Page last updated: 2024-10-23

azathioprine and Gout

azathioprine has been researched along with Gout in 30 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Research Excerpts

ExcerptRelevanceReference
"To describe the use of azathioprine or other immunosuppressive therapies as a pegloticase adjunct to prevent pegloticase immunogenicity when treating gout."3.85Pegloticase failure and a possible solution: Immunosuppression to prevent intolerance and inefficacy in patients with gout. ( Berhanu, AA; Keenan, RT; Krasnokutsky, S; Pillinger, MH, 2017)
"To evaluate the frequency and the pathogenesis of hyperuricemia and gout during cyclosporine therapy, we studied renal-transplant recipients who were treated with either cyclosporine and prednisone (n = 129) or azathioprine and prednisone (n = 168)."3.67Cyclosporine-induced hyperuricemia and gout. ( Fox, IH; Lin, HY; McQuillan, MA; Palella, TD; Rocher, LL; Schmaltz, S, 1989)
"Similarity of the morphological picture of gouty nephropathy and primary glomerulonephritides in which purine antagonists turned out to be effective, a positive effect of azathioprine (Az) and 6-mercaptopurine (MP) on purine metabolism, and changes in immunity indices revealed in gout (hyperproduction of immunoglobulins and circulating immune complexes) necessitates the use of antimetabolites in combined therapy of gout patients with proteinuric and latent types of nephropathy."3.67[Substantiation and effectiveness of the use of purine antagonists in gouty nephropathy]. ( Diadyk, AI; Nikolenko, IuI; Shpilevaia, NI; Siniachenko, OV; Vasilenko, IV, 1987)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199019 (63.33)18.7374
1990's5 (16.67)18.2507
2000's2 (6.67)29.6817
2010's3 (10.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Keenan, RT2
Botson, JK1
Masri, KR1
Padnick-Silver, L1
LaMoreaux, B1
Albert, JA1
Pillinger, MH2
Weiler, S1
Aellig, N1
Fauchère, I1
Jetter, A1
Corti, N1
Berhanu, AA1
Krasnokutsky, S1
Lam, MY1
Feller, ER1
Lonks, JR1
Shah, SA1
Kaczmorski, S1
Doares, W1
Winfrey, S1
Al-Geizawi, S1
Farney, A1
Rogers, J1
Stratta, R1
Edwards, NL1
Sorensen, LB2
Benke, PJ1
Ben Hmida, M1
Hachicha, J1
Bahloul, Z1
Kaddour, N1
Kharrat, M1
Jarraya, F1
Jarraya, A1
Schumacher, HR1
Perez-Ruiz, F1
Alonso-Ruiz, A1
Calabozo, M1
Duruelo, J1
Westberg, NG1
Rosén, E1
Waldenström, J1
Glogner, P1
Heni, N1
Müller, MM1
Kaiser, E1
Delaney, V1
Sumrani, N1
Daskalakis, P1
Hong, JH1
Sommer, BG1
Lin, HY1
Rocher, LL1
McQuillan, MA1
Schmaltz, S1
Palella, TD1
Fox, IH1
Tiller, DJ1
Hall, BM1
Horvarth, JS1
Duggin, GG1
Thompson, JF1
Sheil, AG1
Gores, PF1
Fryd, DS1
Sutherland, DE1
Najarian, JS1
Simmons, RL1
West, C1
Carpenter, BJ1
Hakala, TR1
Siniachenko, OV1
Diadyk, AI1
Nikolenko, IuI1
Vasilenko, IV1
Shpilevaia, NI1
Bach, JF2
Bach, MA2
Dardenne, M2
Huskisson, EC1
Klein, G2
Fellner, S1
Fellner, R1
Kölle, G1
Stoeber, E1
Schöntag, W1
Kelley, WN1
Greene, ML2
Rosenbloom, FM1
Henderson, JF1
Seegmiller, JE2
Glueck, CJ1
Fujimoto, WY1
Nyhan, WL1
Sweetman, L1
Carpenter, DG1
Carter, CH1
Hoefnagel, D1

Reviews

3 reviews available for azathioprine and Gout

ArticleYear
The effect of immunomodulators on the efficacy and tolerability of pegloticase: a systematic review.
    Seminars in arthritis and rheumatism, 2021, Volume: 51, Issue:2

