs12233719 Polymorphisms on Fentanyl Sensitivity in Chinese Gynecologic Patients.
Topics: Adult; Alleles; Asian People; Biomarkers, Pharmacological; China; Female; Fentanyl; Gene Frequency; | 2020 |
[Analysis of Symptoms Relieved in Addition to Pain after Administration of Oxycodone or Morphine to Patients with Advanced Cancer Living at Home].
Topics: Administration, Cutaneous; Analgesics, Opioid; Cancer Pain; Fentanyl; Humans; Morphine; Neoplasms; O | 2020 |
Potential Energy Function for Fentanyl-Based Opioid Pain Killers.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Pain; Receptors, Opioid, mu | 2020 |
Improvement of Pain Relief of Fentanyl Citrate Drug Encapsulated in Nanostructured Lipid Carrier: Drug Formulation, Parameter Optimization, in vitro and in vivo Studies.
Topics: Animals; Capsules; Drug Carriers; Drug Compounding; Drug Liberation; Fentanyl; Lipids; Male; Nanostr | 2020 |
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling.
Topics: Analgesics, Opioid; Animals; Auditory Threshold; Deafness; Fentanyl; Hearing Loss; Hearing Loss, Noi | 2020 |
Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Fentanyl; Mice; Pain; Pain Measuremen | 2020 |
Fentanyl patches: Use and Misuse.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain | 2020 |
Pain management in patients with chronic kidney disease and end-stage kidney disease.
Topics: Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Hydromorphone; Kidney Failure, Chronic; Oxycodo | 2020 |
Perioperative pain control and tympanostomy tube outcomes.
Topics: Child, Preschool; Fentanyl; Humans; Infant; Ketorolac; Middle Ear Ventilation; Otitis Media with Eff | 2020 |
Divergent profiles of fentanyl withdrawal and associated pain in mice and rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Female; Fentanyl; Humans; Hyperalgesia; Locomotion; M | 2021 |
Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats.
Topics: Analgesics, Opioid; Animals; Choice Behavior; Conditioning, Operant; Drug-Seeking Behavior; Extincti | 2021 |
Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Blood Gas Analysis; Carbon Dioxide; Drug Discovery; Fentanyl | 2021 |
Preventive Analgesia, Hemodynamic Stability, and Pain in Vitreoretinal Surgery.
Topics: Analgesia; Analgesics, Opioid; Fentanyl; Hemodynamics; Humans; Pain; Pain, Postoperative; Vitreoreti | 2021 |
Pharmacological characterization of naloxegol: In vitro and in vivo studies.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Calcium; CHO Cells; Constipatio | 2021 |
Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs.
Topics: Administration, Cutaneous; Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Dogs; Fentanyl; Pa | 2021 |
Pain medication requirements in patients with opioid use disorder at the time of surgical abortion: An exploratory study.
Topics: Conscious Sedation; Female; Fentanyl; Humans; Hypnotics and Sedatives; Midazolam; Opioid-Related Dis | 2021 |
Patient satisfaction with procedural sedation in the emergency department.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Female | 2017 |
ABCB1 genotype is associated with fentanyl requirements in critically ill children.
Topics: Alleles; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; | 2017 |
A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China.
Topics: Delirium; Dexmedetomidine; Fentanyl; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Un | 2017 |
Comparison of Fentanyl Oral and Nasal Formulations #331.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Pain | 2017 |
Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Cross-Over Studies; Female; Fentanyl; Half-L | 2017 |
Variations in pediatric emergency medicine physician practices for intravenous fluid management in children with sickle cell disease and vaso-occlusive pain: A single institution experience.
Topics: Administration, Intravenous; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Child; Chil | 2018 |
Between a rock and a hard place: Prescription opioid restrictions in the time of fentanyl and other street drug adulterants.
Topics: Analgesics, Opioid; Canada; Drug Contamination; Fentanyl; Harm Reduction; Health Policy; Humans; Ill | 2017 |
Intranasal Fentanyl and Quality of Pediatric Acute Care.
Topics: Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Child; Chil | 2017 |
A case-history illustrates importance of knowledge of drug-interactions when pain-patients are prescribed non-pain drugs for co-morbidities.
Topics: Aged; Comorbidity; Diclofenac; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; F | 2017 |
Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department-With or Without Intranasal Fentanyl?
Topics: Administration, Intranasal; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Drug Therapy, Combi | 2019 |
Intranasal fentanyl improves time to analgesic delivery in sickle cell pain crises.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Female; Fentanyl; H | 2018 |
Intranasal fentanyl for acute severe pain episodes control in a dog.
Topics: Administration, Intranasal; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Pain | 2017 |
Difficulties in Pain Management Using Oxycodone and Fentanyl in Enzalutamide-Treated Patients With Advanced Prostate Cancer.
Topics: Aged; Analgesics, Opioid; Antineoplastic Agents; Benzamides; Bone Neoplasms; Drug Interactions; Fent | 2018 |
Pain Relief: Is this patient in pain or seeking a fentanyl fix.
Topics: Analgesics, Opioid; Emergency Medical Services; Fentanyl; Humans; Pain; Pain Management; Pain Measur | 2016 |
Effects of the Introduction of Intranasal Fentanyl on Reduction of Pain Severity Score in Children: An Interrupted Time-Series Analysis.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Emergency Medic | 2019 |
Pediatric emergency department triage-based pain guideline utilizing intranasal fentanyl: Effect of implementation.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentany | 2018 |
Fentanyl lozenge story part 2: from military procurement to package.
Topics: Administration, Buccal; Analgesics, Opioid; Drug Administration Schedule; Drug Packaging; Fentanyl; | 2018 |
Opioid analgesia on the battlefield: a retrospective review of data from Operation HERRICK.
Topics: Adolescent; Adult; Afghan Campaign 2001-; Afghanistan; Analgesics, Opioid; Child; Child, Preschool; | 2018 |
Doctor shopping of opioid analgesics relative to benzodiazepines: A pharmacoepidemiological study among 11.7 million inhabitants in the French countries.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Databases, Factual; Drug Prescriptions; Fentanyl; Humans | 2018 |
CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Burns; Critical Care Nursing; Female; Fentanyl; Hu | 2018 |
Antiallodynic and Antihyperalgesic Activities of Fentanyl-Loaded Dermal Clay Dressings in Rat Model of Second-Degree Burn Injury.
Topics: Animals; Bandages; Burns; Clay; Disease Models, Animal; Fentanyl; Hyperalgesia; Male; Pain; Rats; Ra | 2018 |
Transition From Continuous Infusion Fentanyl to Hydromorphone in Critically Ill Patients.
Topics: Adult; Analgesics, Opioid; Critical Care; Critical Illness; Female; Fentanyl; Humans; Hydromorphone; | 2020 |
Parenteral Opioid Shortage - Treating Pain during the Opioid-Overdose Epidemic.
Topics: Administration, Intravenous; Analgesics, Opioid; Drug Compounding; Drug Overdose; Fentanyl; Governme | 2018 |
Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test.
Topics: Activating Transcription Factor 2; Adolescent; Adult; Analgesics, Opioid; Cold Temperature; Drug Res | 2018 |
Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Sectional Studies; Drug Prescriptions; Female; Fentanyl; Geri | 2018 |
Opioid Induced Hyperalgesia with Intrathecal Infusion of High-Dose Fentanyl.
Topics: Analgesics, Opioid; Bupivacaine; Female; Fentanyl; Humans; Hyperalgesia; Infusion Pumps, Implantable | 2019 |
Taking the pain by the horns: rams and measuring tape.
Topics: Analgesia; Animals; Craniotomy; Fentanyl; Humans; Male; Nociception; Pain; Scalp; Sheep | 2018 |
Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Escape Reaction; Fentanyl; Injections | 2019 |
Assessment of prior opioid tolerance among new users of fentanyl transdermal system in FDA's Sentinel System.
Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics, Opioid; Child; Child, Preschool; Delayed-A | 2019 |
A population-based study of transdermal fentanyl initiation in Australian clinical practice.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Australia | 2019 |
Trends in the consumption of opioids for the treatment of severe pain in Europe, 1990-2016.
Topics: Analgesics, Opioid; Europe; European Union; Fentanyl; Humans; Hydromorphone; Meperidine; Morphine; O | 2019 |
Patterns and history of prescription drug use among opioid-related drug overdose cases in British Columbia, Canada, 2015-2016.
Topics: Adult; Analgesics, Opioid; British Columbia; Case-Control Studies; Drug Overdose; Female; Fentanyl; | 2019 |
Comparison of the use of different analgesics in the course of anesthesia care based on pharmacoeconomics.
Topics: Analgesics; Anesthesia; Delayed-Action Preparations; Economics, Pharmaceutical; Fentanyl; Humans; Mo | 2018 |
Effectiveness of premedication protocol using intravenous fentanyl to reduce pain associated with femoral artery closure device placement.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Endovascular Procedures; Equipment and Supplies; | 2019 |
Unusual case of transdermal fentanyl in cachexia.
Topics: Analgesics, Opioid; Cachexia; Female; Fentanyl; Hospices; Humans; Middle Aged; Naloxone; Narcotic An | 2019 |
Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects.
Topics: Analgesia; Analgesics, Opioid; Animals; beta-Arrestins; Brain; Drug Tolerance; Female; Fentanyl; Gen | 2019 |
Differences in pain treatment between surgeons and anaesthesiologists in a physician staffed prehospital emergency medical service: a retrospective cohort analysis.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Anesthesiologists; Cohort Studies; Emergency Medical Se | 2019 |
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting.
Topics: Analgesia; Analgesics, Opioid; Cost-Benefit Analysis; Female; Fentanyl; Humans; Infant, Newborn; Inf | 2019 |
Challenges of Remote Medical Care in South Sudan: Centipede Bites.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Arthropod Venoms; | 2019 |
Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity.
Topics: Analgesics, Opioid; Animals; Drug Liberation; Fentanyl; Male; Microinjections; Needles; Pain; Rats, | 2019 |
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis.
Topics: Adult; Amphetamine; Analgesics, Opioid; Anti-Bacterial Agents; C-Reactive Protein; Endocarditis; Eno | 2019 |
Comparison of the Effects of Midazolam/Fentanyl, Midazolam/Propofol, and Midazolam/Fentanyl/Propofol on Cognitive Function After Gastrointestinal Endoscopy.
Topics: Analgesics, Opioid; Cognition; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Female; Fenta | 2019 |
Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation.
Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Attitude of Health Personnel; Benzo | 2019 |
MULTIMODAL LOW-OPIOID ANESTHESIA - A NEW APPROACH TO THE ISSUE OF ADEQUATE INTRAOPERATIVE ANALGESIA.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesiology; Child; Child, Preschool; Fentanyl; Humans; Pain | 2019 |
A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Disease Models, Animal; Dose-Respon | 2013 |
Development of federally mandated risk evaluation and mitigation strategies (REMS) for transmucosal immediate-release fentanyl products.
Topics: Administration, Mucosal; Analgesics, Opioid; Fentanyl; Humans; Pain; Pharmacovigilance; Risk Managem | 2013 |
Long-term analysis of Irukandji stings in Far North Queensland.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Animals; Bathing Beaches; Bites and Stings; Child; Chil | 2013 |
A serious threat to patient safety: the unintended misuse of FentaNYL patches.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Child, Preschool; Fatal Outcome; Female; Fentan | 2013 |
Pre- and post-intervention study to assess the impact of a sedation protocol in critically ill surgical patients.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Critical Care; Critica | 2013 |
Treating pain in newborn infants: navigating between Scylla and Charybdis.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Infant, Premature, Diseases; Male; Pain; Respiration, | 2013 |
[Fentanyl: fast and furious?].
Topics: Analgesics, Opioid; Breakthrough Pain; Fentanyl; Humans; Neoplasms; Pain; Pain, Intractable | 2013 |
Fentanyl utility function: a risk-benefit composite of pain relief and breathing responses.
Topics: Adult; Analgesics, Opioid; Computer Simulation; Fentanyl; Humans; Injections, Intravenous; Male; Pai | 2013 |
Assessing the utility of the utility function.
Topics: Analgesics, Opioid; Fentanyl; Humans; Male; Pain; Respiration | 2013 |
Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese patients with cancer pain.
Topics: Aged; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Base Sequence; China; Femal | 2013 |
Sedation for interventional gastrointestinal endoscopic procedures: are we overlooking the “pain”?
Topics: Analgesia; Analgesics; Anesthetics, Combined; Endoscopy, Gastrointestinal; Female; Fentanyl; Gallsto | 2014 |
Utilization of fentanyl buccal tablets in England: exploring off-label use reported in a cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; England; Female; Fen | 2014 |
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics; | 2014 |
Pain control in patients with hepatocellular carcinoma treated by percutaneous radiofrequency ablation: comparison of the efficacy of one-shot and continuous intravenous fentanyl delivery.
Topics: Aged; Anesthetics, Intravenous; Carcinoma, Hepatocellular; Catheter Ablation; Female; Fentanyl; Huma | 2014 |
Is there an alternative to continuous opioid infusion for neonatal pain control? A preliminary report of parent/nurse-controlled analgesia in the neonatal intensive care unit.
