fentanyl and Cough
fentanyl has been researched along with Cough in 96 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effects of intravenous (IV) fentanyl on cough reflex and quality of endotracheal intubation (ETI) in cats." | 9.69 | Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023) |
| "The study aimed to determine the efficacy of lidocaine at different low doses to reduce fentanyl-induced cough (FIC)." | 9.51 | Low-dose lidocaine attenuates fentanyl-induced cough: A double-blind randomized controlled trial. ( Jinawong, S; Munjupong, S; Phuvachoterojanaphokin, N; Watanaboonyongcharoen, G, 2022) |
| "Intravenous bolus injection of fentanyl has been frequently reported to be associated with cough reflex during patient anesthesia." | 9.41 | Comparison of lidocaine, huffing maneuver and combination of both in prevention fentanyl induced cough before induction of anesthesia: a double-blind, prospective, randomized placebo-controlled study. ( Bagheri Baravati, F; Dehghanpisheh, L; Eghbal, M; Vatankhah, P, 2021) |
| "Fentanyl-induced cough (FIC) usually occurs after the intravenous administration of fentanyl during general anaesthesia induction." | 9.34 | Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl-induced cough during induction of general anaesthesia. ( Cao, X; Dai, B, 2020) |
| "To compare the effects of intravenous (IV) lidocaine and fentanyl on the cough reflex and autonomic response during endotracheal intubation in dogs." | 9.34 | Comparison between intravenous lidocaine and fentanyl on cough reflex and sympathetic response during endotracheal intubation in dogs. ( Bravo, VR; Corletto, F; Palomba, N; Vettorato, E; Willis, R, 2020) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 9.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| "Fentanyl-induced cough (FIC) is unwanted in the patients requiring stable induction of general anesthesia." | 9.22 | Butorphanol suppresses fentanyl-induced cough during general anesthesia induction: A randomized, double-blinded, placebo-controlled clinical trial. ( Cheng, XY; Li, HB; Lun, XQ; Zhang, ZJ, 2016) |
| "This study was designed to investigate whether a priming dose of ketamine-dexmedetomidine can effectively suppress fentanyl-induced coughing (FIC)." | 9.19 | A priming dose of intravenous ketamine-dexmedetomidine suppresses fentanyl-induced coughing: a double-blind, randomized, controlled study. ( Hadi, SM; Ouyang, W; Saleh, AJ; Zhang, L, 2014) |
| "Fentanyl-induced cough is not an uncommon phenomenon during the induction of general anesthesia." | 9.16 | Effects of different priming doses of fentanyl on fentanyl-induced cough: a double-blind, randomized, controlled study. ( Gu, C; Li, F; Tang, Q; Wu, H; Zhou, M, 2012) |
| "The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable." | 9.16 | Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study. ( Dai, RP; He, L; Xu, JM, 2012) |
| "An intravenous bolus of fentanyl often induces a cough reflex." | 9.16 | Priming dose of intravenous rocuronium suppresses fentanyl-induced coughing. ( Horng, HC; Liaw, WJ; Lin, BF; Lin, SL; Wang, HJ; Wang, TC; Wong, CS, 2012) |
| "The incidence of fentanyl-induced cough (FIC) occurs frequently during induction of general anesthesia, and methods to prevent it are needed." | 9.16 | Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. ( Dong, C; Lu, Y; Xu, R; Yu, J; Zhu, H, 2012) |
| "Although fentanyl suppresses tracheal tube-induced cough during anesthetic recovery, it has not been proven if its antitussive effect is dose dependent and complication free." | 9.15 | Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia. ( Choi, EM; Jeong, JJ; Lee, JR; Moon, BE; Na, S; Yoo, YC, 2011) |
| "Fentanyl is commonly used during anaesthesia and can cause fentanyl-induced cough (FIC)." | 9.15 | Effects of a priming dose of fentanyl during anaesthesia on the incidence and severity of fentanyl-induced cough in current, former and non-smokers. ( Cho, HJ; Im, KS; Jung, HJ; Kim, JB; Kim, JW; Lee, JM, 2011) |
| "To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia." | 9.15 | Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial. ( Cui, Z; Han, XP; Sun, ZT; Yang, CY; Zhang, J, 2011) |
| "To determine if fentanyl-induced cough was dose-dependent in children and whether it could affect tracheal intubation." | 9.14 | The frequency of fentanyl-induced cough in children and its effects on tracheal intubation. ( Han, JI; Kim, CH; Lee, GY; Lee, H, 2010) |
| "To explore the effect of intravenous injection rate and site of fentanyl on the incidence and onset time of fentanyl-induced cough." | 9.14 | [Intravenous injection rate and site of fentanyl affect the incidence and onset time of fentanyl-induced cough]. ( Chen, WT; Chen, YM; Gu, MN; Liang, SW, 2009) |
| "IV fentanyl en bolus can provoke cough reflex." | 9.14 | [Incidence and onset time of fentanyl-induced cough depends on the dose of IV fentanyl]. ( Fukuda, K; Handa, M; Hayashida, M; Ichinohe, T; Iida, K; Kaneko, Y; Kasahara, M; Koukita, Y; Saita, N; Urabe, A, 2009) |
| "Fentanyl-induced cough is not an uncommon condition during the induction of general anesthesia." | 9.14 | Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: a preliminary randomized controlled study. ( Qian, Y; Tang, Q; Wang, Z; Yang, J; Zhang, Q, 2010) |
| "To observe the effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing." | 9.14 | [Effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing]. ( Liu, B; Wang, L; Yao, JH; Zhou, DC; Zhu, JG; Zhu, JJ, 2010) |
| "We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 microg) on the incidence of cough caused by a larger bolus of intravenous fentanyl." | 9.14 | The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing. ( Chen, CW; Hsieh, SW; Hung, KC; Lin, VC; Weng, HC, 2010) |
| " fentanyl bolus is associated with coughing in 28-65% of patients." | 9.14 | A huffing manoeuvre, immediately before induction of anaesthesia, prevents fentanyl-induced coughing: a prospective, randomized, and controlled study. ( Ambesh, SP; Gupta, D; Singh, N; Singh, PK; Singh, U, 2010) |
| "The aim of the study was to investigate whether the incidence of cough after intravenous fentanyl depends on the speed of injection." | 9.13 | Fentanyl-induced cough does not depend on injection speed: a randomized study. ( Hopf, HB; Schäpermeier, U, 2008) |
