Page last updated: 2024-08-17

folic acid and guanine

folic acid has been researched along with guanine in 115 studies

Research

Studies (115)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (14.78)	18.7374
1990's	7 (6.09)	18.2507
2000's	59 (51.30)	29.6817
2010's	31 (26.96)	24.3611
2020's	1 (0.87)	2.80

Authors

Authors	Studies
Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J	1
Fukushima, T; Shiota, T	1
Poirier, LA	1
Dewey, VC; Kidder, GW	1
D'Ari, L; Rabinowitz, JC; Samuel, CE	1
DeMars, R; Felix, JS	1
Lazányi, A	1
Gasser, F; Mandel, M; Rogosa, M	1
Pegg, AE; Wiest, L	1
Taylor, EC	1
Calvert, AH; Jackman, AL	1
Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL	2
Calvert, H	2
Danenberg, PV; Malli, H; Swenson, S	1
Babani, S; Gao, F; Goldman, ID; Liu, L; Zhao, R	1
Cassidy, J	1
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D	1
Evans, VJ; Price, FM; Rotherham, J	1
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH	1
Fossella, FV; Gatzemeier, U	1
Bunn, PA; Calvert, H	1
Bunn, PA	1
Allen, RH; Baker, SD; Calvert, AH; Nelson, K; Niyikiza, C; Paoletti, P; Rusthoven, JJ; Seitz, DE; Stabler, SP; Walling, JM	1
Allen, R; Bunn, PA; Calvert, AH; Hanauske, AR; Niyikiza, C; Paoletti, P; Rusthoven, JJ	1
Kindler, HL	1
Bajetta, E; Buzzoni, R; Celio, L; Longarini, R; Marchianò, A	1
Goldman, ID; Wang, Y; Zhao, R	2
Blatter, J; Burris, H; Gatzemeier, U; Keppler, U; Kindler, HL; Manegold, C; Rusthoven, JJ; Scagliotti, GV; Shin, DM; Symanowski, JT; Vasconcelles, MJ	1
Blom, HJ; den Heijer, M; Klerk, M; Kluijtmans, LA; Kok, FJ; Lievers, KJ; Schouten, EG; Verhoef, P	1
DIETRICH, LS; KREAM, J; SHAPIRO, DM	1
GORTON, BS; RAVEL, JM; SHIVE, W	1
BROWN, GM; REYNOLDS, JJ	2
HUTCHISON, DJ; JOHNSON, AH	1
ALBRECHT, AM; HUTCHISON, DJ	1
BRINDLE, SD; HIRSCHBERG, E; SEMENTE, G	1
SPRECHER, M; SPRINSON, DB	1
Bajetta, E; Becerra, C; Buzzoni, R; Celio, L; Ferrari, L; Ilardi, C; John, W; Longarini, R; Marchianò, A; Martinetti, A	1
Blatter, J; Hanauske, A; Ohnmacht, U; Sauter, T; Thödtmann, R; Weinknecht, S; Weissbach, L	1
Jackman, AL; Theti, DS	1
Adjei, AA	2
Green, MR; Meyer, ML; Suwanrusme, H	1
Fossella, FV; Herbst, RS; Zinner, RG	1
Hazarika, M; Johnson, JR; Pazdur, R; White, RM	1
Chattopadhyay, S; Goldman, ID; Wang, Y; Zhao, R	1
Budde, LS; Hanna, NH	1
Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R	1
Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhang, S; Zhao, R	1
Scagliotti, GV	1
Ghosh, A; Johnson, RD; Karlsson, MO; Latz, JE; Rusthoven, JJ	1
Rahman, A; White, RM	1
Baker, SD; Chaudhary, AK; Chaudhuri, T; Goetz, A; Hammond, LA; Johnson, RD; Latz, JE; Mita, AC; Molpus, K; Patnaik, A; Rowinsky, EK; Sandler, A; Simms, L; Sweeney, CJ; Takimoto, CH; Tolcher, AW; Villalona-Calero, M	1
Mita, AC; Takimoto, CH	1
Adachi, S; Fukuoka, M; Kudoh, S; Latz, JE; Matsui, K; Nakagawa, K; Negoro, S; Yamamoto, N	1
Bajorin, DF; Boyle, MG; Galsky, MD; Iasonos, A; Mironov, S; Scattergood, J	1
Carrasco, E; Clark, RS; Cruciani, G; Llombart-Cussac, A; Nakamura, T; Rowland, K; Theodoulou, M	1
Chattopadhyay, S; Goldman, ID; Moran, RG	1
de Vos, WM; Smid, EJ; van Oorschot, W; Wegkamp, A	1
Goldman, ID; Zhao, R	1
Beeram, M; Clark, R; de Bono, J; Forero, L; Forouzesh, B; Hammond-Thelin, LA; Latz, JE; Monroe, P; Patnaik, A; Rowinsky, EK; Schneck, KB; Takimoto, CH; Tolcher, AW; Wood, L	1
Anghel, RM; Clark, R; De Grève, J; Eniu, AE; Harbeck, N; Kaiser, CJ; Llombart-Cussac, A; Ma, D; Martin, M; Melemed, AS; Neven, P; Simms, L; Verrill, MW	1
Chattopadhyay, S; Goldman, ID; Min, SH; Tamari, R; Tsai, E; Zhao, R	1
Alberts, SR; Ames, M; Goetz, MP; Goldberg, RM; Gornet, MK; Kim, GP; Mahoney, MR; Nicol, SJ; Rubin, J; Weinshilboum, RM	1
Müller, C; Schibli, R; Schubiger, PA	1
Adjei, AA; Ames, MM; Dy, GK; Endo, C; Leil, TA; Reid, JR; Salavaggione, OE	1