Topics: Age Distribution; Analgesics, Opioid; Female; Fentanyl; Gestational Age; Humans; Infant; Infant, New | 2014 |
Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily D, M | 2014 |
What is your gut feeling about opioid rotation?
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Biological Availability; Delaye | 2015 |
In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Buprenorphine; Castor Oil; Constipation; Diarrhea; E | 2015 |
Glasgow Coma Scores, early opioids, and posttraumatic stress disorder among combat amputees.
Topics: Afghan Campaign 2001-; Amnesia; Amputees; Analgesics, Opioid; Comorbidity; Drug Therapy, Combination | 2014 |
Effect of intravenous general anaesthesia with epidural block on the expression of pre-endogenous opioid peptide genes.
Topics: Abdomen; Adult; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; beta-Endorphin; | 2014 |
Changes in trends and pattern of strong opioid prescribing in primary care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Cross-Sectional Studi | 2014 |
Step-up testing procedure for multiple comparisons with a control for a latent variable model with ordered categorical responses.
Topics: Algorithms; Clinical Trials as Topic; Computer Simulation; Data Interpretation, Statistical; Fentany | 2014 |
[Use of fendivia transdermal therapeutic system in Russian patients with malignant neoplasms during palliative care: pharmacoeconomic aspects].
Topics: Ambulances; Analgesics, Opioid; Cost-Benefit Analysis; Economics, Pharmaceutical; Fentanyl; Health C | 2014 |
Development, validation and application of an HPLC-MS/MS method for the determination of fentanyl and nor-fentanyl in human plasma and saliva.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fentanyl; Humans; Linear Mode | 2014 |
Chronopharmacology of analgesic effect and tolerance induced by six narcotic analgesics in mice.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Female; Fentanyl; Mic | 2015 |
A retrospective study on the influence of nutritional status on pain management in cancer patients using the transdermal fentanyl patch.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle Aged; Neo | 2014 |
Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life.
Topics: Administration, Cutaneous; Adult; Carcinoma; Chemoradiotherapy; Female; Fentanyl; Humans; Male; Midd | 2014 |
Aerosol-stable peptide-coated liposome nanoparticles: a proof-of-concept study with opioid fentanyl in enhancing analgesic effects and reducing plasma drug exposure.
Topics: Acylation; Aerosols; Analgesics, Opioid; Animals; Central Nervous System; Fentanyl; Human Umbilical | 2014 |
Medication errors related to transdermal opioid patches: lessons from a regional incident reporting system.
Topics: Adverse Drug Reaction Reporting Systems; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Medica | 2014 |
Dissociation of immunosuppressive and nociceptive effects of fentanyl, but not morphine, after repeated administration in mice: fentanyl-induced sensitization to LPS.
Topics: Analgesics; Animals; Fentanyl; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Morphine; | 2014 |
[Dynamics of indices of sympatho-adrenal system at application of a combined central sedation using alpha2a-NMDA and phentanyl].
Topics: Anesthesia, General; Anesthetics, Intravenous; Breast Neoplasms; Epinephrine; Female; Fentanyl; Huma | 2014 |
Increasing use of opioids for pain.
Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Fentanyl; Humans; Male; Morphine; Oxy | 2014 |
Relationship between onset of pain relief and patient satisfaction with fentanyl pectin nasal spray for breakthrough pain in cancer.
Topics: Administration, Intranasal; Analgesics, Opioid; Double-Blind Method; Female; Fentanyl; Humans; Male; | 2014 |
Frequent use of opioids in patients with dementia and nursing home residents: A study of the entire elderly population of Denmark.
Topics: Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Comorbidity; Cross-Sectiona | 2015 |
Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Analgesics, Opioid; Blood Chemical Ana | 2015 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2014 |
Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.
Topics: Adult; Analgesics; Cations; Cold Temperature; Female; Fentanyl; Gene Frequency; Genotype; Haplotypes | 2014 |
Clofarabine-based combination chemotherapy for relapse and refractory childhood acute lymphoblastic leukemia.
Topics: Adenine Nucleotides; Adolescent; Analgesics, Opioid; Antibiotic Prophylaxis; Antineoplastic Combined | 2014 |
Patient-controlled intranasal fentanyl analgesia: a pilot study to assess practicality and tolerability during childbirth.
Topics: Administration, Intranasal; Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; De | 2015 |
Effect of premedication regimen on infant pain and stress response to endotracheal intubation.
Topics: Analgesics, Opioid; Blood Glucose; Drug Combinations; Fentanyl; Gestational Age; Humans; Infant; Int | 2015 |
The efficacy of low-dose transdermal fentanyl in opioid-naïve cancer patients with moderate-to-severe pain.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hum | 2015 |
Influence of serum albumin levels during opioid rotation from morphine or oxycodone to fentanyl for cancer pain.
Topics: Analgesics, Opioid; Fentanyl; Humans; Morphine; Neoplasms; Oxycodone; Pain; Serum Albumin | 2014 |
[A case of recurrent colon cancer with improvement in prognosis and cancer pain after surgical intervention].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fentanyl; Humans; Male; Middle Ag | 2014 |
Expedited Delivery of Pain Medication for Long-Bone Fractures Using an Intranasal Fentanyl Clinical Pathway.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Critical Pathwa | 2015 |
Safety of deep sedation in young children with sickle cell disease: a retrospective cohort study.
Topics: Acute Chest Syndrome; Adjuvants, Anesthesia; Anemia, Sickle Cell; Child; Child, Preschool; Deep Seda | 2015 |
Renal function and symptoms/adverse effects in opioid-treated patients with cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Sectional Studies; Fentanyl; G | 2015 |
[Efficacy of a fentanyl citrate buccal tablet for esophageal cancer pain management in a patient unable to take oral medication].
Topics: Analgesics, Opioid; Carcinoma, Squamous Cell; Esophageal Neoplasms; Fatal Outcome; Fentanyl; Humans; | 2015 |
Pain Control after Total Knee Arthroplasty: Comparing Intra-Articular Local Anesthetic Injection with Femoral Nerve Block.
Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Female; Femoral Nerve; Fentanyl; Humans; | 2015 |
Fentanyl tolerance in the treatment of cancer pain: a case of successful opioid switching from fentanyl to oxycodone at a reduced equivalent dose.
Topics: Analgesics, Opioid; Drug Substitution; Fentanyl; Humans; Male; Middle Aged; Oxycodone; Pain; Pain Ma | 2015 |
Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.
Topics: Amides; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; | 2015 |
Does intranasal fentanyl provide efficient analgesia for renal colic in adults?
Topics: Administration, Intranasal; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Emerg | 2015 |
Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cognition Disorders; | 2015 |
Accuracy of using Diagnosis Procedure Combination administrative claims data for estimating the amount of opioid consumption among cancer patients in Japan.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Codeine; Drug Prescriptions; Female; Fentanyl; H | 2015 |
Pain management during radiotherapy and radiochemotherapy in oropharyngeal cancer patients: single-institution experience.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Paravertebral block decreases opioid administration without causing hypotension during transapical transcatheter aortic valve implantation.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Aortic Valve; Blood Pressure; Bupiv | 2016 |
Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of Fentanyl in Patients with Cancer.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromatography, High | 2015 |
An Assessment of Newly Identified Barriers to and Enablers for Prehospital Pediatric Pain Management.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Allied Health Personnel; Analgesics; | 2017 |
Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 2016 |
The opioid rotation ratio of strong opioids to transdermal fentanyl in cancer patients.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Admi | 2016 |
Time to opioid administration after implementation of an intranasal fentanyl protocol.
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Clinical Protoc | 2015 |
Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of Fentanyl in Patients with Cancer.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Male; Pain; Saliva | 2015 |
Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of Fentanyl in Patients with Cancer.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Male; Pain; Saliva | 2015 |
Fentanyl-Induced Neurotoxicity in Children.
Topics: Akathisia, Drug-Induced; Analgesics, Opioid; Child; Female; Fentanyl; Hallucinations; Headache; Huma | 2015 |
Response to intravenous fentanyl infusion predicts subsequent response to transdermal fentanyl.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hum | 2016 |
[Transdermal System-Buprenorphine and Fentanyl].
Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Fentanyl; Humans; Pain; Pain Management | 2015 |
[Understanding Oral and Nasal Mucosal Absorption of Fentanyl, and Rectal Absorption of Buprenorphine].
Topics: Administration, Mucosal; Administration, Oral; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; | 2015 |
Consequences of unsafe prescribing of transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain | 2016 |
[Use of Transdermal Fentanyl in a Hospital].
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hum | 2016 |
A two-year retrospective review of the determinants of pre-hospital analgesia administration by alpine helicopter emergency medical physicians to patients with isolated limb injury.
Topics: Adult; Air Ambulances; Analgesia; Analgesics; Analgesics, Opioid; Emergency Medical Services; Female | 2016 |
Are transdermal opioids contraindicated in patients at risk of suicide?
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain; Suicide | 2017 |
Reply to: are transdermal opioids contraindicated in patients at risk of suicide?
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain; Suicide | 2017 |
Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study.
Topics: Adolescent; Adult; Aged; Brain; Brain Mapping; Female; Fentanyl; Fibromyalgia; Humans; Image Process | 2016 |
[Interaction of opioid analgesics at the level of biotransformation].
Topics: Aged; Analgesics, Opioid; Biotransformation; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3 | 2016 |
Breakthrough pain: just pain?
Topics: Analgesics, Opioid; Breakthrough Pain; Fentanyl; Humans; Neoplasms; Pain; Pain Measurement | 2016 |
Emergency Department Pain Management in Adult Patients With Traumatic Injuries Before and After Implementation of a Nurse-Initiated Pain Treatment Protocol Utilizing Fentanyl for Severe Pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Emergency Service, Hospital; Female; Fentany | 2017 |
Dose and Duration of Opioid Use in Patients with Cancer and Noncancer Pain at an Outpatient Hospital Setting in Malaysia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Cross-Sectional Studies | 2017 |
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas | 2016 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain | 2016 |
Prolonged thoracic epidural analgesia for chest tube pain during pregnancy.
Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; B | 2017 |
A retrospective analysis of nebulized versus intravenous fentanyl for renal colic.
Topics: Administration, Inhalation; Administration, Intravenous; Adult; Analgesics, Opioid; Double-Blind Met | 2017 |
Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: The FAN observational study.
Topics: Adolescent; Analgesia; Anesthetics, Inhalation; Anxiety; Australia; Canada; Child; Child, Preschool; | 2017 |
Current Concepts of Phenylpiperidine Derivatives Use in the Treatment of Acute and Chronic Pain.
Topics: Analgesics; Chronic Pain; Fentanyl; Humans; Pain; Piperidines; Sufentanil | 2017 |
[Measurement of amount of fentanyl remaining in used patches: investigation of clinical factors affecting the remaining amounts in 4 patients].
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Body Mass Index; Dosage Forms; Female; Fentanyl | 2008 |
[Patient-controlled analgesia with iontophoretic fentanyl].
Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics, Opioid; Fentanyl; Humans; Iont | 2008 |
New protocol in NY.
Topics: Analgesics, Opioid; Clinical Protocols; Emergency Medical Services; Evidence-Based Medicine; Fentany | 2008 |
Fentanyl patch for stable chronic pain in children: new indication. Used fentanyl patches should be handled with care.
Topics: Administration, Cutaneous; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Chronic Disease; | 2008 |
Involvement of kappa-opioid receptors in visceral nociception in mice.
Topics: Analgesics, Opioid; Animals; Colon; Dilatation, Pathologic; Electromyography; Female; Fentanyl; Huma | 2008 |
[Perioperative management of patients with cancer-pain receiving fentanyl patch].
Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; F | 2008 |
Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Area Under Curve; Clinical Trials, Phase II as | 2008 |
Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationshi | 2008 |
Oxycodone-induced analgesic effects in a bone cancer pain model in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bone Neoplasms; Disease Models, Animal; F | 2008 |
Using pain relief patches safely.
Topics: Analgesics, Opioid; Drug Delivery Systems; Fentanyl; Humans; Pain; Safety | 2008 |
[Medicinal management of pain and symptoms following the withdrawal of treatment in babies and children].
Topics: Female; Fentanyl; Humans; Infant; Infant, Newborn; Life Support Care; Neuromuscular Agents; Neuromus | 2008 |
[Analgesics and palliative care].
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pain; Palliative C | 2008 |
Commentary on Dr. Heit and Dr. Gilson's letter to the Drug Enforcement Administration. Does your pharmacist interpret a new federal standard in a manner that can make your patient suffer in pain?
Topics: Fentanyl; Government Regulation; Humans; Legislation, Drug; Medical Errors; Pain; Prescription Drugs | 2008 |
Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Hot Temp | 2009 |
Breakthrough cancer pain.
Topics: Analgesics, Opioid; Fentanyl; Humans; Morphine; Neoplasms; Pain | 2008 |
Safety alert for fentanyl buccal tablets.
Topics: Administration, Buccal; Adverse Drug Reaction Reporting Systems; Analgesics, Opioid; Fentanyl; Human | 2008 |
Trends in opioid consumption in the Nordic countries 2002-2006.
Topics: Analgesics, Opioid; Databases, Factual; Denmark; Dextropropoxyphene; Drug Administration Routes; Dru | 2009 |
Equipotent doses to switch from high doses of opioids to transdermal buprenorphine.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug | 2009 |
Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department.
