isoxazoles has been researched along with valine in 56 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (3.57) | 18.7374 |
1990's | 4 (7.14) | 18.2507 |
2000's | 18 (32.14) | 29.6817 |
2010's | 27 (48.21) | 24.3611 |
2020's | 5 (8.93) | 2.80 |
Authors | Studies |
---|---|
Berger, AE; Bhuyan, BK; Blowers, CL; Kuentzel, SL; Neil, GL | 1 |
Gerok, W; Häussinger, D; Pausch, J; Rasenack, J | 1 |
Akaike, N; Murai, Y; Nielsen, M; Noguchi, K; Westh-Hansen, SE; Witt, MR | 1 |
Brown, EL; Burke, BJ; Dragovich, PS; Ferre, RA; Ford, CE; Fuhrman, SA; Harr, JE; Hendrickson, TF; Kosa, MB; Lee, CA; Marakovits, JT; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Rejto, PA; Tuntland, T; Webber, SE; Worland, ST; Zhou, R | 1 |
Binford, SL; Brothers, MA; Brown, EL; DeLisle, DM; Dragovich, PS; Ferre, RA; Ford, CE; Fuhrman, SA; Hendrickson, TF; Love, RA; Marakovits, JT; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Tikhe, J; Webber, SE; Worland, ST; Zalman, LS; Zhou, R | 1 |
Binford, SL; Brothers, MA; Diem, MD; Dragovich, PS; Ford, CE; Fuhrman, SA; Jackson, RL; Maldonado, F; Matthews, DA; Meador, JW; Patick, AK; Prins, TJ; Worland, ST; Zalman, LS; Zhou, R | 1 |
Brothers, MA; Dragovich, PS; Patick, AK; Prins, TJ; Worland, ST; Zalman, LS; Zhou, R | 1 |
Crump, CE; Hayden, FG; Kaiser, L | 1 |
Turner, RB | 1 |
Witherell, G | 1 |
Hee, B; Lee, CA; Liang, B; Potts, BC; Zhang, KE | 1 |
Doi, H; Komatsu, H; Nishihira, T; Satomi, S | 1 |
Gersten, M; Hsyu, PH; Kerr, BM; Penning, CA; Pithavala, YK | 1 |
Anand, K; Hilgenfeld, R; Mesters, JR; Wadhwani, P; Ziebuhr, J | 1 |
Chi-Burris, K; Gersten, M; Gwaltney, JM; Hayden, FG; Hsyu, P; Patick, AK; Smith, GJ; Turner, RB; Zalman, LS | 1 |
Clarke, VR; Collingridge, GL | 1 |
Binford, SL; Brothers, MA; Maldonado, F; Matthews, DA; Meador, JW; Patick, AK; Weady, PT; Zalman, LS | 1 |
Cheng, YS; Fang, JM; Huang, HJ; Jan, JT; Kuo, CJ; Kuo, TH; Liang, PH; Shie, JJ; Wong, CH; Wu, YT | 1 |
Behr, B; Hoffmann, C; Klotz, KN; Ottolina, G | 1 |
Im, I; Jeon, ES; Kim, YC; Kwon, SJ; Lee, ES; Lee, WG; Lee, YJ; Park, OK; Park, WJ; Rho, SH; Sellamuthu, S; Yang, ST; Yun, SH | 1 |
Tao, J; Zhao, L | 1 |
Binford, SL; Brothers, MA; Maldonado, F; Matthews, DA; Patick, AK; Weady, PT | 1 |
Moreira, R; Santos, MM | 1 |
Cheng, YH; Kung, SH; Liao, NC; Liu, YN; Lu, WW; Tsai, MT | 1 |
Hu, YW; Jiang, T; Shi, BS; Song, ZG; Yuan, ZH; Zhang, XN | 1 |
Hilgenfeld, R | 1 |
Hsu, JT; Hung, HC; Shih, SR; Teng, IF; Tseng, CP; Wang, HC | 1 |
Chen, Z; Gao, F; Gao, GF; Jiang, H; Lin, D; Liu, H; Lu, G; Qi, J; Qian, W; Xu, X; Yan, J | 1 |
