Page last updated: 2024-08-18

pyrroles and sjg 136

pyrroles has been researched along with sjg 136 in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's21 (70.00)29.6817
2010's9 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adams, LJ; Brooks, NA; Gregson, SJ; Hartley, JA; Howard, PW; Jenkins, TC; Kelland, LR; Thurston, DE1
Cooper, P; Howard, PW; Jenkins, TC; Loadman, PM; Shnyder, S; Taylor, JP; Thurston, DE; Wilkinson, GP1
Alley, MC; Brooks, N; Clingen, PH; Gregson, SJ; Hartley, JA; Hochhauser, D; Hollingshead, MG; Howard, PW; Kelland, LR; McHugh, PJ; Pedley, RB; Sausville, EA; Schultz, R; Schweikart, KM; Spanswick, VJ; Thurston, DE; Tomaszewski, JE1
Alley, MC; Gregson, SJ; Hartley, JA; Hollingshead, MG; Howard, PW; Pacula-Cox, CM; Sausville, EA; Thurston, DE; Waud, WR1
Delavault, P; Fegan, CD; Hambly, RM; Pepper, CJ; Thurston, DE1
Kamal, A; Laxman, E; Murthy, YL; Reddy, DR; Reddy, PS1
Ellis, T; Hartley, JA; Jenkins, TC; Martin, C; McGurk, CJ; Thurston, DE; Waring, MJ1
Clingen, PH; De Silva, IU; Ghadessy, FJ; Hartley, JA; McHugh, PJ; Thurston, DE; Tilby, MJ1
Cheung, A; He, J; Liu, P; Struble, E; Thurston, DE; Wang, E; Yang, C1
Guichard, SM; Jodrell, DI; Macpherson, JS; Thurston, DE1
Veryard, C1
Ames, MM; Buhrow, SA; Covey, JM; Grossi, IM; Jia, L; Kobs, DJ; McGovern, RM; Reid, JM1
Arnould, S; Guichard, SM; Hartley, JA; Jodrell, DI; Macpherson, JS; Spanswick, VJ; Thurston, DE1
Bibby, MC; Cooper, PA; Shnyder, SD; Suggitt, M1
Aird, RE; Guichard, SM; Jodrell, DI; Macpherson, JS; Thomson, M; Thurston, DE1
Delavault, P; Fegan, C; Hartley, JA; Lowe, H; Pepper, C; Thurieau, C; Thurston, DE1
Hachey, DL; Lee, W; Puzanov, I; Rothenberg, ML; Wade Calcutt, M1
Griffiths, WJ; Howard, PW; Narayanaswamy, M; Thurston, DE1
Begent, RH; Clingen, PH; Cobb, M; Gumbrell, L; Hartley, JA; Hochhauser, D; Jodrell, D; Loadman, P; Meyer, T; Spanswick, VJ; Wu, J1
Azzoli, CG; Calcutt, MW; Janjigian, YY; Kris, MG; Krug, LM; Lee, W; Miller, VA; Rizvi, NA; Senturk, E1
James, CH; Narayanaswamy, M; Rahman, KM; Thompson, AS; Thurston, DE1
Chen, Z; Coffils, MJ; Cooper, N; Fang, M; Gregson, SJ; Hartley, JA; Howard, PW; Klee, S; Masterson, LA; Thurston, DE; Tiberghien, AC1
Ames, MM; Buhrow, SA; Hartley, JA; Jia, L; Kuffel, MJ; Reid, JM; Spanswick, VJ; Thurston, DE; Tomaszewski, JE1
Berlin, JD; Calcutt, MW; Chen, AP; Hachey, DL; Hartley, JA; Lee, W; Liao, CY; Puzanov, I; Rothenberg, ML; Spanswick, VJ; Vermeulen, WL1
James, CH; Rahman, KM; Thurston, DE1
Hartley, JA1
Hartley, JA; Hochhauser, D1
Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J1
Baines, SJ; Hartley, JA; Mellinas-Gomez, M; Paredes-Moscosso, SR; Pedley, RB; Robson, M; Spanswick, VJ; Stell, A; Thurston, DE1
Buzon, B; Grainger, R; Huang, S; Junop, MS; Rzadki, C1