Topics: Abdominal Pain; Administration, Intranasal; Analgesics, Opioid; Arm Injuries; Child; Child, Preschoo | 2008 |
Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department.
Topics: Abdominal Pain; Administration, Intranasal; Analgesics, Opioid; Arm Injuries; Child; Child, Preschoo | 2008 |
Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department.
Topics: Abdominal Pain; Administration, Intranasal; Analgesics, Opioid; Arm Injuries; Child; Child, Preschoo | 2008 |
Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department.
Topics: Abdominal Pain; Administration, Intranasal; Analgesics, Opioid; Arm Injuries; Child; Child, Preschoo | 2008 |
Lollipops & lawsuits.
Topics: Analgesics, Opioid; Drug Labeling; Fentanyl; Humans; Marketing; Neoplasms; Pain; United States; Unit | 2007 |
Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Bandages; Burns; Choice Behavior; | 2009 |
Sticking to the safe side with fentanyl patches.
Topics: Administration, Cutaneous; Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Pain; Patient Educat | 2009 |
Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Fentanyl; Humans; Intubation, Gastroi | 2009 |
Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Fentanyl; Humans; Intubation, Gastroi | 2009 |
Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Fentanyl; Humans; Intubation, Gastroi | 2009 |
Safety of enteral naloxone for the reversal of opiate-induced constipation in the intensive care unit.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Fentanyl; Humans; Intubation, Gastroi | 2009 |
[Optimal conversion ratio of oral morphine to transdermal fentanyl patches to the cancer pain].
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2009 |
Prescription of opioids in Italy: everything, but the morphine.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Drug and Narcoti | 2009 |
Fentanyl transdermal analgesia during pregnancy and lactation.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Chronic Disease; Drug Residues; Female; Fentan | 2009 |
The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Dose-Response Relationship, Dru | 2009 |
Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia.
Topics: Adolescent; Adult; Aged; Air Ambulances; Analgesics, Opioid; Emergency Medical Services; Female; Fen | 2011 |
Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit.
Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Female; Fentanyl; Humans; Male; Methadone; Middle Ag | 2009 |
Secondary adrenal insufficiency due to opiate therapy - another differential diagnosis worth consideration.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Analgesics, Opioid; Diagnosis, Differential; Fentany | 2009 |
Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aminoquinolines; Analgesics, Opioid; Anesthetics, Local | 2009 |
The feasibility of using intravenous fentanyl as sublingual drops in the treatment of incidental pain in patients with cancer.
Topics: Adult; Aged; Anesthetics, Intravenous; Feasibility Studies; Female; Fentanyl; Humans; Infusions, Int | 2009 |
Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fentanyl; Hot | 2009 |
Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Carrageenan; Chronic Disease; Fentanyl; Hyper | 2009 |
In brief: heat and transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Delayed-Action Preparations; Drug Overdose; Fentanyl; | 2009 |
Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Drug Synergism; Female; Fentanyl; Hot Temperature; H | 2009 |
Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Fentanyl; Male; Mice; Mice, Inbred C3 | 2009 |
The use of transdermal fentanyl in cancer pain--a compliance study of outpatients in Taiwan.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Opioid; Coho | 2010 |
Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans.
Topics: Adult; Brain; Carbon Radioisotopes; Emotions; Fentanyl; Humans; Individuality; Life Change Events; M | 2009 |
Development of a liquid chromatography-isotope dilution mass spectrometry method for quantification of fentanyl in human plasma.
Topics: Analgesics, Opioid; Chromatography, Liquid; Fentanyl; Humans; Pain; Tandem Mass Spectrometry | 2010 |
[Fentanyl patch in the treatment of severe chronic pain].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Delayed-Ac | 2009 |
Modification of fentanyl analgesia by antidepressants.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Drug Administration Schedule; Drug Interactions; | 2010 |
Formulations of fentanyl for the management of pain.
Topics: Administration, Buccal; Administration, Cutaneous; Administration, Oral; Analgesia, Patient-Controll | 2010 |
Effects of Parecoxib and Fentanyl on nociception-induced cortical activity.
Topics: Action Potentials; Analgesics, Opioid; Animals; Arousal; Cerebral Cortex; Cyclooxygenase 2 Inhibitor | 2010 |
Fentanyl transdermal absorption linked to pharmacokinetic characteristics in patients undergoing palliative care.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Dose | 2010 |
Transdermal fentanyl: not ready for front line.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Meta-Analysis as Topic; Pain; Palli | 2009 |
Does the standard intravenous solution of fentanyl (50 microg/mL) administered intranasally have analgesic efficacy?
Topics: Administration, Intranasal; Adolescent; Analgesics, Opioid; Arm Injuries; Child; Child, Preschool; E | 2010 |
Reducing patient harm with the use of fentanyl transdermal system.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Fatal Outcome; Female; Fentanyl; Humans; Medica | 2009 |
The dosing frequency of sustained-release opioids and the prevalence of end-of-dose failure in cancer pain control: a Korean multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparations; Drug Administration | 2010 |
Treating stridor with opioids: a challenging case of paradoxical vocal cord movement.
Topics: Analgesics, Opioid; Anesthesia, General; Female; Fentanyl; Humans; Laryngoscopy; Middle Aged; Pain; | 2010 |
[Successful management of a patient with pain and dyspnea from bone metastasis and lymphangitis carcinomatosa after surgery for non-small cell lung cancer (NSCLC) in whom optimal dosages of transdermal fentanyl were determined by titration with fentanyl i
Topics: Administration, Cutaneous; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Dyspnea; Female; Fentanyl | 2010 |
Evaluation of analgesic effect and safety of fentanyl transdermal patch for cancer pain as the first line.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fenta | 2010 |
Intranasal fentanyl for analgesia in the paediatric emergency department.
Topics: Administration, Intranasal; Adolescent; Analgesia; Analgesics, Opioid; Child; Child, Preschool; Emer | 2010 |
The effect of treatment with fentanyl patches on pain relief and improvement in overall daily functioning in patients with postherpetic neuralgia.
Topics: Activities of Daily Living; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Female; Fenta | 2009 |
Fentanyl buccal soluble film (Onsolis) for breakthrough cancer pain.
Topics: Administration, Buccal; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; Drug Tol | 2010 |
[Drug safety problems in association with the use of opioid containing patches for the management of pain].
Topics: Administration, Cutaneous; Adult; Aged, 80 and over; Analgesics, Opioid; Drug Overdose; Drug-Related | 2010 |
Recent development in therapeutics for breakthrough pain.
Topics: Administration, Buccal; Analgesics, Opioid; Drug Administration Routes; Fentanyl; Humans; Narcotics; | 2010 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fe | 2010 |
[Home hospice care for the lung cancer patients].
Topics: Analgesics, Opioid; Dyspnea; Fentanyl; Home Care Services; Hospice Care; Humans; Lung Neoplasms; Mor | 2009 |
A small, silent, low friction, linear actuator for mechanical nociceptive testing in veterinary research.
Topics: Analgesics; Animals; Butorphanol; Cats; Dogs; Female; Fentanyl; Male; Pain; Pain Measurement; Pain T | 2010 |
Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service.
Topics: Administration, Inhalation; Administration, Intranasal; Adolescent; Adult; Aged; Ambulances; Analges | 2011 |
Canadian neonatologist practices regarding opioid use in ventilated and spontaneously breathing infants undergoing medical procedures.
Topics: Analgesics, Opioid; Canada; Fentanyl; Health Care Surveys; Humans; Infant; Infant, Newborn; Morphine | 2010 |
[Pain perception and pain therapy in premature infants].
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant; | 2010 |
The safety of flexible fibre-optic bronchoscopy and proceduralist-administered sedation: a tertiary referral centre experience.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Bronchoscopy; Conscious Sedation; Dyspnea; Femal | 2012 |
Biological rhythms of spinal-epidural labor analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioi | 2010 |
Historical perspectives and trends in the management of pain for cancer patients in oman.
Topics: Analgesics, Opioid; Fentanyl; Humans; Morphine; Neoplasms; Oman; Pain | 2010 |
[Analgesic efficacy and tolerability of a generic fentanyl patch (TTS). Results of two post-marketing surveillance studies including 850 patients].
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Dose-Respon | 2009 |
Mechanically strong geopolymers offer new possibilities in treatment of chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Compressive Strength; Delayed-Action Preparations; Fentanyl; Hu | 2010 |
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentan | 2011 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: intranasal fentanyl or diamorphine versus intravenous morphine for analgesia in adults.
Topics: Administration, Intranasal; Adult; Analgesics, Opioid; Emergency Medicine; Evidence-Based Medicine; | 2010 |
Fentanyl for breakthrough cancer pain--what's new?
Topics: Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain | 2010 |
Suicide by Duragesic transdermal fentanyl patch toxicity.
Topics: Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Pain; Suicide; Transdermal Patch | 2011 |
High-dose fentanyl patch for cancer pain of a patient with cholangiocarcinoma.
Topics: Administration, Cutaneous; Analgesics, Opioid; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholan | 2010 |
Case report. Intravenous fentanyl patient-controlled analgesia for perioperative treatment of neuropathic/ischaemic pain in haemodialysis patients: a case series.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Diabetic Neuropathies; Female; Fenta | 2010 |
Inappropriate use of high doses of transdermal fentanyl at admission to a palliative care unit.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2011 |
Transport mechanisms in oral transmucosal drug delivery: implications for pain management.
Topics: Administration, Mucosal; Administration, Oral; Adult; Algorithms; Analgesics; Biological Availabilit | 2011 |
p38 Mitogen-activated protein kinase activation by nerve growth factor in primary sensory neurons upregulates μ-opioid receptors to enhance opioid responsiveness toward better pain control.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Buprenorphine; Dose-Response Relationship, Drug; Dru | 2011 |
Multi-centre European study of breakthrough cancer pain: pain characteristics and patient perceptions of current and potential management strategies.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle Aged; Mor | 2011 |
Fentanyl intranasal. Breakthrough cancer pain: unsafe packaging.
Topics: Administration, Intranasal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain; Product Packaging | 2010 |
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice; | 2011 |
[A case of pain management using transdermal fentanyl patches for peritoneal carcinomatosis in a patient with small intestine stoma].
Topics: Administration, Cutaneous; Adult; Carcinoma; Fatal Outcome; Female; Fentanyl; Humans; Ileal Neoplasm | 2011 |
Dose conversion in opioid rotation from continuous intravenous infusion of morphine hydrochloride injection to fentanyl patch in the management of cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Drug Administration Schedule; Female; Fen | 2011 |
Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses.
Topics: Administration, Oral; Analgesics, Opioid; Cooperative Behavior; Databases, Factual; Drug Utilization | 2011 |
[Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain].
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Male; Mi | 2011 |
Acute leg pain due to iliac artery spasm during coronary angiography: an unusual consequence of an uncommon problem.
Topics: Acute Disease; Aged; Analgesics, Opioid; Coronary Angiography; Fentanyl; Humans; Iliac Artery; Leg; | 2011 |
Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone in patients with cancer pain.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Fe | 2011 |
Three-cycle fentanyl patch system contributes to stable control of plasma fentanyl concentration in gynecologic cancer pain patients.
Topics: Adenocarcinoma, Clear Cell; Administration, Cutaneous; Analgesics, Opioid; Carcinoma, Squamous Cell; | 2011 |
Attitude and knowledge of physicians about cancer pain management: young doctors of South Korea in their early career.
Topics: Adrenal Cortex Hormones; Adult; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Attitude | 2011 |
In brief: fentanyl sublingual tablets (Abstral) for breathrough cancer pain.
Topics: Administration, Sublingual; Fentanyl; Humans; Neoplasms; Pain; Tablets | 2011 |
The ITFR, impulsive tail flick reflex by short duration nociceptive stimuli.
Topics: Afferent Pathways; Animals; Electromyography; Electroshock; Fentanyl; Hot Temperature; Lasers; Male; | 2011 |
Rapid hypnosis as an anaesthesia adjunct for evacuation of postpartum vulval haematoma.
Topics: Acetaminophen; Adult; Anesthetics, Intravenous; Blood Loss, Surgical; Female; Fentanyl; Hematoma; Hu | 2011 |
Utilisation of transdermal fentanyl in Germany from 2004 to 2006.
Topics: Aged; Analgesics, Opioid; Databases, Factual; Dose-Response Relationship, Drug; Female; Fentanyl; Ge | 2012 |
Enhanced analgesic responses after preferential delivery of morphine and fentanyl to the olfactory epithelium in rats.
Topics: Administration, Intranasal; Analgesics, Opioid; Analysis of Variance; Animals; Central Nervous Syste | 2011 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug | 2012 |
Prospective, observational study of the depth of anesthesia during oocyte retrieval using a total intravenous anesthetic technique and the Bispectral index monitor.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Conscious Sedation; Female; Fentanyl; Huma | 2011 |
Disaster after the plaster. Fentanyl withdrawal symptoms in a curable hospice patient.
Topics: Aged, 80 and over; Analgesics, Opioid; Colonic Neoplasms; Drug Administration Schedule; Female; Fent | 2011 |
Inconsistencies in opioid equianalgesic ratios: clinical and research implications.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Delayed-Action Preparati | 2008 |
Fentanyl nasal spray (Lazanda) for pain.
