fentanyl has been researched along with u-50488 in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (33.33) | 18.7374 |
| 1990's | 28 (40.58) | 18.2507 |
| 2000's | 13 (18.84) | 29.6817 |
| 2010's | 4 (5.80) | 24.3611 |
| 2020's | 1 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A | 1 |
| Gintzler, AR; Xu, H | 2 |
| Lin, FS; Wang, CQ; Zhu, GY | 1 |
| Mueller, JL; Quock, RM | 1 |
| Dong, XW; Headley, PM; Parsons, CG | 1 |
| Headley, PM; Herrero, JF | 1 |
| Armstrong, RA; Rooney, KF; Sewell, RD | 1 |
| Mueller, J; Quock, RM | 1 |
| Dykstra, LA; Negus, SS; Picker, MJ | 3 |
| Negus, SS; Picker, MJ; Powell, KR | 1 |
| Cowan, A; Murray, CW | 1 |
| Buydens, P; Finné, E; Govaerts, J; Matton, A; Vanhaelst, L | 1 |
| Clarke, G; Davison, I; MacMillan, SJ; Wright, DM | 1 |
| Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ | 1 |
| Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H | 2 |
| Yaksh, TL | 1 |
| Berde, CB; Chang, HM; Holz, GG; Kream, RM; Steward, GF | 1 |
| France, CP; Snyder, AM; Woods, JH | 1 |
| Headley, PM; Parsons, CG | 2 |
| Cornfeldt, M; Fielding, S; Gorney, B; Locke, KW | 1 |
| Blake, JW; DeQuick, D; Kamerling, S; Tai, C; Tobin, T; Weckman, TJ; Wood, T | 1 |
| Dykstra, LA; Picker, MJ | 1 |
| Rooney, KF; Sewell, RD | 1 |
| Gaumann, DM; Lucas, DL; Tyce, GM; Yaksh, TL | 1 |
| Frey, HH | 1 |
| Dykstra, LA; Massie, CA | 1 |
| Dykstra, LA; Negus, SS | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Schulz, R | 1 |
| Donahoe, J; Kamerling, S; Tobin, T; Weckman, T | 1 |
| Dykstra, LA; Picker, M | 1 |
| Bardon, T; Pairet, M; Ruckebusch, Y | 1 |
| Pairet, M; Ruckebusch, Y | 1 |
| Headley, PM; Herrero, JF; Thorn, SA | 1 |
| Bardon, T; Roger, T; Ruckebusch, Y | 1 |
| Shi, GG; Wei, DS; Xu, SF | 1 |
| Mama, KR; Pascoe, PJ; Steffey, EP | 1 |
| Morgan, D; Picker, MJ | 1 |
| Gebhart, GF; Sengupta, JN; Su, X | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK | 1 |
| Picker, MJ; Smith, MA | 1 |
| Cao, XD; Cui, DF; Li, MY; Qi, ZW; Wu, GC; Xu, SF; Zhang, XL; Zhu, CB | 1 |
| Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH | 1 |
| Kishioka, S; Ko, MC; Woods, JH | 1 |
| Carter, BL; Conklin, CA; Tiffany, ST | 1 |
| Chen, J; Chen, LW; Chi, ZQ; Feng, YP; Xu, XJ; Zhou, DH | 1 |
| Baker, AK; Hoffmann, VL; Meert, TF | 2 |
| Hall, SF; Loh, HH; Mizoguchi, H; Nagase, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR; Wu, HE | 1 |
| Bolling, SF; McNish, R; Romano, MA; Seymour, EM; Traynor, JR | 1 |
| Gallantine, EL; Meert, TF | 1 |
| Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S | 1 |
| Ko, MC; Mukhopadhyay, P; Pascoe, JE; Rice, KC; Williams, KL; Woods, JH | 1 |
| Martin, KK; Stahlheber, BW; Stevens, CW | 1 |
| Bolte, C; Newman, G; Schultz, Jel J | 1 |
| Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD | 1 |
| Buzby, D; Friscia, M; Kacinko, SL; Logan, BK; Mohr, AL; Papsun, D | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
1 review(s) available for fentanyl and u-50488
| Article | Year |
|---|---|
Narcotic analgesics, their detection and pain measurement in the horse: a review.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Chromatography, Thin Layer; Cyclazocine; Ethylketocyclazocine; Etorphine; Fentanyl; Horses; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Radioimmunoassay; Receptors, Opioid | 1989 |
1 trial(s) available for fentanyl and u-50488
| Article | Year |
|---|---|
Comparative effects of mu and kappa opiate agonists on the cecocolic motility in the pony.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Catheterization, Central Venous; Cecum; Colon; Cross-Over Studies; Fentanyl; Gastrointestinal Motility; Horses; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
67 other study(ies) available for fentanyl and u-50488
| Article | Year |
|---|---|
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil | 1992 |
[Effects of microiontophoretically applied OMF and U-50488 on spontaneous discharges of respiration related units in the region of nucleus of solitary tract of rat].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Depression, Chemical; Electrophysiology; Female; Fentanyl; Iontophoresis; Male; Medulla Oblongata; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Respiration | 1992 |
Contrasting influences of 5-hydroxytryptamine receptors in nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; Mice, Inbred Strains; Nitrous Oxide; Pyrrolidines; Receptors, Serotonin; Sufentanil | 1992 |
Effects of intravenous mu and kappa opioid receptor agonists on sensory responses of convergent neurones in the dorsal horn of spinalized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Fentanyl; Hot Temperature; Male; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Physical Stimulation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
The effects of sham and full spinalization on the systemic potency of mu- and kappa-opioids on spinal nociceptive reflexes in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Decerebrate State; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Motor Neurons; Naloxone; Nociceptors; Pain; Physical Stimulation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Spinal Cord | 1991 |
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Fentanyl; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle, Smooth; Myenteric Plexus; Narcotics; Pertussis Toxin; Pyrrolidines; Sufentanil; Virulence Factors, Bordetella | 1991 |
Increased dopamine receptor sensitivity in the rat following acute administration of sufentanil, U50,488H and D-Ala2-D-Leu5-enkephalin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzazepines; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Fentanyl; In Vitro Techniques; Locomotion; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sufentanil; Tritium | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Fentanyl; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pyrrolidines; Sufentanil | 1991 |
