Page last updated: 2024-08-18

pyrroles and l 745870

pyrroles has been researched along with l 745870 in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	17 (26.15)	18.2507
2000's	28 (43.08)	29.6817
2010's	17 (26.15)	24.3611
2020's	3 (4.62)	2.80

Authors

Authors	Studies
Baker, R; Broughton, HB; Curtis, NR; Emms, F; Freedman, SB; Kulagowski, JJ; Leeson, PD; Marwood, R; Mawer, IM; Patel, S; Ragan, CI; Ridgill, MP	1
Audinot-Bouchez, V; Gobert, A; Millan, MJ; Newman-Tancredi, A	1
Chavez-Eng, CM; Constanzer, ML; Matuszewski, BK	1
Bristow, LJ; Kramer, MS; Kulagowski, J; Patel, S; Ragan, CI; Seabrook, GR	1
Capiris, T; Connor, DT; Heffner, TG; MacKenzie, RG; Miller, SR; Pugsley, TA; Unangst, PC; Wise, LD	1
Baskin, E; Bristow, LJ; Chapman, KL; Curtis, N; Emms, F; Fletcher, AE; Freedman, S; Graham, M; Knowles, M; Kulagowski, JJ; Leeson, PD; Lynch, JJ; Marwood, R; Matheson, S; Mcallister, G; Myers, J; Patel, S; Ragan, CI; Rathbone, D; Ridgill, M; Rupniak, NM; Watt, AP	1
Cao, BJ; Rodgers, RJ	1
Bristow, LJ; Collinson, N; Cook, GP; Curtis, N; Freedman, SB; Kulagowski, JJ; Leeson, PD; Patel, S; Ragan, CI; Ridgill, M; Saywell, KL; Tricklebank, MD	1
Brooks, EW; Mansbach, RS; Sanner, MA; Zorn, SH	1
Costanza, RM; Terry, P	1
Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M	1
Audinot, V; Brocco, M; Dekeyne, A; Gobert, A; Lejeune, F; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Peglion, JL; Rivet, JM; Schreiber, R; Spedding, M	1
Brown, NA; McAllister, G; Milligan, G; Pillai, G; Seabrook, GR	1
Gmeiner, P; Hübner, H; Löber, S	1
Chari, S; Deth, RC; DuRand, CJ; Kotb, M; Kramer, ML; Liu, D; Nagata, M; Ouellette, D; Sharma, A; Shim, S; Tan, W; Wick, PF	1
Bobirnac, I; Danzeisen, M; Gazi, L; Hoyer, D; Langenegger, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M	1
Chaki, S; Kawashima, N; Okuyama, S; Omura, T; Tomisawa, K	1
Clifford, JJ; Waddington, JL	1
Baillie, TA; Davis, MR; Doss, G; Kari, PH; Vyas, KP; Zhang, KE	1
De La Garza, R; Madras, BK	1
Henry, BL; LaHoste, GJ; Marshall, JF	1
Berardi, F; Chou, Y; Farde, L; Halldin, C; Langer, O; Leopoldo, M; Någren, K; Perrone, R; Sandell, J; Swahn, C	1
Gmeiner, P; Lanig, H; Utz, W	1
Bae, S; Huang, Y; Hwang, D; Kegeles, LS; Laruelle, M; Roth, BL; Savage, JE	1
Nadelhaft, I; Vera, PL	1
Berezińska, M; Nowak, JZ; Rosiak, J; Zawilska, JB	1
Chapman, KL; Hutson, PH; Marston, D; Patel, S; Ragan, CI	1
Chaperon, F; Neijt, HC; Tricklebank, MD; Unger, L	1
Bernaerts, P; Tirelli, E	1
Andersen, SL; Baldessarini, RJ; Grady, CJ; Tarazi, FI; Tsapakis, EM; Zhang, K	1
Aceves, J; Erlij, D; Floran, B; Floran, L	1
Jardemark, K; Konradsson, A; Marcus, MM; Svensson, TH	1