Topics: Administration, Intranasal; Analgesics, Opioid; Drug Approval; Drug Interactions; Drug Therapy, Comb | 2011 |
The burden of endoscopic retrograde cholangiopancreatography (ERCP) performed with the patient under conscious sedation.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Female; Fentanyl; Humans; | 2012 |
Dissecting the relative contribution of central versus peripheral opioid analgesia: are the analgesic and adverse effects of opioids inseparable?
Topics: Analgesics, Opioid; Animals; Fentanyl; Loperamide; Male; Morphine; Pain; Receptors, Opioid; Spinal C | 2012 |
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.
Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, W | 2012 |
Assessment of pain in sedated and mechanically ventilated patients: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Analysis of Variance; Behavior; Cons | 2012 |
Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort.
Topics: Absorption; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Area Under Curve; Biolog | 2012 |
Role of μ-opioid system in the formation of memory of placebo responses.
Topics: Adult; Analgesics, Opioid; Brain; Female; Fentanyl; Humans; Male; Mental Recall; Neuropsychological | 2013 |
Rocky.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Neoplasm Metastasis; Ovarian Neoplasms; Pain; Pain Man | 2012 |
Safety of prehospital intravenous fentanyl for adult trauma patients.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentanyl; Follow-Up Studies; Hu | 2012 |
[Efficacy and safety of low-dose matrix-type transdermal fentanyl applied for opioid initiation].
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Neoplasms; Pain | 2012 |
Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects.
Topics: Adult; Carbon Radioisotopes; Cold Temperature; Corpus Striatum; Fentanyl; Humans; Male; Pain; Pain T | 2012 |
[Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone].
Topics: Adenosine; Adenosine Triphosphate; Analgesia; Analgesics; Animals; Dipyrone; Dose-Response Relations | 2012 |
A novel long-acting transdermal fentanyl solution for dogs. Editorial.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Delayed-Action Preparations; Dog Diseases; D | 2012 |
Utilisation of transdermal fentanyl in Germany from 2004 to 2006.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Male; Pain | 2012 |
Population pharmacokinetics of transdermal fentanyl in patients with cancer-related pain.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Cytochrome P-450 CYP3A; Dose-Response Re | 2012 |
Fentanyl (transmucosal).
Topics: Administration, Mucosal; Analgesics, Opioid; Fentanyl; Humans; Pain | 2012 |
Utilisation of transdermal fentanyl in Germany from 2004-2006 by Edeltraut Garbe and colleagues.
Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Male; Pain | 2012 |
Lozenge risks.
Topics: Chemistry, Pharmaceutical; Dental Caries; Dextrans; Female; Fentanyl; Humans; Liver Neoplasms; Narco | 2012 |
Pain management.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Fentanyl; Humans; Neoplasms; Pain; Pain Manage | 2012 |
Intranasal fentanyl in the palliative care of newborns and infants.
Topics: Administration, Intranasal; Analgesics, Opioid; Female; Fentanyl; Humans; Infant, Newborn; Infant, P | 2013 |
Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain.
Topics: Abdomen; Acupuncture Points; Analgesia; Animals; Electroacupuncture; Fentanyl; Hindlimb; Hyperalgesi | 2012 |
Safety and efficacy of oral transmucosal fentanyl citrate for prehospital pain control on the battlefield.
Topics: Administration, Mucosal; Administration, Oral; Afghanistan; Analgesics, Opioid; Analysis of Variance | 2012 |
Analgesic effect of switching from oral opioids to a once-a-day fentanyl citrate transdermal patch in patients with lung cancer.
Topics: Administration, Cutaneous; Analgesics, Opioid; Citric Acid; Fentanyl; Humans; Lung Neoplasms; Neopla | 2013 |
[2 cases of successful symptom management at home by using opioid rotation from a fentanyl preparation to a continuous subcutaneous injection of morphine hydrochloride, at a dose less than the equivalent dose based on the conversion table].
Topics: Analgesics, Opioid; Female; Fentanyl; Home Care Services; Humans; Injections, Intravenous; Male; Mid | 2012 |
Fentanyl pectin nasal spray: a novel intranasal delivery method for the treatment of breakthrough cancer pain.
Topics: Administration, Intranasal; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Carriers; Fen | 2013 |
Use of intravenous fentanyl against morphine tolerance in breakthrough cancer pain: a case series and literature review.
Topics: Analgesics, Opioid; Drug Administration Routes; Drug Tolerance; Female; Fentanyl; Humans; Male; Midd | 2014 |
Oral transmucosal fentanyl: new preparation. For breakthrough cancer pain when morphine fails.
Topics: Administration, Buccal; Administration, Oral; Adult; Analgesics, Opioid; Child; Dosage Forms; Fentan | 2002 |
[Pain therapy. Exaggerated anxiety regarding opioid administration].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anxiety; Chronic Disease; Fentanyl; Humans; Pain | 2002 |
Fentanyl-associated syndrome of inappropriate antidiuretic hormone secretion.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fatal Outcome; Female; Fentanyl; Humans; Inapp | 2002 |
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
[Fentanyl by buccal administration. Fifty to hundred times stronger than morphine against pain].
Topics: Administration, Buccal; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Monitoring; Fentanyl; Hu | 2002 |
Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET).
Topics: Adult; Area Under Curve; Brain; Capsaicin; Carbon Radioisotopes; Fentanyl; Humans; Male; Middle Aged | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic | 2002 |
The use of fentanyl and alfentanil sprays for episodic pain.
Topics: Alfentanil; Analgesics, Opioid; Fentanyl; Humans; Pain; Palliative Care | 2002 |
[Treatment of pain with opioid analgesics and the role of TTS-fentanyl (Durogesic)].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Pain | 2001 |
[Treatment of chronic pain--use of transdermal fentanyl (Durogesic TTS)].
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Fen | 2002 |
Opioid rotation in the treatment of joint pain. A review of 67 cases.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Drug Administrat | 2002 |
Intranasal fentanyl reduces acute pain in children in the emergency department: a safety and efficacy study.
Topics: Administration, Intranasal; Analgesics; Child; Child, Preschool; Emergency Service, Hospital; Fentan | 2002 |
Heat-associated increase in transdermal fentanyl absorption.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Hot Temperature; Human | 2003 |
Longitudinal follow-up of TTS-fentanyl use in patients with cancer-related pain: results of a compassionate-use study with special focus on elderly patients.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Constipation; Female; Fentanyl; Follow-Up Studi | 2002 |
Pain intensity after laseruvulopalatoplasty and tonsillectomy.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; Follow-Up Stud | 2003 |
Large-dose intravenous methotrexate-induced cutaneous toxicity: can oral magnesium oxide reduce pain?
Topics: Abdominal Neoplasms; Adolescent; Analgesics, Opioid; Antimetabolites, Antineoplastic; Burkitt Lympho | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain.
Topics: Administration, Cutaneous; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; F | 2003 |
Re: The fentanyl transdermal patch in the dying phase.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Pain; Terminal Care | 2003 |
The terminal cancer patient: effects of age, gender, and primary tumor site on opioid dose.
Topics: Age Factors; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; M | 2003 |
Pharmacokinetics of fentanyl following intravenous and transdermal administration in horses.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Area Under Curve; Cross-Over Studies; Dose-R | 2003 |
Epidural anaesthesia for pain relief in labour.
Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; | 2003 |
Transdermal fentanyl: informed prescribing is essential.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Dose-Respon | 2003 |
NEUROLEPT-ANALGESIA AS ADJUNCT TO LOCAL ANESTHESIA IN INTRAOCULAR SURGERY; A PRELIMINARY REPORT.
Topics: Adjuvants, Anesthesia; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anesthesia, Local; Antipyret | 1965 |
Procedural pain in newborns at risk for neurologic impairment.
Topics: Analgesics, Opioid; Cohort Studies; Diagnostic Tests, Routine; Drug Administration Schedule; Fentany | 2003 |
Agitated terminal delirium and association with partial opioid substitution and hydration.
Topics: Analgesics, Opioid; Delirium; Drug Administration Schedule; Female; Fentanyl; Humans; Japan; Male; M | 2003 |
Intravenous fentanyl for cancer pain: a "fast titration" protocol for the emergency room.
Topics: Adult; Aged; Analgesics, Opioid; Emergency Medical Services; Fentanyl; Humans; Injections, Intraveno | 2003 |
Initial dose cascade of TTS fentanyl with proper adjuvant medications in cancer pain.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relatio | 2003 |
A one year health economic model comparing transdermal fentanyl with sustained-release morphine in the treatment of chronic noncancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Cost-Benefit Analysis; Delayed-Action Preparations; D | 2003 |
[Usefulness of fentanyl patch in home palliative care].
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Caregivers; Female; Fentanyl; Home Care | 2003 |
Therapy switching in patients receiving long-acting opioids.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Comorbidity; Delayed-Action Preparations; Femal | 2004 |
[Use of opioids against severe cancer pain].
Topics: Analgesics, Opioid; Fentanyl; Humans; Morphine; Neoplasms; Oxycodone; Pain; Palliative Care | 2004 |
Incidence of constipation associated with long-acting opioid therapy: a comparative study.
Topics: Aged; Analgesics, Opioid; California; Constipation; Female; Fentanyl; Humans; Incidence; Male; Middl | 2004 |
The effects of transdermal fentanyl on driving, cognitive performance, and balance in patients with chronic nonmalignant pain conditions.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Automobile Driving; Chronic Disease; Cognition; | 2004 |
[Breakthrough pain--analysis and therapy. A pilot study of a new drug, transmucosal fentanyl (Actiq)].
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle Aged; | 2004 |
Electroencephalographic bicoherence is sensitive to noxious stimuli during isoflurane or sevoflurane anesthesia.
Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Electroencephalography; Female; Fentanyl; Humans; | 2004 |
Evaluation of safety and efficacy of transdermal therapeutic system-fentanyl in adult patients with gynecological cancer-related pain.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Chronic Disease; Drug Delivery Systems; Fema | 2004 |
A study of transdermal fentanyl in cancer pain at Aichi-Cancer Center.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Cancer Care Facilities; Chronic Disease; | 2004 |
Severe withdrawal from short-term transdermal fentanyl after naloxone for uremic pruritus.
Topics: Administration, Cutaneous; Analgesics, Opioid; Drug Interactions; Drug Therapy, Combination; Fentany | 2004 |
Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.
Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Dopamine; Female; Fentanyl; Loperamide; Mac | 2004 |
Oral transmucosal abuse of transdermal fentanyl.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Chronic Disease; Depressive Disorder; Drug A | 2004 |
Emergency medicine research on the front lines.
Topics: Analgesics, Opioid; Biomedical Research; Emergency Medicine; Fentanyl; Humans; Military Personnel; P | 2004 |
[Therapy of break-through pain].
Topics: Administration, Oral; Analgesics, Opioid; Biological Availability; Clinical Trials as Topic; Drug De | 2004 |
Epidural analgesia for acute symphysis pubis dysfunction in the second trimester.
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Female; Fentanyl; H | 2004 |
Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.
Topics: Acute Disease; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Fentan | 2005 |
Utilisation pattern of fentanyl transdermal system in The Netherlands.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coh | 2005 |
Transdermal fentanyl: caution in the use of high doses.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Morphine; Pain; Palliative Care; Re | 2004 |
Differences between primary somatosensory cortex- and vertex-derived somatosensory-evoked potentials in the rat.
Topics: Anesthetics; Animals; Brain Mapping; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somat | 2004 |
Patching up your pain. The transition from pill to patch has spawned products for both chronic and short-term ailments.
Topics: Administration, Cutaneous; Analgesics; Fentanyl; Humans; Lidocaine; Nonprescription Drugs; Pain | 2004 |
[Chronic pain--new patch size expands therapy spectrum].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; | 2004 |
[Paradigm change in therapy of moderate chronic opioid responsive pain. Fentanyl alternative to weak opioids].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Dise | 2004 |
Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Carrageenan; Dose-Response Relationship, Drug; Fentanyl; Mal | 2005 |
Physicians' knowledge of transdermal fentanyl.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Clinical Competence; Family Practice; Fentanyl | 2005 |
A comparison of the resources used in advanced cancer care between two different strong opioids: an analysis of naturalistic practice in the UK.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Del | 2005 |
Equipotent doses of transdermal fentanyl and transdermal buprenorphine in patients with cancer and noncancer pain: results of a retrospective cohort study.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Chroni | 2005 |
Withdrawal symptom after discontinuation of transdermal fentanyl at a daily dose of 0.6 mg.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle A | 2005 |
Principles of pain management: agents used for somatic pain.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic | 2005 |
[Clinical trials: early use of transdermal opioid therapy].
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Antirheumatic Agents; Arthritis; Chronic Disea | 2005 |
The impact of intrapartum analgesia on infant feeding.
Topics: Analgesics, Opioid; Antiemetics; Bottle Feeding; Breast Feeding; Cohort Studies; Dose-Response Relat | 2005 |
Simplifying prehospital analgesia. Why certain medications should or should not be used for pain management in the field.
