pyrroles has been researched along with guanine in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (10.00) | 18.7374 |
| 1990's | 9 (15.00) | 18.2507 |
| 2000's | 21 (35.00) | 29.6817 |
| 2010's | 21 (35.00) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsiung, GD; Klein, S; Yang, ZH | 1 |
| Hsiung, GD; Hu, JM | 1 |
| Fontenelle, LJ; Henderson, JF; Smith, CM; Snyder, FF | 1 |
| Frank-Kamenetskii, MD; Ivanov, VI; Minchenkova, LE; Minyat, EE; Schyolkina, AK | 1 |
| Baker, BR; Siebeneick, HU | 1 |
| Suhadolnik, RJ; Uematsu, T | 1 |
| Rajalakshmi, S; Rao, RM; Sarma, DS | 1 |
| Garcia, GA; Hoops, GC; Townsend, LB | 1 |
| Allen, M; Ananthan, S; Babu, YS; Bugg, CE; Ealick, SE; Erion, MD; Guida, WC; Niwas, S; Rose, JD; Secrist, JA | 1 |
| Taylor, EC | 1 |
| Ficner, R; Reuter, K; Romier, C; Suck, D | 1 |
| Amosova, O; Fresco, JR; George, J | 1 |
| Ahn, HS; Bercovici, A; Boykow, G; Bronnenkant, A; Chackalamannil, S; Chow, J; Cleven, R; Cook, J; Czarniecki, M; Domalski, C; Fawzi, A; Green, M; Gündes, A; Ho, G; Laudicina, M; Lindo, N; Ma, K; Manna, M; McKittrick, B; Mirzai, B; Nechuta, T; Neustadt, B; Puchalski, C; Pula, K; Zhang, H | 1 |
| Leonard, P; Melenewski, A; Seela, F; Wei, C | 1 |
| Bergstrom, DE; Glass, GA; Hua, P; Kinsey, BM; Klysik, J; Orson, FM; Ward, B | 1 |
| Ficner, R; Garcia, GA; Gerber, HD; Goodenough-Lashua, DM; Grädler, U; Klebe, G; Reuter, K; Stubbs, MT | 1 |
| Elzein, E; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF; Vidwans, A | 1 |
| Berger, NA; Berger, SJ; Dowlati, A; Gerson, SL; Haaga, J; Liu, L; Remick, SC; Spiro, TP; Willson, JK | 1 |
| Honsho, A; Ide, H; Makino, K; Masaoka, A; Ohyama, Y; Suzuki, T; Terato, H; Yamada, M | 1 |
| Aronov, PA; Green, PG; Ngo, M; Patterson, TJ; Reznikova, TV; Rice, RH | 1 |
| Liu, B; Taylor, EC | 1 |
| Cox, KK; Hartley, JA; Lacy, ER; Le, M; Lee, M; Nguyen, B; OHare, C; Wilson, WD | 1 |
| Abdollahi, A; Bischof, M; Debus, JU; Gong, P; Huber, PE; Lipson, KE; Stoffregen, C; Weber, KJ | 1 |
| Basso, LA; Canduri, F; de Azevedo, WF; dos Santos, DM; Palma, MS; Santos, DS; Silva, RG | 1 |
| Potaczek, DP; Szczeklik, A; Undas, A | 1 |
| Baker, ES; Bowers, MT; Lee, JT; Sessler, JL | 1 |
| Brown, S; de Crécy-Lagard, V; Iwata-Reuyl, D; Lee, B; Reddy, RR; Schimmel, P; Swairjo, MA; Van Lanen, SG | 1 |
| Adams, H; Aiertza, MK; Burrell, AJ; Edmont, D; Hammond, DM; Hornillo-Araujo, AR; Margison, GP; Shibata, T; Williams, DM | 1 |
| Bruice, TC; Canzio, D; Correa, BJ; Kahane, AL; Reddy, PM | 1 |
| Fang, JM; Lu, SH; Selvi, S | 1 |
| Yuan, G; Zhou, J | 1 |
| Brown, T; Fox, KR; Gerrard, SR; Srinivasan, N | 1 |
| Hudson, RH; Wojciechowski, F | 1 |
| Bag, SS; Matsumoto, K; Saito, I; Saito, Y; Shinohara, Y; Takeuchi, Y | 1 |
| Brodbelt, JS; Jayawickramarajah, J; Lawrence, CM; Pierce, SE; Sessler, JL; Sherman, CL | 1 |
| Keel, K; Laíz, J; Tosar, JP | 1 |
| Fumita, S; Hashimoto, J; Ichikawa, Y; Kimura, N; Miyazaki, M; Nakagawa, K; Ohki, E; Okamoto, I; Shimizu, T; Takeda, M; Terashima, M; Tsurutani, J | 1 |
