pyrroles has been researched along with l 745870 in 65 studies
Timeframe | Studies, this research(%) | All Research% |
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pre-1990 | 0 (0.00) | 18.7374 |
1990's | 17 (26.15) | 18.2507 |
2000's | 28 (43.08) | 29.6817 |
2010's | 17 (26.15) | 24.3611 |
2020's | 3 (4.62) | 2.80 |
Authors | Studies |
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Baker, R; Broughton, HB; Curtis, NR; Emms, F; Freedman, SB; Kulagowski, JJ; Leeson, PD; Marwood, R; Mawer, IM; Patel, S; Ragan, CI; Ridgill, MP | 1 |
Audinot-Bouchez, V; Gobert, A; Millan, MJ; Newman-Tancredi, A | 1 |
Chavez-Eng, CM; Constanzer, ML; Matuszewski, BK | 1 |
Bristow, LJ; Kramer, MS; Kulagowski, J; Patel, S; Ragan, CI; Seabrook, GR | 1 |
Capiris, T; Connor, DT; Heffner, TG; MacKenzie, RG; Miller, SR; Pugsley, TA; Unangst, PC; Wise, LD | 1 |
Baskin, E; Bristow, LJ; Chapman, KL; Curtis, N; Emms, F; Fletcher, AE; Freedman, S; Graham, M; Knowles, M; Kulagowski, JJ; Leeson, PD; Lynch, JJ; Marwood, R; Matheson, S; Mcallister, G; Myers, J; Patel, S; Ragan, CI; Rathbone, D; Ridgill, M; Rupniak, NM; Watt, AP | 1 |
Cao, BJ; Rodgers, RJ | 1 |
Bristow, LJ; Collinson, N; Cook, GP; Curtis, N; Freedman, SB; Kulagowski, JJ; Leeson, PD; Patel, S; Ragan, CI; Ridgill, M; Saywell, KL; Tricklebank, MD | 1 |
Brooks, EW; Mansbach, RS; Sanner, MA; Zorn, SH | 1 |
Costanza, RM; Terry, P | 1 |
Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
Audinot, V; Brocco, M; Dekeyne, A; Gobert, A; Lejeune, F; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Peglion, JL; Rivet, JM; Schreiber, R; Spedding, M | 1 |
Brown, NA; McAllister, G; Milligan, G; Pillai, G; Seabrook, GR | 1 |
Gmeiner, P; Hübner, H; Löber, S | 1 |
Chari, S; Deth, RC; DuRand, CJ; Kotb, M; Kramer, ML; Liu, D; Nagata, M; Ouellette, D; Sharma, A; Shim, S; Tan, W; Wick, PF | 1 |
Bobirnac, I; Danzeisen, M; Gazi, L; Hoyer, D; Langenegger, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
Chaki, S; Kawashima, N; Okuyama, S; Omura, T; Tomisawa, K | 1 |
Clifford, JJ; Waddington, JL | 1 |
Baillie, TA; Davis, MR; Doss, G; Kari, PH; Vyas, KP; Zhang, KE | 1 |
De La Garza, R; Madras, BK | 1 |
Henry, BL; LaHoste, GJ; Marshall, JF | 1 |
Berardi, F; Chou, Y; Farde, L; Halldin, C; Langer, O; Leopoldo, M; Någren, K; Perrone, R; Sandell, J; Swahn, C | 1 |
Gmeiner, P; Lanig, H; Utz, W | 1 |
Bae, S; Huang, Y; Hwang, D; Kegeles, LS; Laruelle, M; Roth, BL; Savage, JE | 1 |
Nadelhaft, I; Vera, PL | 1 |
Berezińska, M; Nowak, JZ; Rosiak, J; Zawilska, JB | 1 |
Chapman, KL; Hutson, PH; Marston, D; Patel, S; Ragan, CI | 1 |
Chaperon, F; Neijt, HC; Tricklebank, MD; Unger, L | 1 |
Bernaerts, P; Tirelli, E | 1 |
Andersen, SL; Baldessarini, RJ; Grady, CJ; Tarazi, FI; Tsapakis, EM; Zhang, K | 1 |
Aceves, J; Erlij, D; Floran, B; Floran, L | 1 |
Jardemark, K; Konradsson, A; Marcus, MM; Svensson, TH | 1 |
Aceves, J; Gutiérrez, R; Romo-Parra, H | 1 |