| "To evaluate the effect of low-dose ketamine on fentanyl-induced cough." | 9.12 | Premedication with intravenous low-dose ketamine suppresses fentanyl-induced cough. ( Huh, BK; J Sheen, M; Lee, MS; Lin, SL; Wong, CS; Wu, CT; Yeh, CC, 2007) |
| "Patients in the clonidine group showed a significantly lower incidence of cough than those in the control group (17." | 9.12 | Pre-medication with intravenous clonidine suppresses fentanyl-induced cough. ( Cherng, CH; Horng, HC; Hsiao, KN; Huh, BK; Kuo, CP; Wong, CS; Wu, CT, 2007) |
| "Fentanyl is regularly used in clinical anesthesia practice but fentanyl-induced cough (FIC) will sometimes bother anesthesiologists." | 9.12 | Intravenous dexamethasone pretreatment reduces fentanyl-induced cough. ( Chen, FC; Cherng, CH; Horng, HC; Lee, MS; Lin, JA; Wong, CS; Yeh, CC, 2007) |
| "We compared the incidence and severity of cough following a bolus of sufentanil with that following fentanyl in 510 patients, randomly allocated to receive sufentanil 0." | 9.12 | Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double-blind study. ( Agarwal, A; Gautam, S; Gupta, D; Nath, SS; Singh, U, 2007) |
| "IV lidocaine is effective in suppressing the cough reflex of tracheal intubation, extubation, bronchography, bronchoscopy, and laryngoscopy." | 9.11 | Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study. ( Agarwal, A; Lakra, A; Pandey, CK; Ranjan, R; Raza, M; Singh, PK; Singh, RB; Singh, U, 2004) |
| "To evaluate the minimal dose of lidocaine required for suppression of fentanyl-induced cough." | 9.11 | Intravenous lidocaine 0.5 mg.kg-1 effectively suppresses fentanyl-induced cough. ( Agarwal, A; Kumar, M; Lakra, A; Navkar, DV; Pandey, CK; Ranjan, R; Raza, M; Singh, PK; Singh, RB; Singh, U; Singhal, V, 2005) |
| "We designed this study to evaluate the effect of injection time and smoking on fentanyl-induced cough." | 9.11 | Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough. ( Lee, MS; Lin, JA; Lin, SL; Wong, CS; Wu, CT; Yeh, CC, 2005) |
| " Following iv fentanyl (2 micro g x kg(-1)) the incidence of cough was recorded and graded as mild (1-2), moderate (3-5) and severe (> 5) depending on the number of coughs observed." | 9.10 | Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl. ( Agarwal, A; Ambesh, S; Azim, A; Bose, N; Dhiraj, S; Sahu, D; Singh, U, 2003) |
| "To study the suppressive effect of inhalation of a selective beta 2-adrenergic bronchodilator terbutaline, and the effect of an intravenous anticholinergic, atropine, on fentanyl-induced coughing." | 9.08 | Terbutaline inhalation suppresses fentanyl-induced coughing. ( Chu, YC; Hsing, CH; Lui, PW, 1996) |
| "To evaluate whether different doses of intravenous lidocaine are effective at preventing fentanyl-induced cough (FIC), we searched PubMed, Scopus, Cochrane Library, EMBASE and Web of Science, according to predefined criteria, for all articles published until June 2017." | 8.98 | Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis. ( Gao, X; Guo, J; Huang, W; Li, S; Liu, X; Tan, W; Wang, Z, 2018) |
| "Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction." | 8.90 | Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis. ( Chae, YJ; Kim, JE; Kim, JY; Lee, YJ; Min, SK; Moon, BK, 2014) |
| " Sub-group analysis indicated a significant reduction in the incidence of both fentanyl-induced cough (FIC) and remifentanil-induced cough (RIC), but it appeared that lidocaine only alleviated the severity of FIC." | 8.90 | The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials. ( Guo, R; Sun, L, 2014) |
| "Many reports have demonstrated that intravenous administration of a bolus of fentanyl at induction of anesthesia can cause coughing with varying degrees." | 8.90 | Fentanyl-induced cough--pathophysiology and prevention. ( El Baissari, MC; Siddik-Sayyid, SM; Taha, SK, 2014) |
| "BACKGROUND Fentanyl-induced cough (FIC) during general anesthesia induction and postoperative nausea and vomiting are common complications, yet the risk factors for FIC remain controversial." | 8.02 | Risk Factors for Fentanyl-Induced Cough Following General Anesthesia in Adults: A Retrospective Study from a Single Center in China. ( Chen, LH; Li, ST; Wang, H; Wang, HJ; Wang, Y; Xing, YA; Zhao, X, 2021) |
| "Postoperative nausea and vomiting (PONV) and fentanyl-induced cough (FIC) are two common anaesthesia-related events, which seem to have common risk factors." | 7.81 | Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting. ( Chen, LK; Chen, SS; Chien, KL; Fan, SZ; Huang, CH; Leighton, BL; Li, CC; Yang, HJ, 2015) |
| "To determine how the probability of fentanyl-induced cough is affected by patient characteristics and/or anesthetic technique." | 7.73 | Identification of independent risk factors for fentanyl-induced cough. ( Dohi, S; Kasuya, Y; Murakami, T; Okumura, Y; Oshima, T, 2006) |
| "We designed a case-controlled matching study to investigate the correlation between fentanyl-induced coughing and airway hyperresponsiveness." | 7.71 | Fentanyl-induced coughing and airway hyperresponsiveness. ( Chiang, SC; Hsin, ST; Luk, HN; Tsou, CH; Wang, JH, 2002) |
| "Fentanyl is a strong µ-opioid analgesic which attenuates the stimulation of surgical invasion and tracheal intubation." | 6.84 | Swallowing action immediately before intravenous fentanyl at induction of anesthesia prevents fentanyl-induced coughing: a randomized controlled study. ( Fujimura, N; Sako, S; Tokunaga, S; Tsukamoto, M; Yokoyama, T; Yoshino, J, 2017) |
| "To assess the effects of intravenous (IV) fentanyl on cough reflex and quality of endotracheal intubation (ETI) in cats." | 5.69 | Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023) |
| " The time to extubation, respiratory complications, nausea, pain, and the number of patients receiving fentanyl were comparable between the groups." | 5.69 | The Impact of Head Elevation on Prevalence and Severity of Emergence Cough in Male Patients during Endotracheal Extubation. ( Kim, JE; Kim, JH; Lim, GM; Park, SJ; Park, SY, 2023) |
