Page last updated: 2024-08-16

timolol and prazosin

timolol has been researched along with prazosin in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199017 (35.42)18.7374
1990's9 (18.75)18.2507
2000's14 (29.17)29.6817
2010's8 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lund-Johansen, P1
Graham, RM; Oates, HF; Stoker, LM; Stokes, GS1
Christoffersen, T; Dajani, L; Dajani, OF; Refsnes, M; Sandnes, D; Thoresen, GH1
Hanem, S; Osnes, JB; Skomedal, T1
Evan, AP; Gattone, VH; Overhage, JM; Severs, WB1
Aass, H; Osnes, JB; Schiander, I; Skomedal, T1
Broadley, KJ; Williamson, KL1
Christiansen, HB; Horgmo, GI; Osnes, JB; Schiander, IG; Skomedal, T1
Goldberg, MR; Hollister, AS; Robertson, D; Tung, CS1
Osnes, JB; Schiander, IG; Skomedal, T1
Castillo, RA; Devoe, LD; Hadi, HA; O'Dell, BE; Searle, N1
Besser, GM; Grossman, A; Holly, JM; Rees, LH; Tsagarakis, S1
Jackson, CV; McGrath, GM; McNeill, JH1
Cerino, D; Kling, P; Lotti, VJ2
Jones, DJ1
Douglas-Jones, AP1
Koponen, A; Lamminsivu, U; Männistö, P; Mäntylä, R; Nykänen, S1
Borthne, K; Hågå, P; Langslet, A; Lindberg, H; Osnes, JB; Skomedal, T1
Okamura, T; Toda, N; Yoshida, K1
Andersen, GO; Enger, M; Osnes, JB; Skomedal, T1
Osnes, JB; Skomedal, T; Viko, H1
Aass, H; Borthne, K; Geiran, O; Osnes, JB; Skomedal, T1
Aubineau, P; Callebert, J; Launay, JM; Reynier-Rebuffel, AM; Seylaz, J1
Berridge, CW; España, RA1
Febbraio, MA; Rolland, J; Starkie, RL1
Febbraio, MA; Hargreaves, M; Howlett, KF; Watt, MJ1
Ayajiki, K; Kimura, T; Okamura, T; Yamamizu, K1
Alsene, KM; Bakshi, VP; Fallace, K1

Reviews

1 review(s) available for timolol and prazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for timolol and prazosin

ArticleYear
Pharmacokinetic interactions of timolol with vasodilating drugs, food and phenobarbitone in healthy human volunteers.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:2

    Topics: Adult; Biological Availability; Dihydralazine; Drug Interactions; Female; Food; Humans; Male; Phenobarbital; Prazosin; Propanolamines; Timolol; Vasodilator Agents

1983
Functional characterization of an ex vivo preparation of atrial myocardium from children with congenital heart defects: sensitivity to tyramine and adrenoceptor antagonists.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:3

    Topics: Adolescent; Atrial Function; Child; Child, Preschool; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Atria; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Myocardial Contraction; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Regression Analysis; Time Factors; Timolol; Tyramine

1994
Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Epinephrine; Exercise; Humans; Hydrocortisone; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Male; Norepinephrine; Prazosin; Rest; T-Lymphocytes; Timolol

2001
Regulation of glucose kinetics during intense exercise in humans: effects of alpha- and beta-adrenergic blockade.
    Metabolism: clinical and experimental, 2003, Volume: 52, Issue:12

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Anaerobic Threshold; Blood Glucose; Epinephrine; Exercise; Exercise Test; Fatty Acids, Nonesterified; Glucose; Hemodynamics; Hormones; Humans; Kinetics; Lactic Acid; Male; Norepinephrine; Oxygen Consumption; Prazosin; Respiratory Mechanics; Timolol

2003

Other Studies

43 other study(ies) available for timolol and prazosin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparative haemodynamic effects of labetalol, timolol, prazosin and the combination of tolamolol and prazosin.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:Suppl 2

    Topics: Adult; Blood Pressure; Drug Combinations; Ethanolamines; Hemodynamics; Humans; Labetalol; Male; Middle Aged; Physical Exertion; Prazosin; Propanolamines; Quinazolines; Rest; Timolol