Mamiya, T; Matsumura, T; Ukai, M | 1 |
Hadano, S; Ikeda, JE; Kohiki, E; Okada, Y; Osuga, H; Sakai, H; Suga, E; Tanaka, K; Yanagisawa, Y | 1 |
Brioni, JD; Chang, R; Cowart, MD; Donnelly-Roberts, DL; Hsieh, GC; Marsh, K; Miller, L; Miller, TR; Moreland, RB; Nakane, M; Namovic, MT; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
Mitsunaga, H; Ukai, M | 1 |
Allouchi, H; Argiolas, A; El Hakmaoui, A; Enguehard-Gueiffier, C; Gmeiner, P; Gueiffier, A; Hübner, H; Melis, MR | 1 |
Aceves, J; Anaya, V; Bargas, J; Galarraga, E; Hernández, A; Ibáñez-Sandoval, O; Sierra, A; Tapia, D; Valdiosera, R | 1 |
Argiolas, A; Enguehard-Gueiffier, C; Gmeiner, P; Gueiffier, A; Hubner, H; Mascia, MS; Melis, MR; Melis, T; Sanna, F; Succu, S | 1 |
Argiolas, A; Boi, A; Melis, MR; Melis, T; Sanna, F; Succu, S | 1 |
Agnati, L; De La Calle, A; Fuxe, K; Gago, B; Peñafiel, A; Rivera, A | 1 |
Aoki, M; Hadano, S; Ikeda, JE; Itoyama, Y; Kanno, T; Kohiki, E; Okada, Y; Onoe, K; Osuga, H; Otomo, A; Shouguchi-Miyata, J; Suga, E; Tanaka, K; Yanagisawa, Y | 1 |
Floresco, SB; St Onge, JR | 1 |
Braszko, JJ | 1 |
Fan, X; Hess, EJ; Xu, M | 1 |
Arai, Y; Kikuchi, T; Mitazaki, S; Nakagawasai, O; Nakaya, K; Niijima, F; Onogi, H; Sato, A; Tadano, T; Tan-No, K | 1 |
Agnati, LF; Brené, S; de la Calle, A; Fuxe, K; Gago, B; Reina-Sánchez, MD; Rivera, A; Rodríguez-Pérez, LM; Suárez-Boomgaard, D | 1 |
Barnes, C; Gamaleddin, I; Goldberg, SR; Justinova, Z; Le Foll, B; Le Strat, Y; Pushparaj, A; Yan, Y | 1 |
Aman, A; Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Koprich, JB | 1 |
Andersson, RH; Buonanno, A; Fisahn, A; Herman, PA; Johnston, A; Karavanova, I; Vullhorst, D; Winzer-Serhan, UH | 1 |
Argiolas, A; Corda, MG; Giorgi, O; Gmeiner, P; Hübner, H; Löber, S; Melis, MR; Piludu, MA; Sanna, F | 1 |
Cocker, PJ; Le Foll, B; Rogers, RD; Winstanley, CA | 1 |
Ikeda, K; Ikejiri, M; Ishiyama, T; Murai, T; Nakako, T; Taiji, M | 1 |
Di Ciano, P; Grandy, DK; Le Foll, B | 1 |
Cruz-Martínez, AM; Escartín-Pérez, RE; Florán-Garduño, B; García-Iglesias, B; López-Alonso, VE; Mancilla-Díaz, JM; Tejas-Juárez, JG | 1 |
Brotchie, JM; Espinosa, MC; Fox, SH; Huot, P; Johnston, TH; Koprich, JB; Reyes, MG | 1 |
Connolly, NP; Gomez-Serrano, M | 1 |
Jensen, R | 1 |
Fuentealba, JA; Gysling, K; Keller, VN; Vergara, MD | 1 |
Meltzer, HY; Miyauchi, M; Neugebauer, NM | 1 |
Cao, C; He, L; Wang, X; Zhang, XC; Zhou, Y | 1 |
Di Ciano, P; Kim, A; Le Foll, B; Leca, J; Pushparaj, A | 1 |
Chen, JC; Liao, IM | 1 |
Amaral, J; Bharti, K; Bose, D; Campos, MM; Chang, J; Dejene, R; Ferrer, M; George, A; Hanson, E; Jha, BS; Karla, BS; King, R; Lal, M; Liang, G; McGaughey, D; Memon, O; Miyagishima, KJ; Nimmagadda, M; Ortolan, D; Qureshy, Z; Rising, A; Sharma, R; Wan, Q | 1 |
2 review(s) available for pyrroles and l 745870
Article | Year |
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Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.