| Brooks, AF; Chen, YC; Garcia, GA; Goodenough-Lashua, DM; Kittendorf, JD; Showalter, HD | 1 |
| Bathaie, SZ; Kazemi, SH; Mousavi, MF; Yousef Elahi, M | 1 |
| Harbord, N | 1 |
| Blais, N; Camidge, DR; Canil, C; Chao, RC; Chow, LQ; Diab, SG; Jonker, DJ; Laurie, SA; McWilliam, M; Ruiz-Garcia, A; Thall, A; Tye, L; Zhang, K | 1 |
| Budow, S; Ding, P; Leonard, P; Ming, X; Seela, F | 1 |
| Brooks, AF; Garcia, GA; Showalter, HD; Vélez-Martínez, CS | 1 |
| Gerber, HD; Klebe, G | 1 |
| Blais, N; Camidge, DR; Chao, RC; Chow, LQ; Doebele, RC; Jonker, DJ; Laurie, SA; Ruiz-Garcia, A; Soulières, D; Thall, A; Zhang, K | 1 |
| Bahleda, R; Escudier, B; Gueutin, V; Izzedine, H; Rouvier, P; Soria, JC; Varga, A | 1 |
| Blais, N; Camidge, DR; Chao, RC; Chow, LQ; Diab, SG; Jonker, DJ; Laurie, SA; Ruiz-Garcia, A; Soulières, D; Thall, A; Zhang, K | 1 |
| Karadas, N; Ozkan, SA | 1 |
| Gandhi, L; Heist, RS; Hodgson, L; Otterson, GA; Socinski, MA; Stinchcombe, TE; Villalona-Calero, MA; Vokes, EE; Wang, X; Watson, P | 1 |
| Gao, YS; Lu, LM; Nie, T; Wu, LP; Wu, Y; Xu, JK; Zhang, KX; Zhu, XF | 1 |
| de Mayolo, JA; Edelman, MJ; Evans, TL; Feliciano, J; Fidler, MJ; Keresztes, R; Medeiros, M; Otterson, G; Rogers, JS; Sanborn, RE; Schneider, BJ; Sequist, LV; Tan, MT; Yang, Y; Zaknoen, SL | 1 |
| Jackson, PJ; Karu, K; Mantaj, J; Rahman, KM; Thurston, DE | 1 |
| Ayele, T; Choi, YJ; Deventer, KV; Gibala, KS; Resendiz, MJE | 1 |
| Basher, MA; Fox, KR; Jackson, PJM; Rahman, KM; Thurston, DE | 1 |
| Asamitsu, S; Bando, T; Hashiya, K; Obata, S; Phan, AT; Sugiyama, H | 1 |
| Bull, GD; Thompson, KC | 1 |
| Balamkundu, S; Carstens, AB; Cui, L; de Crécy-Lagard, V; Dedon, PC; Fa Lui, C; Gnanakalai, S; Hansen, LH; Hatfull, GF; Hillebrand, R; Hutinet, G; Jacobs-Sera, D; Kot, W; Lee, YJ; Moineau, S; Neelakandan, R; Sassanfar, M; Tremblay, D; Weigele, P | 1 |
| Chatterjee, S; Daher, M; Lund, PE; Walter, NG | 1 |
| Carstens, AB; Cui, L; de Crécy-Lagard, V; Dedon, PC; Hansen, LH; Hutinet, G; Kot, W; Moineau, S; Nielsen, TK; Olsen, NS; Swairjo, MA | 1 |
| Kondhare, D; Leonard, P; Seela, F; Zhang, A | 1 |
2 review(s) available for pyrroles and guanine
| Article | Year |
|---|---|
Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Drug Design; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Indicators and Reagents; Molecular Structure; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Pyrroles; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates | 1993 |
Novel nephrotoxins.
Topics: Adenine; Alcohols; Angiogenesis Inhibitors; Anticonvulsants; Antipsychotic Agents; Dasatinib; Diphosphonates; Glutamates; Guanine; HIV Protease Inhibitors; Humans; Indoles; Kidney Diseases; Organophosphonates; Oxalates; Pamidronate; Pemetrexed; Phenindione; Plants, Toxic; Proton Pump Inhibitors; Pyrimidines; Pyrroles; Selective Serotonin Reuptake Inhibitors; Sunitinib; Tenofovir; Thiazoles; Triazines | 2011 |
6 trial(s) available for pyrroles and guanine
| Article | Year |
|---|---|
Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors.
Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Feasibility Studies; Female; Glutamates; Guanine; Humans; Indoles; Japan; Male; Middle Aged; Neoplasms; Pemetrexed; Protein Kinase Inhibitors; Pyrroles; Sunitinib; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
A phase I dose-escalation and pharmacokinetic study of sunitinib in combination with pemetrexed in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Pemetrexed; Pyrroles; Sunitinib; Treatment Outcome | 2012 |
Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cohort Studies; Female; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Pemetrexed; Pyrroles; Sunitinib | 2013 |
Sunitinib combined with pemetrexed and carboplatin in patients with advanced solid malignancies--results of a phase I dose-escalation study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Glutamates; Guanine; Humans; Indoles; Leukopenia; Lung Neoplasms; Male; Maximum Tolerated Dose; Mesothelioma; Middle Aged; Pemetrexed; Pyrroles; Sunitinib; Young Adult | 2013 |
CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Prognosis; Pyrroles; Remission Induction; Salvage Therapy; Sunitinib; Survival Rate | 2014 |
Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 2; Disease-Free Survival; Docetaxel; Double-Blind Method; Drug Administration Schedule; Female; Glutamates; Guanine; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Patient Selection; Pemetrexed; Prostaglandins; Pyrroles; Sulfonamides; Taxoids; Treatment Outcome | 2015 |
52 other study(ies) available for pyrroles and guanine
| Article | Year |
|---|---|
Comparative effects of two acycleonucleoside derivatives on ultrastructure and replication of guinea pig cytomegalovirus in cultured cells.
Topics: Acyclovir; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Deoxyguanosine; Female; Guanine; Guinea Pigs; Morphogenesis; Organophosphorus Compounds; Pregnancy; Pyrimidines; Pyrroles; Virus Replication | 1991 |
Activities of two new antiviral agents against guinea pig lymphotropic herpesvirus infection in vitro.
Topics: Acyclovir; Animals; Antiviral Agents; Cells, Cultured; Guanine; Guinea Pigs; Herpesviridae; Organophosphorus Compounds; Pyrimidines; Pyrroles; Viral Plaque Assay | 1989 |
Improved methods for the study of drug effects on purine metabolism and their application to nebularine and 7-deazanebularine.
Topics: Adenine; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, DEAE-Cellulose; Diphosphates; Fibroblasts; Guanine; Hypoxanthines; Inosine; Kinetics; Nucleotides; Oxidoreductases; Purine Nucleosides; Purines; Pyrimidines; Pyrroles; Ribonucleosides; Stimulation, Chemical; Structure-Activity Relationship | 1974 |
The B to A transition of DNA in solution.
Topics: Animals; Anti-Bacterial Agents; Binding Sites; Calcium; Cattle; Cesium; Circular Dichroism; Cytosine; Dactinomycin; DNA; Ethanol; Guanidines; Guanine; Lithium; Magnesium; Models, Chemical; Nucleic Acid Conformation; Pyrroles; Sodium; Solutions; Temperature | 1974 |
Affinity chromatography of guanine deaminase and xanthine oxidase.
Topics: Aminohydrolases; Animals; Cattle; Chromatography, Affinity; Guanine; Ligands; Pyrimidines; Pyrroles; Rats; Sepharose; Xanthine Oxidase | 1974 |
Nucleoside antibiotics. VI. Biosynthesis of the pyrrolopyrimidine nucleoside antibiotic toyocamycin by Streptomyces rimosus.
Topics: Adenine; Anti-Bacterial Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Formates; Guanine; Nucleosides; Pyrimidines; Pyrroles; Streptomyces | 1970 |
Carcinogen-DNA interaction: differential effects of distamycin-a and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate.
Topics: Animals; Carcinogens; Distamycins; DNA; Drug Interactions; Guanine; Liver; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Pyrroles; Rats; Spermine; Sulfuric Acid Esters | 1980 |
tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1.
Topics: Binding, Competitive; Enzyme Inhibitors; Escherichia coli; Guanine; Kinetics; Molecular Structure; Pentosyltransferases; Purines; Pyrimidinones; Pyrroles; RNA, Transfer; Structure-Activity Relationship; Substrate Specificity | 1995 |
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Guanine; Models, Molecular; Molecular Conformation; Molecular Structure; Phosphates; Purine-Nucleoside Phosphorylase; Purines; Pyrimidines; Pyrroles; Structure-Activity Relationship | 1993 |
Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.
