pyrroles has been researched along with l 731988 in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blau, C; Espeseth, A; Felock, P; Gabryelski, L; Grobler, JA; Hazuda, DJ; Miller, MD; Schleif, W; Stillmock, K; Witmer, M; Wolfe, A | 1 |
| Anthony, N; Cole, JL; Egbertson, M; Espeseth, AS; Felock, P; Grobler, J; Hamill, T; Hazuda, DJ; Melamed, JY; Witmer, M; Wolfe, A; Young, S | 1 |
| Keserû, GM; Kolossváry, I | 1 |
| Lee, DJ; Reinke, R; Robinson, WE | 1 |
| Beale, K; King, PJ; Lee, DJ; Reinke, RA; Robinson, WE; Victoria, JG | 1 |
| Johnson, AA; Marchand, C; Pommier, Y | 1 |
| King, PJ; Lee, DJ; Lei, X; Mao, Y; McDougall, BR; Reinecke, MG; Reinke, RA; Robinson, WE; Victoria, J | 1 |
| Grant, GH; Huang, M; Richards, WG | 1 |
| Chen, JM; Chen, X; Hung, M; Jin, H; Jones, GS; Kim, CU; Qi, X; Swaminathan, S; Tsiang, M; Yu, F; Zeynalzadegan, A | 1 |
| Barreca, ML; Chimirri, A; De Luca, L; Iraci, N | 1 |
1 review(s) available for pyrroles and l 731988
| Article | Year |
|---|---|
HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial.
Topics: Acetoacetates; Anti-HIV Agents; Biological Factors; Caffeic Acids; Clinical Trials as Topic; Furans; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Indoles; Models, Molecular; Molecular Structure; Oligonucleotides; Pyrroles; Reverse Transcriptase Inhibitors; Succinates; Tetrazoles; Triazoles | 2004 |
9 other study(ies) available for pyrroles and l 731988
| Article | Year |
|---|---|
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
Topics: Acetoacetates; Anti-HIV Agents; Catalysis; Coculture Techniques; DNA, Circular; DNA, Viral; Drug Resistance, Microbial; HIV Integrase; HIV Integrase Inhibitors; HIV Long Terminal Repeat; HIV-1; Humans; Mutation; Pyrroles; Recombinant Proteins; T-Lymphocytes; Transcription, Genetic; Tumor Cells, Cultured; Virus Integration; Virus Replication | 2000 |
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Topics: Acetoacetates; Base Sequence; Catalysis; DNA Primers; DNA, Viral; Epitopes; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Pyrroles; Substrate Specificity | 2000 |
Fully flexible low-mode docking: application to induced fit in HIV integrase.
Topics: Acetoacetates; Algorithms; Binding Sites; Catalytic Domain; HIV Integrase; HIV Integrase Inhibitors; Models, Molecular; Protein Conformation; Pyrroles; Thermodynamics | 2001 |
Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
Topics: Acetoacetates; Cell Line; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Molecular Sequence Data; Pyrroles; Sequence Analysis, DNA; Virus Replication | 2002 |
Human immunodeficiency virus type-1 integrase containing a glycine to serine mutation at position 140 is attenuated for catalysis and resistant to integrase inhibitors.
Topics: Acetoacetates; Amino Acid Substitution; Caffeic Acids; Cell Line; Drug Resistance, Viral; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Succinates; Virus Integration; Virus Replication | 2003 |
L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.
Topics: Acetoacetates; Binding Sites; Caffeic Acids; Cell Line, Tumor; Dose-Response Relationship, Drug; Echinacea; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Kinetics; Mutation; Polymerase Chain Reaction; Pyrroles; Succinates; Virus Integration | 2004 |
Diketoacid HIV-1 integrase inhibitors: An ab initio study.
Topics: Acetoacetates; Algorithms; HIV Integrase Inhibitors; Indoles; Molecular Structure; Pyrroles; Quantum Theory; Tetrazoles | 2005 |
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
Topics: Acetoacetates; Binding Sites; Crystallography, X-Ray; DNA, Viral; Furans; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Hydrophobic and Hydrophilic Interactions; Magnesium; Models, Chemical; Models, Molecular; Mutation; Naphthyridines; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrroles; Reproducibility of Results; Triazoles | 2008 |
Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.
Topics: Acetoacetates; Anti-HIV Agents; Binding Sites; Computer Simulation; Drug Design; Furans; HIV Integrase; HIV Integrase Inhibitors; Humans; Mutation; Naphthyridines; Pyrroles; Pyrrolidinones; Quinolones; Raltegravir Potassium; Triazoles | 2009 |