Fang, Q; Javanmard, S; Loktionova, NA; Moschel, RC; Pauly, GT; Pegg, AE	1
Clarke, SJ; Li, KM; Rivory, LP	1
Cho, RC; Cole, PD; Croxford, R; Gaisano, G; Kamen, BA; Kim, YI; Sohn, KJ	1
Atienza, D; Awasthi, S; Berry, W; Delaune, R; Deutsch, M; Dien, PY; Gregory, TF; Hood, K; Hutson, TE; Ilegbodu, D; Kolodziej, MJ; Mull, S; Muscato, JJ; Nicol, S; Raju, RN; Ruxer, RL; Vukelja, S	1
Asmar, L; Cohn, AL; Deur, C; Hood, K; Ilegbodu, D; Khan, MM; Mamus, S; Myers, JW; Nicol, S	1
de Jong, M; Krenning, EP; Müller, C; Schibli, R	1
Adachi, S; Fujimoto, T; Fukuoka, M; Ichinose, Y; Kubota, K; Nakagawa, K; Nambu, Y; Nishiwaki, Y; Ohe, Y; Saijo, N; Tamura, T; Yamamoto, N	1
Bearz, A; Pampaloni, G; Russo, F	1
Aghajanian, CA; Fury, M; Gerst, S; Goss, TL; Hensley, ML; Konner, J; Larkin, J; Orlando, M; Sabbatini, P; Tai, DF	1
Bromund, JL; Chen, R; Neubauer, M; Obasaju, C; Raju, RN; Reynolds, CH; Richards, DA; Ruxer, RL; Savin, M; Smith, DA; Socinski, MA; Zhan, F	1
Latz, JE; Miller, MA; Nakagawa, K; Schneck, KL; Takimoto, CH	1
Arpin, D; Biron, E; Cadranel, J; Duruisseaux, M; Guérin, JC; Pérol, M	1
Cerny, T; D'Addario, G; Früh, M; Gillessen, S; Omlin, A; von Hessling, A	1
Bosch-Barrera, J; Ceballos, J; Ferrer, M; García-Foncillas, J; Gaztañaga, M; Gil-Bazo, I; Idoate, MA; López-Picazo, JM; Pérez-Gracia, JL; Pretel, M; Sanz, ML	1
Barata, F; Barlesi, F; Bearz, A; Bepler, G; Chiappori, A; Chouaki, N; Iscoe, N; Liepa, AM; Park, K; Reck, M; Scagliotti, G; Soria, JC; von Pawel, J; Wagle, A; Zhao, YD	1
Bhargava, P; Casey, C; Chan, JA; Clark, JW; Earle, CC; Kulke, MH; Regan, E; Stuart, K; Zhu, AX	1
Leamon, CP; Müller, C; Reddy, JA; Schibli, R	1
Chang, MH; Diop-Bove, N; Fulterer, A; Goldman, ID; Mahadeo, K; Romero, MF; Shin, D; Teo, J; Unal, ES; Zhao, R	1
Ametamey, SM; Groehn, V; Honer, M; Müller, C; Ross, TL; Schibli, R	1
Leamon, CP; Müller, C; Santhapuram, HK; Schibli, R; Vlahov, IR	1
Batey, RT; Ceres, P; Reyes, FE; Trausch, JJ	1
Fiser, A; Goldman, ID; Shin, DS; Yap, EH; Zhao, R	1
Kamen, BA; Smith, AK	1
Sahoo, SK; Vandana, M	1
Desmoulin, SK; Gangjee, A; Hou, Z; Matherly, LH	1
Arora, JS; Blair, IA; Hammons, AL; Jochems, J; Summers, CM; Whitehead, AS; Zhang, S	1
Igawa, S; Katono, K; Maki, S; Masuda, N; Otani, S; Ryuge, S; Sasaki, J; Sato, Y; Takakura, A; Wada, M	1
Araújo, JR; Correia-Branco, A; Keating, E; Martel, F; Moreira, L; Ramalho, C	1
Barlow, N; Chhabra, S; Dolezal, O; Graham, B; Hattarki, MK; Newman, J; Peat, TS; Swarbrick, JD	1
Ensafi, AA; Kadivar, M; Mirmoghtadaie, L; Norouzi, P	1
Azevedo, E; Kameo, SY; Martins-Filho, PR; Mascarenhas-Oliveira, AC; Vieira, NF	1
Chang, GC; Chiu, LY; Hsu, SL; Huang, YR; Sheu, GT; Yang, TY	1
Haller, S; Leamon, CP; Müller, C; Reber, J	1
Diop-Bove, N; Goldman, ID; Zhao, R	1
Hou, Z; Matherly, LH; Wilson, MR	1
Amoroso, MR; Costi, MP; D'Arca, D; Esposito, F; Genovese, F; Gualandi, A; Guerrini, R; Marraccini, C; Martello, A; Marverti, G; Pelà, M; Perco, P; Pirondi, S; Ponterini, G; Taddia, L	1
Maiti, TK; Mohapatra, S; Narayan, R; Rout, SR	1
Hosomi, Y; Iguchi, M; Nagamata, M; Nakahara, Y; Okamoto, H; Okamura, T; Okuma, Y; Shibuya, M; Shimokawa, T; Sunami, K; Takagi, Y; Yomota, M	1
Baell, JB; Barlow, N; Chhabra, S; Cleary, B; Debono, A; Dennis, ML; Dolezal, O; Graham, B; Hattarki, M; Newman, J; Peat, TS; Pitcher, NP; Rahmani, R; Swarbrick, JD; Wang, ZC	1
Fiser, A; Goldman, ID; Najmi, M; Unal, ES; Visentin, M; Zhao, R	1
Horai, T; Horiike, A; Kudo, K; Nishio, M; Ohyanagi, F; Saito, R; Sakatani, T; Tanaka, H; Yanagitani, N	1
Goldman, ID; Visentin, M; Zhao, R	1
Chohnabayashi, N; Gotoh, K; Jinta, T; Kitamura, A; Koyama, K; Nishimura, N; Ohde, S; Okafuji, K; Takayama, S; Tomishima, Y; Tsuda, Y; Yagi, N	1
Kovalev, VI; Vekshin, NL	1
Furtado, I; Nery, FG; Valadares, D	1
de Rouw, N; Derijks, HJ; Piet, B; Ter Heine, R; van den Heuvel, MM	1