    Topics: Azathioprine; Gout; Gout Suppressants; Humans; Immunologic Factors; Polyethylene Glycols; Urate Oxid

2021
Crystal deposition disease.
    Current opinion in rheumatology, 1997, Volume: 9, Issue:3

    Topics: Antirheumatic Agents; Azathioprine; Chondrocalcinosis; Colchicine; Cyclosporine; Gout; Gout Suppress

1997
Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout.
    Annals of internal medicine, 1969, Volume: 70, Issue:1

    Topics: Adenine; Adolescent; Adult; Allopurinol; Azathioprine; Child; Child, Preschool; Female; Gout; Humans

1969

Trials

3 trials available for azathioprine and Gout

ArticleYear
Hyperuricemia and gout in renal allograft recipients.
    Transplantation proceedings, 1992, Volume: 24, Issue:5

    Topics: Adult; Azathioprine; Cyclosporine; Gout; Humans; Kidney Transplantation; Risk Factors; Transplantati

1992
Hyperuricemia after renal transplantation.
    American journal of surgery, 1988, Volume: 156, Issue:5

    Topics: Antilymphocyte Serum; Azathioprine; Clinical Trials as Topic; Cyclosporins; Drug Therapy, Combinatio

1988
[Indomethacin in rheumatic diseases with special reference to ophthalmologic studies].
    Medizinische Klinik, 1972, Feb-25, Volume: 67, Issue:8

    Topics: Allopurinol; Arthritis, Rheumatoid; Azathioprine; Blood Cells; Capsules; Clinical Trials as Topic; E

1972

Other Studies

24 other studies available for azathioprine and Gout

ArticleYear
Treatment of gout in a renal transplant patient leading to severe thrombocytopenia.
    Journal of clinical pharmacy and therapeutics, 2014, Volume: 39, Issue:5

    Topics: Aged; Allopurinol; Azathioprine; Diagnosis, Differential; Female; Gout; Gout Suppressants; Humans; I

2014
Pegloticase failure and a possible solution: Immunosuppression to prevent intolerance and inefficacy in patients with gout.
    Seminars in arthritis and rheumatism, 2017, Volume: 46, Issue:6

    Topics: Azathioprine; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Immunosuppressive Agents;

2017
Inflammatory bowel disease potpourri: a vignette-based discussion.
    Medicine and health, Rhode Island, 2009, Volume: 92, Issue:4

    Topics: Adult; Allopurinol; Azathioprine; Clostridioides difficile; Colitis, Ulcerative; Crohn Disease; Drug

2009
Gout and transplantation: new treatment option-same old drug interaction.
    Transplantation, 2011, Aug-15, Volume: 92, Issue:3

    Topics: Aged; Azathioprine; Drug Interactions; Febuxostat; Gout; Gout Suppressants; Graft Rejection; Humans;

2011
Case 9: initiation of urate-lowering therapy for advanced gout complicated by chronic renal insufficiency.
    The American journal of medicine, 2006, Volume: 119, Issue:11 Suppl 1

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Contraindications; Drug Interact

2006
Biochemical evidence for a distinct type of primary gout.
    Nature, 1967, Mar-18, Volume: 213, Issue:5081

    Topics: Adolescent; Allopurinol; Azathioprine; Carbon; Carbon Isotopes; Enzymes; Glycine; Gout; Humans; Hypo

1967
Cyclosporine-induced hyperuricemia and gout in renal transplants.
    Transplantation proceedings, 1995, Volume: 27, Issue:5

    Topics: Adult; Allopurinol; Azathioprine; Cyclosporine; Drug Interactions; Gout; Gout Suppressants; Humans;

1995
Treatment of gout after transplantation.
    British journal of rheumatology, 1998, Volume: 37, Issue:5

    Topics: Allopurinol; Azathioprine; Cyclosporine; Diuretics; Drug Interactions; Furosemide; Gout; Gout Suppre

1998
Recessive X-linked hyperuricemia with gout and renal damage, normal activity of hypoxanthine phosphoribosyltransferase and resistance to azaguanine.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:3

    Topics: Adenine Phosphoribosyltransferase; Adolescent; Adult; Azaguanine; Azathioprine; Erythrocytes; Female

