clonidine and Autism
clonidine has been researched along with Autism in 14 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine." | 9.07 | Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 6.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| "The clonidine treatment showed a significant difference from placebo treatment on three subscales of the Ritvo-Freeman Real Life Rating Scale (i." | 6.67 | A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. ( Fankhauser, MP; German, ML; Karumanchi, SD; Karumanchi, VC; Yates, A, 1992) |
| "8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine." | 5.07 | Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992) |
| "Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD." | 2.73 | Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008) |
| "Seizures are reported to occur more frequently among children with diagnoses of autism and pervasive developmental disorder (PDD), and some reports indicate a frequency as high as 30%." | 2.71 | EEG sedation for children with autism. ( Castello, FV; Mehta, UC; Patel, I, 2004) |
| "The clonidine treatment showed a significant difference from placebo treatment on three subscales of the Ritvo-Freeman Real Life Rating Scale (i." | 2.67 | A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. ( Fankhauser, MP; German, ML; Karumanchi, SD; Karumanchi, VC; Yates, A, 1992) |
| "Children and adolescents diagnosed with autism and related pervasive developmental disorders (PDDs) often sustain irritability, including aggression, self-injurious behavior, and tantrums." | 2.44 | Pharmacotherapy of irritability in pervasive developmental disorders. ( McDougle, CJ; Stigler, KA, 2008) |
| "Clonidine was administered first (dose: 0." | 1.28 | Growth hormone response to L-dopa and clonidine in autistic children. ( Garfinkel, BD; Jensen, JB; Realmuto, GM; Reeve, E, 1990) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Stigler, KA | 1 |
| McDougle, CJ | 3 |
| Dowben, JS | 1 |
| Grant, JS | 1 |
| Keltner, NL | 1 |
| Posey, D | 1 |
| Niederhofer, H | 1 |
| Staffen, W | 1 |
| Mair, A | 1 |
| Mehta, UC | 1 |
| Patel, I | 1 |
| Castello, FV | 1 |
| Ming, X | 1 |
| Gordon, E | 1 |
| Kang, N | 1 |
| Wagner, GC | 1 |
| Koshes, RJ | 1 |
| Rock, NL | 1 |
| Campbell, M | 1 |
| Schopler, E | 1 |
| Cueva, JE | 1 |
| Hallin, A | 1 |
| McCracken, JT | 1 |
| Martin, W | 1 |
| Storch, DD | 1 |
| Jaselskis, CA | 1 |
| Cook, EH | 1 |
| Fletcher, KE | 1 |
| Leventhal, BL | 1 |
| Fankhauser, MP | 1 |
| Karumanchi, VC | 1 |
| German, ML | 1 |
| Yates, A | 1 |
| Karumanchi, SD | 1 |
| Realmuto, GM | 1 |
| Jensen, JB | 1 |
| Reeve, E | 1 |
| Garfinkel, BD | 1 |
Reviews
2 reviews available for clonidine and Autism
| Article | Year |
|---|---|
Pharmacotherapy of irritability in pervasive developmental disorders.
Topics: Adolescent; Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Child Devel | 2008 |
Treatment of autistic disorder.
Topics: Antipsychotic Agents; Autistic Disorder; Behavior Therapy; Clomipramine; Clonidine; Fenfluramine; Hu | 1996 |
Trials
5 trials available for clonidine and Autism
| Article | Year |
|---|---|
Lofexidine in hyperactive and impulsive children with autistic disorder.
Topics: Autistic Disorder; Child; Child, Preschool; Clonidine; Double-Blind Method; Female; Humans; Hyperkin | 2002 |
EEG sedation for children with autism.
Topics: Autistic Disorder; Child Development Disorders, Pervasive; Clonidine; Electroencephalography; Humans | 2004 |
Use of clonidine in children with autism spectrum disorders.
Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Attention Deficit Disorder with Hyperactivity; At | 2008 |
Clonidine treatment of hyperactive and impulsive children with autistic disorder.
Topics: Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Autistic Disorde | 1992 |
A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism.
Topics: Administration, Cutaneous; Adolescent; Adult; Arousal; Attitude to Health; Autistic Disorder; Child; | 1992 |
Other Studies
7 other studies available for clonidine and Autism
| Article | Year |
|---|---|
Clonidine: diverse use in pharmacologic management.
Topics: Adolescent; Adult; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Autistic Disord | 2011 |
Genetics of childhood disorders: XLIV. autism, part 3: psychopharmacology of autism.
Topics: Adrenergic alpha-Agonists; Autistic Disorder; Central Nervous System Stimulants; Clonidine; Humans; | 2002 |
Methylphenidate an effective treatment for ADHD?
Topics: Adrenergic alpha-Agonists; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Auti | 2004 |
Use of clonidine for behavioral control in an adult patient with autism.
Topics: Administration, Cutaneous; Adult; Aggression; Autistic Disorder; Clonidine; Female; Humans; Treatmen | 1994 |
Clonidine side effect.
Topics: Adrenergic alpha-Agonists; Aggression; Autistic Disorder; Child; Clonidine; Depression; Humans; Male | 1997 |
Medication-induced hypomania in Asperger's disorder.
Topics: Affective Symptoms; Attention Deficit and Disruptive Behavior Disorders; Autistic Disorder; Child; C | 1999 |
Growth hormone response to L-dopa and clonidine in autistic children.
Topics: Adolescent; Autistic Disorder; Child; Clonidine; Growth Hormone; Humans; Levodopa; Male; Pilot Proje | 1990 |