Cui, S; Fan, T; Guo, L; Jin, Q; Lei, X; Wang, J; Wang, M; Wu, Z; Yao, X | 1 |
Arnan, C; Canard, B; Coll, M; Costenaro, L; Coutard, B; Gorbalenya, AE; Janowski, R; Kaczmarska, Z; Norder, H; Solà, M | 1 |
Chen, L; Hu, Y; Qin, B; Song, Z; Yuan, Z; Zhang, X | 1 |
Guo, Y; Lou, Z; Rao, Z; Ren, Z; Yan, L; Yang, C; Zhang, N | 1 |
Cai, Q; Cai, Y; Chen, C; Chen, S; Chen, X; Li, J; Li, N; Lin, T; Liu, L; Peng, X; Wang, X; Wu, C; Yin, K; Zhang, R | 1 |
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M | 1 |
Stock, I | 1 |
Hilgenfeld, R; Jochmans, D; Ma, Q; Nascimento, MS; Neyts, J; Rocha-Pereira, J | 1 |
Franco, D; Froeyen, M; Hilgenfeld, R; Leyssen, P; Neyts, J; Tijsma, A; Tucker, S | 1 |
Ghildyal, R; Jans, DA; Jensen, LM; Walker, EJ | 1 |
Chen, F; Cheng, G; Fang, Y; Guo, Y; Li, H; Liu, D; Liu, F; Liu, L; Liu, Z; Margetts, P; Tang, L; Zhao, Z | 1 |
Cao, L; Gong, P; Lou, Z; Qing, J; Shang, L; Shu, B; Sun, Y; Wang, Y; Yin, Z | 1 |
Lerner, PP; Lerner, V; Miodownik, C | 1 |
Brooks-Kayal, A; Carlsen, J; Cea-Del Rio, CA; Cruz Del Angel, Y; González, MI; Grabenstatter, HL; Huntsman, MM; Laoprasert, RP; White, AM | 1 |
Ang, MJ; Cheong, YK; Chia, CS; Chu, JJ; Hill, J; Keller, TH; Lau, QY; Ng, FM; Ngoh, ZX; Peng, J; Poulsen, A; Tan, YW; Then, SW | 1 |
George, S; Hilgenfeld, R; Lacroix, C; Leyssen, P; Neyts, J | 1 |
Aeschlimann, F; Baer, W; Berthet, G; Cannizzaro, E; Heininger, U; Hofer, M; Kaiser, D; Leuvenink, R; Schroeder, S; Woerner, A | 1 |
Altmeyer, R; Gao, Q; Lan, K; Li, G; Wang, Y; Yuan, S; Zou, G | 1 |
Hannongbua, S; Jetsadawisut, W; Kungwan, N; Meeprasert, A; Nutho, B; Rungrotmongkol, T; Wolschann, P | 1 |
Cao, L; Shang, L; Sun, Y; Wang, Y; Yin, Z; Zhai, Y | 1 |
Emmott, E; Goodfellow, I; Hosmillo, M; Kitano, M; Lu, J | 1 |
Lv, W; Wang, Y; Zhang, M; Zhang, Y | 1 |
Chen, S; Chen, X; Cheng, A; Jia, R; Liu, M; Liu, Y; Mao, S; Sun, D; Wang, M; Wen, X; Wu, Y; Yang, Q; Yu, Y; Zhang, L; Zhang, S; Zhao, X; Zhu, D | 1 |
Chen, Z; Fan, K; Hou, H; Sun, Y; Yuan, S; Zhu, L | 1 |
Beinke, S; Belyaev, NN; Braubach, P; Braun, A; Fieguth, HG; Hessel, EM; Jonigk, D; Lennon, MG; Obernolte, H; Saunders, KA; Schaudien, D; Sewald, K; Warnecke, G; Wilkens, L; Wronski, S; Zardo, P | 1 |
Henes, M; Kurt Yilmaz, N; Lee, JM; Lockbaum, GJ; Nalivaika, EA; Schiffer, CA; Thompson, PR; Timm, J | 1 |
Bervoets, L; Cuvry, A; Dai, W; de Witte, P; Li, B; Li, J; Liu, H; Neyts, J; Rocha-Pereira, J; Roux, E; Rymenants, J; Stylianidou, Z; Van Dycke, J | 1 |
Croft, SN; Ghildyal, R; Walker, EJ | 1 |
8 review(s) available for isoxazoles and valine
Article | Year |
---|---|
The treatment of rhinovirus infections: progress and potential.
Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc | 2001 |
AG-7088 Pfizer.
Topics: Antiviral Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine | 2000 |
[Anti-cancer therapy with amino acid imbalance].
Topics: Amino Acids; Antimetabolites, Antineoplastic; Arginine; Asparagine; Glutamine; Humans; Isoxazoles; Methionine; Neoplasms; Valine | 2001 |
An integrated approach to developing chemoenzymatic processes at the industrial scale.
Topics: Bacillus; Biotechnology; Biotransformation; Catalysis; Chemistry, Pharmaceutical; Cost-Benefit Analysis; Drug Design; Enzymes; Fructose-Bisphosphate Aldolase; HIV Protease Inhibitors; Isoxazoles; Models, Chemical; Models, Theoretical; Oxazoles; Pharmaceutical Preparations; Phenylalanine; Pyrrolidines; Pyrrolidinones; Stereoisomerism; Valine | 2006 |
Michael acceptors as cysteine protease inhibitors.
Topics: Animals; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Leucine; Molecular Structure; Oxazoles; Peptides; Phenylalanine; Pyrrolidines; Pyrrolidinones; Structure-Activity Relationship; Sulfones; Valine | 2007 |
[Hand, foot and mouth disease--more than a harmless "childhood disease"].
Topics: Adult; Animals; Antiviral Agents; Child; Child, Preschool; Disease Outbreaks; Hand, Foot and Mouth Disease; Humans; Isoxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Pyrrolidinones; Valine | 2014 |
Proteases of human rhinovirus: role in infection.
Topics: 3C Viral Proteases; Active Transport, Cell Nucleus; Antiviral Agents; Cysteine Endopeptidases; Host-Pathogen Interactions; Humans; Isoxazoles; Peptide Hydrolases; Phenylalanine; Picornaviridae Infections; Pyrrolidinones; Rhinovirus; Valine; Viral Proteins; Virus Replication | 2015 |
Tardive dyskinesia (syndrome): Current concept and modern approaches to its management.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; alpha-Tocopherol; Amantadine; Anticonvulsants; Antioxidants; Antipsychotic Agents; Clonazepam; Dopamine Agents; Drugs, Chinese Herbal; Fatty Acids, Omega-3; Ginkgo biloba; Humans; Isoleucine; Isoxazoles; Leucine; Levetiracetam; Melatonin; Movement Disorders; Nootropic Agents; Piracetam; Plant Extracts; Propranolol; Pyridoxine; Resveratrol; Stilbenes; Tetrabenazine; Valine; Vitamins; Zonisamide | 2015 |
3 trial(s) available for isoxazoles and valine
Article | Year |
---|---|
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers.
Topics: Adult; Antiviral Agents; Double-Blind Method; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Valine | 2002 |
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
Topics: Administration, Inhalation; Adolescent; Adult; Antiviral Agents; Biological Availability; Common Cold; Double-Blind Method; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Mucus; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Suspensions; Valine | 2003 |
Valsartan combined with clopidogrel and/or leflunomide for the treatment of progressive immunoglobulin A nephropathy.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biomarkers; China; Clopidogrel; Creatinine; Disease Progression; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Immunosuppressive Agents; Isoxazoles; Kidney; Leflunomide; Male; Platelet Aggregation Inhibitors; Proteinuria; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Valine; Valsartan | 2015 |
45 other study(ies) available for isoxazoles and valine
Article | Year |
---|---|
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Glycine; Isoxazoles; Leukemia L1210; Leukemia P388; Macromolecular Substances; Male; Mice; Oxazoles; Sex Factors; Thymidine; Uridine; Valine | 1978 |
Hepatic carbamoyl phosphate metabolism. Role of cytosolic and mitochondrial carbamoyl phosphate in de novo pyrimidine synthesis.
