pyrroles and sjg 136
pyrroles has been researched along with sjg 136 in 30 studies
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (70.00) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Adams, LJ; Brooks, NA; Gregson, SJ; Hartley, JA; Howard, PW; Jenkins, TC; Kelland, LR; Thurston, DE | 1 |
| Cooper, P; Howard, PW; Jenkins, TC; Loadman, PM; Shnyder, S; Taylor, JP; Thurston, DE; Wilkinson, GP | 1 |
| Alley, MC; Brooks, N; Clingen, PH; Gregson, SJ; Hartley, JA; Hochhauser, D; Hollingshead, MG; Howard, PW; Kelland, LR; McHugh, PJ; Pedley, RB; Sausville, EA; Schultz, R; Schweikart, KM; Spanswick, VJ; Thurston, DE; Tomaszewski, JE | 1 |
| Alley, MC; Gregson, SJ; Hartley, JA; Hollingshead, MG; Howard, PW; Pacula-Cox, CM; Sausville, EA; Thurston, DE; Waud, WR | 1 |
| Delavault, P; Fegan, CD; Hambly, RM; Pepper, CJ; Thurston, DE | 1 |
| Kamal, A; Laxman, E; Murthy, YL; Reddy, DR; Reddy, PS | 1 |
| Ellis, T; Hartley, JA; Jenkins, TC; Martin, C; McGurk, CJ; Thurston, DE; Waring, MJ | 1 |
| Clingen, PH; De Silva, IU; Ghadessy, FJ; Hartley, JA; McHugh, PJ; Thurston, DE; Tilby, MJ | 1 |
| Cheung, A; He, J; Liu, P; Struble, E; Thurston, DE; Wang, E; Yang, C | 1 |
| Guichard, SM; Jodrell, DI; Macpherson, JS; Thurston, DE | 1 |
| Veryard, C | 1 |
| Ames, MM; Buhrow, SA; Covey, JM; Grossi, IM; Jia, L; Kobs, DJ; McGovern, RM; Reid, JM | 1 |
| Arnould, S; Guichard, SM; Hartley, JA; Jodrell, DI; Macpherson, JS; Spanswick, VJ; Thurston, DE | 1 |
| Bibby, MC; Cooper, PA; Shnyder, SD; Suggitt, M | 1 |
| Aird, RE; Guichard, SM; Jodrell, DI; Macpherson, JS; Thomson, M; Thurston, DE | 1 |
| Delavault, P; Fegan, C; Hartley, JA; Lowe, H; Pepper, C; Thurieau, C; Thurston, DE | 1 |
| Hachey, DL; Lee, W; Puzanov, I; Rothenberg, ML; Wade Calcutt, M | 1 |
| Griffiths, WJ; Howard, PW; Narayanaswamy, M; Thurston, DE | 1 |
| Begent, RH; Clingen, PH; Cobb, M; Gumbrell, L; Hartley, JA; Hochhauser, D; Jodrell, D; Loadman, P; Meyer, T; Spanswick, VJ; Wu, J | 1 |
| Azzoli, CG; Calcutt, MW; Janjigian, YY; Kris, MG; Krug, LM; Lee, W; Miller, VA; Rizvi, NA; Senturk, E | 1 |
| James, CH; Narayanaswamy, M; Rahman, KM; Thompson, AS; Thurston, DE | 1 |
| Chen, Z; Coffils, MJ; Cooper, N; Fang, M; Gregson, SJ; Hartley, JA; Howard, PW; Klee, S; Masterson, LA; Thurston, DE; Tiberghien, AC | 1 |
| Ames, MM; Buhrow, SA; Hartley, JA; Jia, L; Kuffel, MJ; Reid, JM; Spanswick, VJ; Thurston, DE; Tomaszewski, JE | 1 |
| Berlin, JD; Calcutt, MW; Chen, AP; Hachey, DL; Hartley, JA; Lee, W; Liao, CY; Puzanov, I; Rothenberg, ML; Spanswick, VJ; Vermeulen, WL | 1 |
| James, CH; Rahman, KM; Thurston, DE | 1 |
| Hartley, JA | 1 |
| Hartley, JA; Hochhauser, D | 1 |
| Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J | 1 |
| Baines, SJ; Hartley, JA; Mellinas-Gomez, M; Paredes-Moscosso, SR; Pedley, RB; Robson, M; Spanswick, VJ; Stell, A; Thurston, DE | 1 |
| Buzon, B; Grainger, R; Huang, S; Junop, MS; Rzadki, C | 1 |
Reviews
2 review(s) available for pyrroles and sjg 136
| Article | Year |
|---|---|
The development of pyrrolobenzodiazepines as antitumour agents.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; DNA Damage; Drug Delivery Systems; Drug Design; Humans; Neoplasms; Pyrroles; Structure-Activity Relationship | 2011 |