Aceves, J; Gutiérrez, R; Romo-Parra, H	1
Mamiya, T; Matsumura, T; Ukai, M	1
Hadano, S; Ikeda, JE; Kohiki, E; Okada, Y; Osuga, H; Sakai, H; Suga, E; Tanaka, K; Yanagisawa, Y	1
Brioni, JD; Chang, R; Cowart, MD; Donnelly-Roberts, DL; Hsieh, GC; Marsh, K; Miller, L; Miller, TR; Moreland, RB; Nakane, M; Namovic, MT; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM	1
Mitsunaga, H; Ukai, M	1
Allouchi, H; Argiolas, A; El Hakmaoui, A; Enguehard-Gueiffier, C; Gmeiner, P; Gueiffier, A; Hübner, H; Melis, MR	1
Aceves, J; Anaya, V; Bargas, J; Galarraga, E; Hernández, A; Ibáñez-Sandoval, O; Sierra, A; Tapia, D; Valdiosera, R	1
Argiolas, A; Enguehard-Gueiffier, C; Gmeiner, P; Gueiffier, A; Hubner, H; Mascia, MS; Melis, MR; Melis, T; Sanna, F; Succu, S	1
Argiolas, A; Boi, A; Melis, MR; Melis, T; Sanna, F; Succu, S	1
Agnati, L; De La Calle, A; Fuxe, K; Gago, B; Peñafiel, A; Rivera, A	1
Aoki, M; Hadano, S; Ikeda, JE; Itoyama, Y; Kanno, T; Kohiki, E; Okada, Y; Onoe, K; Osuga, H; Otomo, A; Shouguchi-Miyata, J; Suga, E; Tanaka, K; Yanagisawa, Y	1
Floresco, SB; St Onge, JR	1
Braszko, JJ	1
Fan, X; Hess, EJ; Xu, M	1
Arai, Y; Kikuchi, T; Mitazaki, S; Nakagawasai, O; Nakaya, K; Niijima, F; Onogi, H; Sato, A; Tadano, T; Tan-No, K	1
Agnati, LF; Brené, S; de la Calle, A; Fuxe, K; Gago, B; Reina-Sánchez, MD; Rivera, A; Rodríguez-Pérez, LM; Suárez-Boomgaard, D	1
Barnes, C; Gamaleddin, I; Goldberg, SR; Justinova, Z; Le Foll, B; Le Strat, Y; Pushparaj, A; Yan, Y	1
Aman, A; Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Koprich, JB	1
Andersson, RH; Buonanno, A; Fisahn, A; Herman, PA; Johnston, A; Karavanova, I; Vullhorst, D; Winzer-Serhan, UH	1
Argiolas, A; Corda, MG; Giorgi, O; Gmeiner, P; Hübner, H; Löber, S; Melis, MR; Piludu, MA; Sanna, F	1
Cocker, PJ; Le Foll, B; Rogers, RD; Winstanley, CA	1
Ikeda, K; Ikejiri, M; Ishiyama, T; Murai, T; Nakako, T; Taiji, M	1
Di Ciano, P; Grandy, DK; Le Foll, B	1
Cruz-Martínez, AM; Escartín-Pérez, RE; Florán-Garduño, B; García-Iglesias, B; López-Alonso, VE; Mancilla-Díaz, JM; Tejas-Juárez, JG	1
Brotchie, JM; Espinosa, MC; Fox, SH; Huot, P; Johnston, TH; Koprich, JB; Reyes, MG	1
Connolly, NP; Gomez-Serrano, M	1
Jensen, R	1
Fuentealba, JA; Gysling, K; Keller, VN; Vergara, MD	1
Meltzer, HY; Miyauchi, M; Neugebauer, NM	1
Cao, C; He, L; Wang, X; Zhang, XC; Zhou, Y	1
Di Ciano, P; Kim, A; Le Foll, B; Leca, J; Pushparaj, A	1
Chen, JC; Liao, IM	1
Amaral, J; Bharti, K; Bose, D; Campos, MM; Chang, J; Dejene, R; Ferrer, M; George, A; Hanson, E; Jha, BS; Karla, BS; King, R; Lal, M; Liang, G; McGaughey, D; Memon, O; Miyagishima, KJ; Nimmagadda, M; Ortolan, D; Qureshy, Z; Rising, A; Sharma, R; Wan, Q	1

