Page last updated: 2024-10-27

fentanyl and Fever

fentanyl has been researched along with Fever in 16 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"Although fentanyl patches (FP) designed to sustain plasma fentanyl concentrations for 3 days are used in many patients for continuous relief of moderate to severe cancer pain, there are some cases in which effective pain relief is sustained less than for 3 days, and in which plasma fentanyl concentrations rapidly decrease at the third day after the application."3.74[Measurement of amount of fentanyl remaining in used patches: investigation of clinical factors affecting the remaining amounts in 4 patients]. ( Iguchi, H; Kojima, M; Ohta, T; Yamamoto, K, 2008)
"Fever was induced each day by 150 IU/g intravenous interleukin 2."2.70Opioids inhibit febrile responses in humans, whereas epidural analgesia does not: an explanation for hyperthermia during epidural analgesia. ( Bastanmehr, H; Bjorksten, AR; Ettinger, K; Lenhardt, R; Negishi, C; Ozaki, M; Sessler, DI, 2001)
"Fentanyl ITS was equally effective when compared with morphine IV PCA for patient subpopulations (age, surgery type, and BMI)."2.44The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies. ( Damaraju, CV; Hewitt, DJ; Kershaw, P; Siccardi, M; Viscusi, ER, 2007)
"Paroxysmal autonomic instability with dystonia (PAID) is an underdiagnosed syndrome that describes a collection of symptoms following diverse cerebral insults, such as traumatic brain injury, hydrocephalus, hemorrhagic stroke, or brain anoxia."1.56Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report. ( Baik, SW; Kang, DH; Kim, GW, 2020)
"Flurbiprofen axetil was used for slight postoperative fever."1.35[Perioperative anesthetic management of a patient with multiple sclerosis]. ( Hirose, M; Ishimoto, M; Matsuki, Y; Nobukawa, Y; Okada, A; Shigemi, K; Shimizu, K; Tabata, M; Tsugita, K; Ueda, M, 2009)
"We present two cases of scorpion envenomation with different and rare clinical situations with a short review of the literature."1.35Unusual presentations of scorpion envenomation. ( Demir, M; Ranu Alpay, N; Satar, S; Sebe, A; Topal, M, 2008)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's1 (6.25)18.2507
2000's9 (56.25)29.6817
2010's1 (6.25)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Seiler, FA1
Scavone, BM1
Shahul, S1
Arnolds, DE1
Baik, SW1
Kang, DH1
Kim, GW1
Voruz, F1
Leuchter, I1
Savić Vujović, KR1
Vučković, S1
Srebro, D1
Ivanović, M1
Došen-Mićović, L1
Vučetić, Č1
Džoljić, E1
Prostran, M1
Yamamoto, K1
Kojima, M1
Iguchi, H1
Ohta, T1
Okada, A1
Hirose, M1
Shimizu, K1
Tsugita, K1
Matsuki, Y1
Nobukawa, Y1
Tabata, M1
Ishimoto, M1
Ueda, M1
Shigemi, K1
Brown, T1
Cao, WH1
Morrison, SF1
Phadke, A1
Broadman, LM1
Brandom, BW1
Ozolek, J1
Davis, PJ1
Viscusi, ER1
Siccardi, M1
Damaraju, CV1
Hewitt, DJ1
Kershaw, P1
Ranu Alpay, N1
Satar, S1
Sebe, A1
Demir, M1
Topal, M1
Lees, DE1
Kim, YD1
Bull, JM1
Whang-Peng, J1
Schuette, W1
Smith, R1
Macnamara, TE1
Leung, WK1
Jahr, JS1
Hotz, J1
Pollock, M1
Caulkett, NA1
Cribb, PH1
Haigh, JC1
Negishi, C1
Lenhardt, R1
Ozaki, M1
Ettinger, K1
Bastanmehr, H1
Bjorksten, AR1
Sessler, DI1
Fava, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open Label Evaluation of the Safety and Clinical Utility of the Active, Separated System With Enhanced Controller (SSEC) Fentanyl 40 mcg for the Management of Acute Postoperative Pain in Pediatric Patients 12 to Less Than 18 Years of Age[NCT02395653]Phase 371 participants (Actual)Interventional2015-06-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Assessment Of Adherence Of The SSEC System To Skin

The adhesion of each SSEC was evaluated immediately prior to removal at each 24-hour time point, or at early withdrawal. Adhesion was recorded using the following classification: System adhered to at least 90% of the application area with no edges unattached; System adhered between 75% and 89%; System was <75% adhered and not taped; System was secured with tape. The number of SSEC systems for all time points in each category is presented. Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Immediately prior to removal at each 24-hour time point, or at early withdrawal, for up to 3 consecutive days (up to 72 hours)

InterventionSSEC systems (Number)
≥90% of area with no edges unattached75% to 89%<75% adhered and not tapedSystem was secured with tapeNot assessed
SSEC Fentanyl976310

Assessment Of Participant's Ability To Use The SSEC

Investigator's assessment of participant's ability to use the SSEC system safely and effectively. The assessment consisted of a 4-level categorical evaluation (poor, fair, good, and excellent). Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Completed at the time of the participant's termination of study treatment (up to 72 hours after study drug administration)

Interventionparticipants (Number)
PoorFairGoodExcellentMissing
SSEC Fentanyl1210480

Change From Baseline To 1 Hour And 24 Hours In Skin Irritation Score After SSEC Removal

Skin irritation at the SSEC application site was to be assessed immediately prior to placement of the study system and at 1 and 24 hours after removal of each study system. The application site was to be scored using the following scale: 0=No evidence of irritation; 1=Minimal erythema, barely perceptible; 2=Definite erythema, readily visible, minimal edema, or minimal papular response; 3=Erythema and papules; 4=Definite edema; 5=Erythema, edema, and papules; 6=Vesicular eruption; 7=Strong reaction spreading beyond the application site. (NCT02395653)
Timeframe: Baseline, 1 hour and 24 hours after SSEC removal.