Topics: Amino Acid Sequence; Anticodon; Catalysis; Crystallography, X-Ray; Guanine; Metalloproteins; Models, Molecular; Molecular Sequence Data; Nucleic Acid Precursors; Pentosyltransferases; Pyrimidinones; Pyrroles; Recombinant Proteins; RNA, Transfer; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Zinc; Zymomonas | 1996 |
Effect of the 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole residue on the stability of DNA duplexes and triplexes.
Topics: Adenine; Base Composition; Base Sequence; Calorimetry; Cytosine; Deoxyribonucleosides; DNA; Guanine; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Pyrroles; Structure-Activity Relationship; Thermodynamics; Thymine | 1997 |
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanine; Indicators and Reagents; Isoenzymes; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1997 |
Parallel-stranded duplexes and quartet assemblies formed by oligonucleotides containing isoguanine.
Topics: Base Composition; Cytosine; Drug Stability; Guanine; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pyrimidines; Pyrroles | 1997 |
Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interruptions in a polypurine target.
Topics: Acridines; Adenine; Gene Expression Regulation; Genetic Techniques; Guanine; Intercalating Agents; Kinetics; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Purines; Pyrimidines; Pyrroles | 1999 |
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.
Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Databases as Topic; Drug Design; Dysentery, Bacillary; Enzyme Inhibitors; Guanine; Kinetics; Models, Molecular; Molecular Structure; Pentosyltransferases; Phthalazines; Pyrimidinones; Pyrroles; Shigella flexneri; Software; Static Electricity; Thermodynamics; Zymomonas | 2001 |
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Design; Folic Acid Antagonists; Glutamates; Guanine; Humans; Liver; Models, Molecular; Molecular Conformation; Pemetrexed; Pneumocystis; Pyrimidines; Pyrroles; Rats; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 2001 |
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.
Topics: Animals; Antineoplastic Agents; Biopsy; Carmustine; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Doxorubicin; Fenretinide; Guanine; Humans; Indoles; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Pyrroles; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays | 2001 |
Preparation and enzymatic recognition of guanine lesions induced by nitrogen oxides.
Topics: Deoxyribonucleotides; DNA Damage; DNA Glycosylases; DNA Repair; Guanine; In Vitro Techniques; N-Glycosyl Hydrolases; Nitric Oxide; Nitrogen Dioxide; Nucleotides; Purine Nucleosides; Pyrroles; Xanthine | 2000 |
Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes.
Topics: Animals; Antimony; Arsenic; Biotransformation; Cattle; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; Guanine; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Keratinocytes; Membrane Proteins; Oxidation-Reduction; Protein Precursors; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Spleen | 2003 |
A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Glutamates; Guanine; Methotrexate; Molecular Structure; Pemetrexed; Pyrimidines; Pyrroles | 2003 |
Energetic basis for selective recognition of T*G mismatched base pairs in DNA by imidazole-rich polyamides.
Topics: Base Pair Mismatch; Base Sequence; Binding Sites; Calorimetry; DNA; DNA Footprinting; Guanine; Imidazoles; Nylons; Pyrroles; Surface Plasmon Resonance; Thermodynamics; Thymine | 2004 |
Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Combined Modality Therapy; Endothelial Cells; Glutamates; Guanine; Humans; Indoles; Neoplasms; Neovascularization, Pathologic; Pemetrexed; Protein-Tyrosine Kinases; Pyrroles; Tumor Stem Cell Assay | 2004 |
Structure of human PNP complexed with ligands.
Topics: Azaguanine; Binding Sites; Crystallography, X-Ray; Guanine; Guanosine; Humans; Inosine; Ligands; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles | 2005 |
Interleukin-6 (IL-6)-174 G/C polymorphism--lack of association with inflammatory and haemostatic variables in patients with coronary heart disease treated with atorvastatin and quinapril.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Atorvastatin; Biomarkers; Coronary Disease; Cytosine; Drug Therapy, Combination; Genotype; Guanine; Hemostasis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Polymorphism, Genetic; Pyrroles; Quinapril; Tetrahydroisoquinolines; Treatment Outcome | 2006 |
Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes.
Topics: Binding Sites; DNA; Enzyme Inhibitors; G-Quadruplexes; Guanine; Models, Molecular; Nucleic Acid Conformation; Porphyrins; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Telomerase; Thermodynamics | 2006 |
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.
