Page last updated: 2024-09-04

lidorestat and fr 74366

lidorestat has been researched along with fr 74366 in 2 studies

Compound Research Comparison

Studies (lidorestat)	Trials (lidorestat)	Recent Studies (post-2010) (lidorestat)	Studies (fr 74366)	Trials (fr 74366)	Recent Studies (post-2010) (fr 74366)
6	0	2	48	2	7

Protein Interaction Comparison

Protein	Taxonomy	fr 74366 (IC50)
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	0.0044
Aldo-keto reductase family 1 member A1	Homo sapiens (human)	6.6027
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	2.0005

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC	1
Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M	1

Other Studies

2 other study(ies) available for lidorestat and fr 74366

Article	Year
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution	2005
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics	2007

Article

Year

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution

2005

Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.

Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics

2007