Interactions between the discriminative stimulus effects of mu and kappa opioid agonists in the squirrel monkey.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Buprenorphine; Drug Interactions; Fentanyl; Learning; Male; Morphinans; Naloxone; Narcotics; Pentobarbital; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1991 |
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1991 |
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1991 |
The growth hormone secretory response to fentanyl in rat: an involvement of mu type receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Leucine; Fentanyl; Growth Hormone; Male; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Pentobarbital; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Differential activity of selective opioid agonists on hypothalamic magnocellular neuronal activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Female; Fentanyl; Hypothalamus; Lactation; Neurons; Oxytocin; Pregnancy; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasopressins | 1990 |
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Effects of kappa- and mu-selective opiate agonists on colonic temperature in normoglycaemic and streptozotocin-treated hyperglycaemic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Body Temperature; Colon; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fentanyl; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1990 |
Substance P release from knee joint afferent terminals: modulation by opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Capsaicin; Cats; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Hindlimb; Joints; Narcotics; Pyrrolidines; Reference Values; Sciatic Nerve; Substance P; Sufentanil | 1988 |
Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chick Embryo; Enkephalin, Methionine; Fentanyl; In Vitro Techniques; Morphine; Neurons, Afferent; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Substance P; Sufentanil | 1989 |
Analgesic effects of phencyclidine-like drugs in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alfentanil; Analgesia; Analgesics; Anesthetics; Animals; Anticonvulsants; Dextrorphan; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Fentanyl; Ketamine; Macaca mulatta; Phenazocine; Phencyclidine; Pyrrolidines | 1989 |
Hyperglycemia does not modify the pupillary effects of mu and kappa opiate agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Blood Glucose; Fentanyl; Half-Life; Hyperglycemia; Male; Mice; Morphine; Narcotics; Pupil; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Spinal antinociceptive actions of mu- and kappa-opioids: the importance of stimulus intensity in determining 'selectivity' between reflexes to different modalities of noxious stimulus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Decerebrate State; Electrophysiology; Fentanyl; Narcotics; Neurons; Nociceptors; Pain; Physical Stimulation; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1989 |
On the selectivity of intravenous mu- and kappa-opioids between nociceptive and non-nociceptive reflexes in the spinalized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthetics; Animals; Decerebrate State; Fentanyl; Injections; Morphine; Motor Neurons; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1989 |
Mu-opioid component of the ethylketocyclazocine (EKC) discriminative stimulus in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Kappa antagonist effects of buprenorphine in the rat drug-discrimination procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Buprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Fentanyl; Morphine; Perceptual Masking; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dopamine Agents; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ergolines; Fentanyl; Injections, Intraventricular; Male; Mice; Narcotics; Nociceptors; Pyrrolidines; Quinpirole; Reaction Time; Receptors, Dopamine; Sufentanil; Sulpiride | 1989 |
Opioids preserve the adrenal medullary response evoked by severe hemorrhage: studies on adrenal catecholamine and met-enkephalin secretion in halothane anesthetized cats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Anesthesia, Inhalation; Animals; Catecholamines; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Halothane; Hemorrhage; Pyrrolidines; Receptors, Opioid; Sufentanil | 1988 |
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1988 |
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1988 |
Kappa antagonist properties of buprenorphine in the shock titration procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Electroshock; Fentanyl; Male; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1988 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Dependence and cross-dependence in the guinea-pig myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Drug Tolerance; Fentanyl; Guinea Pigs; Male; Morphine Dependence; Muscle Contraction; Myenteric Plexus; Pertussis Toxin; Pyrrolidines; Virulence Factors, Bordetella | 1988 |
Dose related effects of the kappa agonist U-50, 488H on behaviour, nociception and autonomic response in the horse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autonomic Nervous System; Body Temperature; Chemical Phenomena; Chemistry; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Horses; Locomotion; Male; Nociceptors; Pupil; Pyrrolidines; Respiration | 1988 |
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors | 1987 |
Opioid control of the ruminant stomach motility: functional importance of mu, kappa and delta receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Ethylketocyclazocine; Fentanyl; Gastrointestinal Motility; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sheep; Stomach | 1984 |
Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Cyclazocine; Dynorphins; Electric Conductivity; Enkephalins; Ethylketocyclazocine; Fentanyl; Male; Morphine; Naloxone; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Stimulus intensity and the comparative efficacy of mu- and kappa-opioid agonists on nociceptive spinal reflexes in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Electric Stimulation; Fentanyl; Male; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Spinal Cord | 1994 |