| " The purpose of this study is to investigate the efficacy of nebulized fentanyl citrate on dyspnea, cough, and throat pain in patients with COVID-19 and evaluate the safety with any potential adverse events." | 5.51 | Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial). ( Abujaber, AA; Al-Assaf, AA; Khatib, MY; Mohamed, AS; Nashwan, AJ; Shaikh, N; Tharayil, AGM; Wraidat, MAA, 2022) |
| "To compare the effects of intravenous (IV) lidocaine and fentanyl on the cough reflex and autonomic response during endotracheal intubation in dogs." | 5.34 | Comparison between intravenous lidocaine and fentanyl on cough reflex and sympathetic response during endotracheal intubation in dogs. ( Bravo, VR; Corletto, F; Palomba, N; Vettorato, E; Willis, R, 2020) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 5.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| "Fentanyl-induced cough (FIC) is unwanted in the patients requiring stable induction of general anesthesia." | 5.22 | Butorphanol suppresses fentanyl-induced cough during general anesthesia induction: A randomized, double-blinded, placebo-controlled clinical trial. ( Cheng, XY; Li, HB; Lun, XQ; Zhang, ZJ, 2016) |
| "Coughing was observed in six (12%) and ten (20%) in the fentanyl and control group, respectively (P = 0." | 5.20 | Does small-dose fentanyl improve perioperative outcomes in the ambulatory setting? A randomized, double-blind, placebo-controlled study. ( Elvir-Lazo, OL; Kariger, R; Khany, MM; Stern, A; Vuong, M; Wender, RH; White, PF; Yumul, R; Zaentz, AS, 2015) |
| "A dose of 1 mg/kg of tramadol administered intravenously 30 minutes before the expected extubation, compared with 1 μg/kg of fentanyl, decreased cough incidence, improved emergence quality, and provided stable hemodynamics." | 5.16 | Comparison between intraoperative fentanyl and tramadol to improve quality of emergence. ( Chan, SM; Cherng, CH; Hung, NK; Ju, DT; Lin, BF; Wu, CT; Yeh, CC, 2012) |
| "Although fentanyl suppresses tracheal tube-induced cough during anesthetic recovery, it has not been proven if its antitussive effect is dose dependent and complication free." | 5.15 | Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia. ( Choi, EM; Jeong, JJ; Lee, JR; Moon, BE; Na, S; Yoo, YC, 2011) |
| "We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 microg) on the incidence of cough caused by a larger bolus of intravenous fentanyl." | 5.14 | The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing. ( Chen, CW; Hsieh, SW; Hung, KC; Lin, VC; Weng, HC, 2010) |
| " with Steyn modification which includes five criteria; ease of laryngoscopy, degree of coughing, position of vocal cords, jaw relaxation, and limb movement and graded on a 4-point scale." | 5.12 | Comparative evaluation of different doses of propofol preceded by fentanyl on intubating conditions and pressor response during tracheal intubation without muscle relaxants. ( Gupta, A; Kale, S; Kaur, R; Malhotra, R, 2006) |
| "The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2." | 5.12 | Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children. ( Kim, C; Kim, H; Kim, S; Lee, J; Oh, Y; Park, H, 2006) |
| "The history of smoking and premedication did not influence the proportion of patients who had a cough response to fentanyl when administrated as first agent during induction in anesthesia." | 5.12 | The influence of premedication and smoking. ( Atsalakis, J; Dimitriou, V; Ioakimidou, A; Koursoumi, E; Saranteas, T; Spyrou, A; Stranomiti, J, 2006) |
| "We compared the incidence and severity of cough following a bolus of sufentanil with that following fentanyl in 510 patients, randomly allocated to receive sufentanil 0." | 5.12 | Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double-blind study. ( Agarwal, A; Gautam, S; Gupta, D; Nath, SS; Singh, U, 2007) |
| "To evaluate the minimal dose of lidocaine required for suppression of fentanyl-induced cough." | 5.11 | Intravenous lidocaine 0.5 mg.kg-1 effectively suppresses fentanyl-induced cough. ( Agarwal, A; Kumar, M; Lakra, A; Navkar, DV; Pandey, CK; Ranjan, R; Raza, M; Singh, PK; Singh, RB; Singh, U; Singhal, V, 2005) |
| " Following iv fentanyl (2 micro g x kg(-1)) the incidence of cough was recorded and graded as mild (1-2), moderate (3-5) and severe (> 5) depending on the number of coughs observed." | 5.10 | Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl. ( Agarwal, A; Ambesh, S; Azim, A; Bose, N; Dhiraj, S; Sahu, D; Singh, U, 2003) |
| " Patients with only mild pain when coughing during thoracic epidural infusion of about 10 ml per hour of bupivacaine 1 mg x ml(-1), fentanyl 2 microg x ml(-1), and adrenaline 2 microg x ml(-1) were included." | 5.09 | Epidural fentanyl markedly improves thoracic epidural analgesia in a low-dose infusion of bupivacaine, adrenaline and fentanyl. A randomized, double-blind crossover study with and without fentanyl. ( Breivik, H; Niemi, G, 2001) |
| "The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl." | 5.07 | Tussive effect of a fentanyl bolus. ( Jong, W; Lee, TL; Phua, WT; Teh, BT; Tweed, WA, 1991) |
| " Sub-group analysis indicated a significant reduction in the incidence of both fentanyl-induced cough (FIC) and remifentanil-induced cough (RIC), but it appeared that lidocaine only alleviated the severity of FIC." | 4.90 | The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials. ( Guo, R; Sun, L, 2014) |
| "Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction." | 4.90 | Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis. ( Chae, YJ; Kim, JE; Kim, JY; Lee, YJ; Min, SK; Moon, BK, 2014) |
| "BACKGROUND Fentanyl-induced cough (FIC) during general anesthesia induction and postoperative nausea and vomiting are common complications, yet the risk factors for FIC remain controversial." | 4.02 | Risk Factors for Fentanyl-Induced Cough Following General Anesthesia in Adults: A Retrospective Study from a Single Center in China. ( Chen, LH; Li, ST; Wang, H; Wang, HJ; Wang, Y; Xing, YA; Zhao, X, 2021) |
| "Postoperative nausea and vomiting (PONV) and fentanyl-induced cough (FIC) are two common anaesthesia-related events, which seem to have common risk factors." | 3.81 | Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting. ( Chen, LK; Chen, SS; Chien, KL; Fan, SZ; Huang, CH; Leighton, BL; Li, CC; Yang, HJ, 2015) |
