cimetidine and Cancer of Colon
cimetidine has been researched along with Cancer of Colon in 27 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice." | 3.71 | Effect of cimetidine on intratumoral cytokine expression in an experimental tumor. ( Ichikawa, A; Takahashi, K; Tanaka, S, 2001) |
"The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma." | 3.67 | Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985) |
"Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals." | 1.32 | Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. ( Izumi, K; Okabe, S; Tomita, K, 2003) |
"Histamine has a trophic effect on at least two colorectal cancer cell lines in vivo and in vitro." | 1.29 | Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. ( Adams, WJ; Lawson, JA; Morris, DL, 1994) |
"Colon cancer was induced in 40 Sprague Dawley rats using a 10-week course of 1,2 dimethylhydrazine (DMH)." | 1.29 | The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine. ( Adams, WJ; Cook, TA; Lawson, JA; Morris, DL; Nicholson, SE, 1993) |
"Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells." | 1.29 | Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth. ( Adams, WJ; Lawson, JA; Morris, DL, 1996) |
" So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy." | 1.27 | Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983) |
"Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis." | 1.27 | Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat. ( Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B, 1984) |
"Four lines of human colorectal cancer were established and serially propagated as subcutaneous xenographs in immunosuppressed inbred CBA/Lac mice." | 1.26 | Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors. ( Barkla, DH; Tutton, PJ, 1981) |
Research
Studies (27)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (51.85) | 18.7374 |
1990's | 8 (29.63) | 18.2507 |
2000's | 5 (18.52) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Fujiwara, S | 1 |
Noguchi, T | 2 |
Suehiro, S | 1 |
Kikuchi, R | 1 |
Uchida, Y | 1 |
Tomita, K | 1 |
Izumi, K | 1 |
Okabe, S | 1 |
Hsu, TC | 1 |
Su, CF | 1 |
Leu, SC | 1 |
Huang, PC | 1 |
Wang, TE | 1 |
Chu, CH | 1 |
Lefranc, F | 1 |
Yeaton, P | 1 |
Brotchi, J | 1 |
Kiss, R | 1 |
Doldi, K | 1 |
Manger, B | 1 |
Koch, B | 1 |
Riemann, J | 1 |
Hermanek, P | 1 |
Kalden, JR | 1 |
Simon, GL | 1 |
Gorbach, SL | 1 |
Colin-Jones, DG | 1 |
Langman, MJ | 1 |
Lawson, DH | 1 |
Vessey, MP | 1 |
Caignard, A | 1 |
Martin, M | 1 |
Reisser, D | 1 |
Thomas, B | 1 |
Martin, F | 1 |
Nee, J | 1 |
O'Higgins, N | 1 |
Osborne, DH | 1 |
Purdy, S | 1 |
Barkla, DH | 3 |
Tutton, PJ | 4 |
Ewe, K | 1 |
Matsumoto, S | 1 |
Svendsen, LB | 1 |
Ross, C | 1 |
Knigge, U | 1 |
Frederiksen, HJ | 1 |
Graversen, P | 1 |
Kjaergård, J | 1 |
Luke, M | 1 |
Stimpel, H | 1 |
Sparsø, BH | 1 |
Adams, WJ | 3 |
Lawson, JA | 3 |
Morris, DL | 3 |
Nicholson, SE | 1 |
Cook, TA | 1 |
Sasson, AR | 1 |
Gamagami, R | 1 |
An, Z | 1 |
Wang, X | 1 |
Moossa, AR | 1 |
Hoffman, RM | 1 |
Takahashi, K | 1 |
Tanaka, S | 1 |
Ichikawa, A | 1 |
Steel, GG | 1 |
Weiss, RB | 1 |
Donehower, RC | 1 |
Wiernik, PH | 1 |
Ohnuma, T | 1 |
Gralla, RJ | 1 |
Trump, DL | 1 |
Baker, JR | 1 |
Van Echo, DA | 1 |
Von Hoff, DD | 1 |
Leyland-Jones, B | 1 |
Nakajima, I | 1 |
Chu, TM | 1 |
Shike, M | 1 |
Gillin, JS | 1 |
Kemeny, N | 1 |
Daly, JM | 1 |
Kurtz, RC | 1 |
Flodgren, P | 1 |
Sjögren, HO | 1 |
Jewell, LD | 1 |
Fields, AL | 1 |
Murray, CJ | 1 |
Thomson, AB | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090] | Phase 3 | 27 participants (Actual) | Interventional | 2020-02-14 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
2 reviews available for cimetidine and Cancer of Colon
Article | Year |
---|---|
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli | 2006 |
Intestinal flora in health and disease.
