adenine has been researched along with Sepsis in 16 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study demonstrates that INT-777 treatment reduced neuroinflammation and microglial cell activation, but improved cognitive impairment in the experimental sepsis rats." | 8.02 | INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis. ( Deng, S; Gao, Y; Gong, Y; Jin, P; Lenahan, C; Tan, J; Tian, M; Wang, Y; Wei, P; Wen, H; Zhao, F, 2021) |
| " The aim of this study was to verify the hypothesis that adenosine deaminase-1 and cyclic guanosine monophosphate-stimulated phosphodiesterase inhibition by erythro-9-[2-hydroxyl-3-nonyl]-adenine could be beneficial in experimental endotoxicosis/sepsis." | 7.74 | The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation. ( Bardenheuer, H; Conzelmann, LO; Funke, B; Hofer, S; Kayhan, N; Schmidt, H; Steppan, J; Vahl, CF; Weigand, MA; Winkler, H, 2008) |
| "Sinomenine (SIN) is a natural alkaloid extracted from Chinese medicinal plant Sinomenium acutum, and its hydrochloride salt (Sinomenine hydrochloride, SIN-HCl) is widely used to treat rheumatoid arthritis (RA)." | 5.42 | Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy. ( Chen, G; Gao, M; Jiang, Y; Lang, Y; Liu, M; Tong, Z; Wang, K; Wang, W; Xiao, X; Yao, Y; Zhang, H, 2015) |
| "This study demonstrates that INT-777 treatment reduced neuroinflammation and microglial cell activation, but improved cognitive impairment in the experimental sepsis rats." | 4.02 | INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis. ( Deng, S; Gao, Y; Gong, Y; Jin, P; Lenahan, C; Tan, J; Tian, M; Wang, Y; Wei, P; Wen, H; Zhao, F, 2021) |
| " The aim of this study was to verify the hypothesis that adenosine deaminase-1 and cyclic guanosine monophosphate-stimulated phosphodiesterase inhibition by erythro-9-[2-hydroxyl-3-nonyl]-adenine could be beneficial in experimental endotoxicosis/sepsis." | 3.74 | The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation. ( Bardenheuer, H; Conzelmann, LO; Funke, B; Hofer, S; Kayhan, N; Schmidt, H; Steppan, J; Vahl, CF; Weigand, MA; Winkler, H, 2008) |
| "Sepsis is a life-threatening condition which affects multiple organs including the kidney." | 1.62 | Bruton's tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice. ( Ahmad, SF; Al-Harbi, NO; Alanazi, WA; Alqahtani, F; Alsanea, S; Attia, SM; Ibrahim, KE; Mahmood, HM; Nadeem, A, 2021) |
| "Sepsis is one of the most prevalent diseases in the world." | 1.51 | Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. ( Al Zoubi, S; Chiazza, F; Coldewey, SM; Collino, M; Collotta, D; Martin, L; O'Riordan, CE; Purvis, GSD; Stiehler, L; Thiemermann, C; Wissuwa, B, 2019) |
| "Sinomenine (SIN) is a natural alkaloid extracted from Chinese medicinal plant Sinomenium acutum, and its hydrochloride salt (Sinomenine hydrochloride, SIN-HCl) is widely used to treat rheumatoid arthritis (RA)." | 1.42 | Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy. ( Chen, G; Gao, M; Jiang, Y; Lang, Y; Liu, M; Tong, Z; Wang, K; Wang, W; Xiao, X; Yao, Y; Zhang, H, 2015) |
| "Sepsis was induced by cecal ligation and puncture (CLP)." | 1.40 | Complete activation of autophagic process attenuates liver injury and improves survival in septic mice. ( Chang, YF; Hsieh, YC; Kuo, PL; Lee, PH; Lin, CW; Lo, S; Perng, DS; Wu, DB; Yu, ML; Yuan, SS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 6 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| O'Riordan, CE | 2 |
| Purvis, GSD | 2 |
| Collotta, D | 2 |
| Chiazza, F | 1 |
| Wissuwa, B | 2 |
| Al Zoubi, S | 1 |
| Stiehler, L | 1 |
| Martin, L | 1 |
| Coldewey, SM | 2 |
| Collino, M | 2 |
| Thiemermann, C | 2 |
| Jin, P | 1 |
| Deng, S | 1 |
| Tian, M | 1 |
| Lenahan, C | 1 |
| Wei, P | 1 |
| Wang, Y | 1 |
| Tan, J | 1 |
| Wen, H | 1 |
| Zhao, F | 1 |
| Gao, Y | 1 |
| Gong, Y | 1 |
| Wang, X | 2 |
| Zhu, Y | 1 |
| Zhou, Q | 1 |
| Yan, Y | 1 |
| Qu, J | 1 |
| Ye, H | 1 |
| Krieg, N | 1 |
| Sheikh, MH | 1 |
| Ferreira Alves, G | 1 |
| Mohammad, S | 1 |
| Callender, LA | 1 |
| Greaves, DR | 1 |
| Nadeem, A | 1 |
| Ahmad, SF | 1 |
| Al-Harbi, NO | 1 |
| Ibrahim, KE | 1 |
| Alqahtani, F | 1 |
| Alanazi, WA | 1 |
| Mahmood, HM | 1 |
| Alsanea, S | 1 |