Interventionunits on a scale (Mean)
System 1, Hour 1System 1, Hour 24System 2, Hour 1System 2, Hour 24System 3, Hour 1System 3, Hour 24
SSEC Fentanyl1.11.81.01.61.00.8

Number Of Participants To Experience Clinically Relevant Respiratory Depression (CRRD)

Respiratory function and occurrence of CRRD was defined as simultaneous occurrence of bradypnoea (respiratory rate <10 breaths per minute for participants 9-15 years of age and sustained for 1 minute, or <8 breaths per minute for participants 16-17 years of age), with excessive sedation (that is, the participant is not easily aroused). (NCT02395653)
Timeframe: From the time of application of the first system through 7 days following end of study drug administration.

Interventionparticipants (Number)
BradypnoeaExcessive SedationSimultaneous Bradypnoea and Excessive Sedation
SSEC Fentanyl000

Reviews

1 review available for fentanyl and Fever

ArticleYear
The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:5

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Fentanyl; Fever; Humans; Iontophore

2007

Trials

1 trial available for fentanyl and Fever

ArticleYear
Opioids inhibit febrile responses in humans, whereas epidural analgesia does not: an explanation for hyperthermia during epidural analgesia.
    Anesthesiology, 2001, Volume: 94, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Body Temperature; Cytokines; Fentanyl; Fever; Humans

2001

Other Studies

14 other studies available for fentanyl and Fever

ArticleYear
Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study.
    Anesthesia and analgesia, 2022, 12-01, Volume: 135, Issue:6

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Bupivacaine; Female; Fentanyl; Feve

2022
Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report.
    Medicine, 2020, Oct-02, Volume: 99, Issue:40

    Topics: Analgesics, Opioid; Autonomic Nervous System Diseases; Basal Ganglia; Brain Ischemia; Diffusion Tens

2020
Disseminated gonorrhea with laryngeal involvement in a 25-year-old man.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2021, 05-03, Volume: 193, Issue:18

    Topics: Administration, Intravenous; Adult; Anti-Bacterial Agents; Ceftriaxone; Exanthema; Fentanyl; Fever;

2021
A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats.
    Archives of pharmacal research, 2013, Volume: 36, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Disease Models, Animal; Dose-Respon

2013
[Measurement of amount of fentanyl remaining in used patches: investigation of clinical factors affecting the remaining amounts in 4 patients].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2008, Volume: 128, Issue:6

    Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Body Mass Index; Dosage Forms; Female; Fentanyl

2008
[Perioperative anesthetic management of a patient with multiple sclerosis].
    Masui. The Japanese journal of anesthesiology, 2009, Volume: 58, Issue:6

    Topics: Adult; Anesthesia, Epidural; Fentanyl; Fever; Flurbiprofen; Humans; Infusions, Intravenous; Laparosc

2009
Doctors and nurses, still learning.
    Alberta RN, 2009,Winter, Volume: 65, Issue:9

    Topics: Analgesics, Opioid; Clinical Competence; Communication; Fentanyl; Fever; Humans; Medical Staff, Hosp

2009
Brown adipose tissue thermogenesis contributes to fentanyl-evoked hyperthermia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 288, Issue:3

    Topics: Adipose Tissue, Brown; Animals; Cardiovascular System; Dorsomedial Hypothalamic Nucleus; Fentanyl; F

2005
Postoperative hyperthermia, rhabdomyolysis, critical temperature, and death in a former premature infant after his ninth general anesthetic.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:4

    Topics: Analgesics, Opioid; Anesthesia, General; Fatal Outcome; Fentanyl; Fever; Humans; Infant; Infant, New

2007
Unusual presentations of scorpion envenomation.
    Human & experimental toxicology, 2008, Volume: 27, Issue:1

    Topics: Adult; Analgesics, Opioid; Animals; Antivenins; Blood Cell Count; Blood Chemical Analysis; Echocardi

2008
Anesthetic management of whole-body hyperthermia for the treatment of cancer.
    Anesthesiology, 1980, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Aged; Anesthetics; Body Temperature; Body Temperature Regulation; Chemical and Dr

1980
Nonmalignant hyperthermia on induction of anesthesia in a pediatric patient undergoing bidirectional Glenn procedure.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:5

    Topics: Adjuvants, Anesthesia; Anastomosis, Surgical; Anesthesia, General; Anesthetics, Intravenous; Body Te

1998
Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000, Volume: 64, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animal Welfare; Animals; A

2000
[Extra-operative anesthesiological importance of the drugs used in neuroleptoanalgesia].
    Acta anaesthesiologica, 1965, Volume: 16

    Topics: Anesthesia; Anesthesia, Obstetrical; Benperidol; Fentanyl; Fever; Humans; Movement Disorders; Neurol

1965