Topics: Bacillus subtilis; Catalysis; Computational Biology; Crystallization; Crystallography, X-Ray; GTP Cyclohydrolase; Guanine; Models, Chemical; Models, Molecular; NADP; Nucleoside Q; Oxidoreductases; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Pyrimidinones; Pyrroles; RNA Processing, Post-Transcriptional; RNA, Transfer; X-Ray Diffraction | 2005 |
The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.
Topics: Crystallography, X-Ray; Guanine; Humans; Hydrogen-Ion Concentration; Molecular Structure; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Pyrroles; Substrate Specificity; Thioguanine | 2006 |
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.
Topics: Adenine; Base Pairing; Base Sequence; Bisbenzimidazole; Cytosine; DNA; Guanine; Imidazoles; Molecular Sequence Data; Nylons; Peptides; Pyrroles; Temperature; Thymine | 2006 |
Ethynyl-linked (pyreno)pyrrole-naphthyridine and aniline-naphthyridine molecules as fluorescent sensors of guanine via multiple hydrogen bondings.
Topics: Alkylation; Aniline Compounds; Cross-Linking Reagents; Fluorescent Dyes; Guanine; Hydrogen Bonding; Molecular Structure; Naphthyridines; Pyrenes; Pyrroles | 2007 |
Specific recognition of human telomeric G-quadruplex DNA with small molecules and the conformational analysis by ESI mass spectrometry and circular dichroism spectropolarimetry.
Topics: Base Sequence; Circular Dichroism; DNA; G-Quadruplexes; Guanine; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Nucleic Acid Conformation; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Telomere | 2007 |
CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Topics: Base Pairing; Cytosine; DNA; Guanine; Hydrogen Bonding; Nucleosides; Pyrimidinones; Pyrroles | 2007 |
Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond.
Topics: Cytosine; DNA, Complementary; Fluorescent Dyes; Guanine; Hydrogen Bonding; Models, Molecular; Nucleic Acid Hybridization; Oligonucleotides; Peptide Nucleic Acids; Pyrroles; Quantum Theory; RNA | 2008 |
Design of an ultimate quencher free molecular beacon containing pyrrolocytidine-guanine base pair.
Topics: Base Pairing; Cytidine; Fluorescent Dyes; Guanine; Oligonucleotide Probes; Pyrroles; Sequence Analysis, DNA; Spectrometry, Fluorescence | 2008 |
ESI-MS characterization of a novel pyrrole-inosine nucleoside that interacts with guanine bases.
Topics: Base Composition; Base Sequence; DNA, Single-Stranded; G-Quadruplexes; Guanine; Hydrogen Bonding; Inosine; Ligands; Nucleosides; Oligonucleotides; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity | 2008 |
Two independent label-free detection methods in one electrochemical DNA sensor.
Topics: Base Sequence; Biosensing Techniques; DNA; Electrochemical Techniques; Gold; Guanine; Oligonucleotide Probes; Oxidation-Reduction; Polymers; Pyrroles | 2009 |
Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.
Topics: Amino Acid Sequence; Escherichia coli; Evolution, Molecular; Guanine; Humans; Kinetics; Molecular Sequence Data; Mutation; Pentosyltransferases; Phylogeny; Pyrimidinones; Pyrroles; Sequence Homology, Amino Acid; Substrate Specificity | 2011 |
DNA immobilization on a polypyrrole nanofiber modified electrode and its interaction with salicylic acid/aspirin.
Topics: Animals; Aspirin; Cattle; Dielectric Spectroscopy; DNA; Electrochemical Techniques; Electrodes; Guanine; Nanofibers; Oxidation-Reduction; Polymers; Pyrroles; Salicylic Acid | 2011 |
Parallel-stranded DNA: enhancing duplex stability by the 'G-clamp' and a pyrrolo-dC derivative.
Topics: Cytosine; DNA; Guanine; Molecular Structure; Nucleosides; Pyrroles | 2012 |
Investigating the prevalence of queuine in Escherichia coli RNA via incorporation of the tritium-labeled precursor, preQ(1).
Topics: Acrylic Resins; Electrophoresis, Agar Gel; Escherichia coli; Guanine; Isotope Labeling; Pyrimidinones; Pyrroles; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Transfer; Tritium | 2012 |
Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base.
Topics: Guanine; Molecular Structure; Pyrimidinones; Pyrroles | 2012 |
Acute tubular necrosis associated with mTOR inhibitor therapy: a real entity biopsy-proven.