| "To determine how the probability of fentanyl-induced cough is affected by patient characteristics and/or anesthetic technique." | 3.73 | Identification of independent risk factors for fentanyl-induced cough. ( Dohi, S; Kasuya, Y; Murakami, T; Okumura, Y; Oshima, T, 2006) |
| "We designed a case-controlled matching study to investigate the correlation between fentanyl-induced coughing and airway hyperresponsiveness." | 3.71 | Fentanyl-induced coughing and airway hyperresponsiveness. ( Chiang, SC; Hsin, ST; Luk, HN; Tsou, CH; Wang, JH, 2002) |
| "The incidence of myoclonus was significantly lower in the nalmefene group (8." | 3.30 | Low-dose nalmefene pretreatment reduces etomidate-induced myoclonus: A randomized, double-blind controlled trial. ( Cao, H; Dai, F; Liu, Y; Lu, H; Shan, G; Yin, D, 2023) |
| "The incidence of gagging (P = 0." | 2.68 | Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion. ( Bapat, P; Jago, RH; Joshi, RN; Young, E, 1996) |
| "Therefore, postoperative pain control after OLT should be carefully titrated according to the severity of the liver disease." | 1.38 | The relationship between postoperative intravenous patient-controlled fentanyl analgesic requirements and severity of liver disease. ( Gwak, MS; Jang, CH; Kim, GS; Ko, JS; Lee, SK; Shin, YH, 2012) |
Research
Studies (96)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.08) | 18.7374 |
| 1990's | 13 (13.54) | 18.2507 |
| 2000's | 31 (32.29) | 29.6817 |
| 2010's | 39 (40.63) | 24.3611 |
| 2020's | 11 (11.46) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sirohiya, P | 1 |
| Kumar, V | 1 |
| Mittal, S | 1 |
| Gupta, N | 1 |
| Garg, R | 1 |
| Bharati, SJ | 1 |
| Mishra, S | 1 |
| Hadda, V | 1 |
| Mohan, A | 1 |
| Sagiraju, HKR | 1 |
| Bhatnagar, S | 1 |
| Madan, K | 1 |
| Shaikh, N | 1 |
| Khatib, MY | 1 |
| Wraidat, MAA | 1 |
| Mohamed, AS | 1 |
| Al-Assaf, AA | 1 |
| Tharayil, AGM | 1 |
| Abujaber, AA | 1 |
| Nashwan, AJ | 1 |
| Phuvachoterojanaphokin, N | 1 |
| Watanaboonyongcharoen, G | 1 |
| Jinawong, S | 1 |
| Munjupong, S | 1 |
| Martín Bellido, V | 1 |
| Martínez I Ferré, B | 1 |
| McDonald, H | 1 |
| Vettorato, E | 2 |
| Shan, G | 1 |
| Lu, H | 1 |
| Dai, F | 1 |
| Liu, Y | 1 |
| Yin, D | 1 |
| Cao, H | 1 |
| Lim, GM | 1 |
| Park, SJ | 1 |
| Park, SY | 1 |
| Kim, JH | 1 |
| Kim, JE | 2 |
| Shim, JS | 1 |
| Song, WJ | 1 |
| Morice, AH | 1 |
| Bravo, VR | 1 |
| Palomba, N | 1 |
| Corletto, F | 1 |
| Willis, R | 1 |
| Dai, B | 1 |
| Cao, X | 1 |
| Dehghanpisheh, L | 1 |
| Eghbal, M | 1 |
| Bagheri Baravati, F | 1 |
| Vatankhah, P | 1 |
| Zhao, X | 1 |
| Wang, H | 1 |
| Wang, HJ | 2 |
| Wang, Y | 2 |
| Xing, YA | 1 |
| Li, ST | 1 |
| Chen, LH | 1 |
| Ho, CN | 1 |
| Hung, KC | 4 |
| Yin, N | 1 |
| Xia, J | 1 |
| Cao, YZ | 1 |
| Lu, X | 1 |
| Yuan, J | 1 |
| Xie, J | 1 |
| Tsukamoto, M | 2 |
| Yokoyama, T | 2 |
| Naldan, ME | 1 |
| Arslan, Z | 1 |
| Ay, A | 1 |
| Yayık, AM | 1 |
| Tan, W | 1 |
| Li, S | 1 |
| Liu, X | 1 |
| Gao, X | 1 |
| Huang, W | 1 |
| Guo, J | 1 |
| Wang, Z | 2 |
| Min, SK | 1 |
| Chae, YJ | 1 |
| Lee, YJ | 1 |
| Moon, BK | 1 |
| Kim, JY | 1 |
| De Oliveira, GS | 1 |
| Fitzgerald, PC | 1 |
| Ahmad, S | 1 |
| Marcus, RJ | 1 |
| McCarthy, RJ | 1 |
| Sun, L | 2 |
| Guo, R | 1 |
| El Baissari, MC | 1 |
| Taha, SK | 1 |
| Siddik-Sayyid, SM | 1 |
| White, PF | 1 |
| Elvir-Lazo, OL | 1 |
| Zaentz, AS | 1 |
| Kariger, R | 1 |
| Yumul, R | 1 |
| Khany, MM | 1 |
| Stern, A | 1 |
| Vuong, M | 1 |
| Wender, RH | 1 |
| Saleh, AJ | 1 |
| Zhang, L | 1 |
| Hadi, SM | 1 |
| Ouyang, W | 1 |
| Murphy, GS | 1 |
| Szokol, JW | 1 |
| Avram, MJ | 1 |
| Greenberg, SB | 1 |
| Marymont, JH | 1 |
| Shear, T | 1 |
| Parikh, KN | 1 |
| Patel, SS | 1 |
| Gupta, DK | 1 |
| Li, CC | 1 |
| Chen, SS | 1 |
| Huang, CH | 1 |
| Chien, KL | 1 |
| Yang, HJ | 1 |
| Fan, SZ | 1 |
| Leighton, BL | 1 |
| Chen, LK | 1 |
| Kelly, HE | 1 |
| Shaw, GM | 1 |
| Brett, CN | 1 |
| Greenwood, FM | 1 |
| Huckabee, ML | 1 |
| Allen, G | 1 |
| Cheng, XY | 1 |
| Lun, XQ | 1 |
| Li, HB | 1 |
| Zhang, ZJ | 1 |
| Peringathara, B | 1 |
| Robinson, S | 1 |
| Sako, S | 1 |
| Tokunaga, S | 1 |
| Yoshino, J | 1 |
| Fujimura, N | 1 |
| Schäpermeier, U | 1 |
| Hopf, HB | 1 |
| Chen, YM | 1 |
| Chen, WT | 1 |
| Liang, SW | 1 |
| Gu, MN | 1 |
| Iida, K | 2 |
| Handa, M | 1 |
| Fukuda, K | 2 |
| Saita, N | 1 |
| Kasahara, M | 1 |
| Koukita, Y | 2 |
| Urabe, A | 1 |
| Hayashida, M | 1 |
| Ichinohe, T | 1 |
| Kaneko, Y | 1 |
| Uvelin, A | 1 |
| Rakic, G | 1 |
| Tang, Q | 2 |
| Qian, Y | 1 |
| Zhang, Q | 1 |
| Yang, J | 1 |
| Chen, CW | 1 |
| Lin, VC | 1 |
| Weng, HC | 1 |
| Hsieh, SW | 1 |
| Ambesh, SP | 1 |
| Singh, N | 1 |
| Gupta, D | 2 |
| Singh, PK | 3 |
| Singh, U | 5 |
| Han, JI | 1 |
| Lee, H | 1 |
| Kim, CH | 1 |
| Lee, GY | 1 |
| Schäfer, M | 1 |
| Keilig, S | 1 |
| Brack, A | 1 |
| Kranke, P | 1 |
| Mizutani, K | 1 |
| Elcock, DH | 1 |
| Inomata, S | 1 |
| Maeda, T | 1 |
| Shimizu, T | 1 |
| Satsumae, T | 1 |
| Tanaka, M | 1 |
| Wang, L | 1 |
| Yao, JH | 1 |
| Zhu, JJ | 1 |
| Liu, B | 2 |
| Zhu, JG | 1 |
| Zhou, DC | 1 |
| Sun, ZT | 1 |
| Yang, CY | 1 |
| Cui, Z | 1 |
| Zhang, J | 1 |
| Han, XP | 1 |
| Makkar, JK | 1 |
| Ghai, B | 1 |
| Bhardwaj, N | 1 |
| Wig, J | 1 |
| Lin, BF | 2 |
| Ju, DT | 1 |
| Cherng, CH | 3 |
| Hung, NK | 1 |
| Yeh, CC | 4 |
| Chan, SM | 1 |
| Wu, CT | 4 |
| Yoo, YC | 1 |
| Na, S | 1 |
| Jeong, JJ | 1 |
| Choi, EM | 1 |
| Moon, BE | 1 |
| Lee, JR | 1 |
| Sun, Q | 1 |
| Zhou, W | 1 |
| Wu, B | 1 |
| Ji, MH | 1 |
| Peng, YG | 1 |
| Jung, HJ | 1 |
| Kim, JB | 1 |
| Im, KS | 1 |
| Cho, HJ | 1 |
| Kim, JW | 1 |
| Lee, JM | 1 |
| He, L | 1 |
| Xu, JM | 1 |
| Dai, RP | 1 |
| Yu, J | 1 |
| Lu, Y | 1 |
| Dong, C | 1 |
| Zhu, H | 1 |
| Xu, R | 1 |
| Ko, JS | 1 |
| Shin, YH | 1 |
| Gwak, MS | 1 |
| Jang, CH | 1 |
| Kim, GS | 1 |
| Lee, SK | 1 |
| Gu, C | 1 |
| Zhou, M | 1 |
| Wu, H | 1 |
| Li, F | 1 |
| Horng, HC | 3 |
| Wang, TC | 1 |
| Lin, SL | 3 |
| Liaw, WJ | 1 |
| Wong, CS | 5 |
| Tsou, CH | 1 |
| Luk, HN | 1 |
| Chiang, SC | 1 |
| Hsin, ST | 1 |
| Wang, JH | 1 |
| Agarwal, A | 4 |
| Azim, A | 1 |
| Ambesh, S | 1 |
| Bose, N | 1 |
| Dhiraj, S | 1 |
| Sahu, D | 1 |
| Pandey, CK | 2 |
| Raza, M | 2 |
| Ranjan, R | 2 |
| Lakra, A | 2 |
| Singh, RB | 2 |
| Singhal, V | 1 |
