Compounds > tak 779
Page last updated: 2024-09-05

tak 779 and plerixafor

tak 779 has been researched along with plerixafor in 15 studies

Compound Research Comparison

Studies
(tak 779)		Trials
(tak 779)		Recent Studies (post-2010)
(tak 779)		Studies
(plerixafor)		Trials
(plerixafor)		Recent Studies (post-2010) (plerixafor)
1181351,312113930

Protein Interaction Comparison

ProteinTaxonomytak 779 (IC50)plerixafor (IC50)
C-X-C chemokine receptor type 4Rattus norvegicus (Norway rat)0.108
C-C chemokine receptor type 2Homo sapiens (human)0.0001
C-X-C chemokine receptor type 4Homo sapiens (human)0.3717

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (60.00)29.6817
2010's6 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baba, M; Miyake, H; Okamoto, M; Takashima, K; Wang, X1
Parmentier, M; Sohy, D; Springael, JY1
Chen, CH; Ho, P; Huang, L; Lai, W; Li, Z; Montefiori, D1
Ballweber, L; Fialkow, M; Hladik, F; Kreger, A; Lentz, G; McElrath, MJ; Robinson, B; Sakchalathorn, P; Terker, A1
Horuk, R; Pease, J1
Bond, VC; Cox, BD; Huang, MB; Krystal, M; Lee, S; Li, Z; Liotta, DC; Prosser, AR; Snyder, JP; Sun, Y; Wilson, LJ1
Gettie, A; Lal, RB; Lou, B; Marx, PA; Moore, JP; Zhang, Y1
Gordon, CA; Moore, JP; Spenlehauer, C; Trkola, A1
Maddon, PJ; Olson, WC1
Alespeiti, G; Debnath, AK; He, Y; Zhao, Q1
Armand-Ugón, M; Clotet, B; Esté, JA; Moncunill, G; Pauls, E1
de Nadai, P; Guillabert, A; Javitch, JA; Parmentier, M; Sohy, D; Springael, JY; Urizar, E; Yano, H1
Abergel, J; Branch, A; Chang, TL; Ding, J; Garber, J; Gutierrez, J; Hubner, W; Klepper, A; Mosoian, A; Rapista, A; Schiano, T; Walewski, J1
Chan, LW; Pei, XM; Sin, TK; Siu, PM; Wong, CS; Yip, SP; Yu, AP; Yung, BY1
Arakelyan, A; Chernomordik, LV; Margolis, LB; Marin, M; Melikov, K; Melikyan, GB; Villasmil, R; Zaitsev, E; Zaitseva, E1

Reviews

1 review(s) available for tak 779 and plerixafor

ArticleYear
Resistance to HIV-1 entry inhibitors.
    Current drug targets. Infectious disorders, 2003, Volume: 3, Issue:4

    Topics: Amides; Anti-HIV Agents; Benzylamines; CD4 Immunoadhesins; Cyclams; Drug Resistance, Viral; Enfuvirtide; Heterocyclic Compounds; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Peptide Fragments; Piperazines; Quaternary Ammonium Compounds

2003

Other Studies

14 other study(ies) available for tak 779 and plerixafor

ArticleYear
Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2

    Topics: Amino Acid Sequence; Anti-HIV Agents; CCR5 Receptor Antagonists; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Imidazoles; Leukocytes, Mononuclear; Molecular Sequence Data; Sulfoxides; Virus Replication

2007
Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers.
    The Journal of biological chemistry, 2007, Oct-12, Volume: 282, Issue:41

    Topics: Allosteric Site; Animals; Binding, Competitive; Calcium; Chemotaxis; CHO Cells; Cricetinae; Cricetulus; Dimerization; Humans; Inhibitory Concentration 50; Kinetics; Protein Binding; Receptors, CCR2; Receptors, CXCR4; T-Lymphocytes

2007
Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:1

    Topics: Animals; Anti-HIV Agents; Betulinic Acid; Cell Line; Chlorocebus aethiops; COS Cells; Drug Resistance, Viral; HIV Envelope Protein gp120; HIV Fusion Inhibitors; HIV-1; Humans; Membrane Fusion; Microbial Sensitivity Tests; Models, Molecular; Pentacyclic Triterpenes; Peptide Fragments; Triterpenes

2008
Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Adult; Anti-HIV Agents; Benzothiepins; Cells, Cultured; Enfuvirtide; Female; Flow Cytometry; Genotype; HIV Envelope Protein gp41; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; In Vitro Techniques; Microscopy, Confocal; Peptide Fragments; Polymerase Chain Reaction; Virus Integration