Reviews

23 review(s) available for folic acid and guanine

Article	Year
Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Acyltransferases; Animals; Antineoplastic Agents; Drug Design; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Indicators and Reagents; Molecular Structure; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Pyrroles; Quinazolines; Structure-Activity Relationship; Tetrahydrofolates	1993
Folate-based thymidylate synthase inhibitors as anticancer drugs. Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:9 Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1995
An overview of folate metabolism: features relevant to the action and toxicities of antifolate anticancer agents. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed; Thymidylate Synthase	1999
Thymidylate synthase inhibitors. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1999
Thymidylate synthase inhibitors in colorectal cancer. Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10 Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	2000
Folate status and the safety profile of antifolates. Seminars in oncology, 2002, Volume: 29, Issue:2 Suppl 5 Topics: Antimetabolites, Antineoplastic; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Thymidylate Synthase; Vitamin B 12	2002
Phase I trials of pemetrexed. Seminars in oncology, 2002, Volume: 29, Issue:2 Suppl 5 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Dietary Supplements; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed	2002
Future directions in the development of pemetrexed. Seminars in oncology, 2002, Volume: 29, Issue:2 Suppl 5 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dietary Supplements; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Forecasting; Glutamates; Guanine; Humans; Neoplasms; Pemetrexed; Vitamin B 12	2002
Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors). Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 9 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Pleural Neoplasms; Thymidylate Synthase; Vitamin B 12	2002
Pemetrexed safety and dosing strategy. Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 18 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Homocysteine; Humans; Methylmalonic Acid; Neoplasms; Pemetrexed; Thymidylate Synthase; Vitamin B 12	2002
Pemetrexed in pancreatic cancer. Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 18 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Folic Acid; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Pancreatic Neoplasms; Pemetrexed; Thymidylate Synthase; Vitamin B 12	2002
Pemetrexed in gastric cancer: clinical experience and future perspectives. Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 18 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed; Stomach Neoplasms; Thymidylate Synthase	2002
Pharmacology and mechanism of action of pemetrexed. Clinical lung cancer, 2004, Volume: 5 Suppl 2 Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Glutamates; Guanine; Humans; Molecular Structure; Pemetrexed; Renal Insufficiency	2004
Pemetrexed alone and in combination with platinum compounds in the management of malignant mesothelioma. Clinical lung cancer, 2004, Volume: 5 Suppl 2 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Hematinics; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Vitamin B 12	2004
Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 2 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasms; Pemetrexed; Platinum Compounds; Thymidylate Synthase; Vitamin B 12	2004
Pemetrexed in advanced NSCLC: a review of the clinical data. Oncology (Williston Park, N.Y.), 2004, Volume: 18, Issue:8 Suppl 5 Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Dietary Supplements; Folic Acid; Glutamates; Guanine; Hematinics; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Thymidylate Synthase; Vitamin B 12	2004
FDA drug approval summaries: pemetrexed (Alimta). The oncologist, 2004, Volume: 9, Issue:5 Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Clinical Trials, Phase III as Topic; Drug Approval; Folic Acid; Glutamates; Guanine; Humans; Infusions, Intravenous; Mesothelioma; Pemetrexed; United States; United States Food and Drug Administration; Vitamin B 12	2004
Antimetabolites in the management of non-small cell lung cancer. Current treatment options in oncology, 2005, Volume: 6, Issue:1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Survival; Treatment Outcome	2005
Cytotoxic anticancer agents and renal impairment study: the challenge remains. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Feb-01, Volume: 24, Issue:4 Topics: Antimetabolites, Antineoplastic; Drug Administration Schedule; Folic Acid; Glomerular Filtration Rate; Glutamates; Guanine; Humans; Kidney Failure, Chronic; Neoplasms; Pemetrexed; Vitamin B 12	2006
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Molecular cancer therapeutics, 2007, Volume: 6, Issue:2 Topics: Antimetabolites, Antineoplastic; Biological Transport; Clinical Trials as Topic; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Neoplasms; Pemetrexed	2007
The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed. Cancer metastasis reviews, 2007, Volume: 26, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Transport; Cloning, Molecular; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Intestinal Mucosa; Membrane Transport Proteins; Pemetrexed	2007
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer biology & therapy, 2012, Volume: 13, Issue:14 Topics: Biological Transport; Carcinoma, Non-Small-Cell Lung; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Molecular Targeted Therapy; Neoplasms; Pemetrexed; Proton-Coupled Folate Transporter	2012
Mechanisms, Management and Prevention of Pemetrexed-Related Toxicity. Drug safety, 2021, Volume: 44, Issue:12 Topics: Folic Acid; Glutamates; Guanine; Humans; Leucovorin; Neutropenia; Pemetrexed	2021