| Kumar, M | 1 |
| Navkar, DV | 1 |
| Schlimp, CJ | 1 |
| Wiedermann, FJ | 1 |
| Ortiz-Gómez, JR | 1 |
| Carrascosa, F | 1 |
| Pérez-Cajaraville, JJ | 1 |
| Percaz-Bados, JA | 1 |
| Añez, C | 1 |
| Lin, JA | 2 |
| Lee, MS | 3 |
| Gupta, A | 1 |
| Kaur, R | 1 |
| Malhotra, R | 1 |
| Kale, S | 1 |
| Oshima, T | 1 |
| Kasuya, Y | 1 |
| Okumura, Y | 1 |
| Murakami, T | 1 |
| Dohi, S | 1 |
| Lee, J | 1 |
| Oh, Y | 1 |
| Kim, C | 1 |
| Kim, S | 1 |
| Park, H | 1 |
| Kim, H | 1 |
| Dimitriou, V | 1 |
| Spyrou, A | 1 |
| Ioakimidou, A | 1 |
| Stranomiti, J | 1 |
| Koursoumi, E | 1 |
| Atsalakis, J | 1 |
| Saranteas, T | 1 |
| Huh, BK | 2 |
| J Sheen, M | 1 |
| Hsiao, KN | 1 |
| Kuo, CP | 1 |
| Hohlrieder, M | 1 |
| Tiefenthaler, W | 1 |
| Klaus, H | 1 |
| Gabl, M | 1 |
| Kavakebi, P | 1 |
| Keller, C | 1 |
| Benzer, A | 1 |
| Yu, H | 1 |
| Yang, XY | 1 |
| Zhang, X | 1 |
| Li, Q | 1 |
| Zhu, T | 1 |
| Chen, FC | 1 |
| Gautam, S | 1 |
| Nath, SS | 1 |
| Ishiyama, T | 1 |
| Iijima, T | 1 |
| Sugawara, T | 1 |
| Shibuya, K | 1 |
| Sato, H | 1 |
| Terada, Y | 1 |
| Ichikawa, M | 1 |
| Sessler, DI | 1 |
| Matsukawa, T | 1 |
| Koh, KF | 1 |
| Chen, FG | 1 |
| Schwender, D | 1 |
| Faber-Züllig, E | 1 |
| Klasing, S | 1 |
| Pöppel, E | 1 |
| Peter, K | 1 |
| Bapat, P | 1 |
| Joshi, RN | 1 |
| Young, E | 1 |
| Jago, RH | 1 |
| Lui, PW | 1 |
| Hsing, CH | 1 |
| Chu, YC | 1 |
| Sanderson, PM | 1 |
| Inagaki, Y | 1 |
| Shindo, H | 1 |
| Mashimo, T | 1 |
| Yoshiya, I | 1 |
| Sjöström, S | 1 |
| Bläss, J | 1 |
| Niemi, G | 3 |
| Breivik, H | 3 |
| Carrero Cardenal, EJ | 1 |
| Valero Castell, R | 1 |
| Roux Carmona, C | 1 |
| Lapena Bayo, C | 1 |
| Ortells Ribé, J | 1 |
| Artigas Rubio, X | 1 |
| Beebe, DS | 1 |
| Tran, P | 1 |
| Bragg, M | 1 |
| Stillman, A | 1 |
| Truwitt, C | 1 |
| Belani, KG | 1 |
| Olympio, MA | 1 |
| Youngblood, BL | 1 |
| James, RL | 1 |
| Kong, CF | 1 |
| Chew, ST | 1 |
| Ip-Yam, PC | 1 |
| Tweed, WA | 2 |
| Dakin, D | 1 |
| D'Olimpio, J | 1 |
| Tammisto, T | 1 |
| Mattila, MJ | 1 |
| Gin, T | 1 |
| Chui, PT | 1 |
| Phua, WT | 1 |
| Teh, BT | 1 |
| Jong, W | 1 |
| Lee, TL | 1 |
| Böhrer, H | 1 |
| Fleischer, F | 1 |
| Werning, P | 1 |
| Ananthanarayan, C | 1 |
| d' Hollander, AA | 1 |
| Monteny, E | 1 |
| Dewachter, B | 1 |
| Sanders, M | 1 |
| Dubois-Primo, J | 1 |
Clinical Trials (14)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy[NCT04712162] | 60 participants (Actual) | Interventional | 2019-11-19 | Completed | |||
| The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia: A Prospective Randomized Double-blinded Control Study[NCT03006250] | Phase 4 | 220 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Effect of Fentanyl on the Incidence of Coughing and Recovery After Propofol-Desflurane Anesthesia With an LMA for Airway Management[NCT01368809] | Phase 4 | 100 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation[NCT05075265] | 30 participants (Anticipated) | Observational | 2021-10-02 | Not yet recruiting | |||
| Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy - a Randomized Controlled Trial[NCT05445856] | Phase 4 | 130 participants (Anticipated) | Interventional | 2022-11-28 | Recruiting | ||
| Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Double-blind, Randomised Controlled Trial[NCT03908060] | 126 participants (Actual) | Interventional | 2019-05-06 | Active, not recruiting | |||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875] | 26 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Drug Shortage) | |||
| Effect of Head Position on Minimum Alveolar Concentration of Endotracheal Intubation（MACEI）of Sevoflurane in Children With Obstructive Airway[NCT03522402] | 38 participants (Anticipated) | Interventional | 2018-01-01 | Enrolling by invitation | |||
| Effect of Single Dose of Tramadol on Extubation Response and Quality of Emergence(Cough and Nausea Vomiting) Following Supratentorial Intracranial Surgery[NCT02964416] | Phase 4 | 80 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial[NCT04991493] | Phase 4 | 168 participants (Anticipated) | Interventional | 2021-09-10 | Recruiting | ||
| Can Propofol Reduce Respiratory Adverse Events During Extubation in Children With Tonsillectomy? A Prospective Randomized Controlled Study[NCT05769842] | 240 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | |||
| Effect of Two Plasma Concentrations of Remifentanil Through Target Controlled Anesthesia on Frequency and Intensity of Coughing During Extubation: Randomized Controlled Clinical Trial[NCT02711904] | Phase 4 | 110 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Incidence of Coughing
during the perioperative period (insertion of an LMA device, maintenance of anesthesia, and emergence from general anesthesia) for ambulatory surgery procedures. (NCT01368809)
Timeframe: one day
| Intervention | participants (Number) |
|---|---|
| Fentanyl | 10 |
| Saline Solution | 6 |
Incidence of Nausea and Vomiting
Postoperative nausea and vomiting using a Verbal Rating Scale (0-10) at PACU (post-anesthesia care unit. (NCT01368809)
Timeframe: 1 day
| Intervention | participants (Number) |
|---|---|
| Fentanyl | 2 |
| Saline Solution | 4 |
Postoperative Pain
"Postoperative pain measured using a Verbal Rating Scale (VRS) at post-anesthesia care unit (PACU), (90 minutes after arriving).~Postoperative pain VRS scores: 0 = none pain to 10 = intolerable pain." (NCT01368809)
Timeframe: one day
| Intervention | Scores on a scale (Mean) |
|---|---|
| Fentanyl | 1.5 |
| Saline Solution | 1.5 |
Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.
The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours
| Intervention | mg postop morphine equivelant 24hr (Mean) |
|---|---|
| Control - Fentanyl | 0.55 |
| Treatment - Methadone | 0.48 |
Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting
Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours
| Intervention | events (Mean) | |||
|---|---|---|---|---|
| Ondansetron Doses | Emesis Episodes | Hypoventilation Episodes | Arrhythmias | |
| Control - Fentanyl | 3.81 | 2.72 | 0 | 0 |
| Treatment - Methadone | 3.43 | 2.08 | 0 | 0 |
Measure the Quality of Emergence From General Anaesthesia by Measuring the Frequency of Laryngospasm and Bronchospasm.