Topics: Animals; Antipsychotic Agents; Biological Availability; Clinical Trials as Topic; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4; Rodentia; Schizophrenia | 1997 |
Dopamine D4 receptors in psychostimulant addiction.
Topics: Animals; Central Nervous System Stimulants; Cocaine-Related Disorders; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4; Substance-Related Disorders | 2014 |
63 other study(ies) available for pyrroles and l 745870
Article | Year |
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3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Topics: Animals; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1996 |
Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agonists; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Norepinephrine; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Sulfur Radioisotopes; Thermodynamics | 1997 |
Picogram determination of a novel dopamine D4 receptor antagonist in human plasma and urine by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Dopamine D2 Receptor Antagonists; Humans; Mass Spectrometry; Microchemistry; Pyridines; Pyrroles; Receptors, Dopamine D4; Sensitivity and Specificity | 1997 |
Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cloning, Molecular; Cricetinae; Dopamine D2 Receptor Antagonists; Humans; Kinetics; Levodopa; Models, Chemical; Piperazines; Pyridines; Pyridones; Pyrroles; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship; Sulfonamides | 1997 |
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Phenazocine; Prolactin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Saimiri | 1997 |
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1997 |
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Mice; Motor Activity; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D4 | 1997 |
Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition.
Topics: Animals; Apomorphine; Cell Line; Dopamine Antagonists; Humans; Male; Piperazines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Reflex, Startle; Sulfonamides | 1998 |
The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline.
Topics: Animals; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Antagonists; Male; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1998 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-
Topics: Animals; Basal Ganglia Diseases; Body Temperature; Brain; Dioxins; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperazines; Pyridines; Pyrroles; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D4; Receptors, sigma; Salicylamides; Serotonin | 1998 |
Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively.
Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Indoles; Ion Channel Gating; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1998 |
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Indoles; Isomerism; Kinetics; Models, Chemical; Pyrazoles; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Static Electricity; Structure-Activity Relationship; Surface Properties | 1999 |
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Benzazepines; Binding Sites; Carbon Radioisotopes; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Formates; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methionine; Mutagenesis, Site-Directed; Neuroblastoma; Phospholipids; Phosphorylation; Piperidines; Psychotic Disorders; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; S-Adenosylmethionine; Salicylamides; Schizophrenia; Transfection; Tumor Cells, Cultured | 1999 |
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells.
Topics: Aminopyridines; Animals; Butyrates; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agents; Humans; Ligands; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Spiperone | 1999 |
Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats.
Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Neurons; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Substantia Nigra; Thiazoles; Ventral Tegmental Area | 1999 |
Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Habituation, Psychophysiologic; Male; Psychotic Disorders; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 2000 |
Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct.
Topics: Acetylcysteine; Animals; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Macaca mulatta; Male; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 2000 |
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain.
Topics: Aminopyridines; Animals; Autoradiography; Brain; Hippocampus; Macaca mulatta; Molecular Probes; Piperidines; Prefrontal Cortex; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tritium | 2000 |
Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials.
Topics: Action Potentials; Amphetamine; Animals; Corpus Striatum; Dopamine Antagonists; Genes, fos; Indans; Indoles; Male; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrodotoxin | 2000 |
Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography.
Topics: Animals; Benzamides; Brain; Female; Injections, Intravenous; Isotope Labeling; Ligands; Macaca fascicularis; Piperazines; Pyridines; Pyrroles; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tomography, Emission-Computed | 2000 |
Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapi
Topics: Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Models, Molecular; Pyrazoles; Pyridines; Pyrroles; Receptors, Dopamine D4 | 2001 |
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.
Topics: Binding Sites; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Tomography, Emission-Computed | 2001 |
Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats.
Topics: Anesthesia; Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Female; Haloperidol; Hypogastric Plexus; Pyridines; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Urinary Bladder; Urination; Urination Disorders | 2001 |
L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors.
Topics: Animals; Arylamine N-Acetyltransferase; Chickens; Circadian Rhythm; Darkness; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Male; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Serotonin | 2003 |
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Topics: Animals; Binding Sites; Cyclic AMP; Darkness; Dopamine Agonists; Dopamine Antagonists; In Vitro Techniques; Indoles; Male; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Spiperone | 2003 |
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.