Reviews

2 review(s) available for pyrroles and l 745870

Article	Year
Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends in pharmacological sciences, 1997, Volume: 18, Issue:6 Topics: Animals; Antipsychotic Agents; Biological Availability; Clinical Trials as Topic; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4; Rodentia; Schizophrenia	1997
Dopamine D4 receptors in psychostimulant addiction. Advances in pharmacology (San Diego, Calif.), 2014, Volume: 69 Topics: Animals; Central Nervous System Stimulants; Cocaine-Related Disorders; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4; Substance-Related Disorders	2014

Other Studies

63 other study(ies) available for pyrroles and l 745870

Article	Year
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. Journal of medicinal chemistry, 1996, May-10, Volume: 39, Issue:10 Topics: Animals; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4	1996
Noradrenaline and adrenaline are high affinity agonists at dopamine D4 receptors. European journal of pharmacology, 1997, Jan-29, Volume: 319, Issue:2-3 Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agonists; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Norepinephrine; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Sulfur Radioisotopes; Thermodynamics	1997
Picogram determination of a novel dopamine D4 receptor antagonist in human plasma and urine by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-28, Volume: 691, Issue:1 Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Dopamine D2 Receptor Antagonists; Humans; Mass Spectrometry; Microchemistry; Pyridines; Pyrroles; Receptors, Dopamine D4; Sensitivity and Specificity	1997
Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents. Journal of medicinal chemistry, 1997, Aug-15, Volume: 40, Issue:17 Topics: Animals; Antipsychotic Agents; CHO Cells; Cloning, Molecular; Cricetinae; Dopamine D2 Receptor Antagonists; Humans; Kinetics; Levodopa; Models, Chemical; Piperazines; Pyridines; Pyridones; Pyrroles; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship; Sulfonamides	1997
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Phenazocine; Prolactin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Saimiri	1997
Dopamine D4 receptor and anxiety: behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze. European journal of pharmacology, 1997, Sep-24, Volume: 335, Issue:2-3 Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Isoxazoles; Male; Maze Learning; Mice; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D4	1997
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3 Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Mice; Motor Activity; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D4	1997
Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition. Psychopharmacology, 1998, Volume: 135, Issue:2 Topics: Animals; Apomorphine; Cell Line; Dopamine Antagonists; Humans; Male; Piperazines; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Reflex, Startle; Sulfonamides	1998
The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline. European journal of pharmacology, 1998, Mar-19, Volume: 345, Issue:2 Topics: Animals; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Antagonists; Male; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4	1998
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. British journal of pharmacology, 1998, Volume: 124, Issue:5 Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone	1998
S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H- The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1 Topics: Animals; Basal Ganglia Diseases; Body Temperature; Brain; Dioxins; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperazines; Pyridines; Pyrroles; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D4; Receptors, sigma; Salicylamides; Serotonin	1998
Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively. Neuropharmacology, 1998, Volume: 37, Issue:8 Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Indoles; Ion Channel Gating; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyridines; Pyrroles; Receptors, Dopamine D4	1998
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps. Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1 Topics: Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Indoles; Isomerism; Kinetics; Models, Chemical; Pyrazoles; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Static Electricity; Structure-Activity Relationship; Surface Properties	1999
D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Molecular psychiatry, 1999, Volume: 4, Issue:3 Topics: Amino Acid Sequence; Aminopyridines; Animals; Benzazepines; Binding Sites; Carbon Radioisotopes; CHO Cells; Clozapine; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Formates; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Methionine; Mutagenesis, Site-Directed; Neuroblastoma; Phospholipids; Phosphorylation; Piperidines; Psychotic Disorders; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; S-Adenosylmethionine; Salicylamides; Schizophrenia; Transfection; Tumor Cells, Cultured	1999
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells. British journal of pharmacology, 1999, Volume: 128, Issue:3 Topics: Aminopyridines; Animals; Butyrates; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agents; Humans; Ligands; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Spiperone	1999
Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats. Life sciences, 1999, Volume: 65, Issue:24 Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Neurons; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Substantia Nigra; Thiazoles; Ventral Tegmental Area	1999
Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 22, Issue:5 Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Habituation, Psychophysiologic; Male; Psychotic Disorders; Pyrazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4	2000
Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:6 Topics: Acetylcysteine; Animals; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Macaca mulatta; Male; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4	2000
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse (New York, N.Y.), 2000, Sep-01, Volume: 37, Issue:3 Topics: Aminopyridines; Animals; Autoradiography; Brain; Hippocampus; Macaca mulatta; Molecular Probes; Piperidines; Prefrontal Cortex; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tritium	2000
Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17 Topics: Action Potentials; Amphetamine; Animals; Corpus Striatum; Dopamine Antagonists; Genes, fos; Indans; Indoles; Male; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrodotoxin	2000
Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography. Nuclear medicine and biology, 2000, Volume: 27, Issue:8 Topics: Animals; Benzamides; Brain; Female; Injections, Intravenous; Isotope Labeling; Ligands; Macaca fascicularis; Piperazines; Pyridines; Pyrroles; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Dopamine D4; Tissue Distribution; Tomography, Emission-Computed	2000
Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapi Journal of medicinal chemistry, 2001, Apr-12, Volume: 44, Issue:8 Topics: Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Models, Molecular; Pyrazoles; Pyridines; Pyrroles; Receptors, Dopamine D4	2001
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. Bioorganic & medicinal chemistry letters, 2001, Jun-04, Volume: 11, Issue:11 Topics: Binding Sites; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Tomography, Emission-Computed	2001
Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats. Neurourology and urodynamics, 2001, Volume: 20, Issue:5 Topics: Anesthesia; Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Female; Haloperidol; Hypogastric Plexus; Pyridines; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Urinary Bladder; Urination; Urination Disorders	2001
L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:3 Topics: Animals; Arylamine N-Acetyltransferase; Chickens; Circadian Rhythm; Darkness; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Male; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Serotonin	2003
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. Neuropharmacology, 2003, Volume: 44, Issue:8 Topics: Animals; Binding Sites; Cyclic AMP; Darkness; Dopamine Agonists; Dopamine Antagonists; In Vitro Techniques; Indoles; Male; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Spiperone	2003
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. Neuropharmacology, 2003, Volume: 44, Issue:8 Topics: Animals; Aporphines; Benzazepines; Benzopyrans; Body Temperature Regulation; Dopamine Agonists; Dopamine Antagonists; Hypothermia; Indoles; Oxazines; Piperazines; Piperidines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4	2003
Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice. Behavioural brain research, 2003, Jun-16, Volume: 142, Issue:1-2 Topics: Analysis of Variance; Animals; Avoidance Learning; Benzamides; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Inhibition, Psychological; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperazines; Pyridines; Pyrroles; Reaction Time; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4	2003
Regulation of working memory by dopamine D4 receptor in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:9 Topics: Animals; Attention; Conditioning, Operant; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Memory, Short-Term; Psychomotor Performance; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4	2004
Dopamine D4 receptors inhibit depolarization-induced [3H]GABA release in the rat subthalamic nucleus. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: Animals; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Methamphetamine; Methylphenidate; Potassium; Pyridines; Pyrroles; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Subthalamic Nucleus; Sulpiride; Tritium	2004
The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex. The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:2 Topics: Analysis of Variance; Animals; Dopamine Antagonists; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; N-Methylaspartate; Nicotine; Prefrontal Cortex; Pyramidal Cells; Pyridines; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2005
Tonic modulation of inhibition by dopamine D4 receptors in the rat hippocampus. Hippocampus, 2005, Volume: 15, Issue:2 Topics: Animals; Clozapine; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; GABA Antagonists; Hippocampus; Male; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Perforant Pathway; Pyridines; Pyrroles; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Synapses	2005
Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. Annals of the New York Academy of Sciences, 2004, Volume: 1025 Topics: Animals; Cyclic AMP; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Mice; Morphine Dependence; Naloxone; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Substance Withdrawal Syndrome	2004