1979
[Pancytopenia following combination treatment with allopurinol and azathioprine].
    Die Medizinische Welt, 1976, Aug-13, Volume: 27, Issue:33

    Topics: Allopurinol; Anemia, Aplastic; Azathioprine; Drug Interactions; Drug Therapy, Combination; Gout; Hum

1976
[Regulation of purine metabolism and its modification by drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Jan-31, Volume: 100, Issue:5

    Topics: Allopurinol; Antimetabolites; Azathioprine; Benzofurans; Chemical Phenomena; Chemistry; Erythrocytes

1975
Cyclosporine-induced hyperuricemia and gout.
    The New England journal of medicine, 1990, Feb-01, Volume: 322, Issue:5

    Topics: Allopurinol; Azathioprine; Cyclosporins; Drug Interactions; Gout; Humans; Transplantation, Homologou

1990
Cyclosporine-induced hyperuricemia and gout.
    The New England journal of medicine, 1989, Aug-03, Volume: 321, Issue:5

    Topics: Adult; Arthritis, Gouty; Azathioprine; Creatinine; Cyclosporins; Drug Therapy, Combination; Female;

1989
Gout and hyperuricaemia in patients on cyclosporin and diuretics.
    Lancet (London, England), 1985, Feb-23, Volume: 1, Issue:8426

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Cyclosporins; Diuretics; Female; Gout; Humans; Kidney Dis

1985
The incidence of gout in renal transplant recipients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 10, Issue:5

    Topics: Azathioprine; Cyclosporins; Diuretics; Female; Gout; Humans; Kidney Transplantation; Male; Retrospec

1987
[Substantiation and effectiveness of the use of purine antagonists in gouty nephropathy].
    Terapevticheskii arkhiv, 1987, Volume: 59, Issue:12

    Topics: Adult; Azathioprine; Drug Therapy, Combination; Gout; Humans; Kidney Diseases; Mercaptopurine; Middl

1987
The use of certain immunosuppressive drugs in the clinical study of gout.
    Advances in nephrology from the Necker Hospital, 1974, Volume: 3

    Topics: Azathioprine; Erythrocytes; Gout; Humans; Immune Adherence Reaction; Lymphocyte Culture Test, Mixed;

1974
Recent drugs and the rheumatic diseases.
    Reports on rheumatic diseases, 1974, Issue:54

    Topics: Acetaminophen; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-

1974
[Immunosuppressive agents in the basic therapy of visceral forms of rheumatoid arthritis in children].
    Medizinische Klinik, 1972, Apr-28, Volume: 67, Issue:17

    Topics: Adolescent; Adrenal Cortex Hormones; Amyloidosis; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathi

1972
[Determination of active metabolites of immunosuppressive agents in the serum. Application to azathioprine].
    La Nouvelle presse medicale, 1972, Oct-07, Volume: 1, Issue:35

    Topics: Anemia, Aplastic; Azathioprine; Gout; Hepatitis; Histocompatibility Testing; Humans; Immune Adherenc

1972
[Long-term studies on indomethacin in rheumatology with special reference to its use in combination with azathioprine].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:11

    Topics: Administration, Oral; Arthritis; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Drug Combinat

1971
Suppression of the shunt pathway in primary gout by azathioprine.
    Proceedings of the National Academy of Sciences of the United States of America, 1966, Volume: 55, Issue:3

    Topics: Adenine Nucleotides; Azathioprine; Blood; Enzyme Repression; Glycine; Gout; Guanine Nucleotides; Hum

1966
Benign symmetric lipomatosis (Launois-Bensaude adenolipomatosis) with gout and hyperlipoproteinemia.
    The American journal of medicine, 1970, Volume: 48, Issue:2

    Topics: Adult; Azathioprine; Blood Protein Electrophoresis; Carbon Isotopes; Female; Glucose Tolerance Test;

1970
Effects of azathiprine in a disorder of uric acid metabolism and cerebral function.
    The Journal of pediatrics, 1968, Volume: 72, Issue:1

    Topics: Adult; Azathioprine; Blood Platelets; Brain Diseases; Child; Gout; Hematocrit; Hemoglobinometry; Hum

1968