quinaprilat and quinapril
quinaprilat has been researched along with quinapril in 35 studies
Compound Research Comparison
| Studies (quinaprilat) | Trials (quinaprilat) | Recent Studies (post-2010) (quinaprilat) | Studies (quinapril) | Trials (quinapril) | Recent Studies (post-2010) (quinapril) |
|---|---|---|---|---|---|
| 92 | 23 | 4 | 652 | 220 | 47 |
Protein Interaction Comparison
| Protein | Taxonomy | quinaprilat (IC50) | quinapril (IC50) |
|---|---|---|---|
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.0083 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.11 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 0.0083 |
Research
Studies (35)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.43) | 18.7374 |
| 1990's | 18 (51.43) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Codding, PW; Hausin, RJ | 1 |
| Cohen, D; Essenburg, AD; Kaplan, HR; Roark, WH; Tinney, FJ | 1 |
| Blankley, CJ; Cohen, DM; Essenburg, AD; Fleming, RW; Hinkley, JM; Hoefle, ML; Holmes, A; Klutchko, S; Nordin, I; Werner, AE | 1 |
| Elliott, HL; Macdonald, NJ; Meredith, PA; Reid, JL | 1 |
| Goto, N; Ikegami, K; Kamata, T | 1 |
| Abraham, PA; Halstenson, CE; Horvath, AM; Olson, SC; Opsahl, JA; Posvar, EL; Rachael, K | 1 |
| Bailey, RR; Begg, EJ; Frank, GJ; Lynn, KL; Olson, SC; Robson, RA | 1 |
| Blum, RA; Horvath, AM; Kohli, RK; Olson, SC; Posvar, EL; Sedman, AJ | 1 |
| Horvath, AM; Olson, SC; Posvar, EL; Starmann, B; Swartz, RD | 1 |
| Caillé, G; Colburn, WA; Ferry, JJ; Frank, GJ; Horvath, AM; Lacasse, Y; Olson, SC; Pilon, D | 1 |
| Colburn, WA; Horvath, AM; Michniewicz, BM; Olson, SC; Sedman, AJ; Welling, PG | 1 |
| Cetnarowski, AB; Ferry, JJ; Horvath, AM; Sedman, AJ; Thomas, RW | 1 |
| Kugler, AR; Olson, SC; Smith, DE | 3 |
| Bammert-Adams, JA; Begg, EJ; Ikram, H; Olson, SC; Posvar, EL; Reece, PA; Richards, AM; Robson, RA; Sedman, AJ | 1 |
| Fritschka, E; Wolter, K | 1 |
| Breslin, E; Jahnchen, E; Neub, M; Posvar, E; Trenk, D | 1 |
| Kugler, AR; Schnermann, JB; Smith, DE | 1 |
| Canter, D; Goldstein, R; McCormick, L; Whelton, A; Wombolt, D | 1 |
| Abiko, Y; Hara, A; Hashizume, H; Ma, H; Yazawa, K | 1 |
| Akarawut, W; Lin, CJ; Smith, DE | 1 |
| Alonso, RM; Blanco, A; Jiménez, RM; Prieto, JA | 1 |
| Begg, EJ; Gardiner, SJ; Hudson, LJ; Olson, SC; Posvar, EL; Reece, PA; Robson, RA; Sedman, AJ | 1 |
| Alonso, RM; Jiménez, RM; Prieto, JA | 1 |
| Abbara, Ch; Aymard, G; Diquet, B; Hinh, S | 1 |
| Awaya, T; Hara, A; Hayase, N; Matsubara, K; Satomi, M; Shimizu, K | 1 |
| Hiromi, Y; Kato, K; Kawahara, H; Muraoka, I; Nabeshima, T; Seno, H; Takasu, R; Yamada, S | 1 |
| Jengjareon, A; Kumsorn, B; Nasangiam, N; Rojanasthien, N; Roongapinun, S | 1 |
| Gomes, NA; Joshi, SS; Kamat, SS; Parekh, SA; Pudage, A; Vaidya, VV | 1 |
| Dasandi, B; Shah, S | 1 |
| Albu, F; Cristea, E; David, V; Medvedovici, A; Sora, I; Udrescu, S | 1 |
| Barlow, BM; Breuhaus, BA; Davis, JL; Kruger, K; LaFevers, DH; Schirmer, JM | 1 |
| Backman, JT; Holmberg, MT; Launiainen, T; Neuvonen, PJ; Niemi, M; Tarkiainen, EK; Tornio, A | 1 |
| Cao, Y; Deng, B; Sun, S; Wang, H; Wei, Y | 1 |
Trials
9 trial(s) available for quinaprilat and quinapril
| Article | Year |
|---|---|
Dose responses and pharmacokinetics for the angiotensin converting enzyme inhibitor quinapril.
