Page last updated: 2024-10-23
berberine and Sepsis
berberine has been researched along with Sepsis in 19 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis." | 7.91 | Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis. ( Feng, A; He, Y; Li, X; Sun, Y; Yuan, X; Zuo, H, 2019) |
| "The rat cecal ligation and puncture (CLP) sepsis model was employed to evaluate the effect of berberine on serum endotoxin level and intestinal vascular permeability to Evans blue in vivo." | 7.88 | Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis. ( Feng, A; He, Y; Sun, Y; Yuan, X; Zuo, H, 2018) |
| "Previous study had elucidated the effective components from HJD with high affinity to lipid A, which can generate the release of pro-inflammatory-cytokines, resulting in sepsis." | 7.85 | Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction. ( Chen, G; Dou, D; Guo, S; Xu, Y; Zhang, M; Zhang, X, 2017) |
| "Sepsis is defined as a dysregulated immune response to infection that leads to multiple organ dysfunction." | 7.01 | Berberine in Sepsis: Effects, Mechanisms, and Therapeutic Strategies. ( Hu, L; Li, S; Lv, T; Qi, W; Wang, C; Wang, H; Zhang, C, 2023) |
| "Sepsis is a deadly complication raised by bacterial pathogens-induced dysregulated innate inflammatory response." | 5.56 | Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation. ( Du, P; Jiang, D; Wang, Y, 2020) |
| " In the present study, we investigated the effects of berberine in combination with yohimbine (BY) on neutrophil tissue infiltration and multiple organ damage during sepsis, and further elucidated the involved mechanisms." | 5.43 | Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils. ( Li, H; Lu, D; Lv, X; Tang, X; Wang, F; Wang, H; Wang, Y; Yang, D, 2016) |
| "The present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis." | 3.91 | Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis. ( Feng, A; He, Y; Li, X; Sun, Y; Yuan, X; Zuo, H, 2019) |
| "The rat cecal ligation and puncture (CLP) sepsis model was employed to evaluate the effect of berberine on serum endotoxin level and intestinal vascular permeability to Evans blue in vivo." | 3.88 | Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis. ( Feng, A; He, Y; Sun, Y; Yuan, X; Zuo, H, 2018) |
| "Previous study had elucidated the effective components from HJD with high affinity to lipid A, which can generate the release of pro-inflammatory-cytokines, resulting in sepsis." | 3.85 | Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction. ( Chen, G; Dou, D; Guo, S; Xu, Y; Zhang, M; Zhang, X, 2017) |
| "Berberine was reported to protect against the intestinal injury and improve the survival rate in sepsis, and glutamine deficiency was considered to be correlated with mortality in sepsis." | 3.77 | Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat. ( Gong, J; Hu, Z; Huang, Q; Li, J; Li, N; Li, Q; Niu, L; Qiao, W; Zhu, W, 2011) |
| "Sepsis is defined as a dysregulated immune response to infection that leads to multiple organ dysfunction." | 3.01 | Berberine in Sepsis: Effects, Mechanisms, and Therapeutic Strategies. ( Hu, L; Li, S; Lv, T; Qi, W; Wang, C; Wang, H; Zhang, C, 2023) |
| "Berberine (BBR) is an alkaloid compound extracted from herbs, which has anti-inflammatory, anti-oxidative effects and can be used in intestinal infectious diseases and inflammatory bowel disease (IBD)." | 1.72 | Berberine suppresses cecal ligation and puncture induced intestinal injury by enhancing Treg cell function. ( Cai, D; Qiu, D; Song, Z; Tong, C; Xue, M; Yang, Y; Zhang, W; Zhang, Y, 2022) |
| "Sepsis is a deadly complication raised by bacterial pathogens-induced dysregulated innate inflammatory response." | 1.56 | Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation. ( Du, P; Jiang, D; Wang, Y, 2020) |
| " In the present study, we investigated the effects of berberine in combination with yohimbine (BY) on neutrophil tissue infiltration and multiple organ damage during sepsis, and further elucidated the involved mechanisms." | 1.43 | Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils. ( Li, H; Lu, D; Lv, X; Tang, X; Wang, F; Wang, H; Wang, Y; Yang, D, 2016) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 8 (42.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Qiu, D | 1 |
| Zhang, W | 1 |
| Song, Z | 1 |
| Xue, M | 1 |
| Zhang, Y | 1 |
| Yang, Y | 1 |
| Tong, C | 1 |
| Cai, D | 1 |
| Izadparast, F | 1 |
| Riahi-Zajani, B | 1 |
| Yarmohammadi, F | 1 |
| Hayes, AW | 1 |
| Karimi, G | 1 |
| Lv, T | 1 |
| Zhang, C | 1 |
| Hu, L | 1 |
| Wang, C | 1 |
| Li, S | 1 |
| Wang, H | 3 |
| Qi, W | 1 |
| Chen, L | 1 |
| Liu, X | 1 |
| Wang, X | 1 |
| Lu, Z | 1 |
| Ye, Y | 1 |
| Li, X | 2 |
| Bai, Y | 1 |
| Ma, Y | 1 |
| Li, Y | 2 |
| Wang, Y | 3 |
| Du, P | 1 |
| Jiang, D | 1 |
| Fan, TT | 1 |
| Cheng, BL | 1 |
| Fang, XM | 1 |
| Chen, YC | 1 |
| Su, F | 1 |
| Zhou, J | 1 |
| Qiu, J | 1 |
| Huang, Z | 1 |
| Wang, W | 1 |
| Wu, P | 1 |