Topics: Aminooxyacetic Acid; Animals; Carbamates; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Cytosol; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Isoxazoles; Liver; Mitochondria, Liver; Ornithine Carbamoyltransferase; Orotic Acid; Perfusion; Pyrimidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Transaminases; Valine | 1985 |
Effects of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, on recombinant human GABA(A) receptors.
Topics: Animals; Cell Line; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Piperidines; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Transfection; Valine | 1997 |
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Topics: 3C Viral Proteases; Antiviral Agents; Cell Line; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Glutamine; Humans; Isoxazoles; Lactams; Models, Molecular; Molecular Mimicry; Oligopeptides; Phenylalanine; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine; Viral Proteins | 1999 |
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Binding Sites; Crystallization; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Pyrrolidinones; Rhinovirus; Structure-Activity Relationship; Valine; Viral Proteins | 1999 |
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
Topics: 3C Viral Proteases; Antiviral Agents; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Proteins; Pyrrolidinones; Rhinovirus; Serotyping; Valine; Viral Proteins | 1999 |
Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor.
Topics: 3C Viral Proteases; Antiviral Agents; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytokines; HeLa Cells; Humans; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Pyrrolidinones; Rhinovirus; Time Factors; Valine; Viral Proteins | 2000 |
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses.
Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine | 2000 |
Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease.
Topics: 3C Viral Proteases; Animals; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dogs; Haplorhini; Humans; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Mimicry; Molecular Structure; Peptides; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Valine; Viral Proteins | 2001 |
Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Coronavirus 229E, Human; Coronavirus 3C Proteases; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimerization; Drug Design; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrrolidinones; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Transmissible gastroenteritis virus; Valine | 2003 |
Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Membrane Potentials; Neural Inhibition; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission; Valine | 2004 |
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.
Topics: 3C Viral Proteases; Amino Acids; Antiviral Agents; Conserved Sequence; Cysteine Endopeptidases; HeLa Cells; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; RNA, Viral; Valine; Viral Proteins | 2005 |
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; Computer Simulation; Coronavirus 3C Proteases; Cysteine Endopeptidases; Endopeptidases; Enzyme Inhibitors; Esters; Isoxazoles; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Mimicry; Peptides; Phenylalanine; Pyrrolidinones; Valine; Vero Cells; Viral Proteins | 2005 |
Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Aspartic Acid; CHO Cells; Cricetinae; Humans; Isoleucine; Isoxazoles; Ligands; Lysine; Molecular Sequence Data; Mutagenesis; Protein Structure, Secondary; Protein Structure, Tertiary; Radioligand Assay; Receptors, Adrenergic, beta-1; Terbutaline; Valine | 2006 |
Development of potent inhibitors of the coxsackievirus 3C protease.
Topics: 3C Viral Proteases; Amino Acid Substitution; Amino Acids; Antiviral Agents; Binding Sites; Cell Survival; Cysteine Endopeptidases; Enterovirus; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Models, Molecular; Phenylalanine; Pyrrolidinones; Rhinovirus; Valine; Viral Proteins; Virus Replication | 2007 |
In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.
Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cysteine Endopeptidases; Drug Resistance, Viral; Genotype; Humans; Isoxazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Phenotype; Phenylalanine; Pyrrolidinones; Rhinovirus; Sequence Homology, Amino Acid; Valine; Viral Proteins | 2007 |
Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer.
Topics: 3C Viral Proteases; Antiviral Agents; Biosensing Techniques; Blotting, Western; Cell Fusion; Cell Line; Cysteine Endopeptidases; Enterovirus A, Human; Enterovirus Infections; Fluorescence Resonance Energy Transfer; Fluorometry; Green Fluorescent Proteins; HeLa Cells; Herpesvirus 1, Human; Humans; Image Processing, Computer-Assisted; Isoxazoles; Microbial Sensitivity Tests; Phenylalanine; Plasmids; Pyrrolidinones; Recombinant Proteins; Transfection; Valine; Viral Plaque Assay; Viral Proteins | 2009 |
Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection.
Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cysteine Endopeptidases; Enterovirus A, Human; Enterovirus Infections; Humans; Isoxazoles; Molecular Sequence Data; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Retrospective Studies; Treatment Outcome; Valine; Viral Proteins | 2010 |
Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia.
Topics: Animals; Antiviral Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Developed Countries; Developing Countries; Drug Design; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; RNA Virus Infections; RNA Viruses; Valine | 2010 |
Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir.
Topics: Algorithms; Animals; Antiviral Agents; Blotting, Western; Chlorocebus aethiops; DNA Primers; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Enterovirus A, Human; Enterovirus Infections; Humans; Interferon-alpha; Interferon-Stimulated Gene Factor 3, gamma Subunit; Isoxazoles; Phenylalanine; Polymerase Chain Reaction; Pyrrolidinones; Recombinant Proteins; Rhabdomyosarcoma; Tumor Cells, Cultured; Valine; Vero Cells; Virus Replication | 2011 |
Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design.
Topics: 3C Viral Proteases; Antiviral Agents; Crystallography, X-Ray; Cysteine Endopeptidases; Drug Design; Enterovirus A, Human; Hand, Foot and Mouth Disease; Humans; Isoxazoles; Models, Molecular; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins | 2011 |
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues.
Topics: 3C Viral Proteases; Amino Acid Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus A, Human; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins | 2011 |
Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93.
Topics: 3C Viral Proteases; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus; Enzyme Inhibitors; Humans; Isoxazoles; Models, Molecular; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins | 2011 |
Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model.
Topics: Animals; Antiviral Agents; Drug Evaluation, Preclinical; Enterovirus A, Human; Enterovirus Infections; Female; Humans; Infant; Isoxazoles; Male; Mice; Phenylalanine; Pyrrolidinones; Valine; Virus Replication | 2013 |
The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease.
Topics: Binding Sites; Coronavirus 3C Proteases; Cysteine Endopeptidases; Humans; Isoxazoles; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Pyrrolidinones; Rhinovirus; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Valine; Viral Proteins | 2013 |
Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir.
Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Cell Line; Conserved Sequence; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enterovirus A, Human; Humans; Isoxazoles; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Conformation; Pyrrolidinones; Valine; Viral Proteins | 2013 |
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication | 2014 |
The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.
Topics: Amides; Antiviral Agents; Cell Line; Cysteine Endopeptidases; Cytidine; Drug Combinations; Drug Synergism; Hepatocytes; Humans; Isoxazoles; Molecular Docking Simulation; Norwalk virus; Papain; Phenylalanine; Pyrazines; Pyrrolidinones; Replicon; RNA-Dependent RNA Polymerase; Valine; Viral Proteins; Virus Replication | 2014 |
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication.
Topics: Antiviral Agents; Benzimidazoles; Capsid; Capsid Proteins; Drug Resistance, Viral; Enterovirus A, Human; Enterovirus Infections; Isoxazoles; Molecular Docking Simulation; Oximes; Phenylalanine; Piperidines; Protease Inhibitors; Protein Binding; Pyridazines; Pyrrolidinones; Sulfonamides; Valine; Virus Replication | 2014 |
An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation.
Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Drug Synergism; Enterovirus A, Human; Humans; Isoxazoles; Phenylalanine; Pyrrolidinones; RNA-Dependent RNA Polymerase; Valine; Virus Replication | 2014 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Muscarinic Agonists; Neurons; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Valine | 2015 |
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.
Topics: 3C Viral Proteases; Antiviral Agents; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cysteine Endopeptidases; Enterovirus A, Human; Inhibitory Concentration 50; Isoxazoles; Peptidomimetics; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Structure-Activity Relationship; Valine; Viral Proteins | 2016 |
The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.
Topics: Antiviral Agents; Drug Resistance, Viral; Enterovirus; Isoxazoles; Phenylalanine; Protease Inhibitors; Pyrrolidinones; Valine; Viral Proteins; Virus Replication | 2015 |
Clinical course and therapeutic approach to varicella zoster virus infection in children with rheumatic autoimmune diseases under immunosuppression.