Topics: Analgesics; Anesthetics, Combined; Butorphanol; Emergency Medical Services; Emergency Medical Techni | 2005 |
Fentanyl trauma analgesia use in air medical scene transports.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Air Ambulances; Analgesia; Analgesics, Opioid; Child; Ch | 2005 |
Does the use of fentanyl in epidural solutions for postthoracotomy pain management in neonates affect surgical outcome?
Topics: Adjuvants, Anesthesia; Analgesics; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Cystic Ade | 2005 |
Mini-dose titration of the transdermal fentanyl patch--a novel approach by adjusting the area of absorption.
Topics: Absorption; Administration, Cutaneous; Analgesics, Opioid; Delayed-Action Preparations; Fentanyl; Hu | 2005 |
Diclofenac pretreatment for propofol.
Topics: Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fentanyl; Humans; Mid | 2005 |
Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bone Neoplasms; Disease Models, Animal; Fentanyl; Mic | 2005 |
Opioid switch in palliative care, opioid choice by clinical need and opioid availability.
Topics: Aged; Ambulatory Care Facilities; Analgesics, Opioid; Buprenorphine; Cohort Studies; Dose-Response R | 2005 |
Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Drug Delivery Systems; Female; Fentanyl; Humans | 2005 |
Changes in the prescribed daily doses of transdermal fentanyl and transdermal buprenorphine during treatment of patients with cancer and noncancer pain in Germany: results of a retrospective cohort study.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Cohort | 2005 |
Hyperpharmacotherapy in someone you love.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anecdotes as Topic; Dementia; Drug Monitoring; Female; | 2005 |
Pain recurrence on the third day after application of a transdermal fentanyl patch.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hum | 2005 |
Rectal insertion of fentanyl patches: a new route of toxicity.
Topics: Administration, Rectal; Adult; Analgesics, Opioid; Drug Overdose; Emergency Medicine; Fentanyl; Huma | 2005 |
Rifampin reduces the analgesic effect of transdermal fentanyl.
Topics: Adenocarcinoma; Administration, Cutaneous; Aged; Analgesics, Opioid; Antibiotics, Antitubercular; Dr | 2005 |
Physicians' knowledge of transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Clinical Competence; Fentanyl; Health Knowledge, Atti | 2005 |
Physicians' knowledge of transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Clinical Competence; Fentanyl; Health Knowledge, Atti | 2005 |
Determining pain levels in patients treated with maggot debridement therapy.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; | 2005 |
[Effective pain therapy with good tolerability. New opioid administration form by transdermal patch].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; | 2005 |
Pain and anxiety: two problems, two solutions.
Topics: Adaptation, Psychological; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Anxiety; Attenti | 2005 |
Effectiveness of transdermal fentanyl patch for treatment of acute pain due to oral mucositis in patients receiving stem cell transplantation.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Leukemia; Lymphoma, Non-Hodgk | 2005 |
[Reliably pain free with a new fentanyl patch].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Pain | 2005 |
[Simple to use--superior adhesiveness].
Topics: Adhesiveness; Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Pain | 2005 |
Is the use of transdermal fentanyl inappropriate according to the WHO guidelines and the EAPC recommendations? A study of cancer patients in Italy.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Gui | 2006 |
[Pain: etiology and drug treatment].
Topics: Acute Disease; Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Noc | 2005 |
Anesthetic management of a labouring parturient with urticaria pigmentosa.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; | 2006 |
[Medico-legal aspects of the use of fentanyl patches].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Drug Overdose; Fentanyl; Germany; Hu | 2006 |
The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cold Temperat | 2006 |
LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Bile; Chromatography, Liquid; Female; Fentanyl; | 2007 |
Can fentanyl be systemically absorbed when administered vaginally? A feasibility study.
Topics: Administration, Intravaginal; Adult; Alberta; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Ad | 2006 |
[Sedation in children: how and for who?].
Topics: Alfentanil; Anesthesia, General; Child; Conscious Sedation; Contraindications; Cooperative Behavior; | 2006 |
Fentanyl patch sufficient analgesia for only one day.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Bone Neoplasms; Fentanyl; Humans; Male; Pain; P | 2006 |
Drug utilization review on a tertiary palliative care unit.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Anxiety Agents; Cost-Benefit Analysis; Drug | 2006 |
Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(alpha)-methylhistamine, on the inhibition of nociception and plasma extravasation in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Extravasation of Diagnostic and Therapeut | 2006 |
Resolution of sweating after switching from transdermal fentanyl to oral morphine sulphate.
Topics: Administration, Oral; Analgesics, Opioid; Female; Fentanyl; Humans; Hyperhidrosis; Liver Neoplasms; | 2006 |
Vertex-recorded, rather than primary somatosensory cortex-recorded, somatosensory-evoked potentials signal unpleasantness of noxious stimuli in the rat.
Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Electroencep | 2006 |
Skin reaction to both morphine and fentanyl attenuated by steroids and antihistaminics.
Topics: Aged; Analgesics, Opioid; Drug Combinations; Female; Fentanyl; Histamine H1 Antagonists; Humans; Mor | 2006 |
Patterns of dosage changes with transdermal buprenorphine and transdermal fentanyl for the treatment of noncancer and cancer pain: a retrospective data analysis in Germany.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; Dose-R | 2006 |
Economic evaluation of Durogesic in moderate to severe, nonmalignant, chronic pain in Germany.
Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine; Chronic Disease; Cost-Benefit Analysis | 2006 |
Profound pain due to propofol injection triggered severe bronchospasm in a smoker--A case report.
Topics: Albuterol; Aminophylline; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Inflammatory Agent | 2006 |
Three-cycle fentanyl patch system significantly improves pain control in gynecologic cancer.
Topics: Adenocarcinoma, Papillary; Administration, Cutaneous; Aged; Analgesics, Opioid; Female; Fentanyl; Ge | 2006 |
Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain.
Topics: Analgesics, Opioid; Animals; Apoptosis Regulatory Proteins; Calcitonin Gene-Related Peptide; Enzyme- | 2007 |
Safety and efficacy of fentanyl administered by patient controlled analgesia in children with cancer pain.
Topics: Adolescent; Anesthetics, Intravenous; Child; Female; Fentanyl; Humans; Italy; Male; Neoplasms; Pain; | 2007 |
Cephalon used improper tactics to sell drug, probe finds.
Topics: Analgesics, Opioid; Drug Industry; Drug Labeling; Fentanyl; Humans; Marketing; Neoplasms; Pain | 2006 |
Sudden deflation of a tourniquet caused by lowering of the operating table.
Topics: Blood Loss, Surgical; Equipment Design; Equipment Failure; Fentanyl; Hand; Humans; Intraoperative Co | 2007 |
Painful pemphigus vulgaris.
Topics: Administration, Cutaneous; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Fentanyl; Gabapen | 2007 |
Equianalgesic dosing of opioids.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Fentanyl; Humans; Hydromorphone; Methadone; Pa | 2006 |
Differentiating hemodynamic responses in rat primary somatosensory cortex during non-noxious and noxious electrical stimulation by optical imaging.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Cerebrovascular Circulation; Electric Stimulation; E | 2007 |
Failure of pain control using transdermal fentanyl during rifampicin treatment.
Topics: Administration, Cutaneous; Analgesics, Opioid; Antibiotics, Antitubercular; Drug Interactions; Fenta | 2007 |
Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain.
Topics: Analgesics, Opioid; Animals; Fentanyl; Freund's Adjuvant; Male; Mice; Mice, Inbred C57BL; Mice, Inbr | 2006 |
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroi | 2007 |
Comment on Koltzenburg et al.: Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. Pain 2006;126:165-74.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Buprenorphine; Cold Temperature; Cross-Over St | 2007 |
Weighing in on the off-label use of Actiq for noncancer-related pain: a recipe for success or a recipe for disaster?
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Analgesics, Opioid; Female; Fentanyl; Huma | 2007 |
Medicating "Margaret".
Topics: Advance Directives; Alzheimer Disease; Analgesics, Opioid; Antipsychotic Agents; Electroconvulsive T | 2006 |
[Transdermal fentanyl in treating severe painful mucositis caused by autologous hematopoietic stem cell transplantation].
Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics, Opioid; Antineoplastic Combined Chemothera | 2007 |
Intranasal fentanyl for acute pain: techniques to enhance efficacy.
Topics: Acute Disease; Administration, Intranasal; Adult; Analgesics, Opioid; Biological Availability; Child | 2007 |
Clinical experience with transdermal and orally administered opioids in palliative care patients--a retrospective study.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2007 |
Placebo effects on human mu-opioid activity during pain.
Topics: Analgesics, Opioid; Brain Chemistry; Carbon Radioisotopes; Fentanyl; Hot Temperature; Humans; Pain; | 2007 |
Intraoperative analgesia for day-care surgery: practice trends.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anal | 2007 |
Ultra-low dose combined spinal-epidural anaesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Combined; Ane | 2007 |
Treating cancer-related breakthrough pain: the oral transmucosal route.
Topics: Administration, Oral; Drug Administration Routes; Fentanyl; Humans; Mouth Mucosa; Neoplasms; Pain; P | 2007 |
Fentanyl in the prehospital setting.
Topics: Administration, Intranasal; Analgesics, Opioid; Emergency Medical Services; Fentanyl; Humans; Pain; | 2007 |
Fentanyl buccal tablet (Fentora) for breakthrough pain.
Topics: Administration, Buccal; Analgesics, Opioid; Drug Interactions; Fentanyl; Humans; Neoplasms; Pain; Pa | 2007 |
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats.
Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models | 2007 |
[Comparison of clinical effectiveness of thoracic epidural and intravenous patient-controlled analgesia for the treatment of rib fractures pain in intensive care unit].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesia, Patient-Controlled; Anal | 2007 |
Toward freedom from cancer pain in Japan.
Topics: Analgesics, Opioid; Drug Utilization; Fentanyl; Humans; Japan; Morphine; Neoplasms; Pain; Practice G | 2007 |
A fentanyl-based pain management protocol provides early analgesia for adult trauma patients.
Topics: Adult; Analgesia; Analgesics, Opioid; Clinical Protocols; Dose-Response Relationship, Drug; Female; | 2007 |
Opioid use in palliative care of children and young people with cancer.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Analgesics, Opioid; Child; Child, P | 2008 |
Fentanyl-induced neurotoxicity and paradoxic pain.
Topics: Aged; Analgesics, Opioid; Fatal Outcome; Female; Fentanyl; Humans; Hyperalgesia; Leiomyosarcoma; Neu | 2008 |
Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain.
Topics: Animals; beta-Endorphin; Cells, Cultured; Cyclophosphamide; Drug Tolerance; Fentanyl; Guanosine 5'-O | 2008 |
Vertebral augmentation: toward a safe and pain-free method for back pain.
Topics: Anesthetics, Intravenous; Fentanyl; Fractures, Spontaneous; Humans; Pain; Propofol; Spinal Fractures | 2008 |
Assisted sedation: a safe and easy method for pain-free percutaneous vertebroplasty.
Topics: Aged; Anesthetics, Intravenous; Conscious Sedation; Female; Fentanyl; Humans; Hypnotics and Sedative | 2008 |
Is actiq use in noncancer-related pain really "a recipe for success"?
Topics: Abnormalities, Drug-Induced; Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Pain; Pregnancy; S | 2008 |
Spontaneously breathing technique for opioid tolerance.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory | 2008 |
Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone.
Topics: Alcoholism; Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Interactions; Fentanyl; H | 2008 |
Influence of prescription benefits on reported pain in cancer patients.
Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Insurance Coverage; Male; Medicaid; Middl | 2008 |
Suppression of noxious-induced c-fos expression in the rat lumbar spinal cord by isoflurane alone or combined with fentanyl.
Topics: Analgesics; Anesthesia; Animals; Drug Therapy, Combination; Electric Stimulation; Fentanyl; Isoflura | 2008 |
Not so fast: the reformulation of fentanyl and breakthrough chronic non-cancer pain.
Topics: Analgesics, Opioid; Chronic Disease; Drug Approval; Fentanyl; Humans; Neoplasms; Opioid-Related Diso | 2008 |
Inadequate provision of postintubation anxiolysis and analgesia in the ED.
Topics: Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Cohort Studies; Emergency Service, Ho | 2008 |
Oral transmucosal fentanyl citrate--OTFC (ACTIQ) #103.
Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain | 2008 |
Unusual presentations of scorpion envenomation.
Topics: Adult; Analgesics, Opioid; Animals; Antivenins; Blood Cell Count; Blood Chemical Analysis; Echocardi | 2008 |
The effects of prior fentanyl administration and of pain on fentanyl analgesia: tolerance to and enhancement of narcotic analgesia.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Male; Pain; | 1980 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth | 1984 |
Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy.
Topics: Animals; Brain; Diprenorphine; Drug Interactions; Etorphine; Fentanyl; Morphinans; Naloxone; Pain; R | 1984 |
[Bupivacaine-fentanyl combination in obstetric epidural anesthesia. Apropos of 203 cases].
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Bupivacaine; Female; Fentanyl; Humans; I | 1984 |
Epidural fentanyl in the management of severe pain.