If there is any episode of bronchospasm or laryngospasm, it will be noted if it occured during emergence and for 6 hours post operatively. Absence of it will be considered as smooth emergence (NCT02964416)
Timeframe: at the time of extubation till 6 hours postoperatively
| Intervention | Number of Patients (Number) |
|---|---|
| Tramadol | 0 |
| Placebo | 0 |
Effect of Tramadol on Quality of Emergence Measured by Extubation Response Through Mointoring Requirement of Analgesia
Requirement of analgesia will be recorded at recovery room, 2, 4 and 6 hours postoperatively. If there is any need of analgesic, it will be noted and will be considered as one of the determinants of poor quality of emergence. (NCT02964416)
Timeframe: At Recovery room, 2, 4 and 6 hours postoperatively
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Recovery Room | 2h | 4h | 6h | |
| Placebo | 3 | 23 | 4 | 7 |
| Tramadol | 5 | 15 | 3 | 6 |
Effect of Tramadol on Quality of Emergence Measured by Extubation Response Through Monitoring Convulsions
Convulsions will be recorded at Recovery Room, 2, 4 and 6 hours postoperatively.If there is any episode of convulsion, it will be noted. Absence of it will be considered as smooth emergence. (NCT02964416)
Timeframe: at Recovery Room, 2, 4 and 6 hours postoperatively
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Recovery Room | 2h | 4h | 6h | |
| Placebo | 0 | 0 | 0 | 0 |
| Tramadol | 0 | 0 | 1 | 0 |
Effect of Tramadol on Quality of Emergence Measured by Extubation Response Through Monitoring GCS
"Post operative Glasgow Coma Scale (GCS) will be recorded at Recovery Room, 2, 4 and 6 hours postoperatively. If there is any deterioration in GCS less than 8/15, Patients will be intubated.~GCS categories <8 Low GCS 9-12 Intermediate GCS 13-15 Full GCS" (NCT02964416)
Timeframe: at Recovery Room, 2, 4 and 6 hours postoperatively
| Intervention | Number of Patients (Number) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Recovery Room : <8 | Recovery Room : 9-12 | Recovery Room : 13-15 | 2h : <8 | 2h : 9-12 | 2h : 13-15 | 4h : <8 | 4h : 9-12 | 4h : 13-15 | 6h : <8 | 6h : 9-12 | 6h : 13-15 | |
| Placebo | 0 | 0 | 41 | 0 | 1 | 40 | 1 | 0 | 40 | 1 | 0 | 40 |
| Tramadol | 0 | 1 | 38 | 0 | 1 | 38 | 0 | 0 | 39 | 0 | 0 | 39 |
Effect of Tramadol on Quality of Emergence Measured by Extubation Response Through Monitoring PONV
Post operative nausea vomiting will be recorded at RR, 2, 4 and 6 hours postoperatively. If there is any episode of PONV it will be noted. Absence of it will be considered as smooth emergence (NCT02964416)
Timeframe: at Recovery Room , 2, 4 and 6 hours postoperatively
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Recovery Room | 2h | 4h | 6h | |
| Placebo | 0 | 3 | 1 | 1 |
| Tramadol | 0 | 3 | 0 | 0 |
Haemodynamic Parameters at the Time of Emergence and Postextubation
Diastolic blood pressure will be recorded at 1 minute before giving the reversal (glycopyrolate and neostigmine) and then 1,2,5,10,20,30 minutes ,1,2,4 and 6 hours after extubation. If values of blood pressure rise more than 20% from baseline values injection Metoprolol 1mg (beta blocker) bolus will be used and titrated according to response. The study will end at 6 hours post extubation. (NCT02964416)
Timeframe: Diastolic BP from the time of extubation till 6 hours post operatively
| Intervention | mm Hg (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Base line | 1min Before Extubation | 1min After Extubation | 2 min | 5min | 10min | 20min | 30min | 1h | 2h | 4h | 6h | |
| Placebo | 77.83 | 78.65 | 85.78 | 82.41 | 78.59 | 78.32 | 76.73 | 76.93 | 75.33 | 75.89 | 78.00 | 74.89 |
| Tramadol | 75.92 | 77.30 | 83.97 | 79.19 | 78.68 | 77.37 | 78.19 | 77.14 | 76.39 | 75.71 | 74.85 | 75.26 |
Haemodynamic Parameters at the Time of Emergence and Postextubation
Heart rate will be recorded at 1 minute before giving the reversal (glycopyrolate and neostigmine) and then 1,2,5,10,20,30 minutes ,1,2,4 and 6 hours after extubation. If haemodynamic values of heart rate rise more than 20% from baseline values injection Metoprolol 1mg (beta blocker) bolus will be used and titrated according to response. The study will end at 6 hours post extubation. (NCT02964416)
Timeframe: HR from the time of extubation till 6 hours post operatively
| Intervention | bpm (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 1min Before Extubation | 1min After Extubation | 2 min | 5min | 10min | 20min | 30min | 1h | 2h | 4h | 6h | |
| Placebo | 79.37 | 91.41 | 98.54 | 93.50 | 90.00 | 86.70 | 83.38 | 84.10 | 82.46 | 81.97 | 81.23 | 78.20 |
| Tramadol | 82.26 | 89.30 | 93.61 | 89.61 | 86.27 | 86.26 | 82.44 | 81.92 | 79.53 | 80.03 | 78.94 | 79.65 |
Haemodynamic Parameters at the Time of Emergence and Postextubation
Systolic blood pressure will be recorded at 1 minute before giving the reversal (glycopyrolate and neostigmine) and then 1,2,5,10,20,30 minutes ,1,2,4 and 6 hours after extubation. If values of blood pressure rise more than 20% from baseline values injection Metoprolol 1mg (beta blocker) bolus will be used and titrated according to response. The study will end at 6 hours post extubation. (NCT02964416)
Timeframe: Systolic BP from the time of extubation till 6 hours post operatively
| Intervention | mm Hg (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 1min Before Extubation | 1min After Extubation | 2 min | 5min | 10min | 20min | 30min | 1h | 2h | 4h | 6h | |
| Placebo | 132.34 | 134.29 | 143.70 | 139.77 | 133.37 | 131.59 | 133.15 | 132.10 | 129.80 | 125.74 | 125.81 | 122.61 |
| Tramadol | 128.55 | 132.63 | 141.81 | 134.89 | 130.05 | 126.95 | 127.86 | 127.19 | 128.11 | 127.76 | 127.35 | 122.97 |
Measure the Quality of Emergence From General Anaesthesia by Measuring the Frequency of Episodes of Denaturation
"If there is any episodes of denaturation (Oxygen saturation <92%), it will be noted it it is occurring during emergence.~Absence of it will be considered as smooth emergence" (NCT02964416)
Timeframe: at the time of extubation
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| at resumption of spontaneous breathing | at the time of obeying of verbal commands | at the time of cuff deflation | at the time of extubation | 2 min after extubation | |
| Placebo | 0 | 0 | 0 | 0 | 0 |
| Tramadol | 0 | 0 | 0 | 0 | 0 |
Measure the Quality of Emergence From General Anaesthesia by Measuring the Frequency of Cough on Cough Scale.
"Cough will be described on following scale 5 = No coughing or straining, 4 = Very smooth minimal coughing, 3 = Moderate coughing, 2 = Marked coughing or straining,~1 = Poor extubation~Cough will be recorded on the above mentioned scale by resident/consultant at following time intervals of emergence~At resumption of spontaneous breathing,~Ability to respond to verbal commands~At cuff deflation~At extubation~2 minutes after extubation. It will be noted if it occurs during emergence at the above mentioned time intervals. Absence of it will be considered as smooth emergence." (NCT02964416)
Timeframe: Cough at the time of emergence
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| At resumption of spontaneous breathing72201515 | At resumption of spontaneous breathing72201516 | Ability to respond to verbal commands72201516 | Ability to respond to verbal commands72201515 | At cuff deflation72201516 | At cuff deflation72201515 | At extubation72201516 | At extubation72201515 | 2 minutes after extubation72201515 | 2 minutes after extubation72201516 | |||||||||||||||||||||||||||||||||||||||||
| Poor extubation | Marked coughing or straining | Moderate coughing | Very smooth minimal coughing | No coughing or straining | ||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 33 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 36 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 34 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 37 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 33 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 32 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Placebo | 32 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tramadol | 36 | |||||||||||||||||||||||||||||||||||||||||||||||||
Reviews
6 reviews available for fentanyl and Cough
| Article | Year |
|---|---|
Drug-Induced Cough.
Topics: Analgesics, Opioid; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Chr | 2020 |
Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis.
Topics: Administration, Intravenous; Adult; Child; Cough; Fentanyl; Humans; Lidocaine; Treatment Outcome | 2018 |
Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis.
Topics: Administration, Intravenous; Adrenergic Agonists; Adult; Anesthetics, Intravenous; Anesthetics, Loca | 2014 |
The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Anesthetics, Local; Cough; Female; Fentanyl; | 2014 |
Fentanyl-induced cough--pathophysiology and prevention.