Topics: Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Isoquinolines; Male; Peptidyl-Dipeptidase A; Quinapril; Renin; Tetrahydroisoquinolines | 1992 |
A pharmacodynamic and pharmacokinetic comparison of intravenous quinaprilat and oral quinapril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Injections, Intravenous; Isoquinolines; Male; Peptidyl-Dipeptidase A; Placebos; Prodrugs; Quinapril; Tetrahydroisoquinolines | 1996 |
Assessing the clinical need for short-term conversion from oral to parenteral angiotensin converting enzyme inhibitor therapy in hypertensive patients. A quinapril to quinaprilat placebo-controlled model.
Topics: Administration, Oral; Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure Monitors; Double-Blind Method; Female; Humans; Hypertension; Infusions, Intravenous; Isoquinolines; Male; Middle Aged; Prodrugs; Quinapril; Tetrahydroisoquinolines | 1997 |
Quinapril and its metabolite quinaprilat in human milk.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Breast Feeding; Female; Humans; Isoquinolines; Middle Aged; Milk, Human; Quinapril; Tetrahydroisoquinolines | 2001 |
Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis.
Topics: Administration, Oral; Adult; Angiotensin-Converting Enzyme Inhibitors; Chromatography, High Pressure Liquid; Half-Life; Humans; Hypertension; Indoles; Male; Metabolic Clearance Rate; Middle Aged; Perindopril; Quinapril; Renal Dialysis; Renal Insufficiency; Tetrahydroisoquinolines | 2003 |
Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers.
Topics: Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Cross-Over Studies; Healthy Volunteers; Humans; Linear Models; Male; Quinapril; Tablets; Tetrahydroisoquinolines; Thailand; Therapeutic Equivalency | 2008 |
LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation.
Topics: Adult; Biological Assay; Calibration; Carbazoles; Carvedilol; Chromatography, Liquid; Cross-Over Studies; Drug Evaluation; Female; Humans; Male; Propanolamines; Quinapril; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tetrahydroisoquinolines; Therapeutic Equivalency; Young Adult | 2009 |
Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses.
Topics: Administration, Intravenous; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Area Under Curve; Gene Expression Regulation, Enzymologic; Half-Life; Horses; Peptidyl-Dipeptidase A; Quinapril; Renin; Tetrahydroisoquinolines | 2014 |
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Carboxylic Ester Hydrolases; Cross-Over Studies; Enalapril; Enalaprilat; Female; Genotype; Healthy Volunteers; Heart Rate; Humans; Male; Polymorphism, Single Nucleotide; Quinapril; Tetrahydroisoquinolines; Young Adult | 2015 |
Other Studies
26 other study(ies) available for quinaprilat and quinapril
| Article | Year |
|---|---|
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Crystallography; Isoquinolines; Pyridones; Quinapril; Tetrahydroisoquinolines | 1991 |
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chemical Phenomena; Chemistry; Dipeptides; Enalapril; Guinea Pigs; Hypertension, Renal; Indoles; Isoquinolines; Quinapril; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines | 1985 |
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Male; Molecular Conformation; Quinapril; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydroisoquinolines | 1986 |
Trace analysis of quinapril and its active metabolite, quinaprilat, in human plasma and urine by gas chromatography-negative-ion chemical ionization mass spectrometry.
Topics: Angiotensin-Converting Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Ions; Isoquinolines; Quinapril; Tetrahydroisoquinolines | 1992 |
The pharmacokinetics of quinapril and its active metabolite, quinaprilat, in patients with various degrees of renal function.
Topics: Administration, Oral; Adolescent; Adult; Aged; Drug Administration Schedule; Half-Life; Humans; Isoquinolines; Kidney Diseases; Metabolic Clearance Rate; Middle Aged; Quinapril; Tetrahydroisoquinolines | 1992 |
The pharmacokinetics and pharmacodynamics of quinapril and quinaprilat in renal impairment.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Female; Glomerular Filtration Rate; Heart Rate; Humans; Isoquinolines; Male; Middle Aged; Quinapril; Random Allocation; Renin; Statistics as Topic; Tetrahydroisoquinolines | 1990 |
Pharmacokinetics of quinapril and its active metabolite, quinaprilat, in patients on chronic hemodialysis.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Female; Half-Life; Humans; Isoquinolines; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Quinapril; Renal Dialysis; Tetrahydroisoquinolines; Time Factors | 1990 |
Pharmacokinetics of quinapril and its active metabolite quinaprilat during continuous ambulatory peritoneal dialysis.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Female; Humans; Isoquinolines; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Quinapril; Tetrahydroisoquinolines | 1990 |
Multiple-dose propranolol administration does not influence the single dose pharmacokinetics of quinapril and its active metabolite (quinaprilat).
Topics: Adult; Drug Interactions; Humans; Isoquinolines; Male; Propranolol; Quinapril; Tetrahydroisoquinolines | 1990 |
The clinical pharmacokinetics of quinapril.