Small molecule drugs - optimizing DNA damaging agent-based therapeutics.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Benzodiazepinones; Dioxoles; DNA; DNA Damage; Humans; Neoplasms; Nitrogen Mustard Compounds; Pyrroles; Tetrahydroisoquinolines; Trabectedin | 2012 |
Trials
3 trial(s) available for pyrroles and sjg 136
| Article | Year |
|---|---|
Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Benzodiazepinones; DNA; Histones; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles | 2009 |
A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.
Topics: Aged; Antineoplastic Agents; Benzodiazepinones; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Ovarian Neoplasms; Pyrroles; Urinary Bladder Neoplasms | 2010 |
Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Benzodiazepinones; Dexamethasone; Dyspnea; Edema; Fatigue; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrroles | 2011 |
Other Studies
25 other study(ies) available for pyrroles and sjg 136
| Article | Year |
|---|---|
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Topics: Antineoplastic Agents; Benzodiazepinones; Cisplatin; Cross-Linking Reagents; DNA; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Electrophoresis, Agar Gel; Heating; Humans; Models, Molecular; Protein Denaturation; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Blood Proteins; Cell Line, Tumor; Chromatography, Liquid; Cross-Linking Reagents; Dimerization; DNA; Drug Screening Assays, Antitumor; Drug Stability; Female; In Vitro Techniques; Mass Spectrometry; Mice; Mice, Nude; Protein Binding; Pyrroles | 2004 |
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Comet Assay; Cross-Linking Reagents; DNA; Dogs; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Pyrroles; Xenograft Model Antitumor Assays | 2004 |
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Cross-Linking Reagents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Mice; Mice, Nude; Pyrroles; Rats; Rats, Nude; Urea; Xenograft Model Antitumor Assays | 2004 |
The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
Topics: Apoptosis; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Case-Control Studies; Caspase 3; Caspases; Cross-Linking Reagents; DNA Damage; DNA Repair; Enzyme Activation; Humans; K562 Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrroles; T-Lymphocytes; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vidarabine | 2004 |
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
Topics: Benzodiazepines; Benzodiazepinones; Binding Sites; DNA; Fluorine Compounds; Molecular Conformation; Pyrroles; Structure-Activity Relationship | 2004 |
Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Topics: Bacterial Proteins; Bacteriophage T7; Base Sequence; Benzodiazepinones; Capsid Proteins; Cross-Linking Reagents; Deoxyribonuclease I; Deoxyribonucleases, Type II Site-Specific; DNA Footprinting; DNA, Single-Stranded; DNA, Viral; Enzyme Inhibitors; Molecular Sequence Data; Nucleic Acid Conformation; Polymerase Chain Reaction; Pyrroles; RNA-Binding Proteins; Sequence Analysis, DNA; Temperature; Transcription, Genetic | 2005 |
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.
Topics: Animals; Antineoplastic Agents; Benzodiazepines; Benzodiazepinones; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Melphalan; Pyrroles; Recombination, Genetic | 2005 |
Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501).
Topics: Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Drug Stability; Imines; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrroles | 2005 |
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepinones; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Humans; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Heterologous; Verapamil | 2005 |
AACR-NCI-EORTC--17th symposium: Molecular targets and cancer therapeutics. 14-18th November 2005, Philadelphia, PA, USA.
Topics: Angiopoietin-2; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzodiazepinones; Clinical Trials, Phase I as Topic; ErbB Receptors; Humans; Neoplasms; Ornithine; Pterins; Pyrroles; Receptor, EphA2; Societies, Scientific | 2006 |
LC-MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501).
Topics: Animals; Benzodiazepinones; Chromatography, High Pressure Liquid; Dogs; Humans; Mass Spectrometry; Mice; Protein Binding; Pyrroles; Rats; Reference Standards | 2006 |
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
Topics: Benzodiazepinones; Cell Survival; Checkpoint Kinase 1; Cross-Linking Reagents; DNA; DNA Damage; HCT116 Cells; Humans; Phosphorylation; Protein Kinases; Pyrroles; S Phase; Signal Transduction; Time Factors | 2006 |
The hollow fibre model--facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare.
Topics: Aminoacridines; Animal Welfare; Animals; Benzodiazepinones; Cell Growth Processes; Comet Assay; Drug Screening Assays, Antitumor; Female; HL-60 Cells; HT29 Cells; Humans; Mice; Microscopy, Fluorescence; Mitomycin; Neoplasm Transplantation; Pyrroles; Transplantation, Heterologous | 2006 |
ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Benzodiazepinones; Cell Line, Transformed; Cell Line, Tumor; Gene Expression Regulation; Humans; Mice; Polymorphism, Genetic; Pyrroles | 2008 |
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cross-Linking Reagents; DNA; DNA Repair; DNA-Binding Proteins; Drug Synergism; Endonucleases; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pyrroles; Transcription, Genetic; Tumor Cells, Cultured; Vidarabine | 2007 |
Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study.
Topics: Antineoplastic Agents; Benzodiazepinones; Chromatography, High Pressure Liquid; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Humans; Oxidation-Reduction; Pyrroles; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences.
Topics: Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; Mass Spectrometry; Oligodeoxyribonucleotides; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
Topics: Base Sequence; Benzodiazepinones; Cross-Linking Reagents; Dimerization; DNA Adducts; Nucleic Acid Conformation; Pyrroles | 2009 |
Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Computer Simulation; DNA; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epoxy Compounds; Humans; Models, Molecular; Prodrugs; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship | 2009 |
Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzodiazepinones; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Comet Assay; DNA; DNA Damage; Half-Life; In Vitro Techniques; Indicators and Reagents; Male; Mass Spectrometry; Microsomes, Liver; Monocytes; Pharmaceutical Solutions; Pyrroles; Rats; Rats, Inbred F344 | 2011 |
Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.
Topics: Base Sequence; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dimerization; DNA; Mass Spectrometry; Models, Molecular; Oligonucleotides; Pyrroles | 2011 |
γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Topics: Benzodiazepinones; Comet Assay; DNA Damage; Fibroblasts; Histones; Humans; Lymphocytes; Pharmacogenetics; Pyrroles | 2013 |
Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours.
Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Cell Line, Tumor; Cross-Linking Reagents; DNA; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Mice; Mice, Nude; Pyrroles; Xenograft Model Antitumor Assays | 2015 |
Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink.
Topics: Base Pairing; Base Sequence; Benzodiazepinones; Cell Cycle Proteins; Cloning, Molecular; Cross-Linking Reagents; DNA Damage; DNA Repair; DNA Replication; DNA, Single-Stranded; Escherichia coli; Exodeoxyribonucleases; Gene Expression; Humans; Nucleic Acid Conformation; Oligonucleotides; Plasmids; Pyrroles; Recombinant Proteins; Saccharomyces cerevisiae | 2018 |