Trials

20 trial(s) available for folic acid and guanine

Article	Year
Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Apr-15, Volume: 21, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Folic Acid; Folic Acid Antagonists; Follow-Up Studies; Glutamates; Guanine; Hematinics; Humans; Leukopenia; Male; Mesothelioma; Middle Aged; Neutropenia; Pemetrexed; Pleural Neoplasms; Survival Analysis; Treatment Outcome	2003
Phase II study of pemetrexed disodium (Alimta) administered with oral folic acid in patients with advanced gastric cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:10 Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Female; Folic Acid; Glutamates; Guanine; Hematinics; Humans; Infusions, Intravenous; Male; Middle Aged; Neutropenia; Pemetrexed; Stomach Neoplasms; Treatment Outcome	2003
A phase II trial of pemetrexed in patients with metastatic renal cancer. Investigational new drugs, 2003, Volume: 21, Issue:3 Topics: Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Glutamates; Guanine; Hematinics; Humans; Infusions, Intravenous; Kidney Neoplasms; Male; Middle Aged; Pemetrexed; Time Factors; Treatment Outcome; Vitamin B 12	2003
FDA drug approval summaries: pemetrexed (Alimta). The oncologist, 2004, Volume: 9, Issue:5 Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Clinical Trials, Phase III as Topic; Drug Approval; Folic Acid; Glutamates; Guanine; Humans; Infusions, Intravenous; Mesothelioma; Pemetrexed; United States; United States Food and Drug Administration; Vitamin B 12	2004
Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Feb-01, Volume: 24, Issue:4 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Administration Schedule; Fatigue; Female; Folic Acid; Glutamates; Guanine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nausea; Neoplasms; Neutropenia; Pemetrexed; Thrombocytopenia; Vitamin B 12	2006
A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. British journal of cancer, 2006, Sep-18, Volume: 95, Issue:6 Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Glutamates; Guanine; Humans; Infusions, Intravenous; Japan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Pemetrexed; Safety; Treatment Outcome; Vitamin B 12	2006
Phase II trial of pemetrexed as second-line therapy in patients with metastatic urothelial carcinoma. Investigational new drugs, 2007, Volume: 25, Issue:3 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Carcinoma, Transitional Cell; Drug Administration Schedule; Folic Acid; Glutamates; Guanine; Humans; Infusions, Intravenous; Pelvic Neoplasms; Pemetrexed; Salvage Therapy; Treatment Outcome; Urethral Neoplasms; Urinary Bladder Neoplasms; Urothelium; Vitamin B 12; Vitamin B Complex	2007
Pemetrexed in patients with locally advanced or metastatic breast cancer who had received previous anthracycline and taxane treatment: phase II study. Clinical breast cancer, 2006, Volume: 7, Issue:5 Topics: Adult; Aged; Anthracyclines; Antineoplastic Agents; Breast Neoplasms; Bridged-Ring Compounds; Female; Folic Acid; Glutamates; Guanine; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pemetrexed; Premedication; Salvage Therapy; Taxoids; Vitamin B 12; Vitamin B Complex	2006
Phase I and pharmacokinetic study of pemetrexed with high-dose folic acid supplementation or multivitamin supplementation in patients with locally advanced or metastatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Dietary Supplements; Female; Folic Acid; Glutamates; Guanine; Humans; Infusions, Parenteral; Male; Neoplasm Metastasis; Neoplasms; Pemetrexed; Vitamin B Complex	2007
A randomized, double-blind, phase II study of two doses of pemetrexed as first-line chemotherapy for advanced breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jun-15, Volume: 13, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Breast Neoplasms; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Gene Expression; Glutamates; Guanine; Humans; Middle Aged; Pemetrexed; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vitamin B 12	2007
Pemetrexed and oxaliplatin for metastatic colorectal cancer: results of a phase I Mayo Cancer Center Research Consortium trial, MC0248. Clinical colorectal cancer, 2007, Volume: 6, Issue:8 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Survival Rate; Treatment Outcome; Vitamin B 12	2007
Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules. British journal of cancer, 2007, Oct-22, Volume: 97, Issue:8 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Deoxyuridine; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Lung Neoplasms; Male; Methylmalonic Acid; Middle Aged; Pemetrexed; Thymidine; Thymidylate Synthase; Vinblastine; Vinorelbine; Vitamin B 12	2007
Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium. Investigational new drugs, 2008, Volume: 26, Issue:2 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Female; Folic Acid; Gemcitabine; Glutamates; Guanine; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Pemetrexed; Treatment Outcome; Urinary Bladder Neoplasms; Urothelium; Vitamin B 12; Vitamin B Complex	2008
A phase II study of pemetrexed in patients with advanced hepatocellular carcinoma. Investigational new drugs, 2008, Volume: 26, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Dexamethasone; Disease Progression; Female; Folic Acid; Glutamates; Guanine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pemetrexed; Survival Rate; Treatment Outcome; Vitamin B 12	2008
Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jul-01, Volume: 14, Issue:13 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Regression Analysis; Safety; Treatment Outcome; Vitamin B 12	2008
A phase I trial of pemetrexed plus gemcitabine given biweekly with B-vitamin support in solid tumor malignancies or advanced epithelial ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Oct-01, Volume: 14, Issue:19 Topics: Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Deoxycytidine; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Gemcitabine; Glutamates; Guanine; Humans; Maximum Tolerated Dose; Neoplasms; Neutropenia; Ovarian Neoplasms; Pemetrexed; Treatment Outcome; Vitamin B Complex	2008
Pemetrexed in relapsed small-cell lung cancer and the impact of shortened vitamin supplementation lead-in time: results of a phase II trial. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2008, Volume: 3, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cohort Studies; Dietary Supplements; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pemetrexed; Prognosis; Salvage Therapy; Small Cell Lung Carcinoma; Survival Rate; Thymidylate Synthase; Vitamin B Complex	2008
Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Double-Blind Method; Female; Folic Acid; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pemetrexed; Prognosis; Salvage Therapy; Survival Rate; Vitamin B 12	2010
Phase II study of pemetrexed in patients with advanced neuroendocrine tumors. Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:5 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dexamethasone; Female; Folic Acid; Glutamates; Guanine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neuroendocrine Tumors; Pemetrexed; Survival; Treatment Outcome; Vitamin B 12; Vitamin B Complex	2010
A prospective study of shortened vitamin supplementation prior to cisplatin-pemetrexed therapy for non-small cell lung cancer. The oncologist, 2014, Volume: 19, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Pemetrexed; Prospective Studies; Treatment Outcome; Vitamin B 12	2014