1979
Haemodynamic effects of prazosin.
    Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 224, Issue:2

    Topics: Animals; Atropine; Blood Cell Count; Blood Pressure; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hemodynamics; Isoproterenol; Pentolinium Tartrate; Prazosin; Quinazolines; Rats; Renin; Timolol

1976
Stimulatory and inhibitory effects of catecholamines on DNA synthesis in primary rat hepatocyte cultures: role of alpha 1- and beta-adrenergic mechanisms.
    Journal of cellular physiology, 1992, Volume: 151, Issue:1

    Topics: Animals; Catecholamines; Cell Division; Cells, Cultured; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epinephrine; G1 Phase; Insulin; Isoproterenol; Liver; Male; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; S Phase; Time Factors; Timolol

1992
Accumulation of potassium and calcium in rat myocardium exposed to alpha-1-adrenoceptor stimulation.
    Pharmacology & toxicology, 1992, Volume: 70, Issue:4

    Topics: Animals; Calcium; Chlorides; Male; Myocardium; Perfusion; Phenylephrine; Potassium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sodium; Timolol

1992
Developing renal innervation in the spontaneously hypertensive rat: evidence for a role of the sympathetic nervous system in renal damage.
    Journal of hypertension, 1990, Volume: 8, Issue:5

    Topics: Animals; Female; Guanethidine; Hypertension; Kidney; Male; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System; Timolol

1990
Properties of the inotropic response in rat papillary muscles to the dihydropyridine "Ca-channel activator" BAY K 8644.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Carbachol; Cyclic AMP; Kinetics; Male; Myocardial Contraction; Papillary Muscles; Prazosin; Rats; Rats, Inbred Strains; Stimulation, Chemical; Timolol

1988
Do both adrenaline and noradrenaline stimulate cardiac alpha-adrenoceptors to induce positive inotropy of rat atria?
    British journal of pharmacology, 1989, Volume: 98, Issue:2

    Topics: Animals; Cocaine; Desipramine; Dibenzylchlorethamine; Epinephrine; Haloperidol; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Norepinephrine; Pindolol; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Timolol

1989
Alpha-adrenergic stimulation contributes to the inotropic effect of noradrenaline.
    Biomedica biochimica acta, 1987, Volume: 46, Issue:8-9

    Topics: Animals; Carbachol; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Papillary Muscles; Prazosin; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Timolol

1987
Both alpha- and beta-adrenoreceptors contribute to the central depressor effect of catecholamines.
    Brain research, 1988, Jul-19, Volume: 456, Issue:1

    Topics: Animals; Blood Pressure; Brain; Catecholamines; Heart Rate; Injections, Intraventricular; Isoquinolines; Male; Medulla Oblongata; Nordefrin; Platelet Aggregation; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tetrahydroisoquinolines; Timolol; Yohimbine

1988
Both alpha and beta adrenoceptor-mediated components contribute to final inotropic response to norepinephrine in rat heart.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Timolol

1988
Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists.
    Obstetrics and gynecology, 1986, Volume: 68, Issue:3 Suppl

    Topics: Adult; alpha-Methyltyrosine; Catecholamines; Drug Therapy, Combination; Female; Fetal Heart; Fetal Monitoring; Fetus; Heart Rate; Humans; Methyltyrosines; Pheochromocytoma; Prazosin; Pregnancy; Pregnancy Complications, Neoplastic; Sympatholytics; Timolol; Tyrosine 3-Monooxygenase

1986
Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro.
    Endocrinology, 1988, Volume: 123, Issue:4

    Topics: Acetylcholine; Animals; Calcium; Corticotropin-Releasing Hormone; Dioxanes; Hypothalamus; Idazoxan; In Vitro Techniques; Kinetics; Male; Moxisylyte; Norepinephrine; Potassium; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Timolol

1988
Alterations in alpha 1-adrenoceptor stimulation of isolated atria from experimental diabetic rats.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:2

    Topics: Animals; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Heart; Heart Atria; In Vitro Techniques; Insulin; Kinetics; Male; Myocardial Contraction; Myocardium; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Timolol

1986
High and low (Gpp(NH)p-sensitive) affinity sites for beta 2-adrenergic blockers as antagonists of isoproterenol in the field-stimulated rat vas deferens.
    European journal of pharmacology, 1982, Oct-22, Volume: 84, Issue:3-4

    Topics: Adrenergic beta-Antagonists; Albuterol; Animals; Electric Stimulation; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Isoproterenol; Male; Muscle, Smooth; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Timolol; Vas Deferens

1982
Depolarizing agent-induced cyclic AMP accumulation in isolated rat spinal cord.
    Life sciences, 1982, Aug-02, Volume: 31, Issue:5

    Topics: Animals; Cyclic AMP; Guinea Pigs; Male; Ouabain; Potassium; Prazosin; Rats; Rats, Inbred Strains; Spinal Cord; Time Factors; Timolol; Veratridine; Veratrine

1982
Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment.
    Journal of autonomic pharmacology, 1982, Volume: 2, Issue:3

    Topics: Animals; Isoproterenol; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reserpine; Timolol; Vas Deferens; Yohimbine

1982
Timolol/bendrofluazide combination ('Prestim') in the treatment of poorly controlled hypertensive patients in general practice.
    Pharmatherapeutica, 1984, Volume: 3, Issue:9

    Topics: Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Drug Combinations; Family Practice; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Pulse; Timolol

1984
Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Dinoprost; Dogs; Electric Stimulation; Female; Hexamethonium; Indomethacin; Macaca; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Dehydrogenase; Nerve Fibers; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prazosin; Tetrodotoxin; Timolol; Veins

1995
Concentration-response relationship of alpha 1-adrenoceptor-stimulated increase of 86Rb+ efflux in rat heart.
    Pharmacology & toxicology, 1996, Volume: 79, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Dose-Response Relationship, Drug; Heart; Isotope Labeling; Male; Myocardium; Phenylephrine; Potassium; Prazosin; Rats; Rats, Wistar; Rubidium; Timolol

1996
Alpha(1)- and beta-adrenoceptor-mediated increase in 86Rb(+)-uptake in isolated cardiomyocytes from adult rat heart: evidence for interaction between the two receptor systems.
    Pharmacology & toxicology, 1996, Volume: 79, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic Antagonists; Animals; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Heart; Myocardium; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Rubidium Radioisotopes; Timolol

1996
Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Adrenergic Antagonists; Heart; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Timolol

1997
NE inhibits cerebrovascular mast cell exocytosis induced by cholinergic and peptidergic agonists.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Adrenergic Antagonists; Animals; Atenolol; Carbachol; Cerebral Arteries; Cerebrovascular Circulation; Exocytosis; In Vitro Techniques; Kinetics; Male; Mast Cells; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rabbits; Serotonin; Timolol

1997
Synergistic sedative effects of noradrenergic alpha(1)- and beta-receptor blockade on forebrain electroencephalographic and behavioral indices.
    Neuroscience, 2000, Volume: 99, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arousal; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Electromyography; Locus Coeruleus; Male; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta-1; Timolol

2000
Mechanisms underlying mechanical responses to Ephedra herb of isolated rabbit urinary bladder and urethra, a possible stress urinary incontinence therapeutic.
    Journal of pharmacological sciences, 2008, Volume: 107, Issue:2

    Topics: Animals; Ephedra; Ephedrine; Female; In Vitro Techniques; Male; Muscle Contraction; Phytotherapy; Plant Extracts; Prazosin; Rabbits; Timolol; Urethra; Urinary Bladder; Urinary Incontinence, Stress

2008
Ventral striatal noradrenergic mechanisms contribute to sensorimotor gating deficits induced by amphetamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:12

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Amphetamine; Animals; Basal Ganglia; Drug Interactions; Inhibition, Psychological; Male; Microinjections; Motor Activity; Nucleus Accumbens; Prazosin; Rats; Rats, Sprague-Dawley; Reflex, Startle; Sensory Gating; Timolol

2010