Topics: Acyclovir; Adolescent; Antirheumatic Agents; Antiviral Agents; Arthritis, Juvenile; Chickenpox; Child; Child, Preschool; Etanercept; Female; Herpes Zoster; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Retrospective Studies; Treatment Outcome; Valacyclovir; Valine; Young Adult | 2016 |
In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71.
Topics: Amides; Amino Acid Sequence; Animals; Antiviral Agents; Binding Sites; Cell Line, Tumor; Chlorocebus aethiops; Drug Combinations; Drug Resistance, Viral; Drug Synergism; Enterovirus A, Human; Humans; Indoles; Isoxazoles; Itraconazole; Molecular Docking Simulation; Mutation; Myoblasts; Phenols; Phenylalanine; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Pyrazines; Pyrrolidinones; Sequence Alignment; Sequence Homology, Amino Acid; Suramin; Valine; Vero Cells; Viral Nonstructural Proteins; Virus Replication | 2016 |
Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: A molecular dynamics study.
Topics: 3C Viral Proteases; Cysteine Endopeptidases; Drug Design; Enterovirus; Enterovirus A, Human; Enzyme Inhibitors; Hand, Foot and Mouth Disease; Humans; In Vitro Techniques; Isoxazoles; Molecular Dynamics Simulation; Oligopeptides; Peptides; Phenylalanine; Protein Binding; Pyrrolidinones; Valine; Viral Proteins | 2016 |
Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor.
Topics: 3C Viral Proteases; Antiviral Agents; Cysteine Endopeptidases; Enterovirus; Hand, Foot and Mouth Disease; Isoxazoles; Mutation; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Pyrrolidinones; Valine; Viral Proteins | 2017 |
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells
Topics: 3C Viral Proteases; Amino Acid Sequence; Antiviral Agents; Cell Line, Tumor; Cysteine Endopeptidases; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Mutation; Norwalk virus; Phenylalanine; Pyrrolidinones; Valine; Viral Proteins; Virus Replication | 2018 |
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells | 2019 |
Biochemical characterization of recombinant Avihepatovirus 3C protease and its localization.
Topics: 3C Viral Proteases; Cysteine Endopeptidases; Hepatitis Virus, Duck; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Phenylalanine; Phylogeny; Pyrrolidinones; Recombinant Proteins; Sequence Alignment; Valine; Viral Proteins | 2019 |
Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design.
Topics: 3C Viral Proteases; Antiviral Agents; Crystallography, X-Ray; Drug Design; Enterovirus A, Human; Isoxazoles; Models, Molecular; Phenylalanine; Protein Structure, Tertiary; Pyrrolidinones; Sequence Analysis, DNA; Valine | 2020 |
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Topics: Aged; Antiviral Agents; Asthma; Bronchi; Epithelial Cells; Female; Gene Expression Profiling; Genome, Human; Host-Pathogen Interactions; Humans; Isoxazoles; Lung; Male; Middle Aged; Phenylalanine; Picornaviridae Infections; Pulmonary Disease, Chronic Obstructive; Pyrrolidinones; Rhinovirus; Valine | 2021 |
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Enterovirus D, Human; Hydrogen Bonding; Isoxazoles; Phenylalanine; Protein Binding; Pyrrolidinones; SARS-CoV-2; Static Electricity; Valine | 2021 |
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo.
Topics: Animals; Caliciviridae Infections; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, Viral; Isoxazoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Mutation; Norovirus; Peptide Hydrolases; Phenylalanine; Pyrrolidinones; Replicon; RNA, Viral; Small Molecule Libraries; Valine; Viral Protease Inhibitors; Virus Replication; Zebrafish | 2021 |
RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups.
Topics: 3C Viral Proteases; Antiviral Agents; Apoptosis; HeLa Cells; Host-Pathogen Interactions; Humans; Isoxazoles; Phenylalanine; Picornaviridae Infections; Protease Inhibitors; Pyrrolidinones; Rhinovirus; Valine | 2021 |