pyrroles has been researched along with pbox-6 in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campiani, G; Fattorusso, C; Lawler, M; Mc Gee, MM; Nacci, V; Ramunno, A; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Lawler, M; Mc Gee, MM; Nacci, V; Ramunno, A; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Hyland, E; Mc Gee, MM; Nacci, V; Ramunno, A; Zisterer, DM | 1 |
| Campiani, G; Greene, LM; Lawler, M; Ledwidge, S; Mc Gee, MM; Nacci, V; Williams, DC; Zisterer, DM | 1 |
| Atkins, GJ; Campiani, G; Fleeton, M; Gowda, C; Greene, LM; Lawler, M; Mulligan, J; Nacci, V; Sheahan, BJ; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Cloonan, S; Fattorusso, C; Greene, LM; Lawler, M; Mc Gee, MM; Mulligan, JM; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Mc Gee, MM; McGrath, LB; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Greene, LM; Kelly, L; Lawler, M; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Greene, LM; Lawler, M; Williams, DC; Zisterer, DM | 1 |
| Bane, FT; Bannon, JH; Campaini, G; Campiani, G; Mc Gee, MM; Pennington, SR; Williams, DC; Zisterer, DM | 1 |
| Butler, S; Campiani, G; Lawler, M; Meegan, MJ; Nathwani, SM; Williams, DC; Zisterer, DM | 1 |
| Butler, S; Campiani, G; Fayne, D; Lawler, M; Lloyd, DG; McGovern, NN; Meegan, MJ; Nathwani, SM; Sarkadi, B; Williams, DC; Zisterer, DM | 1 |
| Bright, SA; Campiani, G; Deininger, MW; Lawler, M; Williams, DC; Zisterer, DM | 1 |
| Bright, SA; Campiani, G; Carroll, P; Conneally, E; Deininger, MW; Lawler, M; McElligott, AM; O'Connell, JW; O'Connor, L; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Cloonan, SM; Lawler, M; Nathwani, SM; Stronach, M; Williams, DC; Zisterer, DM | 1 |
| Campiani, G; Greene, LM; Nolan, DP; Regan-Komito, D; Williams, DC; Zisterer, DM | 1 |
| Bright, SA; Butini, S; Campiani, G; Carroll, E; Lennon, JC; O'Meara, A; Williams, DC; Zisterer, DM | 1 |
| Butini, S; Campiani, G; O'Callaghan, K; O'Sullivan, J; Palagano, E; Williams, DC; Zisterer, DM | 1 |
| Butini, S; Campiani, G; Lennon, JC; O'Meara, A; Williams, DC; Zisterer, DM | 1 |
19 other study(ies) available for pyrroles and pbox-6
| Article | Year |
|---|---|
Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Down-Regulation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Proteins, Fusion; Oxazepines; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Pyrroles; Reactive Oxygen Species; Tumor Cells, Cultured | 2001 |
Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.
Topics: Activating Transcription Factor 2; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Carrier Proteins; Cyclic AMP Response Element-Binding Protein; Dicumarol; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitogen-Activated Protein Kinases; Oxazepines; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyrroles; Signal Transduction; Substrate Specificity; Transcription Factors | 2002 |
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Caspase 3; Caspase 7; Caspases; DNA Fragmentation; Enzyme Activation; Female; Flow Cytometry; Humans; In Situ Nick-End Labeling; Oxazepines; Pyrroles; Tumor Cells, Cultured | 2002 |
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation o
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carbazoles; Dactinomycin; Drug Resistance, Neoplasm; Etoposide; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; K562 Cells; Leukemia; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; Oxazepines; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Subcellular Fractions; Tumor Cells, Cultured; Ultraviolet Rays | 2004 |
The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Survival; Female; Humans; Mice; Mice, Inbred BALB C; Oxazepines; Pyrroles; Receptor, ErbB-2; Receptors, Estrogen; Tumor Cells, Cultured | 2005 |
Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Binding, Competitive; Blotting, Western; Carbamates; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Colchicine; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; G2 Phase; Humans; K562 Cells; Metaphase; Microtubules; Oxazepines; Pyrroles; Time Factors; Tubulin; Vinblastine | 2006 |
Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn2+-dependent acidic endonuclease activity.
Topics: Apoptosis; Caspase 3; Cell Extracts; Cytoplasm; Deoxyribonucleases; DNA Fragmentation; Endonucleases; Humans; Hydrogen-Ion Concentration; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Manganese; Mitochondria; Oxazepines; Peptide Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Serine Endopeptidases | 2006 |
STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
Topics: Apoptosis; bcl-X Protein; Benzamides; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Fusion Proteins, bcr-abl; HL-60 Cells; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myeloid; Microtubules; Monocytes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oxazepines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Pyrroles | 2007 |
BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.
Topics: Apoptosis; Cell Line, Tumor; HL-60 Cells; Humans; K562 Cells; Mitosis; Neoplasms; Oxazepines; Protein Serine-Threonine Kinases; Pyrroles; Spindle Apparatus; Tubulin | 2008 |
The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1,
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Division; Cell Membrane; Cell Nucleus; Cyclophilin A; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; G2 Phase; Hematologic Neoplasms; Humans; Hydrolysis; Microtubules; Monocytes; NIMA-Interacting Peptidylprolyl Isomerase; Oxazepines; Paclitaxel; Peptide Mapping; Peptidylprolyl Isomerase; Pyrroles; Silver Staining; Trypsin | 2009 |
Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
Topics: Antineoplastic Agents; Benzazepines; Carbamates; Caspase 3; Caspase 7; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; Humans; Microtubules; Oxazepines; Pyrroles; Structure-Activity Relationship; Tubulin; Umbilical Veins | 2010 |
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzazepines; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Microtubules; Neoplasm Proteins; Neoplasms; Oxazepines; Pyrroles; Tubulin Modulators | 2010 |
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Flavonoids; Humans; Imatinib Mesylate; Inhibitor of Apoptosis Proteins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microtubule-Associated Proteins; Oxazepines; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Survivin | 2010 |
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Separation; Cell Survival; Drug Resistance, Neoplasm; Female; Flow Cytometry; Genes, abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Middle Aged; Mutation; Oxazepines; Pyrroles | 2010 |
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Male; Models, Biological; Oxazepines; Prostatic Neoplasms; Pyrroles; Tubulin Modulators | 2010 |
Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Humans; Lysosomes; Macrolides; Mice; Microtubule-Associated Proteins; Oxazepines; Pyrroles | 2013 |
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carboplatin; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Neuroblastoma; Oxazepines; Pyrroles; Up-Regulation | 2014 |
Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Mouth Neoplasms; Oxazepines; Proteolysis; Pyrroles | 2015 |
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Topics: Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carboplatin; Cell Line, Tumor; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neuroblastoma; Oxazepines; Phosphorylation; Pyrroles; Reactive Oxygen Species; Tubulin Modulators; Tumor Burden | 2016 |