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clonidine and Autism

clonidine has been researched along with Autism in 14 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine."9.07Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992)
"Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD."6.73Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008)
"The clonidine treatment showed a significant difference from placebo treatment on three subscales of the Ritvo-Freeman Real Life Rating Scale (i."6.67A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. ( Fankhauser, MP; German, ML; Karumanchi, SD; Karumanchi, VC; Yates, A, 1992)
"8 years) with autistic disorder, diagnosed by DSM-III-R criteria, completed a placebo-controlled, double-blind crossover trial of clonidine."5.07Clonidine treatment of hyperactive and impulsive children with autistic disorder. ( Cook, EH; Fletcher, KE; Jaselskis, CA; Leventhal, BL, 1992)
"Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD."2.73Use of clonidine in children with autism spectrum disorders. ( Gordon, E; Kang, N; Ming, X; Wagner, GC, 2008)
"Seizures are reported to occur more frequently among children with diagnoses of autism and pervasive developmental disorder (PDD), and some reports indicate a frequency as high as 30%."2.71EEG sedation for children with autism. ( Castello, FV; Mehta, UC; Patel, I, 2004)
"The clonidine treatment showed a significant difference from placebo treatment on three subscales of the Ritvo-Freeman Real Life Rating Scale (i."2.67A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism. ( Fankhauser, MP; German, ML; Karumanchi, SD; Karumanchi, VC; Yates, A, 1992)
"Children and adolescents diagnosed with autism and related pervasive developmental disorders (PDDs) often sustain irritability, including aggression, self-injurious behavior, and tantrums."2.44Pharmacotherapy of irritability in pervasive developmental disorders. ( McDougle, CJ; Stigler, KA, 2008)
"Clonidine was administered first (dose: 0."1.28Growth hormone response to L-dopa and clonidine in autistic children. ( Garfinkel, BD; Jensen, JB; Realmuto, GM; Reeve, E, 1990)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (50.00)18.2507
2000's6 (42.86)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stigler, KA1
McDougle, CJ3
Dowben, JS1
Grant, JS1
Keltner, NL1
Posey, D1
Niederhofer, H1
Staffen, W1
Mair, A1
Mehta, UC1
Patel, I1
Castello, FV1
Ming, X1
Gordon, E1
Kang, N1
Wagner, GC1
Koshes, RJ1
Rock, NL1
Campbell, M1
Schopler, E1
Cueva, JE1
Hallin, A1
McCracken, JT1
Martin, W1
Storch, DD1
Jaselskis, CA1
Cook, EH1
Fletcher, KE1
Leventhal, BL1
Fankhauser, MP1
Karumanchi, VC1
German, ML1
Yates, A1
Karumanchi, SD1
Realmuto, GM1
Jensen, JB1
Reeve, E1
Garfinkel, BD1

Reviews

2 reviews available for clonidine and Autism

ArticleYear
Pharmacotherapy of irritability in pervasive developmental disorders.
    Child and adolescent psychiatric clinics of North America, 2008, Volume: 17, Issue:4

    Topics: Adolescent; Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Child Devel

2008
Treatment of autistic disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:2

    Topics: Antipsychotic Agents; Autistic Disorder; Behavior Therapy; Clomipramine; Clonidine; Fenfluramine; Hu

1996

Trials

5 trials available for clonidine and Autism

ArticleYear
Lofexidine in hyperactive and impulsive children with autistic disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:12

    Topics: Autistic Disorder; Child; Child, Preschool; Clonidine; Double-Blind Method; Female; Humans; Hyperkin

2002
EEG sedation for children with autism.
    Journal of developmental and behavioral pediatrics : JDBP, 2004, Volume: 25, Issue:2

    Topics: Autistic Disorder; Child Development Disorders, Pervasive; Clonidine; Electroencephalography; Humans

2004
Use of clonidine in children with autism spectrum disorders.
    Brain & development, 2008, Volume: 30, Issue:7

    Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Attention Deficit Disorder with Hyperactivity; At

2008
Clonidine treatment of hyperactive and impulsive children with autistic disorder.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:5

    Topics: Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Autistic Disorde

1992
A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Arousal; Attitude to Health; Autistic Disorder; Child;

1992

Other Studies

7 other studies available for clonidine and Autism

ArticleYear
Clonidine: diverse use in pharmacologic management.
    Perspectives in psychiatric care, 2011, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Autistic Disord

2011
Genetics of childhood disorders: XLIV. autism, part 3: psychopharmacology of autism.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:11

    Topics: Adrenergic alpha-Agonists; Autistic Disorder; Central Nervous System Stimulants; Clonidine; Humans;

2002
Methylphenidate an effective treatment for ADHD?
    Journal of autism and developmental disorders, 2004, Volume: 34, Issue:5

    Topics: Adrenergic alpha-Agonists; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Auti

2004
Use of clonidine for behavioral control in an adult patient with autism.
    The American journal of psychiatry, 1994, Volume: 151, Issue:11

    Topics: Administration, Cutaneous; Adult; Aggression; Autistic Disorder; Clonidine; Female; Humans; Treatmen

1994
Clonidine side effect.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Agonists; Aggression; Autistic Disorder; Child; Clonidine; Depression; Humans; Male

1997
Medication-induced hypomania in Asperger's disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:2

    Topics: Affective Symptoms; Attention Deficit and Disruptive Behavior Disorders; Autistic Disorder; Child; C

1999
Growth hormone response to L-dopa and clonidine in autistic children.
    Journal of autism and developmental disorders, 1990, Volume: 20, Issue:4

    Topics: Adolescent; Autistic Disorder; Child; Clonidine; Growth Hormone; Humans; Levodopa; Male; Pilot Proje

1990