Other Studies

73 other study(ies) available for folic acid and guanine

Article	Year
Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells. Biochimica et biophysica acta, 1990, Jun-20, Volume: 1034, Issue:3 Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Bone Marrow; Carbon; Deoxyadenosines; Folic Acid; Formates; Glycine; Guanine; Male; Methionine; Methionine Adenosyltransferase; Oxidation-Reduction; Rats; Rats, Inbred Strains; Serine; Thionucleosides	1990
Biosynthesis of biopterin by Chinese hamster ovary (CHO K1) cell culture. The Journal of biological chemistry, 1974, Jul-25, Volume: 249, Issue:14 Topics: Animals; Anura; Biological Assay; Carbon Radioisotopes; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cricetinae; Culture Media; Drosophila melanogaster; Eukaryota; Female; Folic Acid; Guanine; Guanine Nucleotides; Guanosine; Mice; Models, Chemical; Neuroblastoma; Ovary; Pteridines; Pterins; Purine Nucleotides; RNA; Structure-Activity Relationship	1974
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma. Cancer research, 1973, Volume: 33, Issue:9 Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Formates; Glycine; Guanine; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Rats; Serine; Thymidine; Vitamin B 12	1973
The sites of action of allopurinol in Crithidia fasciculata. The Journal of protozoology, 1973, Volume: 20, Issue:5 Topics: Adenine; Allopurinol; Animals; Carbon Radioisotopes; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Paper; Colorimetry; Cytosine; Dose-Response Relationship, Drug; Eukaryota; Folic Acid; Guanine; Hypoxanthines; Orotic Acid; Pentosyltransferases; Pterins; Spectrophotometry; Uracil; Xanthines	1973
Evidence against the folate-mediated formylation of formyl-accepting methionyl transfer ribonucleic acid in Streptococcus faecalis R. The Journal of biological chemistry, 1970, Oct-10, Volume: 245, Issue:19 Topics: Adenine; Aminopterin; Bacterial Proteins; Culture Media; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Formates; Guanine; Methionine; Pyrimidines; RNA, Transfer; Serine; Thymine	1970
Purine requirement of cells cultured from humans affected with Lesch-Nyhan syndrome (hypoxanthine-guanine phosphoribosyltransferase deficiency). Proceedings of the National Academy of Sciences of the United States of America, 1969, Volume: 62, Issue:2 Topics: Adenine; Clone Cells; Culture Techniques; Female; Folic Acid; Guanine; Humans; Hypoxanthines; Phenotype; Purine-Pyrimidine Metabolism, Inborn Errors; Sex Chromosome Aberrations; Transferases	1969
The effect of sulphoguanidine and p-nitrobenzoic acid on the chromosome breakage-reunion process by gamma-, x- and beta-irradiation in Vicia faba. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1966, Volume: 10, Issue:4 Topics: Aminobenzoates; Arginine; Chloramphenicol; Chromosomes; Dinitrophenols; Folic Acid; Guanidines; Guanine; Histidine; Nitrobenzenes; Plants; Radiation Effects; Radiation-Sensitizing Agents	1966
Lactobacillus jensenii sp.nov., a new representative of the subgenus Thermobacterium. Journal of general microbiology, 1970, Volume: 62, Issue:2 Topics: Cytosine; DNA, Bacterial; Electrophoresis; Folic Acid; Guanine; L-Lactate Dehydrogenase; Lactobacillus; Monosaccharides; Nicotinic Acids; Phenotype; Vitamin B 12	1970
Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney. Cancer research, 1983, Volume: 43, Issue:3 Topics: Animals; DNA (Cytosine-5-)-Methyltransferases; Female; Folic Acid; Guanine; Kidney; Liver; Male; Methyltransferases; Nephrectomy; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains; Sex Factors	1983
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. British journal of cancer, 1998, Volume: 78 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Nucleotides; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1998
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured	1999
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Prostaglandins A	2000
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Cancer research, 2001, May-01, Volume: 61, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase	2001
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. I. Growth studies. Journal of the National Cancer Institute, 1970, Volume: 44, Issue:1 Topics: Adenine; Adenosine; Animals; Cell Division; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Folic Acid; Guanine; Mice; Nucleic Acid Precursors; Nucleosides; Pyrimidines; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12	1970
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2002
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Molecular cancer therapeutics, 2002, Volume: 1, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Models, Biological; Multivariate Analysis; Odds Ratio; Pemetrexed; Time Factors; Vitamin B 12	2002
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochemical pharmacology, 2003, Apr-01, Volume: 65, Issue:7 Topics: Animals; Biological Transport; Carrier Proteins; Down-Regulation; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Gene Silencing; Glutamates; Guanine; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Membrane Transport Proteins; Mice; Pemetrexed; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Reduced Folate Carrier Protein; Tumor Cells, Cultured	2003
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thrombosis research, 2003, May-01, Volume: 110, Issue:2-3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine; Case-Control Studies; Coronary Disease; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Guanine; Homocysteine; Humans; Middle Aged; Osmolar Concentration; Risk Factors; Vitamin B 12	2003
Combination chemotherapy of cancer: potentiation of carcinostatic activity of 8-azaguanine by 6-formylpteridine. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1952, Volume: 81, Issue:3 Topics: Animals; Antimetabolites; Azaguanine; Drug Therapy, Combination; Folic Acid; Guanine; Neoplasms; Neoplasms, Experimental	1952
Deazapteridines and deazapurines, inhibitory analogues of folic acid and guanine. The Journal of biological chemistry, 1958, Volume: 231, Issue:1 Topics: Folic Acid; Folic Acid Antagonists; Guanine; Humans; Organic Chemicals	1958
THE BIOSYNTHESIS OF FOLIC ACID. IV. ENZYMATIC SYNTHESIS OF DIHYDROFOLIC ACID FROM GUANINE AND RIBOSE COMPOUNDS. The Journal of biological chemistry, 1964, Volume: 239 Topics: Carbon Isotopes; Chromatography; Enterococcus faecalis; Escherichia coli; Folic Acid; Glucosephosphate Dehydrogenase; Guanine; Hexokinase; Metabolism; Nucleosides; Oxidoreductases; Pentosephosphates; Pterins; Research; Ribose	1964
FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Guanine; Metabolism; Methotrexate; Mutation; Purines; Research; Serine; Thymine; Xanthines	1964
REPRESSION BY ADENINE OF THE FORMYLTETRAHYDROFOLATE SYNTHETASE IN AN ANTIFOLIC-RESISTANT MUTANT OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Bacteriological Techniques; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Formate-Tetrahydrofolate Ligase; Guanine; Ligases; Methotrexate; Mutation; Purines; Research; Tetrahydrofolate Dehydrogenase; Thymine	1964
DEVELOPMENT AND PROPERTIES OF MOUSE LEUKEMIA L1210 RESISTANT TO MIRACIL D. Cancer research, 1964, Volume: 24 Topics: Adenine; Animals; Azaguanine; Cyclophosphamide; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Leucovorin; Leukemia L1210; Lucanthone; Mercaptopurine; Methotrexate; Mice; Pharmacology; Proadifen; Pyridoxine; Research; Thioguanine	1964
METHYLATED PURINES AND PYRIMIDINES. II. SYNTHESIS AND PROPERTIES OF 2,6-DIAMINO-5-(METHYLAMINO)-4-PYRIMIDINOL. Biochemistry, 1965, Volume: 4 Topics: Alkylation; Chemical Phenomena; Chemistry; Folic Acid; Glutamates; Guanine; Pterins; Purines; Pyrimidines; Research	1965
Enzymatic formation of the pteridine moiety of folic acid from guanine compounds. The Journal of biological chemistry, 1962, Volume: 237 Topics: Folic Acid; Guanine; Humans; Nucleosides; Nucleotides; Pteridines; Pterins	1962
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-01, Volume: 10, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors	2004
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-15, Volume: 10, Issue:18 Pt 1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate	2004
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-01, Volume: 10, Issue:23 Topics: Apoptosis; Base Sequence; Blotting, Northern; Carrier Proteins; Fluorescent Antibody Technique; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Formyltetrahydrofolates; Glutamates; Guanine; HeLa Cells; Humans; Molecular Sequence Data; Neoplasms; Pemetrexed; Receptors, Cell Surface; RNA Interference; Thymidylate Synthase; Tumor Cells, Cultured	2004
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24 Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Methotrexate; Pemetrexed; Receptors, Cell Surface; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors	2004
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Feb-01, Volume: 11, Issue:3 Topics: Animals; Blotting, Western; Cattle; Cell Division; Cell Line, Tumor; Culture Media; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hypoxanthine; Leucovorin; Membrane Transport Proteins; Pemetrexed; Purines; Reduced Folate Carrier Protein; Serum; Thymidylate Synthase; Thymine	2005
Pemetrexed: a new cytotoxic agent in the development for first-line non-small-cell lung cancer. Lung cancer (Amsterdam, Netherlands), 2005, Volume: 50 Suppl 1 Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Vitamin B 12	2005
A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:4 Topics: Adult; Aged; Algorithms; Analysis of Variance; Antimetabolites, Antineoplastic; Area Under Curve; Avitaminosis; Blood Cell Count; Body Surface Area; Clinical Trials, Phase II as Topic; Data Interpretation, Statistical; Female; Folic Acid; Glutamates; Guanine; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Models, Statistical; Neutropenia; Neutrophils; Pemetrexed; Population; Vitamin B 12; Vitamin B 6; Vitamins	2006
Design, conduct, and interpretation of organ impairment studies in oncology patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-20, Volume: 24, Issue:21 Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dietary Supplements; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Glomerular Filtration Rate; Glutamates; Guanine; Humans; Kidney; Pemetrexed; Research Design	2006
Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis. Applied and environmental microbiology, 2007, Volume: 73, Issue:8 Topics: 4-Aminobenzoic Acid; Adenine; Folic Acid; Gene Deletion; Genes, Bacterial; Guanine; Inosine; Lactococcus lactis; Metabolic Networks and Pathways; Models, Biological; Xanthine	2007
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. The oncologist, 2007, Volume: 12, Issue:7 Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colorectal Neoplasms; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; In Vitro Techniques; Lung Neoplasms; Mesothelioma; Pemetrexed; Tetrahydrofolates	2007
Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors. Nuclear medicine and biology, 2007, Volume: 34, Issue:6 Topics: Animals; Antineoplastic Agents; Buffers; Carrier Proteins; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Isotope Labeling; KB Cells; Kidney; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Pemetrexed; Phosphates; Radioisotopes; Radiopharmaceuticals; Receptors, Cell Surface; Rhenium; Technetium; Tissue Distribution	2007
Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. Cancer research, 2007, Sep-15, Volume: 67, Issue:18 Topics: Base Sequence; Cytosol; Exons; Folic Acid; Folic Acid Antagonists; Genetic Variation; Glutamates; Guanine; Haplotypes; Humans; Kinetics; Methotrexate; Pemetrexed; Peptide Synthases; Polymorphism, Single Nucleotide; Substrate Specificity	2007
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21 Topics: Antineoplastic Agents, Alkylating; Carmustine; Carrier Proteins; Cell Line, Tumor; Deoxyguanosine; Drug Resistance, Neoplasm; Esters; Folate Receptors, GPI-Anchored; Folic Acid; Guanine; Humans; Hydrolysis; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Cell Surface; Solubility; Structure-Activity Relationship	2007
Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells. Molecular cancer therapeutics, 2007, Volume: 6, Issue:11 Topics: Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Folic Acid; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Methotrexate; Pemetrexed; Peptide Synthases; Polyglutamic Acid; RNA, Small Interfering; Transfection	2007
Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptor-positive ovarian cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:4 Topics: Animals; Autoradiography; Carrier Proteins; Cell Line, Tumor; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indium Radioisotopes; Kidney; Mice; Ovarian Neoplasms; Pemetrexed; Pentetic Acid; Receptors, Cell Surface; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed	2008
Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer. BMC cancer, 2008, Jul-31, Volume: 8 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dexamethasone; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pemetrexed; Vitamin B 12	2008
Population pharmacokinetic/pharmacodynamic analyses of pemetrexed and neutropenia: effect of vitamin supplementation and differences between Japanese and Western patients. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jan-01, Volume: 15, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Dietary Supplements; Female; Folic Acid; Glutamates; Guanine; Humans; Male; Middle Aged; Neutropenia; Pemetrexed; Time Factors; Vitamin B 12; White People	2009
Major and prolonged response to pemetrexed in two cases of lung adenocarcinoma with bronchioloalveolar carcinoma features. Lung cancer (Amsterdam, Netherlands), 2009, Volume: 65, Issue:3 Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Aged; Antimetabolites, Antineoplastic; Bone Neoplasms; Cough; Disease Progression; Dyspnea; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Neoplasm Staging; Neutropenia; Pemetrexed; Remission Induction; Renal Insufficiency; Smoking; Tomography, X-Ray Computed; Vitamin B 12	2009
Activity of pemetrexed against brain metastases in a patient with adenocarcinoma of the lung. Lung cancer (Amsterdam, Netherlands), 2009, Volume: 65, Issue:3 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Brain Neoplasms; Chest Pain; Disease Progression; Dyspnea; Female; Folic Acid; Glutamates; Guanine; Headache; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Pemetrexed; Radiotherapy; Remission Induction; Smoking; Thoracic Surgery; Vitamin B 12	2009
Toxic epidermal necrolysis related to pemetrexed and carboplatin with vitamin B12 and folic acid supplementation for advanced non-small cell lung cancer. Onkologie, 2009, Volume: 32, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Stevens-Johnson Syndrome; Vitamin B 12	2009
Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice. Molecular pharmaceutics, 2010, Apr-05, Volume: 7, Issue:2 Topics: Animals; Cell Line, Tumor; Female; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kidney; Mice; Mice, Nude; Oligopeptides; Organotechnetium Compounds; Pemetrexed; Quinazolines; Technetium; Xenograft Model Antitumor Assays	2010
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:5 Topics: Amino Acid Substitution; Animals; Arginine; Folic Acid; Folic Acid Antagonists; Glutamates; Glutamine; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Malabsorption Syndromes; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Pemetrexed; Proton-Coupled Folate Transporter; Protons; Tetrahydrofolates; Xenopus laevis	2010
A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:11 Topics: Animals; Biological Transport; Fluorine Radioisotopes; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Hydrophobic and Hydrophilic Interactions; KB Cells; Kidney; Ligands; Mice; Neoplasms; Pemetrexed; Positron-Emission Tomography; Radiochemistry; Staining and Labeling; Substrate Specificity	2010
Tumor targeting using 67Ga-DOTA-Bz-folate--investigations of methods to improve the tissue distribution of radiofolates. Nuclear medicine and biology, 2011, Volume: 38, Issue:5 Topics: Animals; Biological Transport; Female; Folic Acid; Folic Acid Antagonists; Gallium Radioisotopes; Glutamates; Guanine; Half-Life; Heterocyclic Compounds; Humans; Hydrogen-Ion Concentration; Injections; Isothiocyanates; KB Cells; Kidney; Mice; Pemetrexed; Radioactive Tracers; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Urine; Uterine Cervical Neoplasms	2011
The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer. Structure (London, England : 1993), 2011, Oct-12, Volume: 19, Issue:10 Topics: Aptamers, Nucleotide; Bacillus subtilis; Bacterial Proteins; Base Sequence; Binding Sites; Calorimetry; Folic Acid; Gene Expression Regulation, Bacterial; Guanine; Leucovorin; Ligands; Magnesium; Molecular Sequence Data; Nucleic Acid Conformation; Point Mutation; Protein Binding; Protein Structure, Secondary; Riboswitch; RNA; S-Adenosylmethionine; Streptococcus mutans; Terminator Regions, Genetic; Tetrahydrofolates; Thermodynamics; Transcription, Genetic	2011
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. American journal of physiology. Cell physiology, 2012, May-01, Volume: 302, Issue:9 Topics: Antineoplastic Agents; Blotting, Western; Cells, Cultured; Folic Acid; Glutamates; Guanine; Humans; Immunoprecipitation; Malabsorption Syndromes; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Pemetrexed; Protein Binding; Protein Structure, Secondary; Proton-Coupled Folate Transporter; Transfection	2012
Farletuzumab, an anti-folate receptor α antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro. Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:1 Topics: Animals; Antibodies, Monoclonal, Humanized; Binding, Competitive; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Folate Receptor 1; Folic Acid; Glutamates; Guanine; Humans; Kinetics; Pemetrexed; Tetrahydrofolates; Tritium	2012
Reduced folate carrier independent internalization of PEGylated pemetrexed: a potential nanomedicinal approach for breast cancer therapy. Molecular pharmaceutics, 2012, Oct-01, Volume: 9, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Female; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nanomedicine; Pemetrexed; Polyethylene Glycols; Reduced Folate Carrier Protein; S Phase	2012
Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions. European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3 Topics: Cell Line; Chemokine CCL2; Complement C3; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inflammation; Interleukin-8; Pemetrexed; Phenotype; RNA, Messenger; Tetrahydrofolate Dehydrogenase	2012
Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression. Chemotherapy, 2012, Volume: 58, Issue:4 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leukopenia; Lung Neoplasms; Male; Middle Aged; Nausea; Neutropenia; Pemetrexed; Salvage Therapy; Thrombocytopenia; Thymidylate Synthase; Treatment Outcome	2012
Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α. Pediatric research, 2013, Volume: 73, Issue:4 Pt 1 Topics: Adult; Biological Transport; Case-Control Studies; Cells, Cultured; Diabetes, Gestational; Female; Folic Acid; Glutamates; Guanine; Humans; Hydrogen-Ion Concentration; Inflammation Mediators; Kinetics; Leptin; Lipopolysaccharides; Pemetrexed; Pregnancy; Proton-Coupled Folate Transporter; Recombinant Proteins; Signal Transduction; Tetrahydrofolates; Trophoblasts; Tumor Necrosis Factor-alpha	2013
Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK. PloS one, 2013, Volume: 8, Issue:4 Topics: Binding Sites; Biosynthetic Pathways; Diphosphotransferases; Drug Design; Enzyme Inhibitors; Folic Acid; Guanine; Ligands; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Thermodynamics	2013
Highly selective electrochemical biosensor for the determination of folic acid based on DNA modified-pencil graphite electrode using response surface methodology. Materials science & engineering. C, Materials for biological applications, 2013, Apr-01, Volume: 33, Issue:3 Topics: Adenine; Analysis of Variance; Biosensing Techniques; Calibration; DNA; Electrochemistry; Electrodes; Flour; Folic Acid; Graphite; Guanine; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Statistics as Topic; Triticum	2013
Pemetrexed-induced eyelid edema in lung cancer. The Journal of craniofacial surgery, 2013, Volume: 24, Issue:4 Topics: Adenocarcinoma; Antineoplastic Agents; Brain Neoplasms; Carboplatin; Dexamethasone; Diuretics; Edema; Eyelid Diseases; Female; Folic Acid; Furosemide; Glucocorticoids; Glutamates; Guanine; Humans; Lung Neoplasms; Middle Aged; Pemetrexed; Vitamin B 12	2013
Effect of folic acid and vitamin B12 on pemetrexed antifolate chemotherapy in nutrient lung cancer cells. BioMed research international, 2013, Volume: 2013 Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dietary Supplements; Drug Screening Assays, Antitumor; Fluorouracil; Folic Acid; Folic Acid Antagonists; G1 Phase; Glutamates; Guanine; Humans; Lung Neoplasms; Neoplasm Proteins; Pemetrexed; Protein Stability; Serum; Treatment Outcome; Vitamin B 12	2013
177Lu-EC0800 combined with the antifolate pemetrexed: preclinical pilot study of folate receptor targeted radionuclide tumor therapy. Molecular cancer therapeutics, 2013, Volume: 12, Issue:11 Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Coordination Complexes; Drug Evaluation, Preclinical; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; KB Cells; Lutetium; Male; Mice; Mice, Nude; Neoplasms, Experimental; Pemetrexed; Pilot Projects; Radioisotopes; Radiopharmaceuticals; Xenograft Model Antitumor Assays	2013
Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression. Molecular pharmacology, 2014, Volume: 85, Issue:2 Topics: Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Endocytosis; Folic Acid; Folic Acid Antagonists; Folic Acid Transporters; Glutamates; Guanine; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Vinblastine	2014
Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. The Journal of biological chemistry, 2014, Sep-05, Volume: 289, Issue:36 Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biological Transport; Biotinylation; Blotting, Western; Cell Membrane; Cysteine; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Kinetics; Methotrexate; Molecular Sequence Data; Mutation; Pemetrexed; Protein Structure, Secondary; Proton-Coupled Folate Transporter; Tritium	2014
Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides. Journal of proteome research, 2014, Nov-07, Volume: 13, Issue:11 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Computational Biology; Female; Folic Acid; Glutamates; Guanine; Humans; Mass Spectrometry; Molecular Targeted Therapy; Ovarian Neoplasms; Pemetrexed; Peptides; Proteins; Reproducibility of Results; Thymidylate Synthase	2014
Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging. Dalton transactions (Cambridge, England : 2003), 2014, Nov-14, Volume: 43, Issue:42 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Cobalt; Ferrous Compounds; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Guanine; HeLa Cells; Humans; Magnetic Phenomena; Magnetic Resonance Imaging; Mice; Nanocapsules; NIH 3T3 Cells; Pemetrexed; Porosity; Silicon Dioxide	2014
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. Journal of medicinal chemistry, 2014, Nov-26, Volume: 57, Issue:22 Topics: Adenosine Triphosphate; Catalysis; Catalytic Domain; Crystallography, X-Ray; Dihydropteroate Synthase; Diphosphotransferases; Folic Acid; Guanine; Ions; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Protein Binding; Protein Conformation; Pterins; Staphylococcus aureus; Structure-Activity Relationship; Surface Plasmon Resonance	2014
Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). American journal of physiology. Cell physiology, 2015, Apr-15, Volume: 308, Issue:8 Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biological Transport; Cell Line, Tumor; Folic Acid; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Methotrexate; Models, Molecular; Pemetrexed; Protein Structure, Tertiary; Proton-Coupled Folate Transporter; Tyrosine	2015
Plasma homocysteine levels and hematological toxicity in NSCLC patients after the first cycle of pemetrexed under folate supplementation. Anti-cancer drugs, 2015, Volume: 26, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Blood Platelets; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Leukocytes; Lung Neoplasms; Male; Middle Aged; Pemetrexed	2015
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis. Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:6 Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes	2015
[Safety of pemetrexed according to the duration of vitamin B12 and folic acid supplementation prior to the first dose of pemetrexed]. Gan to kagaku ryoho. Cancer & chemotherapy, 2015, Volume: 42, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Diarrhea; Dietary Supplements; Drug Combinations; Exanthema; Female; Folic Acid; Glutamates; Guanine; Humans; Lung Neoplasms; Male; Middle Aged; Neutropenia; Pemetrexed; Retrospective Studies; Vitamin B 12	2015
Nucleotide carriers for anti-tumour actinomycin antibiotics. Journal of biochemistry, 2016, Volume: 159, Issue:1 Topics: Adenine; Antibiotics, Antineoplastic; Caffeine; Dactinomycin; DNA; Drug Carriers; Fluorescent Dyes; Folic Acid; Guanine; Nucleotides; Thymine	2016
Acute hepatitis B virus infection and severe non-immune haemolytic anaemia: a rare relationship. BMJ case reports, 2017, Oct-24, Volume: 2017 Topics: Acetylcysteine; Acute Disease; Adult; Anemia, Hemolytic; Antiviral Agents; Female; Folic Acid; Guanine; Hepatitis B; Humans; Treatment Outcome; Vitamin B Complex; Vitamin K; Vitamins	2017

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