| Feng, A | 3 |
| Lv, Y | 1 |
| Wang, J | 2 |
| Xu, D | 1 |
| Liao, S | 1 |
| Li, P | 1 |
| Zhang, Q | 1 |
| Yang, M | 1 |
| Kong, L | 1 |
| Xu, Y | 1 |
| Guo, S | 1 |
| Chen, G | 1 |
| Zhang, M | 1 |
| Zhang, X | 2 |
| Dou, D | 1 |
| He, Y | 2 |
| Yuan, X | 2 |
| Zuo, H | 2 |
| Sun, Y | 2 |
| Li, GX | 1 |
| Wang, XM | 1 |
| Jiang, T | 1 |
| Gong, JF | 1 |
| Niu, LY | 1 |
| Li, N | 2 |
| Ma, ST | 1 |
| Feng, CT | 1 |
| Dai, GL | 1 |
| Song, Y | 1 |
| Zhou, GL | 1 |
| Zhang, XL | 1 |
| Miao, CG | 1 |
| Yu, H | 1 |
| Ju, WZ | 1 |
| Chen, GR | 1 |
| Zhang, G | 1 |
| Li, MY | 1 |
| Jing, J | 1 |
| Mackie, B | 1 |
| Dou, DQ | 1 |
| Wang, F | 1 |
| Yang, D | 1 |
| Tang, X | 1 |
| Li, H | 3 |
| Lv, X | 1 |
| Lu, D | 2 |
| Chang, KC | 1 |
| Ko, YS | 1 |
| Kim, HJ | 1 |
| Nam, DY | 1 |
| Lee, DU | 1 |
| Niu, L | 1 |
| Qiao, W | 1 |
| Hu, Z | 1 |
| Huang, Q | 1 |
| Gong, J | 1 |
| Li, Q | 1 |
| Zhu, W | 1 |
| Li, J | 1 |
| Zhang, H | 1 |
| Jia, B | 1 |
| Wang, D | 1 |
| Qi, R | 1 |
| Yan, Y | 1 |
Reviews
4 reviews available for berberine and Sepsis
| Article | Year |
|---|---|
Protective effect of berberine against LPS-induced injury in the intestine: a review.
Topics: Adenocarcinoma; Animals; Berberine; Caco-2 Cells; Colonic Neoplasms; Cyclooxygenase 2; Humans; Intes | 2022 |
Berberine in Sepsis: Effects, Mechanisms, and Therapeutic Strategies.
Topics: Animals; Berberine; Medicine, Chinese Traditional; Sepsis | 2023 |
Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide: molecular mechanisms and preclinical evidence.
Topics: Acute Lung Injury; Anti-Inflammatory Agents; Berberine; Humans; Inflammation; Lipopolysaccharides; L | 2023 |
Application of Chinese Medicine in the Management of Critical Conditions: A Review on Sepsis.
Topics: Anti-Inflammatory Agents; Artemisinins; Astragalus propinquus; Berberine; Betacoronavirus; Coronavir | 2020 |
Other Studies
15 other studies available for berberine and Sepsis
| Article | Year |
|---|---|
Berberine suppresses cecal ligation and puncture induced intestinal injury by enhancing Treg cell function.
Topics: Animals; Berberine; Cecum; Ligation; Mice; Punctures; Sepsis; T-Lymphocytes, Regulatory | 2022 |
Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling.
Topics: Acute Lung Injury; Animals; Berberine; Homeostasis; Lung; Mice; NF-kappa B; Sepsis; Signal Transduct | 2023 |
Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation.
Topics: Animals; Berberine; Disease Models, Animal; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; Se | 2020 |
Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis.
Topics: Animals; Apolipoproteins M; Berberine; Capillary Permeability; Disease Models, Animal; Gastrointesti | 2020 |
Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling.
Topics: Acute Disease; Animals; Berberine; Drugs, Chinese Herbal; Humans; Liver; Rats; Rats, Sprague-Dawley; | 2017 |
Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
Topics: Animals; Berberine; Berberine Alkaloids; Cell Line; Drugs, Chinese Herbal; Flavonoids; Interleukin-6 | 2017 |
Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis.
Topics: Animals; Antigens, CD; Berberine; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cadherins; | 2018 |
Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis.
Topics: Animals; Berberine; Caco-2 Cells; Cation Transport Proteins; Cell Membrane Permeability; Coinfection | 2019 |
Berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway.
Topics: Animals; Berberine; Carrier Proteins; Cell Death; Claudin-4; Gene Expression Regulation; Interleukin | 2014 |
In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang (HLJDD) and elucidating molecular mechanisms for the treatment of sepsis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Berberine; Dinoprostone; Drugs, Chinese Herbal; Humans; KB | 2015 |
The effective components of Huanglian Jiedu Decoction against sepsis evaluated by a lipid A-based affinity biosensor.
Topics: Animals; Berberine; Biosensing Techniques; Drugs, Chinese Herbal; Female; Flavonoids; Interleukin-6; | 2016 |
Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of CCR2 expression in neutrophils.
Topics: Animals; Antibodies, Blocking; Berberine; Cecum; Cell Movement; Cells, Cultured; Disease Models, Ani | 2016 |
13-Methylberberine reduces HMGB1 release in LPS-activated RAW264.7 cells and increases the survival of septic mice through AMPK/P38 MAPK activation.
Topics: AMP-Activated Protein Kinases; Animals; Aorta, Thoracic; Berberine; HMGB1 Protein; In Vitro Techniqu | 2016 |
Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat.
Topics: Amino Acid Transport Systems, Neutral; Animals; Berberine; Biological Transport; Glutaminase; Glutam | 2011 |
Yohimbine enhances protection of berberine against LPS-induced mouse lethality through multiple mechanisms.
Topics: Animals; Berberine; Cells, Cultured; Drug Synergism; Lipopolysaccharides; Macrophages, Peritoneal; M | 2012 |