Page last updated: 2024-08-25

oxazolidin-2-one and pyrazines

oxazolidin-2-one has been researched along with pyrazines in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's11 (84.62)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Chamberlin, AR; Habay, SA; Okamura, N; Reinscheid, RK; Zeng, J1
Clark, SD; Reinscheid, RK; Tran, HT; Zeng, J1
Calo', G; Camarda, V; Ciccocioppo, R; Cifani, C; Filaferro, M; Guerrini, R; Pela', M; Reinscheid, RK; Rizzi, A; Ruggieri, V; Ruzza, C; Salvadori, S; Trapella, C; Vitale, G1
Bertolasi, V; Calo, G; Camarda, V; Cavazzini, A; Costa, V; Del Zoppo, L; Guerrini, R; Pela, M; Reinscheid, RK; Ruzza, C; Salvadori, S; Trapella, C1
Buell, DR; Dine, J; Eder, M; Herrmann, L; Holsboer, F; Ionescu, IA; Landgraf, R; Schmidt, U; Yen, YC1
Deschamps, JR; Fennell, T; Garau, C; Gilmour, B; Graf, T; Hassler, C; Reinscheid, RK; Runyon, SP; Snyder, R; Zhang, Y1
Chen, WM; Chen, Y; Huangfu, DS; Lin, J; Ruan, ZX; Sun, PH; Wang, F1
Asth, L; Gavioli, EC; Guerrini, R; Ruzza, C; Trapella, C1
Hashimoto, K; Ishima, T; Iyo, M; Oda, Y; Okamura, N; Shirayama, Y1
Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM1
Ensho, T; Murakami, N; Nakahara, K; Suzuki, Y1
Gu, Y; Ma, T; Pusch, S; von Deimling, A; Xu, Y; Yang, L; Zha, X; Zhu, Q; Zou, F1
Cai, CC; Chen, HL; Cong, CY; Cui, GF; Dong, CY; Hou, YP; Kong, XP; Li, J; Ren, YL; Shao, YF; Wang, C; Xie, JF; Xin, L1

Reviews

1 review(s) available for oxazolidin-2-one and pyrazines

ArticleYear
Biotransformation and bioactivation reactions - 2015 literature highlights.
    Drug metabolism reviews, 2016, Volume: 48, Issue:2

    Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles

2016

Other Studies

12 other study(ies) available for oxazolidin-2-one and pyrazines

ArticleYear
Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:3

    Topics: Animals; Cell Line; Humans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuropeptides; Oxazolidinones; Pyrazines; Receptors, G-Protein-Coupled

2008
Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function.
    Peptides, 2010, Volume: 31, Issue:1

    Topics: Amino Acid Sequence; Animals; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxazolidinones; Protein Processing, Post-Translational; Protein Structure, Secondary; Pyrazines; Radioligand Assay; Receptors, G-Protein-Coupled; Sequence Alignment; Structure-Activity Relationship

2010
Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.
    Peptides, 2010, Volume: 31, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Caffeine; Cell Line; Eating; Exploratory Behavior; Humans; Male; Maze Learning; Mice; Motor Activity; Neuropeptides; Oxazolidinones; Pyrazines; Rats; Receptors, Neuropeptide

2010
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
    Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8

    Topics: Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Molecular; Oxazolidinones; Pyrazines; Receptors, Neuropeptide; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2011
Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; CA1 Region, Hippocampal; Carbocyanines; Cell Line, Transformed; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; In Vitro Techniques; Intravitreal Injections; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurofilament Proteins; Neurons; Neuropeptides; Oxazolidinones; Protein Transport; Pyrazines; Receptors, AMPA; Receptors, Neuropeptide; Rhodamines; RNA, Messenger; Synapsins; Transfection

2012
Identification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation.
    ACS chemical neuroscience, 2014, Aug-20, Volume: 5, Issue:8

    Topics: Animals; CHO Cells; Cricetulus; Crystallography, X-Ray; Humans; Hydrophobic and Hydrophilic Interactions; Isomerism; Male; Mice, Inbred C57BL; Molecular Structure; Motor Activity; Neuropeptides; Neurotransmitter Agents; Oxazolidinones; Pyrazines; Receptors, Neuropeptide; Solubility; Structure-Activity Relationship; Water

2014
Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring Unit.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; Gram-Positive Bacteria; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Microbial Sensitivity Tests; Nitric Oxide; Oxazolidinones; Pyrazines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2015
Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.
    Neuropharmacology, 2015, Volume: 97

    Topics: Aggression; Animals; Central Nervous System Agents; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Neuropeptides; Oxazolidinones; Phenotype; Psychotropic Drugs; Pyrazines; Random Allocation; Receptors, Neuropeptide; Valproic Acid

2015
Opposite roles for neuropeptide S in the nucleus accumbens and bed nucleus of the stria terminalis in learned helplessness rats.
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Depressive Disorder; Disease Models, Animal; Helplessness, Learned; Male; Memory; Motor Activity; Neuropeptides; Nucleus Accumbens; Oxazolidinones; Pyrazines; Rats, Sprague-Dawley; Receptors, Neuropeptide; Septal Nuclei

2015
Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.
    Neuropeptides, 2017, Volume: 65

    Topics: Adrenergic beta-Antagonists; Animals; Brain Stem; Circadian Rhythm; Corticosterone; Energy Metabolism; Epinephrine; Hypothalamus; Male; Motor Activity; Neuropeptides; Oxazolidinones; Pyrazines; Rats, Wistar; Receptors, Neuropeptide; RNA, Messenger; Sympathetic Nervous System; Thermogenesis

2017
Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.
    Bioorganic & medicinal chemistry, 2017, 12-15, Volume: 25, Issue:24

    Topics: Cell Survival; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Molecular Docking Simulation; Molecular Structure; Mutation; Oxazolidinones; Pyrazines; Structure-Activity Relationship

2017
Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory.
    Chemical senses, 2020, 04-17, Volume: 45, Issue:3

    Topics: Animals; Infusions, Intraventricular; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Neurotransmitter Agents; Olfactory Perception; Oxazolidinones; Pyrazines; Receptors, Neuropeptide; Spatial Memory

2020
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