Topics: Anesthetics, Intravenous; Cough; Fentanyl; Humans | 2014 |
Contemporary drug therapy in palliative care: new directions.
Topics: Adrenal Cortex Hormones; Analgesics; Anorexia; Antiemetics; Antitussive Agents; Cachexia; Cough; Dru | 2001 |
Trials
63 trials available for fentanyl and Cough
| Article | Year |
|---|---|
Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT).
Topics: Analgesics, Opioid; Conscious Sedation; Cough; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Seda | 2022 |
Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial).
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Analgesics, Opioid; Clinical Trials, Phase III | 2022 |
Low-dose lidocaine attenuates fentanyl-induced cough: A double-blind randomized controlled trial.
Topics: Anesthesia, General; Anesthetics, Local; Cough; Double-Blind Method; Fentanyl; Humans; Lidocaine; Pr | 2022 |
Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats.
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Apnea; Cat Diseases; Cats; Cough; Dexmedetom | 2023 |
Low-dose nalmefene pretreatment reduces etomidate-induced myoclonus: A randomized, double-blind controlled trial.
Topics: Anesthesia, General; Cough; Drug-Related Side Effects and Adverse Reactions; Etomidate; Fentanyl; Hu | 2023 |
The Impact of Head Elevation on Prevalence and Severity of Emergence Cough in Male Patients during Endotracheal Extubation.
Topics: Airway Extubation; Cough; Fentanyl; Humans; Intubation, Intratracheal; Male; Pain; Prevalence | 2023 |
Comparison between intravenous lidocaine and fentanyl on cough reflex and sympathetic response during endotracheal intubation in dogs.
Topics: Anesthetics, Intravenous; Animals; Autonomic Nervous System; Blood Pressure; Cough; Dog Diseases; Do | 2020 |
Comparing the different oxycodone doses of prevent oxycodone for prevention of preventing fentanyl-induced cough during induction of general anaesthesia.
Topics: Adult; Aged; Anesthesia, General; Cough; Fentanyl; Humans; Middle Aged; Oxycodone; Pharmaceutical Pr | 2020 |
Comparison of lidocaine, huffing maneuver and combination of both in prevention fentanyl induced cough before induction of anesthesia: a double-blind, prospective, randomized placebo-controlled study.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Cough; Double-Blind Method | 2021 |
Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Antitussive Agents; Bridged Bicyclo Compounds, Heterocy | 2017 |
Comparison of Lidocaine and Atropine on Fentanyl-Induced Cough: A Randomized Controlled Study.
Topics: Anesthesia; Anesthetics, Local; Atropine; Child; Child, Preschool; Cough; Female; Fentanyl; Humans; | 2019 |
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, | 2013 |
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, | 2013 |
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, | 2013 |
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, | 2013 |
Does small-dose fentanyl improve perioperative outcomes in the ambulatory setting? A randomized, double-blind, placebo-controlled study.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Cough; Double-Blind Method; Female; Fenta | 2015 |
A priming dose of intravenous ketamine-dexmedetomidine suppresses fentanyl-induced coughing: a double-blind, randomized, controlled study.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Cough; Dexmedetomidine; Double-Blind Method; Female; F | 2014 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Butorphanol suppresses fentanyl-induced cough during general anesthesia induction: A randomized, double-blinded, placebo-controlled clinical trial.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Antitussive Agents; Butorphanol; Cough; Double | 2016 |
Swallowing action immediately before intravenous fentanyl at induction of anesthesia prevents fentanyl-induced coughing: a randomized controlled study.
Topics: Administration, Intravenous; Adult; Analgesics, Opioid; Cough; Deglutition; Elective Surgical Proced | 2017 |
Fentanyl-induced cough does not depend on injection speed: a randomized study.
Topics: Cough; Female; Fentanyl; Humans; Injections, Intravenous; Male; Middle Aged; Time Factors | 2008 |
[Intravenous injection rate and site of fentanyl affect the incidence and onset time of fentanyl-induced cough].
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Cough; Female; Fentanyl; Humans; Injections, Intrave | 2009 |
[Incidence and onset time of fentanyl-induced cough depends on the dose of IV fentanyl].
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics, Intravenous; Cough; Dose-Response Relationship, | 2009 |
Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: a preliminary randomized controlled study.
Topics: Adjuvants, Anesthesia; Adult; Anesthetics, Intravenous; Cough; Dose-Response Relationship, Drug; Fem | 2010 |
The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Blood Pressure; Cough; Dose-Response Relationship | 2010 |
A huffing manoeuvre, immediately before induction of anaesthesia, prevents fentanyl-induced coughing: a prospective, randomized, and controlled study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Cough; Exhalation; Female; Fentanyl; Humans; Injections | 2010 |
The frequency of fentanyl-induced cough in children and its effects on tracheal intubation.
Topics: Adolescent; Child; Child, Preschool; Cough; Dose-Response Relationship, Drug; Double-Blind Method; F | 2010 |
Effects of fentanyl infusion on tracheal intubation and emergence agitation in preschool children anaesthetized with sevoflurane.
Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Inhalation; | 2010 |
[Effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Cough; Female; Fentanyl; Humans; Male; Middle Aged; Yo | 2010 |
Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial.
Topics: Anesthesia, General; Anesthetics, Intravenous; Bridged Bicyclo Compounds, Heterocyclic; Cough; Doubl | 2011 |
Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pr | 2012 |
Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pr | 2012 |
Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pr | 2012 |
Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pr | 2012 |
Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia.
Topics: Adult; Airway Extubation; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; | 2011 |
Effects of a priming dose of fentanyl during anaesthesia on the incidence and severity of fentanyl-induced cough in current, former and non-smokers.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Cough; Dose-Response Relatio | 2011 |
Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Adult; Cough; Dexmedetomidine; Double-B | 2012 |
Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Cough; Dexmedetomidine; Drug Combinations; Female | 2012 |
Effects of different priming doses of fentanyl on fentanyl-induced cough: a double-blind, randomized, controlled study.
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Cough; Dose-Response Relationship, Drug; | 2012 |
Priming dose of intravenous rocuronium suppresses fentanyl-induced coughing.
Topics: Adult; Aged; Analgesics, Opioid; Androstanols; Cough; Female; Fentanyl; Humans; Injections, Intraven | 2012 |
Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl.
Topics: Adolescent; Adult; Albuterol; Beclomethasone; Cough; Cromolyn Sodium; Female; Fentanyl; Histamine Re | 2003 |
Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study.
Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Cough; Double-Blind Method; Fema | 2004 |
Intravenous lidocaine 0.5 mg.kg-1 effectively suppresses fentanyl-induced cough.
Topics: Adolescent; Adult; Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Cough; Double-Blind Met | 2005 |
Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium.
Topics: Adjuvants, Anesthesia; Adult; Aged; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Atr | 2005 |
Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Anesthetics, Intravenous; Cough | 2005 |
Comparative evaluation of different doses of propofol preceded by fentanyl on intubating conditions and pressor response during tracheal intubation without muscle relaxants.
Topics: Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Cough; Doubl | 2006 |
Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children.
Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Apnea; Blood Pressure; Child; Chil | 2006 |
The influence of premedication and smoking.
Topics: Anesthetics, Intravenous; Anti-Anxiety Agents; Cough; Elective Surgical Procedures; Fentanyl; Humans | 2006 |
Premedication with intravenous low-dose ketamine suppresses fentanyl-induced cough.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Cough; Double-Blind | 2007 |
Pre-medication with intravenous clonidine suppresses fentanyl-induced cough.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Blood Pre | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2007 |
The effect of dilution and prolonged injection time on fentanyl-induced coughing.
Topics: Adult; Anesthetics, Intravenous; Cough; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; | 2007 |
Intravenous dexamethasone pretreatment reduces fentanyl-induced cough.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cough; Dexamethasone; Female; | 2007 |
Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double-blind study.
