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cimetidine and Cancer of Colon

cimetidine has been researched along with Cancer of Colon in 27 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice."3.71Effect of cimetidine on intratumoral cytokine expression in an experimental tumor. ( Ichikawa, A; Takahashi, K; Tanaka, S, 2001)
"The histamine-2 receptor antagonist cimetidine (10(-5)M) and the prostaglandin synthesis inhibitor indomethacin (10(-8)M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma."3.67Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. ( Flodgren, P; Sjögren, HO, 1985)
"Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals."1.32Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. ( Izumi, K; Okabe, S; Tomita, K, 2003)
"Histamine has a trophic effect on at least two colorectal cancer cell lines in vivo and in vitro."1.29Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. ( Adams, WJ; Lawson, JA; Morris, DL, 1994)
"Colon cancer was induced in 40 Sprague Dawley rats using a 10-week course of 1,2 dimethylhydrazine (DMH)."1.29The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine. ( Adams, WJ; Cook, TA; Lawson, JA; Morris, DL; Nicholson, SE, 1993)
"Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells."1.29Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth. ( Adams, WJ; Lawson, JA; Morris, DL, 1996)
" So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy."1.27Postmarketing surveillance of the safety of cimetidine: 12 month mortality report. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Vessey, MP, 1983)
"Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis."1.27Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat. ( Caignard, A; Martin, F; Martin, M; Reisser, D; Thomas, B, 1984)
"Four lines of human colorectal cancer were established and serially propagated as subcutaneous xenographs in immunosuppressed inbred CBA/Lac mice."1.26Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors. ( Barkla, DH; Tutton, PJ, 1981)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199014 (51.85)18.7374
1990's8 (29.63)18.2507
2000's5 (18.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujiwara, S1
Noguchi, T2
Suehiro, S1
Kikuchi, R1
Uchida, Y1
Tomita, K1
Izumi, K1
Okabe, S1
Hsu, TC1
Su, CF1
Leu, SC1
Huang, PC1
Wang, TE1
Chu, CH1
Lefranc, F1
Yeaton, P1
Brotchi, J1
Kiss, R1
Doldi, K1
Manger, B1
Koch, B1
Riemann, J1
Hermanek, P1
Kalden, JR1
Simon, GL1
Gorbach, SL1
Colin-Jones, DG1
Langman, MJ1
Lawson, DH1
Vessey, MP1
Caignard, A1
Martin, M1
Reisser, D1
Thomas, B1
Martin, F1
Nee, J1
O'Higgins, N1
Osborne, DH1
Purdy, S1
Barkla, DH3
Tutton, PJ4
Ewe, K1
Matsumoto, S1
Svendsen, LB1
Ross, C1
Knigge, U1
Frederiksen, HJ1
Graversen, P1
Kjaergård, J1
Luke, M1
Stimpel, H1
Sparsø, BH1
Adams, WJ3
Lawson, JA3
Morris, DL3
Nicholson, SE1
Cook, TA1
Sasson, AR1
Gamagami, R1
An, Z1
Wang, X1
Moossa, AR1
Hoffman, RM1
Takahashi, K1
Tanaka, S1
Ichikawa, A1
Steel, GG1
Weiss, RB1
Donehower, RC1
Wiernik, PH1
Ohnuma, T1
Gralla, RJ1
Trump, DL1
Baker, JR1
Van Echo, DA1
Von Hoff, DD1
Leyland-Jones, B1
Nakajima, I1
Chu, TM1
Shike, M1
Gillin, JS1
Kemeny, N1
Daly, JM1
Kurtz, RC1
Flodgren, P1
Sjögren, HO1
Jewell, LD1
Fields, AL1
Murray, CJ1
Thomson, AB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090]Phase 327 participants (Actual)Interventional2020-02-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for cimetidine and Cancer of Colon

ArticleYear
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
    International journal of oncology, 2006, Volume: 28, Issue:5

    Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli

2006
Intestinal flora in health and disease.
    Gastroenterology, 1984, Volume: 86, Issue:1

    Topics: Adolescent; Adult; Aged; Bacteria, Anaerobic; Bacteriological Techniques; Cesarean Section; Child; C

1984

Trials

3 trials available for cimetidine and Cancer of Colon

ArticleYear
Omeprazole is more effective than a histamine H2-receptor blocker for maintaining a persistent elevation of gastric pH after colon resection for cancer.
    American journal of surgery, 2004, Volume: 187, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cimetidine; Colonic Neoplasms; Female; Gastric Ac