Topics: Catheterization; Epidural Space; Female; Fentanyl; Humans; Middle Aged; Pain; Thorax | 1984 |
Dose-response suppression of noxiously evoked activity of WDR neurons by spinally administered fentanyl.
Topics: Action Potentials; Animals; Cats; Dose-Response Relationship, Drug; Evoked Potentials; Female; Fenta | 1983 |
Aspirin in the prevention of painful intravenous injection of disoprofol (ICI35,868) and diazepam (Valium).
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics; Aspirin; Diazepam; Female; Fentanyl; Humans | 1982 |
The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Epidural Space; Female; Fentanyl; Lipids; Male; Mep | 1982 |
Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Chronic Disease; Disease Models, Animal; D | 1982 |
The effects of high-dose fentanyl on cerebral circulation and metabolism in rats.
Topics: Animals; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electroencephalograph | 1982 |
[Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients].
Topics: Adult; Aged; Anesthetics; Animals; Biological Assay; Chronic Disease; Droperidol; Endorphins; Female | 1982 |
Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs.
Topics: Adolescent; Adult; Dental Pulp; Diazepam; Double-Blind Method; Drug Evaluation; Electric Stimulation | 1982 |
[Treatment of postoperative pain by peridural analgesia: haemodynamic study (author's transl)].
Topics: Adult; Anesthesia, Epidural; Droperidol; Fentanyl; Hemodynamics; Humans; Male; Middle Aged; Pain; Po | 1981 |
Anesthetic management of whole-body hyperthermia for the treatment of cancer.
Topics: Adolescent; Adult; Aged; Anesthetics; Body Temperature; Body Temperature Regulation; Chemical and Dr | 1980 |
Postoperative pain relief by demand analgesia.
Topics: Analgesics; Computers; Feedback; Fentanyl; Humans; Infusions, Parenteral; Pain; Patient Participatio | 1980 |
Pain relief.
Topics: Administration, Buccal; Candy; Child; Fentanyl; Humans; Pain; Premedication | 1995 |
A multifactorial analysis to explain inadequate surgical analgesia after extradural block.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Anesthesia, Epidural; Anesthetics, | 1995 |
Day-to-day titration of transdermal fentanyl is unwise.
Topics: Administration, Cutaneous; Delayed-Action Preparations; Drug Monitoring; Drug Overdose; Fentanyl; Hu | 1995 |
Comfortable labor with intrathecal narcotics.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Drug Therapy, Combination; Female; Fentanyl; Humans; Inje | 1995 |
The consumption of fentanyl is increased in rats with nociceptive but not with neuropathic pain.
Topics: Analysis of Variance; Animals; Arthritis, Infectious; Central Nervous System; Choice Behavior; Fenta | 1995 |
Stimulus intensity and the comparative efficacy of mu- and kappa-opioid agonists on nociceptive spinal reflexes in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; E | 1994 |
Transdermal fentanyl.
Topics: Administration, Cutaneous; Chronic Disease; Fentanyl; Humans; Neoplasms; Pain | 1994 |
Conscious sedation of children.
Topics: Anxiety; Child; Conscious Sedation; Emergencies; Fentanyl; Humans; Midazolam; Pain | 1994 |
[Comparison of continuous extradural analgesia during labor using 0.25% bupivacaine or mixtures of 0.25% bupivacaine and fentanyl].
Topics: Adult; Analgesia, Obstetrical; Bupivacaine; Drug Therapy, Combination; Female; Fentanyl; Humans; Lab | 1994 |
Increased intracranial pressure after fentanyl administration in a child with closed head trauma.
Topics: Animals; Child; Craniocerebral Trauma; Fentanyl; Humans; Intracranial Pressure; Male; Pain; Wounds, | 1994 |
Repeat epidural analgesia and unilateral block.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Bupivacaine; Delivery, Obstetric; Female; Fentan | 1994 |
Epidural analgesia in the management of severe vaso-occlusive sickle cell crisis.
Topics: Analgesia, Epidural; Anemia, Sickle Cell; Child; Emergencies; Female; Fentanyl; Humans; Lidocaine; M | 1994 |
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery.
Topics: Adult; Arthroscopy; Fentanyl; Humans; Male; Methemoglobinemia; Methylene Blue; Midazolam; Pain; Prop | 1993 |
Intravenous abuse of transdermal fentanyl therapy in a chronic pain patient.
Topics: Administration, Cutaneous; Adult; Chronic Disease; Female; Fentanyl; Humans; Pain; Substance Abuse, | 1993 |
Dosage of transdermal fentanyl.
Topics: Administration, Cutaneous; Administration, Oral; Fentanyl; Humans; Morphine; Pain | 1993 |
Evaluation of recalcitrant pain in HIV-infected hospitalized patients.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Chronic Disease; Female; Fentanyl; HIV Infec | 1994 |
Managing pain with transdermal fentanyl.
Topics: Administration, Cutaneous; Fentanyl; Humans; Neoplasms; Pain; Therapeutic Equivalency | 1994 |
In vivo iontophoresis of fentanyl and sufentanil in rats: pharmacokinetics and acute antinociceptive effects.
Topics: Administration, Cutaneous; Animals; Electric Stimulation; Fentanyl; Iontophoresis; Male; Pain; Rats; | 1993 |
Pain corner. Duragesic.
Topics: Administration, Cutaneous; Fentanyl; Humans; Pain | 1993 |
Fentanyl transdermal system overdose secondary to cutaneous hyperthermia.
Topics: Administration, Cutaneous; Adult; Drug Overdose; Female; Fentanyl; Hot Temperature; Humans; Neoplasm | 1993 |
High transdermal fentanyl requirements in a patient with chronic cancer pain.
Topics: Administration, Cutaneous; Adult; Carcinoma, Squamous Cell; Chronic Disease; Female; Fentanyl; Human | 1993 |
Transdermal fentanyl for cancer pain. Repeated dose pharmacokinetics.
Topics: Administration, Cutaneous; Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Female; Fentanyl; Human | 1993 |
Use of transdermal fentanyl for cancer pain management.
Topics: Administration, Cutaneous; Fentanyl; Humans; Injections, Intravenous; Morphine; Neoplasms; Pain; The | 1993 |
Criteria for use of patient-controlled analgesia in adults.
Topics: Adult; Analgesia, Patient-Controlled; Fentanyl; Humans; Meperidine; Pain | 1993 |
Peds pain protocols.
Topics: Child; Conscious Sedation; Drug Combinations; Fentanyl; Humans; Midazolam; Pain; Premedication | 1993 |
Opioid-induced muscle activity: implications for managing chronic pain.
Topics: Adenocarcinoma, Mucinous; Aged; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Hyperkinesis; | 1995 |
Drug-use evaluation of transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Drug Utilization Review; Fentanyl; H | 1995 |
Methohexital infusion technique for conscious sedation.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthetics, Intravenous; Conscious Sedation; Coopera | 1996 |
Using high-dose fentanyl patches.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Lung Neoplasms; Ma | 1996 |
Regional anaesthesia for repeat Caesarean section in a patient with phantom limb pain.
Topics: Adult; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Epidural; Anesthesia, Obstetrical; An | 1996 |
Remembrance of times past: the significance of c-fos in pain.
Topics: Analgesia; Analgesics; Anesthetics, Inhalation; Animals; Biomarkers; Fentanyl; Humans; Nervous Syste | 1996 |
Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Cell Count; Fentanyl; | 1996 |
The use of propofol for sedation in the emergency department.
Topics: Adult; Aged; Analgesia; Anesthetics, Intravenous; Conscious Sedation; Emergency Service, Hospital; F | 1996 |
Analgesia and oral opioid consumption: strengths and shortcomings of methods.
Topics: Analgesics, Opioid; Animals; Fentanyl; Pain; Rats; Self Administration | 1996 |
Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys.
Topics: Analgesics; Animals; Azocines; Behavior, Animal; Benzeneacetamides; Female; Fentanyl; Hot Temperatur | 1996 |
EMLA cream for renal extracorporeal shock wave lithotripsy in ambulatory patients.
Topics: Ambulatory Care; Analgesia; Analgesics, Opioid; Anesthetics, Local; Drug Combinations; Female; Fenta | 1996 |
Fentanyl remaining in a transdermal system following three days of continuous use.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Medical Waste Disp | 1995 |
The need for analgesia in elective cholecystectomies influenced by the time of day the operation is performed.
Topics: Aged; Analgesics, Opioid; Cholecystectomy; Circadian Rhythm; Elective Surgical Procedures; Female; F | 1996 |
[Tumor pain. Fentanyl TTS: a transdermal system for tumor pain therapy].
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Pain | 1995 |
A timely change of fentanyl patch.
Topics: Administration, Cutaneous; Fentanyl; Humans; Pain; Patient Compliance; Time Factors | 1996 |
Fentanyl transdermal system. Pain management at home.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Costs; Female; F | 1997 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Aci | 1997 |
Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain.
Topics: Adenocarcinoma; Akathisia, Drug-Induced; Analgesics, Opioid; Confusion; Fentanyl; Hallucinations; Hu | 1997 |
Quicker dosage adjustment for transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Infusions, Intravenous; Pain | 1997 |
An assessment of the peripheral antinociceptive potential of remoxipride, clonidine and fentanyl in sheep using the forelimb tourniquet.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dopamine Antagonists; Drug Evalua | 1997 |
Nurses' knowledge about equianalgesia and opioid dosing.
Topics: Administration, Cutaneous; Analgesics, Opioid; Delayed-Action Preparations; Educational Measurement; | 1997 |
[Opioid intoxication. Inappropriate administration of transdermal fentanyl].
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; Humans; Male; Pain; Peripheral Nervo | 1997 |
[Conversion from peridural to transdermal opiate analgesia in abdominal tumor pain syndrome].
Topics: Adult; Analgesia, Epidural; Bupivacaine; Carcinoma, Signet Ring Cell; Colonic Neoplasms; Combined Mo | 1997 |
Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli.
Topics: Adult; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Evaluation Studies as Topic; | 1997 |
Preliminary clinical use of a patient-controlled intranasal analgesia (PCINA) device.
Topics: Acute Disease; Administration, Inhalation; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Contro | 1997 |
Case history: a step up the analgesic ladder.
Topics: Analgesics, Opioid; Breast Neoplasms; Female; Fentanyl; Humans; Middle Aged; Morphine; Pain; Quality | 1997 |
Transdermal fentanyl for chronic pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Morphine; Neoplasm | 1997 |
Balancing symptom management.
Topics: Adenocarcinoma; Administration, Cutaneous; Analgesics, Opioid; Antineoplastic Agents; Combined Modal | 1997 |
Breakthrough pain with the fentanyl patch.
Topics: Administration, Oral; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Neoplasms; Pain; Salvag | 1997 |
Cholecystokinin inhibits peripheral opioid analgesia in inflamed tissue.
Topics: Analgesics, Opioid; Animals; Cholecystokinin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzy | 1998 |
The absence of 'cross-tolerance' when switching from oral morphine to transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Delayed-Action Preparations; Drug Tolerance; Fentanyl | 1997 |
Continuous fentanyl infusion: use in severe cancer pain.
Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Fatal Outcome; Female; Fentanyl; Humans; Infusio | 1998 |
A survey of transdermal fentanyl use in a major cancer center.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Health Care Surveys; Humans; Neoplasms; Pai | 1998 |
Anesthesia for cesarean section in a pituitary dwarf.
Topics: Adult; Analgesics, Opioid; Cesarean Section; Dwarfism; Female; Fentanyl; Humans; Injections, Spinal; | 1998 |
Factors influencing quality of life in cancer patients: the role of transdermal fentanyl in the management of pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Neoplasms; Pain; Q | 1998 |
Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery.
Topics: Administration, Inhalation; Adult; Aerosols; Analgesics, Opioid; Biological Availability; Female; Fe | 1998 |
Chronic cancer pain.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Chronic Disease; Female; Fentanyl; Humans; Neo | 1998 |
Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain.
Topics: Analgesics, Opioid; Animals; Drug Evaluation; Etorphine; Fentanyl; Heroin; Infusions, Intravenous; L | 1998 |
A research-based guideline for appropriate use of transdermal fentanyl to treat chronic pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Drug Costs; Evidence-Based Medicine; | 1998 |
Prehospital fentanyl analgesia in air-transported pediatric trauma patients.
Topics: Adolescent; Air Ambulances; Analgesia; Analgesics, Opioid; Boston; Child; Child, Preschool; Clinical | 1998 |
Heat-related toxicity with the fentanyl transdermal patch.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Fentanyl; HIV Infections; Hot Temperature; Hum | 1998 |
Controlling bone pain. How to keep nausea and oversedation out of the picture.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Pain | 1998 |
The NSAID dexketoprofen trometamol is as potent as mu-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Depression, Chemical; Electri | 1999 |
Intact proprioception and control of labour pain during epidural analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bupivaca | 1999 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A | 1999 |
Effect of fentanyl and naloxone on a thalamic induced painful response in intractable epileptic patients.
Topics: Adult; Analgesics, Opioid; Electric Stimulation Therapy; Electrocardiography; Electroencephalography | 1998 |
[Prolonged antinociceptive effect of poly (DL-lactic acid)-fentanyl composites after their intrathecal injection in rats].