Topics: Adult; Analgesics, Opioid; Cough; Double-Blind Method; Female; Fentanyl; Humans; Intraoperative Comp | 2007 |
Rapid tracheal intubation with atracurium: the timing principle.
Topics: Adult; Anesthesia, Intravenous; Atracurium; Blood Pressure; Cough; Female; Fentanyl; Flushing; Heart | 1994 |
Motor signs of wakefulness during general anaesthesia with propofol, isoflurane and flunitrazepam/fentanyl and midlatency auditory evoked potentials.
Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Cough; Evoked Potentials, Auditory; Female; Fentan | 1994 |
Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Cough; Drug Costs; Elective Surgical Procedures | 1996 |
Terbutaline inhalation suppresses fentanyl-induced coughing.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonist | 1996 |
The effects of epidural fentanyl on hemodynamic responses during emergence from isoflurane anesthesia and tracheal extubation: a comparison with intravenous fentanyl.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Inhalati | 1997 |
Postoperative analgesia with epidural bupivacaine and low-dose fentanyl--a comparison of two concentrations.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Buprenorphine; Colon | 1998 |
Adrenaline markedly improves thoracic epidural analgesia produced by a low-dose infusion of bupivacaine, fentanyl and adrenaline after major surgery. A randomised, double-blind, cross-over study with and without adrenaline.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; | 1998 |
[Our negative experience with meperidine for the prevention of coughing during cataract surgery].
Topics: Antitussive Agents; Cataract Extraction; Cough; Double-Blind Method; Fentanyl; Humans; Intraocular P | 1999 |
Emergence from anesthesia in the prone versus supine position in patients undergoing lumbar surgery.
Topics: Androstanols; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Anestheti | 2000 |
Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthetics, Inhalation; Cough; Desflurane; Female; F | 2000 |
Epidural fentanyl markedly improves thoracic epidural analgesia in a low-dose infusion of bupivacaine, adrenaline and fentanyl. A randomized, double-blind crossover study with and without fentanyl.
Topics: Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Cough; Cross-Over Studies | 2001 |
Epinephrine markedly improves thoracic epidural analgesia produced by a small-dose infusion of ropivacaine, fentanyl, and epinephrine after major thoracic or abdominal surgery: a randomized, double-blinded crossover study with and without epinephrine.
Topics: Adjuvants, Anesthesia; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioi | 2002 |
Antitussive respiratory depressant effects of dextromoramide, fentanyl, morphine, pentazocine, and pethidine during the N2O-O2 anaesthesia in man.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Antitussive Agents; Atropi | 1977 |
Tussive effect of a fentanyl bolus.
Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Atropine; Blood Pressure; Cough; Double-Blind | 1991 |
Tussive effect of a fentanyl bolus administered through a central venous catheter.
Topics: Catheterization, Central Venous; Catheterization, Peripheral; Cough; Fentanyl; Humans; Male; Middle | 1990 |
Other Studies
27 other studies available for fentanyl and Cough
| Article | Year |
|---|---|
Risk Factors for Fentanyl-Induced Cough Following General Anesthesia in Adults: A Retrospective Study from a Single Center in China.
Topics: Adjuvants, Anesthesia; Administration, Intravenous; Adult; Anesthesia, General; Anesthetics, Intrave | 2021 |
Effect of swallowing maneuver on fentanyl-induced coughing.
Topics: Analgesics, Opioid; Anesthesia; Cough; Deglutition; Fentanyl; Humans | 2017 |
Effect of swallowing maneuver on fentanyl-induced coughing.
Topics: Analgesics, Opioid; Cough; Deglutition; Fentanyl; Humans | 2017 |
Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting.
Topics: Adult; Anesthetics, Intravenous; Causality; Cohort Studies; Comorbidity; Cough; Female; Fentanyl; Hu | 2015 |
The effect of titrated fentanyl on suppressed cough reflex in healthy adult volunteers.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Citric Acid; Cough; Dose-Response Relationship, Drug; F | 2016 |
Evidence appraisal of Li CC, Chen SS, Huang CH, et al. Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting. Br J Anaesth. 2015;115(3):444-448.
Topics: Anesthetics, Intravenous; Cough; Female; Fentanyl; Humans; Postoperative Nausea and Vomiting | 2016 |
Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting.
Topics: Anesthetics, Intravenous; Cough; Fentanyl; Humans; Postoperative Nausea and Vomiting; Risk Factors; | 2016 |
Incidence of fentanyl-induced cough and injection speed.
Topics: Analgesics, Opioid; Catheterization, Peripheral; Cough; Dose-Response Relationship, Drug; Fentanyl; | 2009 |
The possible mechanism of clonidine to suppress fentanyl-induced coughing.
Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Clonidine; Cough; Fentanyl; Humans; Muscle Rigi | 2009 |
Guidelines for prevention of fentanyl-induced cough.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Asthma; Cough; Fentanyl; Humans | 2009 |
[Opioid induced cough: Do we know its pathophysiology and can it be eliminated?].
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Local; Clonidine; Cough; Fentanyl; Human | 2010 |
[Fentanyl-induced cough].
Topics: Anesthetics, Intravenous; Cough; Dose-Response Relationship, Drug; Fentanyl; Humans; Injections, Int | 2010 |
[Cough reflex after intravenous injection of fentanyl].
Topics: Anesthetics, Intravenous; Cough; Dose-Response Relationship, Drug; Fentanyl; Humans; Injections, Int | 2010 |
Fentanyl-induced cough.
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Cough; Fentanyl; Humans; Propofol | 2010 |
Minimum alveolar concentration of desflurane with fentanyl for laryngeal mask airway removal in anesthetized children.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Cou | 2012 |
Dezocine: a novel drug to prevent fentanyl-induced cough during general anesthesia induction?
Topics: Anesthetics, Intravenous; Bridged Bicyclo Compounds, Heterocyclic; Cough; Female; Fentanyl; Humans; | 2012 |
The relationship between postoperative intravenous patient-controlled fentanyl analgesic requirements and severity of liver disease.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Chi-Square Distribution; Cough; Female; Fentanyl; | 2012 |
Fentanyl-induced coughing and airway hyperresponsiveness.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Angiotensin-Converting Enzyme Inhibitors; Bronchial Hyp | 2002 |
Does fentanyl-induced cough justify pre-treatment with iv lidocaine 2 mg.kg-1.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Bronchodilator Agents; Cough; Ephedrine; Fentanyl; Hum | 2005 |
Identification of independent risk factors for fentanyl-induced cough.
Topics: Adult; Age Factors; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Angiotensin- | 2006 |
The use of patient-controlled epidural fentanyl in elderly patients.
Topics: Abdomen; Adult; Age Factors; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Body Weight; C | 2007 |
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch | 1997 |
Trained nurses can provide safe and effective sedation for MRI in pediatric patients.
Topics: Administration, Rectal; Adolescent; Age Factors; Anesthesia, General; Anesthesiology; Anesthetics, I | 2000 |
Explosive coughing after bolus fentanyl injection.
Topics: Adolescent; Analgesics, Opioid; Cough; Down Syndrome; Fentanyl; Humans; Injections, Intravenous; Mal | 2001 |
Coughing after fentanyl.
Topics: Anesthesia, Intravenous; Cough; Fentanyl; Humans; Pseudotumor Cerebri | 1992 |
Tussive effect of fentanyl.
Topics: Anesthesia, Intravenous; Cough; Fentanyl; Humans | 1990 |
Intubation under topical supra-glottic analgesia in unpremedicated and non-fasting patients: amnesic effects of sub-hypnotic doses of diazepam and Innovar.
Topics: Adolescent; Adult; Aged; Amnesia; Analgesia; Cough; Diazepam; Droperidol; Drug Combinations; Female; | 1974 |