Topics: Absorption; Adult; Angiotensin-Converting Enzyme Inhibitors; Half-Life; Humans; Isoquinolines; Male; Quinapril; Random Allocation; Tetrahydroisoquinolines | 1989 |
Multiple-dose cimetidine administration does not influence the single-dose pharmacokinetics of quinapril and its active metabolite (CI-928).
Topics: Adult; Antihypertensive Agents; Cimetidine; Drug Interactions; Female; Humans; Isoquinolines; Male; Quinapril; Tetrahydroisoquinolines | 1988 |
Determination of quinapril and quinaprilat by high-performance liquid chromatography with radiochemical detection, coupled to liquid scintillation counting spectrometry.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Isoquinolines; Pilot Projects; Quinapril; Rats; Reference Standards; Reproducibility of Results; Scintillation Counting; Tetrahydroisoquinolines; Tritium | 1995 |
The pharmacokinetics of quinapril and quinaprilat in patients with congestive heart failure.
Topics: Administration, Oral; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Drug Administration Schedule; Female; Half-Life; Heart Failure; Humans; Isoquinolines; Kidney Function Tests; Male; Middle Aged; Quinapril; Tetrahydroisoquinolines | 1994 |
Pharmacokinetics and pharmacodynamics of quinaprilat after low dose quinapril in patients with terminal renal failure.
Topics: Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Female; Humans; Isoquinolines; Kidney Failure, Chronic; Male; Middle Aged; Peptidyl-Dipeptidase A; Peritoneal Dialysis, Continuous Ambulatory; Quinapril; Renal Dialysis; Tetrahydroisoquinolines | 1993 |
Reabsorption and metabolism of quinapril and quinaprilat in rat kidney: in vivo micropuncture studies.
Topics: Absorption; Angiotensin-Converting Enzyme Inhibitors; Animals; Isoquinolines; Kidney Tubules; Male; Microinjections; Nephrons; Prodrugs; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Urodynamics | 1995 |
Disposition of quinapril and quinaprilat in the isolated perfused rat kidney.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; In Vitro Techniques; Inulin; Isoquinolines; Kidney; Male; Perfusion; Prodrugs; Protein Binding; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 1995 |
Tubular transport mechanisms of quinapril and quinaprilat in the isolated perfused rat kidney: effect of organic anions and cations.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Dose-Response Relationship, Drug; Isoquinolines; Kidney Tubules; Male; Perfusion; Protein Binding; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 1996 |
Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Calcium; Cell Size; Creatine Kinase; Enalapril; Enalaprilat; Isoquinolines; Lysophosphatidylcholines; Male; Micelles; Myocardium; Propranolol; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Vasodilator Agents | 1999 |
Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Binding, Competitive; Captopril; Carrier Proteins; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enalapril; Fosinopril; Isoquinolines; Kidney; Kinetics; Lipid Metabolism; Lipids; Lisinopril; Male; Microvilli; Peptide Transporter 1; Quinapril; Rabbits; Ramipril; Symporters; Tetrahydroisoquinolines | 1999 |
Solid-phase extraction and high-performance liquid chromatography applied to the determination of quinapril and its metabolite quinaprilat in urine.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Isoquinolines; Quinapril; Reproducibility of Results; Tetrahydroisoquinolines | 2001 |
Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Calibration; Electrophoresis, Capillary; Female; Humans; Isoquinolines; Male; Middle Aged; Pharmaceutical Preparations; Quinapril; Reference Standards; Sensitivity and Specificity; Tetrahydroisoquinolines | 2002 |
Simultaneous determination of quinapril and its active metabolite quinaprilat in human plasma using high-performance liquid chromatography with ultraviolet detection.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calibration; Chromatography, High Pressure Liquid; Humans; Isoquinolines; Quinapril; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tetrahydroisoquinolines; Therapeutic Equivalency | 2002 |
Protective effects of quinaprilat and trandolaprilat, active metabolites of quinapril and trandolapril, on hemolysis induced by lysophosphatidylcholine in human erythrocytes.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Hemolysis; Humans; Hypotonic Solutions; In Vitro Techniques; Indoles; Lysophosphatidylcholines; Micelles; Propranolol; Quinapril; Sodium Chloride; Tetrahydroisoquinolines | 2003 |
Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrochlorothiazide; Quinapril; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tetrahydroisoquinolines; Therapeutic Equivalency | 2008 |
Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry.
Topics: Chromatography, Liquid; Humans; Lisinopril; Quinapril; Reference Standards; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tetrahydroisoquinolines; Time Factors | 2009 |
A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma.
Topics: 2,2'-Dipyridyl; Antihypertensive Agents; Biotransformation; Buffers; Calibration; Coordination Complexes; Electrochemical Techniques; Electrodes; Electrophoresis, Capillary; Humans; Limit of Detection; Luminescent Measurements; Metal Nanoparticles; Povidone; Quinapril; Silicon Dioxide; Tetrahydroisoquinolines; Zinc Oxide | 2018 |