| Attia, SM | 1 |
| Saling, C | 1 |
| Feller, F | 1 |
| Vikram, HR | 1 |
| Tang, R | 1 |
| Jia, L | 1 |
| Li, Y | 1 |
| Zheng, J | 1 |
| Qi, P | 1 |
| Li, Q | 1 |
| Li, L | 1 |
| Fei, X | 1 |
| Zhang, Y | 1 |
| Qi, C | 1 |
| Hua, S | 1 |
| Gong, F | 1 |
| Fang, M | 1 |
| Chen, J | 1 |
| Min, S | 1 |
| Xie, F | 1 |
| Yang, J | 1 |
| Lin, CW | 1 |
| Lo, S | 1 |
| Perng, DS | 1 |
| Wu, DB | 1 |
| Lee, PH | 1 |
| Chang, YF | 1 |
| Kuo, PL | 1 |
| Yu, ML | 1 |
| Yuan, SS | 1 |
| Hsieh, YC | 1 |
| Jiang, Y | 1 |
| Gao, M | 1 |
| Wang, W | 1 |
| Lang, Y | 1 |
| Tong, Z | 1 |
| Wang, K | 1 |
| Zhang, H | 1 |
| Chen, G | 1 |
| Liu, M | 1 |
| Yao, Y | 1 |
| Xiao, X | 1 |
| Kayhan, N | 1 |
| Funke, B | 1 |
| Conzelmann, LO | 1 |
| Winkler, H | 1 |
| Hofer, S | 1 |
| Steppan, J | 1 |
| Schmidt, H | 1 |
| Bardenheuer, H | 1 |
| Vahl, CF | 1 |
| Weigand, MA | 1 |
| Williams, M | 1 |
| Kerkar, S | 1 |
| Tyburski, JG | 1 |
| Steffes, CP | 1 |
| Carlin, AM | 1 |
| Wilson, RF | 1 |
| Conlon, BA | 1 |
| Law, WR | 1 |
| Fitzgerald, RD | 1 |
| Martin, CM | 1 |
| Dietz, GE | 1 |
| Doig, GS | 1 |
| Potter, RF | 1 |
| Sibbald, WJ | 1 |
| Harbrecht, BG | 1 |
| Taylor, BS | 1 |
| Xu, Z | 1 |
| Ramalakshmi, S | 1 |
| Ganster, RW | 1 |
| Geller, DA | 1 |
16 other studies available for adenine and Sepsis
| Article | Year |
|---|---|
Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Benzamides; Cecum; Disease Models, Animal; He | 2019 |
INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis.
Topics: Adenine; Animals; Anxiety; Cholic Acids; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Elem | 2021 |
Heat shock protein 70 expression protects against sepsis-associated cardiomyopathy by inhibiting autophagy.
Topics: Adenine; Animals; Autophagy; Cardiomyopathies; HSP70 Heat-Shock Proteins; Humans; Male; Models, Anim | 2021 |
X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Benzamides; Disease Models, Animal; Inflammas | 2020 |
Bruton's tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice.
Topics: Acute Kidney Injury; Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; B-Lymphocytes; Dendritic | 2021 |
Ibrutinib-associated necrotic nasal lesion and pulmonary infiltrates.
Topics: Adenine; Aged; Ecthyma; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Necrosis; Piperidine | 2021 |
Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy.
Topics: Adenine; Amaryllidaceae Alkaloids; Animals; Autophagy; Inflammation; Lipopolysaccharides; Male; MAP | 2021 |
Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis.
Topics: Adenine; Animals; Autophagy; Carrier Proteins; Endotoxemia; Interleukin-6; Lipopolysaccharides; Male | 2018 |
Enhancing Autophagy Protects Against Sepsis-Induced Neuromuscular Dysfunction Associated with Qualitative Changes to Acetylcholine Receptors.
Topics: Adenine; Animals; Autophagy; Cecum; Ligation; Male; Punctures; Rats; Rats, Sprague-Dawley; Receptors | 2019 |
Complete activation of autophagic process attenuates liver injury and improves survival in septic mice.
Topics: Adenine; Amebicides; Animals; Anticonvulsants; Autophagy; Carbamazepine; Chloroquine; Liver; Lysosom | 2014 |
Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy.
Topics: Adenine; Animals; Autophagy; Cecum; Cell Line; Cytokines; Disease Models, Animal; Kidney; Lipopolysa | 2015 |
The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Female; Intestinal Absorption | 2008 |
The roles of cyclic adenosine monophosphate- and cyclic guanosine monophosphate-dependent protein kinase pathways in hydrogen peroxide-induced contractility of microvascular lung pericytes.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cell Survival; Cells, Cultured; | 2003 |
Macrophages are a source of extracellular adenosine deaminase-2 during inflammatory responses.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Adenosine Deaminase; Animals; Cells, Cultured; DNA-Bi | 2004 |
Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats.
Topics: Adenine; Animals; Anticoagulants; Blood Preservation; Citrates; Erythrocyte Transfusion; Glucose; He | 1997 |
cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity in cultured rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Ani | 2001 |