doxapram has been researched along with Cough in 3 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Excerpt | Relevance | Reference |
---|---|---|
"In a double-blind study patients given a single dose of doxapram 1-5-2-0 mg/kg combined with morphine postoperatively had a significantly lower incidence of reflex postoperative cough and expectoration of purulent sputum than patients given morphine alone." | 5.04 | Role of doxapram in reducing pulmonary complications after major surgery. ( Dundee, JW; Gawley, TH; Gupta, PK; Jones, CJ, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (66.67) | 18.7374 |
1990's | 1 (33.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Drummond, GB | 1 |
Park, GR | 1 |
Gawley, TH | 1 |
Dundee, JW | 1 |
Gupta, PK | 1 |
Jones, CJ | 1 |
Jansen, JE | 1 |
Sorensen, AI | 1 |
Naesh, O | 1 |
Erichsen, CJ | 1 |
Pedersen, A | 1 |
3 trials available for doxapram and Cough
Article | Year |
---|---|
Doxapram and postoperative chest complications.
Topics: Abdomen; Clinical Trials as Topic; Cough; Double-Blind Method; Doxapram; Female; Humans; Lung Diseas | 1983 |
Role of doxapram in reducing pulmonary complications after major surgery.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cough; Doxapram; Female; Humans; Lung Diseases; Male; M | 1976 |
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients.
Topics: Abdomen; Adult; Aged; Blood Gas Analysis; Cough; Double-Blind Method; Doxapram; Drug Administration | 1990 |