Page last updated: 2024-09-03

icrf 198 and glycine

icrf 198 has been researched along with glycine in 21 studies

Compound Research Comparison

Studies
(icrf 198)
Trials
(icrf 198)
Recent Studies (post-2010)
(icrf 198)
Studies
(glycine)
Trials
(glycine)
Recent Studies (post-2010) (glycine)
240435,1637568,415

Protein Interaction Comparison

ProteinTaxonomyicrf 198 (IC50)glycine (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4852
Sodium- and chloride-dependent glycine transporter 1Homo sapiens (human)106
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.3253
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)128

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's10 (47.62)18.2507
2000's6 (28.57)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vile, GF; Winterbourn, CC1
Hasinoff, BB4
Ferrans, VJ; Fukuda, Y; Hasinoff, BB; Herman, EH; Raley, LG; Zhang, J; Zhang, TM1
Hasinoff, BB; Malisza, KL1
Buss, JL; Hasinoff, BB1
Thomas, C; Vile, GF; Winterbourn, CC1
Allan, WP; Creighton, AM; Fattman, CL; Hasinoff, BB; Kuschak, TI; Thampatty, P; Yalowich, JC1
Chadwick, DP; Clark, JR; Ferrans, VJ; Hasinoff, BB; Herman, EH; Zhang, J1
Boehme, P; Gordeuk, VR; John, C; Loyevsky, M; Sacci, JB; Weglicki, W1
Boroujerdi, M; Vaidyanathan, S1
Hasinoff, BB; Schroeder, PE2
Hasinoff, BB; Hofland, KF; Jensen, PB; Langer, SW; Schroeder, PE; Sehested, M1
Hasinoff, BB; Patel, D1
Hrušková, K; Klimeš, J; Kovaříková, P; Stariat, J; Vávrová, K1
Klimes, J; Kovarikova, P; Pasakova-Vrbatova, I; Simunek, T; Stariat, J; Vavrova, A1
Foret, F; Kovarikova, P; Tycova, A; Vido, M1
Brázdová, P; Bureš, J; Chládek, J; Jirkovská, A; Jirkovský, E; Karabanovich, G; Kovaříková, P; Lenčová, O; Pokorná, Z; Roh, J; Šimůnek, T; Stariat, J; Štěrba, M1

Other Studies

21 other study(ies) available for icrf 198 and glycine

ArticleYear
dl-N,N'-dicarboxamidomethyl-N,N'-dicarboxymethyl-1,2-diaminopropane (ICRF-198) and d-1,2-bis(3,5-dioxopiperazine-1-yl)propane (ICRF-187) inhibition of Fe3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adriamycin.
    Cancer research, 1990, Apr-15, Volume: 50, Issue:8

    Topics: Animals; Calcium-Transporting ATPases; Chelating Agents; Cytochrome c Group; Doxorubicin; Ethylenediamines; Ferric Compounds; Glycine; Kinetics; Lipid Peroxidation; Microsomes; Myocardium; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Piperazines; Rabbits; Razoxane; Stereoisomerism

1990
The interaction of the cardioprotective agent ICRF-187 [+)-1,2-bis(3,5-dioxopiperazinyl-1-yL)propane); its hydrolysis product (ICRF-198); and other chelating agents with the Fe(III) and Cu(II) complexes of adriamycin.
    Agents and actions, 1989, Volume: 26, Issue:3-4

    Topics: Cardiotonic Agents; Chelating Agents; Copper; Doxorubicin; Electron Transport Complex IV; Ethylenediamines; Glycine; Iron; Organometallic Compounds; Piperazines; Razoxane; Stereoisomerism; Submitochondrial Particles

1989
Morphologic and morphometric evaluation of the effect of ICRF-187 on bleomycin-induced pulmonary toxicity.
    Toxicology, 1995, Apr-12, Volume: 98, Issue:1-3

    Topics: Animals; Bleomycin; Ethylenediamines; Female; Glycine; Iron; Lung; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Models, Chemical; Razoxane; Spectrophotometry

1995
NADPH-cytochrome-P450 reductase promotes hydroxyl radical production by the iron complex of ADR-925, the hydrolysis product of ICRF-187 (dexrazoxane).
    Free radical research, 1995, Volume: 22, Issue:4

    Topics: Animals; Catalase; Chelating Agents; Edetic Acid; Electron Spin Resonance Spectroscopy; Ethylenediamines; Glycine; Hydroxyl Radical; Iron Chelating Agents; Models, Chemical; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Rats; Razoxane; Spectrophotometry, Ultraviolet

1995
Doxorubicin reduces the iron(III) complexes of the hydrolysis products of the antioxidant cardioprotective agent dexrazoxane (ICRF-187) and produces hydroxyl radicals.
    Archives of biochemistry and biophysics, 1995, Feb-01, Volume: 316, Issue:2

    Topics: Aerobiosis; Antibiotics, Antineoplastic; Antioxidants; Chelating Agents; Doxorubicin; Electron Spin Resonance Spectroscopy; Ethylenediamines; Ferric Compounds; Ferrous Compounds; Glycine; Heart; Hydrolysis; Hydroxyl Radical; Mitoxantrone; Models, Chemical; Oxidation-Reduction; Razoxane

1995
Quantitation of the dexrazoxane hydrolysis product ADR-925 by fluorescence detection of its terbium(III) complex after high-performance liquid chromatographic separation.
    Journal of chromatography. B, Biomedical applications, 1994, Jun-17, Volume: 656, Issue:2