Topics: Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Carriers; Fentanyl; Injections, Spina | 1999 |
Calming fears, easing pain. Children's anesthesia tricky.
Topics: Anesthesia; Child; Child, Hospitalized; Child, Preschool; Clinical Trials as Topic; Drug Approval; F | 1994 |
The use of transcutaneous electrical nerve stimulation during the biliary lithotripsy procedure.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Cholelithiasis; Conscious Sedation; Female; | 1992 |
Evaluation of intraarticular opioid analgesia for the relief of articular pain in the domestic fowl.
Topics: Analgesia; Analgesics; Animals; Arthritis, Gouty; Buprenorphine; Chickens; Disease Models, Animal; F | 1999 |
Epidural analgesia for labor pain is not associated with a decreased frequency of uterine activity.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bupivaca | 1999 |
An effective way to manage breakthrough pain.
Topics: Analgesics, Opioid; Drug Therapy, Combination; Fentanyl; Humans; Male; Middle Aged; Morphine; Pain; | 1999 |
[Value of transdermal fentanyl administration in child in palliative care].
Topics: Administration, Cutaneous; Analgesics, Opioid; Brain Neoplasms; Child; Fentanyl; Humans; Male; Neopl | 1999 |
[Transdermal Phentanyl. New therapeutic option in chronic non-tumor-induced pain].
Topics: Analgesics, Opioid; Chronic Disease; Drug Therapy, Combination; Fentanyl; Humans; Morphine; Pain | 1999 |
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2000 |
SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain.
Topics: Animals; Axons; Behavior, Animal; Cell Count; Fentanyl; Frostbite; Glutamates; Hindlimb; Hyperalgesi | 2000 |
Nebulized and intranasal fentanyl in the management of cancer-related breakthrough pain.
Topics: Administration, Inhalation; Administration, Intranasal; Aged; Aged, 80 and over; Analgesics, Opioid; | 2000 |
Trends in medical use and abuse of opioid analgesics.
Topics: Analgesics, Opioid; Drug Utilization; Fentanyl; Humans; Hydromorphone; Meperidine; Morphine; Opioid- | 2000 |
Interference of pain control employing opioids in in vivo immunological experiments.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Disease Models, Animal; Dose-Response Relationship, Drug | 1999 |
Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice.
Topics: Animals; Carbamazepine; Clonidine; Desipramine; Dizocilpine Maleate; Dose-Response Relationship, Dru | 2000 |
Applications of intrathecal catheters in children.
Topics: Adenocarcinoma; Adolescent; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics | 2000 |
Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Drug Toler | 2000 |
Transdermal fentanyl: new preparation. An alternative to morphine.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Morphine; Neoplasms | 1998 |
[Conference: opioids in the treatment of chronic pain: moving into the future with Durogestic, Valencia, November 19-20, 1999].
Topics: Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Pain | 1999 |
Drugs for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2000 |
[Oral transmucosal fentanyl citrate (OTFC) in the treatment of breakthrough pain].
Topics: Administration, Oral; Analgesics, Opioid; Fentanyl; Humans; Mouth Mucosa; Neoplasms; Pain; Tablets | 2000 |
Inadvertent administration of sufentanil instead of fentanyl during sedation/analgesia in a community hospital emergency department: a report of two cases.
Topics: Accidents, Traffic; Anesthetics, Intravenous; Causality; Emergency Service, Hospital; Fentanyl; Foll | 2000 |
A pitfall to avoid when starting a patient on transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Female; Fentanyl; Humans; Middle Aged; Ovarian Neopla | 2000 |
Transdermal fentanyl for chronic pain in AIDS: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Administration, Cutaneous; Adult; Analgesics, Opioid; Chronic Di | 2001 |
Economic evaluation of the fentanyl transdermal system for the treatment of chronic moderate to severe pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Fentanyl; Health Care Costs; Humans; | 2001 |
Morphine and alternative opioids in cancer pain: the EAPC recommendations.
Topics: Administration, Oral; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Administration Schedule; F | 2001 |
Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats.
Topics: Analgesics, Opioid; Animals; Arthritis; Behavior, Animal; Chronic Disease; Fentanyl; Male; Naloxone; | 2001 |
The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Drug Therapy, Combination; Drug Tolerance; Fem | 2001 |
Oral transmucosal fentanyl and sufentanil for incident pain.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Middle Aged; Neopla | 2001 |
Re: Economic evaluation of the fentanyl transdermal system.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Cost-Benefit Analysis; Fentanyl; Hum | 2001 |
Re: Economic evaluation of fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Cost-Benefit Analysis; Fentanyl; Hum | 2001 |
Transdermal fentanyl for pain relief in a paediatric palliative care population.
Topics: Administration, Cutaneous; Adolescent; Analgesics, Opioid; Child; Child, Preschool; Female; Fentanyl | 2001 |
Fetuses, fentanyl, and the stress response: signals from the beginnings of pain?
Topics: Adult; Analgesics, Opioid; Female; Fentanyl; Fetal Diseases; Fetus; Hemodynamics; Hormones; Humans; | 2001 |
Analgesic activity and opioid receptor selectivity of stereoisomers of ohmefentanyl isothiocyanate.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; | 2001 |
Do patients prefer transdermal fentanyl or sustained-release oral morphine for treatment of chronic non-cancer pain?
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; | 2001 |
[Real day in neonatology: JALON 2001, Nancy, October 6 2001. Fentanyl-ORL 1 receptor interactions in the perinatal period: should the "principle of precaution" be applied to premature newborns?].
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Humans; Infant, Newborn; Infant, Newb | 2001 |
Opioid therapy for chronic painful conditions.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Karnofsky Performan | 2001 |
Transmucosal fentanyl in ovarian cancer.
Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Middle Aged; Ovar | 2002 |
Opioid use in chronic pain management in the Philippines.
Topics: Analgesics, Opioid; Chronic Disease; Fentanyl; Health Knowledge, Attitudes, Practice; Humans; Meperi | 2001 |
Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.
Topics: Amides; Analgesics, Opioid; Animals; Binding, Competitive; Brain; Fentanyl; Guinea Pigs; Humans; Mal | 2002 |
[New Level III opioids of the World Health Organization].
Topics: Administration, Oral; Analgesics, Opioid; Clinical Trials as Topic; Delayed-Action Preparations; Fen | 2002 |
All I have left. A daughter's dilemma.
Topics: Administration, Cutaneous; Analgesics, Opioid; Ethics, Nursing; Father-Child Relations; Fentanyl; Hu | 2002 |
Intravenous fentanyl. Out of the operating room and gaining in popularity.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Fentanyl; Humans; Infusions, Intravenous; Pain | 2002 |
Relative reinforcing effects of three opioids with different durations of action.
Topics: Alfentanil; Analgesics, Opioid; Animals; Female; Fentanyl; Injections, Intravenous; Macaca mulatta; | 2002 |
[Opioid rotation in pain therapy. Case report].
Topics: Administration, Cutaneous; Chronic Disease; Fentanyl; Humans; Hydromorphone; Injections, Subcutaneou | 2002 |
[Impact of the commercialisation of transdermic fentanyl on the home care of terminal cancer patients].
Topics: Administration, Cutaneous; Analgesics, Opioid; Commerce; Fentanyl; Home Care Services; Humans; Neopl | 2002 |
[Paliative treatment: Treatment of chronic cancer pain (ii): the use of opiates].
Topics: Administration, Cutaneous; Administration, Oral; Age Factors; Aged; Aged, 80 and over; Analgesics, O | 2002 |
Transdermal fentanyl for the management of cancer pain: a survey of 1005 patients.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Administration S | 2001 |
Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electric | 2002 |
[Staged pain therapy plan. Opioid patch for chronic pain].
Topics: Administration, Cutaneous; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Fe | 2002 |
Excruciating perineal pain after intravenous dexamethasone.
Topics: Adult; Dexamethasone; Female; Fentanyl; Follow-Up Studies; Humans; Injections, Intravenous; Male; Pa | 2002 |
Nociceptive stimulation prevents development of tolerance to narcotic analgesia.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Fentanyl; Pain; Physical Stimulation; Rats; Reaction Ti | 1978 |
Conscious sedation with intravenous drugs: a study of amnesia.
Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Anxiety; Diazepam; Drug Combinations; F | 1978 |
[Use of phentanyl with droperidol or seduxen in nitrous oxide anesthesia in patients with blood vessel diseases of the lower extremities accompanied by pain syndrome].
Topics: Adult; Anesthesia, Inhalation; Diazepam; Droperidol; Fentanyl; Humans; Middle Aged; Nitrous Oxide; P | 1979 |
[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities].
Topics: Adult; Aged; Anesthesia, Endotracheal; Diazepam; Droperidol; Drug Therapy, Combination; Fentanyl; Hu | 1979 |
Objective tests of analgesic drugs in ponies.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid | 1979 |
The effects of intravenous fentanyl, morphine and naloxone on nociceptive responses of neurones in the rat caudal medulla.
Topics: Animals; Electric Stimulation; Electroencephalography; Fentanyl; Male; Medulla Oblongata; Morphine; | 1978 |
[Evaluation of the possibilities and adequacy of central analgesia as a component of general anesthesia].
Topics: Analgesia; Anesthesia, General; Fentanyl; Heart Defects, Congenital; Humans; Pain | 1975 |
Patient-controlled analgesia with fentanyl in children.
Topics: Abdominal Pain; Analgesia, Patient-Controlled; Bone Marrow Transplantation; Child; Child, Preschool; | 1992 |
Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Fentanyl; Macaca m | 1992 |
Can midazolam diminish sufentanil analgesia in patients with major trauma? A retrospective study with 43 patients.
Topics: Adult; Analgesics; Fentanyl; Humans; Midazolam; Pain; Retrospective Studies; Sufentanil; Wounds and | 1992 |
Possible treatment for meralgia paresthetica after coronary bypass operations.
Topics: Coronary Artery Bypass; Fentanyl; Humans; Methylprednisolone; Pain; Paresthesia; Postoperative Compl | 1992 |
[Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl].
Topics: Adolescent; Adult; Aged; Child; Female; Fentanyl; Humans; Injections, Intravenous; Lidocaine; Male; | 1992 |
Transdermal fentanyl and initial dose-finding with patient-controlled analgesia in cancer pain. A pilot study with 20 terminally ill cancer patients.
Topics: Administration, Cutaneous; Adult; Aged; Analgesia; Dose-Response Relationship, Drug; Female; Fentany | 1992 |
[Intrathecal morphine therapy in children with cancer].
Topics: Bupivacaine; Child; Child, Preschool; Female; Fentanyl; Humans; Infant; Injections, Spinal; Male; Mo | 1992 |
[The antinociceptive effects of fentanyl, midazolam and clonidine and their interactions in the spinal dorsal horn].
Topics: Animals; Cats; Clonidine; Drug Combinations; Drug Synergism; Fentanyl; Injections, Spinal; Male; Mid | 1992 |
The role of the fentanyl series for pain management: novel delivery systems.
Topics: Administration, Cutaneous; Drug Delivery Systems; Fentanyl; Humans; Pain | 1992 |
Diffuse rash associated with transdermal fentanyl.
Topics: Administration, Cutaneous; Carcinoma; Drug Eruptions; Female; Fentanyl; Humans; Lung Neoplasms; Midd | 1992 |
Midazolam-fentanyl sedation in conjunction with local anesthesia during oocyte retrieval for in vitro fertilization.
Topics: Drug Therapy, Combination; Female; Fentanyl; Fertilization in Vitro; Humans; Injections, Intramuscul | 1992 |
Value of transdermal fentanyl.
Topics: Administration, Cutaneous; Fentanyl; Humans; Pain | 1992 |
Effects of perineural opioids on nerve conduction of N. suralis in man.
Topics: Adult; Anesthesia, Epidural; Anesthesiology; Endorphins; Female; Fentanyl; Humans; Injections, Epidu | 1992 |
Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine and midazolam.
Topics: Analgesia, Epidural; Animals; Catheters, Indwelling; Dose-Response Relationship, Drug; Drug Toleranc | 1991 |
Spinally mediated antinociception following intrathecal chlordiazepoxide--further evidence for a benzodiazepine spinal analgesic effect.
Topics: Analgesia, Epidural; Animals; Catheters, Indwelling; Chlordiazepoxide; Dose-Response Relationship, D | 1991 |
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy.
Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillami | 1991 |
The effects of sham and full spinalization on the systemic potency of mu- and kappa-opioids on spinal nociceptive reflexes in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1991 |
New heteroaryl derivatives of fentanyl.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Fentanyl; Pain; Rats; Structure-Activity Relatio | 1991 |
Analgesia versus sedation during Broviac catheter placement.
Topics: Blood Glucose; Blood Pressure; Catheterization; Epinephrine; Female; Fentanyl; Heart Rate; Humans; I | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; | 1991 |
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1991 |
Oral transmucosal fentanyl citrate for analgesia and sedation in the emergency department.
Topics: Administration, Oral; Adolescent; Adult; Child; Drug Evaluation; Emergencies; Female; Fentanyl; Huma | 1991 |
Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Drug Interactions; Drug Synergism; Fentanyl; | 1990 |
Profiles of opioid analgesia in humans after intravenous bolus administration: alfentanil, fentanyl and morphine compared on experimental pain.
Topics: Adult; Alfentanil; Analgesics, Opioid; Chemical Phenomena; Chemistry, Physical; Dental Pulp; Electri | 1990 |
Epidural sufentanil for cancer pain.
Topics: Aged; Analgesia, Epidural; Analgesics; Carcinoma; Fentanyl; Humans; Infusion Pumps; Male; Pain; Rect | 1990 |
On the mechanism by which midazolam causes spinally mediated analgesia.
Topics: Analgesia, Epidural; Animals; Bicuculline; Cyclazocine; Dose-Response Relationship, Drug; Electric S | 1990 |
Morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Mo | 1990 |
From the Food and Drug Administration.
Topics: Chronic Disease; Diet Fads; Dietary Fiber; Drug Combinations; Esophageal Stenosis; Fatty Alcohols; F | 1990 |
[The value of epidural analgesia in acute pancreatitis].
Topics: Analgesia, Epidural; Bupivacaine; Cardiovascular Diseases; Drug Therapy, Combination; Fentanyl; Huma | 1990 |
Reduction of pain on injection caused by propofol.
Topics: Adult; Alfentanil; Anesthesia, Intravenous; Double-Blind Method; Female; Fentanyl; Humans; Male; Pai | 1990 |
Critique of the Dornier HM3 lithotripter as a clinical algesimeter.
Topics: Analgesia, Epidural; Bupivacaine; Female; Fentanyl; Humans; Lithotripsy; Male; Pain; Pain Measuremen | 1990 |
Modulation of pain-related somatosensory evoked potentials by general anesthesia.
Topics: Adult; Anesthesia, General; Electroencephalography; Evoked Potentials, Auditory; Evoked Potentials, | 1990 |
[Study on the analgesic effect of acupuncture with opioid receptors agonist in induced arthritic rats].
Topics: Acupuncture Analgesia; Acupuncture Therapy; Animals; Arthritis; Arthritis, Experimental; Droperidol; | 1989 |
Diagnostic epidural opioid technique.
Topics: Adult; Age Factors; Aged; Analgesia, Epidural; Chronic Disease; Disability Evaluation; Female; Fenta | 1989 |
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leu | 1989 |
Spinal antinociceptive actions of mu- and kappa-opioids: the importance of stimulus intensity in determining 'selectivity' between reflexes to different modalities of noxious stimulus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1989 |
TTS-fentanyl.
Topics: Administration, Cutaneous; Fentanyl; Humans; Neoplasms; Pain | 1989 |
Poststenotic ischaemic myocardial dysfunction induced by peripheral nociceptive stimulation.
Topics: Animals; Coronary Disease; Dogs; Electric Stimulation; Female; Fentanyl; Heart; Hemodynamics; Male; | 1989 |
Epidural fentanyl and perineal pain in labour.
Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Female; Fentanyl; H | 1989 |
Anaesthetic technique and pain in the newborn.
Topics: Anesthesia; Fentanyl; Humans; Immune Tolerance; Infant, Newborn; Isoflurane; Pain | 1989 |
[Intrathecal clonidine--how does it work in spinal fentanyl analgesia in rats?].
Topics: Adaptation, Physiological; Analgesia, Epidural; Animals; Clonidine; Drug Synergism; Female; Fentanyl | 1989 |
Transdermal fentanyl for pain control in patients with cancer.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Chronic Disease; Female; Fentanyl; Humans; Male; | 1989 |
Long-term blockade of mu-opioid receptors suggests a role in control of ingestive behaviour, body weight and core temperature in the rat.
Topics: Animals; Benzomorphans; Body Temperature Regulation; Body Weight; Circadian Rhythm; Drinking Behavio | 1988 |
[Influence of analgesics and acupuncture on cAMP content in the plasma of induced arthritic rats].
Topics: Acupuncture Therapy; Animals; Arthritis; Arthritis, Experimental; Cyclic AMP; Droperidol; Electric S | 1988 |
Electrophysiologic evidence for involvement of the pituitary region in opiate analgesia.
Topics: Analgesics, Opioid; Animals; Dental Pulp; Electroencephalography; Evoked Potentials; Fentanyl; Male; | 1985 |
[Use of morphine derivatives by the systemic route in the treatment of acute pain].
Topics: Acute Disease; Alfentanil; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Infusions, Parentera | 1985 |
Alfentanil's analgesic, respiratory, and cardiovascular actions in relation to dose and plasma concentration in unanesthetized dogs.
Topics: Alfentanil; Analgesics, Opioid; Animals; Awareness; Blood Pressure; Chromatography, Gas; Dogs; Dose- | 1986 |
Enhancement by pain and stress of analgesia produced by epidural sufentanil in the rat.
Topics: Analgesics, Opioid; Animals; Fentanyl; Injections, Epidural; Male; Pain; Rats; Rats, Inbred Strains; | 1988 |
Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain.
Topics: Aged; Chronic Disease; Depression, Chemical; Fentanyl; Humans; Injections, Spinal; Middle Aged; Noci | 1989 |
A simultaneous comparison of fentanyl's analgesic effects on experimental and clinical pain.
Topics: Affect; Back Pain; Fentanyl; Hot Temperature; Humans; Pain; Perception; Sensation | 1986 |
Spinal sufentanil effects on spinal pain-transmission neurons in cats.
Topics: Animals; Cats; Drug Interactions; Female; Fentanyl; Male; Naloxone; Neurons; Pain; Spinal Cord; Sufe | 1986 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 1986 |
A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain.
Topics: Analgesia; Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazoci | 1986 |
A comparison of the effects of alfentanil applied to the spinal cord and intravenous alfentanil on noxiously evoked activity of dorsal horn neurons in the cat spinal cord.
Topics: Alfentanil; Analgesics; Animals; Cats; Evoked Potentials; Female; Fentanyl; Injections, Intravenous; | 1986 |
Dose effects of alfentanil in human analgesia.
Topics: Adult; Alfentanil; Analgesia; Dose-Response Relationship, Drug; Evoked Potentials; Fentanyl; Half-Li | 1986 |
Failure of thyrotropin releasing hormone to reverse fentanyl-flunitrazepam anesthesia in man.
Topics: Adult; Anesthesia; Arousal; Carbon Dioxide; Female; Fentanyl; Flunitrazepam; Humans; Male; Middle Ag | 1986 |
Diagnostic epidural opioid blockade and chronic pain: preliminary report.
Topics: Adult; Aged; Anesthesia, Epidural; Back Pain; Chronic Disease; Diagnosis, Differential; Female; Fent | 1985 |
Objective assessment of opioid action by facial muscle surface electromyography (SEMG).
Topics: Adult; Aged; Butorphanol; Electromyography; Evoked Potentials; Facial Muscles; Fentanyl; Humans; Mid | 1988 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin | 1988 |
Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Fentanyl; Hindlimb; Inflammation; Male; Nociceptors; Pain | 1988 |
Effects of intrathecal fentanyl and lidocaine on somatosensory-evoked potentials, the H-reflex, and clinical responses.
Topics: Electric Stimulation; Evoked Potentials, Somatosensory; Fentanyl; H-Reflex; Humans; Injections, Spin | 1988 |
Ventilatory effects of continuous epidural infusion of fentanyl.
Topics: Adult; Anesthesia, Epidural; Female; Fentanyl; Humans; Knee; Male; Pain; Time Factors; Ventilation-P | 1988 |
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male; | 1987 |
Modification of the analgesic effect and the effect on body temperature of morphine and fentanyl, included in liposomal suspensions.
Topics: Analgesics; Animals; Body Temperature; Fentanyl; Hexobarbital; Injections, Intraperitoneal; Liposome | 1986 |
Use of fentanyl for sedation of mechanically ventilated neonates.
Topics: Fentanyl; Humans; Infant, Newborn; Pain; Respiration, Artificial | 1987 |
Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Capsaicin; Ear, External; Enkephalin, Met | 1987 |
New developments in opioid drug research for alleviation of animal pain.
Topics: Analgesia; Anesthesia; Animals; Fentanyl; Immobilization; Pain; Research; Species Specificity | 1987 |
[Effects of lidocaine, meperidine or fentanyl on pain and clinical thrombophlebitis induced by intravenous diazepam].
Topics: Adult; Diazepam; Female; Fentanyl; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Lido | 1987 |
Phantom limb pain and epidural anesthesia for cesarean section.
Topics: Adult; Analgesia; Anesthesia, Epidural; Cesarean Section; Fentanyl; Humans; Opium; Pain; Phantom Lim | 1986 |
Surgical analgesia for cesarean delivery with epidural bupivacaine and fentanyl.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Apgar Score; Bupivacaine; Cesarean Section; Do | 1986 |
Failure of epidural anesthesia to prevent postoperative paralytic ileus.
Topics: Anesthesia, Epidural; Anesthesia, General; Blood Glucose; Cholecystectomy; Colon; Fentanyl; Gastroin | 1986 |
Morphine and fentanyl interactions with thiopental in relation to movement response to noxious stimulation.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Movement; Pa | 1986 |
Fentanyl and alfentanil suppress brainstem pain transmission.
Topics: Alfentanil; Animals; Brain Stem; Cats; Electric Stimulation; Evoked Potentials; Female; Fentanyl; In | 1985 |
[The influence of a lesion of the bilateral N. accumbens upon the effects of electroacupuncture on the NRM neurons].
Topics: Acupuncture Therapy; Animals; Caudate Nucleus; Electric Stimulation; Endorphins; Evoked Potentials; | 1985 |
A method for studying cutaneous pain perception and analgesia in horses.
Topics: Analgesia; Animals; Conditioning, Operant; Female; Fentanyl; Horses; Hot Temperature; Male; Narcotic | 1985 |
Fentanyl "anesthesia" in dogs.
Topics: Anesthesia, Intravenous; Animals; Dogs; Fentanyl; Pain | 1985 |
Laparoscopic tubal clip sterilization under local anesthesia.
Topics: Adult; Anesthesia, Local; Diazepam; Drug Evaluation; Fallopian Tubes; Female; Fentanyl; Humans; Lapa | 1974 |
[Value of neuroleptoanalgesia II in the treatment of pain during myocardial infarct].
Topics: Acute Disease; Adult; Aged; Droperidol; Female; Fentanyl; Humans; Male; Middle Aged; Myocardial Infa | 1974 |
[Comparative study of analgesic drugs in postoperative pain].
Topics: Aminopyrine; Analgesics; Fentanyl; Humans; Meperidine; Pain; Pentazocine; Postoperative Complication | 1972 |
Patient's views on general anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam; | 1973 |
[Clinical evaluation of dehydrobenzperidol and fentanyl].
Topics: Adult; Aged; Benperidol; Evaluation Studies as Topic; Female; Fentanyl; Humans; Injections, Intramus | 1972 |
The relationship of the anesthetic agent to postoperative analgesic requirements.
Topics: Aged; Anesthesia; Aortic Aneurysm; Cyclopropanes; Ethyl Ethers; Female; Fentanyl; Halothane; Humans; | 1969 |
Neuroleptanalgesia II in recent myocardial infarction.
Topics: Adult; Aged; Anxiety; Butyrophenones; Female; Fentanyl; Humans; Injections, Intravenous; Male; Middl | 1969 |
A comparison of neuroleptanesthesia and halothane in neurosurgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta | 1970 |
[Possibility of achieving a pain-free post-operative period following NLA II (Neuroleptoanalgesia II0].
Topics: Adolescent; Adult; Analgesia; Benperidol; Child; Fentanyl; Humans; Methods; Middle Aged; Neuroleptan | 1970 |
On the central sites for the antinociceptive action of morphine and fentanyl.
Topics: Animals; Behavior, Animal; Binding Sites; Carbon Isotopes; Cerebral Ventricles; Dental Pulp; Diencep | 1970 |
EEG frequency content related to regional blood flow of cerebral cortex in cat.
Topics: Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Fentanyl; Krypt | 1968 |
[Sensitivity to pain and pharmacological action. (Clinical and experimental studies of some pharmacological substances of common clinical use on sensitivity to pain stimuli)].
Topics: Animals; Benperidol; Fentanyl; Haloperidol; Neuroleptanalgesia; Pain; Rats; Sensation | 1968 |
[Sensitivity to pain and pharmacological action. (Clinical and experimental studies of some pharmacological substances of common clinical use of sensitivity to pain stimuli)].
Topics: Animals; Benperidol; Fentanyl; Haloperidol; Neuroleptanalgesia; Pain; Rats; Sensation | 1968 |
Some recent advances in analgesia.
Topics: Analgesics; Anesthesia, General; Benperidol; Fentanyl; Humans; Methotrimeprazine; Pain; Pentazocine | 1969 |
[Effects of phentanyl on spontaneous EEG activity, on behavioral and EEG reactivity to pain, on primary cortical potentials evoked by means of peripheral trigeminal electric stimulations in the rabbit].
Topics: Animals; Electroencephalography; Fentanyl; Pain; Rabbits | 1965 |
[Extra-operative anesthesiological importance of the drugs used in neuroleptoanalgesia].
Topics: Anesthesia; Anesthesia, Obstetrical; Benperidol; Fentanyl; Fever; Humans; Movement Disorders; Neurol | 1965 |