Topics: Animals; Aporphines; Benzazepines; Benzopyrans; Body Temperature Regulation; Dopamine Agonists; Dopamine Antagonists; Hypothermia; Indoles; Oxazines; Piperazines; Piperidines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4 | 2003 |
Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Benzamides; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Inhibition, Psychological; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperazines; Pyridines; Pyrroles; Reaction Time; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4 | 2003 |
Regulation of working memory by dopamine D4 receptor in rats.
Topics: Animals; Attention; Conditioning, Operant; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Memory, Short-Term; Psychomotor Performance; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 2004 |
Dopamine D4 receptors inhibit depolarization-induced [3H]GABA release in the rat subthalamic nucleus.
Topics: Animals; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Methamphetamine; Methylphenidate; Potassium; Pyridines; Pyrroles; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Subthalamic Nucleus; Sulpiride; Tritium | 2004 |
The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Dopamine Antagonists; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; N-Methylaspartate; Nicotine; Prefrontal Cortex; Pyramidal Cells; Pyridines; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Tonic modulation of inhibition by dopamine D4 receptors in the rat hippocampus.
Topics: Animals; Clozapine; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; GABA Antagonists; Hippocampus; Male; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Perforant Pathway; Pyridines; Pyrroles; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Synapses | 2005 |
Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice.
Topics: Animals; Cyclic AMP; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Mice; Morphine Dependence; Naloxone; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Substance Withdrawal Syndrome | 2004 |
A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.
Topics: Animals; Apoptosis; Cell Line; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Gerbillinae; Hippocampus; Humans; Ischemia; Male; Nerve Tissue Proteins; Neuronal Apoptosis-Inhibitory Protein; Neurons; Oxidative Stress; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Up-Regulation; Vitamin K 3 | 2005 |
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Topics: Animals; Benzamides; Benzimidazoles; Binding, Competitive; Calcium; Cell Line; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Europium; Fluorometry; GABA Antagonists; Guanosine Triphosphate; Humans; Male; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spiperone; Time Factors; Tritium | 2005 |
Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat.
Topics: Animals; Biphenyl Compounds; Bromocriptine; Cocaine; Discrimination, Psychological; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Inbred F344; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrahydronaphthalenes | 2005 |
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Topics: Animals; Cattle; CHO Cells; Cricetinae; Cricetulus; Erectile Dysfunction; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Ligands; Male; Mitosis; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Receptors, Dopamine D4; Structure-Activity Relationship | 2006 |
Control of the subthalamic innervation of the rat globus pallidus by D2/3 and D4 dopamine receptors.
Topics: Algorithms; Animals; Benzamides; Dopamine; Dopamine Agonists; Electric Stimulation; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Histocytochemistry; In Vitro Techniques; Neural Pathways; Patch-Clamp Techniques; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Subthalamus; Synapses | 2006 |
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain.
Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Brain; Calcium Channel Blockers; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Imidazoles; Male; Nitrates; Nitric Oxide; Nitrites; omega-Conotoxins; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4 | 2006 |
Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzamides; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Electrochemistry; Male; Microinjections; Nucleus Accumbens; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine | 2007 |
Dopamine D(4) receptor activation decreases the expression of mu-opioid receptors in the rat striatum.
Topics: Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Receptors, Opioid, mu; Time Factors | 2007 |
A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Movement; Disease Models, Animal; Disease Progression; Dopamine Antagonists; Female; Humans; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyridines; Pyrroles; Spinal Cord | 2008 |
Dopaminergic modulation of risk-based decision making.
Topics: Animals; Behavior, Animal; Benzamides; Benzazepines; Benzopyrans; Bromocriptine; Conditioning, Operant; Decision Making; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Naphthalenes; Oxazines; Piperazines; Pyridines; Pyrroles; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Reinforcement Schedule; Risk; Salicylamides | 2009 |
Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats.
Topics: Angiotensin II; Animals; Anxiety; Avoidance Learning; Cognition; Data Interpretation, Statistical; Dopamine Antagonists; Exploratory Behavior; Form Perception; Injections, Intraventricular; Male; Maze Learning; Mental Recall; Motor Activity; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D4; Recognition, Psychology | 2009 |
D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Benzopyrans; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Space; Indoles; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4 | 2010 |
p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission.
Topics: Animals; Benzazepines; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Oxidopamine; p-Hydroxyamphetamine; Piperazines; Piperidines; Pyridines; Pyrroles; Reflex, Startle; Salicylamides; Sensory Gating; Sympathomimetics; Synaptic Transmission | 2010 |
Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation.