Reviews

2 review(s) available for pyrroles and sjg 136

ArticleYear
The development of pyrrolobenzodiazepines as antitumour agents.
    Expert opinion on investigational drugs, 2011, Volume: 20, Issue:6

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; DNA Damage; Drug Delivery Systems; Drug Design; Humans; Neoplasms; Pyrroles; Structure-Activity Relationship

2011
Small molecule drugs - optimizing DNA damaging agent-based therapeutics.
    Current opinion in pharmacology, 2012, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Benzodiazepinones; Dioxoles; DNA; DNA Damage; Humans; Neoplasms; Nitrogen Mustard Compounds; Pyrroles; Tetrahydroisoquinolines; Trabectedin

2012

Trials

3 trial(s) available for pyrroles and sjg 136

ArticleYear
Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Mar-15, Volume: 15, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Benzodiazepinones; DNA; Histones; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles

2009
A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:5

    Topics: Aged; Antineoplastic Agents; Benzodiazepinones; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Ovarian Neoplasms; Pyrroles; Urinary Bladder Neoplasms

2010
Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jun-01, Volume: 17, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Benzodiazepinones; Dexamethasone; Dyspnea; Edema; Fatigue; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles

2011

Other Studies

25 other study(ies) available for pyrroles and sjg 136

ArticleYear
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
    Journal of medicinal chemistry, 2001, Mar-01, Volume: 44, Issue:5

    Topics: Antineoplastic Agents; Benzodiazepinones; Cisplatin; Cross-Linking Reagents; DNA; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Electrophoresis, Agar Gel; Heating; Humans; Models, Molecular; Protein Denaturation; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
    Investigational new drugs, 2004, Volume: 22, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Blood Proteins; Cell Line, Tumor; Chromatography, Liquid; Cross-Linking Reagents; Dimerization; DNA; Drug Screening Assays, Antitumor; Drug Stability; Female; In Vitro Techniques; Mass Spectrometry; Mice; Mice, Nude; Protein Binding; Pyrroles

2004
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
    Cancer research, 2004, Sep-15, Volume: 64, Issue:18

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Comet Assay; Cross-Linking Reagents; DNA; Dogs; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Pyrroles; Xenograft Model Antitumor Assays

2004
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
    Cancer research, 2004, Sep-15, Volume: 64, Issue:18

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Mice; Mice, Nude; Pyrroles; Rats; Rats, Nude; Urea; Xenograft Model Antitumor Assays

2004
The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
    Cancer research, 2004, Sep-15, Volume: 64, Issue:18

    Topics: Apoptosis; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Case-Control Studies; Caspase 3; Caspases; Cross-Linking Reagents; DNA Damage; DNA Repair; Enzyme Activation; Humans; K562 Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrroles; T-Lymphocytes; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vidarabine

2004
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
    Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22

    Topics: Benzodiazepines; Benzodiazepinones; Binding Sites; DNA; Fluorine Compounds; Molecular Conformation; Pyrroles; Structure-Activity Relationship

2004
Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
    Biochemistry, 2005, Mar-22, Volume: 44, Issue:11

    Topics: Bacterial Proteins; Bacteriophage T7; Base Sequence; Benzodiazepinones; Capsid Proteins; Cross-Linking Reagents; Deoxyribonuclease I; Deoxyribonucleases, Type II Site-Specific; DNA Footprinting; DNA, Single-Stranded; DNA, Viral; Enzyme Inhibitors; Molecular Sequence Data; Nucleic Acid Conformation; Polymerase Chain Reaction; Pyrroles; RNA-Binding Proteins; Sequence Analysis, DNA; Temperature; Transcription, Genetic

2005
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.
    Nucleic acids research, 2005, Volume: 33, Issue:10

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Melphalan; Pyrroles; Recombination, Genetic

2005
Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501).
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Aug-05, Volume: 822, Issue:1-2

    Topics: Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Drug Stability; Imines; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrroles

2005
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:12

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepinones; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Humans; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Heterologous; Verapamil

2005
AACR-NCI-EORTC--17th symposium: Molecular targets and cancer therapeutics. 14-18th November 2005, Philadelphia, PA, USA.
    IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:1

    Topics: Angiopoietin-2; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzodiazepinones; Clinical Trials, Phase I as Topic; ErbB Receptors; Humans; Neoplasms; Ornithine; Pterins; Pyrroles; Receptor, EphA2; Societies, Scientific

