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doxapram and Cough

doxapram has been researched along with Cough in 3 studies

Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"In a double-blind study patients given a single dose of doxapram 1-5-2-0 mg/kg combined with morphine postoperatively had a significantly lower incidence of reflex postoperative cough and expectoration of purulent sputum than patients given morphine alone."5.04Role of doxapram in reducing pulmonary complications after major surgery. ( Dundee, JW; Gawley, TH; Gupta, PK; Jones, CJ, 1976)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Drummond, GB1
Park, GR1
Gawley, TH1
Dundee, JW1
Gupta, PK1
Jones, CJ1
Jansen, JE1
Sorensen, AI1
Naesh, O1
Erichsen, CJ1
Pedersen, A1

Trials

3 trials available for doxapram and Cough

ArticleYear
Doxapram and postoperative chest complications.
    Anaesthesia, 1983, Volume: 38, Issue:1

    Topics: Abdomen; Clinical Trials as Topic; Cough; Double-Blind Method; Doxapram; Female; Humans; Lung Diseas

1983
Role of doxapram in reducing pulmonary complications after major surgery.
    British medical journal, 1976, Jan-17, Volume: 1, Issue:6002

    Topics: Adolescent; Adult; Clinical Trials as Topic; Cough; Doxapram; Female; Humans; Lung Diseases; Male; M

1976
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients.
    Lancet (London, England), 1990, Apr-21, Volume: 335, Issue:8695

    Topics: Abdomen; Adult; Aged; Blood Gas Analysis; Cough; Double-Blind Method; Doxapram; Drug Administration

1990