2004
Cimetidine and survival with colorectal cancer.
    Lancet (London, England), 1995, Jul-08, Volume: 346, Issue:8967

    Topics: CD8-Positive T-Lymphocytes; Cimetidine; Colonic Neoplasms; Combined Modality Therapy; Disease-Free S

1995
Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cimetidine; Colonic Neoplasm

1995

Other Studies

22 other studies available for cimetidine and Cancer of Colon

ArticleYear
[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:8

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Antimetabolites, Antineoplastic; Cimetidine; Colonic N

2003
Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice.
    Journal of pharmacological sciences, 2003, Volume: 93, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cimetidine; Colonic Neoplasms; Male; Mice; Mice,

2003
Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.
    Clinical and experimental immunology, 1984, Volume: 55, Issue:3

    Topics: Adenocarcinoma; Adult; Antigens, Surface; Cells, Cultured; Cimetidine; Colonic Neoplasms; Crohn Dise

1984
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
    British medical journal (Clinical research ed.), 1983, May-28, Volume: 286, Issue:6379

    Topics: Aged; Alcohol Drinking; Cimetidine; Colonic Neoplasms; England; Esophageal Neoplasms; Evaluation Stu

1983
Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat.
    British journal of cancer, 1984, Volume: 50, Issue:5

    Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Colonic

1984
The role of histamine antagonists on the development of experimental cancer in the rat.
    Irish journal of medical science, 1984, Volume: 153, Issue:10

    Topics: Animals; Cimetidine; Colonic Neoplasms; Dimethylhydrazines; Diphenhydramine; Neoplasm Staging; Rats;

1984
Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors.
    Journal of the National Cancer Institute, 1981, Volume: 67, Issue:6

    Topics: Amidines; Animals; Cimetidine; Colonic Neoplasms; Female; Guanidines; Humans; Kinetics; Male; Mice;

1981
[Preventive measures in gastroenterology].
    Der Internist, 1981, Volume: 22, Issue:2

    Topics: Cimetidine; Colonic Neoplasms; Diarrhea; Doxycycline; Esophageal and Gastric Varices; Gastrointestin

1981
Update in gastroenterology.
    Medical times, 1981, Volume: 109, Issue:2

    Topics: Adult; Cimetidine; Colonic Neoplasms; Flatulence; Humans; Intestinal Polyps; Peptic Ulcer

1981
Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth.
    Gut, 1994, Volume: 35, Issue:11

    Topics: Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cyclic AMP; Drug Screening Assays, Antitumor;

1994
The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1993, Volume: 19, Issue:4

    Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Cell Division; Chi-Square Distribut

1993
Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth.
    British journal of cancer, 1996, Volume: 73, Issue:7

    Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cyclic AMP; Drug Interactions

1996
Cimetidine: an inhibitor or promoter of tumor growth?
    International journal of cancer, 1999, May-31, Volume: 81, Issue:5

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Femal

1999
Effect of cimetidine on intratumoral cytokine expression in an experimental tumor.
    Biochemical and biophysical research communications, 2001, Volume: 281, Issue:5

    Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cytokines; Histamine; Histami

2001
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
    British journal of cancer, 1979, Volume: 40, Issue:5

    Topics: Adrenergic Agonists; Animals; Biogenic Amines; Cimetidine; Colonic Neoplasms; Female; Humans; Mice;

1979
Cell proliferation in dimethylhydrazine-induced colonic adenocarcinomata following cytotoxic drug treatment.
    Virchows Archiv. B, Cell pathology, 1978, Aug-25, Volume: 28, Issue:2

    Topics: 5,7-Dihydroxytryptamine; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cimetidine;

1978
Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.
    Cell biology international reports, 1978, Volume: 2, Issue:2

    Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colon; Colonic Neoplasms; Dimethylhydrazines; Hi

1978
Hypersensitivity reactions from taxol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:7

    Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas

1990
Synergistic antitumor activity of interleukin-2 and cimetidine against syngeneic murine tumor.
    Cancer immunology, immunotherapy : CII, 1991, Volume: 33, Issue:1

    Topics: Adenocarcinoma; Animals; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Cimetidi

1991
Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:3

    Topics: Acute Disease; Adult; Aged; Cimetidine; Colonic Neoplasms; Drug Therapy, Combination; Duodenal Ulcer

1986
Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.
    Cancer immunology, immunotherapy : CII, 1985, Volume: 19, Issue:1

    Topics: Antibody-Dependent Cell Cytotoxicity; Carcinoma; Cimetidine; Colonic Neoplasms; Cytotoxicity, Immuno

1985
Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:6

    Topics: Adenocarcinoma; Aluminum; Cimetidine; Colonic Neoplasms; Fluorouracil; Gastric Mucosa; Humans; Infus

1985
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