A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:7 Topics: Animals; Apoptosis; Cell Line; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Gerbillinae; Hippocampus; Humans; Ischemia; Male; Nerve Tissue Proteins; Neuronal Apoptosis-Inhibitory Protein; Neurons; Oxidative Stress; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D4; Up-Regulation; Vitamin K 3	2005
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology, 2005, Volume: 49, Issue:1 Topics: Animals; Benzamides; Benzimidazoles; Binding, Competitive; Calcium; Cell Line; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Europium; Fluorometry; GABA Antagonists; Guanosine Triphosphate; Humans; Male; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spiperone; Time Factors; Tritium	2005
Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat. Methods and findings in experimental and clinical pharmacology, 2005, Volume: 27, Issue:9 Topics: Animals; Biphenyl Compounds; Bromocriptine; Cocaine; Discrimination, Psychological; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Inbred F344; Receptors, Dopamine D3; Receptors, Dopamine D4; Tetrahydronaphthalenes	2005
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: Animals; Cattle; CHO Cells; Cricetinae; Cricetulus; Erectile Dysfunction; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Ligands; Male; Mitosis; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Receptors, Dopamine D4; Structure-Activity Relationship	2006
Control of the subthalamic innervation of the rat globus pallidus by D2/3 and D4 dopamine receptors. Journal of neurophysiology, 2006, Volume: 96, Issue:6 Topics: Algorithms; Animals; Benzamides; Dopamine; Dopamine Agonists; Electric Stimulation; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Histocytochemistry; In Vitro Techniques; Neural Pathways; Patch-Clamp Techniques; Piperazines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Subthalamus; Synapses	2006
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. The European journal of neuroscience, 2006, Volume: 24, Issue:7 Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Brain; Calcium Channel Blockers; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Routes; Imidazoles; Male; Nitrates; Nitric Oxide; Nitrites; omega-Conotoxins; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4	2006
Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin. Neuropharmacology, 2007, Volume: 52, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzamides; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Electrochemistry; Male; Microinjections; Nucleus Accumbens; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine	2007
Dopamine D(4) receptor activation decreases the expression of mu-opioid receptors in the rat striatum. The Journal of comparative neurology, 2007, May-20, Volume: 502, Issue:3 Topics: Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Receptors, Opioid, mu; Time Factors	2007
A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Experimental neurology, 2008, Volume: 211, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Movement; Disease Models, Animal; Disease Progression; Dopamine Antagonists; Female; Humans; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyridines; Pyrroles; Spinal Cord	2008
Dopaminergic modulation of risk-based decision making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:3 Topics: Animals; Behavior, Animal; Benzamides; Benzazepines; Benzopyrans; Bromocriptine; Conditioning, Operant; Decision Making; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Naphthalenes; Oxazines; Piperazines; Pyridines; Pyrroles; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Reinforcement Schedule; Risk; Salicylamides	2009
Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:2 Topics: Angiotensin II; Animals; Anxiety; Avoidance Learning; Cognition; Data Interpretation, Statistical; Dopamine Antagonists; Exploratory Behavior; Form Perception; Injections, Intraventricular; Male; Maze Learning; Mental Recall; Motor Activity; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D4; Recognition, Psychology	2009
D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. Neurobiology of disease, 2010, Volume: 37, Issue:1 Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Benzopyrans; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Space; Indoles; Locomotion; Mice; Mice, Knockout; Mice, Mutant Strains; Piperidines; Pyridines; Pyrroles; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4	2010
p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission. Behavioural brain research, 2010, Dec-25, Volume: 214, Issue:2 Topics: Animals; Benzazepines; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Oxidopamine; p-Hydroxyamphetamine; Piperazines; Piperidines; Pyridines; Pyrroles; Reflex, Startle; Salicylamides; Sensory Gating; Sympathomimetics; Synaptic Transmission	2010
Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation. Brain research, 2011, Aug-17, Volume: 1407 Topics: Analgesics, Opioid; Animals; Autoradiography; Benzamides; Caudate Nucleus; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dopamine Antagonists; Genes, fos; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Piperazines; Proto-Oncogene Proteins c-fos; Putamen; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Transcription Factors	2011
Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:3 Topics: Animals; Behavior, Animal; Discrimination Learning; Dopamine Antagonists; Drug-Seeking Behavior; Extinction, Psychological; Male; Nicotine; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Dopamine D4; Reinforcement, Psychology; Self Administration	2012
