lidorestat has been researched along with fr 74366 in 2 studies
Studies (lidorestat) | Trials (lidorestat) | Recent Studies (post-2010) (lidorestat) | Studies (fr 74366) | Trials (fr 74366) | Recent Studies (post-2010) (fr 74366) |
---|---|---|---|---|---|
6 | 0 | 2 | 48 | 2 | 7 |
Protein | Taxonomy | lidorestat (IC50) | fr 74366 (IC50) |
---|---|---|---|
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.0044 | |
Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 6.6027 | |
Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 2.0005 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC | 1 |
Degliesposti, G; Ferrari, AM; Rastelli, G; Sgobba, M | 1 |
2 other study(ies) available for lidorestat and fr 74366
Article | Year |
---|---|
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complications; Diabetes Mellitus, Experimental; Humans; Indoleacetic Acids; Lens, Crystalline; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Structure-Activity Relationship; Thiazoles; Tissue Distribution | 2005 |
Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Binding Sites; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Inhibitory Concentration 50; Models, Biological; Molecular Structure; Thermodynamics | 2007 |