cimetidine and Benign Neoplasms, Brain
cimetidine has been researched along with Benign Neoplasms, Brain in 9 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 7.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| "Cimetidine added to temozolomide compared with temozolomide alone induced survival benefits in nude mice with U373 human glioblastoma multiforme (GBM) cells orthotopically xenografted in the brain." | 3.73 | Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts. ( Brotchi, J; Camby, I; Darro, F; Gabius, J; Gaussin, JF; James, S; Kiss, R; Lefranc, F, 2005) |
| "The authors studied the effect of intracarotid administration of histamine on the regional cerebral blood flow (rCBF) in transplanted rat C6 glioma by the hydrogen clearance method." | 3.68 | Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor. ( Fukui, M; Ikezaki, K; Natori, Y; Nomura, T, 1993) |
| "Cimetidine is an H2 blocker and has been shown to inhibit tumour cell growth." | 1.29 | Effect of histamine and the H2 antagonist cimetidine on the growth and migration of human neoplastic glia. ( Finn, PE; Pilkington, GJ; Purnell, P, 1996) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lefranc, F | 2 |
| James, S | 1 |
| Camby, I | 1 |
| Gaussin, JF | 1 |
| Darro, F | 1 |
| Brotchi, J | 2 |
| Gabius, J | 1 |
| Kiss, R | 2 |
| Yeaton, P | 1 |
| Bilynskiĭ, BT | 1 |
| Shparik, IaV | 1 |
| Volkin, RL | 1 |
| Shadduck, RK | 1 |
| Winkelstein, A | 1 |
| Zeigler, ZR | 1 |
| Selker, RG | 1 |
| Van der Ven, LT | 1 |
| Prinsen, IM | 1 |
| Jansen, GH | 1 |
| Roholl, PJ | 1 |
| Defferrari, R | 1 |
| Slater, R | 1 |
| Den Otter, W | 1 |
| Nomura, T | 1 |
| Ikezaki, K | 1 |
| Natori, Y | 1 |
| Fukui, M | 1 |
| Finn, PE | 1 |
| Purnell, P | 1 |
| Pilkington, GJ | 1 |
| Armitage, JO | 1 |
| Sidner, RD | 1 |
| Ross, AJ | 1 |
| Siegel, KR | 1 |
| Bell, W | 1 |
| Templeton, JM | 1 |
| Schnaufer, L | 1 |
| Bishop, HC | 1 |
Reviews
2 reviews available for cimetidine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).
Topics: Antineoplastic Agents; Brain Neoplasms; Cimetidine; Clinical Trials as Topic; Colonic Neoplasms; Gli | 2006 |
[Carcinogenicity of various drugs].
Topics: Adult; Animals; Anti-Bacterial Agents; Arsenicals; Barbiturates; Brain Neoplasms; Carcinogens; Child | 1984 |
Other Studies
7 other studies available for cimetidine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Combined cimetidine and temozolomide, compared with temozolomide alone: significant increases in survival in nude mice bearing U373 human glioblastoma multiforme orthotopic xenografts.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cimetidine; Dac | 2005 |
Potentiation of carmustine-cranial irradiation-induced myelosuppression by cimetidine.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Cimetidine; Drug Synergism; Female; Glioma; Guanidines; He | 1982 |
Growth of cultured human glioma tumour cells can be regulated with histamine and histamine antagonists.
Topics: Adult; Aged; Brain Neoplasms; Cell Division; Cell Survival; Cimetidine; DNA, Neoplasm; Female; Gliom | 1993 |
Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cerebral Arte | 1993 |
Effect of histamine and the H2 antagonist cimetidine on the growth and migration of human neoplastic glia.
Topics: Brain Neoplasms; Cell Cycle; Cell Movement; Cimetidine; Depression, Chemical; Glioma; Histamine; His | 1996 |
Antitumour effect of cimetidine.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Cimetidine; Female | 1979 |
Massive gastrointestinal hemorrhage in children with posterior fossa tumors.
Topics: Antacids; Brain Neoplasms; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Child, Preschool; Cim | 1987 |