L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Brain; Drug Interactions; Dyskinesias; Female; Levodopa; Macaca; Male; Motor Activity; Parkinson Disease; Pyridines; Pyrroles; Receptors, Dopamine D4	2012
Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors. Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-07, Volume: 109, Issue:32 Topics: Animals; Brain Waves; Dopamine; Fluorescent Antibody Technique; Fourier Analysis; Hippocampus; Immunohistochemistry; In Situ Hybridization; Interneurons; Neuregulins; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction	2012
Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats. Pharmacology, biochemistry, and behavior, 2013, Volume: 109 Topics: Animals; Avoidance Learning; Benzamides; Dopamine Agonists; Penile Erection; Piperazines; Pyrazoles; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity; Yawning	2013
A selective role for dopamine D₄ receptors in modulating reward expectancy in a rodent slot machine task. Biological psychiatry, 2014, May-15, Volume: 75, Issue:10 Topics: Animals; Benzamides; Dopamine Agonists; Dopamine Antagonists; Male; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Dopamine D4; Reward; Risk-Taking	2014
Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone. Behavioural brain research, 2014, Mar-15, Volume: 261 Topics: Animals; Antipsychotic Agents; Callithrix; Cognition; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Female; Isoindoles; Lurasidone Hydrochloride; Male; Mental Recall; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Receptors, Dopamine D4; Thiazoles	2014
Stimulation of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus of male rats induces hyperphagia: involvement of glutamate. Physiology & behavior, 2014, Jun-22, Volume: 133 Topics: Animals; Benzamides; Corticosterone; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Eating; Fasting; GABA-A Receptor Agonists; Glutamic Acid; Hyperphagia; Male; Muscimol; Paraventricular Hypothalamic Nucleus; Piperazines; Pyridines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D4; Satiation; Tritium	2014
L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat. Behavioural pharmacology, 2015, Volume: 26, Issue:1-2 Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Levodopa; Oxidopamine; Parkinsonian Disorders; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Species Specificity	2015
D4 dopamine receptor-specific antagonist improves reversal learning impairment in amphetamine-treated male rats. Experimental and clinical psychopharmacology, 2014, Volume: 22, Issue:6 Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Cues; Dopamine Antagonists; Dose-Response Relationship, Drug; Executive Function; Learning Disabilities; Male; Molecular Targeted Therapy; Nootropic Agents; Pyridines; Pyrroles; Rats, Long-Evans; Receptors, Dopamine D4; Reversal Learning; Reward; Severity of Illness Index	2014
Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PloS one, 2015, Volume: 10, Issue:12 Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Light; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retinal Ganglion Cells; Retinitis Pigmentosa; Salicylamides; Sulpiride	2015
Activation of type 4 dopaminergic receptors in the prelimbic area of medial prefrontal cortex is necessary for the expression of innate fear behavior. Behavioural brain research, 2017, 05-01, Volume: 324 Topics: Animals; Anxiety; Avoidance Learning; Dopamine Antagonists; Fear; GABAergic Neurons; Male; Odorants; Prefrontal Cortex; Pyramidal Cells; Pyridines; Pyrroles; Rats, Sprague-Dawley; Receptors, Dopamine D4	2017
Dopamine D Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:4 Topics: Animals; Antipsychotic Agents; Benzamides; Clozapine; Cognitive Dysfunction; Female; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Pyridines; Pyrroles; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D4; Schizophrenia; Serotonin 5-HT1 Receptor Agonists	2017
Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. eLife, 2019, 11-21, Volume: 8 Topics: Animals; Binding Sites; Crystallography, X-Ray; Dopamine; Humans; Ligands; Mice; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Structure, Secondary; Pyridines; Pyrroles; Receptors, Dopamine D4; Structure-Activity Relationship	2019
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats. European journal of pharmacology, 2020, Jan-15, Volume: 867 Topics: Alcoholism; Animals; Behavior, Animal; Benzamides; Conditioning, Operant; Cues; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug-Seeking Behavior; Ethanol; Extinction, Psychological; Humans; Male; Piperazines; Pyridines; Pyrroles; Rats; Receptors, Dopamine D4; Self Administration; Stress, Psychological	2020
Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response. Behavioural brain research, 2021, 01-01, Volume: 396 Topics: Amphetamine-Related Disorders; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Sensitization; Clozapine; Disease Models, Animal; Dopamine Agents; Locomotion; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Psychotic Disorders; Pyridines; Pyrroles; Receptors, Dopamine D4	2021
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nature communications, 2021, 12-15, Volume: 12, Issue:1 Topics: Alleles; Aminocaproic Acid; Complement Factor H; Drug Evaluation, Preclinical; Humans; Induced Pluripotent Stem Cells; Macular Degeneration; Models, Biological; Phenotype; Pyridines; Pyrroles; Retinal Pigment Epithelium	2021

chemdatabank.com

pyrroles and l 745870

Research

Studies (65)

Authors

Reviews

Other Studies