[Effect of agonists of opioid receptor on coronary arterial strips in porcine].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Coronary Vessels; Fentanyl; Haloperidol; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Receptors, Opioid; Swine | 1994 |
Evaluation of the interaction of mu and kappa opioid agonists on locomotor behavior in the horse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Fentanyl; Horses; Motor Activity; Pyrrolidines | 1993 |
Discriminative stimulus effects of the 5HT1A agonist 8-OH-DPAT: attenuation by mu but not by kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Benzomorphans; Discrimination Learning; Drug Therapy, Combination; Fentanyl; Male; Morphine; Narcotics; Pyrimidines; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin Receptor Agonists | 1995 |
Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Afferent Pathways; Animals; Benzyl Compounds; Colon; Fentanyl; Male; Morphine; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation | 1997 |
Tolerance and cross-tolerance to the rate-suppressing effects of opioids in butorphanol-treated rats: influence of maintenance dose and relative efficacy at the mu receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Male; Naloxone; Phenobarbital; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Sufentanil | 1998 |
Antagonistic effect of orphanin FQ on opioid analgesia in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analgesics, Opioid; Animals; Enkephalin, Leucine; Fentanyl; Injections, Intraventricular; Injections, Spinal; Male; Nociceptin; Opioid Peptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Local; Animals; Azocines; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzimidazoles; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Fentanyl; Heroin; Macaca mulatta; Male; Morphine; Nalbuphine; Pain Measurement; Receptors, Opioid; Respiration; Time Factors | 2000 |
Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Drug Tolerance; Fentanyl; Generalization, Stimulus; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Analysis of binding domain and function of chimeric mu/kappa opioid receptors to ohmefentanyl stereoisomers.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Cyclic AMP; Dynorphins; Fentanyl; Peptide Fragments; Protein Structure, Tertiary; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Stereoisomerism | 2001 |
Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Area Under Curve; Benzamides; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Fentanyl; Ketamine; Male; Mice; Morphine; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 2002 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Clonidine; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Ketamine; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, Opioid | 2002 |
Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Exons; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Mice, Knockout; Morphine Derivatives; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2003 |
Differential effects of opioid peptides on myocardial ischemic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Cardiotonic Agents; Enkephalin, Leucine-2-Alanine; Fentanyl; Heart; In Vitro Techniques; Microscopy, Electron; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Opioid Peptides; Oxygen Consumption; Rabbits; Recovery of Function | 2004 |
Attenuation of the gerbil writhing response by mu-, kappa- and delta-opioids, and NK-1, -2 and -3 receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdomen; Acetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Biphenyl Compounds; Butanols; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Fentanyl; Gerbillinae; Malates; Morphine; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pain Measurement; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazoles | 2004 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Capsaicin; Carrageenan; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enkephalin, D-Penicillamine (2,5)-; Extravasation of Diagnostic and Therapeutic Materials; Fentanyl; Hindlimb; Histamine Antagonists; Inflammation; Male; Morphine; Narcotic Antagonists; Oxidopamine; p-Methoxy-N-methylphenethylamine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Area Under Curve; Benzamides; Dose-Response Relationship, Drug; Female; Fentanyl; Hydrocortisone; Hypothalamo-Hypophyseal System; Macaca mulatta; Male; Piperazines; Pituitary-Adrenal System; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Nociceptin produces antinociception after spinal administration in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Spinal; Naltrexone; Nociceptin; Opioid Peptides; Pain Threshold; Peptide Fragments; Rana pipiens | 2009 |
Kappa and delta opioid receptor signaling is augmented in the failing heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium Signaling; Cardiomegaly; Cardiomyopathies; Cricetinae; Cyclic AMP; Fentanyl; Heart Failure; Heart Function Tests; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Myocardial Contraction; Opioid Peptides; Pertussis Toxin; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Signal Transduction; Systole | 2009 |
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fentanyl; Hyperalgesia; Imidazoles; Inflammation; Macaca; Male; Nociceptive Pain; Pain Measurement; Piperazines; Receptors, Opioid; Spiro Compounds | 2014 |
Analysis of Novel Synthetic Opioids U-47700, U-50488 and Furanyl Fentanyl by LC-MS/MS in Postmortem Casework.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Autopsy; Benzamides; Calibration; Chromatography, Liquid; Drug Overdose; Fentanyl; Furans; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Male; Morphine; Sheep; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |