pyrroles and pd 98059
pyrroles has been researched along with pd 98059 in 43 studies
Research
Studies (43)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 27 (62.79) | 29.6817 |
| 2010's | 16 (37.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ardenghi, P; Barros, DM; Izquierdo, I; Izquierdo, LA; Medinam, JH; Mello e Souza, T; Rodrigues, C; Sant'Anna, MK; Vianna, M | 1 |
| Chun, JS; Kang, SS; Oh, CD; Yoon, YM | 1 |
| Bucana, CD; Ellis, LM; Gallick, GE; Jung, YD; McConkey, DJ; McMahon, G; Solorzano, CC | 1 |
| Larsson, C; Svensson, K; Trollér, U; Zeidman, R | 1 |
| Ho, J; Lau, HK | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Itoh, N; Konishi, M; Mikami, T; Miyake, A; Ohmachi, S | 1 |
| Fujisawa, K; Hata, Y; Honda, M; Ishibashi, T; Sakamoto, T; Sassa, Y; Shiose, S; Takeda, A | 1 |
| Li, L; Renier, G; Sawamura, T | 1 |
| Huang, SH; Shen, WJ; Wang, SM; Yeo, HL | 1 |
| Gounko, NV; Gramsbergen, A; IJkema-Paassen, J; Metzger, F; Swinny, JD; van der Want, JJ | 1 |
| Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L | 1 |
| Cui, Q; Harvey, AR; Hisheh, S; Luo, JM; Park, K | 1 |
| Andrassy, M; Belov, D; Harja, E; Katus, HA; Leitges, M; Nawroth, PP; Schmidt, AM; Yan, SD; Yan, SF; Zou, YS | 1 |
| Goez, P; Hagelgans, A; Hempel, U; Heyne, B; Jaross, W; Menschikowski, M; Neumeister, V; Siegert, G | 1 |
| Fukuda, T; Ishii, K; Isobe, K; Kawakami, Y; Nanmoku, T; Takekoshi, K | 1 |
| Matsumura, F; Park, S | 1 |
| Hirade, K; Ishisaki, A; Kozawa, O; Matsuno, H; Nakajima, K; Suga, H | 1 |
| Hirase, T; Inoue, T; Node, K; Wang, D | 1 |
| Eggo, MC; Susarla, R; Watkinson, JC | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| Choi, JW; Choi, MS; Go, HS; Jeon, SJ; Kim, SD; Kim, WK; Kim, YE; Ko, KH; Lee, WJ; Park, GH; Shin, CY; Shin, SM | 1 |
| Bertone, C; Bianco, MJ; Brama, M; Castelli, A; Rossi, F; Santiemma, V | 1 |
| Frick, A; Johnston, D; Rosenkranz, JA | 1 |
| Firth, JD; Li, M; Putnins, EE | 1 |
| Chen, CL; Lo, HM; Tsai, YJ; Wu, PH; Wu, WB | 1 |
| Kohsaka, S; Maeda, S; Nakajima, K; Tohyama, Y | 1 |
| Cwynarski, K; Hart, SM; Hoffbrand, AV; Lowdell, MW; Prentice, AG; Samuel, ER; Steele, AJ; Wickremasinghe, RG | 1 |
| Makarevich, AV; Rafay, J; Sirotkin, AV | 1 |
| Chen, G; Deng, CQ; Wu, L | 1 |
| Aritake, K; Hori, M; Matsuoka, T; Michishita, M; Murata, T; Narumiya, S; Ozaki, H; Tajima, T; Urade, Y | 1 |
| Esliger, A; Hurley, MM; Xiao, L | 1 |
| Lin, CI; Moalem, J; Ruan, DT; Whang, EE | 1 |
| Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z | 1 |
| Deng, L; Gao, H | 1 |
| Crews, LA; Gonzales, T; Kouznetsova, VL; Masliah, E; Overk, CR; Patrick, C; Paulino, A; Price, D; Rockenstein, E; Stocking, E; Tsigelny, IF; Wrasidlo, W | 1 |
| Fan, C; Hu, X; Jin, C; Liu, Y; Lu, X; Tao, H; Wang, X; Zhu, Y | 1 |
| Lee, JY; Lee, NK; No, JH; Oh, JH; Park, JH | 1 |
| Deng, X; Gu, W; Jin, K; Li, Y; Liu, M; Zhou, L | 1 |
| Hu, X; Jin, C; Liu, Y; Lu, X; Tao, H; Wang, X; Zhu, Y | 1 |
| Cheng, XD; Feng, L; Gu, JF; Jia, XB; Yuan, JR | 1 |
| Baran, CN; Clason, TA; Girard, BM; Hardwick, JC; May, V; Merriam, LA; Parsons, RL; Tompkins, JD | 1 |
| Almeida, VH; Berzoti-Coelho, MG; Borges, CS; Cacemiro, MDC; Castro, FA; Ferreira, AF; Figueiredo-Pontes, LL; Gomes, FG; Monteiro, RQ; Nunes, NS; Simões, BP | 1 |
Other Studies
43 other study(ies) available for pyrroles and pd 98059
| Article | Year |
|---|---|
Short- and long-term memory are differentially affected by metabolic inhibitors given into hippocampus and entorhinal cortex.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Animals; Avoidance Learning; Carbazoles; Entorhinal Cortex; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Hippocampus; Indoles; Inhibition, Psychological; Male; Memory; Memory, Short-Term; Phenols; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Staurosporine | 2000 |
Protein kinase A regulates chondrogenesis of mesenchymal cells at the post-precartilage condensation stage via protein kinase C-alpha signaling.
Topics: Animals; Cadherins; Carbazoles; Cartilage; Cell Differentiation; Chick Embryo; Chondrogenesis; Cyclic AMP-Dependent Protein Kinases; Embryonic Induction; Enzyme Inhibitors; Fibronectins; Flavonoids; Indoles; Isoenzymes; Isoquinolines; Mesoderm; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Pyrroles; Receptors, Fibronectin; Signal Transduction; Sulfonamides | 2000 |
In vivo intracellular signaling as a marker of antiangiogenic activity.
Topics: Androstadienes; Angiogenesis Inhibitors; Biomarkers, Tumor; Blotting, Western; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Indoles; Liver Neoplasms; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Oxindoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2001 |
A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells.
Topics: Cell Differentiation; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; GAP-43 Protein; Gene Expression Regulation; Genes, Reporter; Isoenzymes; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurites; Neuroblastoma; Neurons; Neuropeptide Y; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Pyrroles; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Isoquinolines; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Rats; Signal Transduction; src-Family Kinases; Stilbenes; Sulfonamides; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2002 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c.
Topics: Animals; Cell Survival; Cells, Cultured; Dopamine; Enzyme Inhibitors; Fibroblast Growth Factors; Flavonoids; In Situ Hybridization; Mesencephalon; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; RNA, Messenger; Signal Transduction | 2003 |
Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Choroidal Neovascularization; Endothelium, Corneal; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Phosphorylation; Protein-Tyrosine Kinases; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2003 |
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Topics: Acetylcysteine; Adult; Aged; Anti-Infective Agents; Antioxidants; Arteriosclerosis; Cells, Cultured; Curcumin; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Flavonoids; Foam Cells; Gene Expression Regulation; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Macrophages; Male; MAP Kinase Signaling System; Mesylates; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Processing, Post-Translational; Pyrroles; Receptors, LDL; RNA, Messenger; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2004 |
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles | 2004 |
Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calbindins; Carbazoles; Cell Count; Cell Differentiation; Corticotropin-Releasing Hormone; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flavonoids; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Indoles; Linear Models; Neuroprotective Agents; Purkinje Cells; Pyrimidines; Pyrroles; Rats; S100 Calcium Binding Protein G; Time Factors; Urocortins | 2004 |
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate | 2004 |
Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.
Topics: Animals; Axons; Carbazoles; Cell Survival; Chromones; Ciliary Neurotrophic Factor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Flavonoids; Indoles; MAP Kinase Signaling System; Morpholines; Nerve Regeneration; Optic Nerve Injuries; Peroneal Nerve; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Inbred F344; Receptor, Ciliary Neurotrophic Factor; Retinal Ganglion Cells; Signal Transduction; STAT3 Transcription Factor; Thionucleotides; Trans-Activators; Tyrphostins; Up-Regulation | 2004 |
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.
Topics: Animals; Aorta; Blood Glucose; Cell Division; Cell Movement; Cells, Cultured; Constriction, Pathologic; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Femoral Artery; Flavonoids; Humans; Immediate-Early Proteins; Indoles; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; Maleimides; Mesylates; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Peroxidase; Protein Kinase C; Protein Kinase C beta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Tunica Intima | 2005 |
Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.
Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation | 2005 |
Stimulation of catecholamine biosynthesis via the PKC pathway by prolactin-releasing peptide in PC12 rat pheochromocytoma cells.
Topics: Animals; Catecholamines; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Hypothalamic Hormones; Indoles; Isoquinolines; MAP Kinase Signaling System; Neuropeptides; Pheochromocytoma; Prolactin-Releasing Hormone; Protein Kinase C; Pyrroles; Rats; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tyrosine 3-Monooxygenase | 2005 |
Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A.
Topics: Adaptation, Physiological; alpha 1-Antitrypsin; Apoptosis; bcl-2-Associated X Protein; Benzoflavones; Butadienes; Cell Line; DNA Fragmentation; Epidermal Growth Factor; Epithelial Cells; Female; Ferric Compounds; Flavonoids; Glutathione; Humans; Hydrogen Peroxide; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Nitriles; Nitro Compounds; Phenanthrolines; Polychlorinated Dibenzodioxins; Pyrimidines; Pyrroles; Quaternary Ammonium Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Ultraviolet Rays | 2006 |
Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Heptanoic Acids; Imidazoles; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrroles; Vascular Endothelial Growth Factor A | 2006 |
Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Atorvastatin; Benzimidazoles; Biphenyl Compounds; Calcium Channels, T-Type; Cells, Cultured; Endothelial Cells; Flavonoids; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Microscopy, Fluorescence; Pyrroles; ras Proteins; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazoles; Vasoconstrictor Agents | 2006 |
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.
Topics: Adenylyl Cyclases; Aprotinin; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activators; Epidermal Growth Factor; Fibroblast Growth Factors; Flavonoids; Humans; Indoles; Insulin; Iodine; Iodine Radioisotopes; Maleimides; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Plasminogen Inactivators; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2007 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Thrombin | 2008 |
Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.
Topics: Adenine; Androstadienes; Aorta; Carbazoles; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Flavonoids; Ghrelin; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Wortmannin | 2008 |
Kinase-dependent modification of dendritic excitability after long-term potentiation.
Topics: Animals; Butadienes; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dendrites; Electric Stimulation; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Flavonoids; In Vitro Techniques; Learning; Long-Term Potentiation; Male; Nitriles; Protein Kinase Inhibitors; Pyramidal Cells; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction | 2009 |
An in vitro analysis of mechanical wounding-induced ligand-independent KGFR activation.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Keratinocytes; Ligands; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein-Tyrosine Kinases; Pyrroles; Reactive Oxygen Species; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; src-Family Kinases; Wound Healing | 2009 |
Thrombin induces cyclooxygenase-2 expression and prostaglandin E2 release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages.
Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Imidazoles; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Thrombin; Thromboxane A2 | 2009 |
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFbeta3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB si
Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolysin; Fibrinolytic Agents; Fibroblast Growth Factors; Flavonoids; Immunohistochemistry; Microglia; Morpholines; Nerve Growth Factors; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta3 | 2009 |
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.
Topics: Apoptosis; bcl-X Protein; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cytochromes c; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Interleukin-4; Janus Kinase 3; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles; STAT6 Transcription Factor; Stromal Cells; T-Lymphocytes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2010 |
Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions.
Topics: Animals; Carbazoles; Cell Extracts; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinases; Female; Flavonoids; Granulosa Cells; Insulin-Like Growth Factor I; Kinetin; Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Pyrroles; Rabbits | 2010 |
The effects of BuYang HuanWu Decoction and its effective components on proliferation-related factors and ERK1/2 signal transduction pathway in cultured vascular smooth muscle cells.
Topics: Alkaloids; Animals; Atorvastatin; Cardiovascular Agents; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycosides; Heptanoic Acids; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction | 2011 |
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.
Topics: Animals; Carbazoles; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Flavonoids; Gastrointestinal Motility; Ileum; Isoxazoles; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Pyrroles; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfones; Up-Regulation | 2012 |
Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro.
Topics: Animals; Calcification, Physiologic; Cell Nucleus; Culture Media, Conditioned; Fibroblast Growth Factor 2; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Humans; Male; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Weight; Neutralization Tests; Osteocalcin; Osteogenesis; Phosphorylation; Protein Isoforms; Pyrroles; Receptors, Fibroblast Growth Factor; RNA, Messenger; Time Factors | 2013 |
Strategic combination therapy overcomes tyrosine kinase coactivation in adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antineoplastic Combined Chemotherapy Protocols; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Humans; Indoles; Phosphorylation; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Sunitinib | 2012 |
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones | 2013 |
Sphingosine kinase-1 activation causes acquired resistance against Sunitinib in renal cell carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Indoles; Kidney Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Sunitinib | 2014 |
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
Topics: AIDS Dementia Complex; Animals; Antineoplastic Agents; Cyclin-Dependent Kinase 5; Dasatinib; Erlotinib Hydrochloride; Flavonoids; HIV Envelope Protein gp120; In Vitro Techniques; Indoles; Lapatinib; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Rats; Roscovitine; Sunitinib; Thiazoles | 2014 |
Interaction of ERK1/2 and Smad2/3 signaling pathways in TGF-β1-induced TIMP-3 expression in rat chondrocytes.
Topics: Animals; Cells, Cultured; Chondrocytes; Enzyme Activation; Flavonoids; Imidazoles; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinoxalines; Rats; Smad2 Protein; Smad3 Protein; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL.
Topics: Animals; Apoptosis; Cell Fusion; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Gene Silencing; Indoles; MAP Kinase Signaling System; Membrane Proteins; Mice, Inbred C57BL; Nerve Tissue Proteins; Osteoclasts; Pyrroles; RANK Ligand; Vacuolar Proton-Translocating ATPases | 2015 |
Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
Topics: Actins; Cell Line; Cell Proliferation; Collagen Type I; Fetus; Fibroblasts; Fibrosis; Flavonoids; Gene Expression Regulation; Humans; Isoquinolines; Lung; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways.
Topics: Aggrecans; Animals; Cartilage, Articular; Chondrocytes; Collagen Type II; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Primary Cell Culture; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.
Topics: Antineoplastic Agents; Apoptosis; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Flavonoids; Humans; Integrin beta1; Isoflavones; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phorbol Esters; Protein Kinase C-alpha; Pyrroles; Quinazolines; Signal Transduction | 2015 |
Recruitment of endosomal signaling mediates the forskolin modulation of guinea pig cardiac neuron excitability.
Topics: Adenylyl Cyclases; Animals; Carbazoles; Clathrin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endosomes; Flavonoids; Guinea Pigs; Heart; Humans; MAP Kinase Signaling System; Myocardium; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Pyrroles; Receptors, G-Protein-Coupled; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I | 2017 |
Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A | 2018 |