2006
LC-MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501).
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Aug-07, Volume: 840, Issue:1

    Topics: Animals; Benzodiazepinones; Chromatography, High Pressure Liquid; Dogs; Humans; Mass Spectrometry; Mice; Protein Binding; Pyrroles; Rats; Reference Standards

2006
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:6

    Topics: Benzodiazepinones; Cell Survival; Checkpoint Kinase 1; Cross-Linking Reagents; DNA; DNA Damage; HCT116 Cells; Humans; Phosphorylation; Protein Kinases; Pyrroles; S Phase; Signal Transduction; Time Factors

2006
The hollow fibre model--facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare.
    International journal of oncology, 2006, Volume: 29, Issue:6

    Topics: Aminoacridines; Animal Welfare; Animals; Benzodiazepinones; Cell Growth Processes; Comet Assay; Drug Screening Assays, Antitumor; Female; HL-60 Cells; HT29 Cells; Humans; Mice; Microscopy, Fluorescence; Mitomycin; Neoplasm Transplantation; Pyrroles; Transplantation, Heterologous

2006
ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136.
    The pharmacogenomics journal, 2008, Volume: 8, Issue:4

    Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Benzodiazepinones; Cell Line, Transformed; Cell Line, Tumor; Gene Expression Regulation; Humans; Mice; Polymorphism, Genetic; Pyrroles

2008
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
    British journal of cancer, 2007, Jul-16, Volume: 97, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cross-Linking Reagents; DNA; DNA Repair; DNA-Binding Proteins; Drug Synergism; Endonucleases; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pyrroles; Transcription, Genetic; Tumor Cells, Cultured; Vidarabine

2007
Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study.
    Journal of mass spectrometry : JMS, 2008, Volume: 43, Issue:1

    Topics: Antineoplastic Agents; Benzodiazepinones; Chromatography, High Pressure Liquid; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Humans; Oxidation-Reduction; Pyrroles; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2008
An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences.
    Analytical biochemistry, 2008, Mar-01, Volume: 374, Issue:1

    Topics: Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; Mass Spectrometry; Oligodeoxyribonucleotides; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2008
The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
    Journal of the American Chemical Society, 2009, Sep-30, Volume: 131, Issue:38

    Topics: Base Sequence; Benzodiazepinones; Cross-Linking Reagents; Dimerization; DNA Adducts; Nucleic Acid Conformation; Pyrroles

2009
Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
    Bioorganic & medicinal chemistry letters, 2009, Nov-15, Volume: 19, Issue:22

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Computer Simulation; DNA; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epoxy Compounds; Humans; Models, Molecular; Prodrugs; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship

2009
Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:3

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzodiazepinones; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Comet Assay; DNA; DNA Damage; Half-Life; In Vitro Techniques; Indicators and Reagents; Male; Mass Spectrometry; Microsomes, Liver; Monocytes; Pharmaceutical Solutions; Pyrroles; Rats; Rats, Inbred F344

2011
Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
    Nucleic acids research, 2011, Volume: 39, Issue:13

    Topics: Base Sequence; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dimerization; DNA; Mass Spectrometry; Models, Molecular; Oligonucleotides; Pyrroles

2011
γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Feb-01, Volume: 19, Issue:3

    Topics: Benzodiazepinones; Comet Assay; DNA Damage; Fibroblasts; Histones; Humans; Lymphocytes; Pharmacogenetics; Pyrroles

2013
Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.
    BMC veterinary research, 2015, Aug-19, Volume: 11

    Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Cell Line, Tumor; Cross-Linking Reagents; DNA; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Mice; Mice, Nude; Pyrroles; Xenograft Model Antitumor Assays

2015
Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink.
    Nucleic acids research, 2018, 09-28, Volume: 46, Issue:17

    Topics: Base Pairing; Base Sequence; Benzodiazepinones; Cell Cycle Proteins; Cloning, Molecular; Cross-Linking Reagents; DNA Damage; DNA Repair; DNA Replication; DNA, Single-Stranded; Escherichia coli; Exodeoxyribonucleases; Gene Expression; Humans; Nucleic Acid Conformation; Oligonucleotides; Plasmids; Pyrroles; Recombinant Proteins; Saccharomyces cerevisiae

2018