Topics: Adolescent; Adult; Aged; Bacteria, Anaerobic; Bacteriological Techniques; Cesarean Section; Child; C | 1984 |
Trials
3 trials available for cimetidine and Cancer of Colon
Article | Year |
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Omeprazole is more effective than a histamine H2-receptor blocker for maintaining a persistent elevation of gastric pH after colon resection for cancer.
Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cimetidine; Colonic Neoplasms; Female; Gastric Ac | 2004 |
Cimetidine and survival with colorectal cancer.
Topics: CD8-Positive T-Lymphocytes; Cimetidine; Colonic Neoplasms; Combined Modality Therapy; Disease-Free S | 1995 |
Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cimetidine; Colonic Neoplasm | 1995 |
Other Studies
22 other studies available for cimetidine and Cancer of Colon
Article | Year |
---|---|
[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Antimetabolites, Antineoplastic; Cimetidine; Colonic N | 2003 |
Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cimetidine; Colonic Neoplasms; Male; Mice; Mice, | 2003 |
Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.
Topics: Adenocarcinoma; Adult; Antigens, Surface; Cells, Cultured; Cimetidine; Colonic Neoplasms; Crohn Dise | 1984 |
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu | 1983 |
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic | 1984 |
The role of histamine antagonists on the development of experimental cancer in the rat.
Topics: Animals; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Diphenhydramine; Neoplasm Staging; Rats; | 1984 |
Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors.
Topics: Amidines; Animals; Cimetidine; Colonic Neoplasms; Female; Guanidines; Humans; Kinetics; Male; Mice; | 1981 |
[Preventive measures in gastroenterology].
Topics: Cimetidine; Colonic Neoplasms; Diarrhea; Doxycycline; Esophageal and Gastric Varices; Gastrointestin | 1981 |
Update in gastroenterology.
Topics: Adult; Cimetidine; Colonic Neoplasms; Flatulence; Humans; Intestinal Polyps; Peptic Ulcer | 1981 |
Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth.
Topics: Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cyclic AMP; Drug Screening Assays, Antitumor; | 1994 |
The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Cell Division; Chi-Square Distribut | 1993 |
Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cyclic AMP; Drug Interactions | 1996 |
Cimetidine: an inhibitor or promoter of tumor growth?
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Femal | 1999 |
Effect of cimetidine on intratumoral cytokine expression in an experimental tumor.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cytokines; Histamine; Histami | 2001 |
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
Topics: Adrenergic Agonists; Animals; Biogenic Amines; Cimetidine; Colonic Neoplasms; Female; Humans; Mice; | 1979 |
Cell proliferation in dimethylhydrazine-induced colonic adenocarcinomata following cytotoxic drug treatment.
Topics: 5,7-Dihydroxytryptamine; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cimetidine; | 1978 |
Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colon; Colonic Neoplasms; Dimethylhydrazines; Hi | 1978 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas | 1990 |
Synergistic antitumor activity of interleukin-2 and cimetidine against syngeneic murine tumor.
Topics: Adenocarcinoma; Animals; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Cimetidi | 1991 |
Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer.
Topics: Acute Disease; Adult; Aged; Cimetidine; Colonic Neoplasms; Drug Therapy, Combination; Duodenal Ulcer | 1986 |
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno | 1985 |
Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.
Topics: Adenocarcinoma; Aluminum; Cimetidine; Colonic Neoplasms; Fluorouracil; Gastric Mucosa; Humans; Infus | 1985 |