Topics: Acute Kidney Injury; Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Carcinoma, Renal Cell; Cisplatin; Cyclophosphamide; Diphosphonates; Doxorubicin; Female; Glutamates; Guanine; Humans; Imidazoles; Indoles; Interferons; Kidney Tubules; Lung Neoplasms; Lymphoma, B-Cell; Male; Mediastinal Neoplasms; Middle Aged; Necrosis; Nephrectomy; Pemetrexed; Prednisone; Pyrroles; Sunitinib; TOR Serine-Threonine Kinases; Vincristine; Zoledronic Acid | 2013 |
Electrochemical preparation of sodium dodecylsulfate doped over-oxidized polypyrrole/multi-walled carbon nanotube composite on glassy carbon electrode and its application on sensitive and selective determination of anticancer drug: pemetrexed.
Topics: Adsorption; Antineoplastic Agents; Electrodes; Glutamates; Guanine; Hydrogen-Ion Concentration; Limit of Detection; Nanotubes, Carbon; Oxidation-Reduction; Pemetrexed; Polymers; Pyrroles; Sodium Dodecyl Sulfate | 2014 |
Overoxidized polypyrrole/graphene nanocomposite with good electrochemical performance as novel electrode material for the detection of adenine and guanine.
Topics: Adenine; Animals; Biosensing Techniques; Cattle; DNA; Electrochemical Techniques; Electrodes; Graphite; Guanine; Hydrogen-Ion Concentration; Limit of Detection; Microscopy, Electron, Scanning; Nanocomposites; Oxidation-Reduction; Polymers; Pyrroles; Reproducibility of Results; Spectroscopy, Fourier Transform Infrared | 2014 |
Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments.
Topics: Anthramycin; Benzodiazepines; DNA; DNA Breaks; Guanine; Molecular Dynamics Simulation; Nucleic Acid Conformation; Pyrroles | 2016 |
Biophysical properties, thermal stability and functional impact of 8-oxo-7,8-dihydroguanine on oligonucleotides of RNA-a study of duplex, hairpins and the aptamer for preQ1 as models.
Topics: Aptamers, Nucleotide; DNA; Guanine; Inverted Repeat Sequences; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligoribonucleotides; Pyrimidinones; Pyrroles | 2017 |
Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.
Topics: Anthramycin; Base Sequence; Benzodiazepines; Binding Sites; Deoxyribonuclease I; DNA; DNA Footprinting; Guanine; Molecular Dynamics Simulation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Pyrroles; Spectrometry, Fluorescence; Temperature | 2017 |
Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex.
Topics: Base Pairing; Base Sequence; Binding Sites; DNA; G-Quadruplexes; Guanine; Imidazoles; Ligands; Lysine; Nylons; Protons; Pyrroles; Thermodynamics | 2018 |
Proton Transfer and Tautomerism in 2-Aminopurine-Thymine and Pyrrolocytosine-Guanine Base Pairs.
Topics: 2-Aminopurine; Base Pairing; Cytosine; Electrons; Guanine; Models, Molecular; Protons; Pyrroles; Quantum Theory; Stereoisomerism; Thermodynamics; Thymine | 2018 |
7-Deazaguanine modifications protect phage DNA from host restriction systems.
Topics: Archaeal Viruses; Bacteriophages; DNA; DNA Restriction Enzymes; Guanine; Pyrimidinones; Pyrroles | 2019 |
Protein unties the pseudoknot: S1-mediated unfolding of RNA higher order structure.
Topics: 2-Aminopurine; Binding Sites; Escherichia coli; Guanine; Ligands; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Ribosomal Proteins; Ribosomes; Riboswitch; RNA; RNA Folding; Single Molecule Imaging | 2020 |
Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs.
Topics: Bacteriophages; Base Sequence; CRISPR-Cas Systems; DNA; DNA Restriction-Modification Enzymes; Escherichia coli; Gene Editing; Guanine; Humans; Nanopore Sequencing; Nucleotide Motifs; Pyrimidinones; Pyrroles; Siphoviridae | 2020 |
DNA with Purine-Purine Base Pairs: Size and Position of Isoguanine and 8-Aza-7-deazaisoguanine Clickable Residues Control the Molecular Recognition of Guanine and 5-Aza-7-deazaguanine.
Topics: Base Pairing; DNA; Guanine; Nucleic Acid Conformation; Oligonucleotides; Purines; Pyrenes; Pyrimidines; Pyrroles | 2022 |