    Topics: Chelating Agents; Chromatography, High Pressure Liquid; Ethylenediamines; Glycine; Humans; Razoxane; Spectrometry, Fluorescence; Terbium

1994
The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes.
    Agents and actions, 1993, Volume: 40, Issue:1-2

    Topics: Anthracenes; Ethylenediamines; Glycine; Hydrolysis; Iron; Kinetics; Models, Molecular; Razoxane; Spectrophotometry, Infrared

1993
The hydrolysis product of ICRF-187 promotes iron-catalysed hydroxyl radical production via the Fenton reaction.
    Biochemical pharmacology, 1993, May-25, Volume: 45, Issue:10

    Topics: Ascorbic Acid; Chelating Agents; Deoxyribose; Dimethyl Sulfoxide; Doxorubicin; Edetic Acid; Ethylenediamines; Ferric Compounds; Glycine; Hydrogen Peroxide; Hydrolysis; Hydroxides; Hydroxyl Radical; Iron; Kinetics; Oxidation-Reduction; Paraquat; Razoxane; Superoxides; Thiobarbituric Acid Reactive Substances; Xanthine Oxidase

1993
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: Aclarubicin; Animals; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Drug Resistance; Ethylenediamines; Etoposide; Glycine; Mutation; Razoxane; Thiobarbiturates; Topoisomerase II Inhibitors; Verapamil

1997
Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron (III) displacement reactions of ICRF-187 and other bisdiketopiperazines.
    Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Cardiovascular Agents; Chelating Agents; Diketopiperazines; DNA Topoisomerases, Type II; Doxorubicin; Ethylenediamines; Glycine; Heart; Hydrolysis; Iron; Male; Myocardium; Piperazines; Rats; Rats, Inbred SHR; Razoxane

1997
Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures.
    Experimental parasitology, 1999, Volume: 91, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deferoxamine; Erythrocytes; Ethylenediamines; Ferrous Compounds; Fluoresceins; Fluorescent Dyes; Glycine; Humans; Iron Chelating Agents; Liver; Malaria, Falciparum; Mice; Microscopy, Fluorescence; Parasitemia; Plasmodium falciparum; Plasmodium yoelii; Prodrugs; Quaternary Ammonium Compounds; Razoxane; Spectrometry, Fluorescence; Surface Properties

1999
Interaction of dexrazoxane with red blood cells and hemoglobin alters pharmacokinetics of doxorubicin.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:2

    Topics: Animals; Chelating Agents; Doxorubicin; Endothelins; Erythrocyte Membrane; Erythrocytes; Ethylenediamines; Female; Glycine; Hemoglobins; Kinetics; Rats; Rats, Sprague-Dawley; Razoxane

2000
Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage.
    Cardiovascular toxicology, 2002, Volume: 2, Issue:2

    Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Extracorporeal Membrane Oxygenation; Fluoresceins; Fluorescent Dyes; Glycine; Hypoxia; Ion Transport; L-Lactate Dehydrogenase; Models, Cardiovascular; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Razoxane; Time Factors; Treatment Failure

2002
The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:6

    Topics: Animals; Biotransformation; Cardiovascular Agents; Chelating Agents; Chromatography, High Pressure Liquid; Ethylenediamines; Fluoresceins; Glycine; Half-Life; Indicators and Reagents; Infusions, Intravenous; Iron; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Razoxane

2002
Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:2

    Topics: Aged; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Ethylenediamines; Etoposide; Female; Glycine; Half-Life; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Razoxane

2003
Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:9

    Topics: Amidohydrolases; Animals; Brain; Cardiotonic Agents; Chelating Agents; Dihydroorotase; Ethylenediamines; Glycine; Hepatocytes; Liver; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Razoxane

2005
The iron chelator Dp44mT does not protect myocytes against doxorubicin.
    Journal of inorganic biochemistry, 2009, Volume: 103, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cells, Cultured; Cytoprotection; Doxorubicin; Ethylenediamines; Glycine; Iron Chelating Agents; L-Lactate Dehydrogenase; Myocytes, Cardiac; Pyridines; Rats; Rats, Sprague-Dawley; Razoxane; Thiosemicarbazones

2009
Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites--the cardioprotectant dexrazoxane as a model case.
    Journal of chromatography. A, 2011, Jan-21, Volume: 1218, Issue:3

    Topics: Cardiovascular Agents; Chromatography, Liquid; Ethylenediamines; Glycine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Models, Chemical; Razoxane; Tandem Mass Spectrometry; Temperature

2011
Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium.
    Journal of pharmaceutical and biomedical analysis, 2013, Mar-25, Volume: 76

    Topics: Animals; Animals, Newborn; Cardiovascular Agents; Cells, Cultured; Chromatography, Liquid; Ethylenediamines; Glycine; Myocytes, Cardiac; Pilot Projects; Rabbits; Rats; Rats, Wistar; Razoxane; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2013
Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma.
    Journal of chromatography. A, 2016, Sep-30, Volume: 1466

    Topics: Blood Chemical Analysis; Dexrazoxane; Electrophoresis, Capillary; Ethylenediamines; Glycine; Spectrometry, Mass, Electrospray Ionization

2016
Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 364, Issue:3

    Topics: Animals; Cardiotonic Agents; Dexrazoxane; Ethylenediamines; Glycine; Myocytes, Cardiac; Rabbits; Rats; Tissue Distribution

2018