Topics: Analgesics, Opioid; Animals; Autoradiography; Benzamides; Caudate Nucleus; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dopamine Antagonists; Genes, fos; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Piperazines; Proto-Oncogene Proteins c-fos; Putamen; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Transcription Factors | 2011 |
Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats.
Topics: Animals; Behavior, Animal; Discrimination Learning; Dopamine Antagonists; Drug-Seeking Behavior; Extinction, Psychological; Male; Nicotine; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Dopamine D4; Reinforcement, Psychology; Self Administration | 2012 |
L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Brain; Drug Interactions; Dyskinesias; Female; Levodopa; Macaca; Male; Motor Activity; Parkinson Disease; Pyridines; Pyrroles; Receptors, Dopamine D4 | 2012 |
Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.
Topics: Animals; Brain Waves; Dopamine; Fluorescent Antibody Technique; Fourier Analysis; Hippocampus; Immunohistochemistry; In Situ Hybridization; Interneurons; Neuregulins; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2012 |
Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats.
Topics: Animals; Avoidance Learning; Benzamides; Dopamine Agonists; Penile Erection; Piperazines; Pyrazoles; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity; Yawning | 2013 |
A selective role for dopamine D₄ receptors in modulating reward expectancy in a rodent slot machine task.
Topics: Animals; Benzamides; Dopamine Agonists; Dopamine Antagonists; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Dopamine D4; Reward; Risk-Taking | 2014 |
Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone.
Topics: Animals; Antipsychotic Agents; Callithrix; Cognition; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Female; Isoindoles; Lurasidone Hydrochloride; Male; Mental Recall; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Receptors, Dopamine D4; Thiazoles | 2014 |
Stimulation of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus of male rats induces hyperphagia: involvement of glutamate.
Topics: Animals; Benzamides; Corticosterone; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Eating; Fasting; GABA-A Receptor Agonists; Glutamic Acid; Hyperphagia; Male; Muscimol; Paraventricular Hypothalamic Nucleus; Piperazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D4; Satiation; Tritium | 2014 |
L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Levodopa; Oxidopamine; Parkinsonian Disorders; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity | 2015 |
D4 dopamine receptor-specific antagonist improves reversal learning impairment in amphetamine-treated male rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Cues; Dopamine Antagonists; Dose-Response Relationship, Drug; Executive Function; Learning Disabilities; Male; Molecular Targeted Therapy; Nootropic Agents; Pyridines; Pyrroles; Rats, Long-Evans; Receptors, Dopamine D4; Reversal Learning; Reward; Severity of Illness Index | 2014 |
Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Light; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retinal Ganglion Cells; Retinitis Pigmentosa; Salicylamides; Sulpiride | 2015 |
Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior.
Topics: Animals; Anxiety; Avoidance Learning; Dopamine Antagonists; Fear; GABAergic Neurons; Male; Odorants; Prefrontal Cortex; Pyramidal Cells; Pyridines; Pyrroles; Rats, Sprague-Dawley; Receptors, Dopamine D4 | 2017 |
Dopamine D
Topics: Animals; Antipsychotic Agents; Benzamides; Clozapine; Cognitive Dysfunction; Female; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D4; Schizophrenia; Serotonin 5-HT1 Receptor Agonists | 2017 |
Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Dopamine; Humans; Ligands; Mice; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Structure, Secondary; Pyridines; Pyrroles; Receptors, Dopamine D4; Structure-Activity Relationship | 2019 |
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats.
Topics: Alcoholism; Animals; Behavior, Animal; Benzamides; Conditioning, Operant; Cues; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug-Seeking Behavior; Ethanol; Extinction, Psychological; Humans; Male; Piperazines; Pyridines; Pyrroles; Rats; Receptors, Dopamine D4; Self Administration; Stress, Psychological | 2020 |
Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response.
Topics: Amphetamine-Related Disorders; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Sensitization; Clozapine; Disease Models, Animal; Dopamine Agents; Locomotion; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Psychotic Disorders; Pyridines; Pyrroles; Receptors, Dopamine D4 | 2021 |
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
Topics: Alleles; Aminocaproic Acid; Complement Factor H; Drug Evaluation, Preclinical; Humans; Induced Pluripotent Stem Cells; Macular Degeneration; Models, Biological; Phenotype; Pyridines; Pyrroles; Retinal Pigment Epithelium | 2021 |