2010
Chemokine receptor antagonists.
    Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22

    Topics: Animals; Autoimmune Diseases; Humans; Receptors, Chemokine

2012
Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.
    ACS medicinal chemistry letters, 2015, Jul-09, Volume: 6, Issue:7

    Topics:

2015
Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cells.
    Journal of virology, 2000, Volume: 74, Issue:15

    Topics: Amides; Animals; Anti-HIV Agents; Benzylamines; CD4 Antigens; Cell Line; Chemokine CCL5; Cyclams; Heterocyclic Compounds; HIV-1; HIV-2; Humans; Leukocytes, Mononuclear; Lymphocytes; Macaca; Quaternary Ammonium Compounds; Receptors, CCR2; Receptors, CCR3; Receptors, CCR5; Receptors, Chemokine; Receptors, HIV; Receptors, Virus; Simian Immunodeficiency Virus; Transfection; Tumor Cells, Cultured; Virus Replication

2000
A luciferase-reporter gene-expressing T-cell line facilitates neutralization and drug-sensitivity assays that use either R5 or X4 strains of human immunodeficiency virus type 1.
    Virology, 2001, Feb-15, Volume: 280, Issue:2

    Topics: Amides; Anti-HIV Agents; Antibodies, Viral; Benzylamines; CCR5 Receptor Antagonists; Cell Line; Cell Line, Transformed; Cyclams; Drug Evaluation, Preclinical; Gene Expression; Genes, Reporter; Heterocyclic Compounds; HIV Core Protein p24; HIV-1; Humans; Luciferases; Neutralization Tests; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; T-Lymphocytes

2001
A novel assay to identify entry inhibitors that block binding of HIV-1 gp120 to CCR5.
    Virology, 2004, Sep-01, Volume: 326, Issue:2

    Topics: Amides; Animals; Anti-HIV Agents; Benzylamines; CCR5 Receptor Antagonists; CD4 Antigens; Cell Line; Cyclams; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Heterocyclic Compounds; HIV Envelope Protein gp120; HIV Infections; HIV-1; Protein Conformation; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; Virulence; Virus Replication

2004
HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro.
    AIDS (London, England), 2008, Jan-02, Volume: 22, Issue:1

    Topics: Amides; Amino Acid Sequence; Benzylamines; CCR5 Receptor Antagonists; Cell Line, Transformed; Cell Line, Tumor; Cells, Cultured; Cyclams; Evolution, Molecular; Genetic Variation; Heterocyclic Compounds; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Molecular Sequence Data; Peptide Fragments; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; Reverse Transcriptase Inhibitors; Sequence Alignment; Time Factors; Virus Attachment

2008
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.
    The Journal of biological chemistry, 2009, Nov-06, Volume: 284, Issue:45

    Topics: Amides; Animals; Benzylamines; CCR5 Receptor Antagonists; Cell Line; Cells, Cultured; Cyclams; Heterocyclic Compounds; Humans; Mice; Mice, Inbred BALB C; Monocytes; Protein Multimerization; Quaternary Ammonium Compounds; Receptors, CCR2; Receptors, CCR5; Receptors, CXCR4; T-Lymphocytes

2009
Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 53, Issue:3

    Topics: Amides; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Ascitic Fluid; Benzylamines; Cells, Cultured; Cyclams; Gene Expression Profiling; Heterocyclic Compounds; HIV Fusion Inhibitors; HIV-1; Humans; Macrophages, Peritoneal; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; Receptors, HIV; Virus Internalization

2010
[D-Lys3]-GHRP-6 exhibits pro-autophagic effects on skeletal muscle.
    Molecular and cellular endocrinology, 2015, Feb-05, Volume: 401

    Topics: Amides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzylamines; Cyclams; Doxorubicin; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Muscle Cells; Muscle, Skeletal; Oligopeptides; Piperidines; Quaternary Ammonium Compounds; Quinazolinones; Receptors, CXCR4; Signal Transduction

2015
Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.
    Cell host & microbe, 2017, Jul-12, Volume: 22, Issue:1

    Topics: Amides; Anoctamins; Antibodies, Monoclonal; Benzylamines; Calcium; CD4 Antigens; Cell Line; Cell Membrane; Cyclams; HEK293 Cells; HeLa Cells; Heterocyclic Compounds; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Membrane Fusion; Phosphatidylserines; Phospholipid Transfer Proteins; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; Signal Transduction; Viral Envelope Proteins; Virus Activation; Virus Attachment; Virus Internalization; Virus Replication

2017