clonidine and Sepsis
clonidine has been researched along with Sepsis in 6 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure." | 7.81 | Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015) |
| " Presently, the most robust clinical evidence involves the use of the cardioselective β-blocker esmolol in patients with septic shock with persistent tachycardia secondary to catecholamine use." | 4.98 | Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock. ( Bissell, BD; Ferreira, JA, 2018) |
| "Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure." | 3.81 | Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis. ( Bellomo, R; Booth, LC; Evans, RG; Kosaka, J; Lankadeva, YR; May, CN; Quintin, L, 2015) |
| "With early trauma, beta-adrenergic responsiveness and receptor number were significantly decreased." | 1.27 | Adrenergic control of adipocyte lipolysis in trauma and sepsis. ( Askanazi, J; Forse, RA; Hirsch, J; Kinney, JM; Leibel, R, 1987) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lankadeva, YR | 2 |
| Shehabi, Y | 1 |
| Deane, AM | 1 |
| Plummer, MP | 1 |
| Bellomo, R | 2 |
| May, CN | 2 |
| Booth, LC | 1 |
| Kosaka, J | 1 |
| Evans, RG | 1 |
| Quintin, L | 2 |
| Gradwohl-Matis, I | 1 |
| Dünser, MW | 1 |
| Geloën, A | 1 |
| Ferreira, JA | 1 |
| Bissell, BD | 1 |
| Forse, RA | 1 |
| Leibel, R | 1 |
| Askanazi, J | 1 |
| Hirsch, J | 1 |
| Kinney, JM | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals[NCT04100486] | 48 participants (Anticipated) | Observational | 2019-08-29 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for clonidine and Sepsis
| Article | Year |
|---|---|
Emerging benefits and drawbacks of α
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Clonidine; Critical Illness; Dexmed | 2021 |
Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Animals; Catecholamine | 2018 |
Other Studies
4 other studies available for clonidine and Sepsis
| Article | Year |
|---|---|
Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2015 |
Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2015 |
Reverse Physiology, i.e., Cellular Versus Integrative Versus Comparative Physiology? α-2 Agonists and Septic Shock.
Topics: Adrenergic alpha-2 Receptor Agonists; Angiotensin II; Animals; Blood Pressure; Clonidine; Female; Hy | 2016 |
Adrenergic control of adipocyte lipolysis in trauma and sepsis.
Topics: Adipose Tissue; Adult; Aged; Clonidine; Energy Metabolism; Female; Humans; Isoproterenol; Lipolysis; | 1987 |